5HT7R
802
Total Contact Pairs
82
Significant Changes
9.84
Max Increase
-8.37
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | HIS152 (3.22x22) | ASN226 | 9.838 | 0.000 | +9.838 | HIGH |
| 2 | ASP465 | LYS466 | 8.796 | 0.000 | +8.796 | HIGH |
| 3 | TYR190 (34.53x53) | GLN194 (34.57x57) | 1.318 | 9.687 | -8.369 | HIGH |
| 4 | LYS111 (12.49x49) | LEU410 | 0.000 | 7.925 | -7.925 | HIGH |
| 5 | HIS460 | ASN461 | 7.913 | 0.000 | +7.913 | HIGH |
| 6 | VAL225 | LEU232 (45.51x51) | 7.862 | 0.103 | +7.759 | HIGH |
| 7 | HIS273 (5.72x72) | ILE316 (6.24x24) | 0.000 | 6.957 | -6.957 | HIGH |
| 8 | TRP462 | LEU463 | 6.978 | 0.097 | +6.881 | HIGH |
| 9 | TYR263 (5.62x62) | ARG267 (5.66x66) | 0.690 | 7.485 | -6.795 | HIGH |
| 10 | GLU429 | ARG433 | 0.000 | 6.760 | -6.760 | HIGH |
| 11 | ARG389 (8.48x48) | GLU417 | 0.000 | 6.751 | -6.751 | HIGH |
| 12 | GLN73 | LYS147 (23.49x49) | 0.000 | 6.323 | -6.323 | HIGH |
| 13 | ASN224 | LEU232 (45.51x51) | 2.929 | 9.247 | -6.318 | HIGH |
| 14 | PHE275 (5.74x74) | ASN315 | 6.317 | 0.000 | +6.317 | HIGH |
| 15 | PHE275 (5.74x74) | HIS311 | 6.042 | 0.000 | +6.042 | HIGH |
| 16 | TRP462 | LYS466 | 0.000 | 5.985 | -5.985 | HIGH |
| 17 | PHE237 (5.36x37) | PRO351 (6.59x59) | 0.203 | 6.084 | -5.881 | HIGH |
| 18 | ASP179 (3.49x49) | ARG180 (3.50x50) | 0.000 | 5.801 | -5.801 | HIGH |
| 19 | TYR259 (5.58x58) | GLY330 (6.38x38) | 0.000 | 5.798 | -5.798 | HIGH |
| 20 | SER269 (5.68x68) | PHE319 (6.27x27) | 0.000 | 5.772 | -5.772 | HIGH |
| 21 | ASN405 | ARG408 | 0.000 | 5.715 | -5.715 | HIGH |
| 22 | TYR403 (8.62x62) | ASN407 | 5.517 | 0.000 | +5.517 | HIGH |
| 23 | TYR76 | LYS81 (1.32x32) | 0.000 | 5.393 | -5.393 | HIGH |
| 24 | ILE74 | TYR76 | 0.000 | 5.381 | -5.381 | HIGH |
| 25 | PHE336 (6.44x44) | ASN376 (7.45x45) | 0.979 | 6.354 | -5.375 | HIGH |
| 26 | SER43 | TRP44 | 0.000 | 5.367 | -5.367 | HIGH |
| 27 | TRP340 (6.48x48) | ASN376 (7.45x45) | 7.059 | 1.698 | +5.361 | HIGH |
| 28 | HIS416 | LYS420 | 0.000 | 5.145 | -5.145 | HIGH |
| 29 | SER116 (2.39x39) | ASP179 (3.49x49) | 0.178 | 5.310 | -5.132 | HIGH |
| 30 | LYS81 (1.32x32) | LEU143 (2.66x65) | 0.752 | 5.855 | -5.103 | HIGH |
| 31 | CYS70 | CYS358 | 0.000 | 5.082 | -5.082 | HIGH |
| 32 | ALA270 (5.69x69) | GLU322 (6.30x30) | 5.056 | 0.000 | +5.056 | HIGH |
| 33 | ILE170 (3.40x40) | PHE336 (6.44x44) | 1.194 | 6.206 | -5.012 | HIGH |
| 34 | ILE74 | GLY145 (2.68x67) | 0.000 | 4.990 | -4.990 | MED |
| 35 | CYS354 | CYS360 | 3.863 | 8.526 | -4.663 | MED |
| 36 | ASP390 (8.49x49) | LEU410 | 0.000 | 4.562 | -4.562 | MED |
| 37 | ARG350 (6.58x58) | SER359 | 0.000 | 4.295 | -4.295 | MED |
| 38 | SER397 (8.56x56) | GLN402 (8.61x61) | 0.000 | 4.220 | -4.220 | MED |
| 39 | TRP340 (6.48x48) | GLY373 (7.42x41) | 5.222 | 9.436 | -4.214 | MED |
| 40 | THR328 (6.36x36) | PHE387 (7.56x56) | 7.450 | 3.329 | +4.120 | MED |
| 41 | ALA266 (5.65x65) | PHE319 (6.27x27) | 0.000 | 4.104 | -4.104 | MED |
| 42 | PRO33 | ASP34 | 0.000 | 3.987 | -3.987 | MED |
| 43 | PHE336 (6.44x44) | TRP340 (6.48x48) | 2.633 | 6.569 | -3.936 | MED |
| 44 | HIS311 | ASN315 | 0.000 | 3.870 | -3.870 | MED |
| 45 | MET255 (5.54x54) | PHE336 (6.44x44) | 4.269 | 0.420 | +3.849 | MED |
| 46 | LYS110 (12.48x48) | ASN407 | 0.000 | 3.771 | -3.771 | MED |
| 47 | LEU173 (3.43x43) | TYR384 (7.53x53) | 3.707 | 0.000 | +3.707 | MED |
| 48 | ARG180 (3.50x50) | TYR384 (7.53x53) | 3.673 | 0.000 | +3.673 | MED |
| 49 | TYR76 | ILE84 (1.35x35) | 0.000 | 3.653 | -3.653 | MED |
| 50 | ALA133 (2.56x551) | MET161 (3.31x31) | 4.529 | 0.988 | +3.541 | MED |
| 51 | ILE170 (3.40x40) | TRP340 (6.48x48) | 3.522 | 0.000 | +3.522 | MED |
| 52 | MET476 | ILE477 | 3.418 | 0.000 | +3.418 | MED |
| 53 | ARG427 | GLU429 | 0.000 | 3.408 | -3.408 | MED |
| 54 | MET255 (5.54x54) | VAL333 (6.41x41) | 0.000 | 3.402 | -3.402 | MED |
| 55 | CYS302 | CYS435 | 0.000 | 3.326 | -3.326 | MED |
| 56 | PRO342 (6.50x50) | PHE369 (7.38x37) | 8.571 | 5.246 | +3.325 | MED |
| 57 | GLY98 (1.49x49) | PRO381 (7.50x50) | 0.970 | 4.179 | -3.209 | MED |
| 58 | GLN235 | PRO351 (6.59x59) | 0.756 | 3.943 | -3.188 | MED |
| 59 | ASP30 | LEU31 | 0.000 | 3.179 | -3.179 | MED |
| 60 | ALA385 (7.54x54) | ARG392 (8.51x51) | 1.615 | 4.784 | -3.170 | MED |
| 61 | ILE213 (4.56x56) | TYR239 (5.38x39) | 3.136 | 0.000 | +3.136 | MED |
| 62 | ILE331 (6.39x39) | PHE387 (7.56x56) | 1.063 | 4.140 | -3.077 | MED |
| 63 | ASN376 (7.45x45) | ASN380 (7.49x49) | 4.270 | 1.194 | +3.076 | MED |
| 64 | GLU298 | ARG438 | 0.000 | 3.068 | -3.068 | MED |
| 65 | VAL286 | LYS297 | 3.044 | 0.000 | +3.044 | MED |
| 66 | LEU28 | PRO29 | 0.328 | 3.323 | -2.995 | MED |
| 67 | SER105 | THR394 | 0.000 | 2.943 | -2.943 | MED |
| 68 | PRO457 | ASP458 | 3.292 | 0.382 | +2.910 | MED |
| 69 | MET252 | THR337 | 2.099 | 4.948 | -2.849 | MED |
| 70 | ASP38 | PRO39 | 0.685 | 3.488 | -2.803 | MED |
| 71 | HIS152 (3.22x22) | VAL225 | 0.000 | 2.801 | -2.801 | MED |
| 72 | HIS273 (5.72x72) | ILE318 | 2.771 | 0.000 | +2.771 | MED |
| 73 | ILE159 | ILE233 | 3.052 | 0.359 | +2.693 | MED |
| 74 | ARG180 (3.50x50) | LEU329 | 0.000 | 2.687 | -2.687 | MED |
| 75 | ALA270 (5.69x69) | ILE318 | 2.656 | 0.000 | +2.656 | MED |
| 76 | TRP148 | PHE158 | 3.468 | 6.094 | -2.626 | MED |
| 77 | SER116 (2.39x39) | ARG180 (3.50x50) | 0.000 | 2.610 | -2.610 | MED |
| 78 | ILE74 | LEU363 | 0.000 | 2.587 | -2.587 | MED |
| 79 | PHE386 | ARG392 (8.51x51) | 4.219 | 1.639 | +2.580 | MED |
| 80 | PRO217 | ALA222 | 4.480 | 1.962 | +2.519 | MED |
| 81 | PRO216 | TYR239 (5.38x39) | 2.474 | 0.000 | +2.474 | MED |
| 82 | LEU398 | TYR403 (8.62x62) | 0.000 | 2.465 | -2.465 | MED |
| 83 | MET255 (5.54x54) | TYR259 (5.58x58) | 2.427 | 0.000 | +2.427 | LOW |
| 84 | ASP179 (3.49x49) | TYR190 (34.53x53) | 5.826 | 8.242 | -2.416 | LOW |
| 85 | LYS111 (12.49x49) | ASP390 (8.49x49) | 0.000 | 2.408 | -2.408 | LOW |
| 86 | LEU182 | TYR190 (34.53x53) | 11.272 | 8.886 | +2.387 | LOW |
| 87 | VAL109 | ASN407 | 0.000 | 2.375 | -2.375 | LOW |
| 88 | ASN224 | CYS231 | 0.000 | 2.224 | -2.224 | LOW |
| 89 | ILE159 | LEU232 (45.51x51) | 2.468 | 0.281 | +2.187 | LOW |
| 90 | HIS152 (3.22x22) | ASN156 | 0.425 | 2.610 | -2.185 | LOW |
| 91 | VAL286 | ILE287 | 0.000 | 2.156 | -2.156 | LOW |
| 92 | SER177 | MET255 (5.54x54) | 2.865 | 0.713 | +2.152 | LOW |
| 93 | ASP142 | ARG367 | 6.793 | 4.688 | +2.104 | LOW |
| 94 | CYS155 | ASN224 | 0.000 | 2.101 | -2.101 | LOW |
| 95 | GLN400 | GLN402 (8.61x61) | 0.000 | 2.096 | -2.096 | LOW |
| 96 | TYR181 | GLN261 | 1.714 | 3.806 | -2.092 | LOW |
| 97 | ASN156 | ASN226 | 2.089 | 0.000 | +2.089 | LOW |
| 98 | GLN402 (8.61x61) | LYS409 | 0.000 | 2.073 | -2.073 | LOW |
| 99 | ASP127 | ASN380 (7.49x49) | 5.307 | 3.249 | +2.058 | LOW |
| 100 | ARG350 (6.58x58) | CYS358 | 2.054 | 0.000 | +2.054 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.44 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 81-98 | - | 0 | 81 (-5.4), 84 (-3.7), 98 (-3.2) | 3 |
| TM2 | 116-145 | 133 (3.5) | 1 | 116 (-5.1), 143 (-5.1), 145 (-5.0) | 3 |
| TM3 | 152-180 | 152 (9.8), 173 (3.7), 161 (3.5) | 3 | 179 (-5.8), 180 (-5.8), 170 (-5.0) | 3 |
| TM4 | 213-213 | 213 (3.1) | 1 | - | 0 |
| TM5 | 237-275 | 275 (6.3), 270 (5.1), 255 (3.8), 239 (3.1) | 4 | 273 (-7.0), 263 (-6.8), 267 (-6.8), 237 (-5.9), 259 (-5.8), 269 (-5.8), 266 (-4.1) | 7 |
| TM6 | 316-351 | 340 (5.4), 322 (5.1), 328 (4.1), 342 (3.3) | 4 | 316 (-7.0), 351 (-5.9), 330 (-5.8), 319 (-5.8), 336 (-5.4), 350 (-4.3), 333 (-3.4), 331 (-3.1) | 8 |
| TM7 | 369-387 | 387 (4.1), 384 (3.7), 369 (3.3), 380 (3.1) | 4 | 376 (-5.4), 373 (-4.2), 381 (-3.2), 385 (-3.2) | 4 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 110-111 | - | 0 | 111 (-7.9), 110 (-3.8) | 2 |
| ICL2 | 190-194 | - | 0 | 190 (-8.4), 194 (-8.4) | 2 |
| ICL3 | 286-315 | 315 (6.3), 311 (6.0), 286 (3.0), 297 (3.0) | 4 | 302 (-3.3), 298 (-3.1) | 2 |
| ECL1 | 147-147 | - | 0 | 147 (-6.3) | 1 |
| ECL2 | 224-235 | 226 (9.8), 225 (7.8), 232 (7.8) | 3 | 224 (-6.3), 235 (-3.2) | 2 |
| ECL3 | 354-360 | - | 0 | 358 (-5.1), 354 (-4.7), 360 (-4.7), 359 (-4.3) | 4 |
| H8 | 389-403 | 403 (5.5) | 1 | 389 (-6.8), 390 (-4.6), 397 (-4.2), 402 (-4.2), 392 (-3.2) | 5 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
100 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 152 | p.His152Tyr | c.454C>T | 2.63e-05 | 4 / 0 | 9.84 | 0.149 | BENIGN | 0.49 | rs138419441 |
| 466 | p.Lys466Gln | c.1396A>C | 2.79e-06 | 4 / 0 | 8.80 | 0.107 | BENIGN | 0.39 | rs368319541 |
| 465 | p.Asp465Glu | c.1395C>A | 1.40e-06 | 2 / 0 | 8.80 | 0.097 | BENIGN | 0.81 | rs1375212896 |
| 465 | p.Asp465Gly | c.1394A>G | 1.40e-06 | 2 / 0 | 8.80 | - | nan | - | rs1235702835 |
| 465 | p.Asp465His | c.1393G>C | 1.37e-06 | 2 / 0 | 8.80 | - | nan | - | |
| 190 | p.Tyr190His | c.568T>C | 8.22e-06 | 12 / 0 | 8.37 | 0.996 | PATHOGENIC | 0.98 | rs560218001 |
| 190 | p.Tyr190Asn | c.568T>A | 6.85e-07 | 1 / 0 | 8.37 | - | nan | - | |
| 410 | p.Leu410Phe | c.1228C>T | 4.79e-06 | 7 / 0 | 7.92 | 0.947 | PATHOGENIC | 0.83 | rs754595089 |
| 461 | p.Asn461Ile | c.1382A>T | 1.37e-06 | 2 / 0 | 7.91 | 0.110 | BENIGN | 0.57 | rs1447695961 |
| 460 | p.His460Gln | c.1380C>G | 3.42e-06 | 5 / 0 | 7.91 | 0.079 | BENIGN | 0.42 | rs748805138 |
| 461 | p.Asn461Ser | c.1382A>G | 1.23e-05 | 18 / 0 | 7.91 | - | nan | - | rs1447695961 |
| 316 | p.Ile316Phe | c.946A>T | 6.84e-07 | 1 / 0 | 6.96 | 0.355 | AMBIGUOUS | 0.51 | |
| 462 | p.Trp462Leu | c.1385G>T | 6.16e-06 | 9 / 0 | 6.88 | 0.103 | BENIGN | 0.44 | rs1392171844 |
| 267 | p.Arg267Trp | c.799A>T | 6.84e-07 | 1 / 0 | 6.80 | 0.524 | AMBIGUOUS | 0.74 | |
| 433 | p.Arg433Ser | c.1299G>T | 6.86e-07 | 1 / 0 | 6.76 | 0.270 | BENIGN | 0.44 | |
| 429 | p.Glu429Ala | c.1286A>C | 2.05e-06 | 3 / 0 | 6.76 | 0.121 | BENIGN | 0.67 | |
| 433 | p.Arg433Lys | c.1298G>A | 6.86e-07 | 1 / 0 | 6.76 | - | nan | - | rs748459275 |
| 389 | p.Arg389Gln | c.1166G>A | 1.92e-05 | 28 / 0 | 6.75 | 0.640 | PATHOGENIC | 0.67 | rs765069519 |
| 389 | p.Arg389Gly | c.1165C>G | 6.57e-06 | 1 / 0 | 6.75 | - | nan | - | rs750208564 |
| 389 | p.Arg389Trp | c.1165C>T | 8.89e-06 | 13 / 0 | 6.75 | - | nan | - | rs750208564 |
| 73 | p.Gln73His | c.219G>C | 2.05e-06 | 3 / 0 | 6.32 | 0.126 | BENIGN | 0.59 | rs1179884815 |
| 147 | p.Lys147Arg | c.440A>G | 1.37e-06 | 2 / 0 | 6.32 | 0.074 | BENIGN | 0.38 | |
| 73 | p.Gln73Arg | c.218A>G | 2.05e-06 | 3 / 0 | 6.32 | - | nan | - | rs772321011 |
| 224 | p.Asn224Lys | c.672T>G | 6.84e-07 | 1 / 0 | 6.32 | 0.998 | PATHOGENIC | 0.57 | rs753979574 |
| 315 | p.Asn315Ser | c.944A>G | 1.37e-06 | 2 / 0 | 6.32 | 0.268 | BENIGN | 0.55 | rs1334803873 |
| 311 | p.His311Arg | c.932A>G | 6.84e-07 | 1 / 0 | 6.04 | 0.136 | BENIGN | 0.50 | rs1844690722 |
| 180 | p.Arg180Met | c.539G>T | 7.01e-07 | 1 / 0 | 5.80 | 1.000 | PATHOGENIC | 0.96 | |
| 179 | p.Asp179Ala | c.536A>C | 1.39e-06 | 2 / 0 | 5.80 | 0.999 | PATHOGENIC | 0.90 | rs773257840 |
| 330 | p.Gly330Glu | c.989G>A | 1.37e-06 | 2 / 0 | 5.80 | 1.000 | PATHOGENIC | 0.92 | |
| 408 | p.Arg408Leu | c.1223G>T | 6.84e-07 | 1 / 0 | 5.71 | 0.919 | PATHOGENIC | 0.89 | |
| 405 | p.Asn405Thr | c.1214A>C | 2.63e-05 | 4 / 0 | 5.71 | 0.524 | AMBIGUOUS | 0.72 | rs780871493 |
| 408 | p.Arg408Gln | c.1223G>A | 2.05e-06 | 3 / 0 | 5.71 | - | nan | - | rs1202153755 |
| 408 | p.Arg408Trp | c.1222C>T | 6.84e-07 | 1 / 0 | 5.71 | - | nan | - | rs1844682656 |
| 405 | p.Asn405His | c.1213A>C | 6.84e-07 | 1 / 0 | 5.71 | - | nan | - | |
| 405 | p.Asn405Asp | c.1213A>G | 6.84e-07 | 1 / 0 | 5.71 | - | nan | - | |
| 403 | p.Tyr403His | c.1207T>C | 1.37e-06 | 2 / 0 | 5.52 | 0.851 | PATHOGENIC | 0.68 | |
| 407 | p.Asn407Ser | c.1220A>G | 6.84e-07 | 1 / 0 | 5.52 | 0.485 | AMBIGUOUS | 0.76 | rs1201444262 |
| 407 | p.Asn407Asp | c.1219A>G | 6.84e-07 | 1 / 0 | 5.52 | - | nan | - | |
| 76 | p.Tyr76Asn | c.226T>A | 6.84e-07 | 1 / 0 | 5.39 | 0.500 | AMBIGUOUS | 0.59 | rs1327681567 |
| 74 | p.Ile74Val | c.220A>G | 6.84e-07 | 1 / 0 | 5.38 | 0.168 | BENIGN | 0.60 | |
| 376 | p.Asn376Lys | c.1128C>G | 6.84e-07 | 1 / 0 | 5.37 | 1.000 | PATHOGENIC | 1.00 | |
| 376 | p.Asn376Asp | c.1126A>G | 6.84e-07 | 1 / 0 | 5.37 | - | nan | - | |
| 44 | p.Trp44Arg | c.130T>C | 1.38e-06 | 2 / 0 | 5.37 | 0.120 | BENIGN | 0.42 | rs1206667530 |
| 43 | p.Ser43Phe | c.128C>T | 6.90e-07 | 1 / 0 | 5.37 | 0.104 | BENIGN | 0.74 | |
| 43 | p.Ser43Pro | c.127T>C | 6.90e-07 | 1 / 0 | 5.37 | - | nan | - | rs1846606855 |
| 416 | p.His416Gln | c.1248T>A | 2.05e-06 | 3 / 0 | 5.15 | 0.752 | PATHOGENIC | 0.88 | rs61732493 |
| 416 | p.His416Arg | c.1247A>G | 2.67e-05 | 39 / 0 | 5.15 | - | nan | - | rs750310268 |
| 358 | p.Cys358Phe | c.1073G>T | 2.05e-06 | 3 / 0 | 5.08 | 0.967 | PATHOGENIC | 0.67 | rs376342721 |
| 70 | p.Cys70Tyr | c.209G>A | 1.37e-06 | 2 / 0 | 5.08 | 0.962 | PATHOGENIC | 0.69 | rs775916918 |
| 358 | p.Cys358Tyr | c.1073G>A | 6.57e-06 | 1 / 0 | 5.08 | - | nan | - | rs376342721 |
| 70 | p.Cys70Ser | c.209G>C | 1.37e-06 | 2 / 0 | 5.08 | - | nan | - | rs775916918 |
| 70 | p.Cys70Gly | c.208T>G | 6.84e-07 | 1 / 0 | 5.08 | - | nan | - | |
| 322 | p.Glu322Asp | c.966A>C | 6.84e-07 | 1 / 0 | 5.06 | 0.996 | PATHOGENIC | 0.97 | |
| 270 | p.Ala270Val | c.809C>T | 6.84e-07 | 1 / 0 | 5.06 | 0.381 | AMBIGUOUS | 0.46 | rs1187187340 |
| 270 | p.Ala270Thr | c.808G>A | 6.84e-07 | 1 / 0 | 5.06 | - | nan | - | rs1263867717 |
| 170 | p.Ile170Met | c.510C>G | 6.86e-07 | 1 / 0 | 5.01 | 0.974 | PATHOGENIC | 0.94 | |
| 145 | p.Gly145Arg | c.433G>C | 6.84e-07 | 1 / 0 | 4.99 | 0.932 | PATHOGENIC | 0.59 | rs1477741577 |
| 390 | p.Asp390Ala | c.1169A>C | 6.84e-07 | 1 / 0 | 4.56 | 0.996 | PATHOGENIC | 0.83 | |
| 390 | p.Asp390Asn | c.1168G>A | 6.84e-07 | 1 / 0 | 4.56 | - | nan | - | |
| 359 | p.Ser359Arg | c.1075A>C | 1.37e-06 | 2 / 0 | 4.29 | 0.935 | PATHOGENIC | 0.60 | rs1383417083 |
| 397 | p.Ser397Cys | c.1189A>T | 6.84e-07 | 1 / 0 | 4.22 | 0.122 | BENIGN | 0.48 | |
| 373 | p.Gly373Ala | c.1118G>C | 6.84e-07 | 1 / 0 | 4.21 | 0.986 | PATHOGENIC | 1.00 | |
| 387 | p.Phe387Ile | c.1159T>A | 6.84e-07 | 1 / 0 | 4.12 | 0.992 | PATHOGENIC | 0.75 | |
| 266 | p.Ala266Val | c.797C>T | 1.37e-06 | 2 / 0 | 4.10 | 0.906 | PATHOGENIC | 0.92 | rs1844696024 |
| 266 | p.Ala266Ser | c.796G>T | 6.84e-07 | 1 / 0 | 4.10 | - | nan | - | rs1844696110 |
| 33 | p.Pro33His | c.98C>A | 6.93e-07 | 1 / 0 | 3.99 | 0.082 | BENIGN | 0.43 | |
| 34 | p.Asp34Glu | c.102C>A | 1.39e-06 | 2 / 0 | 3.99 | 0.063 | BENIGN | 0.32 | |
| 34 | p.Asp34Asn | c.100G>A | 1.39e-06 | 2 / 0 | 3.99 | - | nan | - | rs758993362 |
| 34 | p.Asp34Tyr | c.100G>T | 6.93e-07 | 1 / 0 | 3.99 | - | nan | - | |
| 33 | p.Pro33Arg | c.98C>G | 6.93e-07 | 1 / 0 | 3.99 | - | nan | - | |
| 110 | p.Lys110Gln | c.328A>C | 6.84e-07 | 1 / 0 | 3.77 | 0.811 | PATHOGENIC | 0.75 | |
| 173 | p.Leu173Pro | c.518T>C | 6.88e-07 | 1 / 0 | 3.71 | 1.000 | PATHOGENIC | 0.91 | |
| 384 | p.Tyr384Cys | c.1151A>G | 6.84e-07 | 1 / 0 | 3.71 | 0.980 | PATHOGENIC | 0.99 | |
| 84 | p.Ile84Ser | c.251T>G | 4.10e-06 | 6 / 0 | 3.65 | 0.781 | PATHOGENIC | 0.69 | |
| 161 | p.Met161Val | c.481A>G | 4.79e-06 | 7 / 0 | 3.54 | 0.412 | AMBIGUOUS | 0.54 | rs1447057998 |
| 161 | p.Met161Leu | c.481A>C | 6.84e-07 | 1 / 0 | 3.54 | - | nan | - | |
| 476 | p.Met476Ile | c.1428G>A | 6.90e-07 | 1 / 0 | 3.42 | 0.194 | BENIGN | 0.58 | rs867096969 |
| 476 | p.Met476Val | c.1426A>G | 1.38e-06 | 2 / 0 | 3.42 | - | nan | - | rs1844567810 |
| 427 | p.Arg427Ser | c.1281A>T | 6.85e-07 | 1 / 0 | 3.41 | 0.247 | BENIGN | 0.64 | |
| 427 | p.Arg427Lys | c.1280G>A | 1.37e-06 | 2 / 0 | 3.41 | - | nan | - | rs764438254 |
| 333 | p.Val333Ile | c.997G>A | 1.78e-05 | 26 / 0 | 3.40 | 0.281 | BENIGN | 0.73 | rs780476203 |
| 302 | p.Cys302Tyr | c.905G>A | 7.53e-06 | 11 / 0 | 3.33 | 0.319 | BENIGN | 0.47 | rs1844692003 |
| 435 | p.Cys435Phe | c.1304G>T | 6.85e-07 | 1 / 0 | 3.33 | 0.096 | BENIGN | 0.36 | |
| 435 | p.Cys435Tyr | c.1304G>A | 6.85e-07 | 1 / 0 | 3.33 | - | nan | - | |
| 302 | p.Cys302Gly | c.904T>G | 6.84e-07 | 1 / 0 | 3.33 | - | nan | - | |
| 369 | p.Phe369Cys | c.1106T>G | 2.74e-06 | 4 / 0 | 3.33 | 0.215 | BENIGN | 0.56 | rs752277945 |
| 381 | p.Pro381Arg | c.1142C>G | 6.84e-07 | 1 / 0 | 3.21 | 0.999 | PATHOGENIC | 1.00 | |
| 98 | p.Gly98Arg | c.292G>C | 6.84e-07 | 1 / 0 | 3.21 | 0.999 | PATHOGENIC | 0.85 | |
| 381 | p.Pro381Ser | c.1141C>T | 6.84e-07 | 1 / 0 | 3.21 | - | nan | - | |
| 30 | p.Asp30Val | c.89A>T | 6.93e-07 | 1 / 0 | 3.18 | 0.090 | BENIGN | 0.39 | |
| 31 | p.Leu31Phe | c.93G>T | 6.93e-07 | 1 / 0 | 3.18 | 0.062 | BENIGN | 0.34 | |
| 31 | p.Leu31Phe | c.93G>C | 1.39e-06 | 2 / 0 | 3.18 | - | nan | - | |
| 30 | p.Asp30Asn | c.88G>A | 2.08e-06 | 3 / 0 | 3.18 | - | nan | - | rs1422652732 |
| 392 | p.Arg392Thr | c.1175G>C | 6.84e-07 | 1 / 0 | 3.17 | 0.996 | PATHOGENIC | 0.78 | rs777064737 |
| 385 | p.Ala385Val | c.1154C>T | 6.84e-07 | 1 / 0 | 3.17 | 0.914 | PATHOGENIC | 0.69 | |
| 239 | p.Tyr239Cys | c.716A>G | 6.84e-07 | 1 / 0 | 3.14 | 0.999 | PATHOGENIC | 0.97 | |
| 213 | p.Ile213Val | c.637A>G | 2.80e-05 | 41 / 0 | 3.14 | 0.153 | BENIGN | 0.94 | rs980457289 |
| 438 | p.Cys438Gly | c.1312T>G | 6.58e-06 | 1 / 0 | 3.07 | 0.113 | BENIGN | 0.33 | rs747968672 |
| 438 | p.Arg438Trp | c.1312A>T | 6.57e-06 | 1 / 0 | 3.07 | - | nan | - | rs1212700546 |
| 286 | p.Val286Ile | c.856G>A | 1.03e-04 | 150 / 0 | 3.04 | 0.073 | BENIGN | 0.39 | rs546114010 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.44, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 152 | HIS | 226 | ASN | 9.838 | 0.000 | 9.838 | 9.838 |
| 465 | ASP | 466 | LYS | 8.796 | 0.000 | 8.796 | 8.796 |
| 190 | TYR | 194 | GLN | 1.318 | 9.687 | -8.369 | 8.369 |
| 111 | LYS | 410 | LEU | 0.000 | 7.925 | -7.925 | 7.925 |
| 460 | HIS | 461 | ASN | 7.913 | 0.000 | 7.913 | 7.913 |
| 225 | VAL | 232 | LEU | 7.862 | 0.103 | 7.759 | 7.759 |
| 273 | HIS | 316 | ILE | 0.000 | 6.957 | -6.957 | 6.957 |
| 462 | TRP | 463 | LEU | 6.978 | 0.097 | 6.881 | 6.881 |
| 263 | TYR | 267 | ARG | 0.690 | 7.485 | -6.795 | 6.795 |
| 429 | GLU | 433 | ARG | 0.000 | 6.760 | -6.760 | 6.760 |
| 389 | ARG | 417 | GLU | 0.000 | 6.751 | -6.751 | 6.751 |
| 73 | GLN | 147 | LYS | 0.000 | 6.323 | -6.323 | 6.323 |
| 224 | ASN | 232 | LEU | 2.929 | 9.247 | -6.318 | 6.318 |
| 275 | PHE | 315 | ASN | 6.317 | 0.000 | 6.317 | 6.317 |
| 275 | PHE | 311 | HIS | 6.042 | 0.000 | 6.042 | 6.042 |
| 462 | TRP | 466 | LYS | 0.000 | 5.985 | -5.985 | 5.985 |
| 237 | PHE | 351 | PRO | 0.203 | 6.084 | -5.881 | 5.881 |
| 179 | ASP | 180 | ARG | 0.000 | 5.801 | -5.801 | 5.801 |
| 259 | TYR | 330 | GLY | 0.000 | 5.798 | -5.798 | 5.798 |
| 269 | SER | 319 | PHE | 0.000 | 5.772 | -5.772 | 5.772 |
| 405 | ASN | 408 | ARG | 0.000 | 5.715 | -5.715 | 5.715 |
| 403 | TYR | 407 | ASN | 5.517 | 0.000 | 5.517 | 5.517 |
| 76 | TYR | 81 | LYS | 0.000 | 5.393 | -5.393 | 5.393 |
| 74 | ILE | 76 | TYR | 0.000 | 5.381 | -5.381 | 5.381 |
| 336 | PHE | 376 | ASN | 0.979 | 6.354 | -5.375 | 5.375 |
| 43 | SER | 44 | TRP | 0.000 | 5.367 | -5.367 | 5.367 |
| 340 | TRP | 376 | ASN | 7.059 | 1.698 | 5.361 | 5.361 |
| 416 | HIS | 420 | LYS | 0.000 | 5.145 | -5.145 | 5.145 |
| 116 | SER | 179 | ASP | 0.178 | 5.310 | -5.132 | 5.132 |
| 81 | LYS | 143 | LEU | 0.752 | 5.855 | -5.103 | 5.103 |
| 70 | CYS | 358 | CYS | 0.000 | 5.082 | -5.082 | 5.082 |
| 270 | ALA | 322 | GLU | 5.056 | 0.000 | 5.056 | 5.056 |
| 170 | ILE | 336 | PHE | 1.194 | 6.206 | -5.012 | 5.012 |
| 74 | ILE | 145 | GLY | 0.000 | 4.990 | -4.990 | 4.990 |
| 354 | CYS | 360 | CYS | 3.863 | 8.526 | -4.663 | 4.663 |
| 390 | ASP | 410 | LEU | 0.000 | 4.562 | -4.562 | 4.562 |
| 350 | ARG | 359 | SER | 0.000 | 4.295 | -4.295 | 4.295 |
| 397 | SER | 402 | GLN | 0.000 | 4.220 | -4.220 | 4.220 |
| 340 | TRP | 373 | GLY | 5.222 | 9.436 | -4.214 | 4.214 |
| 328 | THR | 387 | PHE | 7.450 | 3.329 | 4.120 | 4.120 |
| 266 | ALA | 319 | PHE | 0.000 | 4.104 | -4.104 | 4.104 |
| 33 | PRO | 34 | ASP | 0.000 | 3.987 | -3.987 | 3.987 |
| 336 | PHE | 340 | TRP | 2.633 | 6.569 | -3.936 | 3.936 |
| 311 | HIS | 315 | ASN | 0.000 | 3.870 | -3.870 | 3.870 |
| 255 | MET | 336 | PHE | 4.269 | 0.420 | 3.849 | 3.849 |
| 110 | LYS | 407 | ASN | 0.000 | 3.771 | -3.771 | 3.771 |
| 173 | LEU | 384 | TYR | 3.707 | 0.000 | 3.707 | 3.707 |
| 180 | ARG | 384 | TYR | 3.673 | 0.000 | 3.673 | 3.673 |
| 76 | TYR | 84 | ILE | 0.000 | 3.653 | -3.653 | 3.653 |
| 133 | ALA | 161 | MET | 4.529 | 0.988 | 3.541 | 3.541 |
| 170 | ILE | 340 | TRP | 3.522 | 0.000 | 3.522 | 3.522 |
| 476 | MET | 477 | ILE | 3.418 | 0.000 | 3.418 | 3.418 |
| 427 | ARG | 429 | GLU | 0.000 | 3.408 | -3.408 | 3.408 |
| 255 | MET | 333 | VAL | 0.000 | 3.402 | -3.402 | 3.402 |
| 302 | CYS | 435 | CYS | 0.000 | 3.326 | -3.326 | 3.326 |
| 342 | PRO | 369 | PHE | 8.571 | 5.246 | 3.325 | 3.325 |
| 98 | GLY | 381 | PRO | 0.970 | 4.179 | -3.209 | 3.209 |
| 235 | GLN | 351 | PRO | 0.756 | 3.943 | -3.188 | 3.188 |
| 30 | ASP | 31 | LEU | 0.000 | 3.179 | -3.179 | 3.179 |
| 385 | ALA | 392 | ARG | 1.615 | 4.784 | -3.170 | 3.170 |
| 213 | ILE | 239 | TYR | 3.136 | 0.000 | 3.136 | 3.136 |
| 331 | ILE | 387 | PHE | 1.063 | 4.140 | -3.077 | 3.077 |
| 376 | ASN | 380 | ASN | 4.270 | 1.194 | 3.076 | 3.076 |
| 298 | GLU | 438 | ARG | 0.000 | 3.068 | -3.068 | 3.068 |
| 286 | VAL | 297 | LYS | 3.044 | 0.000 | 3.044 | 3.044 |
| 28 | LEU | 29 | PRO | 0.328 | 3.323 | -2.995 | 2.995 |
| 105 | SER | 394 | THR | 0.000 | 2.943 | -2.943 | 2.943 |
| 457 | PRO | 458 | ASP | 3.292 | 0.382 | 2.910 | 2.910 |
| 252 | MET | 337 | THR | 2.099 | 4.948 | -2.849 | 2.849 |
| 38 | ASP | 39 | PRO | 0.685 | 3.488 | -2.803 | 2.803 |
| 152 | HIS | 225 | VAL | 0.000 | 2.801 | -2.801 | 2.801 |
| 273 | HIS | 318 | ILE | 2.771 | 0.000 | 2.771 | 2.771 |
| 159 | ILE | 233 | ILE | 3.052 | 0.359 | 2.693 | 2.693 |
| 180 | ARG | 329 | LEU | 0.000 | 2.687 | -2.687 | 2.687 |
| 270 | ALA | 318 | ILE | 2.656 | 0.000 | 2.656 | 2.656 |
| 148 | TRP | 158 | PHE | 3.468 | 6.094 | -2.626 | 2.626 |
| 116 | SER | 180 | ARG | 0.000 | 2.610 | -2.610 | 2.610 |
| 74 | ILE | 363 | LEU | 0.000 | 2.587 | -2.587 | 2.587 |
| 386 | PHE | 392 | ARG | 4.219 | 1.639 | 2.580 | 2.580 |
| 217 | PRO | 222 | ALA | 4.480 | 1.962 | 2.519 | 2.519 |
| 216 | PRO | 239 | TYR | 2.474 | 0.000 | 2.474 | 2.474 |
| 398 | LEU | 403 | TYR | 0.000 | 2.465 | -2.465 | 2.465 |
| 255 | MET | 259 | TYR | 2.427 | 0.000 | 2.427 | 2.427 |
| 179 | ASP | 190 | TYR | 5.826 | 8.242 | -2.416 | 2.416 |
| 111 | LYS | 390 | ASP | 0.000 | 2.408 | -2.408 | 2.408 |
| 182 | LEU | 190 | TYR | 11.272 | 8.886 | 2.387 | 2.387 |
| 109 | VAL | 407 | ASN | 0.000 | 2.375 | -2.375 | 2.375 |
| 224 | ASN | 231 | CYS | 0.000 | 2.224 | -2.224 | 2.224 |
| 159 | ILE | 232 | LEU | 2.468 | 0.281 | 2.187 | 2.187 |
| 152 | HIS | 156 | ASN | 0.425 | 2.610 | -2.185 | 2.185 |
| 286 | VAL | 287 | ILE | 0.000 | 2.156 | -2.156 | 2.156 |
| 177 | SER | 255 | MET | 2.865 | 0.713 | 2.152 | 2.152 |
| 142 | ASP | 367 | ARG | 6.793 | 4.688 | 2.104 | 2.104 |
| 155 | CYS | 224 | ASN | 0.000 | 2.101 | -2.101 | 2.101 |
| 400 | GLN | 402 | GLN | 0.000 | 2.096 | -2.096 | 2.096 |
| 181 | TYR | 261 | GLN | 1.714 | 3.806 | -2.092 | 2.092 |
| 156 | ASN | 226 | ASN | 2.089 | 0.000 | 2.089 | 2.089 |
| 402 | GLN | 409 | LYS | 0.000 | 2.073 | -2.073 | 2.073 |
| 127 | ASP | 380 | ASN | 5.307 | 3.249 | 2.058 | 2.058 |
| 350 | ARG | 358 | CYS | 2.054 | 0.000 | 2.054 | 2.054 |
| 350 | ARG | 366 | GLU | 3.116 | 5.153 | -2.036 | 2.036 |
| 259 | TYR | 332 | ILE | 2.009 | 0.000 | 2.009 | 2.009 |
| 181 | TYR | 258 | MET | 4.191 | 2.203 | 1.988 | 1.988 |
| 235 | GLN | 350 | ARG | 10.291 | 8.306 | 1.986 | 1.986 |
| 450 | SER | 452 | TRP | 2.299 | 0.326 | 1.972 | 1.972 |
| 179 | ASP | 194 | GLN | 4.414 | 2.446 | 1.969 | 1.969 |
| 237 | PHE | 352 | PHE | 2.701 | 4.669 | -1.967 | 1.967 |
| 177 | SER | 259 | TYR | 1.964 | 0.000 | 1.964 | 1.964 |
| 397 | SER | 406 | ILE | 0.000 | 1.962 | -1.962 | 1.962 |
| 224 | ASN | 234 | SER | 4.467 | 2.508 | 1.959 | 1.959 |
| 170 | ILE | 252 | MET | 0.000 | 1.949 | -1.949 | 1.949 |
| 259 | TYR | 329 | LEU | 2.211 | 0.274 | 1.937 | 1.937 |
| 248 | PHE | 344 | PHE | 14.438 | 16.349 | -1.911 | 1.911 |
| 146 | GLY | 230 | VAL | 0.000 | 1.904 | -1.904 | 1.904 |
| 252 | MET | 336 | PHE | 3.022 | 1.119 | 1.903 | 1.903 |
| 384 | TYR | 391 | LEU | 0.505 | 2.407 | -1.902 | 1.902 |
| 99 | ASN | 124 | ALA | 5.721 | 3.820 | 1.901 | 1.901 |
| 267 | ARG | 322 | GLU | 1.891 | 0.000 | 1.891 | 1.891 |
| 177 | SER | 258 | MET | 2.861 | 0.977 | 1.884 | 1.884 |
| 385 | ALA | 391 | LEU | 1.845 | 0.000 | 1.845 | 1.845 |
| 141 | THR | 146 | GLY | 3.285 | 5.127 | -1.843 | 1.843 |
| 173 | LEU | 380 | ASN | 1.842 | 0.000 | 1.842 | 1.842 |
| 478 | HIS | 479 | ASP | 1.832 | 0.000 | 1.832 | 1.832 |
| 381 | PRO | 395 | TYR | 0.000 | 1.814 | -1.814 | 1.814 |
| 469 | THR | 470 | THR | 1.953 | 0.151 | 1.802 | 1.802 |
| 159 | ILE | 224 | ASN | 2.985 | 1.192 | 1.794 | 1.794 |
| 171 | MET | 246 | VAL | 1.791 | 0.000 | 1.791 | 1.791 |
| 76 | TYR | 80 | GLU | 0.000 | 1.780 | -1.780 | 1.780 |
| 105 | SER | 395 | TYR | 4.183 | 2.403 | 1.780 | 1.780 |
| 148 | TRP | 155 | CYS | 5.486 | 7.262 | -1.776 | 1.776 |
| 274 | LYS | 315 | ASN | 1.763 | 0.000 | 1.763 | 1.763 |
| 181 | TYR | 185 | THR | 5.392 | 3.629 | 1.763 | 1.763 |
| 70 | CYS | 228 | ASP | 0.000 | 1.758 | -1.758 | 1.758 |
| 74 | ILE | 364 | TRP | 0.000 | 1.751 | -1.751 | 1.751 |
| 108 | PHE | 113 | ARG | 0.000 | 1.744 | -1.744 | 1.744 |
| 230 | VAL | 232 | LEU | 0.136 | 1.864 | -1.728 | 1.728 |
| 335 | ALA | 376 | ASN | 0.122 | 1.842 | -1.721 | 1.721 |
| 354 | CYS | 361 | ILE | 0.038 | 1.748 | -1.709 | 1.709 |
| 73 | GLN | 145 | GLY | 0.000 | 1.706 | -1.706 | 1.706 |
| 164 | MET | 211 | ALA | 1.151 | 2.857 | -1.706 | 1.706 |
| 112 | LEU | 394 | THR | 2.991 | 1.289 | 1.703 | 1.703 |
| 263 | TYR | 329 | LEU | 1.703 | 0.000 | 1.703 | 1.703 |
| 216 | PRO | 222 | ALA | 1.677 | 0.000 | 1.677 | 1.677 |
| 177 | SER | 262 | ILE | 0.447 | 2.116 | -1.669 | 1.669 |
| 176 | ILE | 180 | ARG | 2.010 | 0.344 | 1.666 | 1.666 |
| 113 | ARG | 118 | TYR | 1.861 | 0.205 | 1.656 | 1.656 |
| 361 | ILE | 366 | GLU | 1.644 | 0.000 | 1.644 | 1.644 |
| 285 | SER | 286 | VAL | 0.133 | 1.773 | -1.640 | 1.640 |
| 170 | ILE | 251 | PRO | 0.930 | 2.567 | -1.637 | 1.637 |
| 289 | LEU | 293 | VAL | 1.613 | 0.000 | 1.613 | 1.613 |
| 215 | LEU | 219 | PHE | 2.470 | 0.863 | 1.608 | 1.608 |
| 383 | ILE | 384 | TYR | 1.599 | 0.000 | 1.599 | 1.599 |
| 216 | PRO | 242 | TYR | 0.000 | 1.566 | -1.566 | 1.566 |
| 39 | PRO | 40 | VAL | 0.000 | 1.557 | -1.557 | 1.557 |
| 391 | LEU | 395 | TYR | 1.708 | 0.156 | 1.552 | 1.552 |
| 234 | SER | 239 | TYR | 1.388 | 2.916 | -1.528 | 1.528 |
| 170 | ILE | 248 | PHE | 0.207 | 1.735 | -1.528 | 1.528 |
| 270 | ALA | 319 | PHE | 0.000 | 1.522 | -1.522 | 1.522 |
| 248 | PHE | 252 | MET | 1.262 | 2.779 | -1.518 | 1.518 |
| 37 | ALA | 38 | ASP | 1.833 | 0.319 | 1.514 | 1.514 |
| 259 | TYR | 333 | VAL | 1.513 | 0.008 | 1.505 | 1.505 |
| 383 | ILE | 387 | PHE | 1.921 | 0.421 | 1.500 | 1.500 |
| 259 | TYR | 326 | ALA | 0.000 | 1.495 | -1.495 | 1.495 |
| 155 | CYS | 225 | VAL | 0.000 | 1.492 | -1.492 | 1.492 |
| 161 | MET | 165 | CYS | 0.392 | 1.869 | -1.477 | 1.477 |
| 107 | CYS | 113 | ARG | 3.925 | 5.391 | -1.466 | 1.466 |
| 263 | TYR | 326 | ALA | 1.465 | 0.000 | 1.465 | 1.465 |
| 129 | SER | 161 | MET | 0.000 | 1.461 | -1.461 | 1.461 |
| 174 | CYS | 255 | MET | 0.000 | 1.461 | -1.461 | 1.461 |
| 176 | ILE | 384 | TYR | 1.455 | 0.000 | 1.455 | 1.455 |
| 385 | ALA | 395 | TYR | 0.943 | 2.395 | -1.452 | 1.452 |
| 199 | MET | 202 | MET | 1.838 | 0.389 | 1.448 | 1.448 |
| 222 | ALA | 234 | SER | 5.224 | 3.788 | 1.436 | 1.436 |
| 332 | ILE | 384 | TYR | 0.543 | 1.974 | -1.432 | 1.432 |
| 76 | TYR | 142 | ASP | 0.000 | 1.431 | -1.431 | 1.431 |
| 447 | PRO | 448 | PRO | 0.852 | 2.276 | -1.424 | 1.424 |
| 237 | PHE | 356 | THR | 0.000 | 1.416 | -1.416 | 1.416 |
| 99 | ASN | 128 | LEU | 1.950 | 3.361 | -1.412 | 1.412 |
| 173 | LEU | 255 | MET | 0.041 | 1.452 | -1.410 | 1.410 |
| 170 | ILE | 247 | ALA | 2.506 | 1.096 | 1.410 | 1.410 |
| 141 | THR | 147 | LYS | 1.751 | 3.160 | -1.409 | 1.409 |
| 106 | VAL | 113 | ARG | 1.315 | 2.724 | -1.409 | 1.409 |
| 232 | LEU | 366 | GLU | 0.000 | 1.400 | -1.400 | 1.400 |
| 436 | THR | 440 | LEU | 0.000 | 1.399 | -1.399 | 1.399 |
| 116 | SER | 194 | GLN | 1.076 | 2.465 | -1.389 | 1.389 |
| 259 | TYR | 384 | TYR | 1.378 | 0.000 | 1.378 | 1.378 |
| 148 | TRP | 229 | LYS | 5.741 | 4.365 | 1.376 | 1.376 |
| 180 | ARG | 259 | TYR | 1.369 | 0.000 | 1.369 | 1.369 |
| 122 | SER | 207 | TRP | 1.464 | 2.830 | -1.366 | 1.366 |
| 331 | ILE | 383 | ILE | 0.642 | 1.998 | -1.356 | 1.356 |
| 158 | PHE | 159 | ILE | 0.267 | 1.610 | -1.343 | 1.343 |
| 127 | ASP | 169 | SER | 2.896 | 1.555 | 1.341 | 1.341 |
| 393 | THR | 410 | LEU | 0.000 | 1.337 | -1.337 | 1.337 |
| 127 | ASP | 377 | SER | 10.982 | 9.649 | 1.333 | 1.333 |
| 378 | LEU | 382 | PHE | 0.146 | 1.471 | -1.325 | 1.325 |
| 105 | SER | 112 | LEU | 1.084 | 2.402 | -1.319 | 1.319 |
| 180 | ARG | 322 | GLU | 0.000 | 1.311 | -1.311 | 1.311 |
| 137 | PHE | 154 | PHE | 4.298 | 5.605 | -1.308 | 1.308 |
| 134 | VAL | 158 | PHE | 2.352 | 3.659 | -1.307 | 1.307 |
| 134 | VAL | 162 | ASP | 4.637 | 3.348 | 1.288 | 1.288 |
| 195 | ASN | 198 | CYS | 1.282 | 0.000 | 1.282 | 1.282 |
| 252 | MET | 256 | LEU | 3.042 | 1.763 | 1.279 | 1.279 |
| 173 | LEU | 336 | PHE | 1.273 | 2.540 | -1.266 | 1.266 |
| 194 | GLN | 199 | MET | 1.207 | 2.471 | -1.264 | 1.264 |
| 115 | PRO | 194 | GLN | 2.824 | 1.560 | 1.264 | 1.264 |
| 388 | ASN | 391 | LEU | 4.391 | 5.654 | -1.263 | 1.263 |
| 233 | ILE | 239 | TYR | 1.338 | 2.595 | -1.257 | 1.257 |
| 170 | ILE | 344 | PHE | 1.256 | 0.000 | 1.256 | 1.256 |
| 461 | ASN | 462 | TRP | 1.236 | 0.000 | 1.236 | 1.236 |
| 231 | CYS | 367 | ARG | 0.000 | 1.234 | -1.234 | 1.234 |
| 350 | ARG | 361 | ILE | 0.309 | 1.536 | -1.227 | 1.227 |
| 343 | PHE | 366 | GLU | 0.000 | 1.223 | -1.223 | 1.223 |
| 178 | ILE | 258 | MET | 1.144 | 2.366 | -1.222 | 1.222 |
| 332 | ILE | 383 | ILE | 0.948 | 2.159 | -1.210 | 1.210 |
| 148 | TRP | 154 | PHE | 3.723 | 4.917 | -1.194 | 1.194 |
| 232 | LEU | 367 | ARG | 0.000 | 1.189 | -1.189 | 1.189 |
| 123 | LEU | 173 | LEU | 2.211 | 1.022 | 1.189 | 1.189 |
| 126 | ALA | 169 | SER | 1.171 | 2.347 | -1.176 | 1.176 |
| 9 | ARG | 11 | ASP | 0.000 | 1.176 | -1.176 | 1.176 |
| 161 | MET | 164 | MET | 0.011 | 1.176 | -1.165 | 1.165 |
| 456 | SER | 458 | ASP | 0.000 | 1.161 | -1.161 | 1.161 |
| 106 | VAL | 117 | ASN | 0.053 | 1.212 | -1.160 | 1.160 |
| 273 | HIS | 312 | GLU | 0.000 | 1.156 | -1.156 | 1.156 |
| 242 | TYR | 246 | VAL | 2.009 | 0.855 | 1.154 | 1.154 |
| 204 | LEU | 208 | LEU | 0.000 | 1.152 | -1.152 | 1.152 |
| 274 | LYS | 322 | GLU | 1.147 | 0.000 | 1.147 | 1.147 |
| 80 | GLU | 84 | ILE | 1.224 | 0.088 | 1.136 | 1.136 |
| 112 | LEU | 391 | LEU | 1.748 | 0.614 | 1.134 | 1.134 |
| 297 | LYS | 301 | GLU | 3.151 | 2.018 | 1.133 | 1.133 |
| 162 | ASP | 374 | TYR | 3.820 | 4.953 | -1.133 | 1.133 |
| 257 | PHE | 261 | GLN | 4.560 | 3.434 | 1.127 | 1.127 |
| 235 | GLN | 356 | THR | 0.000 | 1.123 | -1.123 | 1.123 |
| 126 | ALA | 207 | TRP | 1.997 | 3.117 | -1.120 | 1.120 |
| 232 | LEU | 235 | GLN | 1.113 | 0.000 | 1.113 | 1.113 |
| 244 | THR | 249 | TYR | 5.534 | 6.640 | -1.106 | 1.106 |
| 130 | VAL | 165 | CYS | 2.129 | 1.044 | 1.085 | 1.085 |
| 343 | PHE | 370 | LEU | 3.843 | 4.925 | -1.082 | 1.082 |
| 119 | LEU | 199 | MET | 1.140 | 0.060 | 1.079 | 1.079 |
| 339 | CYS | 376 | ASN | 3.235 | 2.156 | 1.078 | 1.078 |
| 224 | ASN | 230 | VAL | 0.000 | 1.073 | -1.073 | 1.073 |
| 118 | TYR | 203 | ILE | 1.451 | 2.520 | -1.068 | 1.068 |
| 135 | MET | 374 | TYR | 3.501 | 2.436 | 1.065 | 1.065 |
| 141 | THR | 148 | TRP | 1.290 | 2.353 | -1.062 | 1.062 |
| 343 | PHE | 347 | SER | 2.704 | 3.764 | -1.060 | 1.060 |
| 141 | THR | 367 | ARG | 1.059 | 0.000 | 1.059 | 1.059 |
| 166 | CYS | 340 | TRP | 1.902 | 2.955 | -1.052 | 1.052 |
| 176 | ILE | 329 | LEU | 0.000 | 1.051 | -1.051 | 1.051 |
| 109 | VAL | 406 | ILE | 0.000 | 1.048 | -1.048 | 1.048 |
| 173 | LEU | 332 | ILE | 0.000 | 1.045 | -1.045 | 1.045 |
| 241 | ILE | 352 | PHE | 0.000 | 1.039 | -1.039 | 1.039 |
| 340 | TRP | 374 | TYR | 0.000 | 1.038 | -1.038 | 1.038 |
| 5 | ASN | 6 | SER | 1.036 | 0.000 | 1.036 | 1.036 |
| 271 | ALA | 322 | GLU | 1.029 | 0.000 | 1.029 | 1.029 |
| 148 | TRP | 228 | ASP | 1.028 | 0.000 | 1.028 | 1.028 |
| 119 | LEU | 176 | ILE | 2.388 | 3.414 | -1.026 | 1.026 |
| 99 | ASN | 127 | ASP | 4.001 | 2.983 | 1.018 | 1.018 |
| 221 | TRP | 239 | TYR | 0.000 | 1.014 | -1.014 | 1.014 |
| 123 | LEU | 172 | THR | 2.759 | 1.748 | 1.011 | 1.011 |
| 213 | ILE | 246 | VAL | 1.465 | 2.472 | -1.007 | 1.007 |
| 101 | LEU | 395 | TYR | 3.400 | 2.413 | 0.987 | 0.987 |
| 245 | ALA | 250 | ILE | 4.747 | 5.730 | -0.983 | 0.983 |
| 248 | PHE | 336 | PHE | 1.882 | 0.901 | 0.982 | 0.982 |
| 88 | LEU | 371 | TRP | 8.963 | 7.982 | 0.981 | 0.981 |
| 225 | VAL | 230 | VAL | 1.089 | 2.070 | -0.981 | 0.981 |
| 102 | VAL | 384 | TYR | 0.000 | 0.964 | -0.964 | 0.964 |
| 100 | CYS | 128 | LEU | 1.422 | 2.385 | -0.963 | 0.963 |
| 148 | TRP | 230 | VAL | 1.023 | 0.060 | 0.963 | 0.963 |
| 365 | VAL | 369 | PHE | 1.730 | 0.768 | 0.962 | 0.962 |
| 60 | TRP | 61 | ASP | 0.961 | 0.000 | 0.961 | 0.961 |
| 55 | SER | 56 | PRO | 1.808 | 0.849 | 0.959 | 0.959 |
| 103 | VAL | 125 | LEU | 1.152 | 0.193 | 0.959 | 0.959 |
| 213 | ILE | 242 | TYR | 0.000 | 0.957 | -0.957 | 0.957 |
| 171 | MET | 251 | PRO | 2.203 | 1.246 | 0.957 | 0.957 |
| 458 | ASP | 459 | HIS | 0.950 | 0.000 | 0.950 | 0.950 |
| 217 | PRO | 224 | ASN | 1.408 | 0.461 | 0.947 | 0.947 |
| 99 | ASN | 381 | PRO | 4.009 | 4.956 | -0.947 | 0.947 |
| 240 | THR | 348 | THR | 0.057 | 0.990 | -0.933 | 0.933 |
| 156 | ASN | 224 | ASN | 3.167 | 4.099 | -0.932 | 0.932 |
| 117 | ASN | 120 | ILE | 0.079 | 1.011 | -0.932 | 0.932 |
| 225 | VAL | 233 | ILE | 0.932 | 0.000 | 0.932 | 0.932 |
| 116 | SER | 117 | ASN | 0.925 | 0.000 | 0.925 | 0.925 |
| 406 | ILE | 410 | LEU | 0.915 | 0.000 | 0.915 | 0.915 |
| 244 | THR | 348 | THR | 2.859 | 3.766 | -0.906 | 0.906 |
| 96 | ILE | 131 | ALA | 2.644 | 1.756 | 0.888 | 0.888 |
| 123 | LEU | 169 | SER | 2.274 | 3.160 | -0.887 | 0.887 |
| 382 | PHE | 386 | PHE | 0.000 | 0.887 | -0.887 | 0.887 |
| 122 | SER | 203 | ILE | 3.580 | 2.699 | 0.882 | 0.882 |
| 125 | LEU | 207 | TRP | 0.000 | 0.880 | -0.880 | 0.880 |
| 99 | ASN | 377 | SER | 1.652 | 2.530 | -0.878 | 0.878 |
| 213 | ILE | 243 | SER | 0.875 | 0.000 | 0.875 | 0.875 |
| 317 | SER | 421 | LEU | 0.000 | 0.875 | -0.875 | 0.875 |
| 137 | PHE | 150 | PHE | 1.609 | 2.482 | -0.873 | 0.873 |
| 123 | LEU | 380 | ASN | 1.876 | 1.004 | 0.873 | 0.873 |
| 252 | MET | 255 | MET | 0.612 | 1.484 | -0.872 | 0.872 |
| 122 | SER | 172 | THR | 1.398 | 2.251 | -0.853 | 0.853 |
| 109 | VAL | 112 | LEU | 1.772 | 2.621 | -0.849 | 0.849 |
| 120 | ILE | 176 | ILE | 0.957 | 0.110 | 0.848 | 0.848 |
| 305 | LEU | 309 | LEU | 0.284 | 1.132 | -0.848 | 0.848 |
| 223 | GLN | 234 | SER | 5.568 | 6.415 | -0.847 | 0.847 |
| 367 | ARG | 370 | LEU | 0.000 | 0.846 | -0.846 | 0.846 |
| 337 | THR | 341 | LEU | 1.192 | 0.349 | 0.843 | 0.843 |
| 117 | ASN | 388 | ASN | 0.838 | 0.000 | 0.838 | 0.838 |
| 384 | TYR | 395 | TYR | 0.000 | 0.834 | -0.834 | 0.834 |
| 233 | ILE | 243 | SER | 0.000 | 0.832 | -0.832 | 0.832 |
| 388 | ASN | 390 | ASP | 1.489 | 0.660 | 0.829 | 0.829 |
| 178 | ILE | 254 | VAL | 0.805 | 0.000 | 0.805 | 0.805 |
| 169 | SER | 380 | ASN | 0.803 | 0.000 | 0.803 | 0.803 |
| 343 | PHE | 344 | PHE | 1.185 | 0.386 | 0.800 | 0.800 |
| 249 | TYR | 344 | PHE | 2.254 | 3.043 | -0.790 | 0.790 |
| 306 | SER | 310 | LYS | 0.789 | 0.000 | 0.789 | 0.789 |
| 139 | SER | 371 | TRP | 2.272 | 3.056 | -0.785 | 0.785 |
| 463 | LEU | 464 | ALA | 0.783 | 0.000 | 0.783 | 0.783 |
| 174 | CYS | 254 | VAL | 1.243 | 0.462 | 0.780 | 0.780 |
| 119 | LEU | 175 | VAL | 1.463 | 2.238 | -0.775 | 0.775 |
| 180 | ARG | 262 | ILE | 1.258 | 0.489 | 0.769 | 0.769 |
| 432 | LEU | 436 | THR | 0.000 | 0.769 | -0.769 | 0.769 |
| 225 | VAL | 231 | CYS | 0.763 | 0.000 | 0.763 | 0.763 |
| 221 | TRP | 242 | TYR | 0.000 | 0.760 | -0.760 | 0.760 |
| 147 | LYS | 229 | LYS | 1.839 | 1.083 | 0.756 | 0.756 |
| 128 | LEU | 132 | VAL | 0.749 | 0.000 | 0.749 | 0.749 |
| 222 | ALA | 239 | TYR | 2.109 | 2.853 | -0.744 | 0.744 |
| 105 | SER | 391 | LEU | 0.000 | 0.742 | -0.742 | 0.742 |
| 328 | THR | 383 | ILE | 0.000 | 0.742 | -0.742 | 0.742 |
| 155 | CYS | 231 | CYS | 7.161 | 6.423 | 0.738 | 0.738 |
| 316 | ILE | 320 | LYS | 1.213 | 0.482 | 0.732 | 0.732 |
| 155 | CYS | 159 | ILE | 1.029 | 0.306 | 0.723 | 0.723 |
| 45 | ALA | 46 | PRO | 0.986 | 0.271 | 0.715 | 0.715 |
| 256 | LEU | 333 | VAL | 1.033 | 0.320 | 0.713 | 0.713 |
| 401 | CYS | 403 | TYR | 0.000 | 0.712 | -0.712 | 0.712 |
| 123 | LEU | 127 | ASP | 1.592 | 0.880 | 0.711 | 0.711 |
| 283 | PRO | 284 | ASP | 0.703 | 0.000 | 0.703 | 0.703 |
| 437 | ARG | 441 | LEU | 0.000 | 0.699 | -0.699 | 0.699 |
| 102 | VAL | 120 | ILE | 0.319 | 1.017 | -0.698 | 0.698 |
| 222 | ALA | 236 | ASP | 0.696 | 0.000 | 0.696 | 0.696 |
| 379 | ILE | 383 | ILE | 0.742 | 1.429 | -0.687 | 0.687 |
| 268 | LYS | 272 | LYS | 0.759 | 0.076 | 0.683 | 0.683 |
| 236 | ASP | 239 | TYR | 0.771 | 1.453 | -0.681 | 0.681 |
| 216 | PRO | 221 | TRP | 4.783 | 4.104 | 0.678 | 0.678 |
| 417 | GLU | 420 | LYS | 0.758 | 0.082 | 0.676 | 0.676 |
| 72 | GLU | 363 | LEU | 0.000 | 0.673 | -0.673 | 0.673 |
| 148 | TRP | 231 | CYS | 6.289 | 6.961 | -0.672 | 0.672 |
| 72 | GLU | 362 | PRO | 0.000 | 0.666 | -0.666 | 0.666 |
| 155 | CYS | 226 | ASN | 0.666 | 0.000 | 0.666 | 0.666 |
| 138 | VAL | 367 | ARG | 0.663 | 0.000 | 0.663 | 0.663 |
| 314 | LYS | 318 | ILE | 0.000 | 0.658 | -0.658 | 0.658 |
| 339 | CYS | 379 | ILE | 0.000 | 0.655 | -0.655 | 0.655 |
| 52 | VAL | 53 | THR | 0.654 | 0.000 | 0.654 | 0.654 |
| 181 | TYR | 182 | LEU | 0.735 | 0.081 | 0.654 | 0.654 |
| 126 | ALA | 165 | CYS | 0.583 | 1.235 | -0.652 | 0.652 |
| 248 | PHE | 341 | LEU | 3.355 | 3.996 | -0.641 | 0.641 |
| 363 | LEU | 367 | ARG | 1.314 | 1.955 | -0.641 | 0.641 |
| 346 | LEU | 369 | PHE | 0.922 | 1.562 | -0.640 | 0.640 |
| 109 | VAL | 398 | LEU | 0.637 | 0.000 | 0.637 | 0.637 |
| 6 | SER | 7 | SER | 0.835 | 0.199 | 0.636 | 0.636 |
| 284 | ASP | 285 | SER | 0.000 | 0.633 | -0.633 | 0.633 |
| 105 | SER | 398 | LEU | 1.039 | 1.670 | -0.631 | 0.631 |
| 398 | LEU | 406 | ILE | 0.000 | 0.629 | -0.629 | 0.629 |
| 173 | LEU | 376 | ASN | 0.628 | 0.000 | 0.628 | 0.628 |
| 163 | VAL | 233 | ILE | 0.732 | 0.106 | 0.626 | 0.626 |
| 225 | VAL | 235 | GLN | 0.620 | 0.000 | 0.620 | 0.620 |
| 339 | CYS | 373 | GLY | 2.521 | 3.140 | -0.618 | 0.618 |
| 104 | ILE | 398 | LEU | 0.000 | 0.618 | -0.618 | 0.618 |
| 259 | TYR | 262 | ILE | 0.686 | 0.070 | 0.616 | 0.616 |
| 32 | SER | 33 | PRO | 1.020 | 0.406 | 0.615 | 0.615 |
| 394 | THR | 406 | ILE | 0.000 | 0.610 | -0.610 | 0.610 |
| 119 | LEU | 172 | THR | 1.029 | 1.638 | -0.608 | 0.608 |
| 269 | SER | 273 | HIS | 0.604 | 0.000 | 0.604 | 0.604 |
| 184 | ILE | 262 | ILE | 1.248 | 0.646 | 0.602 | 0.602 |
| 193 | ARG | 198 | CYS | 0.602 | 0.000 | 0.602 | 0.602 |
| 171 | MET | 206 | VAL | 2.349 | 1.753 | 0.597 | 0.597 |
| 149 | ILE | 150 | PHE | 2.484 | 1.888 | 0.596 | 0.596 |
| 101 | LEU | 105 | SER | 0.595 | 0.000 | 0.595 | 0.595 |
| 153 | PHE | 157 | VAL | 0.913 | 1.507 | -0.594 | 0.594 |
| 160 | ALA | 214 | THR | 3.399 | 3.987 | -0.589 | 0.589 |
| 111 | LYS | 411 | SER | 0.000 | 0.582 | -0.582 | 0.582 |
| 262 | ILE | 326 | ALA | 0.000 | 0.581 | -0.581 | 0.581 |
| 180 | ARG | 332 | ILE | 0.573 | 0.000 | 0.573 | 0.573 |
| 109 | VAL | 410 | LEU | 0.000 | 0.571 | -0.571 | 0.571 |
| 389 | ARG | 392 | ARG | 0.781 | 0.211 | 0.570 | 0.570 |
| 146 | GLY | 363 | LEU | 0.000 | 0.569 | -0.569 | 0.569 |
| 262 | ILE | 329 | LEU | 0.565 | 0.000 | 0.565 | 0.565 |
| 332 | ILE | 387 | PHE | 0.563 | 0.000 | 0.563 | 0.563 |
| 337 | THR | 342 | PRO | 0.798 | 0.237 | 0.560 | 0.560 |
| 209 | LEU | 246 | VAL | 0.560 | 0.000 | 0.560 | 0.560 |
| 332 | ILE | 380 | ASN | 0.000 | 0.558 | -0.558 | 0.558 |
| 383 | ILE | 388 | ASN | 0.000 | 0.557 | -0.557 | 0.557 |
| 397 | SER | 409 | LYS | 0.000 | 0.554 | -0.554 | 0.554 |
| 53 | THR | 54 | ALA | 0.553 | 0.000 | 0.553 | 0.553 |
| 227 | ASP | 228 | ASP | 0.551 | 0.000 | 0.551 | 0.551 |
| 394 | THR | 398 | LEU | 0.462 | 1.010 | -0.548 | 0.548 |
| 384 | TYR | 392 | ARG | 0.000 | 0.544 | -0.544 | 0.544 |
| 232 | LEU | 350 | ARG | 2.586 | 3.127 | -0.541 | 0.541 |
| 224 | ASN | 226 | ASN | 0.535 | 0.000 | 0.535 | 0.535 |
| 28 | LEU | 30 | ASP | 0.531 | 0.000 | 0.531 | 0.531 |
| 123 | LEU | 176 | ILE | 0.702 | 0.172 | 0.530 | 0.530 |
| 95 | THR | 378 | LEU | 6.216 | 5.687 | 0.529 | 0.529 |
| 138 | VAL | 158 | PHE | 1.278 | 1.807 | -0.529 | 0.529 |
| 386 | PHE | 387 | PHE | 0.792 | 1.320 | -0.528 | 0.528 |
| 140 | VAL | 150 | PHE | 0.417 | 0.943 | -0.526 | 0.526 |
| 119 | LEU | 179 | ASP | 1.648 | 1.126 | 0.522 | 0.522 |
| 321 | ARG | 390 | ASP | 0.000 | 0.522 | -0.522 | 0.522 |
| 335 | ALA | 383 | ILE | 0.000 | 0.517 | -0.517 | 0.517 |
| 239 | TYR | 243 | SER | 1.695 | 2.212 | -0.517 | 0.517 |
| 114 | GLN | 116 | SER | 0.511 | 0.000 | 0.511 | 0.511 |
| 114 | GLN | 117 | ASN | 0.387 | 0.899 | -0.511 | 0.511 |
| 224 | ASN | 233 | ILE | 2.310 | 1.808 | 0.502 | 0.502 |
| 466 | LYS | 467 | MET | 0.502 | 0.000 | 0.502 | 0.502 |
| 221 | TRP | 236 | ASP | 0.000 | 0.496 | -0.496 | 0.496 |
| 116 | SER | 199 | MET | 0.000 | 0.495 | -0.495 | 0.495 |
| 254 | VAL | 258 | MET | 0.761 | 0.267 | 0.494 | 0.494 |
| 48 | LEU | 49 | LEU | 2.202 | 1.708 | 0.494 | 0.494 |
| 356 | THR | 357 | SER | 0.000 | 0.494 | -0.494 | 0.494 |
| 319 | PHE | 323 | GLN | 0.902 | 0.410 | 0.492 | 0.492 |
| 164 | MET | 214 | THR | 1.123 | 1.614 | -0.491 | 0.491 |
| 198 | CYS | 199 | MET | 0.489 | 0.000 | 0.489 | 0.489 |
| 389 | ARG | 413 | ALA | 0.000 | 0.489 | -0.489 | 0.489 |
| 130 | VAL | 377 | SER | 0.896 | 0.410 | 0.486 | 0.486 |
| 240 | THR | 351 | PRO | 1.212 | 1.697 | -0.485 | 0.485 |
| 163 | VAL | 213 | ILE | 0.552 | 0.068 | 0.484 | 0.484 |
| 327 | THR | 331 | ILE | 0.693 | 0.210 | 0.483 | 0.483 |
| 10 | PRO | 11 | ASP | 0.000 | 0.479 | -0.479 | 0.479 |
| 183 | GLY | 190 | TYR | 2.409 | 2.888 | -0.479 | 0.479 |
| 112 | LEU | 117 | ASN | 4.708 | 5.183 | -0.475 | 0.475 |
| 115 | PRO | 199 | MET | 3.765 | 4.239 | -0.474 | 0.474 |
| 111 | LYS | 407 | ASN | 0.000 | 0.470 | -0.470 | 0.470 |
| 228 | ASP | 230 | VAL | 0.000 | 0.465 | -0.465 | 0.465 |
| 123 | LEU | 384 | TYR | 1.325 | 0.863 | 0.461 | 0.461 |
| 278 | PHE | 279 | PRO | 1.123 | 0.672 | 0.451 | 0.451 |
| 137 | PHE | 148 | TRP | 0.000 | 0.446 | -0.446 | 0.446 |
| 185 | THR | 265 | ALA | 0.000 | 0.444 | -0.444 | 0.444 |
| 232 | LEU | 358 | CYS | 0.443 | 0.000 | 0.443 | 0.443 |
| 342 | PRO | 372 | LEU | 0.000 | 0.443 | -0.443 | 0.443 |
| 174 | CYS | 178 | ILE | 0.443 | 0.000 | 0.443 | 0.443 |
| 350 | ARG | 351 | PRO | 0.855 | 1.295 | -0.440 | 0.440 |
| 255 | MET | 337 | THR | 0.000 | 0.440 | -0.440 | 0.440 |
| 95 | THR | 377 | SER | 1.861 | 2.300 | -0.438 | 0.438 |
| 185 | THR | 186 | ARG | 0.267 | 0.705 | -0.438 | 0.438 |
| 167 | THR | 210 | SER | 4.512 | 4.946 | -0.434 | 0.434 |
| 106 | VAL | 112 | LEU | 2.632 | 2.200 | 0.432 | 0.432 |
| 112 | LEU | 410 | LEU | 0.000 | 0.432 | -0.432 | 0.432 |
| 339 | CYS | 372 | LEU | 7.495 | 7.924 | -0.429 | 0.429 |
| 49 | LEU | 50 | SER | 0.000 | 0.424 | -0.424 | 0.424 |
| 249 | TYR | 345 | LEU | 1.998 | 2.422 | -0.424 | 0.424 |
| 94 | LEU | 378 | LEU | 1.888 | 2.312 | -0.424 | 0.424 |
| 225 | VAL | 234 | SER | 0.423 | 0.000 | 0.423 | 0.423 |
| 141 | THR | 142 | ASP | 0.417 | 0.000 | 0.417 | 0.417 |
| 159 | ILE | 231 | CYS | 1.343 | 0.926 | 0.417 | 0.417 |
| 174 | CYS | 251 | PRO | 2.088 | 2.503 | -0.414 | 0.414 |
| 92 | THR | 136 | PRO | 0.635 | 0.221 | 0.414 | 0.414 |
| 379 | ILE | 382 | PHE | 0.414 | 0.000 | 0.414 | 0.414 |
| 115 | PRO | 196 | GLY | 0.480 | 0.893 | -0.413 | 0.413 |
| 335 | ALA | 379 | ILE | 0.000 | 0.407 | -0.407 | 0.407 |
| 84 | ILE | 143 | LEU | 0.000 | 0.406 | -0.406 | 0.406 |
| 350 | ARG | 355 | GLY | 0.433 | 0.838 | -0.405 | 0.405 |
| 278 | PHE | 308 | LEU | 0.404 | 0.000 | 0.404 | 0.404 |
| 312 | GLU | 315 | ASN | 0.000 | 0.403 | -0.403 | 0.403 |
| 230 | VAL | 367 | ARG | 0.000 | 0.399 | -0.399 | 0.399 |
| 167 | THR | 213 | ILE | 1.097 | 0.701 | 0.396 | 0.396 |
| 195 | ASN | 197 | LYS | 1.141 | 0.746 | 0.395 | 0.395 |
| 468 | LEU | 469 | THR | 0.392 | 0.000 | 0.392 | 0.392 |
| 275 | PHE | 314 | LYS | 0.391 | 0.000 | 0.391 | 0.391 |
| 260 | TYR | 261 | GLN | 0.063 | 0.454 | -0.391 | 0.391 |
| 181 | TYR | 262 | ILE | 3.040 | 3.431 | -0.391 | 0.391 |
| 54 | ALA | 55 | SER | 0.390 | 0.000 | 0.390 | 0.390 |
| 394 | THR | 410 | LEU | 0.000 | 0.388 | -0.388 | 0.388 |
| 98 | GLY | 395 | TYR | 0.000 | 0.385 | -0.385 | 0.385 |
| 346 | LEU | 365 | VAL | 0.259 | 0.644 | -0.384 | 0.384 |
| 171 | MET | 210 | SER | 0.094 | 0.478 | -0.384 | 0.384 |
| 273 | HIS | 315 | ASN | 0.383 | 0.000 | 0.383 | 0.383 |
| 164 | MET | 210 | SER | 3.969 | 3.589 | 0.380 | 0.380 |
| 111 | LYS | 414 | GLY | 0.000 | 0.380 | -0.380 | 0.380 |
| 333 | VAL | 337 | THR | 0.474 | 0.098 | 0.376 | 0.376 |
| 130 | VAL | 135 | MET | 4.609 | 4.234 | 0.375 | 0.375 |
| 96 | ILE | 128 | LEU | 1.822 | 2.195 | -0.373 | 0.373 |
| 103 | VAL | 128 | LEU | 0.000 | 0.367 | -0.367 | 0.367 |
| 130 | VAL | 166 | CYS | 0.697 | 0.331 | 0.366 | 0.366 |
| 446 | ARG | 447 | PRO | 1.217 | 0.854 | 0.362 | 0.362 |
| 306 | SER | 431 | VAL | 0.000 | 0.361 | -0.361 | 0.361 |
| 394 | THR | 397 | SER | 0.361 | 0.000 | 0.361 | 0.361 |
| 248 | PHE | 340 | TRP | 2.985 | 2.627 | 0.358 | 0.358 |
| 118 | TYR | 199 | MET | 0.839 | 0.482 | 0.357 | 0.357 |
| 70 | CYS | 357 | SER | 0.000 | 0.356 | -0.356 | 0.356 |
| 191 | PRO | 194 | GLN | 0.000 | 0.355 | -0.355 | 0.355 |
| 221 | TRP | 238 | GLY | 0.000 | 0.354 | -0.354 | 0.354 |
| 137 | PHE | 158 | PHE | 1.070 | 0.717 | 0.353 | 0.353 |
| 370 | LEU | 374 | TYR | 5.079 | 5.430 | -0.351 | 0.351 |
| 340 | TRP | 343 | PHE | 0.380 | 0.730 | -0.350 | 0.350 |
| 282 | GLU | 283 | PRO | 0.865 | 0.517 | 0.348 | 0.348 |
| 369 | PHE | 372 | LEU | 0.346 | 0.000 | 0.346 | 0.346 |
| 120 | ILE | 384 | TYR | 1.311 | 1.654 | -0.343 | 0.343 |
| 241 | ILE | 348 | THR | 0.342 | 0.000 | 0.342 | 0.342 |
| 319 | PHE | 322 | GLU | 0.340 | 0.000 | 0.340 | 0.340 |
| 139 | SER | 143 | LEU | 0.334 | 0.000 | 0.334 | 0.334 |
| 244 | THR | 344 | PHE | 1.344 | 1.011 | 0.333 | 0.333 |
| 257 | PHE | 258 | MET | 1.075 | 0.748 | 0.327 | 0.327 |
| 213 | ILE | 247 | ALA | 0.327 | 0.000 | 0.327 | 0.327 |
| 177 | SER | 178 | ILE | 0.326 | 0.000 | 0.326 | 0.326 |
| 166 | CYS | 374 | TYR | 0.320 | 0.000 | 0.320 | 0.320 |
| 177 | SER | 333 | VAL | 0.000 | 0.319 | -0.319 | 0.319 |
| 456 | SER | 457 | PRO | 1.278 | 0.961 | 0.317 | 0.317 |
| 101 | LEU | 398 | LEU | 0.000 | 0.315 | -0.315 | 0.315 |
| 427 | ARG | 430 | PHE | 0.000 | 0.313 | -0.313 | 0.313 |
| 171 | MET | 209 | LEU | 0.975 | 0.666 | 0.309 | 0.309 |
| 294 | LYS | 298 | GLU | 0.309 | 0.000 | 0.309 | 0.309 |
| 102 | VAL | 124 | ALA | 0.889 | 1.197 | -0.308 | 0.308 |
| 353 | ILE | 360 | CYS | 1.326 | 1.019 | 0.308 | 0.308 |
| 466 | LYS | 469 | THR | 0.000 | 0.307 | -0.307 | 0.307 |
| 234 | SER | 236 | ASP | 0.616 | 0.310 | 0.306 | 0.306 |
| 184 | ILE | 322 | GLU | 0.000 | 0.304 | -0.304 | 0.304 |
| 395 | TYR | 398 | LEU | 0.298 | 0.000 | 0.298 | 0.298 |
| 184 | ILE | 326 | ALA | 0.000 | 0.295 | -0.295 | 0.295 |
| 339 | CYS | 375 | ALA | 0.295 | 0.000 | 0.295 | 0.295 |
| 256 | LEU | 337 | THR | 0.000 | 0.292 | -0.292 | 0.292 |
| 226 | ASN | 232 | LEU | 0.130 | 0.422 | -0.292 | 0.292 |
| 371 | TRP | 374 | TYR | 1.543 | 1.252 | 0.291 | 0.291 |
| 235 | GLN | 240 | THR | 1.751 | 1.466 | 0.285 | 0.285 |
| 106 | VAL | 391 | LEU | 0.284 | 0.000 | 0.284 | 0.284 |
| 118 | TYR | 196 | GLY | 1.321 | 1.603 | -0.281 | 0.281 |
| 172 | THR | 206 | VAL | 1.096 | 1.376 | -0.280 | 0.280 |
| 240 | THR | 347 | SER | 1.237 | 0.957 | 0.280 | 0.280 |
| 221 | TRP | 222 | ALA | 0.279 | 0.000 | 0.279 | 0.279 |
| 381 | PRO | 386 | PHE | 0.279 | 0.000 | 0.279 | 0.279 |
| 95 | THR | 135 | MET | 1.340 | 1.066 | 0.275 | 0.275 |
| 112 | LEU | 390 | ASP | 0.213 | 0.487 | -0.274 | 0.274 |
| 227 | ASP | 230 | VAL | 0.274 | 0.000 | 0.274 | 0.274 |
| 233 | ILE | 235 | GLN | 0.724 | 0.452 | 0.273 | 0.273 |
| 244 | THR | 347 | SER | 0.273 | 0.000 | 0.273 | 0.273 |
| 86 | SER | 87 | ILE | 0.000 | 0.271 | -0.271 | 0.271 |
| 95 | THR | 131 | ALA | 1.506 | 1.235 | 0.271 | 0.271 |
| 363 | LEU | 366 | GLU | 0.268 | 0.000 | 0.268 | 0.268 |
| 427 | ARG | 428 | PRO | 0.422 | 0.160 | 0.262 | 0.262 |
| 21 | LEU | 22 | PRO | 0.460 | 0.198 | 0.262 | 0.262 |
| 346 | LEU | 366 | GLU | 1.566 | 1.828 | -0.262 | 0.262 |
| 88 | LEU | 142 | ASP | 0.261 | 0.000 | 0.261 | 0.261 |
| 312 | GLU | 316 | ILE | 0.255 | 0.000 | 0.255 | 0.255 |
| 92 | THR | 135 | MET | 1.896 | 2.148 | -0.252 | 0.252 |
| 239 | TYR | 242 | TYR | 0.000 | 0.251 | -0.251 | 0.251 |
| 115 | PRO | 195 | ASN | 1.460 | 1.212 | 0.248 | 0.248 |
| 328 | THR | 332 | ILE | 0.553 | 0.307 | 0.246 | 0.246 |
| 61 | ASP | 62 | ALA | 0.244 | 0.000 | 0.244 | 0.244 |
| 364 | TRP | 365 | VAL | 4.917 | 4.677 | 0.240 | 0.240 |
| 107 | CYS | 108 | PHE | 0.058 | 0.296 | -0.238 | 0.238 |
| 148 | TRP | 150 | PHE | 3.961 | 4.198 | -0.237 | 0.237 |
| 90 | LEU | 94 | LEU | 1.373 | 1.603 | -0.230 | 0.230 |
| 212 | SER | 213 | ILE | 0.089 | 0.319 | -0.229 | 0.229 |
| 89 | THR | 139 | SER | 0.229 | 0.000 | 0.229 | 0.229 |
| 103 | VAL | 124 | ALA | 0.758 | 0.529 | 0.229 | 0.229 |
| 338 | VAL | 372 | LEU | 0.407 | 0.632 | -0.225 | 0.225 |
| 380 | ASN | 384 | TYR | 0.497 | 0.273 | 0.224 | 0.224 |
| 404 | ARG | 405 | ASN | 0.000 | 0.223 | -0.223 | 0.223 |
| 288 | ALA | 294 | LYS | 0.000 | 0.221 | -0.221 | 0.221 |
| 362 | PRO | 364 | TRP | 2.774 | 2.995 | -0.221 | 0.221 |
| 217 | PRO | 239 | TYR | 4.962 | 4.742 | 0.220 | 0.220 |
| 392 | ARG | 396 | ARG | 0.978 | 0.758 | 0.220 | 0.220 |
| 293 | VAL | 297 | LYS | 0.219 | 0.000 | 0.219 | 0.219 |
| 237 | PHE | 241 | ILE | 0.218 | 0.000 | 0.218 | 0.218 |
| 169 | SER | 376 | ASN | 0.218 | 0.000 | 0.218 | 0.218 |
| 323 | GLN | 327 | THR | 0.218 | 0.000 | 0.218 | 0.218 |
| 92 | THR | 131 | ALA | 1.231 | 1.446 | -0.215 | 0.215 |
| 130 | VAL | 374 | TYR | 1.311 | 1.524 | -0.213 | 0.213 |
| 190 | TYR | 199 | MET | 0.322 | 0.532 | -0.211 | 0.211 |
| 214 | THR | 239 | TYR | 0.210 | 0.000 | 0.210 | 0.210 |
| 324 | LYS | 387 | PHE | 0.000 | 0.209 | -0.209 | 0.209 |
| 169 | SER | 336 | PHE | 0.000 | 0.209 | -0.209 | 0.209 |
| 162 | ASP | 166 | CYS | 1.508 | 1.301 | 0.206 | 0.206 |
| 384 | TYR | 388 | ASN | 0.000 | 0.204 | -0.204 | 0.204 |
| 173 | LEU | 176 | ILE | 0.000 | 0.203 | -0.203 | 0.203 |
| 247 | ALA | 344 | PHE | 0.453 | 0.251 | 0.201 | 0.201 |
| 146 | GLY | 229 | LYS | 0.372 | 0.172 | 0.200 | 0.200 |
| 180 | ARG | 194 | GLN | 0.000 | 0.198 | -0.198 | 0.198 |
| 103 | VAL | 107 | CYS | 0.240 | 0.438 | -0.198 | 0.198 |
| 131 | ALA | 136 | PRO | 2.238 | 2.041 | 0.197 | 0.197 |
| 164 | MET | 165 | CYS | 0.000 | 0.196 | -0.196 | 0.196 |
| 368 | THR | 372 | LEU | 0.196 | 0.000 | 0.196 | 0.196 |
| 163 | VAL | 247 | ALA | 0.000 | 0.196 | -0.196 | 0.196 |
| 360 | CYS | 361 | ILE | 0.000 | 0.195 | -0.195 | 0.195 |
| 361 | ILE | 362 | PRO | 1.078 | 0.883 | 0.195 | 0.195 |
| 261 | GLN | 264 | LYS | 0.334 | 0.528 | -0.195 | 0.195 |
| 73 | GLN | 75 | ASN | 0.000 | 0.195 | -0.195 | 0.195 |
| 353 | ILE | 361 | ILE | 0.194 | 0.000 | 0.194 | 0.194 |
| 442 | ARG | 444 | GLU | 0.189 | 0.000 | 0.189 | 0.189 |
| 353 | ILE | 354 | CYS | 0.000 | 0.188 | -0.188 | 0.188 |
| 168 | ALA | 210 | SER | 4.017 | 4.205 | -0.188 | 0.188 |
| 146 | GLY | 367 | ARG | 0.187 | 0.000 | 0.187 | 0.187 |
| 138 | VAL | 142 | ASP | 1.193 | 1.377 | -0.184 | 0.184 |
| 364 | TRP | 368 | THR | 0.248 | 0.432 | -0.184 | 0.184 |
| 172 | THR | 176 | ILE | 0.510 | 0.693 | -0.183 | 0.183 |
| 442 | ARG | 443 | PRO | 0.318 | 0.500 | -0.183 | 0.183 |
| 368 | THR | 369 | PHE | 0.182 | 0.000 | 0.182 | 0.182 |
| 181 | TYR | 265 | ALA | 0.000 | 0.180 | -0.180 | 0.180 |
| 109 | VAL | 394 | THR | 1.455 | 1.635 | -0.180 | 0.180 |
| 99 | ASN | 102 | VAL | 0.000 | 0.178 | -0.178 | 0.178 |
| 83 | VAL | 87 | ILE | 0.688 | 0.514 | 0.175 | 0.175 |
| 158 | PHE | 231 | CYS | 0.315 | 0.490 | -0.175 | 0.175 |
| 85 | GLY | 143 | LEU | 1.419 | 1.593 | -0.174 | 0.174 |
| 63 | PRO | 64 | PRO | 0.960 | 0.787 | 0.173 | 0.173 |
| 100 | CYS | 104 | ILE | 0.187 | 0.014 | 0.173 | 0.173 |
| 109 | VAL | 111 | LYS | 0.316 | 0.144 | 0.172 | 0.172 |
| 95 | THR | 128 | LEU | 0.000 | 0.172 | -0.172 | 0.172 |
| 248 | PHE | 249 | TYR | 2.490 | 2.320 | 0.171 | 0.171 |
| 145 | GLY | 363 | LEU | 0.000 | 0.170 | -0.170 | 0.170 |
| 62 | ALA | 63 | PRO | 0.775 | 0.607 | 0.168 | 0.168 |
| 274 | LYS | 318 | ILE | 0.166 | 0.000 | 0.166 | 0.166 |
| 170 | ILE | 171 | MET | 0.000 | 0.166 | -0.166 | 0.166 |
| 169 | SER | 377 | SER | 0.166 | 0.000 | 0.166 | 0.166 |
| 313 | ARG | 421 | LEU | 0.000 | 0.162 | -0.162 | 0.162 |
| 362 | PRO | 365 | VAL | 0.792 | 0.630 | 0.162 | 0.162 |
| 158 | PHE | 374 | TYR | 0.000 | 0.161 | -0.161 | 0.161 |
| 75 | ASN | 80 | GLU | 0.000 | 0.161 | -0.161 | 0.161 |
| 163 | VAL | 167 | THR | 0.306 | 0.466 | -0.160 | 0.160 |
| 190 | TYR | 191 | PRO | 1.021 | 1.181 | -0.160 | 0.160 |
| 243 | SER | 244 | THR | 0.186 | 0.345 | -0.159 | 0.159 |
| 96 | ILE | 132 | VAL | 0.669 | 0.827 | -0.158 | 0.158 |
| 188 | LEU | 189 | THR | 0.158 | 0.000 | 0.158 | 0.158 |
| 184 | ILE | 319 | PHE | 0.000 | 0.157 | -0.157 | 0.157 |
| 313 | ARG | 422 | ALA | 0.000 | 0.157 | -0.157 | 0.157 |
| 328 | THR | 388 | ASN | 0.000 | 0.157 | -0.157 | 0.157 |
| 135 | MET | 371 | TRP | 1.026 | 1.183 | -0.157 | 0.157 |
| 95 | THR | 99 | ASN | 0.994 | 0.837 | 0.156 | 0.156 |
| 376 | ASN | 379 | ILE | 0.156 | 0.000 | 0.156 | 0.156 |
| 114 | GLN | 115 | PRO | 0.834 | 0.680 | 0.154 | 0.154 |
| 104 | ILE | 108 | PHE | 1.561 | 1.408 | 0.153 | 0.153 |
| 245 | ALA | 251 | PRO | 0.435 | 0.588 | -0.153 | 0.153 |
| 155 | CYS | 232 | LEU | 0.318 | 0.166 | 0.152 | 0.152 |
| 126 | ALA | 168 | ALA | 0.638 | 0.488 | 0.150 | 0.150 |
| 318 | ILE | 322 | GLU | 0.000 | 0.149 | -0.149 | 0.149 |
| 166 | CYS | 336 | PHE | 0.000 | 0.148 | -0.148 | 0.148 |
| 89 | THR | 93 | LEU | 0.410 | 0.555 | -0.145 | 0.145 |
| 138 | VAL | 141 | THR | 0.145 | 0.000 | 0.145 | 0.145 |
| 101 | LEU | 399 | LEU | 0.000 | 0.145 | -0.145 | 0.145 |
| 103 | VAL | 121 | VAL | 0.156 | 0.301 | -0.145 | 0.145 |
| 449 | VAL | 451 | VAL | 0.142 | 0.000 | 0.142 | 0.142 |
| 59 | THR | 61 | ASP | 0.000 | 0.141 | -0.141 | 0.141 |
| 382 | PHE | 387 | PHE | 0.140 | 0.000 | 0.140 | 0.140 |
| 120 | ILE | 391 | LEU | 0.140 | 0.000 | 0.140 | 0.140 |
| 393 | THR | 394 | THR | 0.139 | 0.000 | 0.139 | 0.139 |
| 182 | LEU | 187 | PRO | 0.137 | 0.000 | 0.137 | 0.137 |
| 74 | ILE | 367 | ARG | 0.000 | 0.136 | -0.136 | 0.136 |
| 361 | ILE | 365 | VAL | 0.509 | 0.374 | 0.135 | 0.135 |
| 380 | ASN | 383 | ILE | 0.000 | 0.131 | -0.131 | 0.131 |
| 375 | ALA | 379 | ILE | 0.000 | 0.127 | -0.127 | 0.127 |
| 127 | ASP | 381 | PRO | 0.125 | 0.000 | 0.125 | 0.125 |
| 246 | VAL | 251 | PRO | 2.366 | 2.491 | -0.124 | 0.124 |
| 138 | VAL | 371 | TRP | 1.954 | 2.078 | -0.124 | 0.124 |
| 226 | ASN | 350 | ARG | 0.000 | 0.123 | -0.123 | 0.123 |
| 175 | VAL | 206 | VAL | 0.779 | 0.657 | 0.122 | 0.122 |
| 336 | PHE | 341 | LEU | 0.213 | 0.091 | 0.122 | 0.122 |
| 92 | THR | 371 | TRP | 0.120 | 0.000 | 0.120 | 0.120 |
| 134 | VAL | 161 | MET | 0.174 | 0.293 | -0.120 | 0.120 |
| 186 | ARG | 191 | PRO | 0.854 | 0.736 | 0.118 | 0.118 |
| 141 | THR | 150 | PHE | 0.125 | 0.242 | -0.117 | 0.117 |
| 102 | VAL | 381 | PRO | 0.540 | 0.424 | 0.116 | 0.116 |
| 134 | VAL | 138 | VAL | 0.273 | 0.389 | -0.116 | 0.116 |
| 88 | LEU | 139 | SER | 2.084 | 2.200 | -0.116 | 0.116 |
| 150 | PHE | 154 | PHE | 3.222 | 3.337 | -0.115 | 0.115 |
| 317 | SER | 318 | ILE | 0.311 | 0.196 | 0.115 | 0.115 |
| 348 | THR | 352 | PHE | 0.000 | 0.113 | -0.113 | 0.113 |
| 300 | GLU | 304 | ASN | 0.505 | 0.618 | -0.113 | 0.113 |
| 125 | LEU | 128 | LEU | 0.000 | 0.110 | -0.110 | 0.110 |
| 346 | LEU | 361 | ILE | 2.360 | 2.252 | 0.108 | 0.108 |
| 451 | VAL | 453 | VAL | 0.120 | 0.015 | 0.105 | 0.105 |
| 242 | TYR | 243 | SER | 0.000 | 0.104 | -0.104 | 0.104 |
| 162 | ASP | 370 | LEU | 0.000 | 0.103 | -0.103 | 0.103 |
| 167 | THR | 171 | MET | 0.598 | 0.496 | 0.102 | 0.102 |
| 184 | ILE | 265 | ALA | 0.306 | 0.407 | -0.101 | 0.101 |
| 471 | VAL | 475 | VAL | 0.000 | 0.100 | -0.100 | 0.100 |
| 397 | SER | 398 | LEU | 0.099 | 0.000 | 0.099 | 0.099 |
| 351 | PRO | 356 | THR | 0.000 | 0.097 | -0.097 | 0.097 |
| 159 | ILE | 163 | VAL | 0.195 | 0.291 | -0.097 | 0.097 |
| 117 | ASN | 391 | LEU | 0.094 | 0.000 | 0.094 | 0.094 |
| 134 | VAL | 374 | TYR | 2.422 | 2.516 | -0.093 | 0.093 |
| 92 | THR | 139 | SER | 0.000 | 0.093 | -0.093 | 0.093 |
| 324 | LYS | 328 | THR | 0.093 | 0.000 | 0.093 | 0.093 |
| 102 | VAL | 395 | TYR | 3.965 | 4.053 | -0.088 | 0.088 |
| 184 | ILE | 266 | ALA | 0.000 | 0.088 | -0.088 | 0.088 |
| 250 | ILE | 254 | VAL | 0.088 | 0.000 | 0.088 | 0.088 |
| 397 | SER | 403 | TYR | 0.000 | 0.088 | -0.088 | 0.088 |
| 169 | SER | 173 | LEU | 0.087 | 0.000 | 0.087 | 0.087 |
| 144 | ILE | 147 | LYS | 0.000 | 0.087 | -0.087 | 0.087 |
| 170 | ILE | 255 | MET | 0.000 | 0.086 | -0.086 | 0.086 |
| 171 | MET | 247 | ALA | 0.084 | 0.000 | 0.084 | 0.084 |
| 203 | ILE | 207 | TRP | 1.254 | 1.336 | -0.082 | 0.082 |
| 405 | ASN | 409 | LYS | 0.031 | 0.112 | -0.081 | 0.081 |
| 82 | VAL | 86 | SER | 0.080 | 0.000 | 0.080 | 0.080 |
| 87 | ILE | 91 | ILE | 0.745 | 0.665 | 0.079 | 0.079 |
| 472 | GLU | 476 | MET | 0.000 | 0.079 | -0.079 | 0.079 |
| 329 | LEU | 332 | ILE | 0.000 | 0.077 | -0.077 | 0.077 |
| 154 | PHE | 158 | PHE | 0.081 | 0.005 | 0.076 | 0.076 |
| 140 | VAL | 144 | ILE | 0.899 | 0.823 | 0.076 | 0.076 |
| 349 | ALA | 353 | ILE | 0.755 | 0.831 | -0.076 | 0.076 |
| 260 | TYR | 264 | LYS | 0.079 | 0.004 | 0.075 | 0.075 |
| 104 | ILE | 109 | VAL | 0.000 | 0.074 | -0.074 | 0.074 |
| 80 | GLU | 85 | GLY | 0.000 | 0.073 | -0.073 | 0.073 |
| 168 | ALA | 207 | TRP | 1.698 | 1.771 | -0.073 | 0.073 |
| 47 | HIS | 48 | LEU | 0.073 | 0.000 | 0.073 | 0.073 |
| 140 | VAL | 149 | ILE | 0.016 | 0.088 | -0.072 | 0.072 |
| 29 | PRO | 30 | ASP | 0.072 | 0.000 | 0.072 | 0.072 |
| 133 | ALA | 134 | VAL | 0.000 | 0.071 | -0.071 | 0.071 |
| 302 | CYS | 431 | VAL | 0.000 | 0.071 | -0.071 | 0.071 |
| 212 | SER | 215 | LEU | 0.272 | 0.202 | 0.071 | 0.071 |
| 241 | ILE | 244 | THR | 0.069 | 0.000 | 0.069 | 0.069 |
| 311 | HIS | 312 | GLU | 0.000 | 0.069 | -0.069 | 0.069 |
| 315 | ASN | 318 | ILE | 0.068 | 0.000 | 0.068 | 0.068 |
| 275 | PHE | 276 | PRO | 0.512 | 0.444 | 0.067 | 0.067 |
| 389 | ARG | 390 | ASP | 0.067 | 0.000 | 0.067 | 0.067 |
| 234 | SER | 240 | THR | 1.125 | 1.059 | 0.066 | 0.066 |
| 428 | PRO | 433 | ARG | 0.000 | 0.066 | -0.066 | 0.066 |
| 57 | ALA | 58 | PRO | 0.724 | 0.790 | -0.065 | 0.065 |
| 133 | ALA | 158 | PHE | 0.189 | 0.254 | -0.064 | 0.064 |
| 168 | ALA | 206 | VAL | 1.051 | 1.113 | -0.063 | 0.063 |
| 350 | ARG | 354 | CYS | 0.000 | 0.062 | -0.062 | 0.062 |
| 380 | ASN | 385 | ALA | 0.061 | 0.000 | 0.061 | 0.061 |
| 243 | SER | 248 | PHE | 0.018 | 0.079 | -0.061 | 0.061 |
| 51 | GLU | 53 | THR | 0.000 | 0.061 | -0.061 | 0.061 |
| 246 | VAL | 250 | ILE | 0.000 | 0.060 | -0.060 | 0.060 |
| 250 | ILE | 251 | PRO | 1.375 | 1.315 | 0.060 | 0.060 |
| 96 | ILE | 100 | CYS | 0.361 | 0.303 | 0.058 | 0.058 |
| 163 | VAL | 214 | THR | 1.199 | 1.257 | -0.058 | 0.058 |
| 190 | TYR | 202 | MET | 0.057 | 0.000 | 0.057 | 0.057 |
| 215 | LEU | 218 | LEU | 0.062 | 0.118 | -0.056 | 0.056 |
| 84 | ILE | 88 | LEU | 1.047 | 1.102 | -0.055 | 0.055 |
| 354 | CYS | 359 | SER | 0.770 | 0.821 | -0.051 | 0.051 |
| 432 | LEU | 437 | ARG | 0.000 | 0.050 | -0.050 | 0.050 |
| 229 | LYS | 230 | VAL | 0.050 | 0.000 | 0.050 | 0.050 |
| 79 | VAL | 83 | VAL | 0.201 | 0.152 | 0.049 | 0.049 |
| 249 | TYR | 348 | THR | 4.737 | 4.785 | -0.048 | 0.048 |
| 339 | CYS | 340 | TRP | 0.175 | 0.129 | 0.046 | 0.046 |
| 455 | GLN | 457 | PRO | 0.000 | 0.046 | -0.046 | 0.046 |
| 424 | ARG | 425 | PRO | 0.415 | 0.370 | 0.045 | 0.045 |
| 18 | SER | 19 | PHE | 0.580 | 0.538 | 0.043 | 0.043 |
| 230 | VAL | 363 | LEU | 0.000 | 0.042 | -0.042 | 0.042 |
| 130 | VAL | 134 | VAL | 0.336 | 0.295 | 0.041 | 0.041 |
| 228 | ASP | 229 | LYS | 0.040 | 0.000 | 0.040 | 0.040 |
| 295 | LEU | 439 | VAL | 0.000 | 0.038 | -0.038 | 0.038 |
| 186 | ARG | 190 | TYR | 0.351 | 0.389 | -0.038 | 0.038 |
| 174 | CYS | 177 | SER | 0.038 | 0.000 | 0.038 | 0.038 |
| 130 | VAL | 136 | PRO | 0.064 | 0.026 | 0.037 | 0.037 |
| 403 | TYR | 406 | ILE | 0.000 | 0.037 | -0.037 | 0.037 |
| 175 | VAL | 202 | MET | 0.896 | 0.861 | 0.035 | 0.035 |
| 380 | ASN | 381 | PRO | 0.975 | 1.010 | -0.035 | 0.035 |
| 266 | ALA | 322 | GLU | 0.034 | 0.000 | 0.034 | 0.034 |
| 179 | ASP | 199 | MET | 1.195 | 1.230 | -0.034 | 0.034 |
| 132 | VAL | 137 | PHE | 0.182 | 0.148 | 0.034 | 0.034 |
| 178 | ILE | 182 | LEU | 0.721 | 0.686 | 0.034 | 0.034 |
| 106 | VAL | 121 | VAL | 1.963 | 1.996 | -0.033 | 0.033 |
| 91 | ILE | 371 | TRP | 0.033 | 0.000 | 0.033 | 0.033 |
| 138 | VAL | 370 | LEU | 0.276 | 0.244 | 0.032 | 0.032 |
| 167 | THR | 247 | ALA | 2.076 | 2.107 | -0.031 | 0.031 |
| 198 | CYS | 202 | MET | 0.201 | 0.171 | 0.030 | 0.030 |
| 240 | THR | 244 | THR | 0.208 | 0.237 | -0.029 | 0.029 |
| 91 | ILE | 378 | LEU | 0.702 | 0.729 | -0.027 | 0.027 |
| 186 | ARG | 187 | PRO | 0.094 | 0.121 | -0.027 | 0.027 |
| 341 | LEU | 342 | PRO | 0.898 | 0.924 | -0.026 | 0.026 |
| 95 | THR | 127 | ASP | 0.331 | 0.306 | 0.025 | 0.025 |
| 343 | PHE | 369 | PHE | 4.317 | 4.292 | 0.025 | 0.025 |
| 163 | VAL | 239 | TYR | 0.024 | 0.000 | 0.024 | 0.024 |
| 177 | SER | 254 | VAL | 0.024 | 0.000 | 0.024 | 0.024 |
| 279 | PRO | 281 | VAL | 0.000 | 0.023 | -0.023 | 0.023 |
| 314 | LYS | 317 | SER | 0.023 | 0.000 | 0.023 | 0.023 |
| 470 | THR | 472 | GLU | 0.022 | 0.000 | 0.022 | 0.022 |
| 209 | LEU | 213 | ILE | 0.000 | 0.022 | -0.022 | 0.022 |
| 313 | ARG | 424 | ARG | 0.000 | 0.021 | -0.021 | 0.021 |
| 186 | ARG | 189 | THR | 0.021 | 0.000 | 0.021 | 0.021 |
| 99 | ASN | 380 | ASN | 0.000 | 0.021 | -0.021 | 0.021 |
| 223 | GLN | 232 | LEU | 0.000 | 0.020 | -0.020 | 0.020 |
| 339 | CYS | 369 | PHE | 0.371 | 0.390 | -0.020 | 0.020 |
| 209 | LEU | 212 | SER | 0.599 | 0.619 | -0.020 | 0.020 |
| 240 | THR | 245 | ALA | 0.000 | 0.020 | -0.020 | 0.020 |
| 367 | ARG | 371 | TRP | 0.027 | 0.008 | 0.019 | 0.019 |
| 108 | PHE | 407 | ASN | 0.000 | 0.018 | -0.018 | 0.018 |
| 131 | ALA | 135 | MET | 0.608 | 0.590 | 0.017 | 0.017 |
| 459 | HIS | 460 | HIS | 0.016 | 0.000 | 0.016 | 0.016 |
| 162 | ASP | 340 | TRP | 0.000 | 0.016 | -0.016 | 0.016 |
| 119 | LEU | 202 | MET | 0.016 | 0.000 | 0.016 | 0.016 |
| 287 | ILE | 288 | ALA | 0.000 | 0.016 | -0.016 | 0.016 |
| 110 | LYS | 113 | ARG | 0.000 | 0.016 | -0.016 | 0.016 |
| 205 | SER | 206 | VAL | 0.000 | 0.015 | -0.015 | 0.015 |
| 129 | SER | 207 | TRP | 0.180 | 0.194 | -0.014 | 0.014 |
| 91 | ILE | 95 | THR | 0.293 | 0.307 | -0.014 | 0.014 |
| 129 | SER | 165 | CYS | 1.345 | 1.332 | 0.013 | 0.013 |
| 340 | TRP | 344 | PHE | 2.636 | 2.649 | -0.013 | 0.013 |
| 135 | MET | 136 | PRO | 0.788 | 0.775 | 0.013 | 0.013 |
| 119 | LEU | 203 | ILE | 1.172 | 1.184 | -0.012 | 0.012 |
| 389 | ARG | 393 | THR | 0.182 | 0.194 | -0.012 | 0.012 |
| 182 | LEU | 185 | THR | 0.000 | 0.011 | -0.011 | 0.011 |
| 142 | ASP | 371 | TRP | 3.183 | 3.194 | -0.011 | 0.011 |
| 129 | SER | 134 | VAL | 0.644 | 0.654 | -0.010 | 0.010 |
| 135 | MET | 377 | SER | 0.524 | 0.534 | -0.010 | 0.010 |
| 92 | THR | 96 | ILE | 0.389 | 0.398 | -0.009 | 0.009 |
| 138 | VAL | 374 | TYR | 1.875 | 1.866 | 0.009 | 0.009 |
| 341 | LEU | 345 | LEU | 2.536 | 2.528 | 0.009 | 0.009 |
| 121 | VAL | 125 | LEU | 0.645 | 0.652 | -0.007 | 0.007 |
| 459 | HIS | 462 | TRP | 0.000 | 0.007 | -0.007 | 0.007 |
| 216 | PRO | 217 | PRO | 2.030 | 2.024 | 0.006 | 0.006 |
| 393 | THR | 397 | SER | 0.000 | 0.006 | -0.006 | 0.006 |
| 144 | ILE | 149 | ILE | 0.662 | 0.668 | -0.005 | 0.005 |
| 429 | GLU | 434 | ALA | 0.000 | 0.005 | -0.005 | 0.005 |
| 304 | ASN | 307 | ARG | 0.188 | 0.193 | -0.005 | 0.005 |
| 115 | PRO | 118 | TYR | 0.005 | 0.000 | 0.005 | 0.005 |
| 206 | VAL | 210 | SER | 0.321 | 0.318 | 0.003 | 0.003 |
| 156 | ASN | 218 | LEU | 0.000 | 0.002 | -0.002 | 0.002 |
| 215 | LEU | 216 | PRO | 0.765 | 0.766 | -0.001 | 0.001 |
RRCS change distribution
-0.19
Mean ΔRRCS
1.74
Std Dev
-0.04
Median
Magnitude classification
33
High (|Δ| ≥ 5.0)
49
Medium (2.4 ≤ |Δ| < 5.0)
720
Low (|Δ| < 2.4)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.44, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar