ADA1A
783
Total Contact Pairs
89
Significant Changes
7.75
Max Increase
-9.51
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | ARG238 | GLU461 | 0.000 | 9.514 | -9.514 | HIGH |
| 2 | PHE281 (6.44x44) | TRP285 (6.48x48) | 2.261 | 10.513 | -8.252 | HIGH |
| 3 | THR273 (6.36x36) | SER329 (7.56x56) | 0.000 | 8.163 | -8.163 | HIGH |
| 4 | PRO327 (7.54x54) | PHE333 (8.50x50) | 8.483 | 0.731 | +7.753 | HIGH |
| 5 | PHE82 (2.60x59) | PHE98 (3.24x24) | 0.000 | 7.245 | -7.245 | HIGH |
| 6 | LEU57 (12.50x50) | HIS62 (2.40x40) | 8.418 | 15.208 | -6.791 | HIGH |
| 7 | GLY221 (5.75x75) | ILE236 | 0.000 | 6.684 | -6.684 | HIGH |
| 8 | ASP72 (2.50x50) | SER319 (7.46x46) | 10.457 | 3.872 | +6.584 | HIGH |
| 9 | ASN339 (8.56x56) | GLN344 | 0.000 | 5.911 | -5.911 | HIGH |
| 10 | HIS371 | LYS372 | 5.862 | 0.000 | +5.862 | HIGH |
| 11 | PHE281 (6.44x44) | ASN318 (7.45x45) | 0.649 | 6.389 | -5.740 | HIGH |
| 12 | SER458 | VAL466 | 4.085 | 9.700 | -5.615 | HIGH |
| 13 | PHE385 | PHE399 | 0.000 | 5.604 | -5.604 | HIGH |
| 14 | SER215 (5.69x69) | LYS263 (6.26x26) | 5.521 | 0.000 | +5.521 | HIGH |
| 15 | LEU132 (34.51x51) | ARG260 | 0.000 | 5.457 | -5.457 | HIGH |
| 16 | HIS237 | LEU459 | 0.000 | 5.033 | -5.033 | HIGH |
| 17 | ASP172 | THR174 | 5.577 | 0.561 | +5.015 | HIGH |
| 18 | SER215 (5.69x69) | GLU267 (6.30x30) | 4.993 | 0.000 | +4.993 | MED |
| 19 | ILE114 (3.40x40) | TRP285 (6.48x48) | 4.923 | 0.000 | +4.923 | MED |
| 20 | THR61 (2.39x39) | ARG124 (3.50x50) | 0.000 | 4.907 | -4.907 | MED |
| 21 | VAL47 (1.53x53) | PHE333 (8.50x50) | 4.839 | 0.000 | +4.839 | MED |
| 22 | HIS58 (12.51x51) | TYR63 (2.41x41) | 4.727 | 0.000 | +4.727 | MED |
| 23 | TYR204 (5.58x58) | GLY275 (6.38x38) | 0.000 | 4.610 | -4.610 | MED |
| 24 | LEU117 (3.43x43) | TYR326 (7.53x53) | 4.579 | 0.000 | +4.579 | MED |
| 25 | LYS223 | LEU234 | 0.000 | 4.479 | -4.479 | MED |
| 26 | GLY217 (5.71x71) | LEU222 (5.76x76) | 0.000 | 4.437 | -4.437 | MED |
| 27 | TYR125 (3.51x51) | ARG206 (5.60x60) | 6.879 | 2.501 | +4.378 | MED |
| 28 | GLU214 (5.68x68) | LYS223 | 0.000 | 4.328 | -4.328 | MED |
| 29 | ASP123 (3.49x49) | ARG124 (3.50x50) | 0.000 | 4.195 | -4.195 | MED |
| 30 | ARG376 | TYR386 | 0.000 | 4.173 | -4.173 | MED |
| 31 | CYS53 (1.59x59) | CYS345 | 0.000 | 4.129 | -4.129 | MED |
| 32 | LEU218 (5.72x72) | LYS263 (6.26x26) | 4.017 | 0.000 | +4.017 | MED |
| 33 | TYR326 (7.53x53) | PHE333 (8.50x50) | 0.000 | 3.945 | -3.945 | MED |
| 34 | TRP285 (6.48x48) | GLY315 (7.42x41) | 4.768 | 8.702 | -3.934 | MED |
| 35 | PRO327 (7.54x54) | PHE337 (8.54x54) | 0.000 | 3.815 | -3.815 | MED |
| 36 | GLU214 (5.68x68) | PHE264 (6.27x27) | 0.000 | 3.721 | -3.721 | MED |
| 37 | ASN318 (7.45x45) | ASN322 (7.49x49) | 4.116 | 0.474 | +3.642 | MED |
| 38 | PRO327 (7.54x54) | LYS334 (8.51x51) | 0.496 | 4.091 | -3.595 | MED |
| 39 | ARG96 (3.22x22) | ILE175 | 3.557 | 0.000 | +3.557 | MED |
| 40 | LEU222 (5.76x76) | LEU234 | 0.000 | 3.531 | -3.531 | MED |
| 41 | ASN44 (1.50x50) | ASP72 (2.50x50) | 6.230 | 2.786 | +3.444 | MED |
| 42 | TYR204 (5.58x58) | LEU274 (6.37x37) | 2.034 | 5.462 | -3.429 | MED |
| 43 | TYR204 (5.58x58) | VAL278 (6.41x41) | 1.684 | 5.107 | -3.423 | MED |
| 44 | TYR125 (3.51x51) | MET203 (5.57x57) | 4.775 | 1.368 | +3.407 | MED |
| 45 | HIS237 | SER460 | 0.000 | 3.340 | -3.340 | MED |
| 46 | ARG124 (3.50x50) | LEU274 (6.37x37) | 0.000 | 3.247 | -3.247 | MED |
| 47 | ARG166 | GLU181 (5.35x36) | 3.235 | 0.000 | +3.235 | MED |
| 48 | PRO182 (5.36x37) | SER296 (6.59x59) | 0.549 | 3.739 | -3.190 | MED |
| 49 | ARG260 | PHE429 | 0.000 | 3.178 | -3.178 | MED |
| 50 | PHE193 (5.47x47) | PHE289 (6.52x52) | 12.991 | 16.099 | -3.108 | MED |
| 51 | TRP165 (4.64x64) | GLU181 (5.35x36) | 8.358 | 5.259 | +3.099 | MED |
| 52 | ASN44 (1.50x50) | LEU73 (2.51x51) | 4.199 | 1.170 | +3.029 | MED |
| 53 | ARG124 (3.50x50) | GLU267 (6.30x30) | 0.000 | 3.022 | -3.022 | MED |
| 54 | GLN167 | GLU181 (5.35x36) | 0.964 | 3.963 | -2.999 | MED |
| 55 | HIS54 | ASN339 (8.56x56) | 1.064 | 4.053 | -2.988 | MED |
| 56 | GLY221 (5.75x75) | ARG235 | 0.000 | 2.965 | -2.965 | MED |
| 57 | ARG124 (3.50x50) | SER329 (7.56x56) | 2.951 | 0.000 | +2.951 | MED |
| 58 | ARG124 (3.50x50) | TYR204 (5.58x58) | 3.304 | 0.358 | +2.946 | MED |
| 59 | ALA104 | SER158 | 5.344 | 2.427 | +2.917 | MED |
| 60 | GLY160 | TRP165 (4.64x64) | 4.990 | 2.117 | +2.873 | MED |
| 61 | LYS219 | LYS263 (6.26x26) | 2.844 | 0.000 | +2.844 | MED |
| 62 | PHE94 | PHE98 (3.24x24) | 0.925 | 3.698 | -2.773 | MED |
| 63 | ILE236 | LEU459 | 0.000 | 2.752 | -2.752 | MED |
| 64 | PHE337 (8.54x54) | LEU341 | 2.744 | 0.000 | +2.744 | MED |
| 65 | LEU117 (3.43x43) | PHE281 (6.44x44) | 1.592 | 4.314 | -2.722 | MED |
| 66 | ARG166 | ASN179 | 8.346 | 5.682 | +2.664 | MED |
| 67 | TYR130 | ARG133 | 2.976 | 0.313 | +2.663 | MED |
| 68 | GLN167 | GLU180 | 4.228 | 6.882 | -2.655 | MED |
| 69 | PHE312 | TYR316 | 6.048 | 8.648 | -2.600 | MED |
| 70 | VAL60 | GLN140 | 3.829 | 1.252 | +2.577 | MED |
| 71 | CYS284 | ASN318 (7.45x45) | 3.590 | 1.016 | +2.573 | MED |
| 72 | ARG96 (3.22x22) | ALA169 | 0.838 | 3.391 | -2.553 | MED |
| 73 | TYR208 | LYS212 | 0.828 | 3.332 | -2.504 | MED |
| 74 | HIS237 | SER458 | 0.000 | 2.502 | -2.502 | MED |
| 75 | HIS56 | GLU332 | 0.685 | 3.174 | -2.489 | MED |
| 76 | HIS256 | ARG260 | 6.543 | 8.996 | -2.452 | MED |
| 77 | ILE119 | ALA146 | 0.000 | 2.451 | -2.451 | MED |
| 78 | SER83 | TYR316 | 3.911 | 1.465 | +2.446 | MED |
| 79 | PHE288 | MET292 | 0.288 | 2.710 | -2.422 | MED |
| 80 | ARG216 | LYS263 (6.26x26) | 2.340 | 0.000 | +2.340 | MED |
| 81 | ILE410 | THR411 | 0.055 | 2.393 | -2.339 | MED |
| 82 | SER129 | VAL210 | 0.147 | 2.455 | -2.308 | MED |
| 83 | TYR64 | ILE119 | 2.723 | 5.019 | -2.296 | MED |
| 84 | TRP285 (6.48x48) | ASN318 (7.45x45) | 5.504 | 3.241 | +2.264 | MED |
| 85 | TYR208 | LEU274 (6.37x37) | 2.228 | 0.000 | +2.228 | MED |
| 86 | ARG166 | GLN177 | 2.378 | 0.155 | +2.223 | MED |
| 87 | CYS118 | PRO196 | 1.350 | 3.569 | -2.219 | MED |
| 88 | PRO170 | GLN177 | 2.212 | 0.000 | +2.212 | MED |
| 89 | LEU218 (5.72x72) | LEU261 | 0.000 | 2.200 | -2.200 | MED |
| 90 | SER460 | GLU464 | 0.565 | 2.726 | -2.161 | LOW |
| 91 | ILE65 | TYR326 (7.53x53) | 0.025 | 2.184 | -2.159 | LOW |
| 92 | PHE39 | CYS320 | 1.544 | 3.671 | -2.127 | LOW |
| 93 | GLY43 | PRO323 | 2.383 | 4.498 | -2.115 | LOW |
| 94 | SER413 | LYS414 | 1.094 | 3.209 | -2.115 | LOW |
| 95 | GLU181 (5.35x36) | PRO182 (5.36x37) | 0.917 | 3.027 | -2.110 | LOW |
| 96 | TRP165 (4.64x64) | GLY183 | 0.000 | 2.087 | -2.087 | LOW |
| 97 | TRP92 | CYS176 | 4.728 | 6.807 | -2.079 | LOW |
| 98 | VAL340 | CYS345 | 0.000 | 2.064 | -2.064 | LOW |
| 99 | CYS284 | LEU314 | 5.649 | 7.702 | -2.053 | LOW |
| 100 | LEU459 | GLU464 | 2.874 | 4.912 | -2.038 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.19 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 44-53 | 47 (4.8), 44 (3.4) | 2 | 53 (-4.1) | 1 |
| TM2 | 61-82 | 72 (6.6), 63 (4.7), 73 (3.0) | 3 | 82 (-7.2), 62 (-6.8), 61 (-4.9) | 3 |
| TM3 | 96-125 | 114 (4.9), 117 (4.6), 125 (4.4), 96 (3.6) | 4 | 98 (-7.2), 124 (-4.9), 123 (-4.2) | 3 |
| TM4 | 165-165 | 165 (3.1) | 1 | - | 0 |
| TM5 | 181-222 | 215 (5.5), 206 (4.4), 218 (4.0), 203 (3.4), 181 (3.2) | 5 | 221 (-6.7), 204 (-4.6), 217 (-4.4), 222 (-4.4), 214 (-4.3), 182 (-3.2), 193 (-3.1) | 7 |
| TM6 | 263-296 | 263 (5.5), 267 (5.0) | 2 | 281 (-8.3), 285 (-8.3), 273 (-8.2), 275 (-4.6), 264 (-3.7), 274 (-3.4), 278 (-3.4), 296 (-3.2), 289 (-3.1) | 9 |
| TM7 | 315-329 | 327 (7.8), 319 (6.6), 326 (4.6), 322 (3.6) | 4 | 329 (-8.2), 318 (-5.7), 315 (-3.9) | 3 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 57-58 | 58 (4.7) | 1 | 57 (-6.8) | 1 |
| ICL2 | 132-132 | - | 0 | 132 (-5.5) | 1 |
| ICL3 | 223-260 | - | 0 | 238 (-9.5), 236 (-6.7), 260 (-5.5), 237 (-5.0), 223 (-4.5), 234 (-4.5) | 6 |
| ECL1 | - | - | 0 | - | 0 |
| ECL2 | 166-175 | 172 (5.0), 174 (5.0), 175 (3.6), 166 (3.2) | 4 | - | 0 |
| ECL3 | - | - | 0 | - | 0 |
| H8 | 333-339 | 333 (7.8) | 1 | 339 (-5.9), 337 (-3.8), 334 (-3.6) | 3 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
131 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 238 | p.Arg238Leu | c.713G>T | 6.84e-07 | 1 / 0 | 9.51 | 0.527 | AMBIGUOUS | 0.51 | |
| 238 | p.Arg238Trp | c.712C>T | 6.16e-06 | 9 / 0 | 9.51 | - | nan | - | rs141722973 |
| 281 | p.Phe281Leu | c.843C>A | 6.84e-07 | 1 / 0 | 8.25 | 0.999 | PATHOGENIC | 0.95 | rs1307815039 |
| 285 | p.Trp285Cys | c.855G>T | 6.84e-07 | 1 / 0 | 8.25 | 0.996 | PATHOGENIC | 0.95 | rs532108221 |
| 281 | p.Phe281Ser | c.842T>C | 6.84e-07 | 1 / 0 | 8.25 | - | nan | - | |
| 281 | p.Phe281Val | c.841T>G | 6.84e-07 | 1 / 0 | 8.25 | - | nan | - | rs916744865 |
| 281 | p.Phe281Leu | c.841T>C | 6.84e-07 | 1 / 0 | 8.25 | - | nan | - | |
| 273 | p.Thr273Met | c.818C>T | 2.05e-06 | 3 / 0 | 8.16 | 0.630 | PATHOGENIC | 0.90 | rs1218686921 |
| 329 | p.Ser329Phe | c.986C>T | 6.84e-07 | 1 / 0 | 8.16 | 0.229 | BENIGN | 0.49 | |
| 329 | p.Ser329Ala | c.985T>G | 6.57e-06 | 1 / 0 | 8.16 | - | nan | - | rs544693873 |
| 329 | p.Ser329Pro | c.985T>C | 6.84e-07 | 1 / 0 | 8.16 | - | nan | - | |
| 333 | p.Val333Ala | c.998T>C | 1.09e-05 | 6 / 0 | 7.75 | 0.992 | PATHOGENIC | 0.88 | rs781403607 |
| 62 | p.His62Arg | c.185A>G | 1.37e-06 | 2 / 0 | 6.79 | 0.895 | PATHOGENIC | 0.67 | rs1813775984 |
| 221 | p.Gly221Ser | c.661G>A | 4.10e-06 | 6 / 0 | 6.68 | 0.769 | PATHOGENIC | 0.81 | rs201098896 |
| 72 | p.Asp72Glu | c.216C>A | 5.47e-06 | 8 / 0 | 6.58 | 0.997 | PATHOGENIC | 1.00 | rs1455659706 |
| 319 | p.Ser319Ile | c.956G>T | 6.84e-07 | 1 / 0 | 6.58 | 0.976 | PATHOGENIC | 0.97 | |
| 319 | p.Ser319Gly | c.955A>G | 1.37e-06 | 2 / 0 | 6.58 | - | nan | - | |
| 319 | p.Val319Met | c.955G>A | 3.63e-06 | 2 / 0 | 6.58 | - | nan | - | |
| 72 | p.Asp72His | c.214G>C | 9.58e-06 | 12 / 1 | 6.58 | - | nan | - | rs748400751 |
| 72 | p.Asp72Asn | c.214G>A | 1.37e-06 | 2 / 0 | 6.58 | - | nan | - | rs748400751 |
| 339 | p.Asn339Lys | c.1017T>G | 6.84e-07 | 1 / 0 | 5.91 | 0.438 | AMBIGUOUS | 0.51 | rs1174794179 |
| 339 | p.Asn339Thr | c.1016A>C | 6.84e-07 | 1 / 0 | 5.91 | - | nan | - | |
| 339 | p.Cys339Ser | c.1015T>A | 1.82e-06 | 1 / 0 | 5.91 | - | nan | - | |
| 371 | p.His371Asp | c.1111C>G | 6.84e-07 | 1 / 0 | 5.86 | 0.088 | BENIGN | 0.32 | rs749700097 |
| 318 | p.Ala318Val | c.953C>T | 1.82e-06 | 1 / 0 | 5.74 | 0.986 | PATHOGENIC | 0.95 | |
| 318 | p.Ala318Thr | c.952G>A | 6.57e-06 | 1 / 0 | 5.74 | - | nan | - | rs1714236088 |
| 458 | p.Ser458Pro | c.1372T>C | 6.58e-06 | 1 / 0 | 5.62 | 0.906 | PATHOGENIC | 0.96 | rs1204162907 |
| 466 | p.Cys466Tyr | c.1397G>A | 3.69e-06 | 1 / 0 | 5.62 | 0.670 | PATHOGENIC | 0.94 | rs1804793057 |
| 399 | p.Phe399Leu | c.1195T>C | 6.84e-07 | 1 / 0 | 5.60 | 0.338 | BENIGN | 0.49 | rs1563237725 |
| 263 | p.Lys263Asn | c.789G>T | 6.84e-07 | 1 / 0 | 5.52 | 0.979 | PATHOGENIC | 0.77 | |
| 215 | p.Ser215Asn | c.644G>A | 2.33e-05 | 34 / 0 | 5.52 | 0.171 | BENIGN | 0.51 | rs749902900 |
| 260 | p.Arg260Trp | c.778A>T | 6.84e-07 | 1 / 0 | 5.46 | 0.660 | PATHOGENIC | 0.69 | |
| 237 | p.His237Arg | c.710A>G | 6.84e-07 | 1 / 0 | 5.03 | 0.971 | PATHOGENIC | 0.80 | rs1262421772 |
| 459 | p.Ala459Val | c.1376C>T | 4.20e-06 | 1 / 0 | 5.03 | 0.094 | BENIGN | 0.73 | rs1231983964 |
| 459 | p.Ala459Glu | c.1376C>A | 1.26e-05 | 3 / 0 | 5.03 | - | nan | - | rs1231983964 |
| 459 | p.Leu459Arg | c.1376T>G | 7.07e-07 | 1 / 0 | 5.03 | - | nan | - | |
| 459 | p.Leu459Val | c.1375C>G | 7.06e-07 | 1 / 0 | 5.03 | - | nan | - | |
| 174 | p.Thr174Ile | c.521C>T | 6.84e-07 | 1 / 0 | 5.02 | 0.482 | AMBIGUOUS | 0.40 | rs1813726916 |
| 172 | p.Asp172Asn | c.514G>A | 6.57e-06 | 1 / 0 | 5.02 | 0.147 | BENIGN | 0.69 | rs1250025758 |
| 174 | p.Thr174Pro | c.520A>C | 6.84e-07 | 1 / 0 | 5.02 | - | nan | - | |
| 267 | p.Glu267Gln | c.799G>C | 2.74e-06 | 4 / 0 | 4.99 | 0.677 | PATHOGENIC | 0.87 | rs1393618610 |
| 114 | p.Ile114Asn | c.341T>A | 6.57e-06 | 1 / 0 | 4.92 | 0.982 | PATHOGENIC | 1.00 | rs748982353 |
| 114 | p.Ile114Thr | c.341T>C | 2.05e-06 | 3 / 0 | 4.92 | - | nan | - | rs748982353 |
| 114 | p.Ile114Val | c.340A>G | 2.05e-06 | 3 / 0 | 4.92 | - | nan | - | rs1256300248 |
| 114 | p.Ile114Phe | c.340A>T | 6.57e-06 | 1 / 0 | 4.92 | - | nan | - | rs1256300248 |
| 124 | p.Arg124His | c.371G>A | 1.03e-05 | 15 / 0 | 4.91 | 0.970 | PATHOGENIC | 0.99 | |
| 61 | p.Thr61Arg | c.182C>G | 6.84e-07 | 1 / 0 | 4.91 | 0.931 | PATHOGENIC | 0.81 | |
| 124 | p.Arg124Cys | c.370C>T | 1.09e-05 | 16 / 0 | 4.91 | - | nan | - | rs747122943 |
| 124 | p.Arg124Ser | c.370C>A | 3.42e-06 | 5 / 0 | 4.91 | - | nan | - | rs747122943 |
| 124 | p.Arg124Gly | c.370C>G | 4.10e-06 | 6 / 0 | 4.91 | - | nan | - | rs747122943 |
| 47 | p.Val47Ala | c.140T>C | 6.16e-06 | 9 / 0 | 4.84 | 0.984 | PATHOGENIC | 0.97 | rs779890003 |
| 47 | p.Val47Gly | c.140T>G | 6.84e-07 | 1 / 0 | 4.84 | - | nan | - | |
| 47 | p.Val47Met | c.139G>A | 1.31e-05 | 2 / 0 | 4.84 | - | nan | - | rs1243477642 |
| 63 | p.Tyr63His | c.187T>C | 1.37e-06 | 2 / 0 | 4.73 | 0.490 | AMBIGUOUS | 0.71 | |
| 58 | p.His58Arg | c.173A>G | 6.84e-07 | 1 / 0 | 4.73 | 0.086 | BENIGN | 0.68 | |
| 63 | p.Tyr63Asn | c.187T>A | 6.84e-07 | 1 / 0 | 4.73 | - | nan | - | |
| 58 | p.His58Tyr | c.172C>T | 6.84e-07 | 1 / 0 | 4.73 | - | nan | - | |
| 204 | p.Tyr204His | c.610T>C | 6.84e-07 | 1 / 0 | 4.61 | 0.994 | PATHOGENIC | 0.98 | rs1293034019 |
| 275 | p.Gly275Val | c.824G>T | 6.84e-07 | 1 / 0 | 4.61 | 0.950 | PATHOGENIC | 0.74 | |
| 275 | p.Gly275Asp | c.824G>A | 2.05e-06 | 3 / 0 | 4.61 | - | nan | - | |
| 275 | p.Gly275Ser | c.823G>A | 4.72e-05 | 69 / 0 | 4.61 | - | nan | - | rs201224020 |
| 117 | p.Leu117Arg | c.350T>G | 6.84e-07 | 1 / 0 | 4.58 | 0.991 | PATHOGENIC | 1.00 | rs1813753776 |
| 326 | p.Tyr326Cys | c.977A>G | 2.74e-06 | 4 / 0 | 4.58 | 0.990 | PATHOGENIC | 0.98 | |
| 326 | p.Tyr326His | c.976T>C | 6.57e-06 | 1 / 0 | 4.58 | - | nan | - | rs1326198666 |
| 326 | p.Tyr326Asn | c.976T>A | 6.84e-07 | 1 / 0 | 4.58 | - | nan | - | rs1326198666 |
| 326 | p.Glu326Lys | c.976G>A | 1.82e-06 | 1 / 0 | 4.58 | - | nan | - | |
| 326 | p.Glu326Gln | c.976G>C | 2.00e-05 | 11 / 0 | 4.58 | - | nan | - | rs1041635161 |
| 234 | p.Leu234Phe | c.700C>T | 2.74e-06 | 4 / 0 | 4.48 | 0.888 | PATHOGENIC | 0.79 | |
| 222 | p.Leu222Pro | c.665T>C | 2.05e-06 | 3 / 0 | 4.44 | 0.816 | PATHOGENIC | 0.45 | rs1406968822 |
| 217 | p.Gly217Ala | c.650G>C | 4.17e-05 | 61 / 0 | 4.44 | 0.181 | BENIGN | 0.39 | rs760453930 |
| 222 | p.Leu222Phe | c.664C>T | 6.84e-07 | 1 / 0 | 4.44 | - | nan | - | rs1324162537 |
| 222 | p.Leu222Ile | c.664C>A | 6.84e-07 | 1 / 0 | 4.44 | - | nan | - | rs1324162537 |
| 217 | p.Gly217Val | c.650G>T | 6.84e-07 | 1 / 0 | 4.44 | - | nan | - | |
| 217 | p.Gly217Arg | c.649G>C | 1.37e-06 | 2 / 0 | 4.44 | - | nan | - | rs150544480 |
| 217 | p.Gly217Ser | c.649G>A | 8.21e-06 | 12 / 0 | 4.44 | - | nan | - | rs150544480 |
| 125 | p.Tyr125His | c.373T>C | 6.84e-07 | 1 / 0 | 4.38 | 0.927 | PATHOGENIC | 0.97 | |
| 206 | p.Arg206Gly | c.616C>G | 1.37e-06 | 2 / 0 | 4.38 | 0.643 | PATHOGENIC | 0.82 | rs1285479324 |
| 214 | p.Glu214Gly | c.641A>G | 6.84e-07 | 1 / 0 | 4.33 | 0.695 | PATHOGENIC | 0.47 | |
| 214 | p.Glu214Gln | c.640G>C | 6.84e-07 | 1 / 0 | 4.33 | - | nan | - | |
| 123 | p.Asp123Asn | c.367G>A | 4.79e-06 | 7 / 0 | 4.19 | 0.990 | PATHOGENIC | 0.96 | rs61757010 |
| 123 | p.Asp123Tyr | c.367G>T | 1.09e-05 | 16 / 0 | 4.19 | - | nan | - | rs61757010 |
| 386 | p.Tyr386Cys | c.1157A>G | 6.84e-07 | 1 / 0 | 4.17 | 0.176 | BENIGN | 0.64 | rs759652152 |
| 376 | p.Arg376His | c.1127G>A | 3.22e-05 | 47 / 0 | 4.17 | 0.112 | BENIGN | 0.61 | rs140512348 |
| 386 | p.Tyr386His | c.1156T>C | 5.47e-06 | 8 / 0 | 4.17 | - | nan | - | rs1806052198 |
| 376 | p.Arg376Pro | c.1127G>C | 6.57e-06 | 1 / 0 | 4.17 | - | nan | - | rs140512348 |
| 376 | p.Arg376Leu | c.1127G>T | 5.47e-06 | 8 / 0 | 4.17 | - | nan | - | rs140512348 |
| 376 | p.Arg376Cys | c.1126C>T | 3.28e-05 | 44 / 2 | 4.17 | - | nan | - | rs1496121 |
| 376 | p.Arg376Ser | c.1126C>A | 6.84e-07 | 1 / 0 | 4.17 | - | nan | - | rs1496121 |
| 376 | p.Arg376Gly | c.1126C>G | 6.84e-07 | 1 / 0 | 4.17 | - | nan | - | rs1496121 |
| 53 | p.Cys53Arg | c.157T>C | 2.05e-06 | 3 / 0 | 4.13 | 0.645 | PATHOGENIC | 0.44 | |
| 345 | p.Cys345Arg | c.1033T>C | 2.74e-06 | 4 / 0 | 4.13 | 0.333 | BENIGN | 0.77 | |
| 218 | p.Leu218Val | c.652C>G | 5.47e-06 | 8 / 0 | 4.02 | 0.516 | AMBIGUOUS | 0.74 | rs766542151 |
| 315 | p.Gly315Arg | c.943G>A | 1.30e-05 | 19 / 0 | 3.93 | 0.998 | PATHOGENIC | 0.96 | rs756970856 |
| 315 | p.His315Arg | c.944A>G | 5.45e-06 | 3 / 0 | 3.93 | - | nan | - | |
| 315 | p.His315Asp | c.943C>G | 1.82e-06 | 1 / 0 | 3.93 | - | nan | - | |
| 337 | p.Asp337Ala | c.1010A>C | 1.82e-06 | 1 / 0 | 3.81 | 0.985 | PATHOGENIC | 0.94 | |
| 337 | p.Asp337His | c.1009G>C | 5.45e-06 | 3 / 0 | 3.81 | - | nan | - | rs1563246051 |
| 264 | p.Phe264Leu | c.792C>G | 6.84e-07 | 1 / 0 | 3.72 | 0.998 | PATHOGENIC | 0.82 | |
| 264 | p.Phe264Leu | c.790T>C | 6.84e-07 | 1 / 0 | 3.72 | - | nan | - | |
| 322 | p.Asn322Lys | c.966C>A | 2.05e-06 | 3 / 0 | 3.64 | 0.998 | PATHOGENIC | 0.98 | rs1315965898 |
| 322 | p.Asn322Ser | c.965A>G | 1.09e-05 | 16 / 0 | 3.64 | - | nan | - | rs1458563910 |
| 334 | p.Lys334Thr | c.1001A>C | 6.57e-06 | 1 / 0 | 3.60 | 0.801 | PATHOGENIC | 0.75 | rs1313869976 |
| 334 | p.Ser334Pro | c.1000T>C | 1.32e-05 | 2 / 0 | 3.60 | - | nan | - | rs988381380 |
| 96 | p.Arg96Lys | c.287G>A | 6.57e-06 | 1 / 0 | 3.56 | 0.204 | BENIGN | 0.58 | rs1813763764 |
| 175 | p.Ile175Met | c.525C>G | 6.84e-06 | 10 / 0 | 3.56 | 0.131 | BENIGN | 0.44 | rs756487113 |
| 175 | p.Ile175Asn | c.524T>A | 1.37e-06 | 2 / 0 | 3.56 | - | nan | - | rs1347816678 |
| 175 | p.Ile175Val | c.523A>G | 1.37e-06 | 2 / 0 | 3.56 | - | nan | - | |
| 203 | p.Met203Arg | c.608T>G | 1.37e-06 | 2 / 0 | 3.41 | 0.960 | PATHOGENIC | 0.66 | rs1291020451 |
| 203 | p.Met203Leu | c.607A>C | 6.84e-07 | 1 / 0 | 3.41 | - | nan | - | rs770251050 |
| 203 | p.Met203Val | c.607A>G | 6.84e-07 | 1 / 0 | 3.41 | - | nan | - | |
| 460 | p.Ser460Ile | c.1379G>T | 7.08e-07 | 1 / 0 | 3.34 | 0.473 | AMBIGUOUS | 0.75 | rs747894155 |
| 460 | p.Ser460Thr | c.1379G>C | 7.08e-07 | 1 / 0 | 3.34 | - | nan | - | |
| 460 | p.Ser460Asn | c.1379G>A | 1.42e-06 | 2 / 0 | 3.34 | - | nan | - | rs747894155 |
| 181 | p.Glu181Asp | c.543G>T | 6.84e-07 | 1 / 0 | 3.23 | 0.124 | BENIGN | 0.66 | |
| 166 | p.Arg166Lys | c.497G>A | 2.82e-03 | 4110 / 7 | 3.23 | 0.093 | BENIGN | 0.63 | rs56233953 |
| 181 | p.Glu181Lys | c.541G>A | 2.05e-06 | 3 / 0 | 3.23 | - | nan | - | |
| 166 | p.Arg166Gly | c.496A>G | 6.84e-07 | 1 / 0 | 3.23 | - | nan | - | rs1314932778 |
| 296 | p.Glu296Lys | c.886G>A | 9.09e-06 | 5 / 0 | 3.19 | 0.936 | PATHOGENIC | 0.49 | rs776089126 |
| 182 | p.Pro182Ser | c.544C>T | 2.05e-06 | 3 / 0 | 3.19 | 0.338 | BENIGN | 0.51 | rs551511934 |
| 429 | p.Val429Ile | c.1285G>A | 4.24e-05 | 9 / 0 | 3.18 | 0.249 | BENIGN | 0.69 | rs554972791 |
| 429 | p.Val429Phe | c.1285G>T | 9.43e-06 | 2 / 0 | 3.18 | - | nan | - | |
| 429 | p.Arg429Gly | c.1285A>G | 6.86e-07 | 1 / 0 | 3.18 | - | nan | - | rs765906061 |
| 429 | p.Phe429Leu | c.1285T>C | 6.84e-07 | 1 / 0 | 3.18 | - | nan | - | |
| 289 | p.Phe289Ser | c.866T>C | 3.42e-06 | 5 / 0 | 3.11 | 0.990 | PATHOGENIC | 0.96 | rs772571115 |
| 289 | p.Phe289Val | c.865T>G | 6.84e-07 | 1 / 0 | 3.11 | - | nan | - | |
| 165 | p.Trp165Cys | c.495G>C | 6.84e-07 | 1 / 0 | 3.10 | 0.996 | PATHOGENIC | 0.90 | rs997765683 |
| 165 | p.Trp165Gly | c.493T>G | 6.84e-07 | 1 / 0 | 3.10 | - | nan | - | rs1813730823 |
| 73 | p.Leu73Pro | c.218T>C | 6.84e-07 | 1 / 0 | 3.03 | 0.997 | PATHOGENIC | 0.89 | rs1177102605 |
| 73 | p.Leu73His | c.218T>A | 4.10e-06 | 6 / 0 | 3.03 | - | nan | - | rs1177102605 |
| 73 | p.Leu73Phe | c.217C>T | 2.74e-06 | 4 / 0 | 3.03 | - | nan | - | rs781501725 |
| 73 | p.Leu73Ile | c.217C>A | 6.57e-06 | 1 / 0 | 3.03 | - | nan | - | rs781501725 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.19, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 238 | ARG | 461 | GLU | 0.000 | 9.514 | -9.514 | 9.514 |
| 281 | PHE | 285 | TRP | 2.261 | 10.513 | -8.252 | 8.252 |
| 273 | THR | 329 | SER | 0.000 | 8.163 | -8.163 | 8.163 |
| 327 | PRO | 333 | PHE | 8.483 | 0.731 | 7.753 | 7.753 |
| 82 | PHE | 98 | PHE | 0.000 | 7.245 | -7.245 | 7.245 |
| 57 | LEU | 62 | HIS | 8.418 | 15.208 | -6.791 | 6.791 |
| 221 | GLY | 236 | ILE | 0.000 | 6.684 | -6.684 | 6.684 |
| 72 | ASP | 319 | SER | 10.457 | 3.872 | 6.584 | 6.584 |
| 339 | ASN | 344 | GLN | 0.000 | 5.911 | -5.911 | 5.911 |
| 371 | HIS | 372 | LYS | 5.862 | 0.000 | 5.862 | 5.862 |
| 281 | PHE | 318 | ASN | 0.649 | 6.389 | -5.740 | 5.740 |
| 458 | SER | 466 | VAL | 4.085 | 9.700 | -5.615 | 5.615 |
| 385 | PHE | 399 | PHE | 0.000 | 5.604 | -5.604 | 5.604 |
| 215 | SER | 263 | LYS | 5.521 | 0.000 | 5.521 | 5.521 |
| 132 | LEU | 260 | ARG | 0.000 | 5.457 | -5.457 | 5.457 |
| 237 | HIS | 459 | LEU | 0.000 | 5.033 | -5.033 | 5.033 |
| 172 | ASP | 174 | THR | 5.577 | 0.561 | 5.015 | 5.015 |
| 215 | SER | 267 | GLU | 4.993 | 0.000 | 4.993 | 4.993 |
| 114 | ILE | 285 | TRP | 4.923 | 0.000 | 4.923 | 4.923 |
| 61 | THR | 124 | ARG | 0.000 | 4.907 | -4.907 | 4.907 |
| 47 | VAL | 333 | PHE | 4.839 | 0.000 | 4.839 | 4.839 |
| 58 | HIS | 63 | TYR | 4.727 | 0.000 | 4.727 | 4.727 |
| 204 | TYR | 275 | GLY | 0.000 | 4.610 | -4.610 | 4.610 |
| 117 | LEU | 326 | TYR | 4.579 | 0.000 | 4.579 | 4.579 |
| 223 | LYS | 234 | LEU | 0.000 | 4.479 | -4.479 | 4.479 |
| 217 | GLY | 222 | LEU | 0.000 | 4.437 | -4.437 | 4.437 |
| 125 | TYR | 206 | ARG | 6.879 | 2.501 | 4.378 | 4.378 |
| 214 | GLU | 223 | LYS | 0.000 | 4.328 | -4.328 | 4.328 |
| 123 | ASP | 124 | ARG | 0.000 | 4.195 | -4.195 | 4.195 |
| 376 | ARG | 386 | TYR | 0.000 | 4.173 | -4.173 | 4.173 |
| 53 | CYS | 345 | CYS | 0.000 | 4.129 | -4.129 | 4.129 |
| 218 | LEU | 263 | LYS | 4.017 | 0.000 | 4.017 | 4.017 |
| 326 | TYR | 333 | PHE | 0.000 | 3.945 | -3.945 | 3.945 |
| 285 | TRP | 315 | GLY | 4.768 | 8.702 | -3.934 | 3.934 |
| 327 | PRO | 337 | PHE | 0.000 | 3.815 | -3.815 | 3.815 |
| 214 | GLU | 264 | PHE | 0.000 | 3.721 | -3.721 | 3.721 |
| 318 | ASN | 322 | ASN | 4.116 | 0.474 | 3.642 | 3.642 |
| 327 | PRO | 334 | LYS | 0.496 | 4.091 | -3.595 | 3.595 |
| 96 | ARG | 175 | ILE | 3.557 | 0.000 | 3.557 | 3.557 |
| 222 | LEU | 234 | LEU | 0.000 | 3.531 | -3.531 | 3.531 |
| 44 | ASN | 72 | ASP | 6.230 | 2.786 | 3.444 | 3.444 |
| 204 | TYR | 274 | LEU | 2.034 | 5.462 | -3.429 | 3.429 |
| 204 | TYR | 278 | VAL | 1.684 | 5.107 | -3.423 | 3.423 |
| 125 | TYR | 203 | MET | 4.775 | 1.368 | 3.407 | 3.407 |
| 237 | HIS | 460 | SER | 0.000 | 3.340 | -3.340 | 3.340 |
| 124 | ARG | 274 | LEU | 0.000 | 3.247 | -3.247 | 3.247 |
| 166 | ARG | 181 | GLU | 3.235 | 0.000 | 3.235 | 3.235 |
| 182 | PRO | 296 | SER | 0.549 | 3.739 | -3.190 | 3.190 |
| 260 | ARG | 429 | PHE | 0.000 | 3.178 | -3.178 | 3.178 |
| 193 | PHE | 289 | PHE | 12.991 | 16.099 | -3.108 | 3.108 |
| 165 | TRP | 181 | GLU | 8.358 | 5.259 | 3.099 | 3.099 |
| 44 | ASN | 73 | LEU | 4.199 | 1.170 | 3.029 | 3.029 |
| 124 | ARG | 267 | GLU | 0.000 | 3.022 | -3.022 | 3.022 |
| 167 | GLN | 181 | GLU | 0.964 | 3.963 | -2.999 | 2.999 |
| 54 | HIS | 339 | ASN | 1.064 | 4.053 | -2.988 | 2.988 |
| 221 | GLY | 235 | ARG | 0.000 | 2.965 | -2.965 | 2.965 |
| 124 | ARG | 329 | SER | 2.951 | 0.000 | 2.951 | 2.951 |
| 124 | ARG | 204 | TYR | 3.304 | 0.358 | 2.946 | 2.946 |
| 104 | ALA | 158 | SER | 5.344 | 2.427 | 2.917 | 2.917 |
| 160 | GLY | 165 | TRP | 4.990 | 2.117 | 2.873 | 2.873 |
| 219 | LYS | 263 | LYS | 2.844 | 0.000 | 2.844 | 2.844 |
| 94 | PHE | 98 | PHE | 0.925 | 3.698 | -2.773 | 2.773 |
| 236 | ILE | 459 | LEU | 0.000 | 2.752 | -2.752 | 2.752 |
| 337 | PHE | 341 | LEU | 2.744 | 0.000 | 2.744 | 2.744 |
| 117 | LEU | 281 | PHE | 1.592 | 4.314 | -2.722 | 2.722 |
| 166 | ARG | 179 | ASN | 8.346 | 5.682 | 2.664 | 2.664 |
| 130 | TYR | 133 | ARG | 2.976 | 0.313 | 2.663 | 2.663 |
| 167 | GLN | 180 | GLU | 4.228 | 6.882 | -2.655 | 2.655 |
| 312 | PHE | 316 | TYR | 6.048 | 8.648 | -2.600 | 2.600 |
| 60 | VAL | 140 | GLN | 3.829 | 1.252 | 2.577 | 2.577 |
| 284 | CYS | 318 | ASN | 3.590 | 1.016 | 2.573 | 2.573 |
| 96 | ARG | 169 | ALA | 0.838 | 3.391 | -2.553 | 2.553 |
| 208 | TYR | 212 | LYS | 0.828 | 3.332 | -2.504 | 2.504 |
| 237 | HIS | 458 | SER | 0.000 | 2.502 | -2.502 | 2.502 |
| 56 | HIS | 332 | GLU | 0.685 | 3.174 | -2.489 | 2.489 |
| 256 | HIS | 260 | ARG | 6.543 | 8.996 | -2.452 | 2.452 |
| 119 | ILE | 146 | ALA | 0.000 | 2.451 | -2.451 | 2.451 |
| 83 | SER | 316 | TYR | 3.911 | 1.465 | 2.446 | 2.446 |
| 288 | PHE | 292 | MET | 0.288 | 2.710 | -2.422 | 2.422 |
| 216 | ARG | 263 | LYS | 2.340 | 0.000 | 2.340 | 2.340 |
| 410 | ILE | 411 | THR | 0.055 | 2.393 | -2.339 | 2.339 |
| 129 | SER | 210 | VAL | 0.147 | 2.455 | -2.308 | 2.308 |
| 64 | TYR | 119 | ILE | 2.723 | 5.019 | -2.296 | 2.296 |
| 285 | TRP | 318 | ASN | 5.504 | 3.241 | 2.264 | 2.264 |
| 208 | TYR | 274 | LEU | 2.228 | 0.000 | 2.228 | 2.228 |
| 166 | ARG | 177 | GLN | 2.378 | 0.155 | 2.223 | 2.223 |
| 118 | CYS | 196 | PRO | 1.350 | 3.569 | -2.219 | 2.219 |
| 170 | PRO | 177 | GLN | 2.212 | 0.000 | 2.212 | 2.212 |
| 218 | LEU | 261 | LEU | 0.000 | 2.200 | -2.200 | 2.200 |
| 460 | SER | 464 | GLU | 0.565 | 2.726 | -2.161 | 2.161 |
| 65 | ILE | 326 | TYR | 0.025 | 2.184 | -2.159 | 2.159 |
| 39 | PHE | 320 | CYS | 1.544 | 3.671 | -2.127 | 2.127 |
| 43 | GLY | 323 | PRO | 2.383 | 4.498 | -2.115 | 2.115 |
| 413 | SER | 414 | LYS | 1.094 | 3.209 | -2.115 | 2.115 |
| 181 | GLU | 182 | PRO | 0.917 | 3.027 | -2.110 | 2.110 |
| 165 | TRP | 183 | GLY | 0.000 | 2.087 | -2.087 | 2.087 |
| 92 | TRP | 176 | CYS | 4.728 | 6.807 | -2.079 | 2.079 |
| 340 | VAL | 345 | CYS | 0.000 | 2.064 | -2.064 | 2.064 |
| 284 | CYS | 314 | LEU | 5.649 | 7.702 | -2.053 | 2.053 |
| 459 | LEU | 464 | GLU | 2.874 | 4.912 | -2.038 | 2.038 |
| 96 | ARG | 171 | GLU | 0.000 | 2.017 | -2.017 | 2.017 |
| 200 | ILE | 281 | PHE | 2.017 | 0.000 | 2.017 | 2.017 |
| 133 | ARG | 427 | LYS | 0.000 | 2.015 | -2.015 | 2.015 |
| 374 | MET | 376 | ARG | 1.996 | 0.000 | 1.996 | 1.996 |
| 72 | ASP | 322 | ASN | 4.716 | 2.759 | 1.957 | 1.957 |
| 277 | VAL | 325 | ILE | 0.819 | 2.750 | -1.932 | 1.932 |
| 132 | LEU | 256 | HIS | 0.000 | 1.894 | -1.894 | 1.894 |
| 44 | ASN | 69 | ALA | 5.923 | 4.041 | 1.882 | 1.882 |
| 396 | GLU | 398 | LYS | 3.466 | 1.588 | 1.878 | 1.878 |
| 100 | ASN | 166 | ARG | 4.708 | 6.586 | -1.878 | 1.878 |
| 224 | THR | 232 | VAL | 0.000 | 1.873 | -1.873 | 1.873 |
| 114 | ILE | 281 | PHE | 1.500 | 3.369 | -1.868 | 1.868 |
| 118 | CYS | 199 | ILE | 1.990 | 0.123 | 1.867 | 1.867 |
| 288 | PHE | 289 | PHE | 2.356 | 0.495 | 1.860 | 1.860 |
| 189 | ALA | 289 | PHE | 2.331 | 0.489 | 1.842 | 1.842 |
| 120 | ILE | 274 | LEU | 0.000 | 1.828 | -1.828 | 1.828 |
| 71 | ALA | 113 | SER | 0.925 | 2.741 | -1.816 | 1.816 |
| 165 | TRP | 184 | TYR | 1.150 | 2.956 | -1.806 | 1.806 |
| 208 | TYR | 271 | ALA | 1.793 | 0.000 | 1.793 | 1.793 |
| 221 | GLY | 234 | LEU | 0.000 | 1.772 | -1.772 | 1.772 |
| 51 | VAL | 58 | HIS | 0.000 | 1.709 | -1.709 | 1.709 |
| 47 | VAL | 337 | PHE | 0.735 | 2.442 | -1.707 | 1.707 |
| 124 | ARG | 326 | TYR | 1.706 | 0.000 | 1.706 | 1.706 |
| 212 | LYS | 267 | GLU | 1.699 | 0.000 | 1.699 | 1.699 |
| 197 | LEU | 281 | PHE | 1.685 | 0.000 | 1.685 | 1.685 |
| 204 | TYR | 277 | VAL | 1.681 | 0.000 | 1.681 | 1.681 |
| 120 | ILE | 124 | ARG | 1.870 | 0.196 | 1.674 | 1.674 |
| 193 | PHE | 285 | TRP | 3.384 | 1.711 | 1.673 | 1.673 |
| 47 | VAL | 326 | TYR | 0.000 | 1.645 | -1.645 | 1.645 |
| 117 | LEU | 322 | ASN | 1.641 | 0.000 | 1.641 | 1.641 |
| 63 | TYR | 140 | GLN | 3.141 | 1.500 | 1.641 | 1.641 |
| 161 | PRO | 184 | TYR | 6.917 | 8.548 | -1.630 | 1.630 |
| 68 | LEU | 117 | LEU | 2.657 | 1.037 | 1.619 | 1.619 |
| 165 | TRP | 187 | PHE | 0.119 | 1.738 | -1.619 | 1.619 |
| 222 | LEU | 233 | THR | 0.000 | 1.612 | -1.612 | 1.612 |
| 157 | ILE | 184 | TYR | 3.244 | 1.639 | 1.605 | 1.605 |
| 317 | LEU | 321 | ILE | 1.599 | 0.000 | 1.599 | 1.599 |
| 58 | HIS | 140 | GLN | 1.877 | 0.282 | 1.596 | 1.596 |
| 161 | PRO | 166 | ARG | 2.129 | 0.539 | 1.591 | 1.591 |
| 211 | ALA | 264 | PHE | 0.000 | 1.590 | -1.590 | 1.590 |
| 237 | HIS | 461 | GLU | 0.000 | 1.588 | -1.588 | 1.588 |
| 388 | ILE | 396 | GLU | 0.000 | 1.587 | -1.587 | 1.587 |
| 342 | ARG | 344 | GLN | 0.000 | 1.574 | -1.574 | 1.574 |
| 92 | TRP | 98 | PHE | 1.679 | 3.239 | -1.560 | 1.560 |
| 224 | THR | 233 | THR | 0.000 | 1.553 | -1.553 | 1.553 |
| 180 | GLU | 296 | SER | 1.257 | 2.793 | -1.537 | 1.537 |
| 96 | ARG | 172 | ASP | 2.528 | 0.993 | 1.535 | 1.535 |
| 180 | GLU | 292 | MET | 1.528 | 0.000 | 1.528 | 1.528 |
| 74 | LEU | 78 | THR | 1.499 | 0.000 | 1.499 | 1.499 |
| 62 | HIS | 333 | PHE | 0.180 | 1.677 | -1.497 | 1.497 |
| 47 | VAL | 327 | PRO | 1.494 | 0.000 | 1.494 | 1.494 |
| 108 | LEU | 155 | LEU | 1.882 | 3.360 | -1.478 | 1.478 |
| 167 | GLN | 178 | ILE | 1.463 | 0.000 | 1.463 | 1.463 |
| 96 | ARG | 173 | GLU | 3.742 | 2.295 | 1.447 | 1.447 |
| 313 | TRP | 316 | TYR | 2.407 | 1.003 | 1.404 | 1.404 |
| 257 | PHE | 261 | LEU | 3.183 | 4.580 | -1.397 | 1.397 |
| 56 | HIS | 57 | LEU | 4.504 | 5.899 | -1.395 | 1.395 |
| 96 | ARG | 100 | ASN | 1.634 | 0.240 | 1.394 | 1.394 |
| 288 | PHE | 312 | PHE | 1.826 | 3.205 | -1.379 | 1.379 |
| 375 | VAL | 387 | ARG | 0.000 | 1.378 | -1.378 | 1.378 |
| 120 | ILE | 326 | TYR | 1.371 | 0.000 | 1.371 | 1.371 |
| 79 | VAL | 102 | TRP | 3.533 | 4.904 | -1.371 | 1.371 |
| 225 | ASP | 232 | VAL | 0.000 | 1.368 | -1.368 | 1.368 |
| 411 | THR | 412 | VAL | 0.613 | 1.976 | -1.363 | 1.363 |
| 200 | ILE | 278 | VAL | 0.007 | 1.367 | -1.360 | 1.360 |
| 236 | ILE | 257 | PHE | 0.000 | 1.316 | -1.316 | 1.316 |
| 114 | ILE | 192 | SER | 3.146 | 4.461 | -1.314 | 1.314 |
| 284 | CYS | 315 | GLY | 1.008 | 2.310 | -1.301 | 1.301 |
| 458 | SER | 465 | GLU | 0.306 | 1.605 | -1.300 | 1.300 |
| 51 | VAL | 333 | PHE | 1.737 | 0.453 | 1.283 | 1.283 |
| 127 | GLY | 267 | GLU | 0.000 | 1.257 | -1.257 | 1.257 |
| 202 | VAL | 206 | ARG | 1.302 | 0.048 | 1.254 | 1.254 |
| 49 | LEU | 340 | VAL | 0.556 | 1.806 | -1.249 | 1.249 |
| 415 | ASP | 416 | GLN | 1.310 | 0.071 | 1.240 | 1.240 |
| 54 | HIS | 336 | ALA | 5.974 | 7.210 | -1.236 | 1.236 |
| 189 | ALA | 194 | TYR | 4.621 | 5.847 | -1.225 | 1.225 |
| 225 | ASP | 429 | PHE | 0.000 | 1.208 | -1.208 | 1.208 |
| 227 | SER | 228 | ASP | 1.206 | 0.000 | 1.206 | 1.206 |
| 167 | GLN | 177 | GLN | 1.186 | 0.000 | 1.186 | 1.186 |
| 46 | LEU | 344 | GLN | 1.171 | 0.000 | 1.171 | 1.171 |
| 389 | SER | 391 | THR | 1.169 | 0.000 | 1.169 | 1.169 |
| 277 | VAL | 326 | TYR | 1.890 | 0.721 | 1.169 | 1.169 |
| 239 | LYS | 240 | ASN | 1.167 | 0.000 | 1.167 | 1.167 |
| 92 | TRP | 99 | CYS | 7.475 | 6.311 | 1.164 | 1.164 |
| 305 | GLU | 309 | LYS | 2.950 | 4.107 | -1.157 | 1.157 |
| 104 | ALA | 162 | LEU | 1.152 | 0.000 | 1.152 | 1.152 |
| 96 | ARG | 170 | PRO | 6.341 | 5.194 | 1.147 | 1.147 |
| 384 | THR | 386 | TYR | 0.000 | 1.140 | -1.140 | 1.140 |
| 7 | ASN | 8 | ALA | 0.000 | 1.139 | -1.139 | 1.139 |
| 192 | SER | 289 | PHE | 2.550 | 1.412 | 1.138 | 1.138 |
| 193 | PHE | 194 | TYR | 2.201 | 1.068 | 1.133 | 1.133 |
| 361 | HIS | 362 | PRO | 1.591 | 0.458 | 1.133 | 1.133 |
| 74 | LEU | 109 | CYS | 2.097 | 0.978 | 1.119 | 1.119 |
| 172 | ASP | 175 | ILE | 2.572 | 1.454 | 1.118 | 1.118 |
| 277 | VAL | 322 | ASN | 0.000 | 1.111 | -1.111 | 1.111 |
| 64 | TYR | 123 | ASP | 4.491 | 3.386 | 1.105 | 1.105 |
| 254 | LYS | 258 | SER | 0.000 | 1.105 | -1.105 | 1.105 |
| 41 | VAL | 76 | THR | 4.626 | 3.525 | 1.100 | 1.100 |
| 44 | ASN | 323 | PRO | 4.644 | 3.555 | 1.088 | 1.088 |
| 60 | VAL | 64 | TYR | 3.252 | 2.164 | 1.088 | 1.088 |
| 128 | VAL | 264 | PHE | 0.000 | 1.076 | -1.076 | 1.076 |
| 112 | ALA | 150 | VAL | 0.508 | 1.579 | -1.071 | 1.071 |
| 124 | ARG | 270 | ALA | 0.000 | 1.067 | -1.067 | 1.067 |
| 292 | MET | 296 | SER | 1.066 | 0.000 | 1.066 | 1.066 |
| 215 | SER | 268 | LYS | 0.000 | 1.050 | -1.050 | 1.050 |
| 193 | PHE | 281 | PHE | 1.507 | 0.457 | 1.050 | 1.050 |
| 44 | ASN | 319 | SER | 1.531 | 2.564 | -1.033 | 1.033 |
| 182 | PRO | 297 | PHE | 3.648 | 2.615 | 1.033 | 1.033 |
| 100 | ASN | 162 | LEU | 1.039 | 0.009 | 1.029 | 1.029 |
| 124 | ARG | 271 | ALA | 0.000 | 1.028 | -1.028 | 1.028 |
| 330 | SER | 333 | PHE | 1.152 | 2.163 | -1.011 | 1.011 |
| 197 | LEU | 282 | VAL | 0.586 | 1.594 | -1.008 | 1.008 |
| 460 | SER | 466 | VAL | 1.834 | 0.831 | 1.003 | 1.003 |
| 29 | LEU | 87 | GLU | 0.443 | 1.444 | -1.001 | 1.001 |
| 128 | VAL | 267 | GLU | 0.000 | 0.998 | -0.998 | 0.998 |
| 118 | CYS | 200 | ILE | 2.547 | 3.541 | -0.994 | 0.994 |
| 60 | VAL | 138 | VAL | 1.671 | 2.653 | -0.982 | 0.982 |
| 444 | ASP | 445 | LYS | 0.000 | 0.973 | -0.973 | 0.973 |
| 225 | ASP | 428 | SER | 0.000 | 0.971 | -0.971 | 0.971 |
| 285 | TRP | 288 | PHE | 0.000 | 0.970 | -0.970 | 0.970 |
| 50 | SER | 340 | VAL | 2.279 | 1.312 | 0.967 | 0.967 |
| 67 | ASN | 151 | TRP | 4.356 | 3.393 | 0.962 | 0.962 |
| 76 | THR | 319 | SER | 0.228 | 1.177 | -0.949 | 0.949 |
| 343 | ILE | 346 | LEU | 0.000 | 0.947 | -0.947 | 0.947 |
| 95 | GLY | 173 | GLU | 1.080 | 0.140 | 0.940 | 0.940 |
| 285 | TRP | 316 | TYR | 0.000 | 0.936 | -0.936 | 0.936 |
| 51 | VAL | 62 | HIS | 0.178 | 1.112 | -0.933 | 0.933 |
| 235 | ARG | 459 | LEU | 0.000 | 0.930 | -0.930 | 0.930 |
| 124 | ARG | 134 | TYR | 0.000 | 0.928 | -0.928 | 0.928 |
| 414 | LYS | 415 | ASP | 6.153 | 5.229 | 0.924 | 0.924 |
| 159 | ILE | 162 | LEU | 0.000 | 0.919 | -0.919 | 0.919 |
| 442 | SER | 443 | LEU | 0.915 | 0.000 | 0.915 | 0.915 |
| 371 | HIS | 374 | MET | 0.000 | 0.915 | -0.915 | 0.915 |
| 79 | VAL | 106 | ASP | 4.248 | 3.334 | 0.914 | 0.914 |
| 62 | HIS | 332 | GLU | 0.914 | 0.000 | 0.914 | 0.914 |
| 113 | SER | 322 | ASN | 0.898 | 0.000 | 0.898 | 0.898 |
| 181 | GLU | 296 | SER | 0.000 | 0.888 | -0.888 | 0.888 |
| 121 | SER | 203 | MET | 3.033 | 2.147 | 0.886 | 0.886 |
| 137 | ILE | 142 | ARG | 4.480 | 3.599 | 0.881 | 0.881 |
| 85 | ILE | 94 | PHE | 0.800 | 1.679 | -0.880 | 0.880 |
| 222 | LEU | 224 | THR | 0.000 | 0.876 | -0.876 | 0.876 |
| 194 | TYR | 289 | PHE | 3.902 | 3.036 | 0.866 | 0.866 |
| 374 | MET | 386 | TYR | 0.000 | 0.866 | -0.866 | 0.866 |
| 384 | THR | 400 | PHE | 0.000 | 0.864 | -0.864 | 0.864 |
| 379 | VAL | 385 | PHE | 0.000 | 0.863 | -0.863 | 0.863 |
| 75 | LEU | 109 | CYS | 3.230 | 2.369 | 0.861 | 0.861 |
| 185 | VAL | 296 | SER | 2.343 | 1.491 | 0.852 | 0.852 |
| 106 | ASP | 312 | PHE | 1.352 | 0.507 | 0.845 | 0.845 |
| 376 | ARG | 385 | PHE | 0.024 | 0.864 | -0.839 | 0.839 |
| 323 | PRO | 337 | PHE | 0.000 | 0.836 | -0.836 | 0.836 |
| 222 | LEU | 235 | ARG | 0.000 | 0.835 | -0.835 | 0.835 |
| 159 | ILE | 163 | PHE | 2.994 | 2.160 | 0.834 | 0.834 |
| 108 | LEU | 158 | SER | 3.609 | 2.782 | 0.827 | 0.827 |
| 322 | ASN | 327 | PRO | 0.827 | 0.000 | 0.827 | 0.827 |
| 282 | VAL | 286 | LEU | 1.201 | 0.374 | 0.826 | 0.826 |
| 36 | LEU | 320 | CYS | 2.236 | 1.411 | 0.824 | 0.824 |
| 157 | ILE | 187 | PHE | 1.035 | 0.211 | 0.824 | 0.824 |
| 37 | ILE | 80 | LEU | 3.582 | 2.780 | 0.802 | 0.802 |
| 155 | LEU | 159 | ILE | 0.915 | 0.114 | 0.801 | 0.801 |
| 223 | LYS | 233 | THR | 0.000 | 0.799 | -0.799 | 0.799 |
| 373 | ASP | 387 | ARG | 0.000 | 0.797 | -0.797 | 0.797 |
| 333 | PHE | 337 | PHE | 1.063 | 0.273 | 0.791 | 0.791 |
| 191 | GLY | 196 | PRO | 1.695 | 2.484 | -0.788 | 0.788 |
| 235 | ARG | 458 | SER | 0.000 | 0.782 | -0.782 | 0.782 |
| 223 | LYS | 232 | VAL | 0.000 | 0.782 | -0.782 | 0.782 |
| 36 | LEU | 317 | LEU | 0.673 | 1.447 | -0.774 | 0.774 |
| 276 | ILE | 325 | ILE | 0.409 | 1.181 | -0.772 | 0.772 |
| 72 | ASP | 113 | SER | 3.631 | 2.862 | 0.769 | 0.769 |
| 280 | CYS | 325 | ILE | 1.553 | 0.786 | 0.767 | 0.767 |
| 362 | PRO | 363 | PRO | 1.008 | 0.244 | 0.763 | 0.763 |
| 122 | ILE | 199 | ILE | 1.029 | 0.272 | 0.757 | 0.757 |
| 178 | ILE | 308 | PHE | 1.011 | 0.258 | 0.753 | 0.753 |
| 87 | GLU | 309 | LYS | 7.612 | 8.358 | -0.746 | 0.746 |
| 204 | TYR | 326 | TYR | 0.738 | 0.000 | 0.738 | 0.738 |
| 161 | PRO | 179 | ASN | 1.481 | 0.747 | 0.734 | 0.734 |
| 65 | ILE | 333 | PHE | 0.539 | 1.270 | -0.731 | 0.731 |
| 236 | ILE | 237 | HIS | 0.730 | 0.000 | 0.730 | 0.730 |
| 102 | TRP | 178 | ILE | 0.000 | 0.722 | -0.722 | 0.722 |
| 160 | GLY | 184 | TYR | 0.650 | 1.369 | -0.720 | 0.720 |
| 179 | ASN | 184 | TYR | 4.571 | 3.860 | 0.710 | 0.710 |
| 128 | VAL | 211 | ALA | 0.000 | 0.707 | -0.707 | 0.707 |
| 68 | LEU | 72 | ASP | 1.829 | 1.129 | 0.700 | 0.700 |
| 22 | ASN | 25 | LYS | 1.646 | 2.337 | -0.692 | 0.692 |
| 322 | ASN | 326 | TYR | 1.330 | 0.640 | 0.690 | 0.690 |
| 292 | MET | 308 | PHE | 0.684 | 0.000 | 0.684 | 0.684 |
| 21 | VAL | 88 | VAL | 0.000 | 0.684 | -0.684 | 0.684 |
| 130 | TYR | 137 | ILE | 1.109 | 0.426 | 0.683 | 0.683 |
| 68 | LEU | 113 | SER | 2.547 | 3.229 | -0.681 | 0.681 |
| 378 | PRO | 385 | PHE | 0.679 | 0.000 | 0.679 | 0.679 |
| 52 | ALA | 58 | HIS | 0.000 | 0.677 | -0.677 | 0.677 |
| 375 | VAL | 386 | TYR | 0.000 | 0.676 | -0.676 | 0.676 |
| 82 | PHE | 94 | PHE | 3.564 | 4.229 | -0.666 | 0.666 |
| 44 | ASN | 76 | THR | 0.718 | 0.056 | 0.662 | 0.662 |
| 288 | PHE | 308 | PHE | 0.095 | 0.756 | -0.661 | 0.661 |
| 280 | CYS | 321 | ILE | 0.139 | 0.796 | -0.657 | 0.657 |
| 178 | ILE | 312 | PHE | 1.639 | 0.982 | 0.656 | 0.656 |
| 74 | LEU | 151 | TRP | 0.272 | 0.925 | -0.653 | 0.653 |
| 255 | THR | 459 | LEU | 0.000 | 0.648 | -0.648 | 0.648 |
| 216 | ARG | 267 | GLU | 0.646 | 0.000 | 0.646 | 0.646 |
| 272 | LYS | 276 | ILE | 0.927 | 0.282 | 0.645 | 0.645 |
| 201 | LEU | 278 | VAL | 0.642 | 0.000 | 0.642 | 0.642 |
| 53 | CYS | 54 | HIS | 0.374 | 1.016 | -0.642 | 0.642 |
| 57 | LEU | 332 | GLU | 0.824 | 0.186 | 0.638 | 0.638 |
| 50 | SER | 333 | PHE | 1.605 | 0.970 | 0.635 | 0.635 |
| 383 | GLU | 385 | PHE | 0.000 | 0.633 | -0.633 | 0.633 |
| 325 | ILE | 326 | TYR | 0.633 | 0.000 | 0.633 | 0.633 |
| 273 | THR | 325 | ILE | 0.000 | 0.629 | -0.629 | 0.629 |
| 68 | LEU | 120 | ILE | 0.842 | 0.216 | 0.626 | 0.626 |
| 285 | TRP | 289 | PHE | 2.608 | 3.232 | -0.625 | 0.625 |
| 2 | VAL | 3 | PHE | 0.000 | 0.614 | -0.614 | 0.614 |
| 54 | HIS | 340 | VAL | 0.609 | 0.000 | 0.609 | 0.609 |
| 417 | SER | 418 | SER | 0.000 | 0.607 | -0.607 | 0.607 |
| 86 | PHE | 176 | CYS | 1.669 | 1.066 | 0.603 | 0.603 |
| 269 | LYS | 329 | SER | 0.000 | 0.597 | -0.597 | 0.597 |
| 127 | GLY | 134 | TYR | 3.476 | 2.880 | 0.596 | 0.596 |
| 41 | VAL | 73 | LEU | 1.757 | 2.352 | -0.595 | 0.595 |
| 234 | LEU | 257 | PHE | 0.000 | 0.595 | -0.595 | 0.595 |
| 113 | SER | 319 | SER | 0.590 | 0.000 | 0.590 | 0.590 |
| 29 | LEU | 33 | LEU | 1.543 | 0.955 | 0.588 | 0.588 |
| 55 | ARG | 58 | HIS | 0.657 | 0.071 | 0.586 | 0.586 |
| 365 | GLN | 366 | ALA | 0.585 | 0.000 | 0.585 | 0.585 |
| 122 | ILE | 203 | MET | 1.133 | 1.712 | -0.579 | 0.579 |
| 76 | THR | 81 | PRO | 1.612 | 2.188 | -0.576 | 0.576 |
| 75 | LEU | 80 | LEU | 5.695 | 5.121 | 0.574 | 0.574 |
| 459 | LEU | 465 | GLU | 1.126 | 1.699 | -0.572 | 0.572 |
| 61 | THR | 123 | ASP | 5.550 | 4.978 | 0.572 | 0.572 |
| 200 | ILE | 204 | TYR | 1.349 | 0.780 | 0.569 | 0.569 |
| 234 | LEU | 457 | ILE | 0.000 | 0.568 | -0.568 | 0.568 |
| 294 | ILE | 301 | PHE | 0.983 | 0.416 | 0.567 | 0.567 |
| 181 | GLU | 184 | TYR | 0.369 | 0.936 | -0.566 | 0.566 |
| 428 | SER | 429 | PHE | 0.000 | 0.558 | -0.558 | 0.558 |
| 47 | VAL | 323 | PRO | 1.527 | 0.971 | 0.556 | 0.556 |
| 370 | GLN | 371 | HIS | 0.552 | 0.000 | 0.552 | 0.552 |
| 124 | ARG | 207 | VAL | 0.807 | 1.357 | -0.550 | 0.550 |
| 71 | ALA | 109 | CYS | 0.842 | 1.392 | -0.550 | 0.550 |
| 125 | TYR | 207 | VAL | 2.110 | 2.657 | -0.548 | 0.548 |
| 210 | VAL | 214 | GLU | 0.613 | 0.067 | 0.546 | 0.546 |
| 220 | SER | 222 | LEU | 0.000 | 0.543 | -0.543 | 0.543 |
| 282 | VAL | 287 | PRO | 0.778 | 0.235 | 0.542 | 0.542 |
| 75 | LEU | 319 | SER | 1.499 | 0.956 | 0.542 | 0.542 |
| 180 | GLU | 302 | LYS | 3.883 | 4.425 | -0.542 | 0.542 |
| 339 | ASN | 345 | CYS | 0.000 | 0.536 | -0.536 | 0.536 |
| 64 | TYR | 147 | LEU | 2.528 | 1.992 | 0.536 | 0.536 |
| 128 | VAL | 271 | ALA | 0.000 | 0.536 | -0.536 | 0.536 |
| 288 | PHE | 311 | VAL | 4.162 | 3.634 | 0.528 | 0.528 |
| 59 | SER | 140 | GLN | 0.525 | 0.000 | 0.525 | 0.525 |
| 1 | MET | 305 | GLU | 0.524 | 0.000 | 0.524 | 0.524 |
| 207 | VAL | 274 | LEU | 0.523 | 0.000 | 0.523 | 0.523 |
| 227 | SER | 428 | SER | 0.000 | 0.523 | -0.523 | 0.523 |
| 71 | ALA | 151 | TRP | 1.388 | 0.869 | 0.519 | 0.519 |
| 375 | VAL | 385 | PHE | 0.000 | 0.518 | -0.518 | 0.518 |
| 207 | VAL | 271 | ALA | 0.000 | 0.518 | -0.518 | 0.518 |
| 92 | TRP | 102 | TRP | 4.827 | 4.309 | 0.517 | 0.517 |
| 284 | CYS | 321 | ILE | 0.212 | 0.723 | -0.510 | 0.510 |
| 39 | PHE | 324 | ILE | 1.868 | 2.376 | -0.508 | 0.508 |
| 115 | MET | 153 | LEU | 1.106 | 0.599 | 0.507 | 0.507 |
| 204 | TYR | 271 | ALA | 0.000 | 0.502 | -0.502 | 0.502 |
| 158 | SER | 159 | ILE | 0.000 | 0.500 | -0.500 | 0.500 |
| 255 | THR | 258 | SER | 0.000 | 0.500 | -0.500 | 0.500 |
| 21 | VAL | 89 | LEU | 0.000 | 0.498 | -0.498 | 0.498 |
| 193 | PHE | 197 | LEU | 1.915 | 1.419 | 0.496 | 0.496 |
| 416 | GLN | 417 | SER | 0.678 | 0.185 | 0.492 | 0.492 |
| 259 | VAL | 263 | LYS | 0.991 | 0.501 | 0.491 | 0.491 |
| 40 | GLY | 320 | CYS | 1.432 | 0.942 | 0.490 | 0.490 |
| 107 | VAL | 188 | SER | 0.000 | 0.488 | -0.488 | 0.488 |
| 63 | TYR | 147 | LEU | 0.359 | 0.846 | -0.487 | 0.487 |
| 117 | LEU | 277 | VAL | 0.000 | 0.486 | -0.486 | 0.486 |
| 89 | LEU | 91 | TYR | 2.279 | 2.765 | -0.485 | 0.485 |
| 50 | SER | 337 | PHE | 3.266 | 2.785 | 0.481 | 0.481 |
| 383 | GLU | 399 | PHE | 0.000 | 0.479 | -0.479 | 0.479 |
| 352 | SER | 353 | LYS | 0.477 | 0.000 | 0.477 | 0.477 |
| 61 | THR | 274 | LEU | 0.000 | 0.477 | -0.477 | 0.477 |
| 157 | ILE | 191 | GLY | 1.187 | 1.662 | -0.476 | 0.476 |
| 424 | VAL | 426 | SER | 0.000 | 0.473 | -0.473 | 0.473 |
| 96 | ARG | 176 | CYS | 0.473 | 0.000 | 0.473 | 0.473 |
| 139 | THR | 142 | ARG | 2.155 | 2.621 | -0.465 | 0.465 |
| 387 | ARG | 395 | CYS | 0.000 | 0.465 | -0.465 | 0.465 |
| 50 | SER | 51 | VAL | 0.000 | 0.464 | -0.464 | 0.464 |
| 75 | LEU | 110 | CYS | 1.595 | 1.138 | 0.458 | 0.458 |
| 412 | VAL | 413 | SER | 1.831 | 1.374 | 0.457 | 0.457 |
| 64 | TYR | 146 | ALA | 0.547 | 0.091 | 0.456 | 0.456 |
| 102 | TRP | 106 | ASP | 0.456 | 0.000 | 0.456 | 0.456 |
| 194 | TYR | 293 | PRO | 0.000 | 0.455 | -0.455 | 0.455 |
| 114 | ILE | 193 | PHE | 0.065 | 0.519 | -0.454 | 0.454 |
| 126 | ILE | 134 | TYR | 1.252 | 0.798 | 0.454 | 0.454 |
| 128 | VAL | 210 | VAL | 2.079 | 1.629 | 0.449 | 0.449 |
| 78 | THR | 105 | VAL | 0.522 | 0.971 | -0.449 | 0.449 |
| 67 | ASN | 112 | ALA | 0.000 | 0.446 | -0.446 | 0.446 |
| 86 | PHE | 91 | TYR | 5.499 | 5.939 | -0.440 | 0.440 |
| 51 | VAL | 66 | VAL | 2.164 | 1.726 | 0.439 | 0.439 |
| 125 | TYR | 129 | SER | 4.739 | 4.300 | 0.439 | 0.439 |
| 60 | VAL | 134 | TYR | 0.092 | 0.526 | -0.434 | 0.434 |
| 218 | LEU | 264 | PHE | 0.000 | 0.433 | -0.433 | 0.433 |
| 51 | VAL | 57 | LEU | 2.607 | 2.181 | 0.425 | 0.425 |
| 121 | SER | 199 | ILE | 0.425 | 0.000 | 0.425 | 0.425 |
| 65 | ILE | 120 | ILE | 0.523 | 0.099 | 0.424 | 0.424 |
| 136 | THR | 142 | ARG | 0.721 | 0.300 | 0.421 | 0.421 |
| 190 | LEU | 196 | PRO | 0.241 | 0.662 | -0.421 | 0.421 |
| 3 | PHE | 4 | LEU | 0.000 | 0.419 | -0.419 | 0.419 |
| 117 | LEU | 318 | ASN | 0.418 | 0.000 | 0.418 | 0.418 |
| 276 | ILE | 329 | SER | 0.000 | 0.416 | -0.416 | 0.416 |
| 193 | PHE | 286 | LEU | 4.630 | 4.217 | 0.413 | 0.413 |
| 202 | VAL | 203 | MET | 0.140 | 0.552 | -0.413 | 0.413 |
| 269 | LYS | 331 | GLN | 0.000 | 0.412 | -0.412 | 0.412 |
| 128 | VAL | 207 | VAL | 0.420 | 0.829 | -0.409 | 0.409 |
| 29 | LEU | 88 | VAL | 0.029 | 0.430 | -0.401 | 0.401 |
| 199 | ILE | 203 | MET | 0.712 | 0.311 | 0.401 | 0.401 |
| 186 | LEU | 297 | PHE | 1.509 | 1.906 | -0.398 | 0.398 |
| 71 | ALA | 112 | ALA | 1.013 | 0.617 | 0.396 | 0.396 |
| 80 | LEU | 316 | TYR | 3.988 | 3.597 | 0.391 | 0.391 |
| 38 | LEU | 42 | LEU | 1.425 | 1.813 | -0.389 | 0.389 |
| 343 | ILE | 347 | CYS | 0.386 | 0.000 | 0.386 | 0.386 |
| 185 | VAL | 292 | MET | 1.565 | 1.948 | -0.382 | 0.382 |
| 119 | ILE | 150 | VAL | 1.081 | 1.462 | -0.382 | 0.382 |
| 395 | CYS | 397 | TRP | 0.448 | 0.067 | 0.380 | 0.380 |
| 121 | SER | 200 | ILE | 2.953 | 3.332 | -0.379 | 0.379 |
| 30 | GLY | 88 | VAL | 1.225 | 0.847 | 0.377 | 0.377 |
| 236 | ILE | 460 | SER | 0.000 | 0.368 | -0.368 | 0.368 |
| 230 | GLU | 231 | GLN | 0.366 | 0.000 | 0.366 | 0.366 |
| 111 | THR | 154 | SER | 4.848 | 5.212 | -0.363 | 0.363 |
| 93 | ALA | 94 | PHE | 0.471 | 0.113 | 0.358 | 0.358 |
| 59 | SER | 62 | HIS | 4.060 | 3.702 | 0.358 | 0.358 |
| 53 | CYS | 340 | VAL | 0.000 | 0.357 | -0.357 | 0.357 |
| 224 | THR | 231 | GLN | 0.000 | 0.357 | -0.357 | 0.357 |
| 83 | SER | 312 | PHE | 0.000 | 0.355 | -0.355 | 0.355 |
| 255 | THR | 257 | PHE | 0.000 | 0.355 | -0.355 | 0.355 |
| 117 | LEU | 278 | VAL | 0.000 | 0.353 | -0.353 | 0.353 |
| 440 | THR | 441 | PRO | 0.848 | 1.199 | -0.351 | 0.351 |
| 398 | LYS | 400 | PHE | 0.970 | 1.321 | -0.351 | 0.351 |
| 82 | PHE | 102 | TRP | 1.148 | 0.799 | 0.349 | 0.349 |
| 179 | ASN | 185 | VAL | 0.895 | 1.243 | -0.348 | 0.348 |
| 258 | SER | 259 | VAL | 0.000 | 0.347 | -0.347 | 0.347 |
| 102 | TRP | 316 | TYR | 0.577 | 0.233 | 0.344 | 0.344 |
| 167 | GLN | 179 | ASN | 2.480 | 2.136 | 0.344 | 0.344 |
| 67 | ASN | 147 | LEU | 3.557 | 3.899 | -0.342 | 0.342 |
| 228 | ASP | 229 | SER | 0.000 | 0.339 | -0.339 | 0.339 |
| 70 | VAL | 74 | LEU | 0.000 | 0.336 | -0.336 | 0.336 |
| 102 | TRP | 312 | PHE | 0.395 | 0.731 | -0.335 | 0.335 |
| 278 | VAL | 282 | VAL | 0.395 | 0.060 | 0.335 | 0.335 |
| 219 | LYS | 256 | HIS | 0.331 | 0.000 | 0.331 | 0.331 |
| 107 | VAL | 158 | SER | 1.270 | 1.601 | -0.331 | 0.331 |
| 65 | ILE | 274 | LEU | 0.000 | 0.329 | -0.329 | 0.329 |
| 121 | SER | 122 | ILE | 0.328 | 0.000 | 0.328 | 0.328 |
| 175 | ILE | 177 | GLN | 1.227 | 1.550 | -0.323 | 0.323 |
| 185 | VAL | 293 | PRO | 1.385 | 1.707 | -0.322 | 0.322 |
| 117 | LEU | 200 | ILE | 1.485 | 1.805 | -0.320 | 0.320 |
| 28 | LEU | 32 | ILE | 0.773 | 1.091 | -0.318 | 0.318 |
| 295 | GLY | 302 | LYS | 0.641 | 0.324 | 0.317 | 0.317 |
| 188 | SER | 192 | SER | 0.000 | 0.316 | -0.316 | 0.316 |
| 458 | SER | 464 | GLU | 0.154 | 0.470 | -0.316 | 0.316 |
| 239 | LYS | 242 | PRO | 0.000 | 0.314 | -0.314 | 0.314 |
| 117 | LEU | 120 | ILE | 0.000 | 0.312 | -0.312 | 0.312 |
| 118 | CYS | 122 | ILE | 0.311 | 0.000 | 0.311 | 0.311 |
| 75 | LEU | 106 | ASP | 1.107 | 1.411 | -0.304 | 0.304 |
| 76 | THR | 320 | CYS | 0.301 | 0.000 | 0.301 | 0.301 |
| 32 | ILE | 36 | LEU | 0.000 | 0.299 | -0.299 | 0.299 |
| 449 | VAL | 450 | PRO | 1.569 | 1.271 | 0.298 | 0.298 |
| 215 | SER | 264 | PHE | 0.000 | 0.297 | -0.297 | 0.297 |
| 133 | ARG | 136 | THR | 0.578 | 0.873 | -0.295 | 0.295 |
| 87 | GLU | 313 | TRP | 1.372 | 1.666 | -0.294 | 0.294 |
| 46 | LEU | 337 | PHE | 2.094 | 1.801 | 0.293 | 0.293 |
| 129 | SER | 130 | TYR | 1.393 | 1.683 | -0.291 | 0.291 |
| 218 | LEU | 257 | PHE | 0.000 | 0.290 | -0.290 | 0.290 |
| 179 | ASN | 181 | GLU | 1.750 | 1.461 | 0.290 | 0.290 |
| 304 | SER | 307 | VAL | 1.681 | 1.392 | 0.289 | 0.289 |
| 237 | HIS | 466 | VAL | 0.000 | 0.285 | -0.285 | 0.285 |
| 96 | ARG | 99 | CYS | 0.285 | 0.000 | 0.285 | 0.285 |
| 212 | LYS | 216 | ARG | 3.291 | 3.575 | -0.284 | 0.284 |
| 364 | SER | 365 | GLN | 0.000 | 0.281 | -0.281 | 0.281 |
| 419 | CYS | 420 | THR | 0.280 | 0.000 | 0.280 | 0.280 |
| 286 | LEU | 290 | LEU | 2.245 | 1.966 | 0.279 | 0.279 |
| 33 | LEU | 313 | TRP | 5.560 | 5.839 | -0.279 | 0.279 |
| 110 | CYS | 285 | TRP | 2.498 | 2.776 | -0.278 | 0.278 |
| 194 | TYR | 290 | LEU | 1.821 | 1.544 | 0.277 | 0.277 |
| 255 | THR | 463 | GLY | 0.000 | 0.277 | -0.277 | 0.277 |
| 155 | LEU | 158 | SER | 0.000 | 0.275 | -0.275 | 0.275 |
| 48 | ILE | 70 | VAL | 1.335 | 1.060 | 0.275 | 0.275 |
| 107 | VAL | 184 | TYR | 0.938 | 1.213 | -0.275 | 0.275 |
| 33 | LEU | 84 | ALA | 1.378 | 1.652 | -0.274 | 0.274 |
| 377 | ILE | 379 | VAL | 0.000 | 0.273 | -0.273 | 0.273 |
| 61 | THR | 134 | TYR | 1.894 | 2.166 | -0.272 | 0.272 |
| 60 | VAL | 139 | THR | 0.875 | 1.145 | -0.271 | 0.271 |
| 236 | ILE | 461 | GLU | 0.000 | 0.268 | -0.268 | 0.268 |
| 460 | SER | 462 | ASN | 0.333 | 0.601 | -0.268 | 0.268 |
| 280 | CYS | 318 | ASN | 0.828 | 0.563 | 0.265 | 0.265 |
| 391 | THR | 392 | ASP | 1.533 | 1.798 | -0.264 | 0.264 |
| 111 | THR | 192 | SER | 2.120 | 2.384 | -0.264 | 0.264 |
| 48 | ILE | 73 | LEU | 0.708 | 0.445 | 0.264 | 0.264 |
| 121 | SER | 204 | TYR | 4.420 | 4.157 | 0.263 | 0.263 |
| 92 | TRP | 94 | PHE | 3.187 | 2.925 | 0.262 | 0.262 |
| 102 | TRP | 176 | CYS | 1.328 | 1.067 | 0.262 | 0.262 |
| 211 | ALA | 270 | ALA | 0.261 | 0.000 | 0.261 | 0.261 |
| 303 | PRO | 307 | VAL | 0.649 | 0.910 | -0.261 | 0.261 |
| 157 | ILE | 188 | SER | 1.129 | 1.390 | -0.260 | 0.260 |
| 430 | LEU | 432 | VAL | 0.364 | 0.110 | 0.254 | 0.254 |
| 372 | LYS | 373 | ASP | 0.254 | 0.000 | 0.254 | 0.254 |
| 178 | ILE | 292 | MET | 0.000 | 0.252 | -0.252 | 0.252 |
| 91 | TYR | 93 | ALA | 0.304 | 0.556 | -0.252 | 0.252 |
| 358 | TYR | 359 | THR | 0.000 | 0.252 | -0.252 | 0.252 |
| 106 | ASP | 110 | CYS | 1.405 | 1.153 | 0.252 | 0.252 |
| 215 | SER | 216 | ARG | 0.252 | 0.000 | 0.252 | 0.252 |
| 54 | HIS | 56 | HIS | 3.508 | 3.759 | -0.251 | 0.251 |
| 180 | GLU | 185 | VAL | 1.771 | 1.522 | 0.249 | 0.249 |
| 67 | ASN | 116 | GLY | 0.019 | 0.268 | -0.249 | 0.249 |
| 108 | LEU | 151 | TRP | 0.795 | 0.547 | 0.248 | 0.248 |
| 116 | GLY | 150 | VAL | 0.326 | 0.573 | -0.248 | 0.248 |
| 114 | ILE | 200 | ILE | 0.142 | 0.387 | -0.244 | 0.244 |
| 133 | ARG | 137 | ILE | 0.763 | 1.007 | -0.244 | 0.244 |
| 75 | LEU | 79 | VAL | 1.771 | 1.527 | 0.243 | 0.243 |
| 8 | ALA | 9 | SER | 0.000 | 0.239 | -0.239 | 0.239 |
| 73 | LEU | 77 | SER | 0.238 | 0.000 | 0.238 | 0.238 |
| 57 | LEU | 333 | PHE | 0.000 | 0.234 | -0.234 | 0.234 |
| 377 | ILE | 384 | THR | 0.000 | 0.234 | -0.234 | 0.234 |
| 331 | GLN | 334 | LYS | 0.234 | 0.000 | 0.234 | 0.234 |
| 281 | PHE | 282 | VAL | 0.275 | 0.041 | 0.234 | 0.234 |
| 68 | LEU | 322 | ASN | 2.025 | 1.793 | 0.232 | 0.232 |
| 386 | TYR | 397 | TRP | 0.027 | 0.258 | -0.231 | 0.231 |
| 223 | LYS | 257 | PHE | 0.000 | 0.230 | -0.230 | 0.230 |
| 374 | MET | 387 | ARG | 0.000 | 0.230 | -0.230 | 0.230 |
| 386 | TYR | 398 | LYS | 0.000 | 0.229 | -0.229 | 0.229 |
| 452 | ILE | 454 | VAL | 0.438 | 0.209 | 0.228 | 0.228 |
| 121 | SER | 278 | VAL | 0.000 | 0.226 | -0.226 | 0.226 |
| 21 | VAL | 26 | ALA | 0.438 | 0.663 | -0.225 | 0.225 |
| 269 | LYS | 273 | THR | 0.225 | 0.000 | 0.225 | 0.225 |
| 126 | ILE | 138 | VAL | 1.122 | 0.899 | 0.224 | 0.224 |
| 112 | ALA | 151 | TRP | 2.146 | 1.922 | 0.224 | 0.224 |
| 274 | LEU | 326 | TYR | 0.000 | 0.223 | -0.223 | 0.223 |
| 453 | LYS | 455 | HIS | 0.399 | 0.176 | 0.223 | 0.223 |
| 115 | MET | 154 | SER | 0.300 | 0.078 | 0.222 | 0.222 |
| 131 | PRO | 263 | LYS | 0.000 | 0.221 | -0.221 | 0.221 |
| 54 | HIS | 57 | LEU | 0.928 | 1.149 | -0.221 | 0.221 |
| 107 | VAL | 157 | ILE | 0.715 | 0.494 | 0.221 | 0.221 |
| 292 | MET | 293 | PRO | 1.070 | 1.288 | -0.217 | 0.217 |
| 241 | ALA | 242 | PRO | 0.474 | 0.257 | 0.217 | 0.217 |
| 325 | ILE | 329 | SER | 0.000 | 0.216 | -0.216 | 0.216 |
| 48 | ILE | 66 | VAL | 0.108 | 0.320 | -0.212 | 0.212 |
| 330 | SER | 332 | GLU | 0.764 | 0.975 | -0.211 | 0.211 |
| 119 | ILE | 147 | LEU | 0.472 | 0.261 | 0.211 | 0.211 |
| 334 | LYS | 338 | GLN | 1.417 | 1.208 | 0.209 | 0.209 |
| 291 | VAL | 308 | PHE | 0.673 | 0.466 | 0.208 | 0.208 |
| 70 | VAL | 151 | TRP | 0.024 | 0.231 | -0.206 | 0.206 |
| 92 | TRP | 174 | THR | 6.506 | 6.305 | 0.201 | 0.201 |
| 105 | VAL | 158 | SER | 0.199 | 0.000 | 0.199 | 0.199 |
| 387 | ARG | 397 | TRP | 0.000 | 0.199 | -0.199 | 0.199 |
| 324 | ILE | 328 | CYS | 0.000 | 0.195 | -0.195 | 0.195 |
| 9 | SER | 10 | ASP | 0.081 | 0.276 | -0.195 | 0.195 |
| 134 | TYR | 138 | VAL | 4.100 | 4.293 | -0.193 | 0.193 |
| 68 | LEU | 277 | VAL | 0.000 | 0.192 | -0.192 | 0.192 |
| 123 | ASP | 134 | TYR | 6.193 | 6.384 | -0.191 | 0.191 |
| 46 | LEU | 341 | LEU | 1.023 | 0.834 | 0.189 | 0.189 |
| 158 | SER | 184 | TYR | 0.801 | 0.613 | 0.188 | 0.188 |
| 41 | VAL | 77 | SER | 0.896 | 0.709 | 0.187 | 0.187 |
| 37 | ILE | 81 | PRO | 1.462 | 1.649 | -0.187 | 0.187 |
| 186 | LEU | 190 | LEU | 1.580 | 1.766 | -0.186 | 0.186 |
| 225 | ASP | 227 | SER | 0.000 | 0.182 | -0.182 | 0.182 |
| 293 | PRO | 297 | PHE | 0.156 | 0.338 | -0.181 | 0.181 |
| 52 | ALA | 349 | LYS | 0.000 | 0.178 | -0.178 | 0.178 |
| 92 | TRP | 173 | GLU | 1.085 | 1.263 | -0.178 | 0.178 |
| 261 | LEU | 461 | GLU | 0.177 | 0.000 | 0.177 | 0.177 |
| 37 | ILE | 76 | THR | 1.079 | 0.903 | 0.176 | 0.176 |
| 350 | GLN | 354 | HIS | 0.176 | 0.000 | 0.176 | 0.176 |
| 41 | VAL | 45 | ILE | 0.790 | 0.615 | 0.175 | 0.175 |
| 26 | ALA | 88 | VAL | 2.040 | 1.866 | 0.174 | 0.174 |
| 62 | HIS | 65 | ILE | 0.000 | 0.174 | -0.174 | 0.174 |
| 60 | VAL | 143 | GLY | 0.623 | 0.450 | 0.173 | 0.173 |
| 225 | ASP | 231 | GLN | 0.000 | 0.172 | -0.172 | 0.172 |
| 314 | LEU | 317 | LEU | 0.272 | 0.103 | 0.170 | 0.170 |
| 215 | SER | 219 | LYS | 0.000 | 0.169 | -0.169 | 0.169 |
| 124 | ARG | 277 | VAL | 0.167 | 0.000 | 0.167 | 0.167 |
| 388 | ILE | 395 | CYS | 0.000 | 0.167 | -0.167 | 0.167 |
| 438 | PRO | 439 | SER | 0.166 | 0.000 | 0.166 | 0.166 |
| 33 | LEU | 87 | GLU | 0.323 | 0.159 | 0.164 | 0.164 |
| 83 | SER | 313 | TRP | 1.424 | 1.588 | -0.164 | 0.164 |
| 388 | ILE | 394 | VAL | 0.000 | 0.162 | -0.162 | 0.162 |
| 283 | LEU | 314 | LEU | 0.433 | 0.595 | -0.162 | 0.162 |
| 287 | PRO | 311 | VAL | 2.601 | 2.440 | 0.161 | 0.161 |
| 157 | ILE | 192 | SER | 0.623 | 0.463 | 0.160 | 0.160 |
| 121 | SER | 207 | VAL | 0.000 | 0.159 | -0.159 | 0.159 |
| 125 | TYR | 126 | ILE | 0.241 | 0.082 | 0.159 | 0.159 |
| 120 | ILE | 204 | TYR | 0.482 | 0.323 | 0.159 | 0.159 |
| 212 | LYS | 215 | SER | 0.156 | 0.000 | 0.156 | 0.156 |
| 190 | LEU | 195 | LEU | 2.801 | 2.957 | -0.156 | 0.156 |
| 86 | PHE | 92 | TRP | 5.427 | 5.582 | -0.156 | 0.156 |
| 33 | LEU | 36 | LEU | 0.000 | 0.154 | -0.154 | 0.154 |
| 122 | ILE | 126 | ILE | 0.768 | 0.614 | 0.153 | 0.153 |
| 377 | ILE | 385 | PHE | 2.859 | 2.706 | 0.153 | 0.153 |
| 68 | LEU | 326 | TYR | 1.055 | 0.902 | 0.152 | 0.152 |
| 291 | VAL | 303 | PRO | 1.641 | 1.489 | 0.152 | 0.152 |
| 126 | ILE | 137 | ILE | 1.117 | 1.269 | -0.152 | 0.152 |
| 114 | ILE | 196 | PRO | 1.204 | 1.356 | -0.151 | 0.151 |
| 427 | LYS | 428 | SER | 0.147 | 0.000 | 0.147 | 0.147 |
| 197 | LEU | 286 | LEU | 0.000 | 0.146 | -0.146 | 0.146 |
| 166 | ARG | 167 | GLN | 0.146 | 0.000 | 0.146 | 0.146 |
| 264 | PHE | 268 | LYS | 0.236 | 0.092 | 0.144 | 0.144 |
| 112 | ALA | 154 | SER | 3.763 | 3.621 | 0.142 | 0.142 |
| 126 | ILE | 130 | TYR | 0.190 | 0.048 | 0.141 | 0.141 |
| 287 | PRO | 314 | LEU | 0.503 | 0.643 | -0.141 | 0.141 |
| 304 | SER | 306 | THR | 0.322 | 0.462 | -0.140 | 0.140 |
| 150 | VAL | 154 | SER | 0.256 | 0.395 | -0.139 | 0.139 |
| 83 | SER | 102 | TRP | 4.009 | 4.147 | -0.139 | 0.139 |
| 284 | CYS | 285 | TRP | 0.139 | 0.277 | -0.138 | 0.138 |
| 64 | TYR | 143 | GLY | 3.891 | 3.755 | 0.136 | 0.136 |
| 144 | LEU | 148 | LEU | 0.137 | 0.001 | 0.136 | 0.136 |
| 189 | ALA | 293 | PRO | 0.439 | 0.304 | 0.135 | 0.135 |
| 389 | SER | 392 | ASP | 0.135 | 0.000 | 0.135 | 0.135 |
| 310 | ILE | 314 | LEU | 0.135 | 0.000 | 0.135 | 0.135 |
| 78 | THR | 102 | TRP | 0.000 | 0.134 | -0.134 | 0.134 |
| 366 | ALA | 367 | VAL | 0.733 | 0.599 | 0.133 | 0.133 |
| 136 | THR | 137 | ILE | 0.254 | 0.386 | -0.132 | 0.132 |
| 284 | CYS | 311 | VAL | 0.111 | 0.241 | -0.130 | 0.130 |
| 125 | TYR | 210 | VAL | 0.000 | 0.130 | -0.130 | 0.130 |
| 302 | LYS | 303 | PRO | 0.978 | 0.848 | 0.129 | 0.129 |
| 113 | SER | 318 | ASN | 0.128 | 0.000 | 0.128 | 0.128 |
| 65 | ILE | 327 | PRO | 0.127 | 0.000 | 0.127 | 0.127 |
| 373 | ASP | 389 | SER | 0.000 | 0.127 | -0.127 | 0.127 |
| 308 | PHE | 312 | PHE | 0.127 | 0.000 | 0.127 | 0.127 |
| 141 | ARG | 145 | MET | 0.125 | 0.000 | 0.125 | 0.125 |
| 22 | ASN | 24 | SER | 0.121 | 0.000 | 0.121 | 0.121 |
| 67 | ASN | 119 | ILE | 0.120 | 0.000 | 0.120 | 0.120 |
| 45 | ILE | 49 | LEU | 1.044 | 0.924 | 0.120 | 0.120 |
| 235 | ARG | 237 | HIS | 0.000 | 0.119 | -0.119 | 0.119 |
| 300 | ASP | 301 | PHE | 0.421 | 0.302 | 0.119 | 0.119 |
| 99 | CYS | 100 | ASN | 0.258 | 0.376 | -0.118 | 0.118 |
| 225 | ASP | 230 | GLU | 0.000 | 0.118 | -0.118 | 0.118 |
| 312 | PHE | 313 | TRP | 0.000 | 0.115 | -0.115 | 0.115 |
| 290 | LEU | 294 | ILE | 0.114 | 0.000 | 0.114 | 0.114 |
| 439 | SER | 440 | THR | 0.112 | 0.000 | 0.112 | 0.112 |
| 99 | CYS | 176 | CYS | 6.070 | 5.961 | 0.109 | 0.109 |
| 10 | ASP | 12 | SER | 0.000 | 0.108 | -0.108 | 0.108 |
| 218 | LEU | 236 | ILE | 0.000 | 0.107 | -0.107 | 0.107 |
| 195 | LEU | 199 | ILE | 0.627 | 0.520 | 0.106 | 0.106 |
| 306 | THR | 310 | ILE | 0.348 | 0.450 | -0.102 | 0.102 |
| 99 | CYS | 177 | GLN | 0.263 | 0.162 | 0.101 | 0.101 |
| 286 | LEU | 287 | PRO | 0.864 | 0.965 | -0.101 | 0.101 |
| 50 | SER | 336 | ALA | 1.674 | 1.574 | 0.100 | 0.100 |
| 137 | ILE | 138 | VAL | 0.403 | 0.502 | -0.100 | 0.100 |
| 115 | MET | 150 | VAL | 2.619 | 2.519 | 0.100 | 0.100 |
| 43 | GLY | 337 | PHE | 0.097 | 0.000 | 0.097 | 0.097 |
| 239 | LYS | 464 | GLU | 0.000 | 0.096 | -0.096 | 0.096 |
| 24 | SER | 25 | LYS | 0.257 | 0.162 | 0.095 | 0.095 |
| 40 | GLY | 319 | SER | 0.000 | 0.094 | -0.094 | 0.094 |
| 89 | LEU | 93 | ALA | 0.365 | 0.458 | -0.094 | 0.094 |
| 59 | SER | 61 | THR | 1.164 | 1.256 | -0.091 | 0.091 |
| 92 | TRP | 175 | ILE | 0.141 | 0.051 | 0.091 | 0.091 |
| 91 | TYR | 174 | THR | 1.967 | 2.057 | -0.090 | 0.090 |
| 72 | ASP | 323 | PRO | 0.090 | 0.000 | 0.090 | 0.090 |
| 85 | ILE | 89 | LEU | 1.117 | 1.030 | 0.087 | 0.087 |
| 47 | VAL | 69 | ALA | 1.160 | 1.076 | 0.083 | 0.083 |
| 462 | ASN | 464 | GLU | 0.000 | 0.083 | -0.083 | 0.083 |
| 57 | LEU | 336 | ALA | 0.409 | 0.492 | -0.083 | 0.083 |
| 126 | ILE | 131 | PRO | 0.063 | 0.146 | -0.083 | 0.083 |
| 274 | LEU | 279 | GLY | 0.082 | 0.000 | 0.082 | 0.082 |
| 134 | TYR | 135 | PRO | 1.578 | 1.660 | -0.082 | 0.082 |
| 321 | ILE | 325 | ILE | 1.564 | 1.482 | 0.082 | 0.082 |
| 459 | LEU | 466 | VAL | 0.176 | 0.258 | -0.082 | 0.082 |
| 77 | SER | 78 | THR | 0.806 | 0.727 | 0.079 | 0.079 |
| 80 | LEU | 313 | TRP | 0.181 | 0.261 | -0.079 | 0.079 |
| 461 | GLU | 462 | ASN | 0.090 | 0.011 | 0.079 | 0.079 |
| 66 | VAL | 70 | VAL | 0.334 | 0.256 | 0.078 | 0.078 |
| 108 | LEU | 154 | SER | 3.523 | 3.600 | -0.077 | 0.077 |
| 106 | ASP | 316 | TYR | 6.272 | 6.196 | 0.077 | 0.077 |
| 377 | ILE | 378 | PRO | 0.624 | 0.547 | 0.076 | 0.076 |
| 254 | LYS | 259 | VAL | 0.000 | 0.076 | -0.076 | 0.076 |
| 44 | ASN | 322 | ASN | 0.000 | 0.076 | -0.076 | 0.076 |
| 273 | THR | 330 | SER | 0.000 | 0.075 | -0.075 | 0.075 |
| 50 | SER | 57 | LEU | 1.177 | 1.102 | 0.075 | 0.075 |
| 45 | ILE | 73 | LEU | 1.251 | 1.176 | 0.075 | 0.075 |
| 79 | VAL | 80 | LEU | 0.030 | 0.105 | -0.074 | 0.074 |
| 457 | ILE | 465 | GLU | 1.103 | 1.176 | -0.073 | 0.073 |
| 75 | LEU | 316 | TYR | 1.203 | 1.130 | 0.073 | 0.073 |
| 273 | THR | 326 | TYR | 0.000 | 0.073 | -0.073 | 0.073 |
| 61 | THR | 65 | ILE | 0.038 | 0.111 | -0.073 | 0.073 |
| 192 | SER | 193 | PHE | 0.299 | 0.372 | -0.072 | 0.072 |
| 133 | ARG | 428 | SER | 0.000 | 0.070 | -0.070 | 0.070 |
| 326 | TYR | 327 | PRO | 0.936 | 0.868 | 0.068 | 0.068 |
| 288 | PHE | 293 | PRO | 0.191 | 0.124 | 0.067 | 0.067 |
| 217 | GLY | 223 | LYS | 0.000 | 0.067 | -0.067 | 0.067 |
| 377 | ILE | 383 | GLU | 0.000 | 0.065 | -0.065 | 0.065 |
| 386 | TYR | 400 | PHE | 0.000 | 0.065 | -0.065 | 0.065 |
| 332 | GLU | 335 | LYS | 0.000 | 0.065 | -0.065 | 0.065 |
| 81 | PRO | 82 | PHE | 0.000 | 0.064 | -0.064 | 0.064 |
| 86 | PHE | 174 | THR | 0.000 | 0.064 | -0.064 | 0.064 |
| 115 | MET | 196 | PRO | 0.963 | 0.898 | 0.064 | 0.064 |
| 296 | SER | 297 | PHE | 0.059 | 0.000 | 0.059 | 0.059 |
| 115 | MET | 191 | GLY | 0.124 | 0.183 | -0.059 | 0.059 |
| 68 | LEU | 116 | GLY | 0.057 | 0.000 | 0.057 | 0.057 |
| 281 | PHE | 286 | LEU | 0.117 | 0.060 | 0.056 | 0.056 |
| 111 | THR | 115 | MET | 0.360 | 0.415 | -0.056 | 0.056 |
| 184 | TYR | 188 | SER | 2.134 | 2.079 | 0.055 | 0.055 |
| 29 | LEU | 34 | GLY | 0.000 | 0.054 | -0.054 | 0.054 |
| 291 | VAL | 311 | VAL | 0.776 | 0.829 | -0.053 | 0.053 |
| 197 | LEU | 201 | LEU | 1.459 | 1.511 | -0.051 | 0.051 |
| 297 | PHE | 298 | PHE | 1.189 | 1.240 | -0.051 | 0.051 |
| 48 | ILE | 69 | ALA | 1.418 | 1.468 | -0.050 | 0.050 |
| 40 | GLY | 76 | THR | 1.727 | 1.678 | 0.049 | 0.049 |
| 76 | THR | 80 | LEU | 0.729 | 0.682 | 0.048 | 0.048 |
| 115 | MET | 118 | CYS | 0.000 | 0.047 | -0.047 | 0.047 |
| 322 | ASN | 323 | PRO | 0.928 | 0.975 | -0.046 | 0.046 |
| 74 | LEU | 79 | VAL | 0.421 | 0.465 | -0.045 | 0.045 |
| 188 | SER | 193 | PHE | 0.155 | 0.200 | -0.045 | 0.045 |
| 17 | PRO | 18 | PRO | 0.658 | 0.614 | 0.044 | 0.044 |
| 267 | GLU | 270 | ALA | 0.000 | 0.044 | -0.044 | 0.044 |
| 64 | TYR | 138 | VAL | 0.157 | 0.200 | -0.043 | 0.043 |
| 101 | ILE | 105 | VAL | 0.418 | 0.375 | 0.043 | 0.043 |
| 96 | ARG | 177 | GLN | 0.042 | 0.000 | 0.042 | 0.042 |
| 443 | LEU | 444 | ASP | 0.000 | 0.041 | -0.041 | 0.041 |
| 111 | THR | 157 | ILE | 0.673 | 0.714 | -0.041 | 0.041 |
| 275 | GLY | 280 | CYS | 0.041 | 0.000 | 0.041 | 0.041 |
| 46 | LEU | 340 | VAL | 0.667 | 0.707 | -0.040 | 0.040 |
| 79 | VAL | 316 | TYR | 1.263 | 1.303 | -0.040 | 0.040 |
| 139 | THR | 141 | ARG | 0.295 | 0.256 | 0.039 | 0.039 |
| 78 | THR | 79 | VAL | 0.618 | 0.579 | 0.039 | 0.039 |
| 84 | ALA | 313 | TRP | 2.208 | 2.170 | 0.038 | 0.038 |
| 170 | PRO | 175 | ILE | 0.000 | 0.037 | -0.037 | 0.037 |
| 98 | PHE | 102 | TRP | 0.000 | 0.036 | -0.036 | 0.036 |
| 276 | ILE | 280 | CYS | 0.326 | 0.290 | 0.036 | 0.036 |
| 184 | TYR | 189 | ALA | 0.013 | 0.049 | -0.036 | 0.036 |
| 30 | GLY | 35 | GLY | 0.000 | 0.036 | -0.036 | 0.036 |
| 167 | GLN | 168 | PRO | 0.845 | 0.880 | -0.035 | 0.035 |
| 64 | TYR | 120 | ILE | 2.110 | 2.145 | -0.035 | 0.035 |
| 80 | LEU | 320 | CYS | 0.034 | 0.000 | 0.034 | 0.034 |
| 47 | VAL | 65 | ILE | 0.709 | 0.676 | 0.033 | 0.033 |
| 386 | TYR | 396 | GLU | 0.000 | 0.033 | -0.033 | 0.033 |
| 110 | CYS | 316 | TYR | 0.097 | 0.065 | 0.032 | 0.032 |
| 67 | ASN | 150 | VAL | 0.021 | 0.053 | -0.032 | 0.032 |
| 307 | VAL | 311 | VAL | 0.076 | 0.108 | -0.031 | 0.031 |
| 85 | ILE | 90 | GLY | 0.031 | 0.000 | 0.031 | 0.031 |
| 298 | PHE | 301 | PHE | 0.763 | 0.732 | 0.031 | 0.031 |
| 123 | ASP | 138 | VAL | 1.160 | 1.130 | 0.031 | 0.031 |
| 227 | SER | 427 | LYS | 0.000 | 0.030 | -0.030 | 0.030 |
| 54 | HIS | 335 | LYS | 0.000 | 0.030 | -0.030 | 0.030 |
| 165 | TRP | 179 | ASN | 2.479 | 2.509 | -0.029 | 0.029 |
| 190 | LEU | 194 | TYR | 0.893 | 0.863 | 0.029 | 0.029 |
| 239 | LYS | 460 | SER | 0.000 | 0.028 | -0.028 | 0.028 |
| 107 | VAL | 111 | THR | 0.481 | 0.509 | -0.028 | 0.028 |
| 457 | ILE | 459 | LEU | 0.000 | 0.027 | -0.027 | 0.027 |
| 73 | LEU | 76 | THR | 0.252 | 0.278 | -0.026 | 0.026 |
| 403 | MET | 404 | PRO | 1.308 | 1.333 | -0.025 | 0.025 |
| 97 | VAL | 101 | ILE | 0.341 | 0.366 | -0.025 | 0.025 |
| 309 | LYS | 313 | TRP | 0.000 | 0.024 | -0.024 | 0.024 |
| 79 | VAL | 105 | VAL | 1.532 | 1.508 | 0.024 | 0.024 |
| 80 | LEU | 81 | PRO | 0.768 | 0.746 | 0.022 | 0.022 |
| 248 | MET | 252 | LYS | 0.020 | 0.000 | 0.020 | 0.020 |
| 114 | ILE | 289 | PHE | 0.966 | 0.986 | -0.020 | 0.020 |
| 102 | TRP | 103 | ALA | 0.679 | 0.659 | 0.020 | 0.020 |
| 16 | GLN | 17 | PRO | 0.472 | 0.453 | 0.019 | 0.019 |
| 99 | CYS | 166 | ARG | 0.214 | 0.196 | 0.018 | 0.018 |
| 325 | ILE | 330 | SER | 0.000 | 0.018 | -0.018 | 0.018 |
| 132 | LEU | 263 | LYS | 0.000 | 0.017 | -0.017 | 0.017 |
| 174 | THR | 175 | ILE | 0.463 | 0.446 | 0.017 | 0.017 |
| 27 | ILE | 31 | VAL | 0.153 | 0.137 | 0.016 | 0.016 |
| 298 | PHE | 299 | PRO | 0.170 | 0.155 | 0.015 | 0.015 |
| 19 | ALA | 20 | PRO | 0.565 | 0.579 | -0.014 | 0.014 |
| 111 | THR | 116 | GLY | 0.000 | 0.013 | -0.013 | 0.013 |
| 195 | LEU | 196 | PRO | 1.351 | 1.338 | 0.012 | 0.012 |
| 75 | LEU | 81 | PRO | 0.000 | 0.011 | -0.011 | 0.011 |
| 79 | VAL | 83 | SER | 0.600 | 0.590 | 0.011 | 0.011 |
| 250 | SER | 254 | LYS | 0.010 | 0.000 | 0.010 | 0.010 |
| 38 | LEU | 43 | GLY | 0.000 | 0.010 | -0.010 | 0.010 |
| 75 | LEU | 285 | TRP | 0.000 | 0.010 | -0.010 | 0.010 |
| 37 | ILE | 84 | ALA | 0.534 | 0.543 | -0.010 | 0.010 |
| 274 | LEU | 277 | VAL | 0.000 | 0.009 | -0.009 | 0.009 |
| 105 | VAL | 109 | CYS | 0.513 | 0.521 | -0.008 | 0.008 |
| 204 | TYR | 207 | VAL | 0.058 | 0.050 | 0.008 | 0.008 |
| 208 | TYR | 267 | GLU | 0.008 | 0.000 | 0.008 | 0.008 |
| 37 | ILE | 41 | VAL | 0.202 | 0.194 | 0.008 | 0.008 |
| 82 | PHE | 92 | TRP | 0.767 | 0.774 | -0.007 | 0.007 |
| 49 | LEU | 53 | CYS | 0.007 | 0.000 | 0.007 | 0.007 |
| 293 | PRO | 298 | PHE | 0.065 | 0.058 | 0.007 | 0.007 |
| 39 | PHE | 44 | ASN | 0.000 | 0.006 | -0.006 | 0.006 |
| 130 | TYR | 131 | PRO | 0.094 | 0.099 | -0.005 | 0.005 |
| 375 | VAL | 377 | ILE | 0.103 | 0.099 | 0.004 | 0.004 |
| 23 | ILE | 27 | ILE | 0.964 | 0.960 | 0.004 | 0.004 |
| 72 | ASP | 318 | ASN | 0.000 | 0.004 | -0.004 | 0.004 |
| 2 | VAL | 4 | LEU | 0.004 | 0.000 | 0.004 | 0.004 |
| 169 | ALA | 170 | PRO | 0.586 | 0.582 | 0.004 | 0.004 |
| 355 | ALA | 356 | LEU | 0.004 | 0.000 | 0.004 | 0.004 |
| 392 | ASP | 394 | VAL | 0.003 | 0.000 | 0.003 | 0.003 |
| 73 | LEU | 78 | THR | 0.002 | 0.000 | 0.002 | 0.002 |
| 128 | VAL | 268 | LYS | 0.000 | 0.001 | -0.001 | 0.001 |
| 178 | ILE | 288 | PHE | 0.000 | 0.001 | -0.001 | 0.001 |
| 294 | ILE | 299 | PRO | 0.073 | 0.073 | 0.000 | 0.000 |
| 432 | VAL | 434 | CYS | 0.551 | 0.551 | -0.000 | 0.000 |
RRCS change distribution
-0.16
Mean ΔRRCS
1.57
Std Dev
-0.04
Median
Magnitude classification
17
High (|Δ| ≥ 5.0)
72
Medium (2.2 ≤ |Δ| < 5.0)
694
Low (|Δ| < 2.2)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.19, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar