ADA1D
759
Total Contact Pairs
78
Significant Changes
14.97
Max Increase
-7.83
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | GLU496 | ARG498 | 15.182 | 0.213 | +14.969 | HIGH |
| 2 | ASP142 (2.50x50) | SER395 (7.46x46) | 9.420 | 0.792 | +8.628 | HIGH |
| 3 | ARG294 | GLU301 | 0.000 | 7.830 | -7.830 | HIGH |
| 4 | GLN447 | ASP448 | 7.786 | 0.000 | +7.786 | HIGH |
| 5 | GLU237 | THR249 | 0.458 | 8.175 | -7.717 | HIGH |
| 6 | ASP64 | ASN65 | 7.482 | 0.264 | +7.218 | HIGH |
| 7 | ASN65 | ARG66 | 8.427 | 1.548 | +6.879 | HIGH |
| 8 | THR285 (5.69x69) | GLU343 (6.30x30) | 6.630 | 0.000 | +6.630 | HIGH |
| 9 | PHE357 (6.44x44) | TRP361 (6.48x48) | 2.703 | 9.239 | -6.536 | HIGH |
| 10 | THR284 (5.68x68) | GLU343 (6.30x30) | 6.385 | 0.000 | +6.385 | HIGH |
| 11 | MET321 | ARG322 | 0.000 | 6.363 | -6.363 | HIGH |
| 12 | GLU295 | ARG336 | 6.324 | 0.000 | +6.324 | HIGH |
| 13 | GLU237 | GLU251 (5.35x36) | 3.334 | 9.489 | -6.154 | HIGH |
| 14 | TRP361 (6.48x48) | GLY391 (7.42x41) | 3.654 | 9.667 | -6.014 | HIGH |
| 15 | GLU237 | GLU250 | 0.083 | 5.837 | -5.754 | HIGH |
| 16 | THR284 (5.68x68) | PHE340 (6.27x27) | 0.000 | 5.731 | -5.731 | HIGH |
| 17 | ARG446 | GLN447 | 6.150 | 0.557 | +5.593 | HIGH |
| 18 | PHE357 (6.44x44) | ASN394 (7.45x45) | 0.105 | 5.473 | -5.369 | HIGH |
| 19 | GLU301 | ARG305 | 5.337 | 0.000 | +5.337 | HIGH |
| 20 | GLU295 | PHE329 | 5.317 | 0.000 | +5.317 | HIGH |
| 21 | TYR274 (5.58x58) | ALA351 (6.38x38) | 0.000 | 5.293 | -5.293 | HIGH |
| 22 | LYS293 | GLU295 | 0.000 | 4.956 | -4.956 | MED |
| 23 | THR131 (2.39x39) | ARG194 (3.50x50) | 0.000 | 4.831 | -4.831 | MED |
| 24 | TRP361 (6.48x48) | ASN394 (7.45x45) | 7.003 | 2.201 | +4.802 | MED |
| 25 | TRP235 (4.64x64) | GLU251 (5.35x36) | 4.707 | 0.000 | +4.707 | MED |
| 26 | ARG194 (3.50x50) | TYR274 (5.58x58) | 5.058 | 0.370 | +4.688 | MED |
| 27 | THR349 (6.36x36) | SER405 (7.56x56) | 1.245 | 5.900 | -4.655 | MED |
| 28 | ASN124 (1.60x60) | HIS126 (12.49x49) | 4.632 | 0.000 | +4.632 | MED |
| 29 | ILE184 (3.40x40) | TRP361 (6.48x48) | 4.626 | 0.000 | +4.626 | MED |
| 30 | GLU295 | LYS298 | 4.559 | 0.000 | +4.559 | MED |
| 31 | PRO403 (7.54x54) | LYS410 (8.51x51) | 0.717 | 5.252 | -4.535 | MED |
| 32 | ASN124 (1.60x60) | ARG415 (8.56x56) | 1.196 | 5.662 | -4.466 | MED |
| 33 | ARG415 (8.56x56) | GLN420 | 0.000 | 4.373 | -4.373 | MED |
| 34 | PRO403 (7.54x54) | PHE409 (8.50x50) | 4.907 | 0.636 | +4.272 | MED |
| 35 | TYR133 (2.41x41) | GLU210 (4.39x39) | 0.099 | 4.005 | -3.905 | MED |
| 36 | SER38 | GLU39 | 1.510 | 5.412 | -3.902 | MED |
| 37 | ILE184 (3.40x40) | PHE357 (6.44x44) | 1.317 | 5.190 | -3.873 | MED |
| 38 | GLU289 (5.73x73) | LYS293 | 3.866 | 0.000 | +3.866 | MED |
| 39 | ASP193 (3.49x49) | ARG194 (3.50x50) | 0.000 | 3.847 | -3.847 | MED |
| 40 | ARG194 (3.50x50) | TYR402 (7.53x53) | 3.836 | 0.000 | +3.836 | MED |
| 41 | SER287 (5.71x71) | VAL292 | 0.000 | 3.797 | -3.797 | MED |
| 42 | ARG4 | GLN95 (1.31x31) | 0.000 | 3.661 | -3.661 | MED |
| 43 | TYR195 (3.51x51) | MET273 (5.57x57) | 4.322 | 0.830 | +3.492 | MED |
| 44 | VAL46 | PRO47 | 0.000 | 3.464 | -3.464 | MED |
| 45 | TYR274 (5.58x58) | LEU350 (6.37x37) | 1.802 | 5.230 | -3.428 | MED |
| 46 | PRO403 (7.54x54) | PHE413 (8.54x54) | 0.000 | 3.424 | -3.424 | MED |
| 47 | PRO470 | ASP471 | 4.767 | 1.365 | +3.402 | MED |
| 48 | TYR402 (7.53x53) | PHE409 (8.50x50) | 0.000 | 3.400 | -3.400 | MED |
| 49 | PRO468 | ASP469 | 3.305 | 0.000 | +3.305 | MED |
| 50 | ARG194 (3.50x50) | GLU343 (6.30x30) | 0.000 | 3.303 | -3.303 | MED |
| 51 | GLN128 (12.51x51) | TYR133 (2.41x41) | 3.452 | 0.206 | +3.245 | MED |
| 52 | THR285 (5.69x69) | LYS344 (6.31x31) | 0.043 | 3.283 | -3.239 | MED |
| 53 | MET267 (5.51x51) | VAL358 (6.45x45) | 0.341 | 3.536 | -3.195 | MED |
| 54 | ARG166 (3.22x22) | PRO240 | 0.848 | 4.035 | -3.187 | MED |
| 55 | LYS339 (6.26x26) | GLU343 (6.30x30) | 3.180 | 0.000 | +3.180 | MED |
| 56 | THR570 | ASP571 | 3.151 | 0.000 | +3.151 | MED |
| 57 | GLY230 (4.59x59) | TRP235 (4.64x64) | 5.526 | 2.415 | +3.111 | MED |
| 58 | HIS437 | GLU552 | 0.000 | 3.083 | -3.083 | MED |
| 59 | THR285 (5.69x69) | GLU289 (5.73x73) | 0.000 | 3.064 | -3.064 | MED |
| 60 | LEU187 | TYR402 (7.53x53) | 2.900 | 0.000 | +2.900 | MED |
| 61 | LEU202 | ARG336 | 0.000 | 2.894 | -2.894 | MED |
| 62 | LEU288 | LYS339 (6.26x26) | 2.871 | 0.000 | +2.871 | MED |
| 63 | GLU157 | TRP389 | 4.584 | 1.724 | +2.860 | MED |
| 64 | THR181 | SER262 | 4.095 | 1.266 | +2.829 | MED |
| 65 | VAL227 | TYR254 | 3.210 | 0.408 | +2.802 | MED |
| 66 | ARG166 (3.22x22) | ASP170 | 3.388 | 0.593 | +2.794 | MED |
| 67 | SER191 | TYR274 (5.58x58) | 5.693 | 2.932 | +2.761 | MED |
| 68 | PHE134 | THR189 | 0.676 | 3.434 | -2.758 | MED |
| 69 | HIS126 (12.49x49) | ARG415 (8.56x56) | 2.717 | 0.000 | +2.717 | MED |
| 70 | ILE135 | TYR402 (7.53x53) | 0.428 | 3.096 | -2.668 | MED |
| 71 | ARG407 | GLU560 | 0.000 | 2.637 | -2.637 | MED |
| 72 | ILE270 | PHE357 (6.44x44) | 2.567 | 0.000 | +2.567 | MED |
| 73 | LEU187 | PHE357 (6.44x44) | 1.258 | 3.805 | -2.547 | MED |
| 74 | ASN114 | ASP142 (2.50x50) | 5.222 | 2.705 | +2.517 | MED |
| 75 | VAL117 | PHE413 (8.54x54) | 0.000 | 2.509 | -2.509 | MED |
| 76 | PHE364 | PHE365 | 3.450 | 1.014 | +2.436 | MED |
| 77 | LEU288 | GLU343 (6.30x30) | 2.365 | 0.000 | +2.365 | MED |
| 78 | TYR278 | ARG282 | 2.339 | 4.699 | -2.360 | MED |
| 79 | SER406 | GLU408 | 1.251 | 3.506 | -2.255 | LOW |
| 80 | LEU464 | THR465 | 2.776 | 0.532 | +2.245 | LOW |
| 81 | PRO37 | SER38 | 0.000 | 2.243 | -2.243 | LOW |
| 82 | SER486 | ARG487 | 0.000 | 2.241 | -2.241 | LOW |
| 83 | ALA281 | PHE340 (6.27x27) | 0.000 | 2.238 | -2.238 | LOW |
| 84 | SER153 | TYR392 | 3.690 | 1.468 | +2.223 | LOW |
| 85 | ASN394 (7.45x45) | ASN398 | 4.375 | 2.173 | +2.201 | LOW |
| 86 | TRP235 (4.64x64) | TYR254 | 3.527 | 1.352 | +2.175 | LOW |
| 87 | LEU288 | LEU337 | 0.000 | 2.135 | -2.135 | LOW |
| 88 | ARG166 (3.22x22) | VAL239 | 5.356 | 3.288 | +2.068 | LOW |
| 89 | SER332 | ARG336 | 2.022 | 0.000 | +2.022 | LOW |
| 90 | ALA255 | LEU368 | 0.290 | 2.293 | -2.003 | LOW |
| 91 | CYS123 | CYS421 | 0.000 | 1.978 | -1.978 | LOW |
| 92 | LEU138 | SER186 | 3.744 | 1.777 | +1.967 | LOW |
| 93 | ARG418 | GLN420 | 0.000 | 1.967 | -1.967 | LOW |
| 94 | GLY291 | ARG336 | 1.955 | 0.000 | +1.955 | LOW |
| 95 | VAL353 | ILE401 | 0.868 | 2.786 | -1.918 | LOW |
| 96 | ASP170 | LYS236 | 4.527 | 2.622 | +1.905 | LOW |
| 97 | ASP469 | PRO470 | 1.992 | 0.096 | +1.896 | LOW |
| 98 | LEU144 | THR148 | 0.000 | 1.869 | -1.869 | LOW |
| 99 | ALA456 | PRO457 | 1.968 | 0.117 | +1.851 | LOW |
| 100 | ASN132 | PHE409 (8.50x50) | 3.505 | 1.654 | +1.851 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.36 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 95-124 | 124 (4.6) | 1 | 95 (-3.7) | 1 |
| TM2 | 131-142 | 142 (8.6) | 1 | 131 (-4.8), 133 (-3.9) | 2 |
| TM3 | 166-195 | 184 (4.6), 195 (3.5) | 2 | 194 (-4.8), 193 (-3.8), 166 (-3.2) | 3 |
| TM4 | 210-235 | 235 (4.7), 230 (3.1) | 2 | 210 (-3.9) | 1 |
| TM5 | 251-289 | 285 (6.6), 284 (6.4), 289 (3.9), 273 (3.5) | 4 | 251 (-6.2), 274 (-5.3), 287 (-3.8), 267 (-3.2) | 4 |
| TM6 | 339-361 | 343 (6.6), 339 (3.2) | 2 | 357 (-6.5), 361 (-6.5), 340 (-5.7), 351 (-5.3), 349 (-4.7), 350 (-3.4), 344 (-3.2), 358 (-3.2) | 8 |
| TM7 | 391-405 | 395 (8.6), 402 (3.8) | 2 | 391 (-6.0), 394 (-5.4), 405 (-4.7), 403 (-4.5) | 4 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 126-128 | 126 (4.6), 128 (3.2) | 2 | - | 0 |
| ICL2 | - | - | 0 | - | 0 |
| ICL3 | 292-336 | 295 (6.3), 336 (6.3), 305 (5.3), 329 (5.3), 298 (4.6) | 5 | 294 (-7.8), 301 (-7.8), 321 (-6.4), 322 (-6.4), 293 (-5.0), 292 (-3.8) | 6 |
| ECL1 | - | - | 0 | - | 0 |
| ECL2 | 237-250 | - | 0 | 237 (-7.7), 249 (-7.7), 250 (-5.8), 240 (-3.2) | 4 |
| ECL3 | - | - | 0 | - | 0 |
| H8 | 409-415 | 409 (4.3) | 1 | 410 (-4.5), 415 (-4.5), 413 (-3.4) | 3 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
129 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 498 | p.Arg498Thr | c.1493G>C | 6.90e-07 | 1 / 0 | 14.97 | 0.136 | BENIGN | 0.84 | |
| 496 | p.Glu496Lys | c.1486G>A | 2.07e-06 | 3 / 0 | 14.97 | 0.135 | BENIGN | 0.77 | |
| 498 | p.Arg498Lys | c.1493G>A | 1.38e-06 | 2 / 0 | 14.97 | - | nan | - | |
| 142 | p.Asp142Glu | c.426C>A | 6.84e-07 | 1 / 0 | 8.63 | 0.999 | PATHOGENIC | 1.00 | |
| 395 | p.Ser395Ile | c.1184G>T | 6.85e-07 | 1 / 0 | 8.63 | 0.994 | PATHOGENIC | 0.99 | |
| 142 | p.Asp142Gly | c.425A>G | 4.11e-06 | 6 / 0 | 8.63 | - | nan | - | rs1465375495 |
| 142 | p.Asp142Val | c.425A>T | 2.05e-06 | 3 / 0 | 8.63 | - | nan | - | |
| 142 | p.Asp142Asn | c.424G>A | 1.37e-06 | 2 / 0 | 8.63 | - | nan | - | rs1278861117 |
| 301 | p.Glu301Gly | c.902A>G | 1.43e-06 | 2 / 0 | 7.83 | 0.411 | AMBIGUOUS | 0.58 | rs1308736704 |
| 294 | p.Arg294His | c.881G>A | 7.15e-07 | 1 / 0 | 7.83 | 0.265 | BENIGN | 0.47 | |
| 294 | p.Arg294Cys | c.880C>T | 1.43e-06 | 2 / 0 | 7.83 | - | nan | - | rs1256499442 |
| 294 | p.Arg294Gly | c.880C>G | 7.14e-07 | 1 / 0 | 7.83 | - | nan | - | |
| 448 | p.Asp448Asn | c.1342G>A | 2.19e-06 | 3 / 0 | 7.79 | 0.101 | BENIGN | 0.49 | |
| 249 | p.Thr249Ser | c.746C>G | 6.92e-07 | 1 / 0 | 7.72 | 0.616 | PATHOGENIC | 0.65 | |
| 237 | p.Glu237Gln | c.709G>C | 1.37e-06 | 2 / 0 | 7.72 | 0.286 | BENIGN | 0.66 | |
| 64 | p.Asp64Glu | c.192C>G | 6.42e-06 | 8 / 0 | 7.22 | 0.082 | BENIGN | 0.57 | rs900690349 |
| 65 | p.Asn65Ser | c.194A>G | 1.54e-06 | 2 / 0 | 7.22 | 0.081 | BENIGN | 0.60 | |
| 66 | p.Arg66Pro | c.197G>C | 7.68e-07 | 1 / 0 | 6.88 | 0.112 | BENIGN | 0.46 | |
| 66 | p.Arg66Trp | c.196C>T | 1.54e-06 | 2 / 0 | 6.88 | - | nan | - | |
| 66 | p.Arg66Gly | c.196C>G | 1.54e-06 | 2 / 0 | 6.88 | - | nan | - | |
| 343 | p.Glu343Gly | c.1028A>G | 6.89e-07 | 1 / 0 | 6.63 | 0.975 | PATHOGENIC | 0.87 | |
| 285 | p.Thr285Ala | c.853A>G | 1.42e-06 | 2 / 0 | 6.63 | 0.475 | AMBIGUOUS | 0.59 | rs1981383431 |
| 343 | p.Glu343Lys | c.1027G>A | 6.89e-07 | 1 / 0 | 6.63 | - | nan | - | |
| 361 | p.Trp361Cys | c.1083G>T | 7.03e-07 | 1 / 0 | 6.54 | 0.998 | PATHOGENIC | 0.98 | rs759820796 |
| 357 | p.Phe357Val | c.1069T>G | 6.96e-07 | 1 / 0 | 6.54 | 0.997 | PATHOGENIC | 0.98 | |
| 361 | p.Trp361Ser | c.1082G>C | 1.40e-06 | 2 / 0 | 6.54 | - | nan | - | |
| 284 | p.Thr284Ile | c.851C>T | 2.84e-06 | 4 / 0 | 6.39 | 0.927 | PATHOGENIC | 0.46 | rs745898638 |
| 284 | p.Thr284Ser | c.850A>T | 1.42e-06 | 2 / 0 | 6.39 | - | nan | - | |
| 321 | p.Met321Ile | c.963G>T | 2.12e-06 | 3 / 0 | 6.36 | 0.139 | BENIGN | 0.35 | rs1413775621 |
| 322 | p.Arg322His | c.965G>A | 2.12e-06 | 3 / 0 | 6.36 | 0.088 | BENIGN | 0.43 | |
| 322 | p.Arg322Leu | c.965G>T | 1.41e-06 | 2 / 0 | 6.36 | - | nan | - | rs866134089 |
| 322 | p.Arg322Ser | c.964C>A | 7.08e-07 | 1 / 0 | 6.36 | - | nan | - | rs61759840 |
| 322 | p.Arg322Gly | c.964C>G | 4.95e-06 | 7 / 0 | 6.36 | - | nan | - | rs61759840 |
| 322 | p.Arg322Cys | c.964C>T | 7.08e-07 | 1 / 0 | 6.36 | - | nan | - | rs61759840 |
| 321 | p.Met321Arg | c.962T>G | 7.08e-07 | 1 / 0 | 6.36 | - | nan | - | |
| 336 | p.Arg336His | c.1007G>A | 4.15e-06 | 6 / 0 | 6.32 | 0.661 | PATHOGENIC | 0.70 | rs780713146 |
| 295 | p.Glu295Val | c.884A>T | 1.43e-06 | 2 / 0 | 6.32 | 0.650 | PATHOGENIC | 0.51 | rs1892798955 |
| 336 | p.Arg336Gly | c.1006C>G | 6.93e-07 | 1 / 0 | 6.32 | - | nan | - | |
| 336 | p.Arg336Cys | c.1006C>T | 5.54e-06 | 8 / 0 | 6.32 | - | nan | - | rs1192475463 |
| 295 | p.Glu295Lys | c.883G>A | 7.15e-07 | 1 / 0 | 6.32 | - | nan | - | |
| 251 | p.Glu251Lys | c.751G>A | 6.94e-07 | 1 / 0 | 6.15 | 0.833 | PATHOGENIC | 0.65 | rs1472781546 |
| 391 | p.Gly391Asp | c.1172G>A | 6.85e-07 | 1 / 0 | 6.01 | 0.999 | PATHOGENIC | 0.99 | |
| 391 | p.Gly391Ser | c.1171G>A | 8.90e-06 | 13 / 0 | 6.01 | - | nan | - | rs1174103344 |
| 391 | p.Gly391Arg | c.1171G>C | 6.85e-07 | 1 / 0 | 6.01 | - | nan | - | |
| 250 | p.Glu250Asp | c.750G>T | 6.93e-07 | 1 / 0 | 5.75 | 0.830 | PATHOGENIC | 0.61 | |
| 250 | p.Glu250Asp | c.750G>C | 2.77e-06 | 4 / 0 | 5.75 | - | nan | - | |
| 250 | p.Glu250Gln | c.748G>C | 6.93e-07 | 1 / 0 | 5.75 | - | nan | - | |
| 250 | p.Glu250Lys | c.748G>A | 2.08e-06 | 3 / 0 | 5.75 | - | nan | - | rs1161048658 |
| 340 | p.Phe340Leu | c.1018T>C | 6.89e-07 | 1 / 0 | 5.73 | 0.999 | PATHOGENIC | 0.86 | rs1466150421 |
| 446 | p.Arg446His | c.1337G>A | 5.33e-05 | 73 / 0 | 5.59 | 0.078 | BENIGN | 0.47 | rs900444027 |
| 446 | p.Arg446Cys | c.1336C>T | 7.29e-07 | 1 / 0 | 5.59 | - | nan | - | rs1405319810 |
| 394 | p.Asn394Lys | c.1182C>A | 6.57e-06 | 1 / 0 | 5.37 | 1.000 | PATHOGENIC | 0.99 | rs1186435528 |
| 394 | p.Asn394Ser | c.1181A>G | 6.85e-07 | 1 / 0 | 5.37 | - | nan | - | |
| 305 | p.Arg305Leu | c.914G>T | 7.15e-07 | 1 / 0 | 5.34 | 0.979 | PATHOGENIC | 0.85 | |
| 305 | p.Arg305Cys | c.913C>T | 1.00e-05 | 14 / 0 | 5.34 | - | nan | - | rs1383965083 |
| 329 | p.Phe329Ile | c.985T>A | 6.57e-06 | 1 / 0 | 5.32 | 0.230 | BENIGN | 0.38 | rs1330943150 |
| 329 | p.Phe329Leu | c.985T>C | 1.40e-06 | 2 / 0 | 5.32 | - | nan | - | rs1330943150 |
| 274 | p.Tyr274Cys | c.821A>G | 1.62e-05 | 23 / 0 | 5.29 | 0.987 | PATHOGENIC | 0.99 | rs1261665531 |
| 351 | p.Ala351Ser | c.1051G>T | 2.07e-06 | 3 / 0 | 5.29 | 0.352 | AMBIGUOUS | 0.72 | rs1268992350 |
| 293 | p.Lys293Asn | c.879G>T | 7.14e-07 | 1 / 0 | 4.96 | 0.996 | PATHOGENIC | 0.62 | rs1239713289 |
| 293 | p.Lys293Asn | c.879G>C | 1.31e-05 | 2 / 0 | 4.96 | - | nan | - | rs1239713289 |
| 194 | p.Arg194Pro | c.581G>C | 6.87e-07 | 1 / 0 | 4.83 | 0.999 | PATHOGENIC | 0.98 | |
| 131 | p.Thr131Ser | c.391A>T | 6.84e-07 | 1 / 0 | 4.83 | 0.858 | PATHOGENIC | 0.89 | rs760506161 |
| 131 | p.Thr131Ala | c.391A>G | 2.74e-06 | 4 / 0 | 4.83 | - | nan | - | rs760506161 |
| 235 | p.Trp235Arg | c.703T>C | 6.57e-06 | 1 / 0 | 4.71 | 0.999 | PATHOGENIC | 0.95 | rs1981392532 |
| 405 | p.Ser405Tyr | c.1214C>A | 1.37e-06 | 2 / 0 | 4.66 | 0.395 | AMBIGUOUS | 0.42 | |
| 126 | p.His126Gln | c.378C>A | 2.74e-06 | 4 / 0 | 4.63 | 0.459 | AMBIGUOUS | 0.60 | rs751776652 |
| 124 | p.Asn124Ser | c.371A>G | 2.05e-06 | 3 / 0 | 4.63 | 0.172 | BENIGN | 0.50 | rs767850528 |
| 126 | p.His126Arg | c.377A>G | 6.84e-07 | 1 / 0 | 4.63 | - | nan | - | |
| 124 | p.Asn124His | c.370A>C | 2.81e-04 | 411 / 0 | 4.63 | - | nan | - | rs201013283 |
| 298 | p.Lys298Asn | c.894G>C | 7.15e-07 | 1 / 0 | 4.56 | 0.464 | AMBIGUOUS | 0.48 | rs778822406 |
| 298 | p.Lys298Glu | c.892A>G | 1.43e-06 | 2 / 0 | 4.56 | - | nan | - | rs1312807748 |
| 410 | p.Lys410Arg | c.1229A>G | 6.90e-07 | 1 / 0 | 4.54 | 0.095 | BENIGN | 0.75 | |
| 415 | p.Arg415His | c.1244G>A | 4.18e-06 | 6 / 0 | 4.47 | 0.194 | BENIGN | 0.55 | rs1461124562 |
| 415 | p.Arg415Ser | c.1243C>A | 5.57e-06 | 8 / 0 | 4.47 | - | nan | - | |
| 420 | p.Gln420Arg | c.1259A>G | 2.81e-05 | 38 / 1 | 4.37 | 0.072 | BENIGN | 0.48 | rs750808890 |
| 409 | p.Phe409Ser | c.1226T>C | 6.89e-07 | 1 / 0 | 4.27 | 0.998 | PATHOGENIC | 0.93 | |
| 133 | p.Tyr133Cys | c.398A>G | 1.37e-06 | 2 / 0 | 3.91 | 0.214 | BENIGN | 0.73 | rs771984267 |
| 210 | p.Glu210Gln | c.628G>C | 7.57e-06 | 11 / 0 | 3.91 | 0.145 | BENIGN | 0.49 | rs372903381 |
| 133 | p.Tyr133His | c.397T>C | 6.84e-07 | 1 / 0 | 3.91 | - | nan | - | |
| 38 | p.Ser38Leu | c.113C>T | 1.16e-06 | 1 / 0 | 3.90 | 0.120 | BENIGN | 0.65 | |
| 289 | p.Glu289Lys | c.865G>A | 7.13e-07 | 1 / 0 | 3.87 | 0.687 | PATHOGENIC | 0.48 | |
| 193 | p.Asp193Glu | c.579C>G | 8.92e-06 | 13 / 0 | 3.85 | 0.973 | PATHOGENIC | 0.98 | rs752857515 |
| 193 | p.Asp193Asn | c.577G>A | 6.86e-07 | 1 / 0 | 3.85 | - | nan | - | rs1177528594 |
| 402 | p.Tyr402Ser | c.1205A>C | 7.57e-06 | 11 / 0 | 3.84 | 0.977 | PATHOGENIC | 0.99 | rs1362894178 |
| 402 | p.Tyr402Cys | c.1205A>G | 2.06e-06 | 3 / 0 | 3.84 | - | nan | - | |
| 402 | p.Tyr402Phe | c.1205A>T | 6.88e-07 | 1 / 0 | 3.84 | - | nan | - | |
| 402 | p.Tyr402His | c.1204T>C | 2.74e-06 | 4 / 0 | 3.84 | - | nan | - | rs1434286765 |
| 292 | p.Val292Ile | c.874G>A | 2.14e-06 | 3 / 0 | 3.80 | 0.075 | BENIGN | 0.49 | rs538270081 |
| 292 | p.Val292Leu | c.874G>C | 7.14e-07 | 1 / 0 | 3.80 | - | nan | - | |
| 4 | p.Arg4His | c.11G>A | 8.31e-07 | 1 / 0 | 3.66 | 0.161 | BENIGN | 0.78 | |
| 95 | p.Gln95Lys | c.283C>A | 6.92e-07 | 1 / 0 | 3.66 | 0.129 | BENIGN | 0.51 | rs1226226169 |
| 95 | p.Gln95Glu | c.283C>G | 6.92e-07 | 1 / 0 | 3.66 | - | nan | - | |
| 273 | p.Met273Arg | c.818T>G | 7.03e-07 | 1 / 0 | 3.49 | 0.980 | PATHOGENIC | 0.65 | |
| 195 | p.Tyr195Ser | c.584A>C | 1.37e-06 | 2 / 0 | 3.49 | 0.954 | PATHOGENIC | 0.95 | rs1248606817 |
| 273 | p.Met273Thr | c.818T>C | 1.34e-05 | 19 / 0 | 3.49 | - | nan | - | rs1415749108 |
| 195 | p.Tyr195His | c.583T>C | 2.75e-06 | 4 / 0 | 3.49 | - | nan | - | rs755047014 |
| 46 | p.Val46Leu | c.136G>T | 1.14e-06 | 1 / 0 | 3.46 | 0.093 | BENIGN | 0.61 | rs1315690742 |
| 47 | p.Pro47Arg | c.140C>G | 2.20e-06 | 2 / 0 | 3.46 | 0.087 | BENIGN | 0.57 | |
| 47 | p.Pro47Leu | c.140C>T | 1.10e-06 | 1 / 0 | 3.46 | - | nan | - | rs1981425616 |
| 471 | p.Asp471Tyr | c.1411G>T | 4.61e-06 | 2 / 0 | 3.40 | 0.089 | BENIGN | 0.44 | rs757702323 |
| 470 | p.Pro470His | c.1409C>A | 7.41e-07 | 1 / 0 | 3.40 | 0.083 | BENIGN | 0.52 | |
| 471 | p.Asp471His | c.1411G>C | 1.38e-05 | 6 / 0 | 3.40 | - | nan | - | rs757702323 |
| 470 | p.Pro470Leu | c.1409C>T | 7.41e-06 | 10 / 0 | 3.40 | - | nan | - | rs1387764015 |
| 470 | p.Pro470Thr | c.1408C>A | 5.93e-06 | 8 / 0 | 3.40 | - | nan | - | rs781518731 |
| 470 | p.Pro470Ser | c.1408C>T | 7.41e-07 | 1 / 0 | 3.40 | - | nan | - | |
| 469 | p.Asp469His | c.1405G>C | 1.34e-04 | 58 / 0 | 3.31 | 0.090 | BENIGN | 0.38 | rs1980675897 |
| 468 | p.Pro468Arg | c.1403C>G | 1.49e-05 | 20 / 0 | 3.31 | 0.078 | BENIGN | 0.33 | rs746414852 |
| 344 | p.Lys344Asn | c.1032G>T | 8.40e-05 | 122 / 0 | 3.24 | 0.994 | PATHOGENIC | 0.74 | rs764659132 |
| 344 | p.Lys344Arg | c.1031A>G | 6.20e-06 | 9 / 0 | 3.24 | - | nan | - | rs775275250 |
| 267 | p.Met267Ile | c.801G>A | 7.00e-07 | 1 / 0 | 3.20 | 0.885 | PATHOGENIC | 0.62 | |
| 358 | p.Val358Met | c.1072G>A | 1.39e-06 | 2 / 0 | 3.20 | 0.389 | AMBIGUOUS | 0.67 | |
| 358 | p.Val358Leu | c.1072G>C | 3.48e-06 | 5 / 0 | 3.20 | - | nan | - | rs765627756 |
| 267 | p.Met267Thr | c.800T>C | 3.50e-06 | 5 / 0 | 3.20 | - | nan | - | |
| 267 | p.Met267Val | c.799A>G | 7.00e-07 | 1 / 0 | 3.20 | - | nan | - | |
| 166 | p.Arg166Gly | c.496C>G | 6.85e-07 | 1 / 0 | 3.19 | 0.645 | PATHOGENIC | 0.57 | rs753011248 |
| 240 | p.Pro240Leu | c.719C>T | 9.09e-05 | 132 / 0 | 3.19 | 0.453 | AMBIGUOUS | 0.63 | rs145000687 |
| 240 | p.Pro240Ser | c.718C>T | 1.38e-06 | 2 / 0 | 3.19 | - | nan | - | |
| 240 | p.Pro240Thr | c.718C>A | 6.88e-07 | 1 / 0 | 3.19 | - | nan | - | rs1483522083 |
| 166 | p.Arg166Ser | c.496C>A | 2.05e-06 | 3 / 0 | 3.19 | - | nan | - | rs753011248 |
| 339 | p.Lys339Arg | c.1016A>G | 6.90e-07 | 1 / 0 | 3.18 | 0.247 | BENIGN | 0.82 | rs756734203 |
| 339 | p.Lys339Glu | c.1015A>G | 1.17e-05 | 17 / 0 | 3.18 | - | nan | - | rs1241513659 |
| 339 | p.Lys339Gln | c.1015A>C | 6.90e-07 | 1 / 0 | 3.18 | - | nan | - | rs1241513659 |
| 570 | p.Thr570Ser | c.1709C>G | 6.89e-07 | 1 / 0 | 3.15 | 0.540 | AMBIGUOUS | 1.00 | |
| 230 | p.Gly230Arg | c.688G>A | 1.79e-05 | 26 / 0 | 3.11 | 0.995 | PATHOGENIC | 0.60 | rs778951804 |
| 437 | p.His437Gln | c.1311C>G | 7.23e-07 | 1 / 0 | 3.08 | 0.156 | BENIGN | 0.58 | |
| 552 | p.Glu552Lys | c.1654G>A | 6.44e-05 | 94 / 0 | 3.08 | 0.097 | BENIGN | 0.93 | rs759003942 |
| 437 | p.His437Asn | c.1309C>A | 5.78e-06 | 8 / 0 | 3.08 | - | nan | - | rs982328949 |
| 437 | p.His437Tyr | c.1309C>T | 2.17e-06 | 3 / 0 | 3.08 | - | nan | - | rs982328949 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.36, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 496 | GLU | 498 | ARG | 15.182 | 0.213 | 14.969 | 14.969 |
| 142 | ASP | 395 | SER | 9.420 | 0.792 | 8.628 | 8.628 |
| 294 | ARG | 301 | GLU | 0.000 | 7.830 | -7.830 | 7.830 |
| 447 | GLN | 448 | ASP | 7.786 | 0.000 | 7.786 | 7.786 |
| 237 | GLU | 249 | THR | 0.458 | 8.175 | -7.717 | 7.717 |
| 64 | ASP | 65 | ASN | 7.482 | 0.264 | 7.218 | 7.218 |
| 65 | ASN | 66 | ARG | 8.427 | 1.548 | 6.879 | 6.879 |
| 285 | THR | 343 | GLU | 6.630 | 0.000 | 6.630 | 6.630 |
| 357 | PHE | 361 | TRP | 2.703 | 9.239 | -6.536 | 6.536 |
| 284 | THR | 343 | GLU | 6.385 | 0.000 | 6.385 | 6.385 |
| 321 | MET | 322 | ARG | 0.000 | 6.363 | -6.363 | 6.363 |
| 295 | GLU | 336 | ARG | 6.324 | 0.000 | 6.324 | 6.324 |
| 237 | GLU | 251 | GLU | 3.334 | 9.489 | -6.154 | 6.154 |
| 361 | TRP | 391 | GLY | 3.654 | 9.667 | -6.014 | 6.014 |
| 237 | GLU | 250 | GLU | 0.083 | 5.837 | -5.754 | 5.754 |
| 284 | THR | 340 | PHE | 0.000 | 5.731 | -5.731 | 5.731 |
| 446 | ARG | 447 | GLN | 6.150 | 0.557 | 5.593 | 5.593 |
| 357 | PHE | 394 | ASN | 0.105 | 5.473 | -5.369 | 5.369 |
| 301 | GLU | 305 | ARG | 5.337 | 0.000 | 5.337 | 5.337 |
| 295 | GLU | 329 | PHE | 5.317 | 0.000 | 5.317 | 5.317 |
| 274 | TYR | 351 | ALA | 0.000 | 5.293 | -5.293 | 5.293 |
| 293 | LYS | 295 | GLU | 0.000 | 4.956 | -4.956 | 4.956 |
| 131 | THR | 194 | ARG | 0.000 | 4.831 | -4.831 | 4.831 |
| 361 | TRP | 394 | ASN | 7.003 | 2.201 | 4.802 | 4.802 |
| 235 | TRP | 251 | GLU | 4.707 | 0.000 | 4.707 | 4.707 |
| 194 | ARG | 274 | TYR | 5.058 | 0.370 | 4.688 | 4.688 |
| 349 | THR | 405 | SER | 1.245 | 5.900 | -4.655 | 4.655 |
| 124 | ASN | 126 | HIS | 4.632 | 0.000 | 4.632 | 4.632 |
| 184 | ILE | 361 | TRP | 4.626 | 0.000 | 4.626 | 4.626 |
| 295 | GLU | 298 | LYS | 4.559 | 0.000 | 4.559 | 4.559 |
| 403 | PRO | 410 | LYS | 0.717 | 5.252 | -4.535 | 4.535 |
| 124 | ASN | 415 | ARG | 1.196 | 5.662 | -4.466 | 4.466 |
| 415 | ARG | 420 | GLN | 0.000 | 4.373 | -4.373 | 4.373 |
| 403 | PRO | 409 | PHE | 4.907 | 0.636 | 4.272 | 4.272 |
| 133 | TYR | 210 | GLU | 0.099 | 4.005 | -3.905 | 3.905 |
| 38 | SER | 39 | GLU | 1.510 | 5.412 | -3.902 | 3.902 |
| 184 | ILE | 357 | PHE | 1.317 | 5.190 | -3.873 | 3.873 |
| 289 | GLU | 293 | LYS | 3.866 | 0.000 | 3.866 | 3.866 |
| 193 | ASP | 194 | ARG | 0.000 | 3.847 | -3.847 | 3.847 |
| 194 | ARG | 402 | TYR | 3.836 | 0.000 | 3.836 | 3.836 |
| 287 | SER | 292 | VAL | 0.000 | 3.797 | -3.797 | 3.797 |
| 4 | ARG | 95 | GLN | 0.000 | 3.661 | -3.661 | 3.661 |
| 195 | TYR | 273 | MET | 4.322 | 0.830 | 3.492 | 3.492 |
| 46 | VAL | 47 | PRO | 0.000 | 3.464 | -3.464 | 3.464 |
| 274 | TYR | 350 | LEU | 1.802 | 5.230 | -3.428 | 3.428 |
| 403 | PRO | 413 | PHE | 0.000 | 3.424 | -3.424 | 3.424 |
| 470 | PRO | 471 | ASP | 4.767 | 1.365 | 3.402 | 3.402 |
| 402 | TYR | 409 | PHE | 0.000 | 3.400 | -3.400 | 3.400 |
| 468 | PRO | 469 | ASP | 3.305 | 0.000 | 3.305 | 3.305 |
| 194 | ARG | 343 | GLU | 0.000 | 3.303 | -3.303 | 3.303 |
| 128 | GLN | 133 | TYR | 3.452 | 0.206 | 3.245 | 3.245 |
| 285 | THR | 344 | LYS | 0.043 | 3.283 | -3.239 | 3.239 |
| 267 | MET | 358 | VAL | 0.341 | 3.536 | -3.195 | 3.195 |
| 166 | ARG | 240 | PRO | 0.848 | 4.035 | -3.187 | 3.187 |
| 339 | LYS | 343 | GLU | 3.180 | 0.000 | 3.180 | 3.180 |
| 570 | THR | 571 | ASP | 3.151 | 0.000 | 3.151 | 3.151 |
| 230 | GLY | 235 | TRP | 5.526 | 2.415 | 3.111 | 3.111 |
| 437 | HIS | 552 | GLU | 0.000 | 3.083 | -3.083 | 3.083 |
| 285 | THR | 289 | GLU | 0.000 | 3.064 | -3.064 | 3.064 |
| 187 | LEU | 402 | TYR | 2.900 | 0.000 | 2.900 | 2.900 |
| 202 | LEU | 336 | ARG | 0.000 | 2.894 | -2.894 | 2.894 |
| 288 | LEU | 339 | LYS | 2.871 | 0.000 | 2.871 | 2.871 |
| 157 | GLU | 389 | TRP | 4.584 | 1.724 | 2.860 | 2.860 |
| 181 | THR | 262 | SER | 4.095 | 1.266 | 2.829 | 2.829 |
| 227 | VAL | 254 | TYR | 3.210 | 0.408 | 2.802 | 2.802 |
| 166 | ARG | 170 | ASP | 3.388 | 0.593 | 2.794 | 2.794 |
| 191 | SER | 274 | TYR | 5.693 | 2.932 | 2.761 | 2.761 |
| 134 | PHE | 189 | THR | 0.676 | 3.434 | -2.758 | 2.758 |
| 126 | HIS | 415 | ARG | 2.717 | 0.000 | 2.717 | 2.717 |
| 135 | ILE | 402 | TYR | 0.428 | 3.096 | -2.668 | 2.668 |
| 407 | ARG | 560 | GLU | 0.000 | 2.637 | -2.637 | 2.637 |
| 270 | ILE | 357 | PHE | 2.567 | 0.000 | 2.567 | 2.567 |
| 187 | LEU | 357 | PHE | 1.258 | 3.805 | -2.547 | 2.547 |
| 114 | ASN | 142 | ASP | 5.222 | 2.705 | 2.517 | 2.517 |
| 117 | VAL | 413 | PHE | 0.000 | 2.509 | -2.509 | 2.509 |
| 364 | PHE | 365 | PHE | 3.450 | 1.014 | 2.436 | 2.436 |
| 288 | LEU | 343 | GLU | 2.365 | 0.000 | 2.365 | 2.365 |
| 278 | TYR | 282 | ARG | 2.339 | 4.699 | -2.360 | 2.360 |
| 406 | SER | 408 | GLU | 1.251 | 3.506 | -2.255 | 2.255 |
| 464 | LEU | 465 | THR | 2.776 | 0.532 | 2.245 | 2.245 |
| 37 | PRO | 38 | SER | 0.000 | 2.243 | -2.243 | 2.243 |
| 486 | SER | 487 | ARG | 0.000 | 2.241 | -2.241 | 2.241 |
| 281 | ALA | 340 | PHE | 0.000 | 2.238 | -2.238 | 2.238 |
| 153 | SER | 392 | TYR | 3.690 | 1.468 | 2.223 | 2.223 |
| 394 | ASN | 398 | ASN | 4.375 | 2.173 | 2.201 | 2.201 |
| 235 | TRP | 254 | TYR | 3.527 | 1.352 | 2.175 | 2.175 |
| 288 | LEU | 337 | LEU | 0.000 | 2.135 | -2.135 | 2.135 |
| 166 | ARG | 239 | VAL | 5.356 | 3.288 | 2.068 | 2.068 |
| 332 | SER | 336 | ARG | 2.022 | 0.000 | 2.022 | 2.022 |
| 255 | ALA | 368 | LEU | 0.290 | 2.293 | -2.003 | 2.003 |
| 123 | CYS | 421 | CYS | 0.000 | 1.978 | -1.978 | 1.978 |
| 138 | LEU | 186 | SER | 3.744 | 1.777 | 1.967 | 1.967 |
| 418 | ARG | 420 | GLN | 0.000 | 1.967 | -1.967 | 1.967 |
| 291 | GLY | 336 | ARG | 1.955 | 0.000 | 1.955 | 1.955 |
| 353 | VAL | 401 | ILE | 0.868 | 2.786 | -1.918 | 1.918 |
| 170 | ASP | 236 | LYS | 4.527 | 2.622 | 1.905 | 1.905 |
| 469 | ASP | 470 | PRO | 1.992 | 0.096 | 1.896 | 1.896 |
| 144 | LEU | 148 | THR | 0.000 | 1.869 | -1.869 | 1.869 |
| 456 | ALA | 457 | PRO | 1.968 | 0.117 | 1.851 | 1.851 |
| 132 | ASN | 409 | PHE | 3.505 | 1.654 | 1.851 | 1.851 |
| 480 | MET | 481 | GLN | 4.960 | 3.123 | 1.837 | 1.837 |
| 274 | TYR | 353 | VAL | 1.826 | 0.000 | 1.826 | 1.826 |
| 191 | SER | 273 | MET | 2.587 | 4.401 | -1.814 | 1.814 |
| 540 | GLU | 542 | VAL | 0.000 | 1.806 | -1.806 | 1.806 |
| 413 | PHE | 417 | LEU | 1.797 | 0.000 | 1.797 | 1.797 |
| 190 | ILE | 194 | ARG | 2.005 | 0.211 | 1.794 | 1.794 |
| 142 | ASP | 398 | ASN | 4.787 | 2.994 | 1.793 | 1.793 |
| 184 | ILE | 263 | PHE | 0.000 | 1.782 | -1.782 | 1.782 |
| 361 | TRP | 392 | TYR | 0.000 | 1.748 | -1.748 | 1.748 |
| 353 | VAL | 398 | ASN | 0.000 | 1.747 | -1.747 | 1.747 |
| 448 | ASP | 449 | CYS | 1.731 | 0.000 | 1.731 | 1.731 |
| 188 | CYS | 266 | PRO | 1.415 | 3.139 | -1.723 | 1.723 |
| 165 | GLY | 243 | GLU | 1.704 | 0.000 | 1.704 | 1.704 |
| 428 | ARG | 430 | LEU | 0.000 | 1.670 | -1.670 | 1.670 |
| 126 | HIS | 127 | LEU | 1.669 | 0.000 | 1.669 | 1.669 |
| 467 | LEU | 468 | PRO | 3.358 | 1.693 | 1.665 | 1.665 |
| 359 | LEU | 390 | LEU | 2.128 | 0.467 | 1.661 | 1.661 |
| 389 | TRP | 392 | TYR | 2.631 | 0.972 | 1.658 | 1.658 |
| 190 | ILE | 350 | LEU | 0.000 | 1.643 | -1.643 | 1.643 |
| 190 | ILE | 402 | TYR | 1.634 | 0.000 | 1.634 | 1.634 |
| 138 | LEU | 187 | LEU | 2.388 | 0.756 | 1.632 | 1.632 |
| 270 | ILE | 354 | VAL | 0.064 | 1.684 | -1.620 | 1.620 |
| 138 | LEU | 398 | ASN | 3.282 | 1.697 | 1.585 | 1.585 |
| 199 | ARG | 280 | VAL | 0.000 | 1.575 | -1.575 | 1.575 |
| 236 | LYS | 249 | THR | 1.462 | 3.034 | -1.572 | 1.572 |
| 152 | PHE | 164 | PHE | 2.399 | 3.962 | -1.563 | 1.563 |
| 23 | SER | 24 | SER | 0.498 | 2.055 | -1.556 | 1.556 |
| 156 | MET | 246 | CYS | 0.728 | 2.282 | -1.554 | 1.554 |
| 263 | PHE | 357 | PHE | 1.958 | 0.430 | 1.528 | 1.528 |
| 231 | PRO | 236 | LYS | 1.833 | 0.309 | 1.524 | 1.524 |
| 479 | GLU | 480 | MET | 9.462 | 7.944 | 1.519 | 1.519 |
| 93 | SER | 95 | GLN | 2.108 | 0.609 | 1.498 | 1.498 |
| 109 | MET | 396 | CYS | 0.741 | 2.238 | -1.497 | 1.497 |
| 292 | VAL | 303 | VAL | 0.000 | 1.479 | -1.479 | 1.479 |
| 360 | CYS | 394 | ASN | 3.584 | 2.107 | 1.477 | 1.477 |
| 401 | ILE | 402 | TYR | 1.471 | 0.000 | 1.471 | 1.471 |
| 187 | LEU | 398 | ASN | 1.464 | 0.000 | 1.464 | 1.464 |
| 239 | VAL | 240 | PRO | 1.728 | 0.278 | 1.450 | 1.450 |
| 299 | ALA | 329 | PHE | 1.442 | 0.000 | 1.442 | 1.442 |
| 149 | VAL | 176 | ASP | 4.354 | 2.927 | 1.427 | 1.427 |
| 122 | ALA | 128 | GLN | 0.060 | 1.485 | -1.425 | 1.425 |
| 114 | ASN | 139 | ALA | 5.983 | 4.564 | 1.419 | 1.419 |
| 559 | TYR | 563 | ASP | 1.415 | 0.000 | 1.415 | 1.415 |
| 166 | ARG | 236 | LYS | 1.413 | 0.000 | 1.413 | 1.413 |
| 434 | TYR | 438 | TRP | 0.000 | 1.413 | -1.413 | 1.413 |
| 117 | VAL | 402 | TYR | 0.000 | 1.411 | -1.411 | 1.411 |
| 113 | GLY | 399 | PRO | 3.251 | 4.647 | -1.396 | 1.396 |
| 134 | PHE | 193 | ASP | 4.035 | 2.657 | 1.378 | 1.378 |
| 282 | ARG | 286 | ARG | 0.898 | 2.267 | -1.369 | 1.369 |
| 137 | ASN | 217 | LEU | 3.623 | 4.990 | -1.368 | 1.368 |
| 267 | MET | 357 | PHE | 1.498 | 0.136 | 1.362 | 1.362 |
| 315 | ALA | 316 | ASP | 2.356 | 0.998 | 1.358 | 1.358 |
| 194 | ARG | 350 | LEU | 0.034 | 1.389 | -1.355 | 1.355 |
| 289 | GLU | 340 | PHE | 1.354 | 0.000 | 1.354 | 1.354 |
| 408 | GLU | 411 | ARG | 1.339 | 0.000 | 1.339 | 1.339 |
| 188 | CYS | 269 | VAL | 1.367 | 0.038 | 1.329 | 1.329 |
| 178 | LEU | 225 | LEU | 1.739 | 3.059 | -1.320 | 1.320 |
| 416 | LEU | 421 | CYS | 0.000 | 1.314 | -1.314 | 1.314 |
| 162 | TRP | 244 | ARG | 6.267 | 4.965 | 1.302 | 1.302 |
| 567 | LEU | 571 | ASP | 1.300 | 0.000 | 1.300 | 1.300 |
| 184 | ILE | 365 | PHE | 1.295 | 0.000 | 1.295 | 1.295 |
| 74 | SER | 75 | ALA | 0.049 | 1.339 | -1.290 | 1.290 |
| 144 | LEU | 179 | CYS | 1.023 | 2.310 | -1.287 | 1.287 |
| 116 | LEU | 413 | PHE | 2.610 | 3.888 | -1.278 | 1.278 |
| 141 | ALA | 183 | SER | 1.355 | 2.628 | -1.274 | 1.274 |
| 318 | ALA | 319 | HIS | 0.000 | 1.267 | -1.267 | 1.267 |
| 465 | THR | 466 | ALA | 0.000 | 1.267 | -1.267 | 1.267 |
| 114 | ASN | 143 | LEU | 2.211 | 0.955 | 1.257 | 1.257 |
| 273 | MET | 276 | ARG | 0.000 | 1.251 | -1.251 | 1.251 |
| 119 | LEU | 416 | LEU | 1.403 | 2.632 | -1.230 | 1.230 |
| 242 | ASP | 245 | PHE | 1.213 | 0.000 | 1.213 | 1.213 |
| 3 | PHE | 7 | LEU | 1.239 | 2.446 | -1.207 | 1.207 |
| 176 | ASP | 388 | PHE | 1.197 | 0.000 | 1.197 | 1.197 |
| 497 | TRP | 499 | LEU | 0.000 | 1.192 | -1.192 | 1.192 |
| 291 | GLY | 304 | LEU | 0.000 | 1.187 | -1.187 | 1.187 |
| 162 | TRP | 243 | GLU | 2.222 | 1.036 | 1.186 | 1.186 |
| 145 | LEU | 180 | CYS | 1.532 | 0.347 | 1.185 | 1.185 |
| 333 | LEU | 336 | ARG | 0.000 | 1.183 | -1.183 | 1.183 |
| 117 | VAL | 403 | PRO | 1.169 | 0.000 | 1.169 | 1.169 |
| 207 | ILE | 212 | LYS | 4.507 | 3.341 | 1.166 | 1.166 |
| 333 | LEU | 337 | LEU | 1.155 | 0.000 | 1.155 | 1.155 |
| 362 | PHE | 366 | PHE | 2.248 | 1.099 | 1.149 | 1.149 |
| 568 | ARG | 571 | ASP | 1.149 | 0.000 | 1.149 | 1.149 |
| 254 | TYR | 258 | SER | 3.134 | 4.275 | -1.141 | 1.141 |
| 1 | MET | 382 | GLY | 0.000 | 1.114 | -1.114 | 1.114 |
| 198 | VAL | 281 | ALA | 0.000 | 1.100 | -1.100 | 1.100 |
| 206 | ALA | 212 | LYS | 1.095 | 0.000 | 1.095 | 1.095 |
| 178 | LEU | 228 | SER | 3.814 | 2.734 | 1.080 | 1.080 |
| 235 | TRP | 253 | GLY | 1.078 | 0.000 | 1.078 | 1.078 |
| 181 | THR | 227 | VAL | 0.106 | 1.171 | -1.065 | 1.065 |
| 184 | ILE | 266 | PRO | 0.982 | 2.044 | -1.062 | 1.062 |
| 185 | LEU | 220 | LEU | 4.629 | 3.588 | 1.041 | 1.041 |
| 176 | ASP | 392 | TYR | 5.885 | 4.845 | 1.040 | 1.040 |
| 127 | LEU | 408 | GLU | 1.764 | 0.724 | 1.039 | 1.039 |
| 42 | ALA | 43 | VAL | 0.405 | 1.442 | -1.037 | 1.037 |
| 138 | LEU | 183 | SER | 2.680 | 3.708 | -1.028 | 1.028 |
| 83 | GLY | 94 | ALA | 0.000 | 1.028 | -1.028 | 1.028 |
| 321 | MET | 325 | LYS | 1.027 | 0.000 | 1.027 | 1.027 |
| 286 | ARG | 289 | GLU | 0.000 | 1.021 | -1.021 | 1.021 |
| 288 | LEU | 336 | ARG | 1.018 | 0.000 | 1.018 | 1.018 |
| 145 | LEU | 150 | LEU | 4.081 | 3.069 | 1.012 | 1.012 |
| 227 | VAL | 258 | SER | 1.011 | 0.000 | 1.011 | 1.011 |
| 194 | ARG | 204 | TYR | 0.000 | 1.011 | -1.011 | 1.011 |
| 162 | TRP | 164 | PHE | 3.184 | 4.192 | -1.008 | 1.008 |
| 399 | PRO | 413 | PHE | 0.000 | 1.006 | -1.006 | 1.006 |
| 406 | SER | 409 | PHE | 1.715 | 2.719 | -1.004 | 1.004 |
| 450 | ALA | 451 | PRO | 1.279 | 0.275 | 1.004 | 1.004 |
| 281 | ALA | 343 | GLU | 1.000 | 0.000 | 1.000 | 1.000 |
| 479 | GLU | 481 | GLN | 0.000 | 0.998 | -0.998 | 0.998 |
| 187 | LEU | 354 | VAL | 0.000 | 0.990 | -0.990 | 0.990 |
| 277 | VAL | 350 | LEU | 0.981 | 0.000 | 0.981 | 0.981 |
| 487 | ARG | 488 | ARG | 0.975 | 0.000 | 0.975 | 0.975 |
| 335 | VAL | 339 | LYS | 0.000 | 0.964 | -0.964 | 0.964 |
| 250 | GLU | 372 | SER | 4.111 | 3.150 | 0.962 | 0.962 |
| 166 | ARG | 242 | ASP | 0.000 | 0.935 | -0.935 | 0.935 |
| 191 | SER | 270 | ILE | 3.014 | 2.088 | 0.926 | 0.926 |
| 398 | ASN | 403 | PRO | 0.926 | 0.000 | 0.926 | 0.926 |
| 193 | ASP | 204 | TYR | 6.120 | 7.043 | -0.923 | 0.923 |
| 182 | ALA | 220 | LEU | 1.436 | 2.356 | -0.920 | 0.920 |
| 121 | VAL | 409 | PHE | 1.621 | 0.704 | 0.917 | 0.917 |
| 236 | LYS | 239 | VAL | 0.914 | 0.000 | 0.914 | 0.914 |
| 166 | ARG | 241 | PRO | 0.000 | 0.911 | -0.911 | 0.911 |
| 155 | THR | 164 | PHE | 1.084 | 1.989 | -0.906 | 0.906 |
| 309 | ARG | 330 | ARG | 0.000 | 0.905 | -0.905 | 0.905 |
| 117 | VAL | 409 | PHE | 0.903 | 0.000 | 0.903 | 0.903 |
| 157 | GLU | 385 | LYS | 8.150 | 9.051 | -0.901 | 0.901 |
| 120 | SER | 409 | PHE | 0.981 | 1.870 | -0.889 | 0.889 |
| 152 | PHE | 168 | PHE | 5.351 | 6.238 | -0.887 | 0.887 |
| 356 | VAL | 401 | ILE | 1.495 | 0.618 | 0.877 | 0.877 |
| 474 | PRO | 475 | PRO | 3.580 | 2.704 | 0.876 | 0.876 |
| 141 | ALA | 221 | TRP | 2.106 | 1.230 | 0.876 | 0.876 |
| 156 | MET | 162 | TRP | 1.595 | 2.470 | -0.875 | 0.875 |
| 318 | ALA | 322 | ARG | 0.863 | 0.000 | 0.863 | 0.863 |
| 120 | SER | 413 | PHE | 1.279 | 2.139 | -0.860 | 0.860 |
| 36 | ALA | 37 | PRO | 0.880 | 0.024 | 0.856 | 0.856 |
| 103 | LEU | 389 | TRP | 3.984 | 4.833 | -0.849 | 0.849 |
| 258 | SER | 262 | SER | 0.000 | 0.848 | -0.848 | 0.848 |
| 116 | LEU | 416 | LEU | 0.538 | 1.381 | -0.842 | 0.842 |
| 135 | ILE | 350 | LEU | 0.000 | 0.841 | -0.841 | 0.841 |
| 284 | THR | 339 | LYS | 0.833 | 0.000 | 0.833 | 0.833 |
| 135 | ILE | 190 | ILE | 1.104 | 0.271 | 0.833 | 0.833 |
| 182 | ALA | 221 | TRP | 3.274 | 2.449 | 0.825 | 0.825 |
| 3 | PHE | 386 | VAL | 0.000 | 0.825 | -0.825 | 0.825 |
| 195 | TYR | 276 | ARG | 4.618 | 3.796 | 0.822 | 0.822 |
| 263 | PHE | 267 | MET | 2.802 | 1.980 | 0.822 | 0.822 |
| 235 | TRP | 249 | THR | 1.597 | 0.775 | 0.822 | 0.822 |
| 338 | LEU | 564 | TYR | 0.000 | 0.821 | -0.821 | 0.821 |
| 473 | GLU | 474 | PRO | 5.883 | 5.063 | 0.820 | 0.820 |
| 192 | VAL | 273 | MET | 0.824 | 1.644 | -0.820 | 0.820 |
| 352 | ILE | 401 | ILE | 0.525 | 1.338 | -0.813 | 0.813 |
| 388 | PHE | 392 | TYR | 6.863 | 7.671 | -0.808 | 0.808 |
| 156 | MET | 172 | TRP | 0.138 | 0.946 | -0.808 | 0.808 |
| 301 | GLU | 303 | VAL | 0.000 | 0.804 | -0.804 | 0.804 |
| 111 | VAL | 146 | SER | 4.863 | 4.061 | 0.802 | 0.802 |
| 194 | ARG | 346 | ALA | 0.000 | 0.799 | -0.799 | 0.799 |
| 236 | LYS | 237 | GLU | 0.000 | 0.799 | -0.799 | 0.799 |
| 177 | VAL | 228 | SER | 2.313 | 1.517 | 0.796 | 0.796 |
| 278 | TYR | 347 | ALA | 0.786 | 0.000 | 0.786 | 0.786 |
| 137 | ASN | 221 | TRP | 5.651 | 4.879 | 0.771 | 0.771 |
| 130 | VAL | 134 | PHE | 0.963 | 0.192 | 0.771 | 0.771 |
| 361 | TRP | 364 | PHE | 0.000 | 0.770 | -0.770 | 0.770 |
| 398 | ASN | 402 | TYR | 1.165 | 0.399 | 0.766 | 0.766 |
| 568 | ARG | 570 | THR | 0.764 | 0.000 | 0.764 | 0.764 |
| 166 | ARG | 243 | GLU | 3.907 | 3.144 | 0.763 | 0.763 |
| 121 | VAL | 132 | ASN | 0.121 | 0.881 | -0.760 | 0.760 |
| 4 | ARG | 93 | SER | 0.000 | 0.759 | -0.759 | 0.759 |
| 287 | SER | 293 | LYS | 0.000 | 0.758 | -0.758 | 0.758 |
| 303 | VAL | 307 | HIS | 0.758 | 0.000 | 0.758 | 0.758 |
| 364 | PHE | 388 | PHE | 1.565 | 0.810 | 0.755 | 0.755 |
| 471 | ASP | 472 | PRO | 1.711 | 2.466 | -0.754 | 0.754 |
| 428 | ARG | 429 | PRO | 0.831 | 0.079 | 0.751 | 0.751 |
| 274 | TYR | 402 | TYR | 0.738 | 0.000 | 0.738 | 0.738 |
| 527 | GLN | 528 | ARG | 0.737 | 0.000 | 0.737 | 0.737 |
| 356 | VAL | 397 | VAL | 0.926 | 1.663 | -0.737 | 0.737 |
| 300 | SER | 302 | VAL | 0.000 | 0.737 | -0.737 | 0.737 |
| 360 | CYS | 391 | GLY | 2.377 | 3.103 | -0.726 | 0.726 |
| 159 | LEU | 161 | PHE | 1.531 | 2.253 | -0.723 | 0.723 |
| 308 | CYS | 330 | ARG | 0.000 | 0.721 | -0.721 | 0.721 |
| 449 | CYS | 450 | ALA | 0.718 | 0.000 | 0.718 | 0.718 |
| 249 | THR | 251 | GLU | 0.632 | 1.345 | -0.712 | 0.712 |
| 263 | PHE | 361 | TRP | 2.727 | 2.016 | 0.711 | 0.711 |
| 260 | VAL | 265 | LEU | 5.329 | 6.035 | -0.706 | 0.706 |
| 130 | VAL | 204 | TYR | 0.492 | 1.197 | -0.706 | 0.706 |
| 188 | CYS | 270 | ILE | 3.179 | 3.875 | -0.695 | 0.695 |
| 477 | THR | 478 | PRO | 0.663 | 1.358 | -0.695 | 0.695 |
| 150 | LEU | 392 | TYR | 5.420 | 4.729 | 0.691 | 0.691 |
| 106 | PHE | 396 | CYS | 3.810 | 3.120 | 0.690 | 0.690 |
| 187 | LEU | 394 | ASN | 0.690 | 0.000 | 0.690 | 0.690 |
| 134 | PHE | 208 | MET | 0.973 | 1.662 | -0.689 | 0.689 |
| 194 | ARG | 347 | ALA | 0.000 | 0.686 | -0.686 | 0.686 |
| 138 | LEU | 142 | ASP | 1.433 | 2.118 | -0.685 | 0.685 |
| 551 | ALA | 552 | GLU | 0.493 | 1.175 | -0.682 | 0.682 |
| 142 | ASP | 394 | ASN | 0.000 | 0.681 | -0.681 | 0.681 |
| 261 | CYS | 266 | PRO | 2.085 | 2.765 | -0.679 | 0.679 |
| 252 | ALA | 372 | SER | 2.272 | 2.944 | -0.672 | 0.672 |
| 152 | PHE | 162 | TRP | 0.849 | 1.521 | -0.672 | 0.672 |
| 183 | SER | 398 | ASN | 0.667 | 0.000 | 0.667 | 0.667 |
| 231 | PRO | 249 | THR | 1.182 | 0.516 | 0.666 | 0.666 |
| 209 | THR | 212 | LYS | 2.494 | 1.838 | 0.657 | 0.657 |
| 194 | ARG | 353 | VAL | 0.656 | 0.000 | 0.656 | 0.656 |
| 162 | TRP | 168 | PHE | 3.103 | 3.759 | -0.656 | 0.656 |
| 291 | GLY | 306 | ILE | 0.000 | 0.649 | -0.649 | 0.649 |
| 228 | SER | 254 | TYR | 0.647 | 0.000 | 0.647 | 0.647 |
| 358 | VAL | 363 | PRO | 0.744 | 0.103 | 0.641 | 0.641 |
| 189 | THR | 220 | LEU | 1.117 | 0.476 | 0.640 | 0.640 |
| 225 | LEU | 229 | VAL | 0.637 | 0.000 | 0.637 | 0.637 |
| 445 | LEU | 446 | ARG | 0.634 | 0.000 | 0.634 | 0.634 |
| 134 | PHE | 213 | ALA | 1.883 | 2.513 | -0.630 | 0.630 |
| 134 | PHE | 190 | ILE | 2.525 | 1.895 | 0.630 | 0.630 |
| 138 | LEU | 190 | ILE | 0.793 | 0.165 | 0.628 | 0.628 |
| 187 | LEU | 353 | VAL | 0.000 | 0.621 | -0.621 | 0.621 |
| 102 | PHE | 103 | LEU | 0.190 | 0.810 | -0.620 | 0.620 |
| 31 | SER | 32 | ALA | 0.619 | 0.000 | 0.619 | 0.619 |
| 2 | THR | 382 | GLY | 0.000 | 0.616 | -0.616 | 0.616 |
| 302 | VAL | 306 | ILE | 0.616 | 0.000 | 0.616 | 0.616 |
| 491 | PRO | 492 | SER | 1.148 | 1.762 | -0.615 | 0.615 |
| 187 | LEU | 270 | ILE | 1.589 | 2.198 | -0.610 | 0.610 |
| 259 | SER | 365 | PHE | 2.794 | 2.186 | 0.608 | 0.608 |
| 312 | ALA | 313 | THR | 0.000 | 0.606 | -0.606 | 0.606 |
| 269 | VAL | 273 | MET | 0.789 | 0.182 | 0.606 | 0.606 |
| 131 | THR | 204 | TYR | 2.370 | 2.975 | -0.605 | 0.605 |
| 198 | VAL | 343 | GLU | 0.000 | 0.601 | -0.601 | 0.601 |
| 145 | LEU | 176 | ASP | 1.699 | 1.099 | 0.600 | 0.600 |
| 251 | GLU | 372 | SER | 0.000 | 0.599 | -0.599 | 0.599 |
| 274 | TYR | 347 | ALA | 0.000 | 0.598 | -0.598 | 0.598 |
| 349 | THR | 401 | ILE | 0.000 | 0.593 | -0.593 | 0.593 |
| 292 | VAL | 336 | ARG | 0.587 | 0.000 | 0.587 | 0.587 |
| 483 | PRO | 484 | VAL | 0.000 | 0.587 | -0.587 | 0.587 |
| 201 | SER | 202 | LEU | 0.352 | 0.933 | -0.581 | 0.581 |
| 229 | VAL | 233 | LEU | 0.909 | 1.488 | -0.579 | 0.579 |
| 415 | ARG | 421 | CYS | 0.000 | 0.575 | -0.575 | 0.575 |
| 329 | PHE | 333 | LEU | 0.573 | 0.000 | 0.573 | 0.573 |
| 452 | SER | 453 | SER | 1.580 | 1.007 | 0.572 | 0.572 |
| 178 | LEU | 221 | TRP | 1.383 | 0.812 | 0.571 | 0.571 |
| 534 | ALA | 535 | GLN | 0.000 | 0.570 | -0.570 | 0.570 |
| 56 | VAL | 57 | VAL | 0.363 | 0.931 | -0.568 | 0.568 |
| 149 | VAL | 392 | TYR | 0.837 | 1.403 | -0.567 | 0.567 |
| 162 | TRP | 172 | TRP | 3.957 | 3.395 | 0.562 | 0.562 |
| 132 | ASN | 135 | ILE | 0.287 | 0.847 | -0.560 | 0.560 |
| 248 | ILE | 364 | PHE | 0.090 | 0.650 | -0.560 | 0.560 |
| 292 | VAL | 337 | LEU | 0.559 | 0.000 | 0.559 | 0.559 |
| 208 | MET | 213 | ALA | 0.711 | 0.152 | 0.559 | 0.559 |
| 200 | HIS | 207 | ILE | 1.101 | 1.658 | -0.557 | 0.557 |
| 1 | MET | 5 | ASP | 0.394 | 0.950 | -0.556 | 0.556 |
| 152 | PHE | 172 | TRP | 1.491 | 0.942 | 0.549 | 0.549 |
| 278 | TYR | 350 | LEU | 0.548 | 0.000 | 0.548 | 0.548 |
| 466 | ALA | 467 | LEU | 0.000 | 0.545 | -0.545 | 0.545 |
| 190 | ILE | 274 | TYR | 1.042 | 0.498 | 0.545 | 0.545 |
| 194 | ARG | 277 | VAL | 0.915 | 1.460 | -0.545 | 0.545 |
| 364 | PHE | 368 | LEU | 1.001 | 1.545 | -0.544 | 0.544 |
| 138 | LEU | 402 | TYR | 1.302 | 0.762 | 0.540 | 0.540 |
| 127 | LEU | 409 | PHE | 1.303 | 0.766 | 0.538 | 0.538 |
| 162 | TRP | 169 | CYS | 6.506 | 5.971 | 0.535 | 0.535 |
| 137 | ASN | 186 | SER | 2.756 | 2.223 | 0.534 | 0.534 |
| 172 | TRP | 388 | PHE | 0.145 | 0.679 | -0.534 | 0.534 |
| 2 | THR | 4 | ARG | 0.881 | 1.413 | -0.533 | 0.533 |
| 306 | ILE | 333 | LEU | 0.000 | 0.531 | -0.531 | 0.531 |
| 220 | LEU | 221 | TRP | 1.799 | 1.270 | 0.529 | 0.529 |
| 192 | VAL | 269 | VAL | 0.528 | 0.000 | 0.528 | 0.528 |
| 323 | SER | 327 | HIS | 0.527 | 0.000 | 0.527 | 0.527 |
| 358 | VAL | 362 | PHE | 0.660 | 0.134 | 0.526 | 0.526 |
| 249 | THR | 254 | TYR | 2.352 | 1.826 | 0.526 | 0.526 |
| 539 | VAL | 542 | VAL | 0.526 | 0.000 | 0.526 | 0.526 |
| 185 | LEU | 266 | PRO | 0.628 | 0.103 | 0.525 | 0.525 |
| 6 | LEU | 386 | VAL | 0.000 | 0.525 | -0.525 | 0.525 |
| 345 | LYS | 404 | CYS | 0.523 | 0.000 | 0.523 | 0.523 |
| 114 | ASN | 395 | SER | 2.044 | 2.566 | -0.522 | 0.522 |
| 248 | ILE | 388 | PHE | 0.858 | 0.339 | 0.519 | 0.519 |
| 272 | VAL | 273 | MET | 0.000 | 0.519 | -0.519 | 0.519 |
| 292 | VAL | 333 | LEU | 0.513 | 0.000 | 0.513 | 0.513 |
| 329 | PHE | 332 | SER | 0.000 | 0.512 | -0.512 | 0.512 |
| 7 | LEU | 99 | VAL | 0.000 | 0.508 | -0.508 | 0.508 |
| 255 | ALA | 372 | SER | 1.484 | 0.983 | 0.501 | 0.501 |
| 332 | SER | 333 | LEU | 0.000 | 0.496 | -0.496 | 0.496 |
| 362 | PHE | 363 | PRO | 1.049 | 1.544 | -0.494 | 0.494 |
| 259 | SER | 264 | TYR | 4.664 | 5.153 | -0.490 | 0.490 |
| 564 | TYR | 567 | LEU | 0.487 | 0.000 | 0.487 | 0.487 |
| 277 | VAL | 347 | ALA | 0.000 | 0.486 | -0.486 | 0.486 |
| 195 | TYR | 277 | VAL | 2.128 | 2.614 | -0.486 | 0.486 |
| 110 | ALA | 146 | SER | 2.774 | 2.294 | 0.480 | 0.480 |
| 194 | ARG | 405 | SER | 0.477 | 0.000 | 0.477 | 0.477 |
| 117 | VAL | 399 | PRO | 0.685 | 1.153 | -0.468 | 0.468 |
| 176 | ASP | 180 | CYS | 1.550 | 1.088 | 0.462 | 0.462 |
| 429 | PRO | 431 | TRP | 0.460 | 0.000 | 0.460 | 0.460 |
| 180 | CYS | 361 | TRP | 2.577 | 2.119 | 0.459 | 0.459 |
| 571 | ASP | 572 | ILE | 0.000 | 0.456 | -0.456 | 0.456 |
| 172 | TRP | 176 | ASP | 0.451 | 0.000 | 0.451 | 0.451 |
| 130 | VAL | 209 | THR | 0.000 | 0.448 | -0.448 | 0.448 |
| 169 | CYS | 170 | ASP | 0.445 | 0.000 | 0.445 | 0.445 |
| 460 | ALA | 461 | PRO | 0.894 | 1.339 | -0.445 | 0.445 |
| 19 | SER | 20 | ALA | 0.183 | 0.623 | -0.440 | 0.440 |
| 141 | ALA | 182 | ALA | 1.153 | 0.716 | 0.436 | 0.436 |
| 153 | SER | 389 | TRP | 2.094 | 1.658 | 0.436 | 0.436 |
| 153 | SER | 388 | PHE | 0.000 | 0.435 | -0.435 | 0.435 |
| 191 | SER | 269 | VAL | 0.655 | 0.222 | 0.433 | 0.433 |
| 120 | SER | 121 | VAL | 0.000 | 0.429 | -0.429 | 0.429 |
| 227 | VAL | 261 | CYS | 0.428 | 0.000 | 0.428 | 0.428 |
| 145 | LEU | 392 | TYR | 0.802 | 1.227 | -0.425 | 0.425 |
| 331 | SER | 335 | VAL | 0.000 | 0.421 | -0.421 | 0.421 |
| 506 | PRO | 508 | THR | 0.186 | 0.604 | -0.418 | 0.418 |
| 185 | LEU | 224 | ALA | 0.593 | 0.181 | 0.412 | 0.412 |
| 361 | TRP | 365 | PHE | 1.992 | 2.405 | -0.412 | 0.412 |
| 360 | CYS | 390 | LEU | 6.633 | 7.039 | -0.406 | 0.406 |
| 177 | VAL | 227 | VAL | 0.536 | 0.941 | -0.405 | 0.405 |
| 472 | PRO | 473 | GLU | 1.255 | 0.853 | 0.402 | 0.402 |
| 183 | SER | 394 | ASN | 0.401 | 0.000 | 0.401 | 0.401 |
| 90 | LEU | 159 | LEU | 0.852 | 1.253 | -0.400 | 0.400 |
| 264 | TYR | 366 | PHE | 0.962 | 1.361 | -0.399 | 0.399 |
| 103 | LEU | 157 | GLU | 0.247 | 0.646 | -0.399 | 0.399 |
| 352 | ILE | 405 | SER | 0.000 | 0.398 | -0.398 | 0.398 |
| 270 | ILE | 274 | TYR | 1.120 | 0.724 | 0.396 | 0.396 |
| 111 | VAL | 147 | ALA | 0.713 | 0.320 | 0.393 | 0.393 |
| 306 | ILE | 308 | CYS | 0.000 | 0.391 | -0.391 | 0.391 |
| 410 | LYS | 414 | LEU | 0.765 | 0.377 | 0.388 | 0.388 |
| 250 | GLU | 255 | ALA | 0.615 | 1.003 | -0.388 | 0.388 |
| 3 | PHE | 382 | GLY | 0.000 | 0.387 | -0.387 | 0.387 |
| 127 | LEU | 132 | ASN | 5.865 | 6.250 | -0.385 | 0.385 |
| 120 | SER | 416 | LEU | 2.353 | 1.969 | 0.383 | 0.383 |
| 195 | TYR | 280 | VAL | 0.000 | 0.377 | -0.377 | 0.377 |
| 241 | PRO | 242 | ASP | 0.000 | 0.375 | -0.375 | 0.375 |
| 169 | CYS | 246 | CYS | 6.507 | 6.133 | 0.374 | 0.374 |
| 485 | ALA | 486 | SER | 0.000 | 0.371 | -0.371 | 0.371 |
| 455 | ASP | 456 | ALA | 0.368 | 0.000 | 0.368 | 0.368 |
| 198 | VAL | 340 | PHE | 0.000 | 0.368 | -0.368 | 0.368 |
| 8 | SER | 9 | VAL | 0.470 | 0.103 | 0.367 | 0.367 |
| 129 | THR | 132 | ASN | 4.034 | 3.667 | 0.367 | 0.367 |
| 172 | TRP | 392 | TYR | 0.567 | 0.200 | 0.367 | 0.367 |
| 118 | ILE | 136 | VAL | 0.212 | 0.577 | -0.365 | 0.365 |
| 292 | VAL | 296 | ARG | 0.364 | 0.000 | 0.364 | 0.364 |
| 236 | LYS | 247 | GLY | 0.000 | 0.362 | -0.362 | 0.362 |
| 284 | THR | 288 | LEU | 0.268 | 0.629 | -0.361 | 0.361 |
| 457 | PRO | 458 | PRO | 2.302 | 2.663 | -0.361 | 0.361 |
| 256 | VAL | 373 | LEU | 1.262 | 0.902 | 0.360 | 0.360 |
| 145 | LEU | 395 | SER | 1.041 | 0.683 | 0.358 | 0.358 |
| 184 | ILE | 270 | ILE | 0.231 | 0.588 | -0.357 | 0.357 |
| 96 | GLY | 158 | VAL | 1.369 | 1.012 | 0.357 | 0.357 |
| 130 | VAL | 210 | GLU | 1.007 | 0.650 | 0.357 | 0.357 |
| 371 | GLY | 378 | LYS | 0.105 | 0.460 | -0.355 | 0.355 |
| 350 | LEU | 402 | TYR | 0.000 | 0.355 | -0.355 | 0.355 |
| 140 | VAL | 144 | LEU | 0.353 | 0.000 | 0.353 | 0.353 |
| 189 | THR | 216 | ILE | 0.838 | 1.191 | -0.353 | 0.353 |
| 225 | LEU | 228 | SER | 0.649 | 0.299 | 0.349 | 0.349 |
| 283 | SER | 284 | THR | 0.348 | 0.000 | 0.348 | 0.348 |
| 124 | ASN | 412 | ALA | 1.062 | 1.407 | -0.345 | 0.345 |
| 348 | LYS | 352 | ILE | 0.000 | 0.340 | -0.340 | 0.340 |
| 149 | VAL | 175 | VAL | 1.696 | 1.364 | 0.332 | 0.332 |
| 285 | THR | 340 | PHE | 2.541 | 2.209 | 0.332 | 0.332 |
| 182 | ALA | 224 | ALA | 1.491 | 1.161 | 0.330 | 0.330 |
| 397 | VAL | 401 | ILE | 1.262 | 0.934 | 0.328 | 0.328 |
| 111 | VAL | 143 | LEU | 1.790 | 2.117 | -0.327 | 0.327 |
| 131 | THR | 350 | LEU | 0.000 | 0.326 | -0.326 | 0.326 |
| 272 | VAL | 276 | ARG | 1.684 | 1.358 | 0.326 | 0.326 |
| 500 | LEU | 503 | PHE | 0.000 | 0.326 | -0.326 | 0.326 |
| 121 | VAL | 127 | LEU | 2.488 | 2.164 | 0.324 | 0.324 |
| 174 | ALA | 228 | SER | 3.144 | 2.820 | 0.324 | 0.324 |
| 145 | LEU | 179 | CYS | 2.656 | 2.980 | -0.324 | 0.324 |
| 227 | VAL | 262 | SER | 1.121 | 0.798 | 0.323 | 0.323 |
| 267 | MET | 362 | PHE | 0.319 | 0.000 | 0.319 | 0.319 |
| 172 | TRP | 246 | CYS | 1.611 | 1.292 | 0.319 | 0.319 |
| 134 | PHE | 216 | ILE | 0.552 | 0.234 | 0.318 | 0.318 |
| 178 | LEU | 224 | ALA | 2.837 | 3.152 | -0.315 | 0.315 |
| 197 | GLY | 343 | GLU | 0.000 | 0.314 | -0.314 | 0.314 |
| 123 | CYS | 416 | LEU | 0.000 | 0.314 | -0.314 | 0.314 |
| 484 | VAL | 485 | ALA | 0.077 | 0.391 | -0.314 | 0.314 |
| 409 | PHE | 413 | PHE | 0.000 | 0.314 | -0.314 | 0.314 |
| 125 | ARG | 128 | GLN | 1.703 | 1.391 | 0.312 | 0.312 |
| 305 | ARG | 307 | HIS | 0.000 | 0.309 | -0.309 | 0.309 |
| 10 | SER | 11 | PHE | 0.309 | 0.000 | 0.309 | 0.309 |
| 162 | TRP | 245 | PHE | 0.382 | 0.073 | 0.309 | 0.309 |
| 264 | TYR | 365 | PHE | 3.186 | 2.878 | 0.309 | 0.309 |
| 231 | PRO | 254 | TYR | 5.696 | 5.390 | 0.306 | 0.306 |
| 502 | PRO | 503 | PHE | 0.000 | 0.300 | -0.300 | 0.300 |
| 248 | ILE | 368 | LEU | 0.000 | 0.298 | -0.298 | 0.298 |
| 357 | PHE | 358 | VAL | 0.297 | 0.000 | 0.297 | 0.297 |
| 197 | GLY | 204 | TYR | 3.185 | 2.890 | 0.296 | 0.296 |
| 251 | GLU | 254 | TYR | 0.504 | 0.210 | 0.294 | 0.294 |
| 186 | SER | 220 | LEU | 2.704 | 2.995 | -0.290 | 0.290 |
| 99 | VAL | 157 | GLU | 0.000 | 0.289 | -0.289 | 0.289 |
| 559 | TYR | 564 | TYR | 0.288 | 0.000 | 0.288 | 0.288 |
| 407 | ARG | 408 | GLU | 0.000 | 0.288 | -0.288 | 0.288 |
| 154 | ALA | 389 | TRP | 2.708 | 2.421 | 0.287 | 0.287 |
| 280 | VAL | 284 | THR | 0.161 | 0.448 | -0.287 | 0.287 |
| 181 | THR | 224 | ALA | 2.065 | 2.351 | -0.285 | 0.285 |
| 240 | PRO | 241 | PRO | 0.872 | 0.590 | 0.282 | 0.282 |
| 546 | VAL | 547 | PRO | 0.744 | 1.026 | -0.282 | 0.282 |
| 121 | VAL | 128 | GLN | 1.914 | 2.195 | -0.282 | 0.282 |
| 530 | GLU | 531 | ALA | 0.281 | 0.000 | 0.281 | 0.281 |
| 138 | LEU | 353 | VAL | 0.000 | 0.280 | -0.280 | 0.280 |
| 161 | PHE | 244 | ARG | 1.768 | 2.047 | -0.279 | 0.279 |
| 196 | VAL | 204 | TYR | 1.096 | 0.818 | 0.278 | 0.278 |
| 430 | LEU | 433 | VAL | 0.000 | 0.277 | -0.277 | 0.277 |
| 345 | LYS | 405 | SER | 0.107 | 0.383 | -0.277 | 0.277 |
| 368 | LEU | 369 | PRO | 1.404 | 1.679 | -0.274 | 0.274 |
| 174 | ALA | 232 | LEU | 0.607 | 0.879 | -0.272 | 0.272 |
| 204 | TYR | 205 | PRO | 1.521 | 1.789 | -0.267 | 0.267 |
| 263 | PHE | 358 | VAL | 0.000 | 0.267 | -0.267 | 0.267 |
| 118 | ILE | 139 | ALA | 1.622 | 1.888 | -0.266 | 0.266 |
| 156 | MET | 161 | PHE | 3.094 | 2.831 | 0.262 | 0.262 |
| 256 | VAL | 369 | PRO | 0.702 | 0.440 | 0.262 | 0.262 |
| 110 | ALA | 395 | SER | 0.734 | 0.994 | -0.261 | 0.261 |
| 238 | PRO | 251 | GLU | 0.000 | 0.256 | -0.256 | 0.256 |
| 360 | CYS | 361 | TRP | 0.553 | 0.296 | 0.256 | 0.256 |
| 148 | THR | 175 | VAL | 0.688 | 0.944 | -0.256 | 0.256 |
| 115 | LEU | 143 | LEU | 1.888 | 1.634 | 0.254 | 0.254 |
| 41 | PRO | 42 | ALA | 0.450 | 0.196 | 0.254 | 0.254 |
| 1 | MET | 380 | SER | 0.000 | 0.252 | -0.252 | 0.252 |
| 230 | GLY | 254 | TYR | 0.798 | 0.546 | 0.252 | 0.252 |
| 164 | PHE | 168 | PHE | 3.099 | 2.851 | 0.248 | 0.248 |
| 264 | TYR | 369 | PRO | 0.288 | 0.041 | 0.247 | 0.247 |
| 198 | VAL | 280 | VAL | 1.509 | 1.265 | 0.244 | 0.244 |
| 191 | SER | 277 | VAL | 0.000 | 0.241 | -0.241 | 0.241 |
| 517 | LEU | 521 | ILE | 0.237 | 0.000 | 0.237 | 0.237 |
| 172 | TRP | 173 | ALA | 0.822 | 0.585 | 0.237 | 0.237 |
| 199 | ARG | 200 | HIS | 5.411 | 5.646 | -0.235 | 0.235 |
| 367 | VAL | 379 | PRO | 1.448 | 1.683 | -0.234 | 0.234 |
| 462 | LEU | 463 | ALA | 1.049 | 1.283 | -0.234 | 0.234 |
| 303 | VAL | 305 | ARG | 0.000 | 0.232 | -0.232 | 0.232 |
| 292 | VAL | 294 | ARG | 0.000 | 0.230 | -0.230 | 0.230 |
| 288 | LEU | 340 | PHE | 1.072 | 0.844 | 0.229 | 0.229 |
| 118 | ILE | 143 | LEU | 0.826 | 0.598 | 0.228 | 0.228 |
| 116 | LEU | 417 | LEU | 0.599 | 0.371 | 0.228 | 0.228 |
| 263 | PHE | 264 | TYR | 1.851 | 1.624 | 0.227 | 0.227 |
| 180 | CYS | 392 | TYR | 0.225 | 0.000 | 0.225 | 0.225 |
| 345 | LYS | 349 | THR | 0.222 | 0.000 | 0.222 | 0.222 |
| 236 | LYS | 251 | GLU | 1.861 | 2.081 | -0.220 | 0.220 |
| 170 | ASP | 232 | LEU | 1.048 | 1.266 | -0.218 | 0.218 |
| 463 | ALA | 464 | LEU | 0.854 | 0.637 | 0.217 | 0.217 |
| 124 | ASN | 127 | LEU | 0.981 | 1.198 | -0.217 | 0.217 |
| 120 | SER | 412 | ALA | 0.803 | 1.018 | -0.215 | 0.215 |
| 366 | PHE | 370 | LEU | 1.120 | 0.908 | 0.212 | 0.212 |
| 349 | THR | 353 | VAL | 0.211 | 0.000 | 0.211 | 0.211 |
| 381 | GLU | 385 | LYS | 4.399 | 4.608 | -0.210 | 0.210 |
| 196 | VAL | 207 | ILE | 0.922 | 0.713 | 0.209 | 0.209 |
| 198 | VAL | 347 | ALA | 0.000 | 0.208 | -0.208 | 0.208 |
| 114 | ASN | 146 | SER | 0.206 | 0.000 | 0.206 | 0.206 |
| 489 | LYS | 490 | PRO | 0.365 | 0.160 | 0.205 | 0.205 |
| 195 | TYR | 196 | VAL | 0.223 | 0.020 | 0.203 | 0.203 |
| 560 | GLU | 562 | ALA | 0.000 | 0.202 | -0.202 | 0.202 |
| 535 | GLN | 536 | ARG | 0.000 | 0.200 | -0.200 | 0.200 |
| 360 | CYS | 393 | PHE | 0.417 | 0.219 | 0.199 | 0.199 |
| 172 | TRP | 248 | ILE | 0.000 | 0.197 | -0.197 | 0.197 |
| 107 | ILE | 150 | LEU | 3.417 | 3.220 | 0.196 | 0.196 |
| 185 | LEU | 223 | VAL | 0.745 | 0.935 | -0.190 | 0.190 |
| 380 | SER | 383 | VAL | 1.334 | 1.145 | 0.188 | 0.188 |
| 126 | HIS | 342 | ARG | 0.000 | 0.188 | -0.188 | 0.188 |
| 198 | VAL | 277 | VAL | 0.456 | 0.640 | -0.184 | 0.184 |
| 217 | LEU | 220 | LEU | 0.068 | 0.251 | -0.183 | 0.183 |
| 260 | VAL | 266 | PRO | 0.338 | 0.518 | -0.180 | 0.180 |
| 141 | ALA | 179 | CYS | 1.389 | 1.212 | 0.177 | 0.177 |
| 100 | GLY | 158 | VAL | 1.481 | 1.306 | 0.175 | 0.175 |
| 187 | LEU | 190 | ILE | 0.000 | 0.174 | -0.174 | 0.174 |
| 130 | VAL | 208 | MET | 1.087 | 1.258 | -0.171 | 0.171 |
| 349 | THR | 402 | TYR | 0.000 | 0.170 | -0.170 | 0.170 |
| 208 | MET | 216 | ILE | 0.744 | 0.574 | 0.170 | 0.170 |
| 304 | LEU | 308 | CYS | 0.170 | 0.000 | 0.170 | 0.170 |
| 258 | SER | 259 | SER | 0.166 | 0.000 | 0.166 | 0.166 |
| 151 | PRO | 152 | PHE | 0.000 | 0.165 | -0.165 | 0.165 |
| 144 | LEU | 221 | TRP | 0.527 | 0.363 | 0.163 | 0.163 |
| 146 | SER | 150 | LEU | 0.626 | 0.788 | -0.163 | 0.163 |
| 271 | VAL | 354 | VAL | 0.162 | 0.000 | 0.162 | 0.162 |
| 187 | LEU | 361 | TRP | 0.160 | 0.000 | 0.160 | 0.160 |
| 255 | ALA | 369 | PRO | 0.283 | 0.127 | 0.156 | 0.156 |
| 176 | ASP | 248 | ILE | 0.000 | 0.156 | -0.156 | 0.156 |
| 110 | ALA | 396 | CYS | 2.479 | 2.324 | 0.155 | 0.155 |
| 367 | VAL | 384 | PHE | 0.690 | 0.535 | 0.155 | 0.155 |
| 428 | ARG | 432 | ARG | 0.153 | 0.000 | 0.153 | 0.153 |
| 146 | SER | 151 | PRO | 1.389 | 1.540 | -0.151 | 0.151 |
| 111 | VAL | 115 | LEU | 0.758 | 0.608 | 0.150 | 0.150 |
| 144 | LEU | 149 | VAL | 0.500 | 0.350 | 0.150 | 0.150 |
| 169 | CYS | 247 | GLY | 0.657 | 0.508 | 0.149 | 0.149 |
| 107 | ILE | 146 | SER | 0.912 | 0.763 | 0.149 | 0.149 |
| 350 | LEU | 353 | VAL | 0.000 | 0.146 | -0.146 | 0.146 |
| 481 | GLN | 482 | ALA | 0.945 | 1.091 | -0.146 | 0.146 |
| 258 | SER | 263 | PHE | 0.161 | 0.307 | -0.146 | 0.146 |
| 228 | SER | 229 | VAL | 0.352 | 0.206 | 0.146 | 0.146 |
| 393 | PHE | 397 | VAL | 2.191 | 2.336 | -0.145 | 0.145 |
| 289 | GLU | 570 | THR | 0.000 | 0.143 | -0.143 | 0.143 |
| 106 | PHE | 389 | TRP | 1.666 | 1.523 | 0.142 | 0.142 |
| 565 | SER | 566 | ASN | 1.376 | 1.236 | 0.141 | 0.141 |
| 304 | LEU | 306 | ILE | 0.000 | 0.136 | -0.136 | 0.136 |
| 137 | ASN | 182 | ALA | 0.000 | 0.134 | -0.134 | 0.134 |
| 192 | VAL | 196 | VAL | 0.235 | 0.102 | 0.133 | 0.133 |
| 340 | PHE | 344 | LYS | 0.130 | 0.264 | -0.133 | 0.133 |
| 267 | MET | 271 | VAL | 0.147 | 0.279 | -0.132 | 0.132 |
| 412 | ALA | 415 | ARG | 0.399 | 0.531 | -0.132 | 0.132 |
| 99 | VAL | 158 | VAL | 0.039 | 0.170 | -0.132 | 0.132 |
| 107 | ILE | 151 | PRO | 1.296 | 1.427 | -0.131 | 0.131 |
| 352 | ILE | 356 | VAL | 0.168 | 0.040 | 0.129 | 0.129 |
| 349 | THR | 350 | LEU | 0.000 | 0.127 | -0.127 | 0.127 |
| 411 | ARG | 415 | ARG | 0.301 | 0.177 | 0.124 | 0.124 |
| 364 | PHE | 384 | PHE | 0.163 | 0.285 | -0.123 | 0.123 |
| 162 | TRP | 246 | CYS | 7.068 | 6.947 | 0.121 | 0.121 |
| 131 | THR | 193 | ASP | 5.228 | 5.346 | -0.117 | 0.117 |
| 204 | TYR | 208 | MET | 3.090 | 3.206 | -0.116 | 0.116 |
| 90 | LEU | 92 | VAL | 1.187 | 1.303 | -0.116 | 0.116 |
| 117 | VAL | 135 | ILE | 0.734 | 0.849 | -0.115 | 0.115 |
| 123 | CYS | 124 | ASN | 0.506 | 0.391 | 0.115 | 0.115 |
| 133 | TYR | 217 | LEU | 0.338 | 0.453 | -0.115 | 0.115 |
| 8 | SER | 12 | GLU | 0.000 | 0.115 | -0.115 | 0.115 |
| 106 | PHE | 109 | MET | 0.000 | 0.115 | -0.115 | 0.115 |
| 119 | LEU | 124 | ASN | 0.110 | 0.000 | 0.110 | 0.110 |
| 113 | GLY | 413 | PHE | 0.000 | 0.109 | -0.109 | 0.109 |
| 357 | PHE | 362 | PHE | 0.164 | 0.056 | 0.107 | 0.107 |
| 235 | TRP | 257 | PHE | 0.285 | 0.181 | 0.104 | 0.104 |
| 304 | LEU | 333 | LEU | 0.000 | 0.104 | -0.104 | 0.104 |
| 120 | SER | 127 | LEU | 1.527 | 1.424 | 0.103 | 0.103 |
| 166 | ARG | 169 | CYS | 0.102 | 0.000 | 0.102 | 0.102 |
| 222 | VAL | 226 | VAL | 0.100 | 0.000 | 0.100 | 0.100 |
| 183 | SER | 357 | PHE | 0.000 | 0.100 | -0.100 | 0.100 |
| 148 | THR | 149 | VAL | 0.473 | 0.374 | 0.099 | 0.099 |
| 482 | ALA | 483 | PRO | 0.782 | 0.880 | -0.098 | 0.098 |
| 263 | PHE | 365 | PHE | 11.636 | 11.538 | 0.098 | 0.098 |
| 155 | THR | 159 | LEU | 0.962 | 1.060 | -0.098 | 0.098 |
| 363 | PRO | 390 | LEU | 0.520 | 0.424 | 0.097 | 0.097 |
| 266 | PRO | 270 | ILE | 0.096 | 0.000 | 0.096 | 0.096 |
| 292 | VAL | 304 | LEU | 0.000 | 0.096 | -0.096 | 0.096 |
| 196 | VAL | 201 | SER | 0.352 | 0.256 | 0.095 | 0.095 |
| 121 | VAL | 133 | TYR | 0.095 | 0.000 | 0.095 | 0.095 |
| 103 | LEU | 154 | ALA | 1.977 | 1.885 | 0.092 | 0.092 |
| 3 | PHE | 102 | PHE | 0.000 | 0.091 | -0.091 | 0.091 |
| 278 | TYR | 279 | VAL | 0.000 | 0.089 | -0.089 | 0.089 |
| 2 | THR | 5 | ASP | 5.088 | 5.177 | -0.089 | 0.089 |
| 378 | LYS | 379 | PRO | 0.953 | 0.865 | 0.088 | 0.088 |
| 181 | THR | 185 | LEU | 0.825 | 0.913 | -0.088 | 0.088 |
| 356 | VAL | 394 | ASN | 0.342 | 0.255 | 0.087 | 0.087 |
| 24 | SER | 25 | ALA | 0.835 | 0.922 | -0.087 | 0.087 |
| 136 | VAL | 140 | VAL | 0.207 | 0.121 | 0.086 | 0.086 |
| 379 | PRO | 384 | PHE | 0.000 | 0.086 | -0.086 | 0.086 |
| 195 | TYR | 199 | ARG | 6.047 | 5.962 | 0.085 | 0.085 |
| 126 | HIS | 408 | GLU | 0.085 | 0.000 | 0.085 | 0.085 |
| 360 | CYS | 387 | ILE | 0.000 | 0.085 | -0.085 | 0.085 |
| 294 | ARG | 298 | LYS | 0.084 | 0.000 | 0.084 | 0.084 |
| 177 | VAL | 254 | TYR | 1.046 | 0.963 | 0.083 | 0.083 |
| 187 | LEU | 274 | TYR | 0.082 | 0.000 | 0.082 | 0.082 |
| 252 | ALA | 373 | LEU | 0.145 | 0.225 | -0.080 | 0.080 |
| 256 | VAL | 260 | VAL | 0.156 | 0.236 | -0.080 | 0.080 |
| 143 | LEU | 147 | ALA | 0.080 | 0.000 | 0.080 | 0.080 |
| 114 | ASN | 399 | PRO | 5.267 | 5.188 | 0.079 | 0.079 |
| 379 | PRO | 383 | VAL | 0.846 | 0.925 | -0.079 | 0.079 |
| 398 | ASN | 401 | ILE | 0.000 | 0.078 | -0.078 | 0.078 |
| 566 | ASN | 571 | ASP | 0.078 | 0.000 | 0.078 | 0.078 |
| 184 | ILE | 262 | SER | 3.125 | 3.048 | 0.077 | 0.077 |
| 250 | GLU | 378 | LYS | 5.161 | 5.237 | -0.077 | 0.077 |
| 97 | VAL | 101 | VAL | 0.041 | 0.118 | -0.077 | 0.077 |
| 370 | LEU | 374 | PHE | 0.552 | 0.477 | 0.075 | 0.075 |
| 148 | THR | 172 | TRP | 0.072 | 0.145 | -0.073 | 0.073 |
| 364 | PHE | 387 | ILE | 2.905 | 2.833 | 0.073 | 0.073 |
| 186 | SER | 189 | THR | 0.072 | 0.000 | 0.072 | 0.072 |
| 363 | PRO | 387 | ILE | 3.151 | 3.079 | 0.072 | 0.072 |
| 274 | TYR | 354 | VAL | 1.833 | 1.904 | -0.071 | 0.071 |
| 185 | LEU | 261 | CYS | 0.071 | 0.000 | 0.071 | 0.071 |
| 110 | ALA | 114 | ASN | 0.071 | 0.000 | 0.071 | 0.071 |
| 234 | GLY | 251 | GLU | 0.070 | 0.000 | 0.070 | 0.070 |
| 219 | LEU | 223 | VAL | 0.264 | 0.332 | -0.068 | 0.068 |
| 121 | VAL | 136 | VAL | 1.726 | 1.790 | -0.065 | 0.065 |
| 131 | THR | 132 | ASN | 0.223 | 0.286 | -0.063 | 0.063 |
| 129 | THR | 131 | THR | 0.111 | 0.174 | -0.063 | 0.063 |
| 440 | ALA | 441 | SER | 0.063 | 0.000 | 0.063 | 0.063 |
| 163 | ALA | 164 | PHE | 0.195 | 0.132 | 0.063 | 0.063 |
| 15 | ARG | 16 | PRO | 0.503 | 0.566 | -0.062 | 0.062 |
| 114 | ASN | 117 | VAL | 0.000 | 0.062 | -0.062 | 0.062 |
| 259 | SER | 368 | LEU | 0.750 | 0.689 | 0.061 | 0.061 |
| 35 | ALA | 36 | ALA | 0.061 | 0.000 | 0.061 | 0.061 |
| 441 | SER | 442 | THR | 0.061 | 0.000 | 0.061 | 0.061 |
| 373 | LEU | 374 | PHE | 1.401 | 1.341 | 0.060 | 0.060 |
| 71 | GLU | 72 | PRO | 1.662 | 1.721 | -0.059 | 0.059 |
| 561 | LEU | 564 | TYR | 0.059 | 0.000 | 0.059 | 0.059 |
| 208 | MET | 212 | LYS | 0.000 | 0.058 | -0.058 | 0.058 |
| 196 | VAL | 200 | HIS | 0.010 | 0.066 | -0.056 | 0.056 |
| 106 | PHE | 392 | TYR | 1.817 | 1.761 | 0.055 | 0.055 |
| 259 | SER | 369 | PRO | 1.922 | 1.867 | 0.055 | 0.055 |
| 283 | SER | 287 | SER | 0.000 | 0.055 | -0.055 | 0.055 |
| 271 | VAL | 275 | CYS | 0.372 | 0.318 | 0.054 | 0.054 |
| 402 | TYR | 403 | PRO | 0.854 | 0.801 | 0.053 | 0.053 |
| 150 | LEU | 389 | TRP | 0.447 | 0.499 | -0.052 | 0.052 |
| 159 | LEU | 163 | ALA | 0.601 | 0.652 | -0.052 | 0.052 |
| 185 | LEU | 188 | CYS | 0.000 | 0.052 | -0.052 | 0.052 |
| 184 | ILE | 185 | LEU | 0.000 | 0.051 | -0.051 | 0.051 |
| 183 | SER | 395 | SER | 0.051 | 0.000 | 0.051 | 0.051 |
| 193 | ASP | 208 | MET | 1.182 | 1.232 | -0.050 | 0.050 |
| 408 | GLU | 415 | ARG | 0.049 | 0.000 | 0.049 | 0.049 |
| 542 | VAL | 544 | LEU | 0.000 | 0.049 | -0.049 | 0.049 |
| 370 | LEU | 377 | LEU | 1.416 | 1.464 | -0.048 | 0.048 |
| 153 | SER | 172 | TRP | 3.819 | 3.867 | -0.048 | 0.048 |
| 4 | ARG | 5 | ASP | 0.334 | 0.381 | -0.047 | 0.047 |
| 177 | VAL | 258 | SER | 0.000 | 0.047 | -0.047 | 0.047 |
| 127 | LEU | 412 | ALA | 0.687 | 0.640 | 0.047 | 0.047 |
| 356 | VAL | 360 | CYS | 0.386 | 0.340 | 0.047 | 0.047 |
| 145 | LEU | 151 | PRO | 0.076 | 0.029 | 0.046 | 0.046 |
| 107 | ILE | 154 | ALA | 0.581 | 0.535 | 0.046 | 0.046 |
| 134 | PHE | 186 | SER | 0.000 | 0.045 | -0.045 | 0.045 |
| 274 | TYR | 277 | VAL | 0.000 | 0.045 | -0.045 | 0.045 |
| 461 | PRO | 462 | LEU | 1.476 | 1.434 | 0.042 | 0.042 |
| 92 | VAL | 158 | VAL | 0.107 | 0.148 | -0.042 | 0.042 |
| 354 | VAL | 358 | VAL | 0.212 | 0.170 | 0.041 | 0.041 |
| 263 | PHE | 362 | PHE | 3.902 | 3.862 | 0.040 | 0.040 |
| 398 | ASN | 399 | PRO | 0.940 | 0.980 | -0.040 | 0.040 |
| 505 | ARG | 506 | PRO | 0.379 | 0.419 | -0.040 | 0.040 |
| 149 | VAL | 172 | TRP | 4.903 | 4.942 | -0.039 | 0.039 |
| 143 | LEU | 146 | SER | 0.198 | 0.237 | -0.039 | 0.039 |
| 401 | ILE | 405 | SER | 0.093 | 0.054 | 0.038 | 0.038 |
| 137 | ASN | 220 | LEU | 0.909 | 0.872 | 0.037 | 0.037 |
| 149 | VAL | 153 | SER | 0.610 | 0.647 | -0.037 | 0.037 |
| 63 | GLU | 64 | ASP | 0.037 | 0.000 | 0.037 | 0.037 |
| 254 | TYR | 259 | SER | 0.052 | 0.088 | -0.036 | 0.036 |
| 142 | ASP | 183 | SER | 3.159 | 3.123 | 0.035 | 0.035 |
| 191 | SER | 192 | VAL | 0.349 | 0.313 | 0.035 | 0.035 |
| 550 | VAL | 551 | ALA | 0.000 | 0.035 | -0.035 | 0.035 |
| 99 | VAL | 103 | LEU | 0.958 | 0.992 | -0.034 | 0.034 |
| 374 | PHE | 377 | LEU | 1.554 | 1.520 | 0.034 | 0.034 |
| 200 | HIS | 203 | LYS | 0.105 | 0.138 | -0.033 | 0.033 |
| 177 | VAL | 181 | THR | 0.477 | 0.444 | 0.033 | 0.033 |
| 203 | LYS | 207 | ILE | 0.904 | 0.937 | -0.033 | 0.033 |
| 366 | PHE | 367 | VAL | 0.125 | 0.093 | 0.033 | 0.033 |
| 201 | SER | 343 | GLU | 0.000 | 0.030 | -0.030 | 0.030 |
| 262 | SER | 365 | PHE | 0.553 | 0.523 | 0.030 | 0.030 |
| 383 | VAL | 387 | ILE | 0.573 | 0.543 | 0.029 | 0.029 |
| 342 | ARG | 407 | ARG | 0.028 | 0.000 | 0.028 | 0.028 |
| 161 | PHE | 163 | ALA | 0.581 | 0.554 | 0.027 | 0.027 |
| 169 | CYS | 245 | PHE | 0.024 | 0.000 | 0.024 | 0.024 |
| 237 | GLU | 238 | PRO | 0.971 | 0.993 | -0.022 | 0.022 |
| 92 | VAL | 97 | VAL | 1.592 | 1.570 | 0.022 | 0.022 |
| 130 | VAL | 213 | ALA | 0.909 | 0.888 | 0.020 | 0.020 |
| 134 | PHE | 217 | LEU | 2.203 | 2.223 | -0.020 | 0.020 |
| 140 | VAL | 221 | TRP | 0.158 | 0.177 | -0.019 | 0.019 |
| 260 | VAL | 264 | TYR | 0.185 | 0.166 | 0.019 | 0.019 |
| 229 | VAL | 232 | LEU | 0.019 | 0.000 | 0.019 | 0.019 |
| 265 | LEU | 266 | PRO | 0.910 | 0.929 | -0.019 | 0.019 |
| 145 | LEU | 149 | VAL | 1.457 | 1.475 | -0.019 | 0.019 |
| 110 | ALA | 150 | LEU | 0.000 | 0.018 | -0.018 | 0.018 |
| 108 | LEU | 113 | GLY | 0.000 | 0.017 | -0.017 | 0.017 |
| 175 | VAL | 179 | CYS | 0.458 | 0.441 | 0.017 | 0.017 |
| 1 | MET | 383 | VAL | 0.000 | 0.016 | -0.016 | 0.016 |
| 150 | LEU | 151 | PRO | 0.719 | 0.734 | -0.015 | 0.015 |
| 107 | ILE | 111 | VAL | 0.194 | 0.208 | -0.014 | 0.014 |
| 490 | PRO | 491 | PRO | 0.841 | 0.854 | -0.013 | 0.013 |
| 402 | TYR | 410 | LYS | 0.000 | 0.013 | -0.013 | 0.013 |
| 106 | PHE | 393 | PHE | 3.037 | 3.050 | -0.013 | 0.013 |
| 295 | GLU | 333 | LEU | 0.011 | 0.000 | 0.011 | 0.011 |
| 209 | THR | 211 | ARG | 0.257 | 0.246 | 0.010 | 0.010 |
| 106 | PHE | 107 | ILE | 0.176 | 0.166 | 0.010 | 0.010 |
| 261 | CYS | 262 | SER | 0.030 | 0.021 | 0.009 | 0.009 |
| 117 | VAL | 139 | ALA | 1.173 | 1.182 | -0.009 | 0.009 |
| 188 | CYS | 191 | SER | 0.009 | 0.000 | 0.009 | 0.009 |
| 171 | VAL | 175 | VAL | 0.244 | 0.252 | -0.008 | 0.008 |
| 106 | PHE | 150 | LEU | 0.541 | 0.533 | 0.007 | 0.007 |
| 84 | THR | 91 | VAL | 0.031 | 0.038 | -0.007 | 0.007 |
| 342 | ARG | 408 | GLU | 0.000 | 0.005 | -0.005 | 0.005 |
| 118 | ILE | 140 | VAL | 1.257 | 1.262 | -0.004 | 0.004 |
| 353 | VAL | 402 | TYR | 1.476 | 1.480 | -0.004 | 0.004 |
| 374 | PHE | 375 | PRO | 0.141 | 0.138 | 0.004 | 0.004 |
| 135 | ILE | 409 | PHE | 0.572 | 0.575 | -0.003 | 0.003 |
| 257 | PHE | 261 | CYS | 1.720 | 1.722 | -0.003 | 0.003 |
| 147 | ALA | 148 | THR | 0.191 | 0.188 | 0.003 | 0.003 |
| 202 | LEU | 339 | LYS | 0.000 | 0.003 | -0.003 | 0.003 |
| 364 | PHE | 369 | PRO | 0.135 | 0.137 | -0.002 | 0.002 |
| 367 | VAL | 387 | ILE | 0.668 | 0.666 | 0.002 | 0.002 |
| 437 | HIS | 441 | SER | 0.000 | 0.001 | -0.001 | 0.001 |
| 184 | ILE | 267 | MET | 0.000 | 0.000 | -0.000 | 0.000 |
RRCS change distribution
0.02
Mean ΔRRCS
1.70
Std Dev
-0.00
Median
Magnitude classification
21
High (|Δ| ≥ 5.0)
57
Medium (2.4 ≤ |Δ| < 5.0)
681
Low (|Δ| < 2.4)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.36, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar