ADA2C
723
Total Contact Pairs
80
Significant Changes
10.19
Max Increase
-8.90
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | HIS450 (8.56x56) | ARG454 | 15.830 | 5.638 | +10.193 | HIGH |
| 2 | PRO42 | TYR199 | 0.000 | 8.902 | -8.902 | HIGH |
| 3 | TRP395 (6.48x48) | GLY426 (7.42x41) | 3.029 | 11.224 | -8.196 | HIGH |
| 4 | PHE107 (2.60x59) | TRP123 (3.24x24) | 0.000 | 7.613 | -7.613 | HIGH |
| 5 | GLU284 | ARG454 | 0.000 | 7.601 | -7.601 | HIGH |
| 6 | LEU190 | ASN205 | 7.209 | 0.000 | +7.209 | HIGH |
| 7 | TYR191 | PRO200 | 7.044 | 0.000 | +7.044 | HIGH |
| 8 | ASP148 (3.49x49) | ARG149 (3.50x50) | 0.000 | 6.843 | -6.843 | HIGH |
| 9 | ARG192 | GLN201 | 6.231 | 0.000 | +6.231 | HIGH |
| 10 | PHE391 (6.44x44) | TRP395 (6.48x48) | 1.906 | 7.986 | -6.080 | HIGH |
| 11 | TYR191 | GLY203 (45.51x51) | 0.000 | 5.925 | -5.925 | HIGH |
| 12 | PHE391 (6.44x44) | ASN429 (7.45x45) | 0.413 | 6.141 | -5.728 | HIGH |
| 13 | ARG149 (3.50x50) | SER152 (3.53x53) | 0.000 | 5.451 | -5.451 | HIGH |
| 14 | ARG192 | ASP206 | 5.114 | 0.000 | +5.114 | HIGH |
| 15 | VAL383 (6.36x36) | PHE440 (7.56x56) | 7.482 | 2.516 | +4.966 | MED |
| 16 | ARG376 (6.29x29) | ASP443 (8.49x49) | 0.000 | 4.939 | -4.939 | MED |
| 17 | THR241 (5.69x69) | GLU377 (6.30x30) | 4.812 | 0.000 | +4.812 | MED |
| 18 | THR438 (7.54x54) | PHE444 (8.50x50) | 4.685 | 0.000 | +4.685 | MED |
| 19 | GLU158 (34.52x52) | LYS162 (34.56x56) | 0.000 | 4.679 | -4.679 | MED |
| 20 | TRP39 | GLN413 | 4.657 | 0.000 | +4.657 | MED |
| 21 | ASN160 (34.54x54) | ARG163 (34.57x57) | 0.083 | 4.666 | -4.584 | MED |
| 22 | PRO185 (4.59x59) | TYR210 (5.38x39) | 5.922 | 1.355 | +4.567 | MED |
| 23 | TRP39 | TYR405 (6.58x58) | 4.521 | 0.000 | +4.521 | MED |
| 24 | GLN121 (3.22x22) | TYR191 | 11.300 | 6.825 | +4.475 | MED |
| 25 | ASN429 (7.45x45) | ASN433 (7.49x49) | 4.642 | 0.369 | +4.274 | MED |
| 26 | SER152 (3.53x53) | ASN160 (34.54x54) | 0.000 | 4.271 | -4.271 | MED |
| 27 | TRP395 (6.48x48) | ASN429 (7.45x45) | 5.401 | 1.138 | +4.263 | MED |
| 28 | LEU142 (3.43x43) | MET388 (6.41x41) | 0.000 | 4.208 | -4.208 | MED |
| 29 | ALA8 | PHE421 (7.37x36) | 0.000 | 4.167 | -4.167 | MED |
| 30 | THR78 (1.59x59) | ARG83 (12.51x51) | 0.000 | 4.065 | -4.065 | MED |
| 31 | TYR230 (5.58x58) | ALA385 (6.38x38) | 0.000 | 4.027 | -4.027 | MED |
| 32 | LEU77 (1.58x58) | ARG83 (12.51x51) | 1.182 | 5.133 | -3.951 | MED |
| 33 | TYR46 | GLU112 (2.65x64) | 0.000 | 3.944 | -3.944 | MED |
| 34 | ILE139 (3.40x40) | TRP395 (6.48x48) | 3.942 | 0.000 | +3.942 | MED |
| 35 | SER137 (3.38x38) | TRP176 (4.50x50) | 2.847 | 6.765 | -3.919 | MED |
| 36 | TYR234 (5.62x62) | THR381 (6.34x34) | 3.723 | 0.000 | +3.723 | MED |
| 37 | LEU71 (1.52x52) | PHE448 (8.54x54) | 2.555 | 6.199 | -3.644 | MED |
| 38 | TYR230 (5.58x58) | LEU384 (6.37x37) | 6.541 | 2.918 | +3.622 | MED |
| 39 | TYR230 (5.58x58) | MET388 (6.41x41) | 0.589 | 4.201 | -3.612 | MED |
| 40 | LEU190 | LEU204 (45.52x52) | 3.547 | 0.000 | +3.547 | MED |
| 41 | LEU142 (3.43x43) | TYR437 (7.53x53) | 3.488 | 0.000 | +3.488 | MED |
| 42 | LYS162 (34.56x56) | ARG167 (4.41x41) | 4.779 | 1.340 | +3.439 | MED |
| 43 | GLU261 | ASN262 | 6.032 | 2.658 | +3.373 | MED |
| 44 | ALA281 | ARG446 (8.52x52) | 0.000 | 3.364 | -3.364 | MED |
| 45 | ARG242 (5.70x70) | GLU246 (5.74x74) | 0.000 | 3.337 | -3.337 | MED |
| 46 | THR154 (3.55x55) | ARG240 (5.68x68) | 0.000 | 3.160 | -3.160 | MED |
| 47 | SER152 (3.53x53) | GLU377 (6.30x30) | 0.000 | 3.153 | -3.153 | MED |
| 48 | TRP151 (3.52x52) | TYR159 (34.53x53) | 9.343 | 12.493 | -3.150 | MED |
| 49 | LEU190 | GLY203 (45.51x51) | 3.025 | 0.000 | +3.025 | MED |
| 50 | SER189 | ASN205 | 0.000 | 3.018 | -3.018 | MED |
| 51 | TYR191 | PRO194 | 0.000 | 2.958 | -2.958 | MED |
| 52 | PHE380 | LEU384 (6.37x37) | 0.000 | 2.869 | -2.869 | MED |
| 53 | GLN121 (3.22x22) | SER189 | 2.843 | 0.000 | +2.843 | MED |
| 54 | TYR191 | GLN201 | 1.748 | 4.539 | -2.791 | MED |
| 55 | SER146 | MET388 (6.41x41) | 0.000 | 2.772 | -2.772 | MED |
| 56 | ARG149 (3.50x50) | PHE380 | 0.000 | 2.704 | -2.704 | MED |
| 57 | GLY40 | TYR199 | 0.000 | 2.675 | -2.675 | MED |
| 58 | SER365 | ARG369 | 0.000 | 2.654 | -2.654 | MED |
| 59 | ASP148 (3.49x49) | ARG163 (34.57x57) | 6.344 | 3.746 | +2.598 | MED |
| 60 | LEU333 | THR334 | 3.553 | 1.004 | +2.549 | MED |
| 61 | ARG149 (3.50x50) | GLU377 (6.30x30) | 0.000 | 2.536 | -2.536 | MED |
| 62 | GLN193 | PRO200 | 0.377 | 2.900 | -2.522 | MED |
| 63 | ALA115 | GLN201 | 0.284 | 2.792 | -2.508 | MED |
| 64 | LYS238 | GLU377 (6.30x30) | 2.495 | 0.000 | +2.495 | MED |
| 65 | ARG149 (3.50x50) | TYR437 (7.53x53) | 2.492 | 0.000 | +2.492 | MED |
| 66 | GLY68 | PRO434 | 1.656 | 4.097 | -2.441 | MED |
| 67 | THR241 (5.69x69) | LYS378 | 0.000 | 2.436 | -2.436 | MED |
| 68 | TYR116 | TYR199 | 3.460 | 1.026 | +2.434 | MED |
| 69 | ASN111 | TYR116 | 1.781 | 4.185 | -2.404 | MED |
| 70 | ASP97 | SER138 | 2.854 | 0.461 | +2.393 | MED |
| 71 | THR438 (7.54x54) | ARG445 | 0.417 | 2.792 | -2.375 | MED |
| 72 | TRP117 | TRP123 (3.24x24) | 1.785 | 4.141 | -2.356 | MED |
| 73 | ARG149 (3.50x50) | ARG163 (34.57x57) | 0.000 | 2.347 | -2.347 | MED |
| 74 | ILE139 (3.40x40) | PHE391 (6.44x44) | 1.283 | 3.618 | -2.335 | MED |
| 75 | SER152 (3.53x53) | ARG163 (34.57x57) | 0.190 | 2.523 | -2.333 | MED |
| 76 | MET226 | PHE391 (6.44x44) | 2.322 | 0.000 | +2.322 | MED |
| 77 | PHE220 | PHE399 | 0.242 | 2.530 | -2.288 | MED |
| 78 | TYR437 (7.53x53) | PHE444 (8.50x50) | 0.000 | 2.280 | -2.280 | MED |
| 79 | TYR116 | GLN201 | 0.000 | 2.251 | -2.251 | MED |
| 80 | ILE211 | TYR402 | 4.834 | 7.082 | -2.248 | MED |
| 81 | VAL439 | ARG445 | 2.423 | 0.187 | +2.236 | LOW |
| 82 | LEU99 | PHE134 | 5.478 | 7.705 | -2.226 | LOW |
| 83 | GLU329 | SER330 | 1.575 | 3.798 | -2.223 | LOW |
| 84 | PRO42 | TYR116 | 0.000 | 2.197 | -2.197 | LOW |
| 85 | GLU207 | TRP209 | 5.365 | 3.209 | +2.157 | LOW |
| 86 | PHE119 | TRP123 (3.24x24) | 0.461 | 2.567 | -2.106 | LOW |
| 87 | ALA5 | PHE421 (7.37x36) | 0.000 | 2.076 | -2.076 | LOW |
| 88 | ARG80 | GLU287 | 0.000 | 2.044 | -2.044 | LOW |
| 89 | VAL58 | TRP424 | 5.365 | 3.353 | +2.011 | LOW |
| 90 | PHE184 | VAL188 | 0.000 | 2.005 | -2.005 | LOW |
| 91 | ALA75 | SER447 | 2.601 | 0.602 | +2.000 | LOW |
| 92 | ASP206 | TYR405 (6.58x58) | 4.991 | 3.010 | +1.981 | LOW |
| 93 | TYR405 (6.58x58) | GLN413 | 1.949 | 0.000 | +1.949 | LOW |
| 94 | THR208 | ARG409 | 1.117 | 3.060 | -1.943 | LOW |
| 95 | TYR230 (5.58x58) | VAL387 | 1.940 | 0.000 | +1.940 | LOW |
| 96 | CYS394 | ASN429 (7.45x45) | 3.325 | 1.394 | +1.931 | LOW |
| 97 | ALA5 | PRO417 | 0.000 | 1.882 | -1.882 | LOW |
| 98 | MET114 | TYR116 | 3.359 | 1.484 | +1.876 | LOW |
| 99 | PRO253 | ASP254 | 0.000 | 1.860 | -1.860 | LOW |
| 100 | GLY227 | MET388 (6.41x41) | 1.855 | 0.000 | +1.855 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.24 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 71-78 | - | 0 | 78 (-4.1), 77 (-4.0), 71 (-3.6) | 3 |
| TM2 | 107-112 | - | 0 | 107 (-7.6), 112 (-3.9) | 2 |
| TM3 | 121-154 | 121 (4.5), 139 (3.9) | 2 | 123 (-7.6), 148 (-6.8), 149 (-6.8), 152 (-5.5), 142 (-4.2), 137 (-3.9), 154 (-3.2), 151 (-3.1) | 8 |
| TM4 | 167-185 | 185 (4.6), 167 (3.4) | 2 | 176 (-3.9) | 1 |
| TM5 | 210-246 | 241 (4.8), 210 (4.6), 234 (3.7) | 3 | 230 (-4.0), 242 (-3.3), 246 (-3.3), 240 (-3.2) | 4 |
| TM6 | 376-405 | 383 (5.0), 377 (4.8), 405 (4.5), 381 (3.7), 384 (3.6) | 5 | 395 (-8.2), 391 (-6.1), 376 (-4.9), 388 (-4.2), 385 (-4.0) | 5 |
| TM7 | 421-440 | 440 (5.0), 438 (4.7), 433 (4.3), 437 (3.5) | 4 | 426 (-8.2), 429 (-5.7), 421 (-4.2) | 3 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 83-83 | - | 0 | 83 (-4.1) | 1 |
| ICL2 | 158-163 | - | 0 | 158 (-4.7), 162 (-4.7), 160 (-4.6), 163 (-4.6), 159 (-3.1) | 5 |
| ICL3 | 261-284 | 261 (3.4), 262 (3.4) | 2 | 284 (-7.6), 281 (-3.4) | 2 |
| ECL1 | - | - | 0 | - | 0 |
| ECL2 | 189-206 | 190 (7.2), 205 (7.2), 191 (7.0), 200 (7.0), 192 (6.2), 201 (6.2), 206 (5.1), 204 (3.5) | 8 | 199 (-8.9), 203 (-5.9), 189 (-3.0) | 3 |
| ECL3 | 413-413 | 413 (4.7) | 1 | - | 0 |
| H8 | 443-450 | 450 (10.2), 444 (4.7) | 2 | 443 (-4.9), 448 (-3.6), 446 (-3.4) | 3 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
92 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 450 | p.His450Tyr | c.1348C>T | 1.37e-06 | 2 / 0 | 10.19 | 0.216 | BENIGN | 0.60 | rs923942289 |
| 454 | p.Arg454Gln | c.1361G>A | 6.86e-07 | 1 / 0 | 10.19 | 0.127 | BENIGN | 0.56 | |
| 450 | p.His450Asn | c.1348C>A | 6.86e-07 | 1 / 0 | 10.19 | - | nan | - | rs923942289 |
| 42 | p.Pro42Thr | c.124C>A | 7.56e-07 | 1 / 0 | 8.90 | 0.091 | BENIGN | 0.49 | |
| 199 | p.Tyr199Phe | c.596A>T | 1.10e-05 | 16 / 0 | 8.90 | 0.089 | BENIGN | 0.33 | rs944925319 |
| 42 | p.Pro42Ser | c.124C>T | 7.56e-07 | 1 / 0 | 8.90 | - | nan | - | |
| 426 | p.Gly426Arg | c.1276G>C | 1.37e-06 | 2 / 0 | 8.20 | 0.999 | PATHOGENIC | 0.99 | |
| 426 | p.Gly426Ser | c.1276G>A | 1.37e-06 | 2 / 0 | 8.20 | - | nan | - | |
| 284 | p.Glu284Asp | c.852G>T | 1.50e-06 | 2 / 0 | 7.60 | 0.073 | BENIGN | 0.46 | rs1471047437 |
| 205 | p.Asn205Ser | c.614A>G | 5.49e-06 | 8 / 0 | 7.21 | 0.299 | BENIGN | 0.63 | rs1223005173 |
| 190 | p.Leu190Phe | c.568C>T | 2.74e-06 | 4 / 0 | 7.21 | 0.088 | BENIGN | 0.46 | |
| 190 | p.Leu190Val | c.568C>G | 2.06e-06 | 3 / 0 | 7.21 | - | nan | - | rs1735465196 |
| 190 | p.Leu190Pro | c.569T>C | 6.86e-07 | 1 / 0 | 7.21 | - | nan | - | |
| 205 | p.Asn205Lys | c.615C>A | 4.80e-06 | 7 / 0 | 7.21 | - | nan | - | |
| 200 | p.Pro200Leu | c.599C>T | 6.17e-06 | 9 / 0 | 7.04 | 0.435 | AMBIGUOUS | 0.58 | rs775140301 |
| 191 | p.Tyr191His | c.571T>C | 6.86e-07 | 1 / 0 | 7.04 | 0.120 | BENIGN | 0.34 | |
| 191 | p.Tyr191Phe | c.572A>T | 1.37e-06 | 2 / 0 | 7.04 | - | nan | - | rs780306885 |
| 191 | p.Tyr191Ser | c.572A>C | 6.86e-07 | 1 / 0 | 7.04 | - | nan | - | rs780306885 |
| 200 | p.Pro200Arg | c.599C>G | 6.86e-07 | 1 / 0 | 7.04 | - | nan | - | rs775140301 |
| 149 | p.Arg149Gly | c.445C>G | 6.85e-07 | 1 / 0 | 6.84 | 0.998 | PATHOGENIC | 0.99 | |
| 148 | p.Asp148Tyr | c.442G>T | 6.85e-07 | 1 / 0 | 6.84 | 0.997 | PATHOGENIC | 1.00 | |
| 149 | p.Arg149His | c.446G>A | 3.43e-06 | 5 / 0 | 6.84 | - | nan | - | rs1189337699 |
| 201 | p.Gln201His | c.603G>T | 6.57e-06 | 1 / 0 | 6.23 | 0.305 | BENIGN | 0.47 | rs1735466394 |
| 192 | p.Arg192Gly | c.574C>G | 3.43e-06 | 5 / 0 | 6.23 | 0.137 | BENIGN | 0.49 | rs749478380 |
| 192 | p.Arg192His | c.575G>A | 6.86e-07 | 1 / 0 | 6.23 | - | nan | - | rs769028798 |
| 192 | p.Arg192Leu | c.575G>T | 6.86e-07 | 1 / 0 | 6.23 | - | nan | - | rs769028798 |
| 203 | p.Gly203Ser | c.607G>A | 1.37e-06 | 2 / 0 | 5.92 | 0.084 | BENIGN | 0.39 | rs2108687764 |
| 203 | p.Gly203Asp | c.608G>A | 6.86e-07 | 1 / 0 | 5.92 | - | nan | - | rs2108687768 |
| 203 | p.Gly203Ala | c.608G>C | 4.12e-06 | 6 / 0 | 5.92 | - | nan | - | |
| 429 | p.Asn429Lys | c.1287C>G | 6.85e-07 | 1 / 0 | 5.73 | 1.000 | PATHOGENIC | 0.99 | rs1237148004 |
| 152 | p.Ser152Trp | c.455C>G | 6.86e-07 | 1 / 0 | 5.45 | 0.992 | PATHOGENIC | 0.70 | |
| 152 | p.Ser152Leu | c.455C>T | 6.86e-07 | 1 / 0 | 5.45 | - | nan | - | |
| 206 | p.Asp206Asn | c.616G>A | 6.86e-07 | 1 / 0 | 5.11 | 0.253 | BENIGN | 0.53 | |
| 383 | p.Val383Leu | c.1147G>T | 6.85e-07 | 1 / 0 | 4.97 | 0.982 | PATHOGENIC | 0.66 | |
| 376 | p.Arg376Leu | c.1127G>T | 1.37e-06 | 2 / 0 | 4.94 | 0.982 | PATHOGENIC | 0.82 | |
| 376 | p.Arg376Pro | c.1127G>C | 2.74e-06 | 4 / 0 | 4.94 | - | nan | - | rs1735487403 |
| 376 | p.Arg376His | c.1127G>A | 6.85e-07 | 1 / 0 | 4.94 | - | nan | - | |
| 377 | p.Glu377Gln | c.1129G>C | 6.85e-07 | 1 / 0 | 4.81 | 0.975 | PATHOGENIC | 0.98 | |
| 241 | p.Thr241Ala | c.721A>G | 9.14e-06 | 13 / 0 | 4.81 | 0.316 | BENIGN | 0.54 | rs1735470264 |
| 241 | p.Thr241Met | c.722C>T | 7.04e-07 | 1 / 0 | 4.81 | - | nan | - | |
| 438 | p.Thr438Arg | c.1313C>G | 6.57e-06 | 1 / 0 | 4.69 | 0.991 | PATHOGENIC | 0.81 | rs762125237 |
| 438 | p.Thr438Lys | c.1313C>A | 6.85e-07 | 1 / 0 | 4.69 | - | nan | - | rs762125237 |
| 438 | p.Thr438Met | c.1313C>T | 1.37e-06 | 2 / 0 | 4.69 | - | nan | - | rs762125237 |
| 158 | p.Glu158Lys | c.472G>A | 9.46e-05 | 134 / 2 | 4.68 | 0.553 | AMBIGUOUS | 0.49 | rs202121184 |
| 158 | p.Glu158Asp | c.474G>C | 2.63e-05 | 4 / 0 | 4.68 | - | nan | - | rs527926159 |
| 413 | p.Gln413Arg | c.1238A>G | 2.74e-06 | 4 / 0 | 4.66 | 0.064 | BENIGN | 0.35 | rs947271279 |
| 413 | p.Gln413His | c.1239G>T | 6.85e-07 | 1 / 0 | 4.66 | - | nan | - | |
| 163 | p.Arg163Cys | c.487C>T | 6.57e-06 | 1 / 0 | 4.58 | 0.980 | PATHOGENIC | 0.92 | rs2108706615 |
| 160 | p.Asn160Thr | c.479A>C | 2.06e-06 | 3 / 0 | 4.58 | 0.714 | PATHOGENIC | 0.57 | rs1291101803 |
| 160 | p.Asn160Lys | c.480C>A | 6.86e-07 | 1 / 0 | 4.58 | - | nan | - | |
| 160 | p.Asn160Lys | c.480C>G | 6.86e-07 | 1 / 0 | 4.58 | - | nan | - | |
| 163 | p.Arg163His | c.488G>A | 6.86e-07 | 1 / 0 | 4.58 | - | nan | - | rs1735461559 |
| 405 | p.Tyr405Cys | c.1214A>G | 6.85e-07 | 1 / 0 | 4.52 | 0.584 | PATHOGENIC | 0.33 | rs1219213054 |
| 121 | p.Gln121Arg | c.362A>G | 2.63e-05 | 4 / 0 | 4.47 | 0.074 | BENIGN | 0.40 | rs371654820 |
| 433 | p.Asn433Ile | c.1298A>T | 6.85e-07 | 1 / 0 | 4.27 | 0.998 | PATHOGENIC | 1.00 | rs1157512558 |
| 388 | p.Met388Leu | c.1162A>C | 6.57e-06 | 1 / 0 | 4.21 | 0.689 | PATHOGENIC | 0.76 | rs1735488508 |
| 421 | p.Phe421Val | c.1261T>G | 6.85e-07 | 1 / 0 | 4.17 | 0.439 | AMBIGUOUS | 0.63 | rs781065132 |
| 8 | p.Ala8Thr | c.22G>A | 6.67e-06 | 1 / 0 | 4.17 | 0.251 | BENIGN | 0.79 | rs1434779145 |
| 8 | p.Ala8Val | c.23C>T | 9.48e-07 | 1 / 0 | 4.17 | - | nan | - | rs1169138902 |
| 421 | p.Phe421Cys | c.1262T>G | 6.85e-07 | 1 / 0 | 4.17 | - | nan | - | rs1378090790 |
| 421 | p.Phe421Leu | c.1263C>G | 1.16e-05 | 17 / 0 | 4.17 | - | nan | - | |
| 78 | p.Thr78Pro | c.232A>C | 6.97e-07 | 1 / 0 | 4.07 | 0.940 | PATHOGENIC | 0.70 | |
| 230 | p.Tyr230Cys | c.689A>G | 6.92e-07 | 1 / 0 | 4.03 | 0.980 | PATHOGENIC | 0.95 | |
| 385 | p.Ala385Ser | c.1153G>T | 1.37e-06 | 2 / 0 | 4.03 | 0.282 | BENIGN | 0.70 | |
| 385 | p.Ala385Thr | c.1153G>A | 6.57e-06 | 1 / 0 | 4.03 | - | nan | - | rs1398624082 |
| 385 | p.Ala385Val | c.1154C>T | 6.85e-07 | 1 / 0 | 4.03 | - | nan | - | |
| 112 | p.Glu112Asp | c.336G>C | 6.86e-07 | 1 / 0 | 3.94 | 0.972 | PATHOGENIC | 0.80 | |
| 176 | p.Trp176Arg | c.526T>C | 6.87e-07 | 1 / 0 | 3.92 | 1.000 | PATHOGENIC | 0.99 | rs1472843513 |
| 137 | p.Ser137Trp | c.410C>G | 6.85e-07 | 1 / 0 | 3.92 | 0.999 | PATHOGENIC | 0.71 | |
| 234 | p.Tyr234His | c.700T>C | 6.94e-07 | 1 / 0 | 3.72 | 0.947 | PATHOGENIC | 0.87 | rs772484282 |
| 381 | p.Thr381Ser | c.1141A>T | 6.85e-07 | 1 / 0 | 3.72 | 0.909 | PATHOGENIC | 0.70 | |
| 381 | p.Thr381Ala | c.1141A>G | 3.42e-06 | 5 / 0 | 3.72 | - | nan | - | rs1735487897 |
| 381 | p.Thr381Ser | c.1142C>G | 6.85e-07 | 1 / 0 | 3.72 | - | nan | - | |
| 448 | p.Phe448Cys | c.1343T>G | 6.85e-07 | 1 / 0 | 3.64 | 0.994 | PATHOGENIC | 0.97 | |
| 384 | p.Leu384Val | c.1150C>G | 4.79e-06 | 7 / 0 | 3.62 | 0.963 | PATHOGENIC | 0.98 | |
| 204 | p.Leu204Val | c.610C>G | 6.86e-07 | 1 / 0 | 3.55 | 0.590 | PATHOGENIC | 0.78 | |
| 437 | p.Tyr437Cys | c.1310A>G | 2.05e-06 | 3 / 0 | 3.49 | 0.997 | PATHOGENIC | 0.99 | rs1358242924 |
| 167 | p.Arg167His | c.500G>A | 6.86e-07 | 1 / 0 | 3.44 | 0.578 | PATHOGENIC | 0.95 | |
| 262 | p.Asn262Lys | c.786C>G | 2.17e-06 | 3 / 0 | 3.37 | 0.727 | PATHOGENIC | 0.46 | rs1429513969 |
| 261 | p.Glu261Lys | c.781G>A | 1.44e-06 | 2 / 0 | 3.37 | 0.325 | BENIGN | 0.42 | rs1398239842 |
| 446 | p.Arg446Leu | c.1337G>T | 4.11e-06 | 6 / 0 | 3.36 | 0.524 | AMBIGUOUS | 0.61 | rs1133452 |
| 281 | p.Ala281Thr | c.841G>A | 1.49e-06 | 2 / 0 | 3.36 | 0.075 | BENIGN | 0.39 | rs1369280633 |
| 281 | p.Ala281Asp | c.842C>A | 7.43e-07 | 1 / 0 | 3.36 | - | nan | - | |
| 281 | p.Ala281Val | c.842C>T | 6.62e-06 | 1 / 0 | 3.36 | - | nan | - | rs1306630441 |
| 242 | p.Arg242Cys | c.724C>T | 7.05e-07 | 1 / 0 | 3.34 | 0.597 | PATHOGENIC | 0.60 | |
| 242 | p.Arg242Pro | c.725G>C | 7.06e-07 | 1 / 0 | 3.34 | - | nan | - | |
| 240 | p.Arg240Cys | c.718C>T | 1.41e-06 | 2 / 0 | 3.16 | 0.948 | PATHOGENIC | 0.73 | |
| 154 | p.Thr154Met | c.461C>T | 1.37e-06 | 2 / 0 | 3.16 | 0.814 | PATHOGENIC | 0.70 | |
| 240 | p.Arg240Leu | c.719G>T | 7.03e-07 | 1 / 0 | 3.16 | - | nan | - | |
| 240 | p.Arg240His | c.719G>A | 1.34e-05 | 19 / 0 | 3.16 | - | nan | - | rs778196873 |
| 151 | p.Trp151Cys | c.453G>C | 6.85e-07 | 1 / 0 | 3.15 | 0.919 | PATHOGENIC | 0.67 | |
| 189 | p.Ser189Leu | c.566C>T | 6.86e-07 | 1 / 0 | 3.02 | 0.372 | AMBIGUOUS | 0.47 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.24, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 450 | HIS | 454 | ARG | 15.830 | 5.638 | 10.193 | 10.193 |
| 42 | PRO | 199 | TYR | 0.000 | 8.902 | -8.902 | 8.902 |
| 395 | TRP | 426 | GLY | 3.029 | 11.224 | -8.196 | 8.196 |
| 107 | PHE | 123 | TRP | 0.000 | 7.613 | -7.613 | 7.613 |
| 284 | GLU | 454 | ARG | 0.000 | 7.601 | -7.601 | 7.601 |
| 190 | LEU | 205 | ASN | 7.209 | 0.000 | 7.209 | 7.209 |
| 191 | TYR | 200 | PRO | 7.044 | 0.000 | 7.044 | 7.044 |
| 148 | ASP | 149 | ARG | 0.000 | 6.843 | -6.843 | 6.843 |
| 192 | ARG | 201 | GLN | 6.231 | 0.000 | 6.231 | 6.231 |
| 391 | PHE | 395 | TRP | 1.906 | 7.986 | -6.080 | 6.080 |
| 191 | TYR | 203 | GLY | 0.000 | 5.925 | -5.925 | 5.925 |
| 391 | PHE | 429 | ASN | 0.413 | 6.141 | -5.728 | 5.728 |
| 149 | ARG | 152 | SER | 0.000 | 5.451 | -5.451 | 5.451 |
| 192 | ARG | 206 | ASP | 5.114 | 0.000 | 5.114 | 5.114 |
| 383 | VAL | 440 | PHE | 7.482 | 2.516 | 4.966 | 4.966 |
| 376 | ARG | 443 | ASP | 0.000 | 4.939 | -4.939 | 4.939 |
| 241 | THR | 377 | GLU | 4.812 | 0.000 | 4.812 | 4.812 |
| 438 | THR | 444 | PHE | 4.685 | 0.000 | 4.685 | 4.685 |
| 158 | GLU | 162 | LYS | 0.000 | 4.679 | -4.679 | 4.679 |
| 39 | TRP | 413 | GLN | 4.657 | 0.000 | 4.657 | 4.657 |
| 160 | ASN | 163 | ARG | 0.083 | 4.666 | -4.584 | 4.584 |
| 185 | PRO | 210 | TYR | 5.922 | 1.355 | 4.567 | 4.567 |
| 39 | TRP | 405 | TYR | 4.521 | 0.000 | 4.521 | 4.521 |
| 121 | GLN | 191 | TYR | 11.300 | 6.825 | 4.475 | 4.475 |
| 429 | ASN | 433 | ASN | 4.642 | 0.369 | 4.274 | 4.274 |
| 152 | SER | 160 | ASN | 0.000 | 4.271 | -4.271 | 4.271 |
| 395 | TRP | 429 | ASN | 5.401 | 1.138 | 4.263 | 4.263 |
| 142 | LEU | 388 | MET | 0.000 | 4.208 | -4.208 | 4.208 |
| 8 | ALA | 421 | PHE | 0.000 | 4.167 | -4.167 | 4.167 |
| 78 | THR | 83 | ARG | 0.000 | 4.065 | -4.065 | 4.065 |
| 230 | TYR | 385 | ALA | 0.000 | 4.027 | -4.027 | 4.027 |
| 77 | LEU | 83 | ARG | 1.182 | 5.133 | -3.951 | 3.951 |
| 46 | TYR | 112 | GLU | 0.000 | 3.944 | -3.944 | 3.944 |
| 139 | ILE | 395 | TRP | 3.942 | 0.000 | 3.942 | 3.942 |
| 137 | SER | 176 | TRP | 2.847 | 6.765 | -3.919 | 3.919 |
| 234 | TYR | 381 | THR | 3.723 | 0.000 | 3.723 | 3.723 |
| 71 | LEU | 448 | PHE | 2.555 | 6.199 | -3.644 | 3.644 |
| 230 | TYR | 384 | LEU | 6.541 | 2.918 | 3.622 | 3.622 |
| 230 | TYR | 388 | MET | 0.589 | 4.201 | -3.612 | 3.612 |
| 190 | LEU | 204 | LEU | 3.547 | 0.000 | 3.547 | 3.547 |
| 142 | LEU | 437 | TYR | 3.488 | 0.000 | 3.488 | 3.488 |
| 162 | LYS | 167 | ARG | 4.779 | 1.340 | 3.439 | 3.439 |
| 261 | GLU | 262 | ASN | 6.032 | 2.658 | 3.373 | 3.373 |
| 281 | ALA | 446 | ARG | 0.000 | 3.364 | -3.364 | 3.364 |
| 242 | ARG | 246 | GLU | 0.000 | 3.337 | -3.337 | 3.337 |
| 154 | THR | 240 | ARG | 0.000 | 3.160 | -3.160 | 3.160 |
| 152 | SER | 377 | GLU | 0.000 | 3.153 | -3.153 | 3.153 |
| 151 | TRP | 159 | TYR | 9.343 | 12.493 | -3.150 | 3.150 |
| 190 | LEU | 203 | GLY | 3.025 | 0.000 | 3.025 | 3.025 |
| 189 | SER | 205 | ASN | 0.000 | 3.018 | -3.018 | 3.018 |
| 191 | TYR | 194 | PRO | 0.000 | 2.958 | -2.958 | 2.958 |
| 380 | PHE | 384 | LEU | 0.000 | 2.869 | -2.869 | 2.869 |
| 121 | GLN | 189 | SER | 2.843 | 0.000 | 2.843 | 2.843 |
| 191 | TYR | 201 | GLN | 1.748 | 4.539 | -2.791 | 2.791 |
| 146 | SER | 388 | MET | 0.000 | 2.772 | -2.772 | 2.772 |
| 149 | ARG | 380 | PHE | 0.000 | 2.704 | -2.704 | 2.704 |
| 40 | GLY | 199 | TYR | 0.000 | 2.675 | -2.675 | 2.675 |
| 365 | SER | 369 | ARG | 0.000 | 2.654 | -2.654 | 2.654 |
| 148 | ASP | 163 | ARG | 6.344 | 3.746 | 2.598 | 2.598 |
| 333 | LEU | 334 | THR | 3.553 | 1.004 | 2.549 | 2.549 |
| 149 | ARG | 377 | GLU | 0.000 | 2.536 | -2.536 | 2.536 |
| 193 | GLN | 200 | PRO | 0.377 | 2.900 | -2.522 | 2.522 |
| 115 | ALA | 201 | GLN | 0.284 | 2.792 | -2.508 | 2.508 |
| 238 | LYS | 377 | GLU | 2.495 | 0.000 | 2.495 | 2.495 |
| 149 | ARG | 437 | TYR | 2.492 | 0.000 | 2.492 | 2.492 |
| 68 | GLY | 434 | PRO | 1.656 | 4.097 | -2.441 | 2.441 |
| 241 | THR | 378 | LYS | 0.000 | 2.436 | -2.436 | 2.436 |
| 116 | TYR | 199 | TYR | 3.460 | 1.026 | 2.434 | 2.434 |
| 111 | ASN | 116 | TYR | 1.781 | 4.185 | -2.404 | 2.404 |
| 97 | ASP | 138 | SER | 2.854 | 0.461 | 2.393 | 2.393 |
| 438 | THR | 445 | ARG | 0.417 | 2.792 | -2.375 | 2.375 |
| 117 | TRP | 123 | TRP | 1.785 | 4.141 | -2.356 | 2.356 |
| 149 | ARG | 163 | ARG | 0.000 | 2.347 | -2.347 | 2.347 |
| 139 | ILE | 391 | PHE | 1.283 | 3.618 | -2.335 | 2.335 |
| 152 | SER | 163 | ARG | 0.190 | 2.523 | -2.333 | 2.333 |
| 226 | MET | 391 | PHE | 2.322 | 0.000 | 2.322 | 2.322 |
| 220 | PHE | 399 | PHE | 0.242 | 2.530 | -2.288 | 2.288 |
| 437 | TYR | 444 | PHE | 0.000 | 2.280 | -2.280 | 2.280 |
| 116 | TYR | 201 | GLN | 0.000 | 2.251 | -2.251 | 2.251 |
| 211 | ILE | 402 | TYR | 4.834 | 7.082 | -2.248 | 2.248 |
| 439 | VAL | 445 | ARG | 2.423 | 0.187 | 2.236 | 2.236 |
| 99 | LEU | 134 | PHE | 5.478 | 7.705 | -2.226 | 2.226 |
| 329 | GLU | 330 | SER | 1.575 | 3.798 | -2.223 | 2.223 |
| 42 | PRO | 116 | TYR | 0.000 | 2.197 | -2.197 | 2.197 |
| 207 | GLU | 209 | TRP | 5.365 | 3.209 | 2.157 | 2.157 |
| 119 | PHE | 123 | TRP | 0.461 | 2.567 | -2.106 | 2.106 |
| 5 | ALA | 421 | PHE | 0.000 | 2.076 | -2.076 | 2.076 |
| 80 | ARG | 287 | GLU | 0.000 | 2.044 | -2.044 | 2.044 |
| 58 | VAL | 424 | TRP | 5.365 | 3.353 | 2.011 | 2.011 |
| 184 | PHE | 188 | VAL | 0.000 | 2.005 | -2.005 | 2.005 |
| 75 | ALA | 447 | SER | 2.601 | 0.602 | 2.000 | 2.000 |
| 206 | ASP | 405 | TYR | 4.991 | 3.010 | 1.981 | 1.981 |
| 405 | TYR | 413 | GLN | 1.949 | 0.000 | 1.949 | 1.949 |
| 208 | THR | 409 | ARG | 1.117 | 3.060 | -1.943 | 1.943 |
| 230 | TYR | 387 | VAL | 1.940 | 0.000 | 1.940 | 1.940 |
| 394 | CYS | 429 | ASN | 3.325 | 1.394 | 1.931 | 1.931 |
| 5 | ALA | 417 | PRO | 0.000 | 1.882 | -1.882 | 1.882 |
| 114 | MET | 116 | TYR | 3.359 | 1.484 | 1.876 | 1.876 |
| 253 | PRO | 254 | ASP | 0.000 | 1.860 | -1.860 | 1.860 |
| 227 | GLY | 388 | MET | 1.855 | 0.000 | 1.855 | 1.855 |
| 86 | GLN | 148 | ASP | 0.426 | 2.273 | -1.847 | 1.847 |
| 230 | TYR | 381 | THR | 0.000 | 1.838 | -1.838 | 1.838 |
| 182 | ILE | 210 | TYR | 1.823 | 0.000 | 1.823 | 1.823 |
| 245 | SER | 370 | ARG | 1.809 | 0.000 | 1.809 | 1.809 |
| 93 | LEU | 142 | LEU | 2.240 | 0.439 | 1.801 | 1.801 |
| 257 | SER | 258 | PRO | 2.210 | 0.413 | 1.797 | 1.797 |
| 86 | GLN | 163 | ARG | 8.744 | 6.951 | 1.793 | 1.793 |
| 204 | LEU | 402 | TYR | 2.665 | 4.452 | -1.787 | 1.787 |
| 223 | CYS | 391 | PHE | 1.770 | 0.000 | 1.770 | 1.770 |
| 238 | LYS | 242 | ARG | 1.760 | 0.000 | 1.760 | 1.760 |
| 153 | VAL | 240 | ARG | 2.326 | 4.050 | -1.724 | 1.724 |
| 100 | VAL | 134 | PHE | 3.725 | 2.034 | 1.691 | 1.691 |
| 111 | ASN | 202 | CYS | 1.690 | 0.000 | 1.690 | 1.690 |
| 137 | SER | 141 | HIS | 0.563 | 2.244 | -1.682 | 1.682 |
| 186 | PRO | 205 | ASN | 1.674 | 0.000 | 1.674 | 1.674 |
| 136 | THR | 218 | SER | 2.117 | 0.455 | 1.662 | 1.662 |
| 387 | VAL | 433 | ASN | 0.000 | 1.640 | -1.640 | 1.640 |
| 43 | ARG | 198 | ALA | 1.631 | 0.000 | 1.631 | 1.631 |
| 442 | GLN | 445 | ARG | 1.622 | 0.000 | 1.622 | 1.622 |
| 129 | ALA | 183 | SER | 1.686 | 3.308 | -1.622 | 1.622 |
| 421 | PHE | 425 | ILE | 3.974 | 5.597 | -1.622 | 1.622 |
| 334 | THR | 335 | ALA | 0.000 | 1.619 | -1.619 | 1.619 |
| 190 | LEU | 206 | ASP | 1.618 | 0.000 | 1.618 | 1.618 |
| 93 | LEU | 141 | HIS | 2.852 | 1.239 | 1.614 | 1.614 |
| 383 | VAL | 436 | ILE | 0.000 | 1.607 | -1.607 | 1.607 |
| 82 | LEU | 444 | PHE | 4.918 | 3.315 | 1.603 | 1.603 |
| 379 | ARG | 442 | GLN | 0.000 | 1.567 | -1.567 | 1.567 |
| 76 | VAL | 83 | ARG | 0.312 | 1.872 | -1.560 | 1.560 |
| 194 | PRO | 197 | ALA | 1.745 | 0.192 | 1.554 | 1.554 |
| 108 | SER | 424 | TRP | 0.432 | 1.982 | -1.550 | 1.550 |
| 395 | TRP | 398 | PHE | 0.000 | 1.542 | -1.542 | 1.542 |
| 233 | ILE | 380 | PHE | 1.529 | 0.000 | 1.529 | 1.529 |
| 41 | PRO | 199 | TYR | 0.000 | 1.518 | -1.518 | 1.518 |
| 395 | TRP | 427 | TYR | 0.000 | 1.508 | -1.508 | 1.508 |
| 205 | ASN | 402 | TYR | 3.995 | 2.496 | 1.498 | 1.498 |
| 107 | PHE | 127 | TYR | 2.724 | 1.230 | 1.494 | 1.494 |
| 186 | PRO | 207 | GLU | 1.483 | 0.000 | 1.483 | 1.483 |
| 145 | ILE | 384 | LEU | 0.000 | 1.476 | -1.476 | 1.476 |
| 69 | ASN | 94 | ALA | 6.167 | 4.703 | 1.464 | 1.464 |
| 100 | VAL | 105 | MET | 3.708 | 5.165 | -1.457 | 1.457 |
| 185 | PRO | 186 | PRO | 0.317 | 1.770 | -1.453 | 1.453 |
| 149 | ARG | 384 | LEU | 0.000 | 1.434 | -1.434 | 1.434 |
| 132 | VAL | 183 | SER | 3.917 | 2.491 | 1.426 | 1.426 |
| 410 | GLU | 413 | GLN | 1.422 | 0.000 | 1.422 | 1.422 |
| 72 | VAL | 437 | TYR | 0.000 | 1.421 | -1.421 | 1.421 |
| 123 | TRP | 126 | VAL | 0.586 | 2.007 | -1.421 | 1.421 |
| 190 | LEU | 201 | GLN | 1.417 | 0.000 | 1.417 | 1.417 |
| 114 | MET | 118 | TYR | 0.000 | 1.413 | -1.413 | 1.413 |
| 142 | LEU | 433 | ASN | 1.407 | 0.000 | 1.407 | 1.407 |
| 192 | ARG | 200 | PRO | 1.393 | 0.000 | 1.393 | 1.393 |
| 141 | HIS | 176 | TRP | 4.116 | 2.744 | 1.372 | 1.372 |
| 143 | CYS | 225 | ILE | 1.372 | 0.000 | 1.372 | 1.372 |
| 398 | PHE | 399 | PHE | 0.648 | 2.001 | -1.353 | 1.353 |
| 248 | ARG | 274 | GLY | 0.000 | 1.353 | -1.353 | 1.353 |
| 41 | PRO | 46 | TYR | 1.342 | 0.000 | 1.342 | 1.342 |
| 212 | LEU | 403 | SER | 0.318 | 1.660 | -1.342 | 1.342 |
| 404 | LEU | 412 | CYS | 0.321 | 1.657 | -1.336 | 1.336 |
| 42 | PRO | 45 | GLN | 1.335 | 0.000 | 1.335 | 1.335 |
| 125 | GLY | 187 | LEU | 0.329 | 1.652 | -1.323 | 1.323 |
| 281 | ALA | 282 | ASP | 0.434 | 1.743 | -1.309 | 1.309 |
| 223 | CYS | 388 | MET | 1.286 | 0.000 | 1.286 | 1.286 |
| 234 | TYR | 384 | LEU | 1.285 | 0.000 | 1.285 | 1.285 |
| 401 | SER | 419 | PHE | 0.330 | 1.576 | -1.246 | 1.246 |
| 286 | ASP | 288 | SER | 1.797 | 3.040 | -1.244 | 1.244 |
| 146 | SER | 230 | TYR | 1.622 | 2.847 | -1.225 | 1.225 |
| 147 | LEU | 225 | ILE | 1.220 | 0.000 | 1.220 | 1.220 |
| 150 | TYR | 154 | THR | 4.448 | 3.245 | 1.203 | 1.203 |
| 140 | VAL | 175 | VAL | 2.696 | 3.898 | -1.202 | 1.202 |
| 86 | GLN | 149 | ARG | 0.000 | 1.198 | -1.198 | 1.198 |
| 136 | THR | 182 | ILE | 0.373 | 1.568 | -1.195 | 1.195 |
| 219 | PHE | 392 | VAL | 0.000 | 1.183 | -1.183 | 1.183 |
| 145 | ILE | 149 | ARG | 1.352 | 0.174 | 1.178 | 1.178 |
| 3 | SER | 4 | PRO | 1.839 | 0.663 | 1.176 | 1.176 |
| 139 | ILE | 399 | PHE | 1.176 | 0.000 | 1.176 | 1.176 |
| 219 | PHE | 399 | PHE | 11.233 | 12.398 | -1.165 | 1.165 |
| 145 | ILE | 388 | MET | 0.000 | 1.158 | -1.158 | 1.158 |
| 76 | VAL | 87 | ASN | 1.164 | 2.319 | -1.156 | 1.156 |
| 150 | TYR | 233 | ILE | 2.139 | 3.278 | -1.139 | 1.139 |
| 117 | TRP | 127 | TYR | 3.460 | 4.593 | -1.133 | 1.133 |
| 117 | TRP | 200 | PRO | 4.346 | 5.475 | -1.128 | 1.128 |
| 72 | VAL | 448 | PHE | 1.726 | 2.854 | -1.128 | 1.128 |
| 134 | PHE | 176 | TRP | 0.745 | 1.873 | -1.128 | 1.128 |
| 108 | SER | 427 | TYR | 2.037 | 3.159 | -1.122 | 1.122 |
| 259 | THR | 260 | THR | 1.113 | 0.000 | 1.113 | 1.113 |
| 164 | THR | 167 | ARG | 0.711 | 1.815 | -1.104 | 1.104 |
| 237 | ALA | 380 | PHE | 1.094 | 0.000 | 1.094 | 1.094 |
| 87 | ASN | 380 | PHE | 0.000 | 1.092 | -1.092 | 1.092 |
| 243 | THR | 246 | GLU | 0.000 | 1.090 | -1.090 | 1.090 |
| 219 | PHE | 220 | PHE | 2.460 | 3.541 | -1.081 | 1.081 |
| 76 | VAL | 82 | LEU | 2.454 | 3.524 | -1.070 | 1.070 |
| 69 | ASN | 430 | SER | 1.128 | 2.196 | -1.067 | 1.067 |
| 388 | MET | 392 | VAL | 1.052 | 0.000 | 1.052 | 1.052 |
| 142 | LEU | 391 | PHE | 1.221 | 2.271 | -1.051 | 1.051 |
| 87 | ASN | 444 | PHE | 1.050 | 0.000 | 1.050 | 1.050 |
| 355 | PHE | 359 | ARG | 1.083 | 0.043 | 1.040 | 1.040 |
| 109 | LEU | 424 | TRP | 1.298 | 2.338 | -1.039 | 1.039 |
| 129 | ALA | 186 | PRO | 0.000 | 1.026 | -1.026 | 1.026 |
| 131 | ASP | 427 | TYR | 5.024 | 6.035 | -1.011 | 1.011 |
| 248 | ARG | 370 | ARG | 1.009 | 0.000 | 1.009 | 1.009 |
| 74 | ILE | 451 | ILE | 0.846 | 1.854 | -1.009 | 1.009 |
| 386 | VAL | 436 | ILE | 0.000 | 1.004 | -1.004 | 1.004 |
| 186 | PRO | 188 | VAL | 1.003 | 0.000 | 1.003 | 1.003 |
| 111 | ASN | 117 | TRP | 3.727 | 4.717 | -0.990 | 0.990 |
| 219 | PHE | 223 | CYS | 1.830 | 2.795 | -0.965 | 0.965 |
| 141 | HIS | 175 | VAL | 4.562 | 5.525 | -0.963 | 0.963 |
| 143 | CYS | 226 | MET | 2.203 | 3.157 | -0.953 | 0.953 |
| 126 | VAL | 187 | LEU | 0.000 | 0.942 | -0.942 | 0.942 |
| 79 | SER | 447 | SER | 1.773 | 2.712 | -0.939 | 0.939 |
| 51 | VAL | 113 | LEU | 2.377 | 1.444 | 0.933 | 0.933 |
| 101 | ALA | 106 | PRO | 1.384 | 2.308 | -0.924 | 0.924 |
| 117 | TRP | 201 | GLN | 0.417 | 1.340 | -0.923 | 0.923 |
| 408 | CYS | 412 | CYS | 2.693 | 3.612 | -0.920 | 0.920 |
| 205 | ASN | 211 | ILE | 2.625 | 1.711 | 0.914 | 0.914 |
| 73 | VAL | 91 | VAL | 0.389 | 1.302 | -0.913 | 0.913 |
| 120 | GLY | 191 | TYR | 0.912 | 0.000 | 0.912 | 0.912 |
| 79 | SER | 82 | LEU | 2.851 | 1.941 | 0.910 | 0.910 |
| 84 | ALA | 86 | GLN | 1.428 | 2.337 | -0.909 | 0.909 |
| 42 | PRO | 114 | MET | 0.000 | 0.903 | -0.903 | 0.903 |
| 138 | SER | 433 | ASN | 0.898 | 0.000 | 0.898 | 0.898 |
| 209 | TRP | 213 | SER | 0.000 | 0.896 | -0.896 | 0.896 |
| 105 | MET | 427 | TYR | 4.314 | 3.419 | 0.895 | 0.895 |
| 400 | PHE | 404 | LEU | 3.475 | 2.590 | 0.885 | 0.885 |
| 69 | ASN | 97 | ASP | 3.243 | 4.121 | -0.878 | 0.878 |
| 136 | THR | 179 | SER | 4.380 | 3.507 | 0.873 | 0.873 |
| 218 | SER | 399 | PHE | 1.023 | 1.895 | -0.872 | 0.872 |
| 401 | SER | 414 | VAL | 1.453 | 0.588 | 0.865 | 0.865 |
| 118 | TYR | 119 | PHE | 1.221 | 0.359 | 0.862 | 0.862 |
| 150 | TYR | 229 | VAL | 1.962 | 1.118 | 0.844 | 0.844 |
| 215 | CYS | 220 | PHE | 4.107 | 4.944 | -0.837 | 0.837 |
| 104 | VAL | 131 | ASP | 4.363 | 3.528 | 0.835 | 0.835 |
| 71 | LEU | 451 | ILE | 0.206 | 1.039 | -0.833 | 0.833 |
| 328 | ALA | 329 | GLU | 1.364 | 0.540 | 0.824 | 0.824 |
| 193 | GLN | 197 | ALA | 0.009 | 0.831 | -0.821 | 0.821 |
| 226 | MET | 230 | TYR | 0.821 | 0.000 | 0.821 | 0.821 |
| 72 | VAL | 438 | THR | 0.812 | 0.000 | 0.812 | 0.812 |
| 189 | SER | 191 | TYR | 0.805 | 0.000 | 0.805 | 0.805 |
| 394 | CYS | 426 | GLY | 1.151 | 1.955 | -0.804 | 0.804 |
| 89 | PHE | 148 | ASP | 1.348 | 0.545 | 0.803 | 0.803 |
| 45 | GLN | 115 | ALA | 0.000 | 0.803 | -0.803 | 0.803 |
| 64 | PHE | 435 | VAL | 0.324 | 1.127 | -0.802 | 0.802 |
| 220 | PHE | 400 | PHE | 0.000 | 0.800 | -0.800 | 0.800 |
| 72 | VAL | 444 | PHE | 0.498 | 1.286 | -0.788 | 0.788 |
| 438 | THR | 448 | PHE | 3.219 | 2.436 | 0.782 | 0.782 |
| 193 | GLN | 199 | TYR | 0.270 | 1.052 | -0.782 | 0.782 |
| 109 | LEU | 113 | LEU | 3.030 | 2.249 | 0.781 | 0.781 |
| 397 | PRO | 422 | PHE | 6.397 | 7.175 | -0.778 | 0.778 |
| 191 | TYR | 204 | LEU | 0.000 | 0.773 | -0.773 | 0.773 |
| 210 | TYR | 214 | SER | 2.561 | 3.333 | -0.772 | 0.772 |
| 182 | ILE | 218 | SER | 0.767 | 0.000 | 0.767 | 0.767 |
| 155 | GLN | 159 | TYR | 0.000 | 0.767 | -0.767 | 0.767 |
| 10 | LEU | 57 | VAL | 0.000 | 0.767 | -0.767 | 0.767 |
| 43 | ARG | 199 | TYR | 0.761 | 0.000 | 0.761 | 0.761 |
| 232 | ARG | 235 | ARG | 0.757 | 0.000 | 0.757 | 0.757 |
| 394 | CYS | 425 | ILE | 5.391 | 6.144 | -0.753 | 0.753 |
| 117 | TRP | 202 | CYS | 5.785 | 6.534 | -0.749 | 0.749 |
| 198 | ALA | 199 | TYR | 1.350 | 0.603 | 0.747 | 0.747 |
| 193 | GLN | 194 | PRO | 0.233 | 0.979 | -0.746 | 0.746 |
| 72 | VAL | 94 | ALA | 0.035 | 0.774 | -0.740 | 0.740 |
| 96 | ALA | 137 | SER | 1.280 | 0.543 | 0.737 | 0.737 |
| 382 | PHE | 440 | PHE | 0.074 | 0.806 | -0.733 | 0.733 |
| 129 | ALA | 187 | LEU | 0.998 | 1.729 | -0.731 | 0.731 |
| 414 | VAL | 419 | PHE | 0.824 | 1.551 | -0.727 | 0.727 |
| 104 | VAL | 127 | TYR | 2.209 | 2.924 | -0.715 | 0.715 |
| 433 | ASN | 437 | TYR | 0.178 | 0.886 | -0.708 | 0.708 |
| 443 | ASP | 446 | ARG | 0.707 | 0.000 | 0.707 | 0.707 |
| 9 | ALA | 57 | VAL | 0.000 | 0.702 | -0.702 | 0.702 |
| 401 | SER | 422 | PHE | 2.472 | 1.771 | 0.701 | 0.701 |
| 337 | ARG | 338 | SER | 0.000 | 0.699 | -0.699 | 0.699 |
| 62 | ILE | 101 | ALA | 3.087 | 2.391 | 0.696 | 0.696 |
| 276 | CYS | 368 | CYS | 0.000 | 0.695 | -0.695 | 0.695 |
| 41 | PRO | 116 | TYR | 0.000 | 0.692 | -0.692 | 0.692 |
| 142 | LEU | 387 | VAL | 0.000 | 0.691 | -0.691 | 0.691 |
| 390 | VAL | 436 | ILE | 2.046 | 1.358 | 0.689 | 0.689 |
| 142 | LEU | 226 | MET | 2.087 | 2.768 | -0.681 | 0.681 |
| 214 | SER | 218 | SER | 0.802 | 0.125 | 0.676 | 0.676 |
| 230 | TYR | 233 | ILE | 0.539 | 1.213 | -0.674 | 0.674 |
| 127 | TYR | 423 | PHE | 0.242 | 0.911 | -0.669 | 0.669 |
| 211 | ILE | 406 | GLY | 1.327 | 1.996 | -0.669 | 0.669 |
| 423 | PHE | 427 | TYR | 6.146 | 6.812 | -0.666 | 0.666 |
| 398 | PHE | 422 | PHE | 3.252 | 2.588 | 0.664 | 0.664 |
| 219 | PHE | 395 | TRP | 3.169 | 2.505 | 0.664 | 0.664 |
| 121 | GLN | 124 | CYS | 0.000 | 0.663 | -0.663 | 0.663 |
| 208 | THR | 406 | GLY | 3.841 | 4.497 | -0.656 | 0.656 |
| 233 | ILE | 381 | THR | 0.000 | 0.654 | -0.654 | 0.654 |
| 41 | PRO | 420 | LYS | 0.649 | 0.000 | 0.649 | 0.649 |
| 58 | VAL | 109 | LEU | 2.247 | 2.891 | -0.643 | 0.643 |
| 147 | LEU | 151 | TRP | 1.492 | 2.132 | -0.639 | 0.639 |
| 380 | PHE | 441 | ASN | 0.000 | 0.635 | -0.635 | 0.635 |
| 392 | VAL | 397 | PRO | 0.682 | 0.049 | 0.633 | 0.633 |
| 204 | LEU | 398 | PHE | 0.358 | 0.987 | -0.630 | 0.630 |
| 116 | TYR | 200 | PRO | 1.930 | 2.559 | -0.629 | 0.629 |
| 46 | TYR | 51 | VAL | 1.250 | 1.877 | -0.626 | 0.626 |
| 447 | SER | 451 | ILE | 0.626 | 0.000 | 0.626 | 0.626 |
| 65 | THR | 430 | SER | 2.318 | 2.943 | -0.625 | 0.625 |
| 54 | LEU | 112 | GLU | 0.000 | 0.613 | -0.613 | 0.613 |
| 127 | TYR | 427 | TYR | 0.193 | 0.803 | -0.610 | 0.610 |
| 136 | THR | 183 | SER | 0.606 | 0.000 | 0.606 | 0.606 |
| 159 | TYR | 167 | ARG | 0.600 | 0.000 | 0.600 | 0.600 |
| 190 | LEU | 202 | CYS | 0.599 | 0.000 | 0.599 | 0.599 |
| 78 | THR | 451 | ILE | 0.786 | 0.187 | 0.598 | 0.598 |
| 97 | ASP | 433 | ASN | 4.357 | 3.760 | 0.597 | 0.597 |
| 148 | ASP | 159 | TYR | 5.683 | 5.086 | 0.597 | 0.597 |
| 205 | ASN | 210 | TYR | 4.492 | 5.088 | -0.596 | 0.596 |
| 266 | ALA | 267 | ALA | 0.596 | 0.000 | 0.596 | 0.596 |
| 124 | CYS | 191 | TYR | 0.596 | 0.000 | 0.596 | 0.596 |
| 55 | ALA | 109 | LEU | 1.247 | 0.656 | 0.591 | 0.591 |
| 90 | LEU | 380 | PHE | 0.000 | 0.585 | -0.585 | 0.585 |
| 293 | GLU | 297 | ARG | 0.577 | 0.000 | 0.577 | 0.577 |
| 85 | PRO | 86 | GLN | 0.000 | 0.575 | -0.575 | 0.575 |
| 149 | ARG | 381 | THR | 0.000 | 0.572 | -0.572 | 0.572 |
| 393 | LEU | 425 | ILE | 0.571 | 0.000 | 0.571 | 0.571 |
| 6 | LEU | 50 | ALA | 0.000 | 0.570 | -0.570 | 0.570 |
| 223 | CYS | 226 | MET | 0.000 | 0.566 | -0.566 | 0.566 |
| 65 | THR | 431 | SER | 4.828 | 4.262 | 0.566 | 0.566 |
| 395 | TRP | 399 | PHE | 2.840 | 3.403 | -0.563 | 0.563 |
| 6 | LEU | 54 | LEU | 0.000 | 0.559 | -0.559 | 0.559 |
| 75 | ALA | 82 | LEU | 2.231 | 2.789 | -0.559 | 0.559 |
| 418 | LEU | 422 | PHE | 4.282 | 3.729 | 0.553 | 0.553 |
| 75 | ALA | 444 | PHE | 0.286 | 0.837 | -0.551 | 0.551 |
| 146 | SER | 229 | VAL | 2.718 | 2.170 | 0.547 | 0.547 |
| 398 | PHE | 419 | PHE | 1.652 | 2.197 | -0.545 | 0.545 |
| 248 | ARG | 366 | SER | 0.544 | 0.000 | 0.544 | 0.544 |
| 12 | VAL | 428 | CYS | 0.000 | 0.544 | -0.544 | 0.544 |
| 72 | VAL | 434 | PRO | 1.370 | 0.828 | 0.542 | 0.542 |
| 85 | PRO | 165 | PRO | 0.814 | 1.355 | -0.541 | 0.541 |
| 382 | PHE | 386 | VAL | 2.307 | 1.771 | 0.536 | 0.536 |
| 182 | ILE | 214 | SER | 0.534 | 0.000 | 0.534 | 0.534 |
| 143 | CYS | 222 | PRO | 1.361 | 1.893 | -0.531 | 0.531 |
| 392 | VAL | 396 | PHE | 0.601 | 0.071 | 0.530 | 0.530 |
| 96 | ALA | 138 | SER | 0.226 | 0.750 | -0.525 | 0.525 |
| 335 | ALA | 336 | SER | 0.524 | 0.000 | 0.524 | 0.524 |
| 215 | CYS | 399 | PHE | 2.193 | 1.671 | 0.522 | 0.522 |
| 89 | PHE | 144 | ALA | 0.260 | 0.781 | -0.521 | 0.521 |
| 139 | ILE | 226 | MET | 0.000 | 0.520 | -0.520 | 0.520 |
| 114 | MET | 119 | PHE | 0.000 | 0.518 | -0.518 | 0.518 |
| 186 | PRO | 210 | TYR | 1.623 | 2.140 | -0.518 | 0.518 |
| 436 | ILE | 440 | PHE | 0.000 | 0.517 | -0.517 | 0.517 |
| 186 | PRO | 209 | TRP | 0.517 | 0.000 | 0.517 | 0.517 |
| 149 | ARG | 233 | ILE | 0.531 | 1.046 | -0.515 | 0.515 |
| 108 | SER | 423 | PHE | 0.822 | 0.309 | 0.514 | 0.514 |
| 145 | ILE | 437 | TYR | 0.512 | 0.000 | 0.512 | 0.512 |
| 62 | ILE | 105 | MET | 2.007 | 2.518 | -0.511 | 0.511 |
| 205 | ASN | 207 | GLU | 3.138 | 2.628 | 0.510 | 0.510 |
| 220 | PHE | 396 | PHE | 0.008 | 0.517 | -0.509 | 0.509 |
| 216 | ILE | 221 | ALA | 2.775 | 3.284 | -0.509 | 0.509 |
| 452 | LEU | 453 | PHE | 0.186 | 0.694 | -0.508 | 0.508 |
| 66 | VAL | 98 | ILE | 0.116 | 0.622 | -0.506 | 0.506 |
| 136 | THR | 140 | VAL | 0.000 | 0.504 | -0.504 | 0.504 |
| 223 | CYS | 392 | VAL | 0.369 | 0.869 | -0.500 | 0.500 |
| 217 | GLY | 222 | PRO | 1.892 | 2.391 | -0.499 | 0.499 |
| 133 | LEU | 134 | PHE | 1.130 | 1.628 | -0.498 | 0.498 |
| 387 | VAL | 436 | ILE | 1.616 | 2.109 | -0.493 | 0.493 |
| 117 | TRP | 124 | CYS | 5.777 | 6.263 | -0.487 | 0.487 |
| 131 | ASP | 135 | CYS | 1.031 | 1.518 | -0.487 | 0.487 |
| 108 | SER | 127 | TYR | 6.221 | 5.735 | 0.486 | 0.486 |
| 93 | LEU | 433 | ASN | 0.412 | 0.898 | -0.486 | 0.486 |
| 68 | GLY | 448 | PHE | 0.000 | 0.486 | -0.486 | 0.486 |
| 72 | VAL | 90 | LEU | 0.000 | 0.478 | -0.478 | 0.478 |
| 13 | ALA | 57 | VAL | 0.000 | 0.476 | -0.476 | 0.476 |
| 226 | MET | 388 | MET | 0.953 | 0.478 | 0.474 | 0.474 |
| 82 | LEU | 447 | SER | 1.044 | 1.518 | -0.474 | 0.474 |
| 132 | VAL | 182 | ILE | 0.000 | 0.471 | -0.471 | 0.471 |
| 216 | ILE | 222 | PRO | 0.308 | 0.779 | -0.471 | 0.471 |
| 96 | ALA | 134 | PHE | 0.355 | 0.824 | -0.470 | 0.470 |
| 9 | ALA | 421 | PHE | 0.000 | 0.469 | -0.469 | 0.469 |
| 135 | CYS | 395 | TRP | 1.821 | 2.285 | -0.464 | 0.464 |
| 390 | VAL | 432 | LEU | 0.771 | 1.231 | -0.460 | 0.460 |
| 117 | TRP | 191 | TYR | 0.457 | 0.000 | 0.457 | 0.457 |
| 230 | TYR | 437 | TYR | 0.457 | 0.000 | 0.457 | 0.457 |
| 85 | PRO | 168 | VAL | 2.342 | 2.799 | -0.457 | 0.457 |
| 139 | ILE | 219 | PHE | 0.000 | 0.453 | -0.453 | 0.453 |
| 116 | TYR | 118 | TYR | 1.069 | 1.517 | -0.447 | 0.447 |
| 152 | SER | 159 | TYR | 2.186 | 2.631 | -0.445 | 0.445 |
| 194 | PRO | 201 | GLN | 0.442 | 0.000 | 0.442 | 0.442 |
| 260 | THR | 261 | GLU | 0.440 | 0.000 | 0.440 | 0.440 |
| 125 | GLY | 186 | PRO | 0.000 | 0.435 | -0.435 | 0.435 |
| 61 | LEU | 428 | CYS | 0.955 | 0.520 | 0.435 | 0.435 |
| 110 | ALA | 114 | MET | 0.000 | 0.435 | -0.435 | 0.435 |
| 133 | LEU | 179 | SER | 3.239 | 2.805 | 0.434 | 0.434 |
| 182 | ILE | 217 | GLY | 0.431 | 0.000 | 0.431 | 0.431 |
| 90 | LEU | 384 | LEU | 0.000 | 0.431 | -0.431 | 0.431 |
| 46 | TYR | 50 | ALA | 0.419 | 0.847 | -0.429 | 0.429 |
| 33 | ASN | 35 | SER | 0.426 | 0.000 | 0.426 | 0.426 |
| 133 | LEU | 176 | TRP | 0.184 | 0.609 | -0.424 | 0.424 |
| 450 | HIS | 455 | ARG | 0.000 | 0.424 | -0.424 | 0.424 |
| 352 | SER | 353 | VAL | 0.000 | 0.422 | -0.422 | 0.422 |
| 183 | SER | 210 | TYR | 0.420 | 0.000 | 0.420 | 0.420 |
| 206 | ASP | 211 | ILE | 1.876 | 2.293 | -0.417 | 0.417 |
| 128 | LEU | 186 | PRO | 0.000 | 0.416 | -0.416 | 0.416 |
| 163 | ARG | 168 | VAL | 0.000 | 0.415 | -0.415 | 0.415 |
| 104 | VAL | 427 | TYR | 1.911 | 2.321 | -0.410 | 0.410 |
| 54 | LEU | 113 | LEU | 0.526 | 0.937 | -0.410 | 0.410 |
| 407 | ILE | 408 | CYS | 0.946 | 0.536 | 0.410 | 0.410 |
| 398 | PHE | 423 | PHE | 3.457 | 3.048 | 0.409 | 0.409 |
| 184 | PHE | 185 | PRO | 1.102 | 0.698 | 0.404 | 0.404 |
| 92 | SER | 95 | SER | 0.396 | 0.000 | 0.396 | 0.396 |
| 90 | LEU | 145 | ILE | 0.763 | 0.368 | 0.396 | 0.396 |
| 219 | PHE | 396 | PHE | 4.719 | 4.323 | 0.395 | 0.395 |
| 153 | VAL | 233 | ILE | 0.000 | 0.393 | -0.393 | 0.393 |
| 135 | CYS | 427 | TYR | 0.418 | 0.025 | 0.393 | 0.393 |
| 128 | LEU | 203 | GLY | 2.513 | 2.121 | 0.393 | 0.393 |
| 71 | LEU | 452 | LEU | 0.012 | 0.403 | -0.391 | 0.391 |
| 131 | ASP | 423 | PHE | 1.142 | 1.531 | -0.390 | 0.390 |
| 100 | VAL | 427 | TYR | 1.480 | 1.094 | 0.386 | 0.386 |
| 62 | ILE | 106 | PRO | 0.757 | 1.140 | -0.383 | 0.383 |
| 144 | ALA | 171 | THR | 0.000 | 0.382 | -0.382 | 0.382 |
| 249 | ALA | 250 | PRO | 0.056 | 0.437 | -0.381 | 0.381 |
| 224 | LEU | 228 | LEU | 0.961 | 1.340 | -0.379 | 0.379 |
| 256 | ALA | 257 | SER | 0.379 | 0.000 | 0.379 | 0.379 |
| 142 | LEU | 429 | ASN | 0.379 | 0.000 | 0.379 | 0.379 |
| 383 | VAL | 437 | TYR | 0.000 | 0.378 | -0.378 | 0.378 |
| 218 | SER | 219 | PHE | 0.000 | 0.378 | -0.378 | 0.378 |
| 97 | ASP | 430 | SER | 9.447 | 9.824 | -0.377 | 0.377 |
| 92 | SER | 172 | ILE | 2.108 | 2.484 | -0.375 | 0.375 |
| 70 | VAL | 98 | ILE | 1.351 | 1.720 | -0.370 | 0.370 |
| 149 | ARG | 230 | TYR | 0.396 | 0.763 | -0.366 | 0.366 |
| 93 | LEU | 145 | ILE | 0.535 | 0.170 | 0.365 | 0.365 |
| 374 | GLN | 378 | LYS | 0.364 | 0.000 | 0.364 | 0.364 |
| 146 | SER | 233 | ILE | 0.191 | 0.553 | -0.362 | 0.362 |
| 193 | GLN | 198 | ALA | 0.358 | 0.000 | 0.358 | 0.358 |
| 190 | LEU | 192 | ARG | 0.355 | 0.000 | 0.355 | 0.355 |
| 157 | VAL | 161 | LEU | 0.000 | 0.355 | -0.355 | 0.355 |
| 383 | VAL | 441 | ASN | 0.000 | 0.351 | -0.351 | 0.351 |
| 132 | VAL | 210 | TYR | 0.347 | 0.000 | 0.347 | 0.347 |
| 95 | SER | 176 | TRP | 0.344 | 0.000 | 0.344 | 0.344 |
| 124 | CYS | 202 | CYS | 6.380 | 6.722 | -0.342 | 0.342 |
| 105 | MET | 424 | TRP | 0.346 | 0.688 | -0.342 | 0.342 |
| 358 | SER | 362 | ARG | 0.000 | 0.341 | -0.341 | 0.341 |
| 90 | LEU | 437 | TYR | 1.513 | 1.172 | 0.341 | 0.341 |
| 93 | LEU | 437 | TYR | 0.341 | 0.680 | -0.339 | 0.339 |
| 241 | THR | 373 | ALA | 0.339 | 0.000 | 0.339 | 0.339 |
| 143 | CYS | 147 | LEU | 0.334 | 0.000 | 0.334 | 0.334 |
| 204 | LEU | 419 | PHE | 0.919 | 0.585 | 0.334 | 0.334 |
| 284 | GLU | 285 | PRO | 0.495 | 0.829 | -0.334 | 0.334 |
| 127 | TYR | 202 | CYS | 0.320 | 0.647 | -0.327 | 0.327 |
| 86 | GLN | 380 | PHE | 0.000 | 0.327 | -0.327 | 0.327 |
| 137 | SER | 175 | VAL | 0.285 | 0.609 | -0.324 | 0.324 |
| 402 | TYR | 419 | PHE | 1.348 | 1.025 | 0.323 | 0.323 |
| 215 | CYS | 403 | SER | 1.680 | 2.001 | -0.321 | 0.321 |
| 234 | TYR | 238 | LYS | 3.172 | 3.493 | -0.321 | 0.321 |
| 150 | TYR | 232 | ARG | 0.928 | 0.611 | 0.317 | 0.317 |
| 367 | VAL | 371 | LYS | 0.170 | 0.484 | -0.315 | 0.315 |
| 336 | SER | 337 | ARG | 0.314 | 0.000 | 0.314 | 0.314 |
| 105 | MET | 430 | SER | 0.000 | 0.315 | -0.314 | 0.314 |
| 441 | ASN | 443 | ASP | 1.746 | 1.433 | 0.313 | 0.313 |
| 133 | LEU | 180 | ALA | 2.010 | 1.700 | 0.311 | 0.311 |
| 394 | CYS | 422 | PHE | 0.059 | 0.368 | -0.309 | 0.309 |
| 69 | ASN | 72 | VAL | 0.000 | 0.300 | -0.300 | 0.300 |
| 60 | PHE | 64 | PHE | 0.087 | 0.387 | -0.300 | 0.300 |
| 156 | ALA | 240 | ARG | 0.000 | 0.299 | -0.299 | 0.299 |
| 454 | ARG | 458 | ARG | 0.299 | 0.000 | 0.299 | 0.299 |
| 159 | TYR | 163 | ARG | 1.023 | 1.322 | -0.299 | 0.299 |
| 436 | ILE | 437 | TYR | 0.298 | 0.000 | 0.298 | 0.298 |
| 394 | CYS | 432 | LEU | 0.157 | 0.452 | -0.295 | 0.295 |
| 69 | ASN | 433 | ASN | 0.000 | 0.294 | -0.294 | 0.294 |
| 39 | TRP | 420 | LYS | 0.294 | 0.000 | 0.294 | 0.294 |
| 436 | ILE | 441 | ASN | 0.000 | 0.286 | -0.286 | 0.286 |
| 391 | PHE | 392 | VAL | 0.286 | 0.000 | 0.286 | 0.286 |
| 88 | LEU | 165 | PRO | 0.000 | 0.281 | -0.281 | 0.281 |
| 372 | VAL | 376 | ARG | 0.000 | 0.280 | -0.280 | 0.280 |
| 141 | HIS | 172 | ILE | 0.366 | 0.645 | -0.279 | 0.279 |
| 67 | VAL | 71 | LEU | 0.558 | 0.279 | 0.279 | 0.279 |
| 139 | ILE | 218 | SER | 3.079 | 3.356 | -0.276 | 0.276 |
| 128 | LEU | 204 | LEU | 0.619 | 0.349 | 0.270 | 0.270 |
| 93 | LEU | 97 | ASP | 0.848 | 0.579 | 0.269 | 0.269 |
| 130 | LEU | 134 | PHE | 1.779 | 2.048 | -0.269 | 0.269 |
| 99 | LEU | 104 | VAL | 0.631 | 0.897 | -0.267 | 0.267 |
| 211 | ILE | 403 | SER | 0.148 | 0.411 | -0.263 | 0.263 |
| 449 | LYS | 454 | ARG | 0.130 | 0.392 | -0.263 | 0.263 |
| 150 | TYR | 151 | TRP | 1.552 | 1.813 | -0.262 | 0.262 |
| 89 | PHE | 145 | ILE | 1.883 | 2.143 | -0.260 | 0.260 |
| 85 | PRO | 163 | ARG | 0.903 | 1.162 | -0.258 | 0.258 |
| 147 | LEU | 229 | VAL | 0.816 | 0.558 | 0.258 | 0.258 |
| 99 | LEU | 103 | LEU | 0.564 | 0.820 | -0.256 | 0.256 |
| 66 | VAL | 101 | ALA | 0.490 | 0.745 | -0.255 | 0.255 |
| 137 | SER | 179 | SER | 4.087 | 4.342 | -0.255 | 0.255 |
| 386 | VAL | 440 | PHE | 0.206 | 0.460 | -0.254 | 0.254 |
| 104 | VAL | 134 | PHE | 0.897 | 0.648 | 0.248 | 0.248 |
| 146 | SER | 147 | LEU | 0.237 | 0.000 | 0.237 | 0.237 |
| 216 | ILE | 220 | PHE | 0.236 | 0.000 | 0.236 | 0.236 |
| 155 | GLN | 160 | ASN | 0.060 | 0.295 | -0.236 | 0.236 |
| 140 | VAL | 179 | SER | 0.361 | 0.596 | -0.235 | 0.235 |
| 54 | LEU | 58 | VAL | 0.530 | 0.764 | -0.235 | 0.235 |
| 327 | ALA | 328 | ALA | 0.231 | 0.000 | 0.231 | 0.231 |
| 124 | CYS | 128 | LEU | 0.615 | 0.845 | -0.230 | 0.230 |
| 75 | ALA | 448 | PHE | 1.444 | 1.216 | 0.228 | 0.228 |
| 441 | ASN | 444 | PHE | 3.362 | 3.138 | 0.225 | 0.225 |
| 25 | GLU | 26 | ARG | 0.225 | 0.000 | 0.225 | 0.225 |
| 76 | VAL | 91 | VAL | 1.621 | 1.842 | -0.220 | 0.220 |
| 89 | PHE | 168 | VAL | 3.863 | 3.642 | 0.220 | 0.220 |
| 75 | ALA | 451 | ILE | 1.858 | 1.637 | 0.220 | 0.220 |
| 432 | LEU | 436 | ILE | 0.453 | 0.233 | 0.220 | 0.220 |
| 414 | VAL | 415 | PRO | 1.314 | 1.096 | 0.218 | 0.218 |
| 127 | TYR | 131 | ASP | 0.218 | 0.000 | 0.218 | 0.218 |
| 429 | ASN | 430 | SER | 0.000 | 0.218 | -0.218 | 0.218 |
| 140 | VAL | 178 | ILE | 0.000 | 0.218 | -0.218 | 0.218 |
| 18 | PRO | 19 | ASN | 0.000 | 0.218 | -0.218 | 0.218 |
| 155 | GLN | 158 | GLU | 0.217 | 0.000 | 0.217 | 0.217 |
| 127 | TYR | 128 | LEU | 1.576 | 1.361 | 0.215 | 0.215 |
| 396 | PHE | 397 | PRO | 1.082 | 1.294 | -0.212 | 0.212 |
| 128 | LEU | 202 | CYS | 1.026 | 1.238 | -0.212 | 0.212 |
| 390 | VAL | 429 | ASN | 0.929 | 1.141 | -0.212 | 0.212 |
| 45 | GLN | 420 | LYS | 0.000 | 0.211 | -0.211 | 0.211 |
| 138 | SER | 430 | SER | 0.211 | 0.000 | 0.211 | 0.211 |
| 110 | ALA | 119 | PHE | 0.759 | 0.970 | -0.211 | 0.211 |
| 211 | ILE | 215 | CYS | 0.391 | 0.182 | 0.209 | 0.209 |
| 100 | VAL | 430 | SER | 0.061 | 0.269 | -0.208 | 0.208 |
| 61 | LEU | 431 | SER | 0.443 | 0.238 | 0.205 | 0.205 |
| 3 | SER | 46 | TYR | 0.000 | 0.204 | -0.204 | 0.204 |
| 151 | TRP | 154 | THR | 0.000 | 0.202 | -0.202 | 0.202 |
| 64 | PHE | 431 | SER | 2.230 | 2.028 | 0.202 | 0.202 |
| 211 | ILE | 405 | TYR | 0.445 | 0.647 | -0.202 | 0.202 |
| 45 | GLN | 46 | TYR | 0.000 | 0.201 | -0.201 | 0.201 |
| 88 | LEU | 172 | ILE | 2.409 | 2.210 | 0.199 | 0.199 |
| 103 | LEU | 134 | PHE | 1.060 | 1.259 | -0.199 | 0.199 |
| 65 | THR | 105 | MET | 0.068 | 0.266 | -0.198 | 0.198 |
| 62 | ILE | 66 | VAL | 0.193 | 0.000 | 0.193 | 0.193 |
| 100 | VAL | 106 | PRO | 0.000 | 0.192 | -0.192 | 0.192 |
| 112 | GLU | 420 | LYS | 8.663 | 8.472 | 0.192 | 0.192 |
| 377 | GLU | 381 | THR | 0.264 | 0.076 | 0.187 | 0.187 |
| 57 | VAL | 61 | LEU | 0.214 | 0.401 | -0.187 | 0.187 |
| 132 | VAL | 214 | SER | 0.185 | 0.000 | 0.185 | 0.185 |
| 132 | VAL | 186 | PRO | 0.000 | 0.184 | -0.184 | 0.184 |
| 86 | GLN | 168 | VAL | 0.000 | 0.184 | -0.184 | 0.184 |
| 6 | LEU | 10 | LEU | 0.000 | 0.184 | -0.184 | 0.184 |
| 100 | VAL | 104 | VAL | 0.065 | 0.249 | -0.183 | 0.183 |
| 66 | VAL | 70 | VAL | 0.374 | 0.191 | 0.183 | 0.183 |
| 421 | PHE | 422 | PHE | 0.913 | 0.731 | 0.181 | 0.181 |
| 153 | VAL | 381 | THR | 0.000 | 0.180 | -0.180 | 0.180 |
| 383 | VAL | 387 | VAL | 0.177 | 0.000 | 0.177 | 0.177 |
| 219 | PHE | 391 | PHE | 1.225 | 1.049 | 0.176 | 0.176 |
| 267 | ALA | 268 | ALA | 0.176 | 0.000 | 0.176 | 0.176 |
| 65 | THR | 97 | ASP | 1.007 | 0.832 | 0.175 | 0.175 |
| 214 | SER | 219 | PHE | 0.034 | 0.209 | -0.174 | 0.174 |
| 220 | PHE | 403 | SER | 1.624 | 1.451 | 0.172 | 0.172 |
| 98 | ILE | 102 | THR | 0.448 | 0.277 | 0.171 | 0.171 |
| 311 | ALA | 312 | GLU | 0.119 | 0.289 | -0.171 | 0.171 |
| 146 | SER | 226 | MET | 1.850 | 2.021 | -0.171 | 0.171 |
| 404 | LEU | 408 | CYS | 0.000 | 0.169 | -0.169 | 0.169 |
| 444 | PHE | 448 | PHE | 0.954 | 0.786 | 0.168 | 0.168 |
| 82 | LEU | 443 | ASP | 0.992 | 1.158 | -0.166 | 0.166 |
| 138 | SER | 391 | PHE | 0.000 | 0.165 | -0.165 | 0.165 |
| 338 | SER | 339 | PRO | 0.592 | 0.428 | 0.164 | 0.164 |
| 100 | VAL | 135 | CYS | 0.315 | 0.155 | 0.160 | 0.160 |
| 229 | VAL | 233 | ILE | 0.776 | 0.618 | 0.158 | 0.158 |
| 85 | PRO | 164 | THR | 0.046 | 0.202 | -0.156 | 0.156 |
| 3 | SER | 5 | ALA | 0.290 | 0.135 | 0.155 | 0.155 |
| 76 | VAL | 444 | PHE | 1.381 | 1.228 | 0.154 | 0.154 |
| 388 | MET | 391 | PHE | 0.153 | 0.000 | 0.153 | 0.153 |
| 134 | PHE | 137 | SER | 0.152 | 0.000 | 0.152 | 0.152 |
| 438 | THR | 439 | VAL | 0.000 | 0.151 | -0.151 | 0.151 |
| 346 | SER | 348 | ALA | 0.000 | 0.150 | -0.150 | 0.150 |
| 192 | ARG | 194 | PRO | 0.150 | 0.000 | 0.150 | 0.150 |
| 102 | THR | 103 | LEU | 0.781 | 0.930 | -0.148 | 0.148 |
| 82 | LEU | 87 | ASN | 5.603 | 5.751 | -0.148 | 0.148 |
| 97 | ASP | 429 | ASN | 0.000 | 0.148 | -0.148 | 0.148 |
| 151 | TRP | 156 | ALA | 0.668 | 0.521 | 0.147 | 0.147 |
| 171 | THR | 175 | VAL | 0.032 | 0.176 | -0.144 | 0.144 |
| 88 | LEU | 168 | VAL | 0.797 | 0.656 | 0.141 | 0.141 |
| 435 | VAL | 439 | VAL | 0.134 | 0.275 | -0.141 | 0.141 |
| 199 | TYR | 201 | GLN | 0.000 | 0.138 | -0.138 | 0.138 |
| 229 | VAL | 230 | TYR | 0.166 | 0.031 | 0.136 | 0.136 |
| 199 | TYR | 200 | PRO | 0.850 | 0.715 | 0.135 | 0.135 |
| 79 | SER | 81 | ALA | 0.650 | 0.517 | 0.134 | 0.134 |
| 89 | PHE | 141 | HIS | 0.366 | 0.500 | -0.133 | 0.133 |
| 63 | VAL | 67 | VAL | 0.337 | 0.204 | 0.133 | 0.133 |
| 112 | GLU | 424 | TRP | 0.014 | 0.147 | -0.133 | 0.133 |
| 415 | PRO | 417 | PRO | 0.291 | 0.161 | 0.131 | 0.131 |
| 164 | THR | 165 | PRO | 0.779 | 0.908 | -0.129 | 0.129 |
| 248 | ARG | 362 | ARG | 0.129 | 0.000 | 0.129 | 0.129 |
| 101 | ALA | 105 | MET | 0.587 | 0.715 | -0.128 | 0.128 |
| 384 | LEU | 388 | MET | 0.000 | 0.123 | -0.123 | 0.123 |
| 65 | THR | 69 | ASN | 0.852 | 0.729 | 0.123 | 0.123 |
| 58 | VAL | 62 | ILE | 0.610 | 0.733 | -0.123 | 0.123 |
| 226 | MET | 437 | TYR | 0.122 | 0.000 | 0.122 | 0.122 |
| 144 | ALA | 175 | VAL | 0.357 | 0.478 | -0.121 | 0.121 |
| 89 | PHE | 171 | THR | 2.162 | 2.282 | -0.120 | 0.120 |
| 142 | LEU | 145 | ILE | 0.000 | 0.118 | -0.118 | 0.118 |
| 42 | PRO | 115 | ALA | 0.000 | 0.118 | -0.118 | 0.118 |
| 37 | ALA | 410 | GLU | 0.118 | 0.000 | 0.118 | 0.118 |
| 351 | ARG | 354 | GLU | 0.000 | 0.117 | -0.117 | 0.117 |
| 212 | LEU | 407 | ILE | 1.079 | 0.964 | 0.115 | 0.115 |
| 55 | ALA | 113 | LEU | 0.321 | 0.436 | -0.115 | 0.115 |
| 41 | PRO | 42 | PRO | 0.678 | 0.792 | -0.114 | 0.114 |
| 47 | SER | 50 | ALA | 0.791 | 0.678 | 0.114 | 0.114 |
| 74 | ILE | 79 | SER | 0.000 | 0.114 | -0.114 | 0.114 |
| 87 | ASN | 90 | LEU | 0.435 | 0.548 | -0.113 | 0.113 |
| 107 | PHE | 117 | TRP | 0.742 | 0.853 | -0.111 | 0.111 |
| 69 | ASN | 98 | ILE | 2.068 | 1.958 | 0.110 | 0.110 |
| 117 | TRP | 119 | PHE | 3.296 | 3.406 | -0.109 | 0.109 |
| 124 | CYS | 190 | LEU | 0.108 | 0.000 | 0.108 | 0.108 |
| 405 | TYR | 412 | CYS | 0.000 | 0.107 | -0.107 | 0.107 |
| 103 | LEU | 127 | TYR | 0.000 | 0.107 | -0.107 | 0.107 |
| 208 | THR | 212 | LEU | 0.523 | 0.418 | 0.105 | 0.105 |
| 103 | LEU | 130 | LEU | 0.000 | 0.105 | -0.105 | 0.105 |
| 88 | LEU | 169 | LYS | 0.308 | 0.204 | 0.104 | 0.104 |
| 191 | TYR | 193 | GLN | 0.000 | 0.103 | -0.103 | 0.103 |
| 414 | VAL | 418 | LEU | 1.763 | 1.660 | 0.103 | 0.103 |
| 225 | ILE | 229 | VAL | 0.294 | 0.191 | 0.103 | 0.103 |
| 239 | LEU | 243 | THR | 0.000 | 0.102 | -0.102 | 0.102 |
| 99 | LEU | 102 | THR | 0.000 | 0.099 | -0.099 | 0.099 |
| 54 | LEU | 109 | LEU | 0.761 | 0.662 | 0.099 | 0.099 |
| 151 | TRP | 155 | GLN | 0.298 | 0.200 | 0.098 | 0.098 |
| 215 | CYS | 402 | TYR | 1.349 | 1.446 | -0.097 | 0.097 |
| 394 | CYS | 395 | TRP | 0.121 | 0.218 | -0.097 | 0.097 |
| 74 | ILE | 78 | THR | 0.706 | 0.802 | -0.096 | 0.096 |
| 387 | VAL | 437 | TYR | 1.308 | 1.212 | 0.095 | 0.095 |
| 128 | LEU | 190 | LEU | 0.094 | 0.000 | 0.094 | 0.094 |
| 80 | ARG | 83 | ARG | 0.093 | 0.000 | 0.093 | 0.093 |
| 391 | PHE | 396 | PHE | 0.091 | 0.000 | 0.091 | 0.091 |
| 237 | ALA | 378 | LYS | 0.000 | 0.088 | -0.088 | 0.088 |
| 93 | LEU | 138 | SER | 2.805 | 2.717 | 0.088 | 0.088 |
| 54 | LEU | 59 | GLY | 0.000 | 0.086 | -0.086 | 0.086 |
| 209 | TRP | 210 | TYR | 2.456 | 2.538 | -0.083 | 0.083 |
| 58 | VAL | 105 | MET | 0.082 | 0.000 | 0.082 | 0.082 |
| 221 | ALA | 222 | PRO | 0.908 | 0.827 | 0.081 | 0.081 |
| 293 | GLU | 296 | ARG | 0.000 | 0.081 | -0.081 | 0.081 |
| 107 | PHE | 119 | PHE | 4.462 | 4.543 | -0.081 | 0.081 |
| 86 | GLN | 87 | ASN | 2.278 | 2.358 | -0.080 | 0.080 |
| 126 | VAL | 130 | LEU | 0.783 | 0.863 | -0.080 | 0.080 |
| 431 | SER | 432 | LEU | 0.818 | 0.739 | 0.079 | 0.079 |
| 90 | LEU | 93 | LEU | 0.076 | 0.000 | 0.076 | 0.076 |
| 84 | ALA | 85 | PRO | 0.660 | 0.585 | 0.075 | 0.075 |
| 132 | VAL | 136 | THR | 0.457 | 0.532 | -0.075 | 0.075 |
| 206 | ASP | 409 | ARG | 0.000 | 0.075 | -0.075 | 0.075 |
| 210 | TYR | 213 | SER | 0.000 | 0.074 | -0.074 | 0.074 |
| 104 | VAL | 108 | SER | 0.620 | 0.546 | 0.074 | 0.074 |
| 92 | SER | 141 | HIS | 6.082 | 6.010 | 0.073 | 0.073 |
| 173 | VAL | 177 | LEU | 0.777 | 0.706 | 0.071 | 0.071 |
| 350 | SER | 351 | ARG | 0.000 | 0.071 | -0.071 | 0.071 |
| 236 | VAL | 240 | ARG | 1.188 | 1.258 | -0.071 | 0.071 |
| 363 | ALA | 366 | SER | 0.070 | 0.000 | 0.070 | 0.070 |
| 66 | VAL | 102 | THR | 0.670 | 0.600 | 0.070 | 0.070 |
| 131 | ASP | 136 | THR | 0.000 | 0.069 | -0.069 | 0.069 |
| 154 | THR | 236 | VAL | 0.108 | 0.177 | -0.068 | 0.068 |
| 390 | VAL | 394 | CYS | 0.484 | 0.417 | 0.067 | 0.067 |
| 78 | THR | 447 | SER | 0.067 | 0.000 | 0.067 | 0.067 |
| 366 | SER | 367 | VAL | 0.000 | 0.066 | -0.066 | 0.066 |
| 84 | ALA | 87 | ASN | 0.370 | 0.434 | -0.064 | 0.064 |
| 3 | SER | 6 | LEU | 0.000 | 0.063 | -0.063 | 0.063 |
| 277 | ALA | 278 | PRO | 0.485 | 0.546 | -0.061 | 0.061 |
| 353 | VAL | 357 | LEU | 0.830 | 0.770 | 0.060 | 0.060 |
| 99 | LEU | 176 | TRP | 0.307 | 0.365 | -0.058 | 0.058 |
| 72 | VAL | 76 | VAL | 0.057 | 0.000 | 0.057 | 0.057 |
| 368 | CYS | 372 | VAL | 0.158 | 0.102 | 0.057 | 0.057 |
| 184 | PHE | 187 | LEU | 0.803 | 0.860 | -0.057 | 0.057 |
| 424 | TRP | 427 | TYR | 1.332 | 1.389 | -0.057 | 0.057 |
| 430 | SER | 433 | ASN | 0.056 | 0.000 | 0.056 | 0.056 |
| 408 | CYS | 411 | ALA | 0.121 | 0.177 | -0.056 | 0.056 |
| 104 | VAL | 130 | LEU | 0.607 | 0.661 | -0.054 | 0.054 |
| 3 | SER | 417 | PRO | 0.000 | 0.053 | -0.053 | 0.053 |
| 86 | GLN | 89 | PHE | 0.000 | 0.052 | -0.052 | 0.052 |
| 439 | VAL | 440 | PHE | 3.697 | 3.646 | 0.052 | 0.052 |
| 130 | LEU | 133 | LEU | 0.256 | 0.205 | 0.050 | 0.050 |
| 160 | ASN | 377 | GLU | 0.000 | 0.050 | -0.050 | 0.050 |
| 121 | GLN | 201 | GLN | 0.000 | 0.049 | -0.049 | 0.049 |
| 428 | CYS | 431 | SER | 0.096 | 0.146 | -0.049 | 0.049 |
| 414 | VAL | 422 | PHE | 0.322 | 0.275 | 0.048 | 0.048 |
| 355 | PHE | 358 | SER | 0.045 | 0.000 | 0.045 | 0.045 |
| 143 | CYS | 146 | SER | 0.044 | 0.000 | 0.044 | 0.044 |
| 168 | VAL | 172 | ILE | 0.576 | 0.532 | 0.044 | 0.044 |
| 110 | ALA | 116 | TYR | 0.044 | 0.000 | 0.044 | 0.044 |
| 180 | ALA | 183 | SER | 0.000 | 0.043 | -0.043 | 0.043 |
| 371 | LYS | 374 | GLN | 0.000 | 0.042 | -0.042 | 0.042 |
| 96 | ALA | 176 | TRP | 1.955 | 1.914 | 0.041 | 0.041 |
| 133 | LEU | 183 | SER | 4.997 | 4.957 | 0.041 | 0.041 |
| 139 | ILE | 143 | CYS | 0.000 | 0.041 | -0.041 | 0.041 |
| 131 | ASP | 395 | TRP | 0.000 | 0.040 | -0.040 | 0.040 |
| 404 | LEU | 409 | ARG | 0.443 | 0.483 | -0.040 | 0.040 |
| 154 | THR | 155 | GLN | 0.650 | 0.689 | -0.039 | 0.039 |
| 156 | ALA | 160 | ASN | 0.118 | 0.080 | 0.038 | 0.038 |
| 415 | PRO | 418 | LEU | 0.049 | 0.087 | -0.038 | 0.038 |
| 59 | GLY | 109 | LEU | 0.000 | 0.038 | -0.038 | 0.038 |
| 164 | THR | 166 | ARG | 0.475 | 0.439 | 0.036 | 0.036 |
| 78 | THR | 79 | SER | 0.000 | 0.034 | -0.034 | 0.034 |
| 73 | VAL | 77 | LEU | 0.788 | 0.755 | 0.033 | 0.033 |
| 70 | VAL | 74 | ILE | 0.911 | 0.878 | 0.033 | 0.033 |
| 69 | ASN | 434 | PRO | 5.624 | 5.656 | -0.032 | 0.032 |
| 387 | VAL | 429 | ASN | 0.000 | 0.032 | -0.032 | 0.032 |
| 121 | GLN | 190 | LEU | 0.000 | 0.031 | -0.031 | 0.031 |
| 210 | TYR | 402 | TYR | 0.000 | 0.031 | -0.031 | 0.031 |
| 418 | LEU | 421 | PHE | 0.357 | 0.388 | -0.031 | 0.031 |
| 210 | TYR | 215 | CYS | 0.032 | 0.002 | 0.029 | 0.029 |
| 386 | VAL | 390 | VAL | 0.191 | 0.162 | 0.029 | 0.029 |
| 402 | TYR | 405 | TYR | 0.055 | 0.084 | -0.029 | 0.029 |
| 279 | PRO | 280 | PRO | 0.649 | 0.621 | 0.029 | 0.029 |
| 411 | ALA | 412 | CYS | 0.028 | 0.000 | 0.028 | 0.028 |
| 449 | LYS | 453 | PHE | 1.083 | 1.111 | -0.028 | 0.028 |
| 362 | ARG | 365 | SER | 0.025 | 0.000 | 0.025 | 0.025 |
| 434 | PRO | 448 | PHE | 0.000 | 0.022 | -0.022 | 0.022 |
| 175 | VAL | 179 | SER | 0.193 | 0.171 | 0.022 | 0.022 |
| 172 | ILE | 176 | TRP | 0.974 | 0.953 | 0.021 | 0.021 |
| 92 | SER | 176 | TRP | 2.943 | 2.923 | 0.020 | 0.020 |
| 437 | TYR | 445 | ARG | 0.000 | 0.019 | -0.019 | 0.019 |
| 124 | CYS | 203 | GLY | 0.000 | 0.019 | -0.019 | 0.019 |
| 398 | PHE | 402 | TYR | 0.213 | 0.194 | 0.019 | 0.019 |
| 65 | THR | 101 | ALA | 1.169 | 1.152 | 0.017 | 0.017 |
| 194 | PRO | 199 | TYR | 0.017 | 0.000 | 0.017 | 0.017 |
| 73 | VAL | 94 | ALA | 0.539 | 0.522 | 0.016 | 0.016 |
| 396 | PHE | 400 | PHE | 2.493 | 2.509 | -0.016 | 0.016 |
| 89 | PHE | 172 | ILE | 2.673 | 2.657 | 0.016 | 0.016 |
| 105 | MET | 106 | PRO | 0.769 | 0.753 | 0.016 | 0.016 |
| 81 | ALA | 443 | ASP | 0.000 | 0.015 | -0.015 | 0.015 |
| 150 | TYR | 155 | GLN | 0.000 | 0.015 | -0.015 | 0.015 |
| 178 | ILE | 182 | ILE | 0.604 | 0.592 | 0.012 | 0.012 |
| 207 | GLU | 210 | TYR | 0.421 | 0.409 | 0.011 | 0.011 |
| 103 | LEU | 104 | VAL | 0.024 | 0.014 | 0.010 | 0.010 |
| 433 | ASN | 434 | PRO | 0.961 | 0.972 | -0.010 | 0.010 |
| 278 | PRO | 279 | PRO | 0.572 | 0.582 | -0.010 | 0.010 |
| 110 | ALA | 115 | ALA | 0.009 | 0.000 | 0.009 | 0.009 |
| 132 | VAL | 137 | SER | 0.019 | 0.012 | 0.008 | 0.008 |
| 140 | VAL | 222 | PRO | 0.007 | 0.000 | 0.007 | 0.007 |
| 167 | ARG | 171 | THR | 0.007 | 0.000 | 0.007 | 0.007 |
| 90 | LEU | 444 | PHE | 1.048 | 1.054 | -0.006 | 0.006 |
| 185 | PRO | 209 | TRP | 0.006 | 0.000 | 0.006 | 0.006 |
| 396 | PHE | 401 | SER | 0.006 | 0.000 | 0.006 | 0.006 |
| 153 | VAL | 236 | VAL | 0.400 | 0.395 | 0.005 | 0.005 |
| 73 | VAL | 95 | SER | 0.000 | 0.004 | -0.004 | 0.004 |
| 182 | ILE | 183 | SER | 0.004 | 0.000 | 0.004 | 0.004 |
| 46 | TYR | 420 | LYS | 0.045 | 0.042 | 0.004 | 0.004 |
| 422 | PHE | 425 | ILE | 0.282 | 0.284 | -0.002 | 0.002 |
| 139 | ILE | 222 | PRO | 1.270 | 1.268 | 0.002 | 0.002 |
| 318 | ALA | 319 | ASP | 1.785 | 1.784 | 0.001 | 0.001 |
RRCS change distribution
-0.16
Mean ΔRRCS
1.60
Std Dev
-0.08
Median
Magnitude classification
14
High (|Δ| ≥ 5.0)
66
Medium (2.2 ≤ |Δ| < 5.0)
643
Low (|Δ| < 2.2)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.24, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar