ADRB2
700
Total Contact Pairs
72
Significant Changes
8.84
Max Increase
-9.02
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | HIS390 | GLN391 | 0.000 | 9.019 | -9.019 | HIGH |
| 2 | CYS327 (7.54x54) | PHE332 (8.50x50) | 8.836 | 0.000 | +8.836 | HIGH |
| 3 | PHE89 (2.60x59) | TRP105 (3.24x24) | 0.000 | 7.537 | -7.537 | HIGH |
| 4 | ARG259 | GLU385 | 7.493 | 0.000 | +7.493 | HIGH |
| 5 | GLN337 (8.55x55) | ARG343 | 8.257 | 1.501 | +6.755 | HIGH |
| 6 | GLU338 (8.56x56) | ARG344 | 6.446 | 0.000 | +6.446 | HIGH |
| 7 | HIS241 | ARG260 | 5.805 | 0.000 | +5.805 | HIGH |
| 8 | PHE282 (6.44x44) | TRP286 (6.48x48) | 0.874 | 6.602 | -5.728 | HIGH |
| 9 | ASP130 (3.49x49) | ARG131 (3.50x50) | 0.376 | 6.046 | -5.670 | HIGH |
| 10 | ILE72 (2.43x43) | TYR326 (7.53x53) | 0.566 | 6.119 | -5.553 | HIGH |
| 11 | PHE208 (5.47x47) | PHE290 (6.52x52) | 12.764 | 18.106 | -5.342 | HIGH |
| 12 | GLU237 (5.76x76) | SER262 (6.24x24) | 0.000 | 5.326 | -5.326 | HIGH |
| 13 | PHE282 (6.44x44) | ASN318 (7.45x45) | 1.012 | 6.234 | -5.222 | HIGH |
| 14 | TYR219 (5.58x58) | GLY276 (6.38x38) | 0.000 | 5.093 | -5.093 | HIGH |
| 15 | ARG63 (12.49x49) | ILE334 (8.52x52) | 0.000 | 5.040 | -5.040 | HIGH |
| 16 | TYR219 (5.58x58) | LEU272 (6.34x34) | 0.000 | 4.853 | -4.853 | MED |
| 17 | ASP410 | SER411 | 0.000 | 4.583 | -4.583 | MED |
| 18 | TYR219 (5.58x58) | MET279 (6.41x41) | 1.398 | 5.745 | -4.347 | MED |
| 19 | ILE399 | ASP400 | 4.178 | 0.000 | +4.178 | MED |
| 20 | GLU122 (3.41x41) | SER161 (4.53x53) | 1.248 | 5.101 | -3.853 | MED |
| 21 | ALA128 (3.47x47) | TYR219 (5.58x58) | 4.878 | 1.110 | +3.768 | MED |
| 22 | ILE135 (3.54x54) | GLN229 (5.68x68) | 0.000 | 3.757 | -3.757 | MED |
| 23 | ARG175 | TYR185 | 6.462 | 10.205 | -3.743 | MED |
| 24 | LYS227 (5.66x66) | GLU268 (6.30x30) | 3.683 | 0.000 | +3.683 | MED |
| 25 | LEU230 (5.69x69) | PHE264 (6.26x26) | 3.496 | 0.000 | +3.496 | MED |
| 26 | LEU124 (3.43x43) | TYR326 (7.53x53) | 3.478 | 0.000 | +3.478 | MED |
| 27 | TRP99 (23.50x50) | CYS191 (45.50x50) | 4.131 | 7.567 | -3.437 | MED |
| 28 | LYS267 (6.29x29) | ASP331 (8.49x49) | 0.000 | 3.326 | -3.326 | MED |
| 29 | HIS93 (2.64x63) | CYS191 (45.50x50) | 3.174 | 0.092 | +3.082 | MED |
| 30 | GLN231 (5.70x70) | PHE264 (6.26x26) | 3.081 | 0.000 | +3.081 | MED |
| 31 | TRP99 (23.50x50) | TRP109 | 1.158 | 4.147 | -2.989 | MED |
| 32 | VAL114 | SER165 | 2.537 | 5.488 | -2.951 | MED |
| 33 | THR164 | TYR199 | 2.943 | 0.000 | +2.943 | MED |
| 34 | ILE121 | PHE282 (6.44x44) | 1.786 | 4.690 | -2.904 | MED |
| 35 | TYR326 (7.53x53) | PHE332 (8.50x50) | 0.000 | 2.867 | -2.867 | MED |
| 36 | ASP79 | SER120 | 3.204 | 0.349 | +2.855 | MED |
| 37 | ASN318 (7.45x45) | ASN322 | 3.160 | 0.436 | +2.724 | MED |
| 38 | ARG63 (12.49x49) | ASP331 (8.49x49) | 0.000 | 2.607 | -2.607 | MED |
| 39 | VAL292 | ILE303 | 3.642 | 1.041 | +2.601 | MED |
| 40 | ARG131 (3.50x50) | TYR141 | 0.000 | 2.594 | -2.594 | MED |
| 41 | LEU64 | PHE332 (8.50x50) | 4.002 | 1.410 | +2.592 | MED |
| 42 | ASN148 | ARG151 | 0.315 | 2.869 | -2.554 | MED |
| 43 | ILE121 | PHE208 (5.47x47) | 0.422 | 2.961 | -2.539 | MED |
| 44 | ILE121 | TRP286 (6.48x48) | 2.459 | 0.000 | +2.459 | MED |
| 45 | PHE10 | LEU12 | 2.448 | 0.000 | +2.448 | MED |
| 46 | TRP286 (6.48x48) | ASN318 (7.45x45) | 3.042 | 0.605 | +2.437 | MED |
| 47 | TRP105 (3.24x24) | PHE108 | 2.312 | 4.733 | -2.421 | MED |
| 48 | THR68 | ARG131 (3.50x50) | 2.882 | 5.287 | -2.405 | MED |
| 49 | GLY50 | PRO323 | 2.294 | 4.696 | -2.403 | MED |
| 50 | MET279 (6.41x41) | PHE282 (6.44x44) | 2.398 | 0.000 | +2.398 | MED |
| 51 | ILE121 | SER207 | 3.763 | 1.375 | +2.387 | MED |
| 52 | GLU338 (8.56x56) | ARG343 | 0.715 | 3.095 | -2.380 | MED |
| 53 | ILE325 | TYR326 (7.53x53) | 2.367 | 0.000 | +2.367 | MED |
| 54 | LEU53 | PHE336 | 4.567 | 6.905 | -2.338 | MED |
| 55 | PHE264 (6.26x26) | GLU268 (6.30x30) | 9.020 | 6.688 | +2.332 | MED |
| 56 | GLU225 | GLN229 (5.68x68) | 3.134 | 0.818 | +2.316 | MED |
| 57 | LEU381 | PRO382 | 2.311 | 0.000 | +2.311 | MED |
| 58 | HIS93 (2.64x63) | MET98 | 4.477 | 6.781 | -2.304 | MED |
| 59 | CYS125 | ILE214 | 2.264 | 0.000 | +2.264 | MED |
| 60 | TYR70 | ILE154 | 0.110 | 2.353 | -2.243 | MED |
| 61 | PHE289 | TYR308 | 5.007 | 7.221 | -2.214 | MED |
| 62 | LEU230 (5.69x69) | LYS267 (6.29x29) | 2.206 | 0.000 | +2.206 | MED |
| 63 | THR68 | ASP130 (3.49x49) | 5.175 | 3.014 | +2.161 | MED |
| 64 | ALA128 (3.47x47) | MET279 (6.41x41) | 0.000 | 2.125 | -2.125 | MED |
| 65 | PHE223 | LEU272 (6.34x34) | 2.124 | 0.000 | +2.124 | MED |
| 66 | GLN65 | LYS147 | 1.440 | 3.528 | -2.088 | MED |
| 67 | MET82 | VAL86 | 2.375 | 0.289 | +2.086 | MED |
| 68 | LEU144 | LYS149 | 1.778 | 3.844 | -2.066 | MED |
| 69 | GLN229 (5.68x68) | LYS232 | 2.063 | 0.000 | +2.063 | MED |
| 70 | THR274 | ILE325 | 0.000 | 2.056 | -2.056 | MED |
| 71 | MET215 | PHE282 (6.44x44) | 2.048 | 0.000 | +2.048 | MED |
| 72 | LEU230 (5.69x69) | GLU268 (6.30x30) | 1.983 | 0.000 | +1.983 | MED |
| 73 | GLN337 (8.55x55) | LEU342 | 5.053 | 3.102 | +1.951 | LOW |
| 74 | GLN197 | VAL297 | 2.984 | 4.928 | -1.944 | LOW |
| 75 | ASN103 | ASN187 | 4.365 | 2.427 | +1.938 | LOW |
| 76 | MET40 | TRP313 | 5.796 | 7.725 | -1.929 | LOW |
| 77 | PHE71 | ASP130 (3.49x49) | 3.713 | 1.791 | +1.922 | LOW |
| 78 | ARG63 (12.49x49) | ALA335 | 0.000 | 1.915 | -1.915 | LOW |
| 79 | TYR174 | TYR199 | 4.665 | 6.571 | -1.906 | LOW |
| 80 | VAL117 | TRP286 (6.48x48) | 3.438 | 5.336 | -1.898 | LOW |
| 81 | TYR132 | PHE133 | 1.851 | 0.000 | +1.851 | LOW |
| 82 | SER356 | ASN357 | 0.000 | 1.849 | -1.849 | LOW |
| 83 | ILE135 (3.54x54) | LEU272 (6.34x34) | 0.000 | 1.829 | -1.829 | LOW |
| 84 | PHE223 | LEU275 | 1.828 | 0.000 | +1.828 | LOW |
| 85 | TYR141 | LEU145 | 3.169 | 1.356 | +1.813 | LOW |
| 86 | PHE101 | TRP105 (3.24x24) | 1.175 | 2.984 | -1.809 | LOW |
| 87 | TYR219 (5.58x58) | ILE278 | 1.806 | 0.000 | +1.806 | LOW |
| 88 | VAL54 | TYR326 (7.53x53) | 0.000 | 1.804 | -1.804 | LOW |
| 89 | TYR70 | ARG151 | 5.145 | 3.341 | +1.804 | LOW |
| 90 | LEU124 (3.43x43) | ASN322 | 1.786 | 0.000 | +1.786 | LOW |
| 91 | ILE334 (8.52x52) | GLU338 (8.56x56) | 0.000 | 1.782 | -1.782 | LOW |
| 92 | ALA119 | TRP158 | 1.778 | 0.000 | +1.778 | LOW |
| 93 | THR281 | ASN318 (7.45x45) | 1.378 | 3.113 | -1.734 | LOW |
| 94 | LEU124 (3.43x43) | PHE282 (6.44x44) | 1.295 | 3.024 | -1.728 | LOW |
| 95 | ILE121 | LEU212 | 0.000 | 1.726 | -1.726 | LOW |
| 96 | CYS327 (7.54x54) | ARG333 | 0.000 | 1.722 | -1.722 | LOW |
| 97 | PHE289 | ASN312 | 7.946 | 6.226 | +1.720 | LOW |
| 98 | GLN26 | GLU30 | 1.103 | 2.820 | -1.717 | LOW |
| 99 | TYR219 (5.58x58) | LEU275 | 1.966 | 3.670 | -1.705 | LOW |
| 100 | SER204 | PHE290 (6.52x52) | 3.261 | 1.567 | +1.694 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 1.97 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | - | - | 0 | - | 0 |
| TM2 | 72-93 | 93 (3.1) | 1 | 89 (-7.5), 72 (-5.6) | 2 |
| TM3 | 105-135 | 128 (3.8), 124 (3.5) | 2 | 105 (-7.5), 130 (-5.7), 131 (-5.7), 122 (-3.9), 135 (-3.8) | 5 |
| TM4 | 161-161 | - | 0 | 161 (-3.9) | 1 |
| TM5 | 208-237 | 227 (3.7), 230 (3.5), 231 (3.1) | 3 | 208 (-5.3), 237 (-5.3), 219 (-5.1), 229 (-3.8) | 4 |
| TM6 | 262-290 | 268 (3.7), 264 (3.5) | 2 | 282 (-5.7), 286 (-5.7), 290 (-5.3), 262 (-5.3), 276 (-5.1), 272 (-4.9), 279 (-4.3), 267 (-3.3) | 8 |
| TM7 | 318-327 | 327 (8.8) | 1 | 326 (-5.6), 318 (-5.2) | 2 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 63-63 | - | 0 | 63 (-5.0) | 1 |
| ICL2 | - | - | 0 | - | 0 |
| ICL3 | 241-260 | 259 (7.5), 241 (5.8), 260 (5.8) | 3 | - | 0 |
| ECL1 | 99-99 | - | 0 | 99 (-3.4) | 1 |
| ECL2 | 175-191 | - | 0 | 175 (-3.7), 185 (-3.7), 191 (-3.4) | 3 |
| ECL3 | - | - | 0 | - | 0 |
| H8 | 331-338 | 332 (8.8), 337 (6.8), 338 (6.4) | 3 | 334 (-5.0), 331 (-3.3) | 2 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
53 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 391 | p.Gln391Pro | c.1172A>C | 6.92e-07 | 1 / 0 | 9.02 | 0.060 | BENIGN | 0.48 | |
| 390 | p.His390Arg | c.1169A>G | 1.38e-06 | 2 / 0 | 9.02 | 0.054 | BENIGN | 0.40 | rs1296785467 |
| 89 | p.Phe89Leu | c.265T>C | 6.84e-07 | 1 / 0 | 7.54 | 0.946 | PATHOGENIC | 0.52 | rs145233416 |
| 105 | p.Trp105Ser | c.314G>C | 6.84e-07 | 1 / 0 | 7.54 | 0.481 | AMBIGUOUS | 0.26 | |
| 89 | p.Phe89Val | c.265T>G | 6.84e-07 | 1 / 0 | 7.54 | - | nan | - | |
| 105 | p.Trp105Cys | c.315G>C | 6.84e-07 | 1 / 0 | 7.54 | - | nan | - | |
| 259 | p.Arg259Cys | c.775C>T | 4.10e-06 | 6 / 0 | 7.49 | 0.195 | BENIGN | 0.66 | rs765634337 |
| 259 | p.Arg259His | c.776G>A | 1.09e-05 | 16 / 0 | 7.49 | - | nan | - | rs201323763 |
| 343 | p.Arg343Ser | c.1027C>A | 1.37e-06 | 2 / 0 | 6.76 | 0.355 | AMBIGUOUS | 0.56 | rs1209605702 |
| 337 | p.Gln337Arg | c.1010A>G | 3.42e-06 | 5 / 0 | 6.76 | 0.090 | BENIGN | 0.50 | rs1329127387 |
| 343 | p.Arg343Cys | c.1027C>T | 2.05e-06 | 3 / 0 | 6.76 | - | nan | - | rs1209605702 |
| 343 | p.Arg343Leu | c.1028G>T | 1.37e-06 | 2 / 0 | 6.76 | - | nan | - | |
| 343 | p.Arg343His | c.1028G>A | 2.74e-06 | 4 / 0 | 6.76 | - | nan | - | rs748580918 |
| 338 | p.Glu338Asp | c.1014G>C | 3.42e-06 | 5 / 0 | 6.45 | 0.259 | BENIGN | 0.45 | |
| 344 | p.Arg344Lys | c.1031G>A | 6.57e-06 | 1 / 0 | 6.45 | 0.074 | BENIGN | 0.66 | rs2127360047 |
| 260 | p.Arg260Thr | c.779G>C | 2.05e-06 | 3 / 0 | 5.80 | 0.440 | AMBIGUOUS | 0.50 | rs1362685333 |
| 260 | p.Arg260Ser | c.780A>T | 6.84e-07 | 1 / 0 | 5.80 | - | nan | - | |
| 260 | p.Arg260Ser | c.780A>C | 1.37e-06 | 2 / 0 | 5.80 | - | nan | - | |
| 130 | p.Asp130Asn | c.388G>A | 6.84e-07 | 1 / 0 | 5.67 | 0.990 | PATHOGENIC | 0.99 | |
| 131 | p.Arg131Cys | c.391C>T | 2.05e-06 | 3 / 0 | 5.67 | 0.979 | PATHOGENIC | 1.00 | |
| 131 | p.Arg131Leu | c.392G>T | 6.84e-07 | 1 / 0 | 5.67 | - | nan | - | |
| 131 | p.Arg131His | c.392G>A | 1.37e-06 | 2 / 0 | 5.67 | - | nan | - | |
| 326 | p.Tyr326Cys | c.977A>G | 6.84e-07 | 1 / 0 | 5.55 | 0.983 | PATHOGENIC | 0.98 | |
| 72 | p.Ile72Val | c.214A>G | 1.37e-06 | 2 / 0 | 5.55 | 0.241 | BENIGN | 0.82 | |
| 208 | p.Phe208Leu | c.622T>C | 3.42e-06 | 5 / 0 | 5.34 | 0.999 | PATHOGENIC | 0.98 | |
| 290 | p.Phe290Val | c.868T>G | 6.57e-06 | 1 / 0 | 5.34 | 0.994 | PATHOGENIC | 0.98 | rs749002771 |
| 237 | p.Glu237Lys | c.709G>A | 2.74e-06 | 4 / 0 | 5.33 | 0.230 | BENIGN | 0.60 | rs1204656662 |
| 262 | p.Ser262Cys | c.785C>G | 6.84e-07 | 1 / 0 | 5.33 | 0.177 | BENIGN | 0.44 | |
| 276 | p.Gly276Ser | c.826G>A | 6.84e-07 | 1 / 0 | 5.09 | 0.855 | PATHOGENIC | 0.81 | rs751770115 |
| 276 | p.Gly276Asp | c.827G>A | 6.84e-07 | 1 / 0 | 5.09 | - | nan | - | |
| 63 | p.Arg63Gly | c.187C>G | 5.47e-06 | 8 / 0 | 5.04 | 0.755 | PATHOGENIC | 0.71 | |
| 334 | p.Ile334Asn | c.1001T>A | 2.19e-05 | 32 / 0 | 5.04 | 0.140 | BENIGN | 0.35 | rs746492442 |
| 63 | p.Arg63His | c.188G>A | 1.37e-06 | 2 / 0 | 5.04 | - | nan | - | rs1156310662 |
| 334 | p.Ile334Met | c.1002T>G | 6.57e-06 | 1 / 0 | 5.04 | - | nan | - | rs1411817844 |
| 410 | p.Asp410Ala | c.1229A>C | 1.40e-06 | 2 / 0 | 4.58 | 0.111 | BENIGN | 0.75 | rs746434318 |
| 400 | p.Asp400Ala | c.1199A>C | 5.58e-06 | 8 / 0 | 4.18 | 0.096 | BENIGN | 0.68 | rs1186444145 |
| 161 | p.Ser161Leu | c.482C>T | 6.84e-07 | 1 / 0 | 3.85 | 0.956 | PATHOGENIC | 0.82 | |
| 122 | p.Glu122Asp | c.366G>C | 6.84e-07 | 1 / 0 | 3.85 | 0.884 | PATHOGENIC | 0.59 | |
| 128 | p.Ala128Thr | c.382G>A | 2.05e-06 | 3 / 0 | 3.77 | 0.942 | PATHOGENIC | 0.76 | rs149199162 |
| 128 | p.Ala128Ser | c.382G>T | 5.34e-05 | 78 / 0 | 3.77 | - | nan | - | rs149199162 |
| 128 | p.Ala128Val | c.383C>T | 6.84e-07 | 1 / 0 | 3.77 | - | nan | - | |
| 135 | p.Ile135Val | c.403A>G | 6.84e-07 | 1 / 0 | 3.76 | 0.241 | BENIGN | 0.89 | |
| 175 | p.Arg175Gly | c.523C>G | 6.84e-07 | 1 / 0 | 3.74 | 0.716 | PATHOGENIC | 0.70 | |
| 185 | p.Tyr185Cys | c.554A>G | 6.84e-07 | 1 / 0 | 3.74 | 0.622 | PATHOGENIC | 0.55 | |
| 175 | p.Arg175Trp | c.523C>T | 6.84e-07 | 1 / 0 | 3.74 | - | nan | - | rs1042718 |
| 227 | p.Lys227Gln | c.679A>C | 6.84e-07 | 1 / 0 | 3.68 | 0.115 | BENIGN | 0.51 | |
| 227 | p.Lys227Glu | c.679A>G | 2.74e-06 | 4 / 0 | 3.68 | - | nan | - | rs972763826 |
| 227 | p.Lys227Arg | c.680A>G | 2.05e-06 | 3 / 0 | 3.68 | - | nan | - | |
| 264 | p.Phe264Ser | c.791T>C | 6.84e-07 | 1 / 0 | 3.50 | 0.757 | PATHOGENIC | 0.55 | rs1304524860 |
| 264 | p.Phe264Leu | c.792C>A | 2.05e-06 | 3 / 0 | 3.50 | - | nan | - | |
| 267 | p.Lys267Glu | c.799A>G | 2.05e-06 | 3 / 0 | 3.33 | 0.847 | PATHOGENIC | 0.79 | |
| 267 | p.Lys267Asn | c.801G>C | 2.60e-05 | 38 / 0 | 3.33 | - | nan | - | rs1041227804 |
| 231 | p.Gln231Arg | c.692A>G | 6.84e-07 | 1 / 0 | 3.08 | 0.066 | BENIGN | 0.64 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 1.97, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 390 | HIS | 391 | GLN | 0.000 | 9.019 | -9.019 | 9.019 |
| 327 | CYS | 332 | PHE | 8.836 | 0.000 | 8.836 | 8.836 |
| 89 | PHE | 105 | TRP | 0.000 | 7.537 | -7.537 | 7.537 |
| 259 | ARG | 385 | GLU | 7.493 | 0.000 | 7.493 | 7.493 |
| 337 | GLN | 343 | ARG | 8.257 | 1.501 | 6.755 | 6.755 |
| 338 | GLU | 344 | ARG | 6.446 | 0.000 | 6.446 | 6.446 |
| 241 | HIS | 260 | ARG | 5.805 | 0.000 | 5.805 | 5.805 |
| 282 | PHE | 286 | TRP | 0.874 | 6.602 | -5.728 | 5.728 |
| 130 | ASP | 131 | ARG | 0.376 | 6.046 | -5.670 | 5.670 |
| 72 | ILE | 326 | TYR | 0.566 | 6.119 | -5.553 | 5.553 |
| 208 | PHE | 290 | PHE | 12.764 | 18.106 | -5.342 | 5.342 |
| 237 | GLU | 262 | SER | 0.000 | 5.326 | -5.326 | 5.326 |
| 282 | PHE | 318 | ASN | 1.012 | 6.234 | -5.222 | 5.222 |
| 219 | TYR | 276 | GLY | 0.000 | 5.093 | -5.093 | 5.093 |
| 63 | ARG | 334 | ILE | 0.000 | 5.040 | -5.040 | 5.040 |
| 219 | TYR | 272 | LEU | 0.000 | 4.853 | -4.853 | 4.853 |
| 410 | ASP | 411 | SER | 0.000 | 4.583 | -4.583 | 4.583 |
| 219 | TYR | 279 | MET | 1.398 | 5.745 | -4.347 | 4.347 |
| 399 | ILE | 400 | ASP | 4.178 | 0.000 | 4.178 | 4.178 |
| 122 | GLU | 161 | SER | 1.248 | 5.101 | -3.853 | 3.853 |
| 128 | ALA | 219 | TYR | 4.878 | 1.110 | 3.768 | 3.768 |
| 135 | ILE | 229 | GLN | 0.000 | 3.757 | -3.757 | 3.757 |
| 175 | ARG | 185 | TYR | 6.462 | 10.205 | -3.743 | 3.743 |
| 227 | LYS | 268 | GLU | 3.683 | 0.000 | 3.683 | 3.683 |
| 230 | LEU | 264 | PHE | 3.496 | 0.000 | 3.496 | 3.496 |
| 124 | LEU | 326 | TYR | 3.478 | 0.000 | 3.478 | 3.478 |
| 99 | TRP | 191 | CYS | 4.131 | 7.567 | -3.437 | 3.437 |
| 267 | LYS | 331 | ASP | 0.000 | 3.326 | -3.326 | 3.326 |
| 93 | HIS | 191 | CYS | 3.174 | 0.092 | 3.082 | 3.082 |
| 231 | GLN | 264 | PHE | 3.081 | 0.000 | 3.081 | 3.081 |
| 99 | TRP | 109 | TRP | 1.158 | 4.147 | -2.989 | 2.989 |
| 114 | VAL | 165 | SER | 2.537 | 5.488 | -2.951 | 2.951 |
| 164 | THR | 199 | TYR | 2.943 | 0.000 | 2.943 | 2.943 |
| 121 | ILE | 282 | PHE | 1.786 | 4.690 | -2.904 | 2.904 |
| 326 | TYR | 332 | PHE | 0.000 | 2.867 | -2.867 | 2.867 |
| 79 | ASP | 120 | SER | 3.204 | 0.349 | 2.855 | 2.855 |
| 318 | ASN | 322 | ASN | 3.160 | 0.436 | 2.724 | 2.724 |
| 63 | ARG | 331 | ASP | 0.000 | 2.607 | -2.607 | 2.607 |
| 292 | VAL | 303 | ILE | 3.642 | 1.041 | 2.601 | 2.601 |
| 131 | ARG | 141 | TYR | 0.000 | 2.594 | -2.594 | 2.594 |
| 64 | LEU | 332 | PHE | 4.002 | 1.410 | 2.592 | 2.592 |
| 148 | ASN | 151 | ARG | 0.315 | 2.869 | -2.554 | 2.554 |
| 121 | ILE | 208 | PHE | 0.422 | 2.961 | -2.539 | 2.539 |
| 121 | ILE | 286 | TRP | 2.459 | 0.000 | 2.459 | 2.459 |
| 10 | PHE | 12 | LEU | 2.448 | 0.000 | 2.448 | 2.448 |
| 286 | TRP | 318 | ASN | 3.042 | 0.605 | 2.437 | 2.437 |
| 105 | TRP | 108 | PHE | 2.312 | 4.733 | -2.421 | 2.421 |
| 68 | THR | 131 | ARG | 2.882 | 5.287 | -2.405 | 2.405 |
| 50 | GLY | 323 | PRO | 2.294 | 4.696 | -2.403 | 2.403 |
| 279 | MET | 282 | PHE | 2.398 | 0.000 | 2.398 | 2.398 |
| 121 | ILE | 207 | SER | 3.763 | 1.375 | 2.387 | 2.387 |
| 338 | GLU | 343 | ARG | 0.715 | 3.095 | -2.380 | 2.380 |
| 325 | ILE | 326 | TYR | 2.367 | 0.000 | 2.367 | 2.367 |
| 53 | LEU | 336 | PHE | 4.567 | 6.905 | -2.338 | 2.338 |
| 264 | PHE | 268 | GLU | 9.020 | 6.688 | 2.332 | 2.332 |
| 225 | GLU | 229 | GLN | 3.134 | 0.818 | 2.316 | 2.316 |
| 381 | LEU | 382 | PRO | 2.311 | 0.000 | 2.311 | 2.311 |
| 93 | HIS | 98 | MET | 4.477 | 6.781 | -2.304 | 2.304 |
| 125 | CYS | 214 | ILE | 2.264 | 0.000 | 2.264 | 2.264 |
| 70 | TYR | 154 | ILE | 0.110 | 2.353 | -2.243 | 2.243 |
| 289 | PHE | 308 | TYR | 5.007 | 7.221 | -2.214 | 2.214 |
| 230 | LEU | 267 | LYS | 2.206 | 0.000 | 2.206 | 2.206 |
| 68 | THR | 130 | ASP | 5.175 | 3.014 | 2.161 | 2.161 |
| 128 | ALA | 279 | MET | 0.000 | 2.125 | -2.125 | 2.125 |
| 223 | PHE | 272 | LEU | 2.124 | 0.000 | 2.124 | 2.124 |
| 65 | GLN | 147 | LYS | 1.440 | 3.528 | -2.088 | 2.088 |
| 82 | MET | 86 | VAL | 2.375 | 0.289 | 2.086 | 2.086 |
| 144 | LEU | 149 | LYS | 1.778 | 3.844 | -2.066 | 2.066 |
| 229 | GLN | 232 | LYS | 2.063 | 0.000 | 2.063 | 2.063 |
| 274 | THR | 325 | ILE | 0.000 | 2.056 | -2.056 | 2.056 |
| 215 | MET | 282 | PHE | 2.048 | 0.000 | 2.048 | 2.048 |
| 230 | LEU | 268 | GLU | 1.983 | 0.000 | 1.983 | 1.983 |
| 337 | GLN | 342 | LEU | 5.053 | 3.102 | 1.951 | 1.951 |
| 197 | GLN | 297 | VAL | 2.984 | 4.928 | -1.944 | 1.944 |
| 103 | ASN | 187 | ASN | 4.365 | 2.427 | 1.938 | 1.938 |
| 40 | MET | 313 | TRP | 5.796 | 7.725 | -1.929 | 1.929 |
| 71 | PHE | 130 | ASP | 3.713 | 1.791 | 1.922 | 1.922 |
| 63 | ARG | 335 | ALA | 0.000 | 1.915 | -1.915 | 1.915 |
| 174 | TYR | 199 | TYR | 4.665 | 6.571 | -1.906 | 1.906 |
| 117 | VAL | 286 | TRP | 3.438 | 5.336 | -1.898 | 1.898 |
| 132 | TYR | 133 | PHE | 1.851 | 0.000 | 1.851 | 1.851 |
| 356 | SER | 357 | ASN | 0.000 | 1.849 | -1.849 | 1.849 |
| 135 | ILE | 272 | LEU | 0.000 | 1.829 | -1.829 | 1.829 |
| 223 | PHE | 275 | LEU | 1.828 | 0.000 | 1.828 | 1.828 |
| 141 | TYR | 145 | LEU | 3.169 | 1.356 | 1.813 | 1.813 |
| 101 | PHE | 105 | TRP | 1.175 | 2.984 | -1.809 | 1.809 |
| 219 | TYR | 278 | ILE | 1.806 | 0.000 | 1.806 | 1.806 |
| 54 | VAL | 326 | TYR | 0.000 | 1.804 | -1.804 | 1.804 |
| 70 | TYR | 151 | ARG | 5.145 | 3.341 | 1.804 | 1.804 |
| 124 | LEU | 322 | ASN | 1.786 | 0.000 | 1.786 | 1.786 |
| 334 | ILE | 338 | GLU | 0.000 | 1.782 | -1.782 | 1.782 |
| 119 | ALA | 158 | TRP | 1.778 | 0.000 | 1.778 | 1.778 |
| 281 | THR | 318 | ASN | 1.378 | 3.113 | -1.734 | 1.734 |
| 124 | LEU | 282 | PHE | 1.295 | 3.024 | -1.728 | 1.728 |
| 121 | ILE | 212 | LEU | 0.000 | 1.726 | -1.726 | 1.726 |
| 327 | CYS | 333 | ARG | 0.000 | 1.722 | -1.722 | 1.722 |
| 289 | PHE | 312 | ASN | 7.946 | 6.226 | 1.720 | 1.720 |
| 26 | GLN | 30 | GLU | 1.103 | 2.820 | -1.717 | 1.717 |
| 219 | TYR | 275 | LEU | 1.966 | 3.670 | -1.705 | 1.705 |
| 204 | SER | 290 | PHE | 3.261 | 1.567 | 1.694 | 1.694 |
| 131 | ARG | 275 | LEU | 0.000 | 1.668 | -1.668 | 1.668 |
| 208 | PHE | 287 | LEU | 4.924 | 3.272 | 1.653 | 1.653 |
| 131 | ARG | 134 | ALA | 0.000 | 1.642 | -1.642 | 1.642 |
| 75 | LEU | 123 | THR | 2.910 | 1.281 | 1.629 | 1.629 |
| 54 | VAL | 327 | CYS | 1.628 | 0.000 | 1.628 | 1.628 |
| 47 | ILE | 319 | SER | 1.321 | 2.905 | -1.584 | 1.584 |
| 277 | ILE | 328 | ARG | 0.559 | 2.138 | -1.579 | 1.579 |
| 146 | THR | 149 | LYS | 0.678 | 2.246 | -1.568 | 1.568 |
| 74 | SER | 154 | ILE | 3.680 | 2.129 | 1.550 | 1.550 |
| 385 | GLU | 386 | ASP | 0.000 | 1.548 | -1.548 | 1.548 |
| 75 | LEU | 124 | LEU | 2.159 | 0.622 | 1.537 | 1.537 |
| 212 | LEU | 283 | THR | 0.250 | 1.782 | -1.532 | 1.532 |
| 174 | TYR | 193 | PHE | 0.109 | 1.637 | -1.528 | 1.528 |
| 233 | ILE | 265 | CYS | 0.000 | 1.506 | -1.506 | 1.506 |
| 277 | ILE | 325 | ILE | 0.426 | 1.891 | -1.465 | 1.465 |
| 99 | TRP | 105 | TRP | 2.018 | 3.478 | -1.460 | 1.460 |
| 131 | ARG | 222 | VAL | 0.000 | 1.448 | -1.448 | 1.448 |
| 134 | ALA | 141 | TYR | 6.086 | 7.493 | -1.407 | 1.407 |
| 165 | SER | 166 | PHE | 1.585 | 0.183 | 1.402 | 1.402 |
| 20 | PRO | 22 | HIS | 1.399 | 0.000 | 1.399 | 1.399 |
| 29 | ASP | 97 | LYS | 0.000 | 1.398 | -1.398 | 1.398 |
| 124 | LEU | 279 | MET | 0.000 | 1.375 | -1.375 | 1.375 |
| 215 | MET | 279 | MET | 2.295 | 3.661 | -1.367 | 1.367 |
| 234 | ASP | 264 | PHE | 1.366 | 0.000 | 1.366 | 1.366 |
| 99 | TRP | 189 | THR | 8.084 | 9.449 | -1.365 | 1.365 |
| 274 | THR | 328 | ARG | 0.000 | 1.356 | -1.356 | 1.356 |
| 278 | ILE | 326 | TYR | 1.451 | 2.805 | -1.354 | 1.354 |
| 213 | VAL | 217 | PHE | 1.344 | 0.000 | 1.344 | 1.344 |
| 89 | PHE | 109 | TRP | 3.337 | 1.997 | 1.339 | 1.339 |
| 13 | ALA | 14 | PRO | 0.509 | 1.839 | -1.330 | 1.330 |
| 278 | ILE | 322 | ASN | 0.000 | 1.322 | -1.322 | 1.322 |
| 130 | ASP | 141 | TYR | 7.932 | 6.613 | 1.319 | 1.319 |
| 135 | ILE | 222 | VAL | 0.894 | 2.212 | -1.318 | 1.318 |
| 132 | TYR | 136 | THR | 5.136 | 3.829 | 1.307 | 1.307 |
| 127 | ILE | 279 | MET | 0.000 | 1.301 | -1.301 | 1.301 |
| 168 | PRO | 199 | TYR | 3.165 | 1.865 | 1.300 | 1.300 |
| 199 | TYR | 203 | SER | 1.966 | 3.265 | -1.298 | 1.298 |
| 77 | CYS | 158 | TRP | 0.130 | 1.424 | -1.293 | 1.293 |
| 67 | VAL | 141 | TYR | 0.000 | 1.288 | -1.288 | 1.288 |
| 132 | TYR | 222 | VAL | 1.497 | 2.761 | -1.265 | 1.265 |
| 286 | TRP | 312 | ASN | 0.199 | 1.460 | -1.261 | 1.261 |
| 125 | CYS | 211 | PRO | 2.159 | 3.407 | -1.249 | 1.249 |
| 118 | THR | 207 | SER | 5.258 | 4.023 | 1.235 | 1.235 |
| 89 | PHE | 101 | PHE | 3.553 | 4.767 | -1.214 | 1.214 |
| 240 | PHE | 243 | GLN | 0.000 | 1.213 | -1.213 | 1.213 |
| 131 | ARG | 272 | LEU | 0.000 | 1.201 | -1.201 | 1.201 |
| 221 | ARG | 224 | GLN | 2.659 | 1.462 | 1.197 | 1.197 |
| 359 | ASN | 360 | THR | 0.236 | 1.424 | -1.187 | 1.187 |
| 238 | GLY | 260 | ARG | 1.175 | 0.000 | 1.175 | 1.175 |
| 285 | CYS | 318 | ASN | 3.230 | 2.060 | 1.170 | 1.170 |
| 115 | LEU | 161 | SER | 3.687 | 2.521 | 1.166 | 1.166 |
| 79 | ASP | 322 | ASN | 4.388 | 3.222 | 1.166 | 1.166 |
| 69 | ASN | 332 | PHE | 2.889 | 1.724 | 1.166 | 1.166 |
| 65 | GLN | 70 | TYR | 0.000 | 1.163 | -1.163 | 1.163 |
| 215 | MET | 219 | TYR | 1.139 | 0.000 | 1.139 | 1.139 |
| 296 | HIS | 303 | ILE | 1.605 | 0.469 | 1.136 | 1.136 |
| 241 | HIS | 245 | LEU | 0.301 | 1.414 | -1.114 | 1.114 |
| 279 | MET | 283 | THR | 1.111 | 0.000 | 1.111 | 1.111 |
| 286 | TRP | 316 | TYR | 0.897 | 1.997 | -1.100 | 1.100 |
| 120 | SER | 282 | PHE | 0.000 | 1.086 | -1.086 | 1.086 |
| 219 | TYR | 222 | VAL | 0.000 | 1.077 | -1.077 | 1.077 |
| 185 | TYR | 194 | PHE | 4.492 | 5.565 | -1.073 | 1.073 |
| 283 | THR | 287 | LEU | 1.502 | 0.439 | 1.063 | 1.063 |
| 107 | GLU | 174 | TYR | 1.430 | 2.485 | -1.056 | 1.056 |
| 384 | THR | 385 | GLU | 0.000 | 1.046 | -1.046 | 1.046 |
| 79 | ASP | 319 | SER | 12.100 | 11.061 | 1.039 | 1.039 |
| 164 | THR | 206 | VAL | 1.271 | 0.232 | 1.039 | 1.039 |
| 125 | CYS | 215 | MET | 2.612 | 1.574 | 1.038 | 1.038 |
| 178 | HIS | 194 | PHE | 3.571 | 2.541 | 1.029 | 1.029 |
| 115 | LEU | 165 | SER | 5.365 | 4.341 | 1.023 | 1.023 |
| 122 | GLU | 206 | VAL | 1.021 | 0.000 | 1.021 | 1.021 |
| 225 | GLU | 228 | ARG | 2.769 | 3.786 | -1.017 | 1.017 |
| 99 | TRP | 101 | PHE | 5.387 | 6.400 | -1.013 | 1.013 |
| 208 | PHE | 282 | PHE | 1.732 | 0.723 | 1.009 | 1.009 |
| 68 | THR | 141 | TYR | 1.311 | 0.308 | 1.004 | 1.004 |
| 93 | HIS | 99 | TRP | 2.657 | 3.653 | -0.996 | 0.996 |
| 114 | VAL | 199 | TYR | 0.991 | 0.000 | 0.991 | 0.991 |
| 163 | LEU | 168 | PRO | 2.269 | 1.284 | 0.985 | 0.985 |
| 127 | ILE | 326 | TYR | 0.964 | 0.000 | 0.964 | 0.964 |
| 111 | SER | 166 | PHE | 6.481 | 7.444 | -0.962 | 0.962 |
| 61 | PHE | 338 | GLU | 4.544 | 3.593 | 0.951 | 0.951 |
| 167 | LEU | 173 | TRP | 1.966 | 2.901 | -0.935 | 0.935 |
| 208 | PHE | 286 | TRP | 3.264 | 2.330 | 0.933 | 0.933 |
| 32 | TRP | 36 | MET | 5.471 | 4.539 | 0.932 | 0.932 |
| 122 | GLU | 160 | VAL | 3.125 | 2.194 | 0.930 | 0.930 |
| 266 | LEU | 270 | LYS | 0.000 | 0.924 | -0.924 | 0.924 |
| 71 | PHE | 150 | ALA | 2.975 | 2.056 | 0.919 | 0.919 |
| 217 | PHE | 221 | ARG | 0.000 | 0.904 | -0.904 | 0.904 |
| 169 | ILE | 199 | TYR | 1.868 | 0.968 | 0.900 | 0.900 |
| 393 | THR | 394 | VAL | 0.450 | 1.349 | -0.899 | 0.899 |
| 75 | LEU | 79 | ASP | 1.823 | 0.927 | 0.896 | 0.896 |
| 395 | PRO | 396 | SER | 0.211 | 1.106 | -0.895 | 0.895 |
| 82 | MET | 319 | SER | 0.950 | 1.842 | -0.892 | 0.892 |
| 259 | ARG | 263 | LYS | 0.000 | 0.889 | -0.889 | 0.889 |
| 127 | ILE | 275 | LEU | 0.000 | 0.882 | -0.882 | 0.882 |
| 111 | SER | 165 | SER | 1.876 | 0.996 | 0.881 | 0.881 |
| 212 | LEU | 282 | PHE | 0.876 | 0.000 | 0.876 | 0.876 |
| 99 | TRP | 106 | CYS | 5.277 | 6.141 | -0.864 | 0.864 |
| 58 | ILE | 69 | ASN | 1.182 | 2.044 | -0.862 | 0.862 |
| 135 | ILE | 225 | GLU | 0.403 | 1.258 | -0.855 | 0.855 |
| 278 | ILE | 325 | ILE | 1.276 | 2.123 | -0.847 | 0.847 |
| 118 | THR | 165 | SER | 0.000 | 0.828 | -0.828 | 0.828 |
| 71 | PHE | 126 | VAL | 2.686 | 3.506 | -0.820 | 0.820 |
| 215 | MET | 283 | THR | 0.000 | 0.818 | -0.818 | 0.818 |
| 75 | LEU | 322 | ASN | 2.612 | 1.807 | 0.805 | 0.805 |
| 271 | ALA | 413 | LEU | 0.801 | 0.000 | 0.801 | 0.801 |
| 162 | GLY | 167 | LEU | 1.270 | 0.473 | 0.796 | 0.796 |
| 329 | SER | 332 | PHE | 2.601 | 1.812 | 0.789 | 0.789 |
| 86 | VAL | 113 | ASP | 4.779 | 4.011 | 0.768 | 0.768 |
| 327 | CYS | 336 | PHE | 2.110 | 1.345 | 0.765 | 0.765 |
| 59 | ALA | 65 | GLN | 0.967 | 1.730 | -0.764 | 0.764 |
| 36 | MET | 40 | MET | 0.000 | 0.758 | -0.758 | 0.758 |
| 332 | PHE | 336 | PHE | 2.674 | 1.928 | 0.745 | 0.745 |
| 237 | GLU | 258 | LEU | 0.000 | 0.743 | -0.743 | 0.743 |
| 117 | VAL | 121 | ILE | 0.736 | 0.000 | 0.736 | 0.736 |
| 179 | GLN | 183 | ASN | 3.441 | 4.173 | -0.732 | 0.732 |
| 192 | ASP | 305 | LYS | 5.812 | 5.081 | 0.730 | 0.730 |
| 61 | PHE | 335 | ALA | 6.791 | 6.062 | 0.729 | 0.729 |
| 129 | VAL | 218 | VAL | 0.844 | 1.572 | -0.728 | 0.728 |
| 362 | GLU | 363 | GLN | 0.943 | 0.218 | 0.725 | 0.725 |
| 273 | LYS | 328 | ARG | 0.000 | 0.724 | -0.724 | 0.724 |
| 121 | ILE | 290 | PHE | 0.723 | 0.000 | 0.723 | 0.723 |
| 107 | GLU | 169 | ILE | 1.246 | 1.968 | -0.722 | 0.722 |
| 71 | PHE | 127 | ILE | 1.582 | 2.299 | -0.717 | 0.717 |
| 208 | PHE | 212 | LEU | 1.997 | 1.281 | 0.716 | 0.716 |
| 286 | TRP | 289 | PHE | 0.325 | 1.034 | -0.709 | 0.709 |
| 70 | TYR | 147 | LYS | 0.000 | 0.709 | -0.709 | 0.709 |
| 120 | SER | 322 | ASN | 0.706 | 0.000 | 0.706 | 0.706 |
| 192 | ASP | 194 | PHE | 1.988 | 2.692 | -0.704 | 0.704 |
| 145 | LEU | 150 | ALA | 0.024 | 0.728 | -0.704 | 0.704 |
| 222 | VAL | 272 | LEU | 0.000 | 0.696 | -0.696 | 0.696 |
| 398 | ASN | 399 | ILE | 0.914 | 0.220 | 0.694 | 0.694 |
| 84 | LEU | 89 | PHE | 0.000 | 0.694 | -0.694 | 0.694 |
| 177 | THR | 182 | ILE | 1.446 | 2.138 | -0.691 | 0.691 |
| 233 | ILE | 237 | GLU | 1.184 | 0.494 | 0.691 | 0.691 |
| 92 | ALA | 101 | PHE | 0.000 | 0.686 | -0.686 | 0.686 |
| 67 | VAL | 130 | ASP | 0.000 | 0.686 | -0.686 | 0.686 |
| 110 | THR | 193 | PHE | 1.624 | 2.308 | -0.684 | 0.684 |
| 82 | MET | 316 | TYR | 2.657 | 1.977 | 0.680 | 0.680 |
| 124 | LEU | 278 | ILE | 0.000 | 0.680 | -0.680 | 0.680 |
| 135 | ILE | 226 | ALA | 0.000 | 0.679 | -0.679 | 0.679 |
| 226 | ALA | 272 | LEU | 0.000 | 0.677 | -0.677 | 0.677 |
| 176 | ALA | 194 | PHE | 1.543 | 0.866 | 0.677 | 0.677 |
| 289 | PHE | 290 | PHE | 1.524 | 0.847 | 0.676 | 0.676 |
| 285 | CYS | 314 | ILE | 4.531 | 5.207 | -0.676 | 0.676 |
| 281 | THR | 325 | ILE | 1.732 | 1.060 | 0.672 | 0.672 |
| 401 | SER | 402 | GLN | 0.000 | 0.663 | -0.663 | 0.663 |
| 334 | ILE | 343 | ARG | 1.962 | 1.300 | 0.662 | 0.662 |
| 115 | LEU | 166 | PHE | 1.966 | 1.310 | 0.656 | 0.656 |
| 75 | LEU | 127 | ILE | 0.654 | 0.000 | 0.654 | 0.654 |
| 129 | VAL | 214 | ILE | 0.652 | 0.000 | 0.652 | 0.652 |
| 196 | ASN | 199 | TYR | 1.189 | 1.834 | -0.645 | 0.645 |
| 128 | ALA | 222 | VAL | 0.000 | 0.645 | -0.645 | 0.645 |
| 340 | LEU | 342 | LEU | 0.475 | 1.116 | -0.641 | 0.641 |
| 212 | LEU | 215 | MET | 0.000 | 0.638 | -0.638 | 0.638 |
| 240 | PHE | 258 | LEU | 0.000 | 0.633 | -0.633 | 0.633 |
| 118 | THR | 164 | THR | 1.164 | 0.534 | 0.629 | 0.629 |
| 299 | GLN | 302 | LEU | 1.462 | 2.087 | -0.624 | 0.624 |
| 209 | TYR | 291 | ILE | 1.715 | 2.336 | -0.622 | 0.622 |
| 98 | MET | 100 | THR | 0.035 | 0.657 | -0.622 | 0.622 |
| 219 | TYR | 326 | TYR | 0.613 | 0.000 | 0.613 | 0.613 |
| 103 | ASN | 188 | GLU | 6.028 | 5.417 | 0.611 | 0.611 |
| 117 | VAL | 290 | PHE | 0.261 | 0.871 | -0.610 | 0.610 |
| 58 | ILE | 64 | LEU | 1.393 | 2.001 | -0.609 | 0.609 |
| 72 | ILE | 127 | ILE | 0.941 | 0.332 | 0.608 | 0.608 |
| 328 | ARG | 333 | ARG | 0.597 | 0.000 | 0.597 | 0.597 |
| 98 | MET | 189 | THR | 2.354 | 2.947 | -0.593 | 0.593 |
| 201 | ILE | 297 | VAL | 0.032 | 0.621 | -0.589 | 0.589 |
| 3 | GLN | 4 | PRO | 0.979 | 0.390 | 0.589 | 0.589 |
| 135 | ILE | 412 | LEU | 0.588 | 0.000 | 0.588 | 0.588 |
| 160 | VAL | 206 | VAL | 0.588 | 0.000 | 0.588 | 0.588 |
| 19 | ALA | 20 | PRO | 0.587 | 0.000 | 0.587 | 0.587 |
| 184 | CYS | 190 | CYS | 8.554 | 9.133 | -0.578 | 0.578 |
| 136 | THR | 137 | SER | 0.535 | 1.111 | -0.576 | 0.576 |
| 48 | VAL | 83 | GLY | 2.160 | 1.586 | 0.574 | 0.574 |
| 87 | VAL | 313 | TRP | 2.461 | 1.888 | 0.573 | 0.573 |
| 333 | ARG | 337 | GLN | 0.000 | 0.569 | -0.569 | 0.569 |
| 78 | ALA | 116 | CYS | 1.438 | 2.004 | -0.566 | 0.566 |
| 409 | ASN | 410 | ASP | 0.000 | 0.564 | -0.564 | 0.564 |
| 174 | TYR | 185 | TYR | 0.592 | 1.155 | -0.564 | 0.564 |
| 80 | LEU | 84 | LEU | 2.133 | 1.572 | 0.561 | 0.561 |
| 32 | TRP | 94 | ILE | 0.000 | 0.559 | -0.559 | 0.559 |
| 230 | LEU | 265 | CYS | 0.000 | 0.556 | -0.556 | 0.556 |
| 40 | MET | 91 | ALA | 2.415 | 2.965 | -0.550 | 0.550 |
| 295 | VAL | 303 | ILE | 0.675 | 0.126 | 0.549 | 0.549 |
| 283 | THR | 288 | PRO | 0.842 | 0.299 | 0.543 | 0.543 |
| 387 | PHE | 388 | VAL | 0.000 | 0.539 | -0.539 | 0.539 |
| 117 | VAL | 282 | PHE | 0.000 | 0.538 | -0.538 | 0.538 |
| 168 | PRO | 174 | TYR | 2.263 | 1.728 | 0.535 | 0.535 |
| 56 | THR | 60 | LYS | 1.652 | 1.121 | 0.531 | 0.531 |
| 165 | SER | 199 | TYR | 0.531 | 0.000 | 0.531 | 0.531 |
| 133 | PHE | 138 | PRO | 0.760 | 0.235 | 0.525 | 0.525 |
| 313 | TRP | 316 | TYR | 0.948 | 1.472 | -0.524 | 0.524 |
| 292 | VAL | 308 | TYR | 0.850 | 0.329 | 0.521 | 0.521 |
| 174 | TYR | 175 | ARG | 1.763 | 2.281 | -0.518 | 0.518 |
| 323 | PRO | 336 | PHE | 0.000 | 0.517 | -0.517 | 0.517 |
| 72 | ILE | 327 | CYS | 0.516 | 0.000 | 0.516 | 0.516 |
| 104 | PHE | 105 | TRP | 0.512 | 0.000 | 0.512 | 0.512 |
| 51 | ASN | 80 | LEU | 1.919 | 1.414 | 0.506 | 0.506 |
| 86 | VAL | 109 | TRP | 4.870 | 5.375 | -0.504 | 0.504 |
| 167 | LEU | 171 | MET | 0.000 | 0.503 | -0.503 | 0.503 |
| 96 | MET | 100 | THR | 1.073 | 1.573 | -0.500 | 0.500 |
| 203 | SER | 207 | SER | 0.000 | 0.496 | -0.496 | 0.496 |
| 109 | TRP | 110 | THR | 1.028 | 1.523 | -0.495 | 0.495 |
| 47 | ILE | 316 | TYR | 1.319 | 0.825 | 0.494 | 0.494 |
| 168 | PRO | 173 | TRP | 6.251 | 5.759 | 0.492 | 0.492 |
| 379 | GLU | 380 | ASP | 0.492 | 0.000 | 0.492 | 0.492 |
| 236 | SER | 240 | PHE | 0.000 | 0.490 | -0.490 | 0.490 |
| 85 | ALA | 109 | TRP | 1.366 | 1.852 | -0.487 | 0.487 |
| 176 | ALA | 196 | ASN | 1.646 | 2.132 | -0.486 | 0.486 |
| 71 | PHE | 123 | THR | 1.451 | 1.930 | -0.479 | 0.479 |
| 171 | MET | 173 | TRP | 4.219 | 3.740 | 0.479 | 0.479 |
| 164 | THR | 207 | SER | 0.000 | 0.478 | -0.478 | 0.478 |
| 282 | PHE | 283 | THR | 0.477 | 0.000 | 0.477 | 0.477 |
| 140 | LYS | 144 | LEU | 0.280 | 0.749 | -0.469 | 0.469 |
| 207 | SER | 290 | PHE | 0.469 | 0.000 | 0.469 | 0.469 |
| 193 | PHE | 199 | TYR | 0.409 | 0.877 | -0.468 | 0.468 |
| 303 | ILE | 307 | VAL | 0.621 | 1.089 | -0.468 | 0.468 |
| 155 | LEU | 159 | ILE | 1.277 | 0.810 | 0.467 | 0.467 |
| 51 | ASN | 76 | ALA | 5.542 | 5.077 | 0.465 | 0.465 |
| 58 | ILE | 65 | GLN | 1.771 | 2.235 | -0.464 | 0.464 |
| 204 | SER | 293 | ASN | 1.884 | 1.421 | 0.463 | 0.463 |
| 85 | ALA | 112 | ILE | 0.162 | 0.621 | -0.459 | 0.459 |
| 208 | PHE | 209 | TYR | 2.741 | 2.284 | 0.456 | 0.456 |
| 90 | GLY | 313 | TRP | 1.031 | 1.484 | -0.454 | 0.454 |
| 114 | VAL | 164 | THR | 0.453 | 0.000 | 0.453 | 0.453 |
| 145 | LEU | 149 | LYS | 0.452 | 0.000 | 0.452 | 0.452 |
| 67 | VAL | 145 | LEU | 1.744 | 2.187 | -0.442 | 0.442 |
| 164 | THR | 165 | SER | 0.000 | 0.439 | -0.439 | 0.439 |
| 132 | TYR | 221 | ARG | 1.243 | 0.807 | 0.436 | 0.436 |
| 284 | LEU | 314 | ILE | 0.434 | 0.000 | 0.434 | 0.434 |
| 169 | ILE | 174 | TYR | 5.939 | 5.505 | 0.434 | 0.434 |
| 304 | ARG | 306 | GLU | 2.211 | 2.644 | -0.433 | 0.433 |
| 200 | ALA | 293 | ASN | 1.076 | 0.643 | 0.433 | 0.433 |
| 78 | ALA | 119 | ALA | 0.631 | 0.200 | 0.431 | 0.431 |
| 60 | LYS | 61 | PHE | 0.690 | 0.265 | 0.425 | 0.425 |
| 109 | TRP | 191 | CYS | 0.733 | 1.157 | -0.424 | 0.424 |
| 173 | TRP | 199 | TYR | 0.122 | 0.547 | -0.424 | 0.424 |
| 223 | PHE | 269 | HIS | 0.000 | 0.424 | -0.424 | 0.424 |
| 122 | GLU | 157 | VAL | 5.077 | 4.654 | 0.423 | 0.423 |
| 99 | TRP | 190 | CYS | 0.351 | 0.774 | -0.422 | 0.422 |
| 124 | LEU | 318 | ASN | 0.420 | 0.000 | 0.420 | 0.420 |
| 286 | TRP | 315 | GLY | 9.075 | 9.492 | -0.417 | 0.417 |
| 61 | PHE | 63 | ARG | 0.000 | 0.415 | -0.415 | 0.415 |
| 193 | PHE | 308 | TYR | 0.833 | 0.419 | 0.414 | 0.414 |
| 293 | ASN | 308 | TYR | 3.308 | 2.896 | 0.411 | 0.411 |
| 54 | VAL | 336 | PHE | 1.491 | 1.902 | -0.411 | 0.411 |
| 108 | PHE | 112 | ILE | 2.535 | 2.945 | -0.410 | 0.410 |
| 133 | PHE | 141 | TYR | 2.873 | 2.465 | 0.407 | 0.407 |
| 48 | VAL | 80 | LEU | 1.522 | 1.919 | -0.397 | 0.397 |
| 244 | ASN | 248 | VAL | 0.000 | 0.396 | -0.396 | 0.396 |
| 302 | LEU | 303 | ILE | 0.586 | 0.981 | -0.394 | 0.394 |
| 206 | VAL | 211 | PRO | 2.016 | 2.408 | -0.392 | 0.392 |
| 121 | ILE | 211 | PRO | 1.934 | 2.326 | -0.392 | 0.392 |
| 143 | SER | 149 | LYS | 0.000 | 0.391 | -0.391 | 0.391 |
| 274 | THR | 278 | ILE | 0.469 | 0.081 | 0.389 | 0.389 |
| 100 | THR | 101 | PHE | 3.168 | 2.780 | 0.388 | 0.388 |
| 51 | ASN | 323 | PRO | 3.614 | 3.226 | 0.388 | 0.388 |
| 304 | ARG | 307 | VAL | 0.818 | 0.434 | 0.383 | 0.383 |
| 74 | SER | 123 | THR | 1.920 | 2.302 | -0.382 | 0.382 |
| 300 | ASP | 301 | ASN | 0.247 | 0.629 | -0.382 | 0.382 |
| 122 | GLU | 211 | PRO | 0.380 | 0.000 | 0.380 | 0.380 |
| 145 | LEU | 153 | ILE | 0.474 | 0.095 | 0.379 | 0.379 |
| 106 | CYS | 191 | CYS | 6.409 | 6.786 | -0.377 | 0.377 |
| 172 | HIS | 175 | ARG | 14.138 | 14.512 | -0.375 | 0.375 |
| 108 | PHE | 170 | GLN | 1.210 | 0.839 | 0.371 | 0.371 |
| 288 | PRO | 311 | LEU | 1.596 | 1.966 | -0.370 | 0.370 |
| 78 | ALA | 120 | SER | 1.311 | 0.941 | 0.370 | 0.370 |
| 43 | ILE | 313 | TRP | 0.558 | 0.189 | 0.369 | 0.369 |
| 82 | MET | 286 | TRP | 0.000 | 0.367 | -0.367 | 0.367 |
| 61 | PHE | 339 | LEU | 1.477 | 1.111 | 0.366 | 0.366 |
| 274 | THR | 413 | LEU | 0.366 | 0.000 | 0.366 | 0.366 |
| 82 | MET | 87 | VAL | 3.977 | 4.336 | -0.359 | 0.359 |
| 91 | ALA | 313 | TRP | 3.082 | 3.441 | -0.359 | 0.359 |
| 58 | ILE | 72 | ILE | 0.376 | 0.735 | -0.358 | 0.358 |
| 174 | TYR | 195 | THR | 3.162 | 3.518 | -0.356 | 0.356 |
| 112 | ILE | 166 | PHE | 1.583 | 1.229 | 0.354 | 0.354 |
| 63 | ARG | 338 | GLU | 0.000 | 0.352 | -0.352 | 0.352 |
| 209 | TYR | 290 | PHE | 3.659 | 4.010 | -0.351 | 0.351 |
| 326 | TYR | 336 | PHE | 0.000 | 0.348 | -0.348 | 0.348 |
| 176 | ALA | 181 | ALA | 1.028 | 1.375 | -0.347 | 0.347 |
| 212 | LEU | 279 | MET | 0.346 | 0.000 | 0.346 | 0.346 |
| 167 | LEU | 168 | PRO | 1.431 | 1.089 | 0.342 | 0.342 |
| 287 | LEU | 291 | ILE | 2.310 | 1.969 | 0.341 | 0.341 |
| 276 | GLY | 281 | THR | 0.339 | 0.000 | 0.339 | 0.339 |
| 75 | LEU | 278 | ILE | 0.000 | 0.338 | -0.338 | 0.338 |
| 166 | PHE | 170 | GLN | 0.176 | 0.507 | -0.332 | 0.332 |
| 55 | ILE | 73 | THR | 0.000 | 0.331 | -0.331 | 0.331 |
| 94 | ILE | 313 | TRP | 2.786 | 3.116 | -0.330 | 0.330 |
| 195 | THR | 199 | TYR | 1.486 | 1.813 | -0.326 | 0.326 |
| 234 | ASP | 260 | ARG | 0.324 | 0.000 | 0.324 | 0.324 |
| 20 | PRO | 21 | ASP | 0.000 | 0.324 | -0.324 | 0.324 |
| 109 | TRP | 316 | TYR | 0.017 | 0.340 | -0.323 | 0.323 |
| 63 | ARG | 64 | LEU | 0.000 | 0.322 | -0.322 | 0.322 |
| 322 | ASN | 326 | TYR | 1.002 | 0.684 | 0.319 | 0.319 |
| 354 | TYR | 355 | SER | 0.318 | 0.000 | 0.318 | 0.318 |
| 12 | LEU | 13 | ALA | 0.000 | 0.317 | -0.317 | 0.317 |
| 111 | SER | 170 | GLN | 2.338 | 2.023 | 0.314 | 0.314 |
| 174 | TYR | 196 | ASN | 6.626 | 6.315 | 0.312 | 0.312 |
| 44 | VAL | 87 | VAL | 1.543 | 1.234 | 0.310 | 0.310 |
| 176 | ALA | 182 | ILE | 0.007 | 0.316 | -0.309 | 0.309 |
| 204 | SER | 209 | TYR | 6.019 | 5.713 | 0.305 | 0.305 |
| 90 | GLY | 109 | TRP | 2.026 | 1.722 | 0.304 | 0.304 |
| 39 | VAL | 43 | ILE | 0.283 | 0.584 | -0.301 | 0.301 |
| 103 | ASN | 190 | CYS | 0.661 | 0.364 | 0.297 | 0.297 |
| 67 | VAL | 71 | PHE | 0.163 | 0.455 | -0.292 | 0.292 |
| 217 | PHE | 218 | VAL | 0.000 | 0.292 | -0.292 | 0.292 |
| 187 | ASN | 189 | THR | 4.222 | 4.512 | -0.291 | 0.291 |
| 67 | VAL | 150 | ALA | 0.662 | 0.372 | 0.290 | 0.290 |
| 226 | ALA | 269 | HIS | 0.000 | 0.281 | -0.281 | 0.281 |
| 227 | LYS | 231 | GLN | 1.494 | 1.215 | 0.279 | 0.279 |
| 394 | VAL | 395 | PRO | 2.117 | 2.395 | -0.278 | 0.278 |
| 67 | VAL | 147 | LYS | 0.807 | 0.531 | 0.276 | 0.276 |
| 51 | ASN | 79 | ASP | 4.674 | 4.949 | -0.275 | 0.275 |
| 289 | PHE | 311 | LEU | 3.214 | 3.485 | -0.272 | 0.272 |
| 52 | VAL | 80 | LEU | 1.146 | 0.877 | 0.269 | 0.269 |
| 68 | THR | 275 | LEU | 0.000 | 0.269 | -0.269 | 0.269 |
| 181 | ALA | 194 | PHE | 3.871 | 3.603 | 0.268 | 0.268 |
| 203 | SER | 204 | SER | 0.266 | 0.000 | 0.266 | 0.266 |
| 49 | PHE | 340 | LEU | 0.741 | 1.006 | -0.265 | 0.265 |
| 103 | ASN | 185 | TYR | 2.283 | 2.548 | -0.265 | 0.265 |
| 132 | TYR | 218 | VAL | 1.395 | 1.131 | 0.264 | 0.264 |
| 275 | LEU | 278 | ILE | 0.000 | 0.262 | -0.262 | 0.262 |
| 386 | ASP | 387 | PHE | 0.000 | 0.260 | -0.260 | 0.260 |
| 82 | MET | 116 | CYS | 2.654 | 2.395 | 0.259 | 0.259 |
| 363 | GLN | 364 | SER | 0.096 | 0.355 | -0.259 | 0.259 |
| 53 | LEU | 339 | LEU | 1.560 | 1.818 | -0.258 | 0.258 |
| 237 | GLU | 260 | ARG | 0.256 | 0.000 | 0.256 | 0.256 |
| 364 | SER | 366 | TYR | 0.000 | 0.255 | -0.255 | 0.255 |
| 55 | ILE | 80 | LEU | 0.782 | 0.529 | 0.253 | 0.253 |
| 103 | ASN | 186 | ALA | 1.056 | 0.809 | 0.247 | 0.247 |
| 406 | CYS | 408 | THR | 0.245 | 0.000 | 0.245 | 0.245 |
| 187 | ASN | 190 | CYS | 1.090 | 0.845 | 0.245 | 0.245 |
| 195 | THR | 200 | ALA | 1.558 | 1.313 | 0.245 | 0.245 |
| 209 | TYR | 294 | ILE | 2.447 | 2.202 | 0.245 | 0.245 |
| 317 | VAL | 321 | PHE | 2.352 | 2.110 | 0.243 | 0.243 |
| 193 | PHE | 195 | THR | 3.731 | 3.491 | 0.240 | 0.240 |
| 400 | ASP | 401 | SER | 0.104 | 0.343 | -0.239 | 0.239 |
| 71 | PHE | 153 | ILE | 0.883 | 1.119 | -0.237 | 0.237 |
| 262 | SER | 263 | LYS | 0.230 | 0.000 | 0.230 | 0.230 |
| 110 | THR | 169 | ILE | 1.417 | 1.646 | -0.229 | 0.229 |
| 74 | SER | 158 | TRP | 3.193 | 3.416 | -0.223 | 0.223 |
| 141 | TYR | 142 | GLN | 0.223 | 0.000 | 0.223 | 0.223 |
| 64 | LEU | 69 | ASN | 6.007 | 6.228 | -0.220 | 0.220 |
| 305 | LYS | 309 | ILE | 1.236 | 1.017 | 0.219 | 0.219 |
| 275 | LEU | 280 | GLY | 0.219 | 0.000 | 0.219 | 0.219 |
| 203 | SER | 208 | PHE | 0.052 | 0.271 | -0.219 | 0.219 |
| 107 | GLU | 172 | HIS | 5.953 | 5.735 | 0.218 | 0.218 |
| 128 | ALA | 215 | MET | 0.580 | 0.796 | -0.216 | 0.216 |
| 325 | ILE | 328 | ARG | 0.000 | 0.213 | -0.213 | 0.213 |
| 67 | VAL | 146 | THR | 0.091 | 0.303 | -0.212 | 0.212 |
| 81 | VAL | 116 | CYS | 1.562 | 1.773 | -0.211 | 0.211 |
| 244 | ASN | 247 | GLN | 0.000 | 0.207 | -0.207 | 0.207 |
| 111 | SER | 169 | ILE | 3.865 | 4.069 | -0.204 | 0.204 |
| 285 | CYS | 315 | GLY | 2.412 | 2.209 | 0.203 | 0.203 |
| 292 | VAL | 311 | LEU | 1.763 | 1.561 | 0.202 | 0.202 |
| 54 | VAL | 332 | PHE | 0.116 | 0.317 | -0.201 | 0.201 |
| 81 | VAL | 86 | VAL | 1.030 | 0.834 | 0.196 | 0.196 |
| 179 | GLN | 182 | ILE | 0.458 | 0.263 | 0.195 | 0.195 |
| 47 | ILE | 83 | GLY | 1.608 | 1.803 | -0.195 | 0.195 |
| 34 | VAL | 38 | ILE | 0.271 | 0.465 | -0.194 | 0.194 |
| 99 | TRP | 188 | GLU | 1.522 | 1.715 | -0.193 | 0.193 |
| 75 | LEU | 120 | SER | 2.936 | 2.743 | 0.193 | 0.193 |
| 81 | VAL | 112 | ILE | 0.550 | 0.741 | -0.192 | 0.192 |
| 396 | SER | 397 | ASP | 1.114 | 0.925 | 0.190 | 0.190 |
| 72 | ILE | 275 | LEU | 0.000 | 0.189 | -0.189 | 0.189 |
| 184 | CYS | 192 | ASP | 1.903 | 2.093 | -0.189 | 0.189 |
| 185 | TYR | 195 | THR | 0.046 | 0.233 | -0.188 | 0.188 |
| 43 | ILE | 47 | ILE | 0.745 | 0.931 | -0.186 | 0.186 |
| 124 | LEU | 215 | MET | 1.765 | 1.950 | -0.185 | 0.185 |
| 48 | VAL | 52 | VAL | 0.319 | 0.137 | 0.182 | 0.182 |
| 62 | GLU | 65 | GLN | 0.032 | 0.213 | -0.181 | 0.181 |
| 273 | LYS | 277 | ILE | 0.524 | 0.343 | 0.181 | 0.181 |
| 209 | TYR | 287 | LEU | 0.000 | 0.180 | -0.180 | 0.180 |
| 57 | ALA | 64 | LEU | 2.087 | 2.264 | -0.177 | 0.177 |
| 40 | MET | 95 | LEU | 0.171 | 0.347 | -0.176 | 0.176 |
| 82 | MET | 117 | VAL | 1.307 | 1.132 | 0.176 | 0.176 |
| 147 | LYS | 151 | ARG | 0.000 | 0.176 | -0.176 | 0.176 |
| 176 | ALA | 185 | TYR | 4.463 | 4.638 | -0.175 | 0.175 |
| 55 | ILE | 77 | CYS | 1.106 | 1.281 | -0.175 | 0.175 |
| 285 | CYS | 321 | PHE | 0.530 | 0.702 | -0.172 | 0.172 |
| 149 | LYS | 153 | ILE | 0.171 | 0.000 | 0.171 | 0.171 |
| 81 | VAL | 85 | ALA | 0.035 | 0.206 | -0.171 | 0.171 |
| 305 | LYS | 306 | GLU | 0.170 | 0.000 | 0.170 | 0.170 |
| 123 | THR | 154 | ILE | 0.166 | 0.000 | 0.166 | 0.166 |
| 114 | VAL | 169 | ILE | 0.555 | 0.390 | 0.165 | 0.165 |
| 322 | ASN | 325 | ILE | 0.000 | 0.165 | -0.165 | 0.165 |
| 136 | THR | 225 | GLU | 0.000 | 0.161 | -0.161 | 0.161 |
| 40 | MET | 94 | ILE | 1.644 | 1.805 | -0.161 | 0.161 |
| 184 | CYS | 191 | CYS | 0.382 | 0.542 | -0.160 | 0.160 |
| 107 | GLU | 170 | GLN | 2.257 | 2.101 | 0.157 | 0.157 |
| 222 | VAL | 275 | LEU | 0.156 | 0.000 | 0.156 | 0.156 |
| 105 | TRP | 109 | TRP | 0.000 | 0.156 | -0.156 | 0.156 |
| 68 | THR | 72 | ILE | 0.000 | 0.154 | -0.154 | 0.154 |
| 117 | VAL | 316 | TYR | 0.153 | 0.000 | 0.153 | 0.153 |
| 43 | ILE | 317 | VAL | 0.830 | 0.983 | -0.153 | 0.153 |
| 201 | ILE | 294 | ILE | 0.921 | 0.769 | 0.153 | 0.153 |
| 185 | TYR | 192 | ASP | 0.000 | 0.152 | -0.152 | 0.152 |
| 33 | VAL | 95 | LEU | 1.920 | 1.769 | 0.151 | 0.151 |
| 180 | GLU | 194 | PHE | 1.844 | 1.992 | -0.148 | 0.148 |
| 120 | SER | 319 | SER | 0.147 | 0.000 | 0.147 | 0.147 |
| 322 | ASN | 327 | CYS | 0.146 | 0.000 | 0.146 | 0.146 |
| 78 | ALA | 158 | TRP | 2.393 | 2.538 | -0.145 | 0.145 |
| 107 | GLU | 175 | ARG | 3.178 | 3.322 | -0.144 | 0.144 |
| 64 | LEU | 331 | ASP | 1.579 | 1.722 | -0.143 | 0.143 |
| 295 | VAL | 302 | LEU | 0.747 | 0.606 | 0.141 | 0.141 |
| 235 | LYS | 239 | ARG | 0.000 | 0.140 | -0.140 | 0.140 |
| 296 | HIS | 301 | ASN | 0.000 | 0.138 | -0.138 | 0.138 |
| 57 | ALA | 332 | PHE | 0.166 | 0.028 | 0.138 | 0.138 |
| 66 | THR | 69 | ASN | 4.431 | 4.293 | 0.138 | 0.138 |
| 143 | SER | 144 | LEU | 0.006 | 0.143 | -0.138 | 0.138 |
| 218 | VAL | 219 | TYR | 0.137 | 0.000 | 0.137 | 0.137 |
| 312 | ASN | 316 | TYR | 6.922 | 7.059 | -0.137 | 0.137 |
| 115 | LEU | 162 | GLY | 1.489 | 1.353 | 0.136 | 0.136 |
| 71 | PHE | 145 | LEU | 0.360 | 0.492 | -0.132 | 0.132 |
| 82 | MET | 88 | PRO | 0.533 | 0.401 | 0.132 | 0.132 |
| 285 | CYS | 286 | TRP | 0.225 | 0.094 | 0.132 | 0.132 |
| 124 | LEU | 127 | ILE | 0.000 | 0.131 | -0.131 | 0.131 |
| 321 | PHE | 325 | ILE | 0.451 | 0.319 | 0.131 | 0.131 |
| 321 | PHE | 324 | LEU | 0.012 | 0.143 | -0.131 | 0.131 |
| 199 | TYR | 204 | SER | 0.020 | 0.151 | -0.131 | 0.131 |
| 200 | ALA | 294 | ILE | 0.311 | 0.441 | -0.130 | 0.130 |
| 106 | CYS | 110 | THR | 0.350 | 0.222 | 0.128 | 0.128 |
| 201 | ILE | 205 | ILE | 0.856 | 0.728 | 0.128 | 0.128 |
| 277 | ILE | 281 | THR | 0.396 | 0.522 | -0.126 | 0.126 |
| 54 | VAL | 76 | ALA | 0.766 | 0.892 | -0.126 | 0.126 |
| 212 | LEU | 287 | LEU | 0.327 | 0.453 | -0.126 | 0.126 |
| 57 | ALA | 335 | ALA | 0.335 | 0.460 | -0.125 | 0.125 |
| 140 | LYS | 145 | LEU | 0.125 | 0.000 | 0.125 | 0.125 |
| 57 | ALA | 336 | PHE | 0.995 | 1.119 | -0.124 | 0.124 |
| 174 | TYR | 194 | PHE | 2.090 | 2.213 | -0.123 | 0.123 |
| 92 | ALA | 98 | MET | 0.000 | 0.123 | -0.123 | 0.123 |
| 57 | ALA | 61 | PHE | 0.025 | 0.147 | -0.122 | 0.122 |
| 216 | VAL | 279 | MET | 0.121 | 0.000 | 0.121 | 0.121 |
| 48 | VAL | 84 | LEU | 1.469 | 1.590 | -0.121 | 0.121 |
| 86 | VAL | 316 | TYR | 1.918 | 2.039 | -0.121 | 0.121 |
| 96 | MET | 98 | MET | 0.140 | 0.260 | -0.120 | 0.120 |
| 178 | HIS | 180 | GLU | 0.960 | 0.841 | 0.120 | 0.120 |
| 307 | VAL | 311 | LEU | 0.553 | 0.671 | -0.118 | 0.118 |
| 118 | THR | 122 | GLU | 1.370 | 1.487 | -0.117 | 0.117 |
| 126 | VAL | 157 | VAL | 0.602 | 0.488 | 0.115 | 0.115 |
| 69 | ASN | 72 | ILE | 0.974 | 1.089 | -0.115 | 0.115 |
| 173 | TRP | 196 | ASN | 2.701 | 2.587 | 0.114 | 0.114 |
| 160 | VAL | 164 | THR | 0.000 | 0.111 | -0.111 | 0.111 |
| 118 | THR | 161 | SER | 5.011 | 4.899 | 0.111 | 0.111 |
| 411 | SER | 412 | LEU | 0.000 | 0.110 | -0.110 | 0.110 |
| 54 | VAL | 323 | PRO | 1.238 | 1.132 | 0.106 | 0.106 |
| 281 | THR | 285 | CYS | 0.381 | 0.275 | 0.106 | 0.106 |
| 285 | CYS | 311 | LEU | 0.259 | 0.363 | -0.104 | 0.104 |
| 346 | SER | 347 | LEU | 0.213 | 0.315 | -0.102 | 0.102 |
| 152 | VAL | 156 | MET | 0.205 | 0.104 | 0.101 | 0.101 |
| 205 | ILE | 211 | PRO | 0.337 | 0.438 | -0.101 | 0.101 |
| 130 | ASP | 145 | LEU | 1.075 | 1.175 | -0.101 | 0.101 |
| 154 | ILE | 158 | TRP | 1.257 | 1.157 | 0.100 | 0.100 |
| 89 | PHE | 99 | TRP | 0.995 | 0.895 | 0.100 | 0.100 |
| 146 | THR | 148 | ASN | 0.487 | 0.388 | 0.100 | 0.100 |
| 45 | LEU | 50 | GLY | 0.046 | 0.145 | -0.099 | 0.099 |
| 110 | THR | 191 | CYS | 0.119 | 0.218 | -0.098 | 0.098 |
| 205 | ILE | 210 | VAL | 4.695 | 4.793 | -0.098 | 0.098 |
| 61 | PHE | 64 | LEU | 0.806 | 0.903 | -0.098 | 0.098 |
| 127 | ILE | 131 | ARG | 0.074 | 0.172 | -0.098 | 0.098 |
| 303 | ILE | 308 | TYR | 0.167 | 0.069 | 0.098 | 0.098 |
| 159 | ILE | 163 | LEU | 0.806 | 0.710 | 0.096 | 0.096 |
| 286 | TRP | 290 | PHE | 2.084 | 1.988 | 0.096 | 0.096 |
| 47 | ILE | 320 | GLY | 1.897 | 1.801 | 0.096 | 0.096 |
| 37 | GLY | 95 | LEU | 1.824 | 1.729 | 0.095 | 0.095 |
| 93 | HIS | 192 | ASP | 0.541 | 0.635 | -0.094 | 0.094 |
| 216 | VAL | 220 | SER | 0.202 | 0.296 | -0.094 | 0.094 |
| 215 | MET | 216 | VAL | 0.000 | 0.092 | -0.092 | 0.092 |
| 133 | PHE | 136 | THR | 0.092 | 0.000 | 0.092 | 0.092 |
| 47 | ILE | 51 | ASN | 0.644 | 0.736 | -0.092 | 0.092 |
| 54 | VAL | 72 | ILE | 0.451 | 0.542 | -0.091 | 0.091 |
| 58 | ILE | 332 | PHE | 2.085 | 1.997 | 0.089 | 0.089 |
| 128 | ALA | 218 | VAL | 2.680 | 2.593 | 0.087 | 0.087 |
| 86 | VAL | 112 | ILE | 1.452 | 1.539 | -0.086 | 0.086 |
| 233 | ILE | 236 | SER | 0.050 | 0.135 | -0.085 | 0.085 |
| 138 | PRO | 139 | PHE | 0.058 | 0.143 | -0.084 | 0.084 |
| 103 | ASN | 184 | CYS | 0.082 | 0.000 | 0.082 | 0.082 |
| 281 | THR | 321 | PHE | 1.653 | 1.735 | -0.082 | 0.082 |
| 169 | ILE | 170 | GLN | 0.252 | 0.333 | -0.081 | 0.081 |
| 197 | GLN | 298 | ILE | 0.000 | 0.080 | -0.080 | 0.080 |
| 233 | ILE | 262 | SER | 0.000 | 0.079 | -0.079 | 0.079 |
| 124 | LEU | 219 | TYR | 0.077 | 0.000 | 0.077 | 0.077 |
| 129 | VAL | 133 | PHE | 1.473 | 1.398 | 0.074 | 0.074 |
| 108 | PHE | 166 | PHE | 1.110 | 1.184 | -0.074 | 0.074 |
| 113 | ASP | 117 | VAL | 0.752 | 0.678 | 0.074 | 0.074 |
| 224 | GLN | 228 | ARG | 0.000 | 0.073 | -0.073 | 0.073 |
| 190 | CYS | 192 | ASP | 0.914 | 0.841 | 0.073 | 0.073 |
| 140 | LYS | 143 | SER | 0.000 | 0.073 | -0.073 | 0.073 |
| 121 | ILE | 125 | CYS | 0.000 | 0.073 | -0.073 | 0.073 |
| 55 | ILE | 76 | ALA | 1.914 | 1.842 | 0.072 | 0.072 |
| 47 | ILE | 79 | ASP | 1.378 | 1.449 | -0.071 | 0.071 |
| 36 | MET | 95 | LEU | 0.484 | 0.554 | -0.070 | 0.070 |
| 215 | MET | 326 | TYR | 0.070 | 0.000 | 0.070 | 0.070 |
| 225 | GLU | 232 | LYS | 0.069 | 0.000 | 0.069 | 0.069 |
| 44 | VAL | 88 | PRO | 1.859 | 1.928 | -0.069 | 0.069 |
| 247 | GLN | 248 | VAL | 0.069 | 0.000 | 0.069 | 0.069 |
| 355 | SER | 356 | SER | 0.067 | 0.000 | 0.067 | 0.067 |
| 366 | TYR | 367 | HIS | 0.000 | 0.067 | -0.067 | 0.067 |
| 163 | LEU | 167 | LEU | 0.260 | 0.194 | 0.065 | 0.065 |
| 291 | ILE | 295 | VAL | 0.268 | 0.203 | 0.065 | 0.065 |
| 197 | GLN | 201 | ILE | 1.425 | 1.360 | 0.065 | 0.065 |
| 184 | CYS | 194 | PHE | 1.434 | 1.498 | -0.064 | 0.064 |
| 175 | ARG | 194 | PHE | 0.238 | 0.175 | 0.063 | 0.063 |
| 126 | VAL | 153 | ILE | 1.177 | 1.241 | -0.063 | 0.063 |
| 82 | MET | 113 | ASP | 1.162 | 1.099 | 0.062 | 0.062 |
| 214 | ILE | 218 | VAL | 0.440 | 0.379 | 0.062 | 0.062 |
| 58 | ILE | 73 | THR | 3.198 | 3.260 | -0.061 | 0.061 |
| 71 | PHE | 154 | ILE | 2.380 | 2.441 | -0.061 | 0.061 |
| 178 | HIS | 181 | ALA | 2.706 | 2.767 | -0.061 | 0.061 |
| 73 | THR | 77 | CYS | 0.171 | 0.232 | -0.061 | 0.061 |
| 218 | VAL | 222 | VAL | 0.168 | 0.108 | 0.061 | 0.061 |
| 329 | SER | 330 | PRO | 1.080 | 1.020 | 0.060 | 0.060 |
| 43 | ILE | 87 | VAL | 0.133 | 0.193 | -0.059 | 0.059 |
| 298 | ILE | 299 | GLN | 0.287 | 0.347 | -0.059 | 0.059 |
| 287 | LEU | 288 | PRO | 0.870 | 0.928 | -0.058 | 0.058 |
| 125 | CYS | 129 | VAL | 0.057 | 0.000 | 0.057 | 0.057 |
| 236 | SER | 237 | GLU | 0.000 | 0.055 | -0.055 | 0.055 |
| 166 | PHE | 171 | MET | 0.120 | 0.066 | 0.054 | 0.054 |
| 156 | MET | 159 | ILE | 0.000 | 0.053 | -0.053 | 0.053 |
| 119 | ALA | 161 | SER | 4.173 | 4.225 | -0.053 | 0.053 |
| 53 | LEU | 340 | LEU | 0.893 | 0.944 | -0.051 | 0.051 |
| 32 | TRP | 33 | VAL | 0.400 | 0.451 | -0.051 | 0.051 |
| 14 | PRO | 15 | ASN | 0.050 | 0.000 | 0.050 | 0.050 |
| 123 | THR | 127 | ILE | 0.390 | 0.440 | -0.049 | 0.049 |
| 87 | VAL | 316 | TYR | 1.413 | 1.461 | -0.048 | 0.048 |
| 311 | LEU | 314 | ILE | 0.344 | 0.392 | -0.047 | 0.047 |
| 44 | VAL | 83 | GLY | 1.045 | 0.998 | 0.047 | 0.047 |
| 210 | VAL | 214 | ILE | 0.497 | 0.543 | -0.046 | 0.046 |
| 22 | HIS | 25 | THR | 0.048 | 0.094 | -0.046 | 0.046 |
| 92 | ALA | 96 | MET | 0.000 | 0.045 | -0.045 | 0.045 |
| 195 | THR | 297 | VAL | 0.089 | 0.134 | -0.045 | 0.045 |
| 54 | VAL | 58 | ILE | 0.534 | 0.490 | 0.045 | 0.045 |
| 64 | LEU | 335 | ALA | 0.656 | 0.612 | 0.044 | 0.044 |
| 322 | ASN | 323 | PRO | 0.889 | 0.932 | -0.042 | 0.042 |
| 181 | ALA | 185 | TYR | 1.831 | 1.788 | 0.042 | 0.042 |
| 329 | SER | 331 | ASP | 0.537 | 0.578 | -0.042 | 0.042 |
| 282 | PHE | 287 | LEU | 0.121 | 0.080 | 0.041 | 0.041 |
| 113 | ASP | 316 | TYR | 6.547 | 6.587 | -0.040 | 0.040 |
| 27 | GLU | 31 | VAL | 0.000 | 0.039 | -0.039 | 0.039 |
| 52 | VAL | 56 | THR | 0.444 | 0.482 | -0.038 | 0.038 |
| 196 | ASN | 198 | ALA | 0.742 | 0.778 | -0.036 | 0.036 |
| 172 | HIS | 174 | TYR | 0.069 | 0.104 | -0.036 | 0.036 |
| 94 | ILE | 309 | ILE | 1.054 | 1.018 | 0.035 | 0.035 |
| 134 | ALA | 412 | LEU | 0.035 | 0.000 | 0.035 | 0.035 |
| 230 | LEU | 269 | HIS | 0.000 | 0.033 | -0.033 | 0.033 |
| 112 | ILE | 116 | CYS | 0.554 | 0.522 | 0.032 | 0.032 |
| 83 | GLY | 88 | PRO | 2.961 | 2.994 | -0.032 | 0.032 |
| 176 | ALA | 178 | HIS | 1.577 | 1.545 | 0.032 | 0.032 |
| 49 | PHE | 53 | LEU | 0.109 | 0.078 | 0.031 | 0.031 |
| 212 | LEU | 216 | VAL | 0.660 | 0.631 | 0.030 | 0.030 |
| 219 | TYR | 273 | LYS | 0.000 | 0.029 | -0.029 | 0.029 |
| 72 | ILE | 332 | PHE | 0.266 | 0.237 | 0.029 | 0.029 |
| 68 | THR | 69 | ASN | 0.030 | 0.058 | -0.029 | 0.029 |
| 87 | VAL | 88 | PRO | 0.885 | 0.913 | -0.028 | 0.028 |
| 38 | ILE | 42 | LEU | 0.451 | 0.424 | 0.027 | 0.027 |
| 119 | ALA | 157 | VAL | 0.949 | 0.923 | 0.026 | 0.026 |
| 106 | CYS | 190 | CYS | 0.165 | 0.190 | -0.026 | 0.026 |
| 132 | TYR | 137 | SER | 0.025 | 0.000 | 0.025 | 0.025 |
| 109 | TRP | 113 | ASP | 0.024 | 0.000 | 0.024 | 0.024 |
| 75 | LEU | 326 | TYR | 0.707 | 0.683 | 0.024 | 0.024 |
| 46 | ALA | 51 | ASN | 0.000 | 0.023 | -0.023 | 0.023 |
| 114 | VAL | 118 | THR | 0.479 | 0.502 | -0.023 | 0.023 |
| 57 | ALA | 339 | LEU | 1.898 | 1.875 | 0.023 | 0.023 |
| 24 | VAL | 28 | ARG | 0.000 | 0.022 | -0.022 | 0.022 |
| 51 | ASN | 319 | SER | 2.310 | 2.332 | -0.022 | 0.022 |
| 113 | ASP | 286 | TRP | 0.000 | 0.021 | -0.021 | 0.021 |
| 137 | SER | 138 | PRO | 0.122 | 0.102 | 0.020 | 0.020 |
| 60 | LYS | 339 | LEU | 0.626 | 0.645 | -0.019 | 0.019 |
| 326 | TYR | 333 | ARG | 0.000 | 0.018 | -0.018 | 0.018 |
| 123 | THR | 157 | VAL | 0.924 | 0.941 | -0.018 | 0.018 |
| 137 | SER | 140 | LYS | 0.602 | 0.585 | 0.017 | 0.017 |
| 66 | THR | 68 | THR | 0.255 | 0.238 | 0.017 | 0.017 |
| 200 | ALA | 297 | VAL | 1.384 | 1.401 | -0.017 | 0.017 |
| 205 | ILE | 209 | TYR | 0.210 | 0.194 | 0.016 | 0.016 |
| 92 | ALA | 97 | LYS | 0.005 | 0.020 | -0.015 | 0.015 |
| 214 | ILE | 219 | TYR | 0.000 | 0.015 | -0.015 | 0.015 |
| 86 | VAL | 116 | CYS | 0.000 | 0.015 | -0.015 | 0.015 |
| 102 | GLY | 188 | GLU | 2.266 | 2.281 | -0.015 | 0.015 |
| 125 | CYS | 212 | LEU | 0.000 | 0.014 | -0.014 | 0.014 |
| 56 | THR | 339 | LEU | 1.478 | 1.464 | 0.014 | 0.014 |
| 115 | LEU | 119 | ALA | 0.000 | 0.013 | -0.013 | 0.013 |
| 88 | PRO | 89 | PHE | 0.000 | 0.012 | -0.012 | 0.012 |
| 153 | ILE | 157 | VAL | 0.000 | 0.011 | -0.011 | 0.011 |
| 240 | PHE | 244 | ASN | 0.000 | 0.011 | -0.011 | 0.011 |
| 227 | LYS | 264 | PHE | 0.010 | 0.000 | 0.010 | 0.010 |
| 47 | ILE | 87 | VAL | 0.383 | 0.390 | -0.008 | 0.008 |
| 294 | ILE | 298 | ILE | 0.781 | 0.773 | 0.008 | 0.008 |
| 204 | SER | 294 | ILE | 1.469 | 1.476 | -0.007 | 0.007 |
| 310 | LEU | 314 | ILE | 0.148 | 0.141 | 0.007 | 0.007 |
| 215 | MET | 220 | SER | 0.020 | 0.014 | 0.006 | 0.006 |
| 309 | ILE | 313 | TRP | 1.185 | 1.179 | 0.006 | 0.006 |
| 175 | ARG | 196 | ASN | 4.480 | 4.475 | 0.005 | 0.005 |
| 68 | THR | 127 | ILE | 0.000 | 0.004 | -0.004 | 0.004 |
| 115 | LEU | 158 | TRP | 0.995 | 0.998 | -0.002 | 0.002 |
| 157 | VAL | 161 | SER | 0.321 | 0.319 | 0.002 | 0.002 |
| 113 | ASP | 312 | ASN | 0.384 | 0.382 | 0.002 | 0.002 |
| 176 | ALA | 195 | THR | 2.020 | 2.022 | -0.002 | 0.002 |
| 210 | VAL | 211 | PRO | 1.495 | 1.494 | 0.001 | 0.001 |
| 44 | VAL | 48 | VAL | 0.203 | 0.203 | -0.000 | 0.000 |
RRCS change distribution
-0.10
Mean ΔRRCS
1.41
Std Dev
-0.05
Median
Magnitude classification
15
High (|Δ| ≥ 5.0)
57
Medium (2.0 ≤ |Δ| < 5.0)
628
Low (|Δ| < 2.0)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 1.97, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar