DRD2
699
Total Contact Pairs
75
Significant Changes
12.59
Max Increase
-7.81
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | TRP90 (2.60x59) | HIS106 (3.24x24) | 12.725 | 0.134 | +12.592 | HIGH |
| 2 | THR427 (7.54x54) | PHE433 (8.50x50) | 8.818 | 0.000 | +8.818 | HIGH |
| 3 | THR69 (2.39x39) | ARG132 (3.50x50) | 0.000 | 7.814 | -7.814 | HIGH |
| 4 | HIS302 | HIS303 | 0.000 | 7.675 | -7.675 | HIGH |
| 5 | ARG222 (5.71x71) | GLU280 | 0.000 | 7.613 | -7.613 | HIGH |
| 6 | GLU14 | ARG15 | 0.000 | 7.402 | -7.402 | HIGH |
| 7 | TRP386 (6.48x48) | GLY415 (7.42x41) | 2.014 | 9.191 | -7.178 | HIGH |
| 8 | ASN396 (6.58x58) | TYR408 (7.35x34) | 6.573 | 0.000 | +6.573 | HIGH |
| 9 | THR428 (7.55x55) | ARG434 (8.51x51) | 5.634 | 0.000 | +5.634 | HIGH |
| 10 | PHE341 | ILE343 | 5.362 | 0.000 | +5.362 | HIGH |
| 11 | ARG104 (3.22x22) | ALA177 | 0.713 | 5.961 | -5.248 | HIGH |
| 12 | TYR209 (5.58x58) | LEU375 (6.37x37) | 2.099 | 7.253 | -5.154 | HIGH |
| 13 | ASP131 (3.49x49) | TYR142 (34.53x53) | 3.820 | 8.890 | -5.070 | HIGH |
| 14 | HIS303 | GLN304 | 0.000 | 5.048 | -5.048 | HIGH |
| 15 | THR392 (6.54x54) | TYR408 (7.35x34) | 5.228 | 0.181 | +5.047 | HIGH |
| 16 | ASP131 (3.49x49) | ARG132 (3.50x50) | 0.000 | 5.029 | -5.029 | HIGH |
| 17 | GLU62 (1.60x60) | LYS439 (8.56x56) | 5.037 | 0.196 | +4.841 | MED |
| 18 | ASN418 (7.45x45) | ASN422 (7.49x49) | 5.252 | 0.472 | +4.780 | MED |
| 19 | ARG31 (1.29x29) | VAL97 (2.67x66) | 4.749 | 0.000 | +4.749 | MED |
| 20 | ARG220 (5.69x69) | GLU368 (6.30x30) | 4.662 | 0.000 | +4.662 | MED |
| 21 | ARG233 | GLU280 | 4.541 | 0.000 | +4.541 | MED |
| 22 | VAL265 | ARG269 | 0.000 | 4.235 | -4.235 | MED |
| 23 | TRP386 (6.48x48) | ASN418 (7.45x45) | 6.181 | 2.153 | +4.028 | MED |
| 24 | TYR37 (1.35x35) | GLU95 (2.65x64) | 0.180 | 4.113 | -3.933 | MED |
| 25 | ASN175 | ALA185 | 3.966 | 0.133 | +3.834 | MED |
| 26 | THR428 (7.55x55) | PHE429 (7.56x56) | 0.000 | 3.643 | -3.643 | MED |
| 27 | THR427 (7.54x54) | ARG434 (8.51x51) | 0.000 | 3.602 | -3.602 | MED |
| 28 | ASN5 | SER7 | 3.584 | 0.000 | +3.584 | MED |
| 29 | PHE382 (6.44x44) | ASN418 (7.45x45) | 0.000 | 3.439 | -3.439 | MED |
| 30 | ARG132 (3.50x50) | TYR142 (34.53x53) | 0.000 | 3.414 | -3.414 | MED |
| 31 | ARG104 (3.22x22) | ASN175 | 0.000 | 3.414 | -3.414 | MED |
| 32 | ASN175 | ILE183 (45.51x51) | 3.741 | 0.381 | +3.359 | MED |
| 33 | ARG132 (3.50x50) | TYR209 (5.58x58) | 3.348 | 0.000 | +3.348 | MED |
| 34 | ILE122 (3.40x40) | TRP386 (6.48x48) | 3.271 | 0.000 | +3.271 | MED |
| 35 | PHE202 (5.51x51) | PHE382 (6.44x44) | 3.247 | 0.000 | +3.247 | MED |
| 36 | LEU125 (3.43x43) | TYR426 (7.53x53) | 3.244 | 0.000 | +3.244 | MED |
| 37 | GLN16 | TRP18 | 3.476 | 0.238 | +3.238 | MED |
| 38 | VAL378 (6.40x40) | TYR426 (7.53x53) | 3.364 | 0.132 | +3.232 | MED |
| 39 | PHE198 (5.47x47) | PHE202 (5.51x51) | 3.159 | 0.000 | +3.159 | MED |
| 40 | PHE341 | LEU355 | 0.000 | 3.126 | -3.126 | MED |
| 41 | ARG132 (3.50x50) | LEU375 (6.37x37) | 0.000 | 3.119 | -3.119 | MED |
| 42 | ILE73 (2.43x43) | TYR426 (7.53x53) | 0.863 | 3.954 | -3.091 | MED |
| 43 | VAL136 (3.54x54) | ARG219 (5.68x68) | 2.542 | 5.566 | -3.024 | MED |
| 44 | PHE382 (6.44x44) | TRP386 (6.48x48) | 2.339 | 5.339 | -2.999 | MED |
| 45 | VAL115 | SER167 | 0.486 | 3.476 | -2.990 | MED |
| 46 | LYS339 | GLU342 | 0.000 | 2.968 | -2.968 | MED |
| 47 | VAL190 | HIS393 | 5.917 | 3.022 | +2.895 | MED |
| 48 | ARG31 (1.29x29) | TYR34 | 2.894 | 0.000 | +2.894 | MED |
| 49 | ARG132 (3.50x50) | TYR426 (7.53x53) | 2.881 | 0.000 | +2.881 | MED |
| 50 | TYR93 | LYS101 | 1.068 | 3.947 | -2.879 | MED |
| 51 | LEU41 | TRP413 | 11.114 | 8.252 | +2.862 | MED |
| 52 | TYR199 | ILE394 | 5.087 | 2.246 | +2.841 | MED |
| 53 | LYS339 | ILE340 | 2.820 | 0.000 | +2.820 | MED |
| 54 | ILE377 | PHE429 (7.56x56) | 0.000 | 2.675 | -2.675 | MED |
| 55 | THR119 | SER163 | 1.785 | 4.442 | -2.657 | MED |
| 56 | LEU4 | ASN5 | 0.000 | 2.649 | -2.649 | MED |
| 57 | HIS312 | HIS313 | 5.338 | 7.954 | -2.616 | MED |
| 58 | TYR209 (5.58x58) | VAL378 (6.40x40) | 2.602 | 0.000 | +2.602 | MED |
| 59 | TYR34 | TYR36 | 0.000 | 2.576 | -2.576 | MED |
| 60 | TYR142 (34.53x53) | ARG151 | 3.282 | 5.832 | -2.550 | MED |
| 61 | SER229 | ARG233 | 2.526 | 0.012 | +2.514 | MED |
| 62 | PRO139 | ARG219 (5.68x68) | 0.000 | 2.513 | -2.513 | MED |
| 63 | SER364 | GLU368 (6.30x30) | 0.085 | 2.591 | -2.505 | MED |
| 64 | ALA137 | ARG219 (5.68x68) | 0.000 | 2.503 | -2.503 | MED |
| 65 | LYS367 | GLU432 | 0.000 | 2.468 | -2.468 | MED |
| 66 | MET88 | TYR416 | 0.852 | 3.308 | -2.456 | MED |
| 67 | ASN70 | PHE433 (8.50x50) | 3.650 | 1.195 | +2.454 | MED |
| 68 | CYS399 | CYS401 | 1.173 | 3.605 | -2.433 | MED |
| 69 | VAL55 | THR427 (7.54x54) | 2.357 | 0.000 | +2.357 | MED |
| 70 | GLY51 | PRO423 | 1.751 | 4.097 | -2.346 | MED |
| 71 | ALA127 | MET155 | 0.386 | 2.726 | -2.340 | MED |
| 72 | TYR142 (34.53x53) | SER148 | 2.974 | 0.679 | +2.296 | MED |
| 73 | TRP100 | CYS182 | 6.712 | 4.420 | +2.292 | MED |
| 74 | PHE50 | LEU54 | 0.024 | 2.305 | -2.281 | MED |
| 75 | THR134 | ARG151 | 2.278 | 0.000 | +2.278 | MED |
| 76 | ARG104 (3.22x22) | ASN176 | 0.103 | 2.300 | -2.197 | LOW |
| 77 | THR112 | LEU171 | 2.986 | 5.176 | -2.190 | LOW |
| 78 | ARG31 (1.29x29) | VAL96 | 2.189 | 0.000 | +2.189 | LOW |
| 79 | TYR426 (7.53x53) | PHE433 (8.50x50) | 0.000 | 2.184 | -2.184 | LOW |
| 80 | LEU307 | PRO308 | 2.150 | 0.000 | +2.150 | LOW |
| 81 | LEU76 | SER121 | 1.838 | 3.924 | -2.086 | LOW |
| 82 | ILE424 | PHE429 (7.56x56) | 2.083 | 0.000 | +2.083 | LOW |
| 83 | SER129 | TYR209 (5.58x58) | 2.945 | 4.979 | -2.034 | LOW |
| 84 | LEU170 | PHE189 | 5.625 | 3.607 | +2.018 | LOW |
| 85 | ASN422 (7.49x49) | TYR426 (7.53x53) | 0.455 | 2.458 | -2.004 | LOW |
| 86 | ASP108 | ASN175 | 1.368 | 3.358 | -1.990 | LOW |
| 87 | LEU379 | ILE383 | 0.000 | 1.978 | -1.978 | LOW |
| 88 | SER311 | HIS312 | 3.217 | 5.187 | -1.970 | LOW |
| 89 | PHE389 | TYR408 (7.35x34) | 0.050 | 1.987 | -1.937 | LOW |
| 90 | THR351 | THR353 | 1.926 | 0.000 | +1.926 | LOW |
| 91 | THR112 | SER167 | 4.636 | 2.719 | +1.917 | LOW |
| 92 | ILE343 | THR345 | 2.082 | 0.180 | +1.902 | LOW |
| 93 | SER103 | HIS106 (3.24x24) | 0.731 | 2.621 | -1.889 | LOW |
| 94 | ASP80 | ASN422 (7.49x49) | 4.894 | 3.031 | +1.863 | LOW |
| 95 | ASN52 | ALA77 | 6.146 | 4.291 | +1.855 | LOW |
| 96 | TRP90 (2.60x59) | PHE110 | 2.485 | 4.326 | -1.841 | LOW |
| 97 | ASN396 (6.58x58) | ILE403 | 3.518 | 1.709 | +1.810 | LOW |
| 98 | ASN17 | SER19 | 1.806 | 0.000 | +1.806 | LOW |
| 99 | PRO297 | ILE298 | 0.000 | 1.784 | -1.784 | LOW |
| 100 | ARG31 (1.29x29) | GLY98 | 1.784 | 0.000 | +1.784 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.21 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 31-62 | 62 (4.8), 31 (4.7) | 2 | 37 (-3.9) | 1 |
| TM2 | 69-97 | 90 (12.6), 97 (4.7) | 2 | 69 (-7.8), 95 (-3.9), 73 (-3.1) | 3 |
| TM3 | 104-136 | 106 (12.6), 122 (3.3), 125 (3.2) | 3 | 132 (-7.8), 104 (-5.2), 131 (-5.1), 136 (-3.0) | 4 |
| TM4 | - | - | 0 | - | 0 |
| TM5 | 198-222 | 220 (4.7), 202 (3.2), 198 (3.2) | 3 | 222 (-7.6), 209 (-5.2), 219 (-3.0) | 3 |
| TM6 | 368-396 | 396 (6.6), 392 (5.0), 368 (4.7), 378 (3.2) | 4 | 386 (-7.2), 375 (-5.2), 382 (-3.4) | 3 |
| TM7 | 408-429 | 427 (8.8), 408 (6.6), 428 (5.6), 418 (4.8), 422 (4.8), 426 (3.2) | 6 | 415 (-7.2), 429 (-3.6) | 2 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | - | - | 0 | - | 0 |
| ICL2 | 142-142 | - | 0 | 142 (-5.1) | 1 |
| ICL3 | 233-355 | 341 (5.4), 343 (5.4), 233 (4.5) | 3 | 302 (-7.7), 303 (-7.7), 280 (-7.6), 304 (-5.0), 265 (-4.2), 269 (-4.2), 355 (-3.1) | 7 |
| ECL1 | - | - | 0 | - | 0 |
| ECL2 | 175-185 | 175 (3.8), 185 (3.8), 183 (3.4) | 3 | 177 (-5.2) | 1 |
| ECL3 | - | - | 0 | - | 0 |
| H8 | 433-439 | 433 (8.8), 434 (5.6), 439 (4.8) | 3 | - | 0 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
49 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 132 | p.Arg132Ser | c.396G>T | 6.84e-07 | 1 / 0 | 7.81 | 1.000 | PATHOGENIC | 0.95 | |
| 303 | p.His303Asp | c.907C>G | 6.84e-07 | 1 / 0 | 7.67 | 0.096 | BENIGN | 0.49 | rs1950782257 |
| 302 | p.His302Pro | c.905A>C | 6.59e-06 | 1 / 0 | 7.67 | 0.069 | BENIGN | 0.39 | rs1591272542 |
| 222 | p.Arg222Pro | c.665G>C | 6.84e-07 | 1 / 0 | 7.61 | 0.910 | PATHOGENIC | 0.86 | rs750647475 |
| 280 | p.Glu280Ala | c.839A>C | 6.85e-07 | 1 / 0 | 7.61 | 0.269 | BENIGN | 0.52 | |
| 280 | p.Glu280Lys | c.838G>A | 6.16e-06 | 9 / 0 | 7.61 | - | nan | - | rs1950783306 |
| 222 | p.Arg222Gln | c.665G>A | 1.30e-05 | 19 / 0 | 7.61 | - | nan | - | rs750647475 |
| 222 | p.Arg222Gly | c.664C>G | 1.37e-06 | 2 / 0 | 7.61 | - | nan | - | |
| 14 | p.Glu14Gln | c.40G>C | 6.84e-07 | 1 / 0 | 7.40 | 0.074 | BENIGN | 0.44 | |
| 408 | p.Tyr408Cys | c.1223A>G | 6.84e-07 | 1 / 0 | 6.57 | 0.927 | PATHOGENIC | 0.88 | rs1445212166 |
| 434 | p.Arg434Leu | c.1301G>T | 6.84e-07 | 1 / 0 | 5.63 | 0.998 | PATHOGENIC | 1.00 | |
| 434 | p.Arg434His | c.1301G>A | 2.74e-06 | 4 / 0 | 5.63 | - | nan | - | rs1195929717 |
| 434 | p.Arg434Cys | c.1300C>T | 1.37e-06 | 2 / 0 | 5.63 | - | nan | - | |
| 341 | p.Phe341Ser | c.1022T>C | 6.84e-07 | 1 / 0 | 5.36 | 0.594 | PATHOGENIC | 0.52 | |
| 343 | p.Ile343Thr | c.1028T>C | 6.84e-07 | 1 / 0 | 5.36 | 0.392 | AMBIGUOUS | 0.58 | |
| 104 | p.Arg104Ser | c.312G>C | 6.84e-07 | 1 / 0 | 5.25 | 0.384 | AMBIGUOUS | 0.63 | |
| 177 | p.Ala177Thr | c.529G>A | 2.53e-05 | 37 / 0 | 5.25 | 0.054 | BENIGN | 0.68 | rs571869697 |
| 131 | p.Asp131Asn | c.391G>A | 6.84e-07 | 1 / 0 | 5.07 | 0.998 | PATHOGENIC | 0.93 | rs549053606 |
| 304 | p.Gln304Lys | c.910C>A | 8.21e-06 | 12 / 0 | 5.05 | 0.090 | BENIGN | 0.56 | |
| 392 | p.Thr392Arg | c.1175C>G | 6.85e-07 | 1 / 0 | 5.05 | 0.943 | PATHOGENIC | 0.83 | |
| 62 | p.Glu62Asp | c.186G>C | 6.84e-07 | 1 / 0 | 4.84 | 0.901 | PATHOGENIC | 1.00 | rs1950918416 |
| 62 | p.Glu62Lys | c.184G>A | 6.84e-07 | 1 / 0 | 4.84 | - | nan | - | rs868401982 |
| 422 | p.Asn422Thr | c.1265A>C | 6.85e-06 | 1 / 0 | 4.78 | 0.997 | PATHOGENIC | 1.00 | rs1591270955 |
| 97 | p.Val97Ala | c.290T>C | 1.37e-06 | 2 / 0 | 4.75 | 0.152 | BENIGN | 0.66 | rs1231059179 |
| 31 | p.Arg31Ile | c.92G>T | 6.84e-07 | 1 / 0 | 4.75 | 0.096 | BENIGN | 0.62 | |
| 97 | p.Gly97Arg | c.289G>C | 6.84e-07 | 1 / 0 | 4.75 | - | nan | - | rs907486029 |
| 31 | p.Arg31Gly | c.91A>G | 1.37e-06 | 2 / 0 | 4.75 | - | nan | - | |
| 368 | p.Glu368Asp | c.1104G>C | 3.42e-06 | 5 / 0 | 4.66 | 0.993 | PATHOGENIC | 1.00 | rs890174542 |
| 220 | p.Arg220His | c.659G>A | 1.71e-05 | 25 / 0 | 4.66 | 0.304 | BENIGN | 0.67 | rs557036496 |
| 368 | p.Glu368Ala | c.1103A>C | 6.57e-06 | 1 / 0 | 4.66 | - | nan | - | rs1393695476 |
| 368 | p.Glu368Gly | c.1103A>G | 6.84e-07 | 1 / 0 | 4.66 | - | nan | - | |
| 220 | p.Arg220Leu | c.659G>T | 6.84e-07 | 1 / 0 | 4.66 | - | nan | - | |
| 220 | p.Arg220Cys | c.658C>T | 1.37e-06 | 2 / 0 | 4.66 | - | nan | - | rs755559594 |
| 220 | p.Arg220Ser | c.658C>A | 6.84e-07 | 1 / 0 | 4.66 | - | nan | - | |
| 269 | p.Arg269Lys | c.806G>A | 6.16e-06 | 9 / 0 | 4.24 | 0.071 | BENIGN | 0.54 | rs146652676 |
| 269 | p.Arg269Thr | c.806G>C | 6.57e-06 | 1 / 0 | 4.24 | - | nan | - | rs146652676 |
| 37 | p.Tyr37Cys | c.110A>G | 4.79e-06 | 7 / 0 | 3.93 | 0.475 | AMBIGUOUS | 0.94 | rs752405585 |
| 37 | p.Tyr37His | c.109T>C | 6.84e-07 | 1 / 0 | 3.93 | - | nan | - | |
| 175 | p.Asn175Ser | c.524A>G | 6.84e-07 | 1 / 0 | 3.83 | 0.428 | AMBIGUOUS | 0.95 | rs761794375 |
| 175 | p.Asn175Asp | c.523A>G | 6.84e-07 | 1 / 0 | 3.83 | - | nan | - | rs769717591 |
| 7 | p.Ser7Phe | c.20C>T | 1.37e-06 | 2 / 0 | 3.58 | 0.160 | BENIGN | 0.89 | rs780510016 |
| 183 | p.Ile183Asn | c.548T>A | 1.37e-06 | 2 / 0 | 3.36 | 0.209 | BENIGN | 0.52 | rs1203831599 |
| 183 | p.Ile183Phe | c.547A>T | 1.37e-06 | 2 / 0 | 3.36 | - | nan | - | rs938621123 |
| 16 | p.Gln16His | c.48G>C | 2.05e-06 | 3 / 0 | 3.24 | 0.101 | BENIGN | 0.53 | rs759561000 |
| 355 | p.Leu355Val | c.1063C>G | 6.57e-06 | 1 / 0 | 3.13 | 0.084 | BENIGN | 0.67 | rs1950779963 |
| 73 | p.Ile73Met | c.219C>G | 6.84e-07 | 1 / 0 | 3.09 | 0.905 | PATHOGENIC | 0.84 | |
| 136 | p.Val136Ala | c.407T>C | 6.84e-07 | 1 / 0 | 3.02 | 0.986 | PATHOGENIC | 0.96 | |
| 219 | p.Arg219His | c.656G>A | 6.84e-07 | 1 / 0 | 3.02 | 0.725 | PATHOGENIC | 0.87 | rs200148328 |
| 219 | p.Arg219Cys | c.655C>T | 4.79e-06 | 7 / 0 | 3.02 | - | nan | - | rs987305741 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.21, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 90 | TRP | 106 | HIS | 12.725 | 0.134 | 12.592 | 12.592 |
| 427 | THR | 433 | PHE | 8.818 | 0.000 | 8.818 | 8.818 |
| 69 | THR | 132 | ARG | 0.000 | 7.814 | -7.814 | 7.814 |
| 302 | HIS | 303 | HIS | 0.000 | 7.675 | -7.675 | 7.675 |
| 222 | ARG | 280 | GLU | 0.000 | 7.613 | -7.613 | 7.613 |
| 14 | GLU | 15 | ARG | 0.000 | 7.402 | -7.402 | 7.402 |
| 386 | TRP | 415 | GLY | 2.014 | 9.191 | -7.178 | 7.178 |
| 396 | ASN | 408 | TYR | 6.573 | 0.000 | 6.573 | 6.573 |
| 428 | THR | 434 | ARG | 5.634 | 0.000 | 5.634 | 5.634 |
| 341 | PHE | 343 | ILE | 5.362 | 0.000 | 5.362 | 5.362 |
| 104 | ARG | 177 | ALA | 0.713 | 5.961 | -5.248 | 5.248 |
| 209 | TYR | 375 | LEU | 2.099 | 7.253 | -5.154 | 5.154 |
| 131 | ASP | 142 | TYR | 3.820 | 8.890 | -5.070 | 5.070 |
| 303 | HIS | 304 | GLN | 0.000 | 5.048 | -5.048 | 5.048 |
| 392 | THR | 408 | TYR | 5.228 | 0.181 | 5.047 | 5.047 |
| 131 | ASP | 132 | ARG | 0.000 | 5.029 | -5.029 | 5.029 |
| 62 | GLU | 439 | LYS | 5.037 | 0.196 | 4.841 | 4.841 |
| 418 | ASN | 422 | ASN | 5.252 | 0.472 | 4.780 | 4.780 |
| 31 | ARG | 97 | VAL | 4.749 | 0.000 | 4.749 | 4.749 |
| 220 | ARG | 368 | GLU | 4.662 | 0.000 | 4.662 | 4.662 |
| 233 | ARG | 280 | GLU | 4.541 | 0.000 | 4.541 | 4.541 |
| 265 | VAL | 269 | ARG | 0.000 | 4.235 | -4.235 | 4.235 |
| 386 | TRP | 418 | ASN | 6.181 | 2.153 | 4.028 | 4.028 |
| 37 | TYR | 95 | GLU | 0.180 | 4.113 | -3.933 | 3.933 |
| 175 | ASN | 185 | ALA | 3.966 | 0.133 | 3.834 | 3.834 |
| 428 | THR | 429 | PHE | 0.000 | 3.643 | -3.643 | 3.643 |
| 427 | THR | 434 | ARG | 0.000 | 3.602 | -3.602 | 3.602 |
| 5 | ASN | 7 | SER | 3.584 | 0.000 | 3.584 | 3.584 |
| 382 | PHE | 418 | ASN | 0.000 | 3.439 | -3.439 | 3.439 |
| 132 | ARG | 142 | TYR | 0.000 | 3.414 | -3.414 | 3.414 |
| 104 | ARG | 175 | ASN | 0.000 | 3.414 | -3.414 | 3.414 |
| 175 | ASN | 183 | ILE | 3.741 | 0.381 | 3.359 | 3.359 |
| 132 | ARG | 209 | TYR | 3.348 | 0.000 | 3.348 | 3.348 |
| 122 | ILE | 386 | TRP | 3.271 | 0.000 | 3.271 | 3.271 |
| 202 | PHE | 382 | PHE | 3.247 | 0.000 | 3.247 | 3.247 |
| 125 | LEU | 426 | TYR | 3.244 | 0.000 | 3.244 | 3.244 |
| 16 | GLN | 18 | TRP | 3.476 | 0.238 | 3.238 | 3.238 |
| 378 | VAL | 426 | TYR | 3.364 | 0.132 | 3.232 | 3.232 |
| 198 | PHE | 202 | PHE | 3.159 | 0.000 | 3.159 | 3.159 |
| 341 | PHE | 355 | LEU | 0.000 | 3.126 | -3.126 | 3.126 |
| 132 | ARG | 375 | LEU | 0.000 | 3.119 | -3.119 | 3.119 |
| 73 | ILE | 426 | TYR | 0.863 | 3.954 | -3.091 | 3.091 |
| 136 | VAL | 219 | ARG | 2.542 | 5.566 | -3.024 | 3.024 |
| 382 | PHE | 386 | TRP | 2.339 | 5.339 | -2.999 | 2.999 |
| 115 | VAL | 167 | SER | 0.486 | 3.476 | -2.990 | 2.990 |
| 339 | LYS | 342 | GLU | 0.000 | 2.968 | -2.968 | 2.968 |
| 190 | VAL | 393 | HIS | 5.917 | 3.022 | 2.895 | 2.895 |
| 31 | ARG | 34 | TYR | 2.894 | 0.000 | 2.894 | 2.894 |
| 132 | ARG | 426 | TYR | 2.881 | 0.000 | 2.881 | 2.881 |
| 93 | TYR | 101 | LYS | 1.068 | 3.947 | -2.879 | 2.879 |
| 41 | LEU | 413 | TRP | 11.114 | 8.252 | 2.862 | 2.862 |
| 199 | TYR | 394 | ILE | 5.087 | 2.246 | 2.841 | 2.841 |
| 339 | LYS | 340 | ILE | 2.820 | 0.000 | 2.820 | 2.820 |
| 377 | ILE | 429 | PHE | 0.000 | 2.675 | -2.675 | 2.675 |
| 119 | THR | 163 | SER | 1.785 | 4.442 | -2.657 | 2.657 |
| 4 | LEU | 5 | ASN | 0.000 | 2.649 | -2.649 | 2.649 |
| 312 | HIS | 313 | HIS | 5.338 | 7.954 | -2.616 | 2.616 |
| 209 | TYR | 378 | VAL | 2.602 | 0.000 | 2.602 | 2.602 |
| 34 | TYR | 36 | TYR | 0.000 | 2.576 | -2.576 | 2.576 |
| 142 | TYR | 151 | ARG | 3.282 | 5.832 | -2.550 | 2.550 |
| 229 | SER | 233 | ARG | 2.526 | 0.012 | 2.514 | 2.514 |
| 139 | PRO | 219 | ARG | 0.000 | 2.513 | -2.513 | 2.513 |
| 364 | SER | 368 | GLU | 0.085 | 2.591 | -2.505 | 2.505 |
| 137 | ALA | 219 | ARG | 0.000 | 2.503 | -2.503 | 2.503 |
| 367 | LYS | 432 | GLU | 0.000 | 2.468 | -2.468 | 2.468 |
| 88 | MET | 416 | TYR | 0.852 | 3.308 | -2.456 | 2.456 |
| 70 | ASN | 433 | PHE | 3.650 | 1.195 | 2.454 | 2.454 |
| 399 | CYS | 401 | CYS | 1.173 | 3.605 | -2.433 | 2.433 |
| 55 | VAL | 427 | THR | 2.357 | 0.000 | 2.357 | 2.357 |
| 51 | GLY | 423 | PRO | 1.751 | 4.097 | -2.346 | 2.346 |
| 127 | ALA | 155 | MET | 0.386 | 2.726 | -2.340 | 2.340 |
| 142 | TYR | 148 | SER | 2.974 | 0.679 | 2.296 | 2.296 |
| 100 | TRP | 182 | CYS | 6.712 | 4.420 | 2.292 | 2.292 |
| 50 | PHE | 54 | LEU | 0.024 | 2.305 | -2.281 | 2.281 |
| 134 | THR | 151 | ARG | 2.278 | 0.000 | 2.278 | 2.278 |
| 104 | ARG | 176 | ASN | 0.103 | 2.300 | -2.197 | 2.197 |
| 112 | THR | 171 | LEU | 2.986 | 5.176 | -2.190 | 2.190 |
| 31 | ARG | 96 | VAL | 2.189 | 0.000 | 2.189 | 2.189 |
| 426 | TYR | 433 | PHE | 0.000 | 2.184 | -2.184 | 2.184 |
| 307 | LEU | 308 | PRO | 2.150 | 0.000 | 2.150 | 2.150 |
| 76 | LEU | 121 | SER | 1.838 | 3.924 | -2.086 | 2.086 |
| 424 | ILE | 429 | PHE | 2.083 | 0.000 | 2.083 | 2.083 |
| 129 | SER | 209 | TYR | 2.945 | 4.979 | -2.034 | 2.034 |
| 170 | LEU | 189 | PHE | 5.625 | 3.607 | 2.018 | 2.018 |
| 422 | ASN | 426 | TYR | 0.455 | 2.458 | -2.004 | 2.004 |
| 108 | ASP | 175 | ASN | 1.368 | 3.358 | -1.990 | 1.990 |
| 379 | LEU | 383 | ILE | 0.000 | 1.978 | -1.978 | 1.978 |
| 311 | SER | 312 | HIS | 3.217 | 5.187 | -1.970 | 1.970 |
| 389 | PHE | 408 | TYR | 0.050 | 1.987 | -1.937 | 1.937 |
| 351 | THR | 353 | THR | 1.926 | 0.000 | 1.926 | 1.926 |
| 112 | THR | 167 | SER | 4.636 | 2.719 | 1.917 | 1.917 |
| 343 | ILE | 345 | THR | 2.082 | 0.180 | 1.902 | 1.902 |
| 103 | SER | 106 | HIS | 0.731 | 2.621 | -1.889 | 1.889 |
| 80 | ASP | 422 | ASN | 4.894 | 3.031 | 1.863 | 1.863 |
| 52 | ASN | 77 | ALA | 6.146 | 4.291 | 1.855 | 1.855 |
| 90 | TRP | 110 | PHE | 2.485 | 4.326 | -1.841 | 1.841 |
| 396 | ASN | 403 | ILE | 3.518 | 1.709 | 1.810 | 1.810 |
| 17 | ASN | 19 | SER | 1.806 | 0.000 | 1.806 | 1.806 |
| 297 | PRO | 298 | ILE | 0.000 | 1.784 | -1.784 | 1.784 |
| 31 | ARG | 98 | GLY | 1.784 | 0.000 | 1.784 | 1.784 |
| 216 | LEU | 372 | THR | 0.000 | 1.780 | -1.780 | 1.780 |
| 93 | TYR | 99 | GLU | 0.000 | 1.769 | -1.769 | 1.769 |
| 134 | THR | 142 | TYR | 0.407 | 2.140 | -1.733 | 1.733 |
| 69 | THR | 142 | TYR | 2.508 | 0.777 | 1.730 | 1.730 |
| 169 | PRO | 174 | LEU | 5.437 | 3.721 | 1.715 | 1.715 |
| 90 | TRP | 102 | PHE | 4.635 | 2.924 | 1.711 | 1.711 |
| 62 | GLU | 64 | ALA | 0.000 | 1.711 | -1.711 | 1.711 |
| 59 | VAL | 70 | ASN | 0.149 | 1.855 | -1.707 | 1.707 |
| 267 | ARG | 271 | GLU | 0.639 | 2.329 | -1.690 | 1.690 |
| 386 | TRP | 390 | PHE | 1.207 | 2.879 | -1.672 | 1.672 |
| 54 | LEU | 437 | PHE | 5.582 | 7.250 | -1.668 | 1.668 |
| 432 | GLU | 435 | LYS | 5.296 | 3.634 | 1.662 | 1.662 |
| 397 | ILE | 398 | HIS | 0.000 | 1.652 | -1.652 | 1.652 |
| 133 | TYR | 212 | ILE | 3.215 | 4.858 | -1.643 | 1.643 |
| 175 | ASN | 186 | ASN | 1.642 | 0.000 | 1.642 | 1.642 |
| 385 | CYS | 414 | LEU | 5.234 | 6.867 | -1.633 | 1.633 |
| 301 | SER | 302 | HIS | 0.087 | 1.715 | -1.629 | 1.629 |
| 129 | SER | 208 | VAL | 3.966 | 2.347 | 1.620 | 1.620 |
| 68 | THR | 151 | ARG | 0.000 | 1.618 | -1.618 | 1.618 |
| 374 | MET | 429 | PHE | 0.634 | 2.241 | -1.607 | 1.607 |
| 166 | ILE | 193 | SER | 1.569 | 0.000 | 1.569 | 1.569 |
| 184 | ILE | 190 | VAL | 1.112 | 2.670 | -1.558 | 1.558 |
| 57 | MET | 440 | ILE | 0.894 | 2.420 | -1.526 | 1.526 |
| 324 | LYS | 325 | PRO | 1.578 | 0.071 | 1.507 | 1.507 |
| 198 | PHE | 199 | TYR | 2.875 | 4.370 | -1.495 | 1.495 |
| 374 | MET | 378 | VAL | 1.494 | 0.000 | 1.494 | 1.494 |
| 100 | TRP | 102 | PHE | 3.498 | 2.006 | 1.492 | 1.492 |
| 148 | SER | 151 | ARG | 2.710 | 1.219 | 1.492 | 1.492 |
| 37 | TYR | 413 | TRP | 4.509 | 3.018 | 1.491 | 1.491 |
| 248 | GLU | 251 | LYS | 0.000 | 1.488 | -1.488 | 1.488 |
| 192 | TYR | 196 | VAL | 0.000 | 1.488 | -1.488 | 1.488 |
| 198 | PHE | 382 | PHE | 0.895 | 2.382 | -1.486 | 1.486 |
| 55 | VAL | 437 | PHE | 1.623 | 3.104 | -1.481 | 1.481 |
| 95 | GLU | 409 | SER | 3.262 | 4.744 | -1.481 | 1.481 |
| 120 | ALA | 163 | SER | 2.796 | 4.268 | -1.472 | 1.472 |
| 80 | ASP | 121 | SER | 1.379 | 2.829 | -1.450 | 1.450 |
| 122 | ILE | 382 | PHE | 1.133 | 2.570 | -1.437 | 1.437 |
| 304 | GLN | 305 | LEU | 0.000 | 1.431 | -1.431 | 1.431 |
| 232 | PHE | 236 | LEU | 2.343 | 0.916 | 1.427 | 1.427 |
| 82 | LEU | 117 | MET | 2.394 | 3.821 | -1.427 | 1.427 |
| 174 | LEU | 189 | PHE | 0.000 | 1.426 | -1.426 | 1.426 |
| 52 | ASN | 80 | ASP | 3.852 | 2.427 | 1.425 | 1.425 |
| 136 | VAL | 216 | LEU | 0.000 | 1.402 | -1.402 | 1.402 |
| 119 | THR | 197 | SER | 4.567 | 3.174 | 1.393 | 1.393 |
| 164 | PHE | 168 | CYS | 0.382 | 1.754 | -1.373 | 1.373 |
| 305 | LEU | 306 | THR | 0.563 | 1.934 | -1.371 | 1.371 |
| 94 | LEU | 100 | TRP | 1.283 | 2.641 | -1.358 | 1.358 |
| 191 | VAL | 398 | HIS | 0.000 | 1.356 | -1.356 | 1.356 |
| 128 | ILE | 132 | ARG | 1.702 | 0.349 | 1.353 | 1.353 |
| 213 | TYR | 217 | ARG | 1.608 | 2.956 | -1.348 | 1.348 |
| 141 | LEU | 281 | MET | 0.000 | 1.348 | -1.348 | 1.348 |
| 310 | PRO | 311 | SER | 0.111 | 1.458 | -1.347 | 1.347 |
| 94 | LEU | 99 | GLU | 1.855 | 0.508 | 1.347 | 1.347 |
| 166 | ILE | 189 | PHE | 1.648 | 0.332 | 1.316 | 1.316 |
| 128 | ILE | 426 | TYR | 1.308 | 0.000 | 1.308 | 1.308 |
| 20 | ARG | 21 | PRO | 0.584 | 1.888 | -1.303 | 1.303 |
| 116 | MET | 167 | SER | 3.672 | 4.970 | -1.299 | 1.299 |
| 366 | GLN | 370 | LYS | 1.297 | 0.000 | 1.297 | 1.297 |
| 75 | SER | 124 | ASN | 7.124 | 8.420 | -1.296 | 1.296 |
| 246 | HIS | 247 | PRO | 1.131 | 2.426 | -1.296 | 1.296 |
| 213 | TYR | 372 | THR | 1.277 | 0.000 | 1.277 | 1.277 |
| 129 | SER | 205 | THR | 2.401 | 1.136 | 1.265 | 1.265 |
| 423 | PRO | 428 | THR | 1.260 | 0.000 | 1.260 | 1.260 |
| 337 | ILE | 339 | LYS | 1.247 | 0.000 | 1.247 | 1.247 |
| 243 | ASN | 245 | THR | 0.000 | 1.235 | -1.235 | 1.235 |
| 296 | SER | 298 | ILE | 1.223 | 0.000 | 1.223 | 1.223 |
| 174 | LEU | 186 | ASN | 2.962 | 1.751 | 1.211 | 1.211 |
| 132 | ARG | 135 | ALA | 0.000 | 1.210 | -1.210 | 1.210 |
| 392 | THR | 403 | ILE | 0.542 | 1.751 | -1.209 | 1.209 |
| 378 | VAL | 425 | ILE | 1.010 | 2.212 | -1.202 | 1.202 |
| 385 | CYS | 418 | ASN | 3.629 | 2.431 | 1.198 | 1.198 |
| 57 | MET | 61 | ARG | 2.474 | 1.276 | 1.198 | 1.198 |
| 80 | ASP | 419 | SER | 10.542 | 9.345 | 1.196 | 1.196 |
| 198 | PHE | 387 | LEU | 3.958 | 2.780 | 1.179 | 1.179 |
| 37 | TYR | 41 | LEU | 4.751 | 3.587 | 1.164 | 1.164 |
| 37 | TYR | 409 | SER | 0.286 | 1.427 | -1.141 | 1.141 |
| 403 | ILE | 408 | TYR | 1.370 | 0.234 | 1.136 | 1.136 |
| 60 | SER | 66 | GLN | 0.825 | 1.949 | -1.124 | 1.124 |
| 239 | PRO | 241 | LYS | 1.120 | 0.000 | 1.120 | 1.120 |
| 181 | GLU | 183 | ILE | 0.527 | 1.647 | -1.119 | 1.119 |
| 55 | VAL | 426 | TYR | 0.000 | 1.115 | -1.115 | 1.115 |
| 54 | LEU | 440 | ILE | 2.077 | 0.972 | 1.105 | 1.105 |
| 114 | ASP | 416 | TYR | 5.147 | 4.052 | 1.095 | 1.095 |
| 330 | HIS | 331 | ALA | 0.000 | 1.094 | -1.094 | 1.094 |
| 59 | VAL | 66 | GLN | 1.345 | 2.436 | -1.091 | 1.091 |
| 88 | MET | 413 | TRP | 1.335 | 0.245 | 1.090 | 1.090 |
| 408 | TYR | 412 | THR | 0.000 | 1.087 | -1.087 | 1.087 |
| 189 | PHE | 193 | SER | 2.583 | 1.498 | 1.085 | 1.085 |
| 126 | CYS | 204 | VAL | 1.065 | 0.000 | 1.065 | 1.065 |
| 325 | PRO | 326 | GLU | 1.058 | 0.000 | 1.058 | 1.058 |
| 68 | THR | 142 | TYR | 1.833 | 2.889 | -1.056 | 1.056 |
| 126 | CYS | 201 | PRO | 1.794 | 2.835 | -1.041 | 1.041 |
| 116 | MET | 164 | PHE | 1.911 | 2.949 | -1.038 | 1.038 |
| 323 | ALA | 324 | LYS | 1.030 | 0.000 | 1.030 | 1.030 |
| 123 | LEU | 162 | LEU | 2.013 | 0.983 | 1.030 | 1.030 |
| 116 | MET | 117 | MET | 2.010 | 0.982 | 1.029 | 1.029 |
| 141 | LEU | 151 | ARG | 1.017 | 0.000 | 1.017 | 1.017 |
| 386 | TRP | 389 | PHE | 0.000 | 1.014 | -1.014 | 1.014 |
| 158 | ILE | 162 | LEU | 0.000 | 1.013 | -1.013 | 1.013 |
| 100 | TRP | 106 | HIS | 3.943 | 2.933 | 1.009 | 1.009 |
| 122 | ILE | 390 | PHE | 1.009 | 0.025 | 0.984 | 0.984 |
| 76 | LEU | 124 | ASN | 4.026 | 5.007 | -0.981 | 0.981 |
| 170 | LEU | 175 | ASN | 0.625 | 1.598 | -0.974 | 0.974 |
| 130 | ILE | 155 | MET | 0.988 | 0.018 | 0.970 | 0.970 |
| 32 | PRO | 34 | TYR | 0.000 | 0.962 | -0.962 | 0.962 |
| 209 | TYR | 376 | ALA | 0.000 | 0.953 | -0.953 | 0.953 |
| 7 | SER | 8 | TRP | 0.953 | 0.000 | 0.953 | 0.953 |
| 316 | HIS | 317 | SER | 2.383 | 1.440 | 0.943 | 0.943 |
| 141 | LEU | 148 | SER | 0.935 | 0.000 | 0.935 | 0.935 |
| 136 | VAL | 215 | VAL | 1.236 | 2.171 | -0.935 | 0.935 |
| 162 | LEU | 166 | ILE | 1.059 | 0.127 | 0.932 | 0.932 |
| 138 | MET | 141 | LEU | 1.623 | 0.692 | 0.931 | 0.931 |
| 177 | ALA | 185 | ALA | 0.735 | 1.665 | -0.930 | 0.930 |
| 206 | LEU | 379 | LEU | 0.966 | 0.036 | 0.930 | 0.930 |
| 199 | TYR | 391 | ILE | 2.549 | 1.624 | 0.924 | 0.924 |
| 309 | ASP | 310 | PRO | 3.878 | 2.956 | 0.922 | 0.922 |
| 116 | MET | 160 | TRP | 0.921 | 0.000 | 0.921 | 0.921 |
| 176 | ASN | 186 | ASN | 0.920 | 0.000 | 0.920 | 0.920 |
| 175 | ASN | 177 | ALA | 0.918 | 0.000 | 0.918 | 0.918 |
| 429 | PHE | 434 | ARG | 0.918 | 0.000 | 0.918 | 0.918 |
| 125 | LEU | 378 | VAL | 0.000 | 0.906 | -0.906 | 0.906 |
| 87 | VAL | 110 | PHE | 1.753 | 2.650 | -0.897 | 0.897 |
| 433 | PHE | 437 | PHE | 1.755 | 0.859 | 0.897 | 0.897 |
| 430 | ASN | 433 | PHE | 2.399 | 3.293 | -0.893 | 0.893 |
| 393 | HIS | 408 | TYR | 4.454 | 3.564 | 0.891 | 0.891 |
| 315 | LEU | 316 | HIS | 3.753 | 4.642 | -0.889 | 0.889 |
| 202 | PHE | 383 | ILE | 1.201 | 2.084 | -0.883 | 0.883 |
| 279 | LEU | 282 | GLU | 0.179 | 1.060 | -0.881 | 0.881 |
| 49 | VAL | 81 | LEU | 1.720 | 2.599 | -0.879 | 0.879 |
| 190 | VAL | 397 | ILE | 1.375 | 2.249 | -0.874 | 0.874 |
| 194 | SER | 394 | ILE | 0.000 | 0.870 | -0.870 | 0.870 |
| 44 | LEU | 88 | MET | 0.863 | 0.000 | 0.863 | 0.863 |
| 412 | THR | 416 | TYR | 2.184 | 1.330 | 0.855 | 0.855 |
| 263 | PHE | 268 | ARG | 0.000 | 0.850 | -0.850 | 0.850 |
| 138 | MET | 281 | MET | 0.000 | 0.847 | -0.847 | 0.847 |
| 263 | PHE | 265 | VAL | 0.000 | 0.843 | -0.843 | 0.843 |
| 384 | ILE | 414 | LEU | 1.819 | 0.977 | 0.842 | 0.842 |
| 352 | ARG | 354 | SER | 0.000 | 0.841 | -0.841 | 0.841 |
| 318 | THR | 319 | PRO | 3.744 | 2.913 | 0.831 | 0.831 |
| 58 | ALA | 433 | PHE | 0.117 | 0.946 | -0.829 | 0.829 |
| 425 | ILE | 426 | TYR | 0.879 | 0.052 | 0.827 | 0.827 |
| 275 | ARG | 278 | GLU | 0.106 | 0.930 | -0.825 | 0.825 |
| 95 | GLU | 413 | TRP | 4.015 | 4.838 | -0.824 | 0.824 |
| 403 | ILE | 407 | LEU | 1.028 | 0.206 | 0.823 | 0.823 |
| 170 | LEU | 184 | ILE | 0.000 | 0.811 | -0.811 | 0.811 |
| 111 | VAL | 175 | ASN | 0.807 | 0.000 | 0.807 | 0.807 |
| 357 | THR | 361 | ARG | 0.807 | 0.000 | 0.807 | 0.807 |
| 212 | ILE | 375 | LEU | 0.782 | 0.000 | 0.782 | 0.782 |
| 83 | VAL | 88 | MET | 4.557 | 5.338 | -0.781 | 0.781 |
| 396 | ASN | 401 | CYS | 0.779 | 0.000 | 0.779 | 0.779 |
| 75 | SER | 156 | ILE | 1.827 | 2.606 | -0.779 | 0.779 |
| 61 | ARG | 440 | ILE | 0.306 | 1.080 | -0.774 | 0.774 |
| 45 | ILE | 84 | ALA | 1.014 | 1.783 | -0.769 | 0.769 |
| 125 | LEU | 422 | ASN | 0.766 | 0.000 | 0.766 | 0.766 |
| 189 | PHE | 192 | TYR | 0.000 | 0.765 | -0.765 | 0.765 |
| 374 | MET | 426 | TYR | 0.000 | 0.761 | -0.761 | 0.761 |
| 123 | LEU | 163 | SER | 0.592 | 1.350 | -0.758 | 0.758 |
| 413 | TRP | 416 | TYR | 1.097 | 1.853 | -0.756 | 0.756 |
| 230 | ARG | 361 | ARG | 0.755 | 0.000 | 0.755 | 0.755 |
| 54 | LEU | 441 | LEU | 0.000 | 0.755 | -0.755 | 0.755 |
| 125 | LEU | 382 | PHE | 1.514 | 2.260 | -0.747 | 0.747 |
| 116 | MET | 163 | SER | 4.362 | 3.618 | 0.744 | 0.744 |
| 385 | CYS | 415 | GLY | 2.088 | 2.832 | -0.743 | 0.743 |
| 128 | ILE | 375 | LEU | 0.000 | 0.743 | -0.743 | 0.743 |
| 99 | GLU | 180 | ASN | 0.900 | 0.158 | 0.742 | 0.742 |
| 151 | ARG | 155 | MET | 1.846 | 1.106 | 0.740 | 0.740 |
| 244 | CYS | 253 | CYS | 0.000 | 0.734 | -0.734 | 0.734 |
| 363 | LEU | 367 | LYS | 0.731 | 0.000 | 0.731 | 0.731 |
| 224 | ASN | 365 | GLN | 0.725 | 0.000 | 0.725 | 0.725 |
| 72 | LEU | 128 | ILE | 2.395 | 3.114 | -0.720 | 0.720 |
| 135 | ALA | 142 | TYR | 7.131 | 7.846 | -0.714 | 0.714 |
| 108 | ASP | 171 | LEU | 0.000 | 0.707 | -0.707 | 0.707 |
| 246 | HIS | 248 | GLU | 0.000 | 0.702 | -0.702 | 0.702 |
| 263 | PHE | 264 | PRO | 1.977 | 1.277 | 0.700 | 0.700 |
| 51 | GLY | 437 | PHE | 0.000 | 0.699 | -0.699 | 0.699 |
| 395 | LEU | 399 | CYS | 0.698 | 0.000 | 0.698 | 0.698 |
| 383 | ILE | 388 | PRO | 1.208 | 0.524 | 0.684 | 0.684 |
| 141 | LEU | 147 | SER | 0.683 | 0.000 | 0.683 | 0.683 |
| 94 | LEU | 110 | PHE | 0.000 | 0.681 | -0.681 | 0.681 |
| 217 | ARG | 221 | LYS | 0.676 | 0.000 | 0.676 | 0.676 |
| 72 | LEU | 131 | ASP | 1.500 | 0.825 | 0.675 | 0.675 |
| 166 | ILE | 197 | SER | 1.682 | 1.017 | 0.665 | 0.665 |
| 108 | ASP | 170 | LEU | 1.142 | 0.478 | 0.664 | 0.664 |
| 213 | TYR | 375 | LEU | 0.659 | 0.000 | 0.659 | 0.659 |
| 205 | THR | 379 | LEU | 0.280 | 0.937 | -0.658 | 0.658 |
| 73 | ILE | 427 | THR | 0.655 | 0.000 | 0.655 | 0.655 |
| 209 | TYR | 379 | LEU | 3.667 | 3.019 | 0.649 | 0.649 |
| 300 | PRO | 301 | SER | 0.000 | 0.645 | -0.645 | 0.645 |
| 175 | ASN | 184 | ILE | 3.855 | 3.217 | 0.638 | 0.638 |
| 76 | LEU | 422 | ASN | 2.521 | 1.884 | 0.637 | 0.637 |
| 274 | ARG | 278 | GLU | 3.944 | 4.579 | -0.635 | 0.635 |
| 55 | VAL | 73 | ILE | 0.327 | 0.959 | -0.632 | 0.632 |
| 428 | THR | 437 | PHE | 0.626 | 0.000 | 0.626 | 0.626 |
| 288 | SER | 289 | PRO | 0.000 | 0.626 | -0.626 | 0.626 |
| 93 | TYR | 102 | PHE | 4.818 | 5.444 | -0.625 | 0.625 |
| 246 | HIS | 249 | ASP | 0.480 | 1.100 | -0.620 | 0.620 |
| 407 | LEU | 411 | PHE | 3.900 | 3.285 | 0.615 | 0.615 |
| 35 | ASN | 38 | ALA | 0.000 | 0.601 | -0.601 | 0.601 |
| 68 | THR | 149 | LYS | 0.599 | 0.000 | 0.599 | 0.599 |
| 404 | PRO | 407 | LEU | 0.000 | 0.597 | -0.597 | 0.597 |
| 83 | VAL | 416 | TYR | 0.768 | 1.363 | -0.595 | 0.595 |
| 389 | PHE | 393 | HIS | 0.000 | 0.591 | -0.591 | 0.591 |
| 177 | ALA | 183 | ILE | 1.260 | 0.670 | 0.591 | 0.591 |
| 334 | HIS | 335 | PRO | 1.211 | 1.801 | -0.590 | 0.590 |
| 68 | THR | 131 | ASP | 0.146 | 0.732 | -0.585 | 0.585 |
| 427 | THR | 437 | PHE | 2.798 | 3.374 | -0.577 | 0.577 |
| 93 | TYR | 100 | TRP | 0.000 | 0.575 | -0.575 | 0.575 |
| 132 | ARG | 212 | ILE | 1.174 | 0.600 | 0.574 | 0.574 |
| 56 | CYS | 74 | VAL | 0.233 | 0.805 | -0.572 | 0.572 |
| 392 | THR | 407 | LEU | 0.570 | 0.000 | 0.570 | 0.570 |
| 220 | ARG | 224 | ASN | 0.570 | 0.000 | 0.570 | 0.570 |
| 126 | CYS | 205 | THR | 2.538 | 3.106 | -0.568 | 0.568 |
| 100 | TRP | 107 | CYS | 6.470 | 5.908 | 0.561 | 0.561 |
| 112 | THR | 170 | LEU | 2.708 | 3.269 | -0.561 | 0.561 |
| 130 | ILE | 208 | VAL | 0.414 | 0.975 | -0.561 | 0.561 |
| 104 | ARG | 108 | ASP | 1.149 | 1.709 | -0.559 | 0.559 |
| 198 | PHE | 386 | TRP | 2.770 | 2.212 | 0.558 | 0.558 |
| 216 | LEU | 375 | LEU | 0.558 | 0.000 | 0.558 | 0.558 |
| 306 | THR | 307 | LEU | 0.556 | 0.000 | 0.556 | 0.556 |
| 104 | ARG | 173 | GLY | 0.553 | 0.000 | 0.553 | 0.553 |
| 196 | VAL | 201 | PRO | 2.172 | 2.722 | -0.549 | 0.549 |
| 76 | LEU | 125 | LEU | 1.459 | 0.916 | 0.544 | 0.544 |
| 2 | ASP | 3 | PRO | 0.609 | 1.151 | -0.542 | 0.542 |
| 374 | MET | 430 | ASN | 0.000 | 0.538 | -0.538 | 0.538 |
| 18 | TRP | 19 | SER | 0.000 | 0.537 | -0.537 | 0.537 |
| 69 | THR | 131 | ASP | 4.247 | 3.711 | 0.536 | 0.536 |
| 202 | PHE | 206 | LEU | 0.247 | 0.783 | -0.536 | 0.536 |
| 99 | GLU | 101 | LYS | 8.202 | 7.667 | 0.535 | 0.535 |
| 52 | ASN | 419 | SER | 1.726 | 2.260 | -0.534 | 0.534 |
| 59 | VAL | 65 | LEU | 2.255 | 1.721 | 0.534 | 0.534 |
| 68 | THR | 148 | SER | 3.681 | 3.151 | 0.530 | 0.530 |
| 131 | ASP | 155 | MET | 0.374 | 0.894 | -0.520 | 0.520 |
| 139 | PRO | 140 | MET | 0.000 | 0.518 | -0.518 | 0.518 |
| 209 | TYR | 426 | TYR | 0.506 | 0.000 | 0.506 | 0.506 |
| 136 | VAL | 212 | ILE | 0.230 | 0.729 | -0.500 | 0.500 |
| 79 | ALA | 117 | MET | 0.253 | 0.751 | -0.498 | 0.498 |
| 378 | VAL | 422 | ASN | 0.000 | 0.492 | -0.492 | 0.492 |
| 115 | VAL | 184 | ILE | 0.491 | 0.000 | 0.491 | 0.491 |
| 194 | SER | 390 | PHE | 2.036 | 1.548 | 0.488 | 0.488 |
| 215 | VAL | 219 | ARG | 1.492 | 1.005 | 0.487 | 0.487 |
| 191 | VAL | 397 | ILE | 0.781 | 0.296 | 0.485 | 0.485 |
| 326 | GLU | 327 | LYS | 0.485 | 0.000 | 0.485 | 0.485 |
| 389 | PHE | 411 | PHE | 3.964 | 3.485 | 0.478 | 0.478 |
| 87 | VAL | 114 | ASP | 4.608 | 4.132 | 0.476 | 0.476 |
| 35 | ASN | 96 | VAL | 0.000 | 0.471 | -0.471 | 0.471 |
| 45 | ILE | 89 | PRO | 0.789 | 0.321 | 0.469 | 0.469 |
| 52 | ASN | 81 | LEU | 2.554 | 2.086 | 0.468 | 0.468 |
| 48 | ILE | 419 | SER | 3.060 | 2.596 | 0.464 | 0.464 |
| 83 | VAL | 87 | VAL | 0.037 | 0.500 | -0.462 | 0.462 |
| 31 | ARG | 32 | PRO | 0.021 | 0.484 | -0.462 | 0.462 |
| 118 | CYS | 416 | TYR | 0.678 | 0.216 | 0.462 | 0.462 |
| 160 | TRP | 163 | SER | 0.459 | 0.000 | 0.459 | 0.459 |
| 212 | ILE | 372 | THR | 0.000 | 0.456 | -0.456 | 0.456 |
| 44 | LEU | 48 | ILE | 0.885 | 1.339 | -0.455 | 0.455 |
| 72 | LEU | 124 | ASN | 0.338 | 0.789 | -0.452 | 0.452 |
| 268 | ARG | 271 | GLU | 0.000 | 0.451 | -0.451 | 0.451 |
| 137 | ALA | 215 | VAL | 0.000 | 0.451 | -0.451 | 0.451 |
| 83 | VAL | 419 | SER | 0.450 | 0.000 | 0.450 | 0.450 |
| 118 | CYS | 386 | TRP | 2.232 | 1.782 | 0.450 | 0.450 |
| 76 | LEU | 426 | TYR | 0.538 | 0.988 | -0.450 | 0.450 |
| 126 | CYS | 130 | ILE | 0.445 | 0.000 | 0.445 | 0.445 |
| 87 | VAL | 113 | LEU | 1.022 | 1.467 | -0.444 | 0.444 |
| 438 | LEU | 442 | HIS | 0.000 | 0.444 | -0.444 | 0.444 |
| 386 | TRP | 416 | TYR | 0.000 | 0.439 | -0.439 | 0.439 |
| 55 | VAL | 77 | ALA | 0.493 | 0.927 | -0.434 | 0.434 |
| 73 | ILE | 433 | PHE | 0.009 | 0.443 | -0.434 | 0.434 |
| 55 | VAL | 433 | PHE | 0.256 | 0.688 | -0.432 | 0.432 |
| 387 | LEU | 391 | ILE | 1.522 | 1.952 | -0.430 | 0.430 |
| 132 | ARG | 378 | VAL | 0.424 | 0.000 | 0.424 | 0.424 |
| 113 | LEU | 116 | MET | 0.000 | 0.419 | -0.419 | 0.419 |
| 50 | PHE | 441 | LEU | 0.294 | 0.712 | -0.417 | 0.417 |
| 134 | THR | 138 | MET | 0.312 | 0.726 | -0.414 | 0.414 |
| 199 | TYR | 390 | PHE | 4.392 | 3.978 | 0.413 | 0.413 |
| 129 | SER | 130 | ILE | 0.407 | 0.000 | 0.407 | 0.407 |
| 91 | VAL | 413 | TRP | 2.714 | 3.121 | -0.407 | 0.407 |
| 340 | ILE | 342 | GLU | 0.403 | 0.000 | 0.403 | 0.403 |
| 247 | PRO | 248 | GLU | 0.000 | 0.403 | -0.403 | 0.403 |
| 31 | ARG | 95 | GLU | 0.403 | 0.000 | 0.403 | 0.403 |
| 54 | LEU | 57 | MET | 0.000 | 0.396 | -0.396 | 0.396 |
| 374 | MET | 377 | ILE | 0.396 | 0.000 | 0.396 | 0.396 |
| 125 | LEU | 418 | ASN | 0.394 | 0.000 | 0.394 | 0.394 |
| 79 | ALA | 121 | SER | 2.133 | 2.526 | -0.394 | 0.394 |
| 49 | VAL | 85 | THR | 0.000 | 0.382 | -0.382 | 0.382 |
| 111 | VAL | 170 | LEU | 1.817 | 1.436 | 0.381 | 0.381 |
| 34 | TYR | 95 | GLU | 0.380 | 0.000 | 0.380 | 0.380 |
| 115 | VAL | 170 | LEU | 1.378 | 0.998 | 0.380 | 0.380 |
| 79 | ALA | 120 | ALA | 0.284 | 0.662 | -0.378 | 0.378 |
| 133 | TYR | 137 | ALA | 1.884 | 1.510 | 0.374 | 0.374 |
| 184 | ILE | 189 | PHE | 0.111 | 0.485 | -0.374 | 0.374 |
| 403 | ILE | 404 | PRO | 1.078 | 0.705 | 0.373 | 0.373 |
| 427 | THR | 428 | THR | 0.560 | 0.188 | 0.372 | 0.372 |
| 62 | GLU | 65 | LEU | 1.345 | 1.716 | -0.371 | 0.371 |
| 115 | VAL | 197 | SER | 0.000 | 0.369 | -0.369 | 0.369 |
| 97 | VAL | 101 | LYS | 0.432 | 0.797 | -0.365 | 0.365 |
| 84 | ALA | 89 | PRO | 1.910 | 1.546 | 0.364 | 0.364 |
| 100 | TRP | 180 | ASN | 3.766 | 3.402 | 0.364 | 0.364 |
| 115 | VAL | 193 | SER | 0.477 | 0.839 | -0.361 | 0.361 |
| 206 | LEU | 210 | ILE | 0.984 | 0.624 | 0.359 | 0.359 |
| 373 | GLN | 429 | PHE | 0.000 | 0.359 | -0.359 | 0.359 |
| 424 | ILE | 428 | THR | 0.664 | 0.306 | 0.358 | 0.358 |
| 100 | TRP | 110 | PHE | 1.365 | 1.013 | 0.353 | 0.353 |
| 44 | LEU | 417 | VAL | 1.262 | 0.911 | 0.351 | 0.351 |
| 430 | ASN | 432 | GLU | 0.866 | 1.216 | -0.350 | 0.350 |
| 79 | ALA | 160 | TRP | 2.057 | 2.403 | -0.347 | 0.347 |
| 107 | CYS | 175 | ASN | 0.346 | 0.000 | 0.346 | 0.346 |
| 226 | LYS | 230 | ARG | 0.000 | 0.341 | -0.341 | 0.341 |
| 133 | TYR | 208 | VAL | 1.387 | 1.049 | 0.339 | 0.339 |
| 335 | PRO | 336 | LYS | 0.645 | 0.978 | -0.333 | 0.333 |
| 52 | ASN | 423 | PRO | 3.698 | 4.031 | -0.332 | 0.332 |
| 48 | ILE | 80 | ASP | 1.161 | 0.833 | 0.329 | 0.329 |
| 124 | ASN | 159 | VAL | 3.440 | 3.759 | -0.319 | 0.319 |
| 317 | SER | 318 | THR | 0.319 | 0.000 | 0.319 | 0.319 |
| 71 | TYR | 152 | VAL | 0.914 | 0.596 | 0.318 | 0.318 |
| 108 | ASP | 173 | GLY | 0.315 | 0.000 | 0.315 | 0.315 |
| 60 | SER | 61 | ARG | 0.000 | 0.313 | -0.313 | 0.313 |
| 110 | PHE | 111 | VAL | 0.490 | 0.800 | -0.310 | 0.310 |
| 308 | PRO | 309 | ASP | 0.306 | 0.000 | 0.306 | 0.306 |
| 389 | PHE | 390 | PHE | 1.778 | 2.080 | -0.302 | 0.302 |
| 62 | GLU | 63 | LYS | 0.000 | 0.302 | -0.302 | 0.302 |
| 204 | VAL | 208 | VAL | 0.366 | 0.065 | 0.301 | 0.301 |
| 110 | PHE | 182 | CYS | 0.609 | 0.904 | -0.295 | 0.295 |
| 107 | CYS | 182 | CYS | 6.670 | 6.964 | -0.295 | 0.295 |
| 226 | LYS | 283 | MET | 0.294 | 0.000 | 0.294 | 0.294 |
| 73 | ILE | 128 | ILE | 0.820 | 1.111 | -0.291 | 0.291 |
| 58 | ALA | 436 | ALA | 0.705 | 0.995 | -0.290 | 0.290 |
| 62 | GLU | 436 | ALA | 0.715 | 0.428 | 0.286 | 0.286 |
| 78 | VAL | 160 | TRP | 0.005 | 0.290 | -0.285 | 0.285 |
| 137 | ALA | 138 | MET | 0.217 | 0.500 | -0.282 | 0.282 |
| 373 | GLN | 377 | ILE | 0.953 | 0.671 | 0.282 | 0.282 |
| 385 | CYS | 386 | TRP | 0.251 | 0.531 | -0.280 | 0.280 |
| 120 | ALA | 160 | TRP | 1.516 | 1.790 | -0.274 | 0.274 |
| 168 | CYS | 172 | PHE | 1.334 | 1.064 | 0.270 | 0.270 |
| 69 | THR | 128 | ILE | 0.000 | 0.270 | -0.270 | 0.270 |
| 63 | LYS | 66 | GLN | 0.335 | 0.604 | -0.269 | 0.269 |
| 365 | GLN | 368 | GLU | 0.000 | 0.268 | -0.268 | 0.268 |
| 294 | ARG | 295 | TYR | 0.266 | 0.000 | 0.266 | 0.266 |
| 78 | VAL | 82 | LEU | 0.280 | 0.546 | -0.266 | 0.266 |
| 194 | SER | 199 | TYR | 4.332 | 4.066 | 0.266 | 0.266 |
| 401 | CYS | 403 | ILE | 0.415 | 0.149 | 0.266 | 0.266 |
| 191 | VAL | 195 | ILE | 0.509 | 0.773 | -0.264 | 0.264 |
| 65 | LEU | 432 | GLU | 1.598 | 1.861 | -0.263 | 0.263 |
| 351 | THR | 354 | SER | 0.261 | 0.000 | 0.261 | 0.261 |
| 52 | ASN | 55 | VAL | 0.000 | 0.261 | -0.261 | 0.261 |
| 93 | TYR | 97 | VAL | 3.385 | 3.644 | -0.260 | 0.260 |
| 35 | ASN | 39 | THR | 0.258 | 0.000 | 0.258 | 0.258 |
| 169 | PRO | 189 | PHE | 1.431 | 1.174 | 0.257 | 0.257 |
| 409 | SER | 413 | TRP | 1.698 | 1.441 | 0.257 | 0.257 |
| 374 | MET | 425 | ILE | 1.696 | 1.439 | 0.256 | 0.256 |
| 179 | GLN | 180 | ASN | 0.268 | 0.523 | -0.255 | 0.255 |
| 67 | THR | 70 | ASN | 4.365 | 4.110 | 0.255 | 0.255 |
| 123 | LEU | 201 | PRO | 0.696 | 0.947 | -0.252 | 0.252 |
| 369 | LYS | 373 | GLN | 0.000 | 0.250 | -0.250 | 0.250 |
| 382 | PHE | 387 | LEU | 0.415 | 0.165 | 0.249 | 0.249 |
| 100 | TRP | 179 | GLN | 0.399 | 0.150 | 0.249 | 0.249 |
| 331 | ALA | 332 | LYS | 0.000 | 0.245 | -0.245 | 0.245 |
| 134 | THR | 139 | PRO | 0.426 | 0.188 | 0.238 | 0.238 |
| 214 | ILE | 218 | ARG | 1.895 | 2.133 | -0.238 | 0.238 |
| 47 | VAL | 420 | ALA | 0.378 | 0.140 | 0.238 | 0.238 |
| 381 | VAL | 385 | CYS | 0.350 | 0.588 | -0.238 | 0.238 |
| 55 | VAL | 423 | PRO | 0.808 | 1.045 | -0.237 | 0.237 |
| 87 | VAL | 416 | TYR | 0.936 | 1.173 | -0.237 | 0.237 |
| 227 | ARG | 365 | GLN | 0.232 | 0.000 | 0.232 | 0.232 |
| 58 | ALA | 437 | PHE | 0.961 | 1.190 | -0.229 | 0.229 |
| 321 | SER | 322 | PRO | 2.142 | 1.919 | 0.224 | 0.224 |
| 133 | TYR | 215 | VAL | 0.000 | 0.223 | -0.223 | 0.223 |
| 130 | ILE | 204 | VAL | 0.220 | 0.000 | 0.220 | 0.220 |
| 209 | TYR | 212 | ILE | 0.769 | 0.549 | 0.220 | 0.220 |
| 83 | VAL | 121 | SER | 0.220 | 0.000 | 0.220 | 0.220 |
| 82 | LEU | 86 | LEU | 0.773 | 0.992 | -0.219 | 0.219 |
| 85 | THR | 86 | LEU | 0.753 | 0.971 | -0.218 | 0.218 |
| 320 | ASP | 321 | SER | 0.632 | 0.415 | 0.218 | 0.218 |
| 1 | MET | 2 | ASP | 0.000 | 0.217 | -0.217 | 0.217 |
| 133 | TYR | 211 | LYS | 2.155 | 2.372 | -0.216 | 0.216 |
| 122 | ILE | 198 | PHE | 0.456 | 0.669 | -0.213 | 0.213 |
| 159 | VAL | 163 | SER | 0.000 | 0.211 | -0.211 | 0.211 |
| 425 | ILE | 430 | ASN | 0.000 | 0.210 | -0.210 | 0.210 |
| 147 | SER | 151 | ARG | 0.000 | 0.209 | -0.209 | 0.209 |
| 68 | THR | 69 | THR | 0.177 | 0.381 | -0.203 | 0.203 |
| 53 | VAL | 57 | MET | 0.870 | 0.667 | 0.203 | 0.203 |
| 374 | MET | 375 | LEU | 0.000 | 0.203 | -0.203 | 0.203 |
| 271 | GLU | 275 | ARG | 0.000 | 0.202 | -0.202 | 0.202 |
| 48 | ILE | 420 | ALA | 2.832 | 2.631 | 0.201 | 0.201 |
| 87 | VAL | 91 | VAL | 0.459 | 0.258 | 0.201 | 0.201 |
| 49 | VAL | 53 | VAL | 0.435 | 0.236 | 0.199 | 0.199 |
| 102 | PHE | 106 | HIS | 0.968 | 0.771 | 0.197 | 0.197 |
| 122 | ILE | 197 | SER | 2.781 | 2.975 | -0.194 | 0.194 |
| 370 | LYS | 429 | PHE | 0.000 | 0.194 | -0.194 | 0.194 |
| 93 | TYR | 94 | LEU | 0.000 | 0.193 | -0.193 | 0.193 |
| 82 | LEU | 160 | TRP | 0.835 | 0.644 | 0.192 | 0.192 |
| 58 | ALA | 440 | ILE | 1.876 | 1.685 | 0.191 | 0.191 |
| 395 | LEU | 403 | ILE | 0.526 | 0.335 | 0.191 | 0.191 |
| 216 | LEU | 371 | ALA | 0.190 | 0.000 | 0.190 | 0.190 |
| 111 | VAL | 184 | ILE | 1.226 | 1.416 | -0.190 | 0.190 |
| 129 | SER | 212 | ILE | 0.404 | 0.594 | -0.190 | 0.190 |
| 114 | ASP | 118 | CYS | 1.295 | 1.483 | -0.188 | 0.188 |
| 252 | LEU | 256 | ILE | 0.285 | 0.099 | 0.187 | 0.187 |
| 123 | LEU | 126 | CYS | 0.000 | 0.186 | -0.186 | 0.186 |
| 162 | LEU | 196 | VAL | 0.186 | 0.000 | 0.186 | 0.186 |
| 44 | LEU | 413 | TRP | 0.603 | 0.788 | -0.184 | 0.184 |
| 340 | ILE | 341 | PHE | 0.000 | 0.182 | -0.182 | 0.182 |
| 65 | LEU | 70 | ASN | 6.309 | 6.491 | -0.182 | 0.182 |
| 123 | LEU | 166 | ILE | 0.000 | 0.182 | -0.182 | 0.182 |
| 91 | VAL | 95 | GLU | 0.000 | 0.181 | -0.181 | 0.181 |
| 346 | MET | 347 | PRO | 0.565 | 0.743 | -0.177 | 0.177 |
| 348 | ASN | 350 | LYS | 0.000 | 0.175 | -0.175 | 0.175 |
| 385 | CYS | 411 | PHE | 0.173 | 0.345 | -0.172 | 0.172 |
| 79 | ALA | 124 | ASN | 0.416 | 0.247 | 0.169 | 0.169 |
| 131 | ASP | 151 | ARG | 2.881 | 2.713 | 0.169 | 0.169 |
| 38 | ALA | 92 | VAL | 0.344 | 0.176 | 0.168 | 0.168 |
| 91 | VAL | 416 | TYR | 2.153 | 2.320 | -0.167 | 0.167 |
| 100 | TRP | 181 | GLU | 0.166 | 0.000 | 0.166 | 0.166 |
| 69 | THR | 73 | ILE | 0.163 | 0.000 | 0.163 | 0.163 |
| 194 | SER | 393 | HIS | 0.522 | 0.683 | -0.161 | 0.161 |
| 250 | MET | 254 | THR | 0.000 | 0.161 | -0.161 | 0.161 |
| 58 | ALA | 65 | LEU | 2.232 | 2.393 | -0.161 | 0.161 |
| 74 | VAL | 78 | VAL | 0.304 | 0.144 | 0.160 | 0.160 |
| 92 | VAL | 96 | VAL | 0.052 | 0.209 | -0.157 | 0.157 |
| 97 | VAL | 99 | GLU | 0.669 | 0.514 | 0.155 | 0.155 |
| 434 | ARG | 438 | LEU | 0.000 | 0.154 | -0.154 | 0.154 |
| 205 | THR | 209 | TYR | 1.556 | 1.403 | 0.154 | 0.154 |
| 72 | LEU | 152 | VAL | 0.560 | 0.713 | -0.153 | 0.153 |
| 193 | SER | 198 | PHE | 0.058 | 0.210 | -0.152 | 0.152 |
| 113 | LEU | 117 | MET | 0.336 | 0.488 | -0.152 | 0.152 |
| 84 | ALA | 88 | MET | 0.075 | 0.227 | -0.152 | 0.152 |
| 441 | LEU | 442 | HIS | 0.000 | 0.152 | -0.152 | 0.152 |
| 32 | PRO | 33 | HIS | 0.151 | 0.000 | 0.151 | 0.151 |
| 83 | VAL | 118 | CYS | 0.188 | 0.340 | -0.151 | 0.151 |
| 48 | ILE | 52 | ASN | 0.958 | 0.807 | 0.151 | 0.151 |
| 68 | THR | 152 | VAL | 3.884 | 4.034 | -0.150 | 0.150 |
| 76 | LEU | 128 | ILE | 0.539 | 0.390 | 0.149 | 0.149 |
| 411 | PHE | 414 | LEU | 0.373 | 0.225 | 0.148 | 0.148 |
| 423 | PRO | 437 | PHE | 0.000 | 0.147 | -0.147 | 0.147 |
| 65 | LEU | 433 | PHE | 3.923 | 3.778 | 0.145 | 0.145 |
| 144 | THR | 146 | TYR | 0.000 | 0.144 | -0.144 | 0.144 |
| 140 | MET | 277 | GLN | 0.000 | 0.144 | -0.144 | 0.144 |
| 193 | SER | 197 | SER | 0.669 | 0.812 | -0.143 | 0.143 |
| 379 | LEU | 382 | PHE | 0.000 | 0.142 | -0.142 | 0.142 |
| 69 | THR | 70 | ASN | 0.032 | 0.173 | -0.140 | 0.140 |
| 93 | TYR | 98 | GLY | 0.008 | 0.146 | -0.138 | 0.138 |
| 107 | CYS | 183 | ILE | 0.000 | 0.137 | -0.137 | 0.137 |
| 238 | ALA | 239 | PRO | 0.328 | 0.464 | -0.136 | 0.136 |
| 82 | LEU | 87 | VAL | 0.843 | 0.978 | -0.135 | 0.135 |
| 90 | TRP | 100 | TRP | 1.656 | 1.789 | -0.133 | 0.133 |
| 383 | ILE | 387 | LEU | 0.684 | 0.813 | -0.129 | 0.129 |
| 186 | ASN | 187 | PRO | 1.032 | 0.904 | 0.128 | 0.128 |
| 126 | CYS | 129 | SER | 0.127 | 0.000 | 0.127 | 0.127 |
| 125 | LEU | 205 | THR | 0.111 | 0.235 | -0.124 | 0.124 |
| 195 | ILE | 200 | VAL | 4.298 | 4.176 | 0.122 | 0.122 |
| 66 | GLN | 71 | TYR | 2.908 | 3.029 | -0.121 | 0.121 |
| 298 | ILE | 299 | PRO | 1.180 | 1.300 | -0.119 | 0.119 |
| 392 | THR | 411 | PHE | 2.991 | 2.872 | 0.119 | 0.119 |
| 161 | VAL | 165 | THR | 0.415 | 0.296 | 0.119 | 0.119 |
| 94 | LEU | 182 | CYS | 0.117 | 0.000 | 0.117 | 0.117 |
| 65 | LEU | 430 | ASN | 0.000 | 0.117 | -0.117 | 0.117 |
| 394 | ILE | 398 | HIS | 1.211 | 1.328 | -0.117 | 0.117 |
| 120 | ALA | 159 | VAL | 1.314 | 1.198 | 0.116 | 0.116 |
| 86 | LEU | 113 | LEU | 0.189 | 0.305 | -0.116 | 0.116 |
| 72 | LEU | 155 | MET | 0.707 | 0.822 | -0.115 | 0.115 |
| 299 | PRO | 300 | PRO | 0.580 | 0.466 | 0.113 | 0.113 |
| 256 | ILE | 260 | ASN | 0.113 | 0.000 | 0.113 | 0.113 |
| 164 | PHE | 167 | SER | 0.111 | 0.000 | 0.111 | 0.111 |
| 391 | ILE | 395 | LEU | 1.043 | 0.932 | 0.111 | 0.111 |
| 388 | PRO | 411 | PHE | 6.189 | 6.079 | 0.110 | 0.110 |
| 168 | CYS | 169 | PRO | 0.810 | 0.701 | 0.110 | 0.110 |
| 176 | ASN | 185 | ALA | 1.038 | 1.147 | -0.109 | 0.109 |
| 144 | THR | 147 | SER | 1.626 | 1.517 | 0.108 | 0.108 |
| 115 | VAL | 166 | ILE | 0.107 | 0.000 | 0.107 | 0.107 |
| 43 | LEU | 47 | VAL | 0.001 | 0.108 | -0.107 | 0.107 |
| 80 | ASP | 423 | PRO | 0.106 | 0.000 | 0.106 | 0.106 |
| 210 | ILE | 214 | ILE | 0.719 | 0.614 | 0.105 | 0.105 |
| 127 | ALA | 159 | VAL | 0.444 | 0.549 | -0.105 | 0.105 |
| 381 | VAL | 421 | VAL | 1.037 | 1.142 | -0.105 | 0.105 |
| 266 | ASN | 269 | ARG | 0.104 | 0.000 | 0.104 | 0.104 |
| 42 | THR | 92 | VAL | 0.261 | 0.161 | 0.100 | 0.100 |
| 86 | LEU | 117 | MET | 0.000 | 0.099 | -0.099 | 0.099 |
| 87 | VAL | 117 | MET | 0.099 | 0.000 | 0.099 | 0.099 |
| 208 | VAL | 212 | ILE | 0.418 | 0.320 | 0.098 | 0.098 |
| 83 | VAL | 89 | PRO | 0.025 | 0.123 | -0.098 | 0.098 |
| 53 | VAL | 81 | LEU | 1.534 | 1.630 | -0.097 | 0.097 |
| 75 | SER | 160 | TRP | 2.315 | 2.409 | -0.094 | 0.094 |
| 150 | ARG | 154 | VAL | 0.071 | 0.163 | -0.092 | 0.092 |
| 389 | PHE | 412 | THR | 3.804 | 3.894 | -0.090 | 0.090 |
| 156 | ILE | 160 | TRP | 1.245 | 1.154 | 0.090 | 0.090 |
| 48 | ILE | 88 | MET | 1.504 | 1.417 | 0.086 | 0.086 |
| 122 | ILE | 201 | PRO | 0.976 | 1.061 | -0.086 | 0.086 |
| 289 | PRO | 290 | PRO | 0.312 | 0.397 | -0.085 | 0.085 |
| 6 | LEU | 8 | TRP | 0.000 | 0.085 | -0.085 | 0.085 |
| 280 | GLU | 284 | LEU | 0.084 | 0.000 | 0.084 | 0.084 |
| 109 | ILE | 113 | LEU | 0.737 | 0.821 | -0.083 | 0.083 |
| 45 | ILE | 88 | MET | 2.811 | 2.894 | -0.083 | 0.083 |
| 117 | MET | 160 | TRP | 1.208 | 1.291 | -0.082 | 0.082 |
| 107 | CYS | 111 | VAL | 0.391 | 0.473 | -0.082 | 0.082 |
| 198 | PHE | 390 | PHE | 14.351 | 14.432 | -0.081 | 0.081 |
| 72 | LEU | 127 | ALA | 1.137 | 1.218 | -0.081 | 0.081 |
| 96 | VAL | 97 | VAL | 0.000 | 0.080 | -0.080 | 0.080 |
| 56 | CYS | 81 | LEU | 0.304 | 0.225 | 0.079 | 0.079 |
| 56 | CYS | 78 | VAL | 0.269 | 0.191 | 0.078 | 0.078 |
| 109 | ILE | 171 | LEU | 0.394 | 0.471 | -0.077 | 0.077 |
| 431 | ILE | 435 | LYS | 0.639 | 0.563 | 0.076 | 0.076 |
| 387 | LEU | 388 | PRO | 0.813 | 0.737 | 0.076 | 0.076 |
| 48 | ILE | 84 | ALA | 1.091 | 1.016 | 0.075 | 0.075 |
| 133 | TYR | 138 | MET | 0.204 | 0.130 | 0.074 | 0.074 |
| 111 | VAL | 182 | CYS | 0.534 | 0.607 | -0.073 | 0.073 |
| 52 | ASN | 422 | ASN | 0.000 | 0.068 | -0.068 | 0.068 |
| 138 | MET | 219 | ARG | 0.000 | 0.066 | -0.066 | 0.066 |
| 67 | THR | 69 | THR | 0.000 | 0.065 | -0.065 | 0.065 |
| 45 | ILE | 49 | VAL | 0.215 | 0.150 | 0.065 | 0.065 |
| 203 | ILE | 207 | LEU | 0.743 | 0.678 | 0.065 | 0.065 |
| 92 | VAL | 413 | TRP | 1.381 | 1.316 | 0.065 | 0.065 |
| 431 | ILE | 432 | GLU | 0.267 | 0.202 | 0.065 | 0.065 |
| 124 | ASN | 160 | TRP | 0.141 | 0.076 | 0.064 | 0.064 |
| 381 | VAL | 425 | ILE | 0.454 | 0.518 | -0.064 | 0.064 |
| 38 | ALA | 96 | VAL | 0.884 | 0.820 | 0.064 | 0.064 |
| 363 | LEU | 366 | GLN | 0.253 | 0.194 | 0.060 | 0.060 |
| 119 | THR | 167 | SER | 0.000 | 0.060 | -0.060 | 0.060 |
| 119 | THR | 166 | ILE | 0.594 | 0.653 | -0.060 | 0.060 |
| 125 | LEU | 386 | TRP | 0.058 | 0.000 | 0.058 | 0.058 |
| 70 | ASN | 73 | ILE | 0.597 | 0.539 | 0.058 | 0.058 |
| 48 | ILE | 416 | TYR | 0.632 | 0.690 | -0.058 | 0.058 |
| 71 | TYR | 156 | ILE | 0.731 | 0.788 | -0.057 | 0.057 |
| 105 | ILE | 109 | ILE | 0.508 | 0.565 | -0.056 | 0.056 |
| 88 | MET | 89 | PRO | 0.752 | 0.696 | 0.056 | 0.056 |
| 91 | VAL | 110 | PHE | 1.551 | 1.496 | 0.056 | 0.056 |
| 377 | ILE | 425 | ILE | 0.994 | 0.940 | 0.054 | 0.054 |
| 296 | SER | 297 | PRO | 0.043 | 0.097 | -0.054 | 0.054 |
| 86 | LEU | 87 | VAL | 0.054 | 0.000 | 0.054 | 0.054 |
| 381 | VAL | 418 | ASN | 1.113 | 1.166 | -0.053 | 0.053 |
| 123 | LEU | 159 | VAL | 4.013 | 4.066 | -0.053 | 0.053 |
| 417 | VAL | 421 | VAL | 0.443 | 0.390 | 0.053 | 0.053 |
| 55 | VAL | 74 | VAL | 0.000 | 0.052 | -0.052 | 0.052 |
| 59 | VAL | 71 | TYR | 0.000 | 0.052 | -0.052 | 0.052 |
| 430 | ASN | 431 | ILE | 0.051 | 0.000 | 0.051 | 0.051 |
| 195 | ILE | 196 | VAL | 0.000 | 0.049 | -0.049 | 0.049 |
| 187 | PRO | 397 | ILE | 1.771 | 1.820 | -0.049 | 0.049 |
| 159 | VAL | 160 | TRP | 0.022 | 0.071 | -0.049 | 0.049 |
| 200 | VAL | 201 | PRO | 1.407 | 1.455 | -0.048 | 0.048 |
| 426 | TYR | 427 | THR | 0.046 | 0.000 | 0.046 | 0.046 |
| 114 | ASP | 119 | THR | 0.000 | 0.045 | -0.045 | 0.045 |
| 388 | PRO | 414 | LEU | 0.289 | 0.333 | -0.044 | 0.044 |
| 125 | LEU | 128 | ILE | 0.000 | 0.043 | -0.043 | 0.043 |
| 44 | LEU | 420 | ALA | 0.510 | 0.468 | 0.042 | 0.042 |
| 166 | ILE | 167 | SER | 0.000 | 0.041 | -0.041 | 0.041 |
| 195 | ILE | 199 | TYR | 0.041 | 0.000 | 0.041 | 0.041 |
| 82 | LEU | 85 | THR | 0.118 | 0.078 | 0.040 | 0.040 |
| 168 | CYS | 171 | LEU | 0.000 | 0.040 | -0.040 | 0.040 |
| 183 | ILE | 185 | ALA | 0.040 | 0.000 | 0.040 | 0.040 |
| 200 | VAL | 204 | VAL | 0.013 | 0.053 | -0.040 | 0.040 |
| 128 | ILE | 209 | TYR | 0.037 | 0.000 | 0.037 | 0.037 |
| 57 | MET | 62 | GLU | 0.000 | 0.036 | -0.036 | 0.036 |
| 76 | LEU | 80 | ASP | 1.344 | 1.309 | 0.035 | 0.035 |
| 57 | MET | 60 | SER | 0.000 | 0.035 | -0.035 | 0.035 |
| 166 | ILE | 196 | VAL | 1.872 | 1.838 | 0.034 | 0.034 |
| 72 | LEU | 156 | ILE | 0.888 | 0.854 | 0.033 | 0.033 |
| 83 | VAL | 117 | MET | 2.007 | 2.040 | -0.033 | 0.033 |
| 33 | HIS | 35 | ASN | 0.000 | 0.033 | -0.033 | 0.033 |
| 377 | ILE | 381 | VAL | 0.215 | 0.182 | 0.033 | 0.033 |
| 154 | VAL | 158 | ILE | 0.899 | 0.869 | 0.031 | 0.031 |
| 49 | VAL | 84 | ALA | 0.632 | 0.662 | -0.030 | 0.030 |
| 138 | MET | 139 | PRO | 0.117 | 0.090 | 0.027 | 0.027 |
| 135 | ALA | 219 | ARG | 0.000 | 0.027 | -0.027 | 0.027 |
| 422 | ASN | 423 | PRO | 0.982 | 1.008 | -0.026 | 0.026 |
| 59 | VAL | 433 | PHE | 1.409 | 1.435 | -0.026 | 0.026 |
| 143 | ASN | 148 | SER | 0.025 | 0.000 | 0.025 | 0.025 |
| 202 | PHE | 203 | ILE | 0.159 | 0.134 | 0.025 | 0.025 |
| 41 | LEU | 92 | VAL | 0.853 | 0.877 | -0.024 | 0.024 |
| 89 | PRO | 90 | TRP | 0.023 | 0.000 | 0.023 | 0.023 |
| 302 | HIS | 304 | GLN | 0.000 | 0.023 | -0.023 | 0.023 |
| 41 | LEU | 95 | GLU | 0.310 | 0.332 | -0.022 | 0.022 |
| 195 | ILE | 201 | PRO | 0.314 | 0.336 | -0.022 | 0.022 |
| 103 | SER | 105 | ILE | 0.479 | 0.501 | -0.022 | 0.022 |
| 212 | ILE | 216 | LEU | 0.702 | 0.723 | -0.021 | 0.021 |
| 370 | LYS | 431 | ILE | 0.000 | 0.021 | -0.021 | 0.021 |
| 56 | CYS | 77 | ALA | 0.526 | 0.545 | -0.020 | 0.020 |
| 190 | VAL | 194 | SER | 0.441 | 0.461 | -0.019 | 0.019 |
| 186 | ASN | 189 | PHE | 1.998 | 1.980 | 0.019 | 0.019 |
| 119 | THR | 123 | LEU | 0.986 | 0.968 | 0.018 | 0.018 |
| 111 | VAL | 115 | VAL | 0.025 | 0.040 | -0.015 | 0.015 |
| 425 | ILE | 429 | PHE | 0.469 | 0.454 | 0.015 | 0.015 |
| 419 | SER | 422 | ASN | 0.014 | 0.000 | 0.014 | 0.014 |
| 153 | THR | 157 | SER | 0.130 | 0.143 | -0.013 | 0.013 |
| 199 | TYR | 387 | LEU | 0.000 | 0.012 | -0.012 | 0.012 |
| 120 | ALA | 124 | ASN | 0.148 | 0.137 | 0.011 | 0.011 |
| 282 | GLU | 285 | SER | 0.010 | 0.000 | 0.010 | 0.010 |
| 130 | ILE | 134 | THR | 0.241 | 0.231 | 0.010 | 0.010 |
| 152 | VAL | 156 | ILE | 0.895 | 0.886 | 0.009 | 0.009 |
| 112 | THR | 168 | CYS | 0.000 | 0.009 | -0.009 | 0.009 |
| 45 | ILE | 92 | VAL | 0.564 | 0.556 | 0.008 | 0.008 |
| 421 | VAL | 425 | ILE | 1.071 | 1.063 | 0.008 | 0.008 |
| 404 | PRO | 405 | PRO | 0.430 | 0.436 | -0.006 | 0.006 |
| 382 | PHE | 383 | ILE | 0.000 | 0.006 | -0.006 | 0.006 |
| 354 | SER | 357 | THR | 0.006 | 0.000 | 0.006 | 0.006 |
| 65 | LEU | 436 | ALA | 0.678 | 0.683 | -0.005 | 0.005 |
| 59 | VAL | 74 | VAL | 1.970 | 1.975 | -0.004 | 0.004 |
| 113 | LEU | 118 | CYS | 0.000 | 0.003 | -0.003 | 0.003 |
| 48 | ILE | 81 | LEU | 0.080 | 0.077 | 0.003 | 0.003 |
| 186 | ASN | 188 | ALA | 0.758 | 0.761 | -0.003 | 0.003 |
| 110 | PHE | 114 | ASP | 0.001 | 0.000 | 0.001 | 0.001 |
| 107 | CYS | 112 | THR | 0.000 | 0.001 | -0.001 | 0.001 |
| 115 | VAL | 119 | THR | 0.369 | 0.369 | 0.000 | 0.000 |
RRCS change distribution
-0.06
Mean ΔRRCS
1.58
Std Dev
-0.04
Median
Magnitude classification
16
High (|Δ| ≥ 5.0)
59
Medium (2.2 ≤ |Δ| < 5.0)
624
Low (|Δ| < 2.2)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.21, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar