DRD3
742
Total Contact Pairs
70
Significant Changes
14.20
Max Increase
-8.46
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | GLN260 | ARG323 (6.29x29) | 14.196 | 0.000 | +14.196 | HIGH |
| 2 | THR262 | ILE388 (8.48x48) | 13.738 | 0.000 | +13.738 | HIGH |
| 3 | ARG219 (5.69x69) | VAL320 (6.26x26) | 10.253 | 0.000 | +10.253 | HIGH |
| 4 | THR384 (7.54x54) | PHE390 (8.50x50) | 9.595 | 0.002 | +9.592 | HIGH |
| 5 | GLU297 | SER309 | 0.000 | 8.462 | -8.462 | HIGH |
| 6 | ARG323 (6.29x29) | GLU389 (8.49x49) | 0.000 | 8.282 | -8.282 | HIGH |
| 7 | THR64 (2.39x39) | ARG128 (3.50x50) | 0.000 | 8.247 | -8.247 | HIGH |
| 8 | THR262 | GLU389 (8.49x49) | 8.204 | 0.000 | +8.204 | HIGH |
| 9 | SER295 | LYS311 | 0.000 | 7.814 | -7.814 | HIGH |
| 10 | PHE338 (6.44x44) | TRP342 (6.48x48) | 2.140 | 9.882 | -7.743 | HIGH |
| 11 | ARG299 | SER307 | 0.000 | 7.387 | -7.387 | HIGH |
| 12 | THR63 (2.38x38) | GLY141 (34.56x56) | 7.384 | 0.000 | +7.384 | HIGH |
| 13 | GLU297 | ARG299 | 0.013 | 6.591 | -6.578 | HIGH |
| 14 | ILE388 (8.48x48) | ARG391 (8.51x51) | 6.507 | 0.444 | +6.063 | HIGH |
| 15 | ARG222 (5.72x72) | VAL320 (6.26x26) | 0.000 | 5.812 | -5.812 | HIGH |
| 16 | PHE338 (6.44x44) | ASN375 (7.45x45) | 0.000 | 5.798 | -5.798 | HIGH |
| 17 | PHE269 | GLN270 | 0.000 | 5.420 | -5.420 | HIGH |
| 18 | ARG218 (5.68x68) | TYR255 | 5.214 | 0.000 | +5.214 | HIGH |
| 19 | ARG222 (5.72x72) | GLY319 (6.25x25) | 0.000 | 5.121 | -5.121 | HIGH |
| 20 | GLU297 | LYS311 | 0.000 | 5.107 | -5.107 | HIGH |
| 21 | ILE118 (3.40x40) | TRP342 (6.48x48) | 5.010 | 0.000 | +5.010 | HIGH |
| 22 | ARG222 (5.72x72) | LEU252 | 4.896 | 0.000 | +4.896 | MED |
| 23 | ASP127 (3.49x49) | ARG128 (3.50x50) | 0.000 | 4.895 | -4.895 | MED |
| 24 | ASN375 (7.45x45) | ASN379 (7.49x49) | 5.026 | 0.246 | +4.781 | MED |
| 25 | ARG128 (3.50x50) | TYR208 (5.58x58) | 4.699 | 0.000 | +4.699 | MED |
| 26 | HIS29 (1.32x32) | GLU90 (2.65x64) | 6.597 | 2.030 | +4.567 | MED |
| 27 | MET330 (6.36x36) | PHE386 (7.56x56) | 5.599 | 1.062 | +4.537 | MED |
| 28 | LYS293 | ARG318 (6.24x24) | 0.000 | 4.490 | -4.490 | MED |
| 29 | TRP342 (6.48x48) | ASN375 (7.45x45) | 7.253 | 2.847 | +4.405 | MED |
| 30 | ASP127 (3.49x49) | ARG149 (4.41x41) | 5.416 | 1.094 | +4.322 | MED |
| 31 | PHE197 (5.47x47) | PHE201 (5.51x51) | 4.264 | 0.000 | +4.264 | MED |
| 32 | VAL320 (6.26x26) | LYS325 (6.31x31) | 4.631 | 0.375 | +4.256 | MED |
| 33 | THR64 (2.39x39) | TYR138 (34.53x53) | 4.530 | 0.515 | +4.015 | MED |
| 34 | ILE333 (6.39x39) | PHE386 (7.56x56) | 0.160 | 4.126 | -3.966 | MED |
| 35 | PHE201 (5.51x51) | PHE338 (6.44x44) | 3.896 | 0.000 | +3.896 | MED |
| 36 | THR385 (7.55x55) | ARG391 (8.51x51) | 3.890 | 0.000 | +3.890 | MED |
| 37 | LEU121 (3.43x43) | TYR383 (7.53x53) | 3.868 | 0.000 | +3.868 | MED |
| 38 | TYR208 (5.58x58) | ALA332 (6.38x38) | 0.000 | 3.866 | -3.866 | MED |
| 39 | THR130 (3.52x52) | ARG149 (4.41x41) | 3.859 | 0.000 | +3.859 | MED |
| 40 | LEU294 | LEU310 | 0.000 | 3.795 | -3.795 | MED |
| 41 | LEU49 (1.52x52) | PHE394 (8.54x54) | 2.641 | 6.428 | -3.787 | MED |
| 42 | PRO135 (34.50x50) | TYR255 | 3.759 | 0.000 | +3.759 | MED |
| 43 | MET330 (6.36x36) | TYR383 (7.53x53) | 0.000 | 3.715 | -3.715 | MED |
| 44 | TRP342 (6.48x48) | GLY372 (7.42x41) | 2.852 | 6.527 | -3.675 | MED |
| 45 | TYR256 | GLU324 (6.30x30) | 3.656 | 0.000 | +3.656 | MED |
| 46 | GLY141 (34.56x56) | SER146 (4.38x38) | 0.000 | 3.544 | -3.544 | MED |
| 47 | ALA263 | ARG323 (6.29x29) | 3.502 | 0.000 | +3.502 | MED |
| 48 | TYR208 (5.58x58) | VAL331 (6.37x37) | 2.576 | 6.019 | -3.443 | MED |
| 49 | TYR212 (5.62x62) | THR328 (6.34x34) | 3.362 | 0.000 | +3.362 | MED |
| 50 | THR174 | ASN185 (5.35x36) | 3.728 | 0.391 | +3.337 | MED |
| 51 | ARG222 (5.72x72) | TYR256 | 3.283 | 0.000 | +3.283 | MED |
| 52 | ARG219 (5.69x69) | GLU324 (6.30x30) | 3.208 | 0.000 | +3.208 | MED |
| 53 | VAL132 (3.54x54) | TYR255 | 3.187 | 0.000 | +3.187 | MED |
| 54 | VAL68 (2.43x43) | TYR383 (7.53x53) | 0.337 | 3.508 | -3.171 | MED |
| 55 | PRO321 (6.27x27) | GLU324 (6.30x30) | 1.407 | 4.564 | -3.157 | MED |
| 56 | VAL133 (3.55x55) | ARG218 (5.68x68) | 0.381 | 3.403 | -3.021 | MED |
| 57 | ILE118 (3.40x40) | PHE338 (6.44x44) | 1.145 | 4.130 | -2.985 | MED |
| 58 | LEU301 | ASN303 | 0.000 | 2.935 | -2.935 | MED |
| 59 | ARG128 (3.50x50) | TYR383 (7.53x53) | 2.865 | 0.000 | +2.865 | MED |
| 60 | ASP261 | GLU389 (8.49x49) | 2.840 | 0.000 | +2.840 | MED |
| 61 | PRO186 | HIS354 | 7.100 | 4.310 | +2.790 | MED |
| 62 | TYR32 | ALA367 | 2.826 | 0.038 | +2.788 | MED |
| 63 | THR384 (7.54x54) | ARG391 (8.51x51) | 0.055 | 2.750 | -2.696 | MED |
| 64 | CYS114 | TRP342 (6.48x48) | 1.935 | 4.602 | -2.667 | MED |
| 65 | GLU389 (8.49x49) | LYS392 | 2.647 | 0.000 | +2.647 | MED |
| 66 | VAL381 | PHE386 (7.56x56) | 2.617 | 0.000 | +2.617 | MED |
| 67 | ARG128 (3.50x50) | TYR138 (34.53x53) | 0.000 | 2.604 | -2.604 | MED |
| 68 | THR63 (2.38x38) | TYR138 (34.53x53) | 0.000 | 2.590 | -2.590 | MED |
| 69 | SER295 | LEU310 | 0.000 | 2.588 | -2.588 | MED |
| 70 | GLU57 | LYS396 | 4.368 | 1.789 | +2.579 | MED |
| 71 | GLU275 | LEU276 | 2.500 | 0.000 | +2.500 | LOW |
| 72 | ARG222 (5.72x72) | GLU324 (6.30x30) | 2.498 | 0.000 | +2.498 | LOW |
| 73 | TYR138 (34.53x53) | ARG149 (4.41x41) | 1.509 | 3.990 | -2.481 | LOW |
| 74 | CYS341 | LEU371 | 5.081 | 7.472 | -2.390 | LOW |
| 75 | LEU296 | THR308 | 0.000 | 2.386 | -2.386 | LOW |
| 76 | PHE345 | PHE346 | 2.981 | 0.620 | +2.361 | LOW |
| 77 | TYR256 | GLN260 | 2.344 | 0.000 | +2.344 | LOW |
| 78 | ALA123 | MET153 | 0.344 | 2.653 | -2.309 | LOW |
| 79 | ILE124 | TYR383 (7.53x53) | 2.288 | 0.000 | +2.288 | LOW |
| 80 | SER257 | ASP261 | 2.650 | 0.372 | +2.278 | LOW |
| 81 | THR204 | PHE338 (6.44x44) | 2.252 | 0.000 | +2.252 | LOW |
| 82 | PRO186 | THR353 | 2.245 | 0.000 | +2.245 | LOW |
| 83 | ASN47 | ALA72 | 6.682 | 4.465 | +2.217 | LOW |
| 84 | TRP85 | PHE98 | 0.000 | 2.214 | -2.214 | LOW |
| 85 | THR385 (7.55x55) | PHE386 (7.56x56) | 1.155 | 3.368 | -2.213 | LOW |
| 86 | VAL320 (6.26x26) | GLU324 (6.30x30) | 0.718 | 2.910 | -2.192 | LOW |
| 87 | TYR208 (5.58x58) | VAL334 | 2.181 | 0.000 | +2.181 | LOW |
| 88 | ASN387 | PHE390 (8.50x50) | 1.939 | 4.116 | -2.176 | LOW |
| 89 | VAL298 | SER307 | 0.000 | 2.146 | -2.146 | LOW |
| 90 | GLU297 | THR308 | 0.000 | 2.141 | -2.141 | LOW |
| 91 | ASP75 | ASN379 (7.49x49) | 5.140 | 3.010 | +2.130 | LOW |
| 92 | ALA74 | SER117 | 3.147 | 1.019 | +2.128 | LOW |
| 93 | PHE197 (5.47x47) | TRP342 (6.48x48) | 3.957 | 1.845 | +2.111 | LOW |
| 94 | THR63 (2.38x38) | CYS147 | 2.102 | 0.000 | +2.102 | LOW |
| 95 | TYR198 | PHE346 | 3.977 | 1.883 | +2.094 | LOW |
| 96 | THR353 | HIS354 | 1.822 | 3.903 | -2.082 | LOW |
| 97 | GLN144 | ARG148 | 2.079 | 0.000 | +2.079 | LOW |
| 98 | LEU11 | ASN12 | 2.053 | 0.000 | +2.053 | LOW |
| 99 | VAL50 | THR384 (7.54x54) | 2.052 | 0.000 | +2.052 | LOW |
| 100 | ARG149 (4.41x41) | MET153 | 2.263 | 0.245 | +2.017 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.54 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 29-49 | 29 (4.6) | 1 | 49 (-3.8) | 1 |
| TM2 | 63-90 | 63 (7.4), 90 (4.6) | 2 | 64 (-8.2), 68 (-3.2) | 2 |
| TM3 | 118-133 | 118 (5.0), 121 (3.9), 130 (3.9), 132 (3.2) | 4 | 128 (-8.2), 127 (-4.9), 133 (-3.0) | 3 |
| TM4 | 146-149 | 149 (4.3) | 1 | 146 (-3.5) | 1 |
| TM5 | 185-222 | 219 (10.3), 218 (5.2), 208 (4.7), 197 (4.3), 201 (4.3), 212 (3.4), 185 (3.3) | 7 | 222 (-5.8) | 1 |
| TM6 | 318-342 | 323 (14.2), 320 (10.3), 330 (4.5), 325 (4.3), 324 (3.7), 328 (3.4) | 6 | 338 (-7.7), 342 (-7.7), 319 (-5.1), 318 (-4.5), 333 (-4.0), 332 (-3.9), 331 (-3.4), 321 (-3.2) | 8 |
| TM7 | 372-386 | 384 (9.6), 379 (4.8), 386 (4.5), 385 (3.9), 383 (3.9) | 5 | 375 (-5.8), 372 (-3.7) | 2 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | - | - | 0 | - | 0 |
| ICL2 | 135-141 | 141 (7.4), 138 (4.0), 135 (3.8) | 3 | - | 0 |
| ICL3 | 252-311 | 260 (14.2), 262 (13.7), 255 (5.2), 252 (4.9), 256 (3.7), 263 (3.5) | 6 | 297 (-8.5), 309 (-8.5), 295 (-7.8), 311 (-7.8), 299 (-7.4), 307 (-7.4), 269 (-5.4), 270 (-5.4), 293 (-4.5), 294 (-3.8), 310 (-3.8) | 11 |
| ECL1 | - | - | 0 | - | 0 |
| ECL2 | 174-174 | 174 (3.3) | 1 | - | 0 |
| ECL3 | - | - | 0 | - | 0 |
| H8 | 388-394 | 388 (13.7), 390 (9.6), 391 (6.1) | 3 | 389 (-8.3), 394 (-3.8) | 2 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
85 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 323 | p.Arg323Gln | c.968G>A | 1.16e-05 | 15 / 1 | 14.20 | 0.277 | BENIGN | 0.82 | rs370774588 |
| 323 | p.Arg323Pro | c.968G>C | 6.84e-07 | 1 / 0 | 14.20 | - | nan | - | rs370774588 |
| 323 | p.Arg323Trp | c.967C>T | 1.03e-05 | 15 / 0 | 14.20 | - | nan | - | rs1258445480 |
| 388 | p.Ile388Thr | c.1163T>C | 1.37e-06 | 2 / 0 | 13.74 | 0.069 | BENIGN | 0.65 | rs371591312 |
| 262 | p.Thr262Ala | c.784A>G | 1.37e-06 | 2 / 0 | 13.74 | 0.061 | BENIGN | 0.47 | rs147915170 |
| 388 | p.Ile388Asn | c.1163T>A | 1.37e-06 | 2 / 0 | 13.74 | - | nan | - | rs371591312 |
| 388 | p.Ile388Phe | c.1162A>T | 6.85e-07 | 1 / 0 | 13.74 | - | nan | - | |
| 219 | p.Arg219Ser | c.657A>T | 6.84e-07 | 1 / 0 | 10.25 | 0.471 | AMBIGUOUS | 0.71 | |
| 219 | p.Arg219Lys | c.656G>A | 1.37e-06 | 0 / 1 | 10.25 | - | nan | - | |
| 390 | p.Phe390Leu | c.1170C>G | 2.06e-06 | 3 / 0 | 9.59 | 0.999 | PATHOGENIC | 1.00 | rs2077399377 |
| 384 | p.Thr384Asn | c.1151C>A | 6.84e-07 | 1 / 0 | 9.59 | 0.975 | PATHOGENIC | 1.00 | rs886057788 |
| 384 | p.Thr384Ala | c.1150A>G | 2.05e-06 | 3 / 0 | 9.59 | - | nan | - | rs1196216612 |
| 297 | p.Glu297Lys | c.889G>A | 6.84e-07 | 1 / 0 | 8.46 | 0.435 | AMBIGUOUS | 0.69 | |
| 309 | p.Ser309Phe | c.926C>T | 6.84e-07 | 1 / 0 | 8.46 | 0.278 | BENIGN | 0.64 | |
| 389 | p.Glu389Lys | c.1165G>A | 2.74e-06 | 4 / 0 | 8.28 | 0.913 | PATHOGENIC | 0.94 | rs1235033455 |
| 389 | p.Glu389Gln | c.1165G>C | 6.86e-07 | 1 / 0 | 8.28 | - | nan | - | rs1235033455 |
| 311 | p.Lys311Met | c.932A>T | 1.37e-06 | 2 / 0 | 7.81 | 0.328 | BENIGN | 0.55 | rs1472202736 |
| 295 | p.Ser295Gly | c.883A>G | 6.84e-07 | 1 / 0 | 7.81 | 0.085 | BENIGN | 0.48 | rs2077427506 |
| 311 | p.Lys311Arg | c.932A>G | 6.84e-07 | 1 / 0 | 7.81 | - | nan | - | rs1472202736 |
| 307 | p.Ser307Leu | c.920C>T | 9.58e-06 | 14 / 0 | 7.39 | 0.116 | BENIGN | 0.40 | rs2077427003 |
| 299 | p.Arg299Gln | c.896G>A | 1.09e-05 | 16 / 0 | 7.39 | 0.082 | BENIGN | 0.62 | rs200082316 |
| 307 | p.Ser307Ala | c.919T>G | 4.10e-06 | 6 / 0 | 7.39 | - | nan | - | rs958347845 |
| 299 | p.Arg299Gly | c.895C>G | 1.37e-06 | 2 / 0 | 7.39 | - | nan | - | |
| 141 | p.Gly141Asp | c.422G>A | 6.84e-07 | 1 / 0 | 7.38 | 0.211 | BENIGN | 0.42 | rs1322253778 |
| 63 | p.Thr63Ala | c.187A>G | 6.84e-07 | 1 / 0 | 7.38 | 0.132 | BENIGN | 0.88 | rs1437485782 |
| 391 | p.Arg391Leu | c.1172G>T | 6.87e-07 | 1 / 0 | 6.06 | 0.990 | PATHOGENIC | 0.99 | |
| 391 | p.Arg391Gln | c.1172G>A | 2.06e-05 | 30 / 0 | 6.06 | - | nan | - | rs746592271 |
| 391 | p.Arg391Trp | c.1171C>T | 4.81e-06 | 7 / 0 | 6.06 | - | nan | - | rs200007633 |
| 222 | p.Arg222Thr | c.665G>C | 6.84e-07 | 1 / 0 | 5.81 | 0.367 | AMBIGUOUS | 0.79 | |
| 375 | p.Asn375Asp | c.1123A>G | 6.84e-07 | 1 / 0 | 5.80 | 0.993 | PATHOGENIC | 1.00 | rs148428613 |
| 270 | p.Gln270Arg | c.809A>G | 6.84e-07 | 1 / 0 | 5.42 | 0.065 | BENIGN | 0.47 | rs1559979434 |
| 218 | p.Arg218Met | c.653G>T | 6.84e-07 | 1 / 0 | 5.21 | 0.856 | PATHOGENIC | 0.76 | |
| 319 | p.Gly319Val | c.956G>T | 6.84e-07 | 1 / 0 | 5.12 | 0.095 | BENIGN | 0.41 | |
| 118 | p.Ile118Thr | c.353T>C | 6.84e-07 | 1 / 0 | 5.01 | 0.991 | PATHOGENIC | 0.96 | |
| 118 | p.Ile118Asn | c.353T>A | 2.05e-06 | 3 / 0 | 5.01 | - | nan | - | rs1396583854 |
| 252 | p.Leu252Met | c.754C>A | 6.84e-07 | 1 / 0 | 4.90 | 0.096 | BENIGN | 0.52 | |
| 252 | p.Leu252Val | c.754C>G | 6.84e-07 | 1 / 0 | 4.90 | - | nan | - | rs1181229994 |
| 379 | p.Asn379Lys | c.1137C>A | 6.84e-07 | 1 / 0 | 4.78 | 0.999 | PATHOGENIC | 1.00 | |
| 379 | p.Asn379Ser | c.1136A>G | 1.37e-06 | 2 / 0 | 4.78 | - | nan | - | |
| 90 | p.Glu90Gly | c.269A>G | 6.92e-07 | 1 / 0 | 4.57 | 0.915 | PATHOGENIC | 0.97 | |
| 29 | p.His29Arg | c.86A>G | 6.86e-07 | 1 / 0 | 4.57 | 0.065 | BENIGN | 0.70 | |
| 29 | p.His29Leu | c.86A>T | 5.49e-06 | 8 / 0 | 4.57 | - | nan | - | rs761362051 |
| 29 | p.His29Asp | c.85C>G | 6.86e-07 | 1 / 0 | 4.57 | - | nan | - | |
| 29 | p.His29Tyr | c.85C>T | 1.37e-06 | 2 / 0 | 4.57 | - | nan | - | |
| 330 | p.Met330Ile | c.990G>A | 1.37e-06 | 2 / 0 | 4.54 | 0.956 | PATHOGENIC | 0.90 | |
| 330 | p.Met330Val | c.988A>G | 1.37e-06 | 2 / 0 | 4.54 | - | nan | - | |
| 293 | p.Lys293Asn | c.879G>C | 6.84e-07 | 1 / 0 | 4.49 | 0.364 | AMBIGUOUS | 0.56 | |
| 318 | p.Arg318Gln | c.953G>A | 1.37e-06 | 2 / 0 | 4.49 | 0.112 | BENIGN | 0.72 | rs201759000 |
| 318 | p.Arg318Trp | c.952C>T | 5.47e-06 | 8 / 0 | 4.49 | - | nan | - | rs1303294486 |
| 293 | p.Lys293Thr | c.878A>C | 6.84e-07 | 1 / 0 | 4.49 | - | nan | - | |
| 149 | p.Arg149His | c.446G>A | 3.49e-05 | 51 / 0 | 4.32 | 0.361 | AMBIGUOUS | 0.93 | rs368221644 |
| 149 | p.Arg149Cys | c.445C>T | 1.37e-06 | 2 / 0 | 4.32 | - | nan | - | rs200010990 |
| 149 | p.Arg149Ser | c.445C>A | 6.84e-07 | 1 / 0 | 4.32 | - | nan | - | |
| 201 | p.Phe201Tyr | c.602T>A | 1.37e-06 | 2 / 0 | 4.26 | 0.835 | PATHOGENIC | 0.87 | rs2077506625 |
| 325 | p.Lys325Asn | c.975G>T | 6.84e-07 | 1 / 0 | 4.26 | 0.879 | PATHOGENIC | 0.82 | rs2077425767 |
| 138 | p.Tyr138Cys | c.413A>G | 1.37e-06 | 2 / 0 | 4.02 | 0.814 | PATHOGENIC | 0.99 | rs969758632 |
| 138 | p.Tyr138His | c.412T>C | 6.57e-06 | 1 / 0 | 4.02 | - | nan | - | rs2077579778 |
| 333 | p.Ile333Thr | c.998T>C | 5.48e-06 | 8 / 0 | 3.97 | 0.543 | AMBIGUOUS | 0.92 | |
| 385 | p.Thr385Ser | c.1154C>G | 5.48e-06 | 8 / 0 | 3.89 | 0.255 | BENIGN | 0.86 | |
| 385 | p.Thr385Ile | c.1154C>T | 6.57e-06 | 1 / 0 | 3.89 | - | nan | - | rs2077399711 |
| 383 | p.Tyr383Cys | c.1148A>G | 6.84e-07 | 1 / 0 | 3.87 | 0.984 | PATHOGENIC | 1.00 | |
| 121 | p.Leu121Ile | c.361C>A | 6.57e-06 | 1 / 0 | 3.87 | 0.739 | PATHOGENIC | 0.95 | rs201447792 |
| 383 | p.Tyr383Ser | c.1148A>C | 6.84e-07 | 1 / 0 | 3.87 | - | nan | - | rs1274871399 |
| 332 | p.Ala332Asp | c.995C>A | 6.58e-06 | 1 / 0 | 3.87 | 0.979 | PATHOGENIC | 0.80 | rs2077425498 |
| 310 | p.Leu310Trp | c.929T>G | 6.84e-07 | 1 / 0 | 3.80 | 0.395 | AMBIGUOUS | 0.67 | rs1165623250 |
| 294 | p.Leu294His | c.881T>A | 6.84e-07 | 1 / 0 | 3.80 | 0.212 | BENIGN | 0.45 | |
| 294 | p.Leu294Arg | c.881T>G | 4.79e-06 | 7 / 0 | 3.80 | - | nan | - | |
| 394 | p.Phe394Cys | c.1181T>G | 6.88e-07 | 1 / 0 | 3.79 | 0.973 | PATHOGENIC | 1.00 | |
| 135 | p.Pro135His | c.404C>A | 4.79e-06 | 7 / 0 | 3.76 | 0.976 | PATHOGENIC | 1.00 | rs199862630 |
| 372 | p.Gly372Asp | c.1115G>A | 6.16e-06 | 9 / 0 | 3.67 | 0.998 | PATHOGENIC | 1.00 | rs754391076 |
| 372 | p.Gly372Arg | c.1114G>C | 6.58e-06 | 1 / 0 | 3.67 | - | nan | - | rs2077400375 |
| 146 | p.Ser146Pro | c.436T>C | 6.58e-06 | 1 / 0 | 3.54 | 0.150 | BENIGN | 0.89 | rs1166704705 |
| 146 | p.Ser146Ala | c.436T>G | 6.84e-07 | 1 / 0 | 3.54 | - | nan | - | |
| 263 | p.Ala263Thr | c.787G>A | 6.84e-07 | 1 / 0 | 3.50 | 0.070 | BENIGN | 0.47 | |
| 331 | p.Val331Ala | c.992T>C | 6.84e-07 | 1 / 0 | 3.44 | 0.733 | PATHOGENIC | 0.85 | rs1300210592 |
| 331 | p.Val331Leu | c.991G>T | 6.84e-07 | 1 / 0 | 3.44 | - | nan | - | |
| 212 | p.Tyr212His | c.634T>C | 6.84e-07 | 1 / 0 | 3.36 | 0.414 | AMBIGUOUS | 0.81 | |
| 185 | p.Asn185Lys | c.555C>G | 6.84e-07 | 1 / 0 | 3.34 | 0.854 | PATHOGENIC | 0.82 | rs2077507183 |
| 132 | p.Val132Ala | c.395T>C | 6.86e-07 | 1 / 0 | 3.19 | 0.907 | PATHOGENIC | 0.99 | |
| 132 | p.Val132Gly | c.395T>G | 2.74e-06 | 4 / 0 | 3.19 | - | nan | - | |
| 68 | p.Val68Ala | c.203T>C | 6.84e-07 | 1 / 0 | 3.17 | 0.952 | PATHOGENIC | 0.80 | |
| 68 | p.Val68Leu | c.202G>C | 6.84e-07 | 1 / 0 | 3.17 | - | nan | - | |
| 68 | p.Val68Leu | c.202G>T | 6.84e-07 | 1 / 0 | 3.17 | - | nan | - | |
| 68 | p.Val68Ile | c.202G>A | 8.89e-06 | 13 / 0 | 3.17 | - | nan | - | rs371939561 |
| 321 | p.Pro321Ser | c.961C>T | 6.84e-07 | 1 / 0 | 3.16 | 0.121 | BENIGN | 0.55 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.54, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 260 | GLN | 323 | ARG | 14.196 | 0.000 | 14.196 | 14.196 |
| 262 | THR | 388 | ILE | 13.738 | 0.000 | 13.738 | 13.738 |
| 219 | ARG | 320 | VAL | 10.253 | 0.000 | 10.253 | 10.253 |
| 384 | THR | 390 | PHE | 9.595 | 0.002 | 9.592 | 9.592 |
| 297 | GLU | 309 | SER | 0.000 | 8.462 | -8.462 | 8.462 |
| 323 | ARG | 389 | GLU | 0.000 | 8.282 | -8.282 | 8.282 |
| 64 | THR | 128 | ARG | 0.000 | 8.247 | -8.247 | 8.247 |
| 262 | THR | 389 | GLU | 8.204 | 0.000 | 8.204 | 8.204 |
| 295 | SER | 311 | LYS | 0.000 | 7.814 | -7.814 | 7.814 |
| 338 | PHE | 342 | TRP | 2.140 | 9.882 | -7.743 | 7.743 |
| 299 | ARG | 307 | SER | 0.000 | 7.387 | -7.387 | 7.387 |
| 63 | THR | 141 | GLY | 7.384 | 0.000 | 7.384 | 7.384 |
| 297 | GLU | 299 | ARG | 0.013 | 6.591 | -6.578 | 6.578 |
| 388 | ILE | 391 | ARG | 6.507 | 0.444 | 6.063 | 6.063 |
| 222 | ARG | 320 | VAL | 0.000 | 5.812 | -5.812 | 5.812 |
| 338 | PHE | 375 | ASN | 0.000 | 5.798 | -5.798 | 5.798 |
| 269 | PHE | 270 | GLN | 0.000 | 5.420 | -5.420 | 5.420 |
| 218 | ARG | 255 | TYR | 5.214 | 0.000 | 5.214 | 5.214 |
| 222 | ARG | 319 | GLY | 0.000 | 5.121 | -5.121 | 5.121 |
| 297 | GLU | 311 | LYS | 0.000 | 5.107 | -5.107 | 5.107 |
| 118 | ILE | 342 | TRP | 5.010 | 0.000 | 5.010 | 5.010 |
| 222 | ARG | 252 | LEU | 4.896 | 0.000 | 4.896 | 4.896 |
| 127 | ASP | 128 | ARG | 0.000 | 4.895 | -4.895 | 4.895 |
| 375 | ASN | 379 | ASN | 5.026 | 0.246 | 4.781 | 4.781 |
| 128 | ARG | 208 | TYR | 4.699 | 0.000 | 4.699 | 4.699 |
| 29 | HIS | 90 | GLU | 6.597 | 2.030 | 4.567 | 4.567 |
| 330 | MET | 386 | PHE | 5.599 | 1.062 | 4.537 | 4.537 |
| 293 | LYS | 318 | ARG | 0.000 | 4.490 | -4.490 | 4.490 |
| 342 | TRP | 375 | ASN | 7.253 | 2.847 | 4.405 | 4.405 |
| 127 | ASP | 149 | ARG | 5.416 | 1.094 | 4.322 | 4.322 |
| 197 | PHE | 201 | PHE | 4.264 | 0.000 | 4.264 | 4.264 |
| 320 | VAL | 325 | LYS | 4.631 | 0.375 | 4.256 | 4.256 |
| 64 | THR | 138 | TYR | 4.530 | 0.515 | 4.015 | 4.015 |
| 333 | ILE | 386 | PHE | 0.160 | 4.126 | -3.966 | 3.966 |
| 201 | PHE | 338 | PHE | 3.896 | 0.000 | 3.896 | 3.896 |
| 385 | THR | 391 | ARG | 3.890 | 0.000 | 3.890 | 3.890 |
| 121 | LEU | 383 | TYR | 3.868 | 0.000 | 3.868 | 3.868 |
| 208 | TYR | 332 | ALA | 0.000 | 3.866 | -3.866 | 3.866 |
| 130 | THR | 149 | ARG | 3.859 | 0.000 | 3.859 | 3.859 |
| 294 | LEU | 310 | LEU | 0.000 | 3.795 | -3.795 | 3.795 |
| 49 | LEU | 394 | PHE | 2.641 | 6.428 | -3.787 | 3.787 |
| 135 | PRO | 255 | TYR | 3.759 | 0.000 | 3.759 | 3.759 |
| 330 | MET | 383 | TYR | 0.000 | 3.715 | -3.715 | 3.715 |
| 342 | TRP | 372 | GLY | 2.852 | 6.527 | -3.675 | 3.675 |
| 256 | TYR | 324 | GLU | 3.656 | 0.000 | 3.656 | 3.656 |
| 141 | GLY | 146 | SER | 0.000 | 3.544 | -3.544 | 3.544 |
| 263 | ALA | 323 | ARG | 3.502 | 0.000 | 3.502 | 3.502 |
| 208 | TYR | 331 | VAL | 2.576 | 6.019 | -3.443 | 3.443 |
| 212 | TYR | 328 | THR | 3.362 | 0.000 | 3.362 | 3.362 |
| 174 | THR | 185 | ASN | 3.728 | 0.391 | 3.337 | 3.337 |
| 222 | ARG | 256 | TYR | 3.283 | 0.000 | 3.283 | 3.283 |
| 219 | ARG | 324 | GLU | 3.208 | 0.000 | 3.208 | 3.208 |
| 132 | VAL | 255 | TYR | 3.187 | 0.000 | 3.187 | 3.187 |
| 68 | VAL | 383 | TYR | 0.337 | 3.508 | -3.171 | 3.171 |
| 321 | PRO | 324 | GLU | 1.407 | 4.564 | -3.157 | 3.157 |
| 133 | VAL | 218 | ARG | 0.381 | 3.403 | -3.021 | 3.021 |
| 118 | ILE | 338 | PHE | 1.145 | 4.130 | -2.985 | 2.985 |
| 301 | LEU | 303 | ASN | 0.000 | 2.935 | -2.935 | 2.935 |
| 128 | ARG | 383 | TYR | 2.865 | 0.000 | 2.865 | 2.865 |
| 261 | ASP | 389 | GLU | 2.840 | 0.000 | 2.840 | 2.840 |
| 186 | PRO | 354 | HIS | 7.100 | 4.310 | 2.790 | 2.790 |
| 32 | TYR | 367 | ALA | 2.826 | 0.038 | 2.788 | 2.788 |
| 384 | THR | 391 | ARG | 0.055 | 2.750 | -2.696 | 2.696 |
| 114 | CYS | 342 | TRP | 1.935 | 4.602 | -2.667 | 2.667 |
| 389 | GLU | 392 | LYS | 2.647 | 0.000 | 2.647 | 2.647 |
| 381 | VAL | 386 | PHE | 2.617 | 0.000 | 2.617 | 2.617 |
| 128 | ARG | 138 | TYR | 0.000 | 2.604 | -2.604 | 2.604 |
| 63 | THR | 138 | TYR | 0.000 | 2.590 | -2.590 | 2.590 |
| 295 | SER | 310 | LEU | 0.000 | 2.588 | -2.588 | 2.588 |
| 57 | GLU | 396 | LYS | 4.368 | 1.789 | 2.579 | 2.579 |
| 275 | GLU | 276 | LEU | 2.500 | 0.000 | 2.500 | 2.500 |
| 222 | ARG | 324 | GLU | 2.498 | 0.000 | 2.498 | 2.498 |
| 138 | TYR | 149 | ARG | 1.509 | 3.990 | -2.481 | 2.481 |
| 341 | CYS | 371 | LEU | 5.081 | 7.472 | -2.390 | 2.390 |
| 296 | LEU | 308 | THR | 0.000 | 2.386 | -2.386 | 2.386 |
| 345 | PHE | 346 | PHE | 2.981 | 0.620 | 2.361 | 2.361 |
| 256 | TYR | 260 | GLN | 2.344 | 0.000 | 2.344 | 2.344 |
| 123 | ALA | 153 | MET | 0.344 | 2.653 | -2.309 | 2.309 |
| 124 | ILE | 383 | TYR | 2.288 | 0.000 | 2.288 | 2.288 |
| 257 | SER | 261 | ASP | 2.650 | 0.372 | 2.278 | 2.278 |
| 204 | THR | 338 | PHE | 2.252 | 0.000 | 2.252 | 2.252 |
| 186 | PRO | 353 | THR | 2.245 | 0.000 | 2.245 | 2.245 |
| 47 | ASN | 72 | ALA | 6.682 | 4.465 | 2.217 | 2.217 |
| 85 | TRP | 98 | PHE | 0.000 | 2.214 | -2.214 | 2.214 |
| 385 | THR | 386 | PHE | 1.155 | 3.368 | -2.213 | 2.213 |
| 320 | VAL | 324 | GLU | 0.718 | 2.910 | -2.192 | 2.192 |
| 208 | TYR | 334 | VAL | 2.181 | 0.000 | 2.181 | 2.181 |
| 387 | ASN | 390 | PHE | 1.939 | 4.116 | -2.176 | 2.176 |
| 298 | VAL | 307 | SER | 0.000 | 2.146 | -2.146 | 2.146 |
| 297 | GLU | 308 | THR | 0.000 | 2.141 | -2.141 | 2.141 |
| 75 | ASP | 379 | ASN | 5.140 | 3.010 | 2.130 | 2.130 |
| 74 | ALA | 117 | SER | 3.147 | 1.019 | 2.128 | 2.128 |
| 197 | PHE | 342 | TRP | 3.957 | 1.845 | 2.111 | 2.111 |
| 63 | THR | 147 | CYS | 2.102 | 0.000 | 2.102 | 2.102 |
| 198 | TYR | 346 | PHE | 3.977 | 1.883 | 2.094 | 2.094 |
| 353 | THR | 354 | HIS | 1.822 | 3.903 | -2.082 | 2.082 |
| 144 | GLN | 148 | ARG | 2.079 | 0.000 | 2.079 | 2.079 |
| 11 | LEU | 12 | ASN | 2.053 | 0.000 | 2.053 | 2.053 |
| 50 | VAL | 384 | THR | 2.052 | 0.000 | 2.052 | 2.052 |
| 149 | ARG | 153 | MET | 2.263 | 0.245 | 2.017 | 2.017 |
| 222 | ARG | 318 | ARG | 0.000 | 2.016 | -2.016 | 2.016 |
| 62 | THR | 141 | GLY | 1.990 | 0.000 | 1.990 | 1.990 |
| 32 | TYR | 370 | TRP | 1.977 | 0.000 | 1.977 | 1.977 |
| 299 | ARG | 306 | LEU | 0.000 | 1.972 | -1.972 | 1.972 |
| 135 | PRO | 218 | ARG | 0.208 | 2.178 | -1.969 | 1.969 |
| 382 | ILE | 383 | TYR | 2.071 | 0.113 | 1.958 | 1.958 |
| 111 | VAL | 165 | SER | 1.649 | 3.584 | -1.935 | 1.935 |
| 108 | THR | 165 | SER | 5.224 | 3.307 | 1.916 | 1.916 |
| 361 | SER | 363 | GLU | 3.665 | 1.754 | 1.911 | 1.911 |
| 390 | PHE | 394 | PHE | 2.545 | 0.645 | 1.900 | 1.900 |
| 236 | PRO | 238 | PHE | 0.000 | 1.875 | -1.875 | 1.875 |
| 296 | LEU | 310 | LEU | 0.000 | 1.872 | -1.872 | 1.872 |
| 99 | SER | 102 | CYS | 0.000 | 1.861 | -1.861 | 1.861 |
| 125 | SER | 207 | VAL | 3.654 | 1.815 | 1.839 | 1.839 |
| 300 | LYS | 305 | ARG | 0.000 | 1.830 | -1.830 | 1.830 |
| 246 | ASP | 247 | PRO | 1.966 | 0.139 | 1.827 | 1.827 |
| 71 | LEU | 120 | ASN | 5.546 | 3.744 | 1.802 | 1.802 |
| 343 | LEU | 347 | LEU | 0.000 | 1.752 | -1.752 | 1.752 |
| 75 | ASP | 117 | SER | 2.262 | 0.519 | 1.743 | 1.743 |
| 188 | PHE | 192 | SER | 3.752 | 2.009 | 1.742 | 1.742 |
| 71 | LEU | 379 | ASN | 3.151 | 1.410 | 1.741 | 1.741 |
| 167 | PRO | 172 | PHE | 6.866 | 5.128 | 1.738 | 1.738 |
| 115 | THR | 196 | SER | 5.332 | 3.598 | 1.734 | 1.734 |
| 125 | SER | 204 | THR | 2.781 | 1.056 | 1.725 | 1.725 |
| 226 | ARG | 288 | PRO | 0.000 | 1.714 | -1.714 | 1.714 |
| 262 | THR | 392 | LYS | 1.693 | 0.000 | 1.693 | 1.693 |
| 131 | ALA | 255 | TYR | 1.673 | 0.000 | 1.673 | 1.673 |
| 286 | LEU | 287 | SER | 1.665 | 0.000 | 1.665 | 1.665 |
| 64 | THR | 127 | ASP | 1.942 | 3.607 | -1.665 | 1.665 |
| 352 | ASN | 365 | TYR | 1.662 | 0.000 | 1.662 | 1.662 |
| 204 | THR | 335 | LEU | 0.737 | 2.384 | -1.647 | 1.647 |
| 124 | ILE | 128 | ARG | 1.900 | 0.286 | 1.614 | 1.614 |
| 383 | TYR | 390 | PHE | 0.000 | 1.613 | -1.613 | 1.613 |
| 190 | ILE | 354 | HIS | 6.766 | 5.168 | 1.598 | 1.598 |
| 52 | MET | 56 | LYS | 0.000 | 1.595 | -1.595 | 1.595 |
| 54 | VAL | 65 | ASN | 0.061 | 1.635 | -1.574 | 1.574 |
| 302 | SER | 303 | ASN | 1.567 | 0.000 | 1.567 | 1.567 |
| 50 | VAL | 394 | PHE | 1.674 | 3.233 | -1.559 | 1.559 |
| 100 | ARG | 178 | PRO | 9.505 | 11.059 | -1.554 | 1.554 |
| 175 | THR | 182 | SER | 3.142 | 1.587 | 1.554 | 1.554 |
| 88 | TYR | 97 | ASN | 3.316 | 4.869 | -1.553 | 1.553 |
| 88 | TYR | 98 | PHE | 4.657 | 6.202 | -1.545 | 1.545 |
| 88 | TYR | 96 | TRP | 0.000 | 1.541 | -1.541 | 1.541 |
| 168 | LEU | 173 | ASN | 1.665 | 0.141 | 1.524 | 1.524 |
| 124 | ILE | 331 | VAL | 0.000 | 1.516 | -1.516 | 1.516 |
| 60 | LEU | 390 | PHE | 4.587 | 3.076 | 1.511 | 1.511 |
| 134 | MET | 137 | HIS | 2.000 | 0.495 | 1.505 | 1.505 |
| 50 | VAL | 383 | TYR | 0.000 | 1.501 | -1.501 | 1.501 |
| 107 | VAL | 173 | ASN | 1.496 | 0.000 | 1.496 | 1.496 |
| 75 | ASP | 376 | SER | 10.977 | 9.487 | 1.491 | 1.491 |
| 104 | ASP | 168 | LEU | 2.294 | 0.814 | 1.480 | 1.480 |
| 67 | LEU | 127 | ASP | 2.100 | 0.643 | 1.457 | 1.457 |
| 210 | ARG | 214 | VAL | 1.445 | 0.000 | 1.445 | 1.445 |
| 201 | PHE | 339 | ILE | 1.707 | 3.151 | -1.444 | 1.444 |
| 29 | HIS | 93 | GLY | 1.441 | 0.000 | 1.441 | 1.441 |
| 290 | ILE | 315 | LEU | 0.000 | 1.432 | -1.432 | 1.432 |
| 305 | ARG | 306 | LEU | 1.425 | 0.000 | 1.425 | 1.425 |
| 136 | VAL | 140 | HIS | 0.000 | 1.420 | -1.420 | 1.420 |
| 121 | LEU | 379 | ASN | 1.420 | 0.000 | 1.420 | 1.420 |
| 285 | SER | 286 | LEU | 1.415 | 0.000 | 1.415 | 1.415 |
| 121 | LEU | 338 | PHE | 1.480 | 2.887 | -1.407 | 1.407 |
| 340 | VAL | 371 | LEU | 2.285 | 0.883 | 1.403 | 1.403 |
| 204 | THR | 208 | TYR | 1.390 | 0.000 | 1.390 | 1.390 |
| 45 | PHE | 49 | LEU | 3.634 | 2.256 | 1.378 | 1.378 |
| 289 | THR | 290 | ILE | 1.354 | 0.000 | 1.354 | 1.354 |
| 47 | ASN | 380 | PRO | 5.692 | 4.340 | 1.353 | 1.353 |
| 46 | GLY | 380 | PRO | 3.157 | 4.497 | -1.341 | 1.341 |
| 100 | ARG | 175 | THR | 8.222 | 6.896 | 1.326 | 1.326 |
| 70 | SER | 120 | ASN | 8.134 | 6.834 | 1.300 | 1.300 |
| 110 | ASP | 114 | CYS | 1.288 | 0.000 | 1.288 | 1.288 |
| 43 | ILE | 376 | SER | 4.006 | 2.722 | 1.284 | 1.284 |
| 205 | VAL | 335 | LEU | 1.243 | 0.000 | 1.243 | 1.243 |
| 381 | VAL | 385 | THR | 1.460 | 0.223 | 1.237 | 1.237 |
| 49 | LEU | 398 | LEU | 0.000 | 1.223 | -1.223 | 1.223 |
| 166 | CYS | 170 | PHE | 0.224 | 1.446 | -1.221 | 1.221 |
| 330 | MET | 387 | ASN | 0.000 | 1.212 | -1.212 | 1.212 |
| 125 | SER | 208 | TYR | 4.492 | 3.285 | 1.207 | 1.207 |
| 36 | TYR | 370 | TRP | 8.510 | 7.307 | 1.203 | 1.203 |
| 296 | LEU | 309 | SER | 0.000 | 1.185 | -1.185 | 1.185 |
| 282 | THR | 284 | ASN | 0.000 | 1.177 | -1.177 | 1.177 |
| 85 | TRP | 106 | PHE | 3.871 | 5.040 | -1.169 | 1.169 |
| 119 | LEU | 160 | LEU | 2.263 | 1.096 | 1.167 | 1.167 |
| 189 | VAL | 349 | HIS | 4.042 | 2.879 | 1.164 | 1.164 |
| 292 | PRO | 312 | LEU | 0.000 | 1.163 | -1.163 | 1.163 |
| 78 | VAL | 113 | MET | 2.678 | 1.524 | 1.155 | 1.155 |
| 189 | VAL | 353 | THR | 3.762 | 2.615 | 1.148 | 1.148 |
| 88 | TYR | 95 | VAL | 0.393 | 1.540 | -1.147 | 1.147 |
| 118 | ILE | 346 | PHE | 1.226 | 0.084 | 1.141 | 1.141 |
| 192 | SER | 196 | SER | 0.000 | 1.140 | -1.140 | 1.140 |
| 299 | ARG | 311 | LYS | 0.000 | 1.138 | -1.138 | 1.138 |
| 380 | PRO | 385 | THR | 1.135 | 0.000 | 1.135 | 1.135 |
| 45 | PHE | 398 | LEU | 0.000 | 1.129 | -1.129 | 1.129 |
| 40 | ILE | 83 | MET | 4.704 | 3.577 | 1.127 | 1.127 |
| 137 | HIS | 146 | SER | 1.126 | 0.000 | 1.126 | 1.126 |
| 107 | VAL | 168 | LEU | 2.664 | 1.539 | 1.125 | 1.125 |
| 339 | ILE | 344 | PRO | 1.566 | 0.443 | 1.123 | 1.123 |
| 342 | TRP | 345 | PHE | 0.691 | 1.811 | -1.120 | 1.120 |
| 164 | VAL | 192 | SER | 1.117 | 0.000 | 1.117 | 1.117 |
| 193 | SER | 346 | PHE | 3.534 | 2.420 | 1.115 | 1.115 |
| 35 | SER | 370 | TRP | 3.867 | 2.772 | 1.095 | 1.095 |
| 112 | MET | 113 | MET | 2.363 | 1.269 | 1.094 | 1.094 |
| 54 | VAL | 60 | LEU | 2.594 | 1.504 | 1.090 | 1.090 |
| 256 | TYR | 323 | ARG | 1.085 | 0.000 | 1.085 | 1.085 |
| 184 | SER | 353 | THR | 1.081 | 0.000 | 1.081 | 1.081 |
| 63 | THR | 146 | SER | 2.862 | 1.788 | 1.074 | 1.074 |
| 198 | TYR | 350 | VAL | 1.284 | 0.210 | 1.074 | 1.074 |
| 138 | TYR | 258 | ILE | 1.069 | 0.000 | 1.069 | 1.069 |
| 337 | ALA | 375 | ASN | 0.113 | 1.171 | -1.057 | 1.057 |
| 301 | LEU | 307 | SER | 0.000 | 1.051 | -1.051 | 1.051 |
| 218 | ARG | 320 | VAL | 0.000 | 1.046 | -1.046 | 1.046 |
| 349 | HIS | 365 | TYR | 4.881 | 3.838 | 1.043 | 1.043 |
| 130 | THR | 138 | TYR | 0.316 | 1.358 | -1.042 | 1.042 |
| 65 | ASN | 390 | PHE | 3.048 | 2.016 | 1.031 | 1.031 |
| 348 | THR | 365 | TYR | 1.202 | 0.175 | 1.027 | 1.027 |
| 347 | LEU | 351 | LEU | 1.025 | 0.000 | 1.025 | 1.025 |
| 168 | LEU | 188 | PHE | 5.584 | 6.603 | -1.020 | 1.020 |
| 341 | CYS | 375 | ASN | 3.567 | 2.552 | 1.015 | 1.015 |
| 298 | VAL | 306 | LEU | 0.000 | 1.012 | -1.012 | 1.012 |
| 132 | VAL | 215 | LEU | 0.169 | 1.179 | -1.010 | 1.010 |
| 355 | CYS | 357 | THR | 0.000 | 1.003 | -1.003 | 1.003 |
| 303 | ASN | 305 | ARG | 0.000 | 0.985 | -0.985 | 0.985 |
| 334 | VAL | 382 | ILE | 1.057 | 2.039 | -0.981 | 0.981 |
| 387 | ASN | 389 | GLU | 0.995 | 1.967 | -0.972 | 0.972 |
| 310 | LEU | 312 | LEU | 0.961 | 0.000 | 0.961 | 0.961 |
| 83 | MET | 373 | TYR | 0.319 | 1.275 | -0.956 | 0.956 |
| 164 | VAL | 188 | PHE | 1.703 | 0.746 | 0.956 | 0.956 |
| 32 | TYR | 36 | TYR | 1.170 | 0.218 | 0.952 | 0.952 |
| 122 | CYS | 203 | VAL | 0.952 | 0.000 | 0.952 | 0.952 |
| 297 | GLU | 307 | SER | 0.000 | 0.945 | -0.945 | 0.945 |
| 128 | ARG | 211 | ILE | 1.443 | 0.503 | 0.940 | 0.940 |
| 82 | VAL | 106 | PHE | 1.899 | 2.839 | -0.940 | 0.940 |
| 326 | LYS | 386 | PHE | 0.936 | 0.000 | 0.936 | 0.936 |
| 164 | VAL | 191 | TYR | 0.000 | 0.930 | -0.930 | 0.930 |
| 71 | LEU | 117 | SER | 1.939 | 2.838 | -0.899 | 0.899 |
| 166 | CYS | 167 | PRO | 1.623 | 0.730 | 0.892 | 0.892 |
| 121 | LEU | 334 | VAL | 0.000 | 0.892 | -0.892 | 0.892 |
| 160 | LEU | 195 | VAL | 0.890 | 0.000 | 0.890 | 0.890 |
| 333 | ILE | 382 | ILE | 0.247 | 1.130 | -0.883 | 0.883 |
| 293 | LYS | 313 | GLY | 0.000 | 0.881 | -0.881 | 0.881 |
| 36 | TYR | 86 | VAL | 2.748 | 1.868 | 0.880 | 0.880 |
| 37 | CYS | 87 | VAL | 1.385 | 0.512 | 0.873 | 0.873 |
| 128 | ARG | 131 | ALA | 0.000 | 0.858 | -0.858 | 0.858 |
| 193 | SER | 349 | HIS | 0.856 | 0.000 | 0.856 | 0.856 |
| 191 | TYR | 195 | VAL | 2.115 | 1.260 | 0.855 | 0.855 |
| 238 | PHE | 239 | PRO | 1.379 | 0.529 | 0.850 | 0.850 |
| 185 | ASN | 188 | PHE | 0.723 | 1.571 | -0.848 | 0.848 |
| 99 | SER | 101 | ILE | 1.517 | 0.671 | 0.846 | 0.846 |
| 129 | TYR | 210 | ARG | 1.577 | 0.739 | 0.838 | 0.838 |
| 195 | VAL | 200 | PRO | 2.085 | 2.921 | -0.836 | 0.836 |
| 175 | THR | 184 | SER | 0.617 | 1.451 | -0.834 | 0.834 |
| 49 | LEU | 52 | MET | 0.833 | 0.000 | 0.833 | 0.833 |
| 57 | GLU | 393 | ALA | 1.113 | 0.288 | 0.826 | 0.826 |
| 63 | THR | 127 | ASP | 0.000 | 0.823 | -0.823 | 0.823 |
| 111 | VAL | 192 | SER | 0.000 | 0.821 | -0.821 | 0.821 |
| 110 | ASP | 373 | TYR | 4.937 | 4.118 | 0.820 | 0.820 |
| 345 | PHE | 365 | TYR | 0.705 | 1.516 | -0.811 | 0.811 |
| 112 | MET | 165 | SER | 4.026 | 4.835 | -0.810 | 0.810 |
| 63 | THR | 142 | THR | 0.810 | 0.000 | 0.810 | 0.810 |
| 261 | ASP | 387 | ASN | 0.807 | 0.000 | 0.807 | 0.807 |
| 71 | LEU | 121 | LEU | 1.571 | 0.770 | 0.800 | 0.800 |
| 150 | VAL | 153 | MET | 0.793 | 0.000 | 0.793 | 0.793 |
| 57 | GLU | 59 | ALA | 0.000 | 0.790 | -0.790 | 0.790 |
| 40 | ILE | 84 | PRO | 1.033 | 0.247 | 0.786 | 0.786 |
| 294 | LEU | 311 | LYS | 0.000 | 0.785 | -0.785 | 0.785 |
| 348 | THR | 364 | LEU | 1.289 | 0.513 | 0.776 | 0.776 |
| 197 | PHE | 346 | PHE | 13.976 | 13.201 | 0.775 | 0.775 |
| 39 | LEU | 83 | MET | 2.121 | 1.348 | 0.773 | 0.773 |
| 104 | ASP | 173 | ASN | 2.837 | 3.609 | -0.772 | 0.772 |
| 121 | LEU | 375 | ASN | 0.769 | 0.000 | 0.769 | 0.769 |
| 113 | MET | 158 | TRP | 1.071 | 1.837 | -0.766 | 0.766 |
| 320 | VAL | 321 | PRO | 1.232 | 0.473 | 0.759 | 0.759 |
| 208 | TYR | 328 | THR | 0.000 | 0.759 | -0.759 | 0.759 |
| 334 | VAL | 379 | ASN | 0.000 | 0.755 | -0.755 | 0.755 |
| 138 | TYR | 142 | THR | 0.000 | 0.748 | -0.748 | 0.748 |
| 5 | SER | 6 | GLN | 0.748 | 0.000 | 0.748 | 0.748 |
| 71 | LEU | 75 | ASP | 1.352 | 0.610 | 0.743 | 0.743 |
| 118 | ILE | 196 | SER | 3.021 | 3.763 | -0.742 | 0.742 |
| 96 | TRP | 98 | PHE | 4.108 | 3.368 | 0.740 | 0.740 |
| 67 | LEU | 124 | ILE | 2.143 | 2.883 | -0.740 | 0.740 |
| 382 | ILE | 386 | PHE | 0.000 | 0.736 | -0.736 | 0.736 |
| 115 | THR | 164 | VAL | 0.000 | 0.731 | -0.731 | 0.731 |
| 90 | GLU | 366 | SER | 1.513 | 2.238 | -0.725 | 0.725 |
| 67 | LEU | 150 | VAL | 1.196 | 0.472 | 0.724 | 0.724 |
| 335 | LEU | 339 | ILE | 0.000 | 0.723 | -0.723 | 0.723 |
| 129 | TYR | 133 | VAL | 4.665 | 3.950 | 0.715 | 0.715 |
| 96 | TRP | 103 | CYS | 5.549 | 6.260 | -0.711 | 0.711 |
| 211 | ILE | 328 | THR | 0.000 | 0.709 | -0.709 | 0.709 |
| 384 | THR | 394 | PHE | 3.449 | 2.740 | 0.708 | 0.708 |
| 199 | LEU | 200 | PRO | 1.408 | 2.114 | -0.706 | 0.706 |
| 388 | ILE | 392 | LYS | 0.122 | 0.821 | -0.699 | 0.699 |
| 174 | THR | 184 | SER | 0.898 | 0.200 | 0.698 | 0.698 |
| 295 | SER | 313 | GLY | 0.000 | 0.697 | -0.697 | 0.697 |
| 47 | ASN | 75 | ASP | 4.835 | 4.142 | 0.693 | 0.693 |
| 140 | HIS | 142 | THR | 0.686 | 0.000 | 0.686 | 0.686 |
| 243 | LEU | 244 | SER | 0.000 | 0.686 | -0.686 | 0.686 |
| 100 | ARG | 176 | GLY | 0.694 | 0.010 | 0.683 | 0.683 |
| 66 | TYR | 154 | ILE | 1.492 | 0.810 | 0.682 | 0.682 |
| 74 | ALA | 113 | MET | 0.628 | 1.304 | -0.676 | 0.676 |
| 68 | VAL | 384 | THR | 0.670 | 0.000 | 0.670 | 0.670 |
| 33 | ALA | 87 | VAL | 0.915 | 0.248 | 0.666 | 0.666 |
| 112 | MET | 162 | PHE | 1.641 | 2.299 | -0.658 | 0.658 |
| 295 | SER | 309 | SER | 0.000 | 0.658 | -0.658 | 0.658 |
| 201 | PHE | 205 | VAL | 1.896 | 2.552 | -0.656 | 0.656 |
| 365 | TYR | 369 | THR | 1.864 | 1.213 | 0.651 | 0.651 |
| 96 | TRP | 106 | PHE | 0.833 | 0.183 | 0.650 | 0.650 |
| 128 | ARG | 334 | VAL | 0.645 | 0.000 | 0.645 | 0.645 |
| 114 | CYS | 373 | TYR | 0.645 | 0.000 | 0.645 | 0.645 |
| 298 | VAL | 308 | THR | 0.000 | 0.643 | -0.643 | 0.643 |
| 172 | PHE | 185 | ASN | 3.465 | 2.824 | 0.641 | 0.641 |
| 183 | ILE | 189 | VAL | 1.071 | 1.702 | -0.631 | 0.631 |
| 112 | MET | 161 | ALA | 3.113 | 2.483 | 0.630 | 0.630 |
| 292 | PRO | 293 | LYS | 0.623 | 0.000 | 0.623 | 0.623 |
| 116 | ALA | 158 | TRP | 1.747 | 1.134 | 0.613 | 0.613 |
| 119 | LEU | 200 | PRO | 0.964 | 0.359 | 0.605 | 0.605 |
| 118 | ILE | 200 | PRO | 0.751 | 1.354 | -0.603 | 0.603 |
| 51 | CYS | 69 | VAL | 0.098 | 0.691 | -0.593 | 0.593 |
| 47 | ASN | 376 | SER | 1.889 | 2.473 | -0.584 | 0.584 |
| 133 | VAL | 214 | VAL | 0.078 | 0.659 | -0.581 | 0.581 |
| 59 | ALA | 323 | ARG | 0.000 | 0.578 | -0.578 | 0.578 |
| 62 | THR | 64 | THR | 0.862 | 0.286 | 0.576 | 0.576 |
| 129 | TYR | 211 | ILE | 3.199 | 3.765 | -0.566 | 0.566 |
| 162 | PHE | 166 | CYS | 0.594 | 1.158 | -0.564 | 0.564 |
| 96 | TRP | 180 | VAL | 0.639 | 0.075 | 0.564 | 0.564 |
| 345 | PHE | 369 | THR | 3.910 | 3.347 | 0.563 | 0.563 |
| 139 | GLN | 140 | HIS | 0.552 | 0.000 | 0.552 | 0.552 |
| 197 | PHE | 343 | LEU | 4.338 | 3.790 | 0.547 | 0.547 |
| 98 | PHE | 102 | CYS | 0.835 | 0.288 | 0.546 | 0.546 |
| 351 | LEU | 360 | VAL | 0.639 | 0.096 | 0.544 | 0.544 |
| 370 | TRP | 374 | VAL | 3.286 | 3.828 | -0.542 | 0.542 |
| 108 | THR | 168 | LEU | 2.809 | 3.351 | -0.542 | 0.542 |
| 33 | ALA | 90 | GLU | 0.538 | 0.000 | 0.538 | 0.538 |
| 71 | LEU | 124 | ILE | 0.716 | 0.179 | 0.537 | 0.537 |
| 188 | PHE | 191 | TYR | 0.000 | 0.535 | -0.535 | 0.535 |
| 212 | TYR | 216 | LYS | 0.602 | 1.126 | -0.525 | 0.525 |
| 127 | ASP | 150 | VAL | 0.524 | 0.000 | 0.524 | 0.524 |
| 149 | ARG | 150 | VAL | 0.523 | 0.000 | 0.523 | 0.523 |
| 214 | VAL | 218 | ARG | 1.216 | 1.734 | -0.518 | 0.518 |
| 299 | ARG | 305 | ARG | 0.000 | 0.517 | -0.517 | 0.517 |
| 132 | VAL | 214 | VAL | 0.923 | 0.406 | 0.517 | 0.517 |
| 70 | SER | 154 | ILE | 1.807 | 2.320 | -0.513 | 0.513 |
| 96 | TRP | 181 | CYS | 4.009 | 4.520 | -0.511 | 0.511 |
| 100 | ARG | 180 | VAL | 2.505 | 1.995 | 0.510 | 0.510 |
| 112 | MET | 158 | TRP | 0.759 | 1.269 | -0.509 | 0.509 |
| 118 | ILE | 197 | PHE | 0.665 | 1.172 | -0.507 | 0.507 |
| 215 | LEU | 320 | VAL | 0.000 | 0.503 | -0.503 | 0.503 |
| 331 | VAL | 335 | LEU | 0.501 | 0.000 | 0.501 | 0.501 |
| 46 | GLY | 394 | PHE | 0.000 | 0.495 | -0.495 | 0.495 |
| 67 | LEU | 154 | ILE | 1.345 | 0.850 | 0.495 | 0.495 |
| 74 | ALA | 116 | ALA | 0.736 | 0.247 | 0.489 | 0.489 |
| 132 | VAL | 328 | THR | 0.000 | 0.486 | -0.486 | 0.486 |
| 122 | CYS | 126 | ILE | 0.475 | 0.000 | 0.475 | 0.475 |
| 9 | SER | 10 | HIS | 0.676 | 0.202 | 0.474 | 0.474 |
| 131 | ALA | 258 | ILE | 0.474 | 0.000 | 0.474 | 0.474 |
| 89 | LEU | 106 | PHE | 1.245 | 0.774 | 0.471 | 0.471 |
| 50 | VAL | 380 | PRO | 0.814 | 1.283 | -0.469 | 0.469 |
| 361 | SER | 362 | PRO | 1.102 | 0.634 | 0.468 | 0.468 |
| 358 | CYS | 360 | VAL | 0.468 | 0.000 | 0.468 | 0.468 |
| 40 | ILE | 79 | ALA | 2.389 | 1.923 | 0.466 | 0.466 |
| 180 | VAL | 182 | SER | 0.820 | 0.357 | 0.462 | 0.462 |
| 215 | LEU | 328 | THR | 0.000 | 0.462 | -0.462 | 0.462 |
| 197 | PHE | 198 | TYR | 2.677 | 3.138 | -0.461 | 0.461 |
| 78 | VAL | 114 | CYS | 0.461 | 0.000 | 0.461 | 0.461 |
| 334 | VAL | 383 | TYR | 1.191 | 0.733 | 0.457 | 0.457 |
| 362 | PRO | 363 | GLU | 1.100 | 1.555 | -0.455 | 0.455 |
| 379 | ASN | 383 | TYR | 0.863 | 1.313 | -0.450 | 0.450 |
| 294 | LEU | 312 | LEU | 0.000 | 0.448 | -0.448 | 0.448 |
| 78 | VAL | 376 | SER | 0.448 | 0.000 | 0.448 | 0.448 |
| 352 | ASN | 360 | VAL | 2.131 | 1.684 | 0.447 | 0.447 |
| 127 | ASP | 153 | MET | 0.834 | 0.390 | 0.444 | 0.444 |
| 43 | ILE | 377 | ALA | 2.282 | 1.840 | 0.442 | 0.442 |
| 94 | GLY | 180 | VAL | 0.456 | 0.016 | 0.439 | 0.439 |
| 2 | ALA | 3 | SER | 1.051 | 1.488 | -0.437 | 0.437 |
| 119 | LEU | 161 | ALA | 0.673 | 1.110 | -0.436 | 0.436 |
| 114 | CYS | 118 | ILE | 0.000 | 0.435 | -0.435 | 0.435 |
| 133 | VAL | 134 | MET | 0.224 | 0.658 | -0.435 | 0.435 |
| 351 | LEU | 355 | CYS | 0.534 | 0.100 | 0.433 | 0.433 |
| 350 | VAL | 354 | HIS | 0.000 | 0.432 | -0.432 | 0.432 |
| 31 | TYR | 32 | TYR | 0.426 | 0.000 | 0.426 | 0.426 |
| 361 | SER | 364 | LEU | 0.511 | 0.936 | -0.425 | 0.425 |
| 111 | VAL | 164 | VAL | 0.422 | 0.000 | 0.422 | 0.422 |
| 120 | ASN | 157 | VAL | 3.514 | 3.932 | -0.419 | 0.419 |
| 130 | THR | 134 | MET | 0.225 | 0.640 | -0.415 | 0.415 |
| 139 | GLN | 254 | ARG | 0.414 | 0.000 | 0.414 | 0.414 |
| 89 | LEU | 96 | TRP | 1.977 | 1.563 | 0.414 | 0.414 |
| 63 | THR | 64 | THR | 0.241 | 0.654 | -0.413 | 0.413 |
| 47 | ASN | 76 | LEU | 2.381 | 1.974 | 0.408 | 0.408 |
| 359 | HIS | 361 | SER | 0.000 | 0.407 | -0.407 | 0.407 |
| 59 | ALA | 389 | GLU | 0.000 | 0.404 | -0.404 | 0.404 |
| 175 | THR | 180 | VAL | 1.495 | 1.897 | -0.402 | 0.402 |
| 208 | TYR | 335 | LEU | 2.588 | 2.187 | 0.402 | 0.402 |
| 128 | ARG | 331 | VAL | 0.000 | 0.401 | -0.401 | 0.401 |
| 64 | THR | 124 | ILE | 0.000 | 0.400 | -0.400 | 0.400 |
| 281 | LYS | 282 | THR | 0.398 | 0.000 | 0.398 | 0.398 |
| 316 | GLN | 317 | PRO | 0.786 | 0.388 | 0.397 | 0.397 |
| 114 | CYS | 346 | PHE | 0.000 | 0.395 | -0.395 | 0.395 |
| 296 | LEU | 298 | VAL | 0.647 | 0.254 | 0.393 | 0.393 |
| 185 | ASN | 353 | THR | 0.390 | 0.000 | 0.390 | 0.390 |
| 264 | LEU | 323 | ARG | 0.390 | 0.000 | 0.390 | 0.390 |
| 62 | THR | 65 | ASN | 3.726 | 4.113 | -0.387 | 0.387 |
| 125 | SER | 126 | ILE | 0.387 | 0.000 | 0.387 | 0.387 |
| 74 | ALA | 120 | ASN | 0.450 | 0.064 | 0.386 | 0.386 |
| 337 | ALA | 382 | ILE | 0.908 | 0.526 | 0.382 | 0.382 |
| 54 | VAL | 61 | GLN | 2.601 | 2.221 | 0.380 | 0.380 |
| 291 | ALA | 292 | PRO | 0.083 | 0.463 | -0.380 | 0.380 |
| 300 | LYS | 306 | LEU | 0.000 | 0.379 | -0.379 | 0.379 |
| 132 | VAL | 218 | ARG | 4.983 | 5.362 | -0.379 | 0.379 |
| 148 | ARG | 152 | LEU | 0.000 | 0.378 | -0.378 | 0.378 |
| 32 | TYR | 35 | SER | 0.000 | 0.377 | -0.377 | 0.377 |
| 68 | VAL | 124 | ILE | 0.567 | 0.937 | -0.370 | 0.370 |
| 216 | LYS | 220 | ARG | 2.345 | 1.975 | 0.370 | 0.370 |
| 124 | ILE | 208 | TYR | 0.368 | 0.000 | 0.368 | 0.368 |
| 164 | VAL | 196 | SER | 1.273 | 0.908 | 0.365 | 0.365 |
| 131 | ALA | 138 | TYR | 7.133 | 7.497 | -0.363 | 0.363 |
| 138 | TYR | 146 | SER | 0.361 | 0.000 | 0.361 | 0.361 |
| 223 | ILE | 227 | GLN | 0.567 | 0.208 | 0.360 | 0.360 |
| 71 | LEU | 383 | TYR | 1.220 | 0.867 | 0.353 | 0.353 |
| 173 | ASN | 182 | SER | 1.660 | 2.012 | -0.352 | 0.352 |
| 82 | VAL | 110 | ASP | 4.508 | 4.161 | 0.347 | 0.347 |
| 111 | VAL | 183 | ILE | 0.923 | 0.579 | 0.344 | 0.344 |
| 277 | LYS | 278 | ARG | 0.343 | 0.000 | 0.343 | 0.343 |
| 126 | ILE | 153 | MET | 0.340 | 0.000 | 0.340 | 0.340 |
| 142 | THR | 146 | SER | 0.000 | 0.337 | -0.337 | 0.337 |
| 81 | LEU | 109 | LEU | 0.707 | 0.373 | 0.334 | 0.334 |
| 74 | ALA | 158 | TRP | 2.440 | 2.110 | 0.329 | 0.329 |
| 36 | TYR | 90 | GLU | 1.867 | 2.195 | -0.327 | 0.327 |
| 385 | THR | 394 | PHE | 0.324 | 0.000 | 0.324 | 0.324 |
| 96 | TRP | 102 | CYS | 3.377 | 3.055 | 0.323 | 0.323 |
| 32 | TYR | 90 | GLU | 0.891 | 0.570 | 0.321 | 0.321 |
| 85 | TRP | 96 | TRP | 1.486 | 1.806 | -0.321 | 0.321 |
| 57 | GLU | 60 | LEU | 1.048 | 1.368 | -0.320 | 0.320 |
| 63 | THR | 149 | ARG | 0.000 | 0.316 | -0.316 | 0.316 |
| 105 | VAL | 169 | LEU | 0.346 | 0.660 | -0.313 | 0.313 |
| 380 | PRO | 394 | PHE | 0.000 | 0.309 | -0.309 | 0.309 |
| 276 | LEU | 277 | LYS | 0.309 | 0.000 | 0.309 | 0.309 |
| 95 | VAL | 179 | THR | 2.088 | 1.783 | 0.305 | 0.305 |
| 111 | VAL | 168 | LEU | 1.233 | 0.929 | 0.304 | 0.304 |
| 78 | VAL | 117 | SER | 0.304 | 0.000 | 0.304 | 0.304 |
| 360 | VAL | 365 | TYR | 0.000 | 0.302 | -0.302 | 0.302 |
| 177 | ASP | 179 | THR | 5.865 | 5.564 | 0.301 | 0.301 |
| 351 | LEU | 358 | CYS | 0.626 | 0.325 | 0.301 | 0.301 |
| 88 | TYR | 89 | LEU | 0.000 | 0.300 | -0.300 | 0.300 |
| 66 | TYR | 150 | VAL | 0.326 | 0.620 | -0.294 | 0.294 |
| 160 | LEU | 164 | VAL | 0.293 | 0.000 | 0.293 | 0.293 |
| 293 | LYS | 312 | LEU | 0.000 | 0.290 | -0.290 | 0.290 |
| 63 | THR | 150 | VAL | 3.551 | 3.262 | 0.289 | 0.289 |
| 70 | SER | 158 | TRP | 2.768 | 2.481 | 0.288 | 0.288 |
| 95 | VAL | 97 | ASN | 1.053 | 1.340 | -0.287 | 0.287 |
| 32 | TYR | 366 | SER | 0.285 | 0.000 | 0.285 | 0.285 |
| 49 | LEU | 397 | ILE | 0.709 | 0.989 | -0.280 | 0.280 |
| 122 | CYS | 200 | PRO | 2.405 | 2.683 | -0.279 | 0.279 |
| 177 | ASP | 180 | VAL | 0.250 | 0.527 | -0.277 | 0.277 |
| 330 | MET | 333 | ILE | 0.276 | 0.000 | 0.276 | 0.276 |
| 53 | ALA | 60 | LEU | 2.429 | 2.158 | 0.271 | 0.271 |
| 210 | ARG | 213 | VAL | 0.267 | 0.000 | 0.267 | 0.267 |
| 35 | SER | 36 | TYR | 0.000 | 0.267 | -0.267 | 0.267 |
| 233 | SER | 234 | VAL | 0.266 | 0.000 | 0.266 | 0.266 |
| 344 | PRO | 368 | THR | 2.722 | 2.988 | -0.265 | 0.265 |
| 306 | LEU | 307 | SER | 0.265 | 0.000 | 0.265 | 0.265 |
| 44 | VAL | 76 | LEU | 1.810 | 2.074 | -0.265 | 0.265 |
| 130 | THR | 135 | PRO | 0.429 | 0.166 | 0.263 | 0.263 |
| 219 | ARG | 223 | ILE | 0.869 | 0.607 | 0.262 | 0.262 |
| 326 | LYS | 388 | ILE | 0.000 | 0.260 | -0.260 | 0.260 |
| 185 | ASN | 187 | ASP | 1.463 | 1.203 | 0.260 | 0.260 |
| 17 | ALA | 18 | GLU | 0.259 | 0.000 | 0.259 | 0.259 |
| 89 | LEU | 95 | VAL | 0.627 | 0.885 | -0.258 | 0.258 |
| 80 | THR | 81 | LEU | 0.976 | 1.231 | -0.255 | 0.255 |
| 213 | VAL | 217 | GLN | 1.429 | 1.683 | -0.254 | 0.254 |
| 251 | GLU | 254 | ARG | 0.000 | 0.254 | -0.254 | 0.254 |
| 116 | ALA | 157 | VAL | 1.480 | 1.228 | 0.253 | 0.253 |
| 86 | VAL | 373 | TYR | 1.682 | 1.930 | -0.249 | 0.249 |
| 193 | SER | 350 | VAL | 1.098 | 1.345 | -0.247 | 0.247 |
| 309 | SER | 311 | LYS | 0.000 | 0.241 | -0.241 | 0.241 |
| 337 | ALA | 378 | LEU | 0.000 | 0.239 | -0.239 | 0.239 |
| 104 | ASP | 169 | LEU | 0.814 | 0.576 | 0.238 | 0.238 |
| 338 | PHE | 343 | LEU | 0.377 | 0.143 | 0.234 | 0.234 |
| 103 | CYS | 181 | CYS | 6.688 | 6.455 | 0.233 | 0.233 |
| 54 | VAL | 390 | PHE | 1.471 | 1.238 | 0.232 | 0.232 |
| 293 | LYS | 311 | LYS | 0.000 | 0.231 | -0.231 | 0.231 |
| 106 | PHE | 107 | VAL | 0.566 | 0.796 | -0.230 | 0.230 |
| 173 | ASN | 175 | THR | 0.698 | 0.926 | -0.228 | 0.228 |
| 82 | VAL | 113 | MET | 0.226 | 0.000 | 0.226 | 0.226 |
| 262 | THR | 387 | ASN | 0.226 | 0.000 | 0.226 | 0.226 |
| 192 | SER | 193 | SER | 0.226 | 0.000 | 0.226 | 0.226 |
| 88 | TYR | 92 | THR | 3.181 | 2.957 | 0.224 | 0.224 |
| 208 | TYR | 383 | TYR | 0.223 | 0.000 | 0.223 | 0.223 |
| 225 | THR | 229 | SER | 0.000 | 0.220 | -0.220 | 0.220 |
| 60 | LEU | 389 | GLU | 2.088 | 2.300 | -0.212 | 0.212 |
| 47 | ASN | 379 | ASN | 0.000 | 0.211 | -0.211 | 0.211 |
| 85 | TRP | 102 | CYS | 0.209 | 0.000 | 0.209 | 0.209 |
| 43 | ILE | 79 | ALA | 1.478 | 1.272 | 0.206 | 0.206 |
| 89 | LEU | 94 | GLY | 3.724 | 3.926 | -0.202 | 0.202 |
| 43 | ILE | 47 | ASN | 1.226 | 1.027 | 0.199 | 0.199 |
| 121 | LEU | 204 | THR | 0.213 | 0.411 | -0.199 | 0.199 |
| 350 | VAL | 355 | CYS | 0.327 | 0.131 | 0.196 | 0.196 |
| 115 | THR | 119 | LEU | 1.113 | 0.920 | 0.193 | 0.193 |
| 53 | ALA | 397 | ILE | 1.957 | 1.765 | 0.192 | 0.192 |
| 218 | ARG | 222 | ARG | 0.000 | 0.191 | -0.191 | 0.191 |
| 27 | ARG | 28 | PRO | 0.554 | 0.744 | -0.190 | 0.190 |
| 341 | CYS | 372 | GLY | 2.280 | 2.092 | 0.188 | 0.188 |
| 61 | GLN | 66 | TYR | 2.897 | 2.709 | 0.188 | 0.188 |
| 103 | CYS | 173 | ASN | 0.606 | 0.792 | -0.185 | 0.185 |
| 122 | CYS | 204 | THR | 2.865 | 2.680 | 0.185 | 0.185 |
| 329 | GLN | 333 | ILE | 0.744 | 0.559 | 0.185 | 0.185 |
| 43 | ILE | 75 | ASP | 1.946 | 1.761 | 0.185 | 0.185 |
| 51 | CYS | 73 | VAL | 0.072 | 0.256 | -0.184 | 0.184 |
| 211 | ILE | 215 | LEU | 0.714 | 0.897 | -0.183 | 0.183 |
| 168 | LEU | 183 | ILE | 0.240 | 0.058 | 0.182 | 0.182 |
| 64 | THR | 65 | ASN | 0.303 | 0.120 | 0.182 | 0.182 |
| 369 | THR | 373 | TYR | 1.376 | 1.194 | 0.182 | 0.182 |
| 360 | VAL | 364 | LEU | 0.000 | 0.181 | -0.181 | 0.181 |
| 92 | THR | 97 | ASN | 0.376 | 0.195 | 0.181 | 0.181 |
| 341 | CYS | 368 | THR | 0.114 | 0.294 | -0.180 | 0.180 |
| 118 | ILE | 122 | CYS | 0.000 | 0.180 | -0.180 | 0.180 |
| 154 | ILE | 158 | TRP | 1.079 | 1.258 | -0.179 | 0.179 |
| 189 | VAL | 354 | HIS | 0.309 | 0.132 | 0.177 | 0.177 |
| 196 | SER | 346 | PHE | 0.175 | 0.000 | 0.175 | 0.175 |
| 134 | MET | 218 | ARG | 0.000 | 0.175 | -0.175 | 0.175 |
| 77 | LEU | 82 | VAL | 0.973 | 0.800 | 0.174 | 0.174 |
| 259 | CYS | 260 | GLN | 0.173 | 0.000 | 0.173 | 0.173 |
| 203 | VAL | 207 | VAL | 0.432 | 0.259 | 0.173 | 0.173 |
| 184 | SER | 189 | VAL | 0.173 | 0.000 | 0.173 | 0.173 |
| 86 | VAL | 106 | PHE | 1.155 | 1.327 | -0.172 | 0.172 |
| 378 | LEU | 382 | ILE | 0.422 | 0.251 | 0.171 | 0.171 |
| 244 | SER | 245 | PRO | 0.805 | 0.974 | -0.169 | 0.169 |
| 207 | VAL | 211 | ILE | 0.335 | 0.505 | -0.169 | 0.169 |
| 111 | VAL | 196 | SER | 0.000 | 0.168 | -0.168 | 0.168 |
| 183 | ILE | 349 | HIS | 1.016 | 0.850 | 0.166 | 0.166 |
| 36 | TYR | 87 | VAL | 1.332 | 1.167 | 0.166 | 0.166 |
| 167 | PRO | 188 | PHE | 1.217 | 1.053 | 0.164 | 0.164 |
| 197 | PHE | 338 | PHE | 1.528 | 1.365 | 0.163 | 0.163 |
| 391 | ARG | 395 | LEU | 0.000 | 0.163 | -0.163 | 0.163 |
| 107 | VAL | 181 | CYS | 0.711 | 0.551 | 0.160 | 0.160 |
| 173 | ASN | 184 | SER | 0.000 | 0.160 | -0.160 | 0.160 |
| 116 | ALA | 161 | ALA | 1.740 | 1.899 | -0.159 | 0.159 |
| 201 | PHE | 204 | THR | 0.000 | 0.159 | -0.159 | 0.159 |
| 81 | LEU | 85 | TRP | 0.157 | 0.000 | 0.157 | 0.157 |
| 150 | VAL | 154 | ILE | 0.980 | 0.824 | 0.156 | 0.156 |
| 263 | ALA | 388 | ILE | 0.156 | 0.000 | 0.156 | 0.156 |
| 115 | THR | 165 | SER | 0.000 | 0.155 | -0.155 | 0.155 |
| 53 | ALA | 394 | PHE | 1.384 | 1.228 | 0.155 | 0.155 |
| 127 | ASP | 138 | TYR | 6.833 | 6.680 | 0.153 | 0.153 |
| 198 | TYR | 343 | LEU | 0.149 | 0.000 | 0.149 | 0.149 |
| 185 | ASN | 186 | PRO | 1.593 | 1.445 | 0.149 | 0.149 |
| 115 | THR | 161 | ALA | 2.243 | 2.094 | 0.148 | 0.148 |
| 136 | VAL | 137 | HIS | 0.148 | 0.000 | 0.148 | 0.148 |
| 192 | SER | 197 | PHE | 0.200 | 0.348 | -0.147 | 0.147 |
| 342 | TRP | 346 | PHE | 2.112 | 2.259 | -0.146 | 0.146 |
| 43 | ILE | 373 | TYR | 0.537 | 0.683 | -0.146 | 0.146 |
| 50 | VAL | 68 | VAL | 0.557 | 0.703 | -0.146 | 0.146 |
| 356 | GLN | 357 | THR | 0.145 | 0.000 | 0.145 | 0.145 |
| 48 | GLY | 76 | LEU | 0.915 | 1.059 | -0.145 | 0.145 |
| 61 | GLN | 142 | THR | 0.144 | 0.000 | 0.144 | 0.144 |
| 345 | PHE | 349 | HIS | 0.160 | 0.303 | -0.144 | 0.144 |
| 96 | TRP | 179 | THR | 6.330 | 6.472 | -0.142 | 0.142 |
| 200 | PRO | 338 | PHE | 0.141 | 0.000 | 0.141 | 0.141 |
| 100 | ARG | 103 | CYS | 0.141 | 0.000 | 0.141 | 0.141 |
| 51 | CYS | 72 | ALA | 0.514 | 0.653 | -0.140 | 0.140 |
| 329 | GLN | 386 | PHE | 0.000 | 0.139 | -0.139 | 0.139 |
| 294 | LEU | 295 | SER | 0.139 | 0.000 | 0.139 | 0.139 |
| 219 | ARG | 321 | PRO | 0.138 | 0.000 | 0.138 | 0.138 |
| 368 | THR | 369 | THR | 0.037 | 0.174 | -0.136 | 0.136 |
| 60 | LEU | 65 | ASN | 6.172 | 6.307 | -0.135 | 0.135 |
| 54 | VAL | 69 | VAL | 1.908 | 2.041 | -0.134 | 0.134 |
| 374 | VAL | 378 | LEU | 0.926 | 0.792 | 0.134 | 0.134 |
| 261 | ASP | 388 | ILE | 0.133 | 0.000 | 0.133 | 0.133 |
| 77 | LEU | 81 | LEU | 0.963 | 0.830 | 0.132 | 0.132 |
| 39 | LEU | 374 | VAL | 2.029 | 2.158 | -0.129 | 0.129 |
| 321 | PRO | 323 | ARG | 0.000 | 0.128 | -0.128 | 0.128 |
| 146 | SER | 149 | ARG | 0.317 | 0.443 | -0.126 | 0.126 |
| 128 | ARG | 327 | ALA | 0.000 | 0.126 | -0.126 | 0.126 |
| 155 | THR | 159 | VAL | 0.478 | 0.357 | 0.121 | 0.121 |
| 67 | LEU | 153 | MET | 0.818 | 0.937 | -0.118 | 0.118 |
| 50 | VAL | 390 | PHE | 0.592 | 0.475 | 0.117 | 0.117 |
| 219 | ARG | 319 | GLY | 0.114 | 0.000 | 0.114 | 0.114 |
| 183 | ILE | 188 | PHE | 1.319 | 1.206 | 0.113 | 0.113 |
| 47 | ASN | 50 | VAL | 0.000 | 0.112 | -0.112 | 0.112 |
| 78 | VAL | 373 | TYR | 1.200 | 1.312 | -0.112 | 0.112 |
| 3 | SER | 5 | SER | 0.000 | 0.112 | -0.112 | 0.112 |
| 382 | ILE | 387 | ASN | 0.000 | 0.110 | -0.110 | 0.110 |
| 126 | ILE | 130 | THR | 0.096 | 0.206 | -0.110 | 0.110 |
| 82 | VAL | 109 | LEU | 1.312 | 1.421 | -0.109 | 0.109 |
| 53 | ALA | 390 | PHE | 0.424 | 0.532 | -0.107 | 0.107 |
| 344 | PRO | 371 | LEU | 0.337 | 0.444 | -0.106 | 0.106 |
| 122 | CYS | 125 | SER | 0.106 | 0.000 | 0.106 | 0.106 |
| 312 | LEU | 315 | LEU | 0.106 | 0.000 | 0.106 | 0.106 |
| 19 | ASN | 20 | SER | 0.000 | 0.105 | -0.105 | 0.105 |
| 190 | ILE | 194 | VAL | 0.185 | 0.289 | -0.104 | 0.104 |
| 67 | LEU | 120 | ASN | 0.601 | 0.705 | -0.104 | 0.104 |
| 67 | LEU | 123 | ALA | 1.276 | 1.380 | -0.103 | 0.103 |
| 119 | LEU | 195 | VAL | 0.101 | 0.000 | 0.101 | 0.101 |
| 36 | TYR | 366 | SER | 0.607 | 0.507 | 0.100 | 0.100 |
| 173 | ASN | 183 | ILE | 0.502 | 0.403 | 0.099 | 0.099 |
| 129 | TYR | 130 | THR | 0.000 | 0.097 | -0.097 | 0.097 |
| 51 | CYS | 76 | LEU | 0.520 | 0.423 | 0.097 | 0.097 |
| 23 | ALA | 27 | ARG | 0.000 | 0.097 | -0.097 | 0.097 |
| 73 | VAL | 158 | TRP | 0.358 | 0.262 | 0.096 | 0.096 |
| 108 | THR | 169 | LEU | 4.931 | 4.834 | 0.096 | 0.096 |
| 193 | SER | 198 | TYR | 5.638 | 5.733 | -0.095 | 0.095 |
| 255 | TYR | 259 | CYS | 0.000 | 0.095 | -0.095 | 0.095 |
| 208 | TYR | 211 | ILE | 0.697 | 0.604 | 0.093 | 0.093 |
| 28 | PRO | 32 | TYR | 0.092 | 0.000 | 0.092 | 0.092 |
| 101 | ILE | 105 | VAL | 0.000 | 0.092 | -0.092 | 0.092 |
| 126 | ILE | 207 | VAL | 0.565 | 0.473 | 0.092 | 0.092 |
| 379 | ASN | 380 | PRO | 0.947 | 1.038 | -0.092 | 0.092 |
| 339 | ILE | 343 | LEU | 0.584 | 0.493 | 0.091 | 0.091 |
| 132 | VAL | 133 | VAL | 0.090 | 0.000 | 0.090 | 0.090 |
| 341 | CYS | 374 | VAL | 0.090 | 0.000 | 0.090 | 0.090 |
| 384 | THR | 385 | THR | 0.357 | 0.268 | 0.089 | 0.089 |
| 164 | VAL | 195 | VAL | 1.320 | 1.408 | -0.088 | 0.088 |
| 100 | ARG | 179 | THR | 0.000 | 0.088 | -0.088 | 0.088 |
| 126 | ILE | 203 | VAL | 0.087 | 0.000 | 0.087 | 0.087 |
| 116 | ALA | 120 | ASN | 0.117 | 0.203 | -0.086 | 0.086 |
| 169 | LEU | 170 | PHE | 0.086 | 0.000 | 0.086 | 0.086 |
| 254 | ARG | 258 | ILE | 0.000 | 0.085 | -0.085 | 0.085 |
| 287 | SER | 288 | PRO | 0.625 | 0.708 | -0.083 | 0.083 |
| 39 | LEU | 377 | ALA | 0.770 | 0.689 | 0.081 | 0.081 |
| 125 | SER | 211 | ILE | 0.450 | 0.530 | -0.080 | 0.080 |
| 78 | VAL | 84 | PRO | 0.060 | 0.139 | -0.079 | 0.079 |
| 357 | THR | 358 | CYS | 0.000 | 0.079 | -0.079 | 0.079 |
| 364 | LEU | 368 | THR | 0.442 | 0.363 | 0.078 | 0.078 |
| 40 | ILE | 44 | VAL | 0.226 | 0.149 | 0.078 | 0.078 |
| 28 | PRO | 29 | HIS | 0.078 | 0.155 | -0.077 | 0.077 |
| 109 | LEU | 113 | MET | 0.475 | 0.399 | 0.076 | 0.076 |
| 106 | PHE | 181 | CYS | 0.776 | 0.851 | -0.075 | 0.075 |
| 78 | VAL | 82 | VAL | 0.018 | 0.090 | -0.073 | 0.073 |
| 162 | PHE | 165 | SER | 0.072 | 0.000 | 0.072 | 0.072 |
| 77 | LEU | 113 | MET | 2.777 | 2.705 | 0.072 | 0.072 |
| 164 | VAL | 165 | SER | 0.000 | 0.072 | -0.072 | 0.072 |
| 194 | VAL | 198 | TYR | 0.250 | 0.179 | 0.071 | 0.071 |
| 194 | VAL | 200 | PRO | 0.446 | 0.516 | -0.070 | 0.070 |
| 215 | LEU | 327 | ALA | 0.070 | 0.000 | 0.070 | 0.070 |
| 43 | ILE | 76 | LEU | 0.228 | 0.297 | -0.069 | 0.069 |
| 39 | LEU | 370 | TRP | 0.514 | 0.446 | 0.069 | 0.069 |
| 69 | VAL | 73 | VAL | 0.253 | 0.185 | 0.068 | 0.068 |
| 58 | ARG | 61 | GLN | 0.520 | 0.587 | -0.067 | 0.067 |
| 222 | ARG | 226 | ARG | 0.065 | 0.000 | 0.065 | 0.065 |
| 343 | LEU | 344 | PRO | 0.880 | 0.946 | -0.065 | 0.065 |
| 326 | LYS | 330 | MET | 0.065 | 0.000 | 0.065 | 0.065 |
| 103 | CYS | 182 | SER | 0.058 | 0.123 | -0.065 | 0.065 |
| 96 | TRP | 178 | PRO | 0.866 | 0.930 | -0.064 | 0.064 |
| 33 | ALA | 91 | VAL | 0.706 | 0.642 | 0.063 | 0.063 |
| 330 | MET | 390 | PHE | 0.000 | 0.063 | -0.063 | 0.063 |
| 256 | TYR | 261 | ASP | 0.062 | 0.000 | 0.062 | 0.062 |
| 177 | ASP | 178 | PRO | 2.661 | 2.723 | -0.062 | 0.062 |
| 129 | TYR | 134 | MET | 0.147 | 0.086 | 0.062 | 0.062 |
| 121 | LEU | 124 | ILE | 0.000 | 0.061 | -0.061 | 0.061 |
| 194 | VAL | 199 | LEU | 3.204 | 3.265 | -0.061 | 0.061 |
| 107 | VAL | 183 | ILE | 1.589 | 1.650 | -0.061 | 0.061 |
| 79 | ALA | 83 | MET | 0.272 | 0.212 | 0.060 | 0.060 |
| 226 | ARG | 229 | SER | 0.059 | 0.000 | 0.059 | 0.059 |
| 78 | VAL | 83 | MET | 4.762 | 4.821 | -0.059 | 0.059 |
| 60 | LEU | 393 | ALA | 0.710 | 0.652 | 0.059 | 0.059 |
| 32 | TYR | 363 | GLU | 0.118 | 0.175 | -0.058 | 0.058 |
| 89 | LEU | 92 | THR | 0.075 | 0.132 | -0.056 | 0.056 |
| 43 | ILE | 83 | MET | 1.238 | 1.182 | 0.056 | 0.056 |
| 50 | VAL | 72 | ALA | 0.770 | 0.826 | -0.056 | 0.056 |
| 252 | LEU | 256 | TYR | 0.000 | 0.055 | -0.055 | 0.055 |
| 77 | LEU | 158 | TRP | 0.744 | 0.800 | -0.055 | 0.055 |
| 75 | ASP | 380 | PRO | 0.055 | 0.000 | 0.055 | 0.055 |
| 204 | THR | 205 | VAL | 0.000 | 0.055 | -0.055 | 0.055 |
| 379 | ASN | 384 | THR | 0.055 | 0.000 | 0.055 | 0.055 |
| 68 | VAL | 390 | PHE | 0.087 | 0.142 | -0.054 | 0.054 |
| 89 | LEU | 181 | CYS | 0.198 | 0.144 | 0.053 | 0.053 |
| 120 | ASN | 158 | TRP | 0.053 | 0.000 | 0.053 | 0.053 |
| 162 | PHE | 169 | LEU | 0.000 | 0.052 | -0.052 | 0.052 |
| 100 | ARG | 104 | ASP | 0.000 | 0.052 | -0.052 | 0.052 |
| 231 | CYS | 232 | ASN | 0.000 | 0.051 | -0.051 | 0.051 |
| 345 | PHE | 368 | THR | 4.428 | 4.479 | -0.051 | 0.051 |
| 36 | TYR | 83 | MET | 1.302 | 1.253 | 0.050 | 0.050 |
| 42 | ALA | 377 | ALA | 0.033 | 0.083 | -0.049 | 0.049 |
| 87 | VAL | 91 | VAL | 0.210 | 0.162 | 0.048 | 0.048 |
| 65 | ASN | 68 | VAL | 0.000 | 0.045 | -0.045 | 0.045 |
| 355 | CYS | 358 | CYS | 3.749 | 3.792 | -0.044 | 0.044 |
| 322 | LEU | 326 | LYS | 0.000 | 0.043 | -0.043 | 0.043 |
| 183 | ILE | 353 | THR | 0.018 | 0.061 | -0.043 | 0.043 |
| 117 | SER | 376 | SER | 0.042 | 0.000 | 0.042 | 0.042 |
| 44 | VAL | 80 | THR | 0.198 | 0.158 | 0.040 | 0.040 |
| 39 | LEU | 43 | ILE | 1.352 | 1.313 | 0.039 | 0.039 |
| 383 | TYR | 384 | THR | 0.039 | 0.000 | 0.039 | 0.039 |
| 229 | SER | 230 | GLN | 0.039 | 0.000 | 0.039 | 0.039 |
| 121 | LEU | 342 | TRP | 0.038 | 0.000 | 0.038 | 0.038 |
| 212 | TYR | 213 | VAL | 0.038 | 0.000 | 0.038 | 0.038 |
| 139 | GLN | 258 | ILE | 0.038 | 0.000 | 0.038 | 0.038 |
| 132 | VAL | 211 | ILE | 0.478 | 0.441 | 0.038 | 0.038 |
| 370 | TRP | 371 | LEU | 0.115 | 0.078 | 0.037 | 0.037 |
| 82 | VAL | 373 | TYR | 1.185 | 1.222 | -0.037 | 0.037 |
| 100 | ARG | 177 | ASP | 5.690 | 5.727 | -0.037 | 0.037 |
| 348 | THR | 360 | VAL | 0.601 | 0.638 | -0.037 | 0.037 |
| 182 | SER | 184 | SER | 0.075 | 0.039 | 0.036 | 0.036 |
| 348 | THR | 368 | THR | 3.397 | 3.363 | 0.034 | 0.034 |
| 280 | GLU | 281 | LYS | 0.000 | 0.034 | -0.034 | 0.034 |
| 92 | THR | 95 | VAL | 0.524 | 0.490 | 0.034 | 0.034 |
| 341 | CYS | 342 | TRP | 0.329 | 0.295 | 0.034 | 0.034 |
| 36 | TYR | 39 | LEU | 0.085 | 0.052 | 0.033 | 0.033 |
| 86 | VAL | 90 | GLU | 0.000 | 0.032 | -0.032 | 0.032 |
| 157 | VAL | 158 | TRP | 0.031 | 0.000 | 0.031 | 0.031 |
| 136 | VAL | 139 | GLN | 0.031 | 0.000 | 0.031 | 0.031 |
| 108 | THR | 166 | CYS | 0.030 | 0.000 | 0.030 | 0.030 |
| 73 | VAL | 77 | LEU | 0.550 | 0.521 | 0.030 | 0.030 |
| 44 | VAL | 79 | ALA | 0.660 | 0.689 | -0.028 | 0.028 |
| 79 | ALA | 84 | PRO | 1.889 | 1.917 | -0.028 | 0.028 |
| 178 | PRO | 179 | THR | 0.000 | 0.028 | -0.028 | 0.028 |
| 189 | VAL | 350 | VAL | 0.192 | 0.220 | -0.028 | 0.028 |
| 342 | TRP | 373 | TYR | 0.000 | 0.027 | -0.027 | 0.027 |
| 36 | TYR | 369 | THR | 1.049 | 1.076 | -0.027 | 0.027 |
| 103 | CYS | 107 | VAL | 0.368 | 0.395 | -0.027 | 0.027 |
| 110 | ASP | 115 | THR | 0.027 | 0.000 | 0.027 | 0.027 |
| 111 | VAL | 115 | THR | 0.500 | 0.476 | 0.024 | 0.024 |
| 52 | MET | 397 | ILE | 1.368 | 1.344 | 0.023 | 0.023 |
| 270 | GLN | 271 | GLU | 0.000 | 0.021 | -0.021 | 0.021 |
| 189 | VAL | 193 | SER | 0.345 | 0.366 | -0.021 | 0.021 |
| 44 | VAL | 49 | LEU | 0.021 | 0.000 | 0.021 | 0.021 |
| 55 | LEU | 61 | GLN | 1.620 | 1.640 | -0.020 | 0.020 |
| 376 | SER | 379 | ASN | 0.019 | 0.000 | 0.019 | 0.019 |
| 198 | TYR | 347 | LEU | 1.538 | 1.557 | -0.019 | 0.019 |
| 129 | TYR | 207 | VAL | 1.538 | 1.520 | 0.018 | 0.018 |
| 94 | GLY | 179 | THR | 0.717 | 0.700 | 0.017 | 0.017 |
| 64 | THR | 141 | GLY | 0.017 | 0.000 | 0.017 | 0.017 |
| 119 | LEU | 157 | VAL | 4.421 | 4.438 | -0.017 | 0.017 |
| 43 | ILE | 48 | GLY | 0.189 | 0.206 | -0.016 | 0.016 |
| 83 | MET | 84 | PRO | 0.704 | 0.689 | 0.016 | 0.016 |
| 330 | MET | 382 | ILE | 0.660 | 0.644 | 0.016 | 0.016 |
| 53 | ALA | 393 | ALA | 0.689 | 0.704 | -0.015 | 0.015 |
| 199 | LEU | 203 | VAL | 0.156 | 0.170 | -0.014 | 0.014 |
| 36 | TYR | 373 | TYR | 0.909 | 0.924 | -0.014 | 0.014 |
| 123 | ALA | 157 | VAL | 0.503 | 0.490 | 0.013 | 0.013 |
| 222 | ARG | 225 | THR | 0.013 | 0.000 | 0.013 | 0.013 |
| 188 | PHE | 193 | SER | 0.028 | 0.040 | -0.011 | 0.011 |
| 111 | VAL | 188 | PHE | 0.010 | 0.000 | 0.010 | 0.010 |
| 105 | VAL | 109 | LEU | 0.762 | 0.753 | 0.010 | 0.010 |
| 40 | ILE | 87 | VAL | 0.497 | 0.506 | -0.009 | 0.009 |
| 77 | LEU | 80 | THR | 0.166 | 0.174 | -0.009 | 0.009 |
| 103 | CYS | 104 | ASP | 0.000 | 0.009 | -0.009 | 0.009 |
| 341 | CYS | 378 | LEU | 0.531 | 0.540 | -0.008 | 0.008 |
| 42 | ALA | 47 | ASN | 0.000 | 0.007 | -0.007 | 0.007 |
| 235 | ARG | 236 | PRO | 0.294 | 0.287 | 0.007 | 0.007 |
| 63 | THR | 128 | ARG | 0.000 | 0.006 | -0.006 | 0.006 |
| 39 | LEU | 373 | TYR | 1.510 | 1.515 | -0.005 | 0.005 |
| 224 | LEU | 227 | GLN | 0.391 | 0.390 | 0.001 | 0.001 |
| 134 | MET | 135 | PRO | 0.098 | 0.099 | -0.001 | 0.001 |
| 82 | VAL | 86 | VAL | 0.262 | 0.263 | -0.001 | 0.001 |
| 179 | THR | 180 | VAL | 0.433 | 0.433 | -0.000 | 0.000 |
RRCS change distribution
0.13
Mean ΔRRCS
1.83
Std Dev
0.04
Median
Magnitude classification
21
High (|Δ| ≥ 5.0)
49
Medium (2.5 ≤ |Δ| < 5.0)
672
Low (|Δ| < 2.5)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.54, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar