EDNRB
802
Total Contact Pairs
79
Significant Changes
6.31
Max Increase
-19.11
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | GLN41 | ILE94 (1.25x25) | 0.000 | 19.115 | -19.115 | HIGH |
| 2 | ARG343 (6.55x55) | ASP368 (7.35x34) | 0.109 | 9.910 | -9.801 | HIGH |
| 3 | SER399 (8.56x56) | GLN406 | 0.000 | 9.393 | -9.393 | HIGH |
| 4 | PRO38 | GLU165 | 0.000 | 8.706 | -8.706 | HIGH |
| 5 | PRO3 | TYR102 (1.33x33) | 0.000 | 8.620 | -8.620 | HIGH |
| 6 | TYR293 (5.58x58) | PHE326 (6.38x38) | 0.760 | 8.484 | -7.724 | HIGH |
| 7 | ARG201 (3.52x52) | ARG208 (34.52x52) | 0.000 | 6.633 | -6.633 | HIGH |
| 8 | TYR430 | ASP431 | 6.314 | 0.000 | +6.314 | HIGH |
| 9 | ALA43 | LEU256 (45.51x51) | 0.000 | 6.104 | -6.104 | HIGH |
| 10 | TYR293 (5.58x58) | VAL325 (6.37x37) | 6.003 | 0.000 | +6.003 | HIGH |
| 11 | GLN261 | GLN267 (5.32x33) | 5.067 | 10.908 | -5.841 | HIGH |
| 12 | TYR127 (1.58x58) | ARG133 (12.51x51) | 0.111 | 5.942 | -5.831 | HIGH |
| 13 | TRP404 | PHE408 | 5.757 | 0.000 | +5.757 | HIGH |
| 14 | MET300 (5.65x65) | ARG318 (6.30x30) | 5.691 | 0.120 | +5.572 | HIGH |
| 15 | ARG199 (3.50x50) | TYR293 (5.58x58) | 5.441 | 0.000 | +5.441 | HIGH |
| 16 | LEU39 | TYR247 | 0.000 | 5.058 | -5.058 | HIGH |
| 17 | CYS8 | CYS109 (1.40x40) | 0.000 | 5.026 | -5.026 | HIGH |
| 18 | GLU299 (5.64x64) | LYS303 (5.68x68) | 0.000 | 4.881 | -4.881 | MED |
| 19 | SER196 (3.47x47) | TYR293 (5.58x58) | 4.631 | 0.000 | +4.631 | MED |
| 20 | LYS175 (3.26x26) | ASP241 | 0.037 | 4.629 | -4.592 | MED |
| 21 | PRO4 | TYR102 (1.33x33) | 0.000 | 4.590 | -4.590 | MED |
| 22 | SER342 (6.54x54) | LEU367 (7.34x33) | 2.246 | 6.654 | -4.408 | MED |
| 23 | TRP167 (23.50x50) | CYS255 (45.50x50) | 2.367 | 6.761 | -4.394 | MED |
| 24 | ASP166 (23.49x49) | ARG253 | 7.370 | 3.025 | +4.345 | MED |
| 25 | PHE326 (6.38x38) | LEU330 (6.42x42) | 0.000 | 4.294 | -4.294 | MED |
| 26 | THR47 | LYS270 (5.35x36) | 0.000 | 4.269 | -4.269 | MED |
| 27 | ASP147 (2.50x50) | THR188 (3.39x39) | 4.570 | 0.542 | +4.028 | MED |
| 28 | TRP206 (34.50x50) | LYS303 (5.68x68) | 0.000 | 3.782 | -3.782 | MED |
| 29 | LYS398 (8.55x55) | GLU409 | 0.000 | 3.582 | -3.582 | MED |
| 30 | LEU12 | PHE112 (1.43x43) | 0.000 | 3.569 | -3.569 | MED |
| 31 | ASP198 (3.49x49) | ARG199 (3.50x50) | 0.000 | 3.531 | -3.531 | MED |
| 32 | GLU27 | ARG29 | 0.000 | 3.520 | -3.520 | MED |
| 33 | PRO136 (2.39x39) | ARG199 (3.50x50) | 0.000 | 3.485 | -3.485 | MED |
| 34 | ILE94 (1.25x25) | SER362 (7.29x28) | 1.601 | 5.048 | -3.447 | MED |
| 35 | PHE240 (4.64x65) | LEU257 (45.52x52) | 5.054 | 8.458 | -3.404 | MED |
| 36 | ALA43 | ILE254 | 0.000 | 3.379 | -3.379 | MED |
| 37 | TRP206 (34.50x50) | LEU311 | 0.000 | 3.362 | -3.362 | MED |
| 38 | ARG199 (3.50x50) | VAL321 (6.33x33) | 0.000 | 3.337 | -3.337 | MED |
| 39 | LEU39 | GLU165 | 0.000 | 3.249 | -3.249 | MED |
| 40 | GLN352 | ARG357 (7.24x23) | 1.685 | 4.889 | -3.204 | MED |
| 41 | GLU44 | VAL260 | 3.121 | 0.000 | +3.121 | MED |
| 42 | ARG124 (1.55x55) | LYS128 (1.59x59) | 0.000 | 3.055 | -3.055 | MED |
| 43 | TRP25 | LYS97 (1.28x28) | 3.048 | 0.000 | +3.048 | MED |
| 44 | LEU40 | GLN41 | 3.044 | 0.000 | +3.044 | MED |
| 45 | ILE94 (1.25x25) | LEU361 (7.28x27) | 0.779 | 3.818 | -3.039 | MED |
| 46 | PHE332 (6.44x44) | TRP336 (6.48x48) | 4.334 | 7.365 | -3.031 | MED |
| 47 | LEU149 (2.52x52) | SER184 (3.35x35) | 4.266 | 1.247 | +3.019 | MED |
| 48 | CYS90 | ARG357 (7.24x23) | 6.543 | 3.587 | +2.956 | MED |
| 49 | PHE112 (1.43x43) | ILE116 | 3.706 | 0.793 | +2.914 | MED |
| 50 | TYR350 | ARG357 (7.24x23) | 0.348 | 3.219 | -2.871 | MED |
| 51 | TYR269 | LYS273 | 0.133 | 3.001 | -2.868 | MED |
| 52 | ARG201 (3.52x52) | ILE209 | 2.867 | 0.000 | +2.867 | MED |
| 53 | SER58 | ASN59 | 2.806 | 0.000 | +2.806 | MED |
| 54 | ILE94 (1.25x25) | CYS358 | 2.882 | 5.686 | -2.804 | MED |
| 55 | PHE240 (4.64x65) | LEU256 (45.51x51) | 6.018 | 8.815 | -2.797 | MED |
| 56 | GLN91 | PRO355 | 0.838 | 3.593 | -2.755 | MED |
| 57 | TYR247 | LYS248 | 5.208 | 7.960 | -2.752 | MED |
| 58 | THR297 | PHE326 (6.38x38) | 2.723 | 0.000 | +2.723 | MED |
| 59 | LEU12 | PRO156 | 0.000 | 2.668 | -2.668 | MED |
| 60 | ASN104 | ASN373 | 4.523 | 7.172 | -2.649 | MED |
| 61 | ALA202 | ILE209 | 2.639 | 0.000 | +2.639 | MED |
| 62 | VAL71 | PRO72 | 1.239 | 3.861 | -2.622 | MED |
| 63 | MET296 | ALA322 | 0.000 | 2.612 | -2.612 | MED |
| 64 | VAL16 | PRO156 | 0.000 | 2.605 | -2.605 | MED |
| 65 | GLU44 | LYS346 | 0.000 | 2.564 | -2.564 | MED |
| 66 | THR324 | VAL389 | 2.511 | 5.038 | -2.527 | MED |
| 67 | SER436 | ASN437 | 2.516 | 0.000 | +2.516 | MED |
| 68 | TRP276 | PHE280 | 5.282 | 7.762 | -2.480 | MED |
| 69 | TRP167 (23.50x50) | PHE169 | 2.592 | 5.061 | -2.469 | MED |
| 70 | VAL185 | TRP336 (6.48x48) | 2.906 | 5.350 | -2.444 | MED |
| 71 | ALA202 | ARG318 (6.30x30) | 0.000 | 2.436 | -2.436 | MED |
| 72 | THR294 | PHE326 (6.38x38) | 2.340 | 0.000 | +2.340 | MED |
| 73 | GLU44 | PRO259 | 2.336 | 0.000 | +2.336 | MED |
| 74 | LEU339 | ARG343 (6.55x55) | 2.734 | 0.406 | +2.328 | MED |
| 75 | ASP198 (3.49x49) | LYS210 | 0.000 | 2.315 | -2.315 | MED |
| 76 | LEU339 | GLY371 | 2.192 | 4.496 | -2.304 | MED |
| 77 | TYR293 (5.58x58) | THR297 | 0.000 | 2.286 | -2.286 | MED |
| 78 | PRO5 | TYR102 (1.33x33) | 0.000 | 2.282 | -2.282 | MED |
| 79 | ILE243 | HIS258 | 1.255 | 3.538 | -2.282 | MED |
| 80 | LEU252 | ILE254 | 0.189 | 2.387 | -2.198 | LOW |
| 81 | LEU232 | TYR281 | 0.000 | 2.197 | -2.197 | LOW |
| 82 | CYS8 | LEU388 | 2.189 | 0.000 | +2.189 | LOW |
| 83 | PRO5 | ARG10 | 2.343 | 0.167 | +2.175 | LOW |
| 84 | ILE157 | PHE169 | 0.000 | 2.171 | -2.171 | LOW |
| 85 | THR289 | VAL329 | 1.317 | 3.477 | -2.161 | LOW |
| 86 | PHE282 | LEU286 | 0.843 | 2.991 | -2.147 | LOW |
| 87 | SER342 (6.54x54) | ASP368 (7.35x34) | 4.369 | 6.514 | -2.144 | LOW |
| 88 | CYS131 | ARG392 | 4.898 | 7.022 | -2.123 | LOW |
| 89 | PRO235 | TYR269 | 4.504 | 6.617 | -2.113 | LOW |
| 90 | ARG124 (1.55x55) | CYS400 | 0.011 | 2.094 | -2.083 | LOW |
| 91 | TRP54 | PRO55 | 2.431 | 0.352 | +2.080 | LOW |
| 92 | SER196 (3.47x47) | VAL325 (6.37x37) | 0.000 | 2.021 | -2.021 | LOW |
| 93 | VAL203 | ARG318 (6.30x30) | 0.000 | 2.000 | -2.000 | LOW |
| 94 | VAL203 | MET300 (5.65x65) | 2.945 | 0.957 | +1.987 | LOW |
| 95 | ILE238 | MET266 | 0.000 | 1.982 | -1.982 | LOW |
| 96 | TYR387 | LYS394 | 6.462 | 8.410 | -1.948 | LOW |
| 97 | PRO168 | PHE169 | 1.796 | 3.738 | -1.942 | LOW |
| 98 | PRO48 | GLN352 | 0.000 | 1.930 | -1.930 | LOW |
| 99 | THR42 | TYR247 | 0.000 | 1.927 | -1.927 | LOW |
| 100 | PRO136 (2.39x39) | LEU195 | 0.000 | 1.887 | -1.887 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.26 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 94-128 | 97 (3.0) | 1 | 94 (-19.1), 102 (-8.6), 127 (-5.8), 109 (-5.0), 112 (-3.6), 124 (-3.1), 128 (-3.1) | 7 |
| TM2 | 136-149 | 147 (4.0), 149 (3.0) | 2 | 136 (-3.5) | 1 |
| TM3 | 175-201 | 199 (5.4), 196 (4.6), 188 (4.0), 184 (3.0) | 4 | 201 (-6.6), 175 (-4.6), 198 (-3.5) | 3 |
| TM4 | 240-240 | - | 0 | 240 (-3.4) | 1 |
| TM5 | 267-303 | 300 (5.6) | 1 | 293 (-7.7), 267 (-5.8), 299 (-4.9), 303 (-4.9), 270 (-4.3) | 5 |
| TM6 | 318-343 | 325 (6.0), 318 (5.6) | 2 | 343 (-9.8), 326 (-7.7), 342 (-4.4), 330 (-4.3), 321 (-3.3), 332 (-3.0), 336 (-3.0) | 7 |
| TM7 | 357-368 | - | 0 | 368 (-9.8), 367 (-4.4), 362 (-3.4), 357 (-3.2), 361 (-3.0) | 5 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 133-133 | - | 0 | 133 (-5.8) | 1 |
| ICL2 | 206-208 | - | 0 | 208 (-6.6), 206 (-3.8) | 2 |
| ICL3 | 311-311 | - | 0 | 311 (-3.4) | 1 |
| ECL1 | 165-167 | 166 (4.3) | 1 | 165 (-8.7), 167 (-4.4) | 2 |
| ECL2 | 241-261 | 253 (4.3), 260 (3.1) | 2 | 256 (-6.1), 261 (-5.8), 247 (-5.1), 241 (-4.6), 255 (-4.4), 257 (-3.4), 254 (-3.4) | 7 |
| ECL3 | 352-352 | - | 0 | 352 (-3.2) | 1 |
| H8 | 398-399 | - | 0 | 399 (-9.4), 398 (-3.6) | 2 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
111 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 41 | p.Cys41Phe | c.122G>T | 6.85e-07 | 1 / 0 | 19.11 | 0.277 | BENIGN | 0.49 | |
| 94 | p.Ile94Met | c.282C>G | 6.84e-07 | 1 / 0 | 19.11 | 0.084 | BENIGN | 0.57 | |
| 94 | p.Ile94Ser | c.281T>G | 6.88e-07 | 1 / 0 | 19.11 | - | nan | - | rs1235006032 |
| 94 | p.Ile94Val | c.280A>G | 6.85e-07 | 1 / 0 | 19.11 | - | nan | - | rs772055405 |
| 41 | p.Cys41Ser | c.121T>A | 1.37e-06 | 2 / 0 | 19.11 | - | nan | - | |
| 41 | p.Cys41Arg | c.121T>C | 6.85e-07 | 1 / 0 | 19.11 | - | nan | - | rs1211498023 |
| 343 | p.Arg343Gly | c.1027A>G | 6.85e-07 | 1 / 0 | 9.80 | 0.925 | PATHOGENIC | 0.91 | |
| 399 | p.Ala399Gly | c.1196C>G | 7.13e-07 | 1 / 0 | 9.39 | 0.238 | BENIGN | 0.73 | |
| 406 | p.Lys406Arg | c.1217A>G | 7.06e-07 | 1 / 0 | 9.39 | 0.082 | BENIGN | 0.46 | rs199973193 |
| 406 | p.Lys406Met | c.1217A>T | 6.57e-06 | 1 / 0 | 9.39 | - | nan | - | rs199973193 |
| 399 | p.Ala399Val | c.1196C>T | 7.13e-07 | 1 / 0 | 9.39 | - | nan | - | rs1439193162 |
| 406 | p.Gln406Leu | c.1217A>T | 1.37e-06 | 2 / 0 | 9.39 | - | nan | - | |
| 399 | p.Ser399Pro | c.1195T>C | 6.58e-06 | 1 / 0 | 9.39 | - | nan | - | rs750260325 |
| 399 | p.Ser399Thr | c.1195T>A | 8.91e-06 | 9 / 2 | 9.39 | - | nan | - | rs750260325 |
| 165 | p.Glu165Asp | c.495G>C | 6.85e-07 | 1 / 0 | 8.71 | 0.250 | BENIGN | 0.44 | |
| 38 | p.Pro38Arg | c.113C>G | 7.10e-07 | 1 / 0 | 8.71 | 0.086 | BENIGN | 0.66 | |
| 38 | p.Pro38Leu | c.113C>T | 2.13e-06 | 3 / 0 | 8.71 | - | nan | - | rs779495524 |
| 102 | p.Tyr102Cys | c.305A>G | 6.84e-07 | 1 / 0 | 8.62 | 0.264 | BENIGN | 0.96 | |
| 3 | p.Pro3Leu | c.8C>T | 4.43e-05 | 64 / 0 | 8.62 | 0.084 | BENIGN | 0.85 | rs200047993 |
| 3 | p.Pro3Gln | c.8C>A | 6.92e-07 | 1 / 0 | 8.62 | - | nan | - | |
| 3 | p.Lys3Arg | c.8A>G | 6.88e-07 | 1 / 0 | 8.62 | - | nan | - | rs1880008161 |
| 293 | p.Tyr293His | c.877T>C | 6.85e-07 | 1 / 0 | 7.72 | 0.992 | PATHOGENIC | 0.92 | rs1352720092 |
| 208 | p.Arg208Lys | c.623G>A | 1.37e-06 | 2 / 0 | 6.63 | 0.412 | AMBIGUOUS | 0.86 | rs1361744218 |
| 201 | p.Arg201Gln | c.602G>A | 1.64e-05 | 24 / 0 | 6.63 | 0.365 | AMBIGUOUS | 0.85 | rs780841273 |
| 201 | p.Arg201Leu | c.602G>T | 6.85e-07 | 1 / 0 | 6.63 | - | nan | - | |
| 431 | p.Arg431Ile | c.1292G>T | 7.04e-07 | 1 / 0 | 6.31 | 0.559 | AMBIGUOUS | 0.78 | |
| 430 | p.Glu430Lys | c.1288G>A | 7.03e-07 | 1 / 0 | 6.31 | 0.456 | AMBIGUOUS | 0.52 | |
| 431 | p.Arg431Gly | c.1291A>G | 7.04e-07 | 1 / 0 | 6.31 | - | nan | - | rs200248884 |
| 430 | p.Tyr430Cys | c.1289A>G | 6.85e-07 | 1 / 0 | 6.31 | - | nan | - | |
| 430 | p.Tyr430Phe | c.1289A>T | 6.58e-06 | 1 / 0 | 6.31 | - | nan | - | rs1878736000 |
| 430 | p.Tyr430His | c.1288T>C | 1.31e-05 | 2 / 0 | 6.31 | - | nan | - | rs568662694 |
| 43 | p.Ala43Thr | c.127G>A | 7.09e-07 | 1 / 0 | 6.10 | 0.066 | BENIGN | 0.45 | rs200304077 |
| 43 | p.Ala43Ser | c.127G>T | 3.54e-06 | 5 / 0 | 6.10 | - | nan | - | rs200304077 |
| 43 | p.Ser43Cys | c.128C>G | 8.90e-06 | 13 / 0 | 6.10 | - | nan | - | rs578207213 |
| 43 | p.Ser43Pro | c.127T>C | 6.85e-07 | 1 / 0 | 6.10 | - | nan | - | rs1451648041 |
| 325 | p.Val325Ile | c.973G>A | 2.05e-05 | 28 / 1 | 6.00 | 0.530 | AMBIGUOUS | 0.95 | rs201437745 |
| 261 | p.Gln261Arg | c.782A>G | 6.85e-07 | 1 / 0 | 5.84 | 0.560 | AMBIGUOUS | 0.37 | |
| 267 | p.Gln267Glu | c.799C>G | 6.85e-07 | 1 / 0 | 5.84 | 0.075 | BENIGN | 0.41 | |
| 404 | p.Lys404Arg | c.1211A>G | 1.11e-05 | 16 / 0 | 5.76 | 0.764 | PATHOGENIC | 0.63 | rs749769388 |
| 408 | p.Val408Leu | c.1222G>C | 7.04e-07 | 1 / 0 | 5.76 | 0.331 | BENIGN | 0.31 | |
| 408 | p.Phe408Cys | c.1223T>G | 1.37e-06 | 2 / 0 | 5.76 | - | nan | - | |
| 408 | p.Phe408Leu | c.1222T>C | 2.05e-06 | 3 / 0 | 5.76 | - | nan | - | rs1297352198 |
| 408 | p.Ser408Thr | c.1222T>A | 7.16e-07 | 1 / 0 | 5.76 | - | nan | - | |
| 404 | p.Lys404Glu | c.1210A>G | 6.95e-07 | 1 / 0 | 5.76 | - | nan | - | |
| 300 | p.Met300Leu | c.898A>T | 6.85e-07 | 1 / 0 | 5.57 | 0.637 | PATHOGENIC | 0.85 | rs1878952382 |
| 300 | p.Met300Val | c.898A>G | 6.85e-07 | 1 / 0 | 5.57 | - | nan | - | |
| 199 | p.Arg199Ser | c.597A>T | 6.85e-07 | 1 / 0 | 5.44 | 1.000 | PATHOGENIC | 0.92 | |
| 247 | p.Tyr247Cys | c.740A>G | 9.58e-06 | 14 / 0 | 5.06 | 0.430 | AMBIGUOUS | 0.73 | rs200272603 |
| 39 | p.Glu39Gly | c.116A>G | 6.85e-07 | 1 / 0 | 5.06 | 0.135 | BENIGN | 0.67 | rs1274241424 |
| 109 | p.Cys109Ser | c.325T>A | 6.84e-07 | 1 / 0 | 5.03 | 0.221 | BENIGN | 0.73 | |
| 8 | p.Cys8Gly | c.22T>G | 6.57e-06 | 1 / 0 | 5.03 | 0.046 | BENIGN | 0.74 | rs765870134 |
| 8 | p.Met8Ile | c.24G>A | 6.86e-07 | 1 / 0 | 5.03 | - | nan | - | rs765515093 |
| 303 | p.Lys303Arg | c.908A>G | 3.43e-06 | 5 / 0 | 4.88 | 0.093 | BENIGN | 0.56 | rs1336420198 |
| 241 | p.Asp241Ala | c.722A>C | 5.48e-06 | 8 / 0 | 4.59 | 0.433 | AMBIGUOUS | 0.64 | rs201625400 |
| 241 | p.Asp241Asn | c.721G>A | 6.84e-07 | 1 / 0 | 4.59 | - | nan | - | rs762204581 |
| 4 | p.Pro4Ala | c.10C>G | 1.38e-06 | 2 / 0 | 4.59 | 0.054 | BENIGN | 0.71 | rs777992864 |
| 4 | p.Ser4Arg | c.12T>G | 6.88e-07 | 1 / 0 | 4.59 | - | nan | - | |
| 4 | p.Ser4Asn | c.11G>A | 3.44e-06 | 5 / 0 | 4.59 | - | nan | - | |
| 4 | p.Ser4Thr | c.11G>C | 8.87e-05 | 129 / 0 | 4.59 | - | nan | - | rs201115708 |
| 255 | p.Cys255Phe | c.764G>T | 6.85e-07 | 1 / 0 | 4.39 | 0.988 | PATHOGENIC | 0.87 | |
| 167 | p.Trp167Ser | c.500G>C | 1.37e-06 | 2 / 0 | 4.39 | 0.956 | PATHOGENIC | 0.69 | |
| 166 | p.Asp166Val | c.497A>T | 6.85e-07 | 1 / 0 | 4.35 | 0.360 | AMBIGUOUS | 0.60 | rs998395399 |
| 253 | p.Arg253Gln | c.758G>A | 2.74e-05 | 40 / 0 | 4.35 | 0.085 | BENIGN | 0.50 | rs140514830 |
| 330 | p.Leu330Pro | c.989T>C | 6.85e-07 | 1 / 0 | 4.29 | 0.982 | PATHOGENIC | 0.70 | |
| 330 | p.Leu330Phe | c.988C>T | 2.05e-06 | 3 / 0 | 4.29 | - | nan | - | |
| 270 | p.Lys270Gln | c.808A>C | 2.74e-06 | 4 / 0 | 4.27 | 0.183 | BENIGN | 0.52 | rs771549175 |
| 47 | p.Thr47Lys | c.140C>A | 7.05e-07 | 1 / 0 | 4.27 | 0.093 | BENIGN | 0.55 | rs1316261633 |
| 47 | p.Thr47Met | c.140C>T | 4.23e-06 | 6 / 0 | 4.27 | - | nan | - | |
| 47 | p.Gly47Val | c.140G>T | 3.42e-06 | 5 / 0 | 4.27 | - | nan | - | rs1183332009 |
| 47 | p.Gly47Asp | c.140G>A | 2.05e-06 | 3 / 0 | 4.27 | - | nan | - | |
| 147 | p.Asp147Tyr | c.439G>T | 6.84e-07 | 1 / 0 | 4.03 | 0.995 | PATHOGENIC | 0.96 | |
| 188 | p.Thr188Ile | c.563C>T | 1.37e-06 | 2 / 0 | 4.03 | 0.995 | PATHOGENIC | 0.90 | |
| 188 | p.Thr188Ser | c.563C>G | 6.85e-07 | 1 / 0 | 4.03 | - | nan | - | |
| 206 | p.Trp206Arg | c.616T>A | 6.58e-06 | 1 / 0 | 3.78 | 0.987 | PATHOGENIC | 0.92 | rs1410186437 |
| 409 | p.Met409Ile | c.1227G>A | 7.03e-07 | 1 / 0 | 3.58 | 0.305 | BENIGN | 0.43 | rs941247743 |
| 409 | p.Met409Ile | c.1227G>T | 7.03e-07 | 1 / 0 | 3.58 | - | nan | - | |
| 409 | p.Glu409Gly | c.1226A>G | 1.37e-06 | 2 / 0 | 3.58 | - | nan | - | |
| 409 | p.Glu409Lys | c.1225G>A | 6.85e-07 | 1 / 0 | 3.58 | - | nan | - | rs200670733 |
| 409 | p.Leu409Ser | c.1226T>C | 7.20e-07 | 1 / 0 | 3.58 | - | nan | - | rs770101988 |
| 112 | p.Phe112Leu | c.336C>A | 6.58e-06 | 1 / 0 | 3.57 | 0.966 | PATHOGENIC | 0.99 | rs1879914204 |
| 12 | p.Thr12Ile | c.35C>T | 6.85e-07 | 1 / 0 | 3.57 | 0.091 | BENIGN | 0.81 | rs201841569 |
| 12 | p.Thr12Asn | c.35C>A | 3.43e-06 | 5 / 0 | 3.57 | - | nan | - | rs201841569 |
| 198 | p.Asp198Ala | c.593A>C | 1.37e-06 | 2 / 0 | 3.53 | 0.997 | PATHOGENIC | 0.93 | |
| 29 | p.Val29Ile | c.85G>A | 1.37e-06 | 2 / 0 | 3.52 | 0.128 | BENIGN | 0.62 | rs773347747 |
| 27 | p.Glu27Gly | c.80A>G | 7.06e-07 | 1 / 0 | 3.52 | 0.065 | BENIGN | 0.67 | |
| 27 | p.Arg27Leu | c.80G>T | 3.42e-06 | 5 / 0 | 3.52 | - | nan | - | rs760706605 |
| 27 | p.Arg27Pro | c.80G>C | 6.85e-07 | 1 / 0 | 3.52 | - | nan | - | rs760706605 |
| 27 | p.Arg27Cys | c.79C>T | 2.74e-06 | 4 / 0 | 3.52 | - | nan | - | |
| 27 | p.Arg27Ser | c.79C>A | 6.85e-07 | 1 / 0 | 3.52 | - | nan | - | |
| 136 | p.Pro136Ser | c.406C>T | 1.37e-06 | 2 / 0 | 3.49 | 0.992 | PATHOGENIC | 0.98 | |
| 136 | p.Pro136Ala | c.406C>G | 6.84e-07 | 1 / 0 | 3.49 | - | nan | - | |
| 362 | p.Ser362Arg | c.1084A>C | 1.32e-05 | 2 / 0 | 3.45 | 0.809 | PATHOGENIC | 0.72 | rs369090616 |
| 254 | p.Ile254Thr | c.761T>C | 2.74e-06 | 4 / 0 | 3.38 | 0.294 | BENIGN | 0.56 | rs371057149 |
| 254 | p.Ile254Asn | c.761T>A | 2.74e-06 | 4 / 0 | 3.38 | - | nan | - | rs371057149 |
| 254 | p.Ile254Leu | c.760A>C | 1.37e-06 | 2 / 0 | 3.38 | - | nan | - | rs750477425 |
| 352 | p.Gln352Arg | c.1055A>G | 3.42e-06 | 5 / 0 | 3.20 | 0.089 | BENIGN | 0.49 | rs1397373759 |
| 260 | p.Val260Gly | c.779T>G | 3.56e-05 | 52 / 0 | 3.12 | 0.134 | BENIGN | 0.20 | rs1220991715 |
| 44 | p.Glu44Asp | c.132G>T | 1.41e-06 | 2 / 0 | 3.12 | 0.077 | BENIGN | 0.63 | rs1401360436 |
| 260 | p.Val260Phe | c.778G>T | 1.56e-03 | 2269 / 2 | 3.12 | - | nan | - | rs77132068 |
| 260 | p.Val260Ile | c.778G>A | 2.12e-04 | 307 / 1 | 3.12 | - | nan | - | rs77132068 |
| 44 | p.Glu44Val | c.131A>T | 4.25e-06 | 6 / 0 | 3.12 | - | nan | - | rs755457512 |
| 44 | p.Pro44Leu | c.131C>T | 3.42e-05 | 50 / 0 | 3.12 | - | nan | - | rs201601278 |
| 44 | p.Pro44Ser | c.130C>T | 6.57e-06 | 1 / 0 | 3.12 | - | nan | - | rs1447007979 |
| 124 | p.Arg124Lys | c.371G>A | 4.10e-06 | 6 / 0 | 3.05 | 0.204 | BENIGN | 0.91 | rs541269180 |
| 97 | p.Lys97Glu | c.289A>G | 1.37e-06 | 2 / 0 | 3.05 | 0.149 | BENIGN | 0.59 | rs1280780830 |
| 97 | p.Lys97Gln | c.289A>C | 6.84e-07 | 1 / 0 | 3.05 | - | nan | - | |
| 40 | p.Ala40Glu | c.119C>A | 1.37e-06 | 2 / 0 | 3.04 | 0.121 | BENIGN | 0.74 | rs749692138 |
| 40 | p.Ala40Val | c.119C>T | 6.85e-07 | 1 / 0 | 3.04 | - | nan | - | |
| 40 | p.Ala40Thr | c.118G>A | 6.85e-07 | 1 / 0 | 3.04 | - | nan | - | |
| 40 | p.Ala40Ser | c.118G>T | 4.79e-06 | 7 / 0 | 3.04 | - | nan | - | |
| 40 | p.Ala40Pro | c.118G>C | 6.85e-07 | 1 / 0 | 3.04 | - | nan | - |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.26, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 41 | GLN | 94 | ILE | 0.000 | 19.115 | -19.115 | 19.115 |
| 343 | ARG | 368 | ASP | 0.109 | 9.910 | -9.801 | 9.801 |
| 399 | SER | 406 | GLN | 0.000 | 9.393 | -9.393 | 9.393 |
| 38 | PRO | 165 | GLU | 0.000 | 8.706 | -8.706 | 8.706 |
| 3 | PRO | 102 | TYR | 0.000 | 8.620 | -8.620 | 8.620 |
| 293 | TYR | 326 | PHE | 0.760 | 8.484 | -7.724 | 7.724 |
| 201 | ARG | 208 | ARG | 0.000 | 6.633 | -6.633 | 6.633 |
| 430 | TYR | 431 | ASP | 6.314 | 0.000 | 6.314 | 6.314 |
| 43 | ALA | 256 | LEU | 0.000 | 6.104 | -6.104 | 6.104 |
| 293 | TYR | 325 | VAL | 6.003 | 0.000 | 6.003 | 6.003 |
| 261 | GLN | 267 | GLN | 5.067 | 10.908 | -5.841 | 5.841 |
| 127 | TYR | 133 | ARG | 0.111 | 5.942 | -5.831 | 5.831 |
| 404 | TRP | 408 | PHE | 5.757 | 0.000 | 5.757 | 5.757 |
| 300 | MET | 318 | ARG | 5.691 | 0.120 | 5.572 | 5.572 |
| 199 | ARG | 293 | TYR | 5.441 | 0.000 | 5.441 | 5.441 |
| 39 | LEU | 247 | TYR | 0.000 | 5.058 | -5.058 | 5.058 |
| 8 | CYS | 109 | CYS | 0.000 | 5.026 | -5.026 | 5.026 |
| 299 | GLU | 303 | LYS | 0.000 | 4.881 | -4.881 | 4.881 |
| 196 | SER | 293 | TYR | 4.631 | 0.000 | 4.631 | 4.631 |
| 175 | LYS | 241 | ASP | 0.037 | 4.629 | -4.592 | 4.592 |
| 4 | PRO | 102 | TYR | 0.000 | 4.590 | -4.590 | 4.590 |
| 342 | SER | 367 | LEU | 2.246 | 6.654 | -4.408 | 4.408 |
| 167 | TRP | 255 | CYS | 2.367 | 6.761 | -4.394 | 4.394 |
| 166 | ASP | 253 | ARG | 7.370 | 3.025 | 4.345 | 4.345 |
| 326 | PHE | 330 | LEU | 0.000 | 4.294 | -4.294 | 4.294 |
| 47 | THR | 270 | LYS | 0.000 | 4.269 | -4.269 | 4.269 |
| 147 | ASP | 188 | THR | 4.570 | 0.542 | 4.028 | 4.028 |
| 206 | TRP | 303 | LYS | 0.000 | 3.782 | -3.782 | 3.782 |
| 398 | LYS | 409 | GLU | 0.000 | 3.582 | -3.582 | 3.582 |
| 12 | LEU | 112 | PHE | 0.000 | 3.569 | -3.569 | 3.569 |
| 198 | ASP | 199 | ARG | 0.000 | 3.531 | -3.531 | 3.531 |
| 27 | GLU | 29 | ARG | 0.000 | 3.520 | -3.520 | 3.520 |
| 136 | PRO | 199 | ARG | 0.000 | 3.485 | -3.485 | 3.485 |
| 94 | ILE | 362 | SER | 1.601 | 5.048 | -3.447 | 3.447 |
| 240 | PHE | 257 | LEU | 5.054 | 8.458 | -3.404 | 3.404 |
| 43 | ALA | 254 | ILE | 0.000 | 3.379 | -3.379 | 3.379 |
| 206 | TRP | 311 | LEU | 0.000 | 3.362 | -3.362 | 3.362 |
| 199 | ARG | 321 | VAL | 0.000 | 3.337 | -3.337 | 3.337 |
| 39 | LEU | 165 | GLU | 0.000 | 3.249 | -3.249 | 3.249 |
| 352 | GLN | 357 | ARG | 1.685 | 4.889 | -3.204 | 3.204 |
| 44 | GLU | 260 | VAL | 3.121 | 0.000 | 3.121 | 3.121 |
| 124 | ARG | 128 | LYS | 0.000 | 3.055 | -3.055 | 3.055 |
| 25 | TRP | 97 | LYS | 3.048 | 0.000 | 3.048 | 3.048 |
| 40 | LEU | 41 | GLN | 3.044 | 0.000 | 3.044 | 3.044 |
| 94 | ILE | 361 | LEU | 0.779 | 3.818 | -3.039 | 3.039 |
| 332 | PHE | 336 | TRP | 4.334 | 7.365 | -3.031 | 3.031 |
| 149 | LEU | 184 | SER | 4.266 | 1.247 | 3.019 | 3.019 |
| 90 | CYS | 357 | ARG | 6.543 | 3.587 | 2.956 | 2.956 |
| 112 | PHE | 116 | ILE | 3.706 | 0.793 | 2.914 | 2.914 |
| 350 | TYR | 357 | ARG | 0.348 | 3.219 | -2.871 | 2.871 |
| 269 | TYR | 273 | LYS | 0.133 | 3.001 | -2.868 | 2.868 |
| 201 | ARG | 209 | ILE | 2.867 | 0.000 | 2.867 | 2.867 |
| 58 | SER | 59 | ASN | 2.806 | 0.000 | 2.806 | 2.806 |
| 94 | ILE | 358 | CYS | 2.882 | 5.686 | -2.804 | 2.804 |
| 240 | PHE | 256 | LEU | 6.018 | 8.815 | -2.797 | 2.797 |
| 91 | GLN | 355 | PRO | 0.838 | 3.593 | -2.755 | 2.755 |
| 247 | TYR | 248 | LYS | 5.208 | 7.960 | -2.752 | 2.752 |
| 297 | THR | 326 | PHE | 2.723 | 0.000 | 2.723 | 2.723 |
| 12 | LEU | 156 | PRO | 0.000 | 2.668 | -2.668 | 2.668 |
| 104 | ASN | 373 | ASN | 4.523 | 7.172 | -2.649 | 2.649 |
| 202 | ALA | 209 | ILE | 2.639 | 0.000 | 2.639 | 2.639 |
| 71 | VAL | 72 | PRO | 1.239 | 3.861 | -2.622 | 2.622 |
| 296 | MET | 322 | ALA | 0.000 | 2.612 | -2.612 | 2.612 |
| 16 | VAL | 156 | PRO | 0.000 | 2.605 | -2.605 | 2.605 |
| 44 | GLU | 346 | LYS | 0.000 | 2.564 | -2.564 | 2.564 |
| 324 | THR | 389 | VAL | 2.511 | 5.038 | -2.527 | 2.527 |
| 436 | SER | 437 | ASN | 2.516 | 0.000 | 2.516 | 2.516 |
| 276 | TRP | 280 | PHE | 5.282 | 7.762 | -2.480 | 2.480 |
| 167 | TRP | 169 | PHE | 2.592 | 5.061 | -2.469 | 2.469 |
| 185 | VAL | 336 | TRP | 2.906 | 5.350 | -2.444 | 2.444 |
| 202 | ALA | 318 | ARG | 0.000 | 2.436 | -2.436 | 2.436 |
| 294 | THR | 326 | PHE | 2.340 | 0.000 | 2.340 | 2.340 |
| 44 | GLU | 259 | PRO | 2.336 | 0.000 | 2.336 | 2.336 |
| 339 | LEU | 343 | ARG | 2.734 | 0.406 | 2.328 | 2.328 |
| 198 | ASP | 210 | LYS | 0.000 | 2.315 | -2.315 | 2.315 |
| 339 | LEU | 371 | GLY | 2.192 | 4.496 | -2.304 | 2.304 |
| 293 | TYR | 297 | THR | 0.000 | 2.286 | -2.286 | 2.286 |
| 5 | PRO | 102 | TYR | 0.000 | 2.282 | -2.282 | 2.282 |
| 243 | ILE | 258 | HIS | 1.255 | 3.538 | -2.282 | 2.282 |
| 252 | LEU | 254 | ILE | 0.189 | 2.387 | -2.198 | 2.198 |
| 232 | LEU | 281 | TYR | 0.000 | 2.197 | -2.197 | 2.197 |
| 8 | CYS | 388 | LEU | 2.189 | 0.000 | 2.189 | 2.189 |
| 5 | PRO | 10 | ARG | 2.343 | 0.167 | 2.175 | 2.175 |
| 157 | ILE | 169 | PHE | 0.000 | 2.171 | -2.171 | 2.171 |
| 289 | THR | 329 | VAL | 1.317 | 3.477 | -2.161 | 2.161 |
| 282 | PHE | 286 | LEU | 0.843 | 2.991 | -2.147 | 2.147 |
| 342 | SER | 368 | ASP | 4.369 | 6.514 | -2.144 | 2.144 |
| 131 | CYS | 392 | ARG | 4.898 | 7.022 | -2.123 | 2.123 |
| 235 | PRO | 269 | TYR | 4.504 | 6.617 | -2.113 | 2.113 |
| 124 | ARG | 400 | CYS | 0.011 | 2.094 | -2.083 | 2.083 |
| 54 | TRP | 55 | PRO | 2.431 | 0.352 | 2.080 | 2.080 |
| 196 | SER | 325 | VAL | 0.000 | 2.021 | -2.021 | 2.021 |
| 203 | VAL | 318 | ARG | 0.000 | 2.000 | -2.000 | 2.000 |
| 203 | VAL | 300 | MET | 2.945 | 0.957 | 1.987 | 1.987 |
| 238 | ILE | 266 | MET | 0.000 | 1.982 | -1.982 | 1.982 |
| 387 | TYR | 394 | LYS | 6.462 | 8.410 | -1.948 | 1.948 |
| 168 | PRO | 169 | PHE | 1.796 | 3.738 | -1.942 | 1.942 |
| 48 | PRO | 352 | GLN | 0.000 | 1.930 | -1.930 | 1.930 |
| 42 | THR | 247 | TYR | 0.000 | 1.927 | -1.927 | 1.927 |
| 136 | PRO | 195 | LEU | 0.000 | 1.887 | -1.887 | 1.887 |
| 319 | ARG | 323 | LYS | 0.000 | 1.881 | -1.881 | 1.881 |
| 311 | LEU | 314 | HIS | 1.859 | 0.000 | 1.859 | 1.859 |
| 197 | ILE | 201 | ARG | 2.521 | 0.714 | 1.808 | 1.808 |
| 434 | ARG | 435 | SER | 1.805 | 0.000 | 1.805 | 1.805 |
| 177 | VAL | 181 | GLN | 1.796 | 0.000 | 1.796 | 1.796 |
| 277 | LEU | 343 | ARG | 1.778 | 0.000 | 1.778 | 1.778 |
| 146 | GLY | 188 | THR | 1.730 | 0.000 | 1.730 | 1.730 |
| 126 | ILE | 133 | ARG | 0.688 | 2.416 | -1.728 | 1.728 |
| 282 | PHE | 337 | LEU | 1.552 | 3.279 | -1.727 | 1.727 |
| 328 | LEU | 382 | ASN | 0.000 | 1.726 | -1.726 | 1.726 |
| 307 | MET | 311 | LEU | 1.737 | 0.011 | 1.726 | 1.726 |
| 182 | LYS | 236 | GLU | 2.185 | 3.911 | -1.725 | 1.725 |
| 203 | VAL | 303 | LYS | 0.000 | 1.711 | -1.711 | 1.711 |
| 12 | LEU | 331 | VAL | 1.709 | 0.000 | 1.709 | 1.709 |
| 204 | ALA | 303 | LYS | 0.000 | 1.703 | -1.703 | 1.703 |
| 196 | SER | 292 | PHE | 2.677 | 0.989 | 1.688 | 1.688 |
| 433 | PHE | 434 | ARG | 1.629 | 0.000 | 1.629 | 1.629 |
| 205 | SER | 209 | ILE | 1.628 | 0.000 | 1.628 | 1.628 |
| 300 | MET | 319 | ARG | 0.000 | 1.624 | -1.624 | 1.624 |
| 150 | HIS | 181 | GLN | 0.109 | 1.730 | -1.621 | 1.621 |
| 91 | GLN | 356 | ASN | 0.244 | 1.865 | -1.620 | 1.620 |
| 111 | VAL | 380 | CYS | 1.914 | 3.534 | -1.619 | 1.619 |
| 285 | PRO | 332 | PHE | 1.649 | 0.050 | 1.599 | 1.599 |
| 239 | GLY | 261 | GLN | 2.840 | 4.426 | -1.586 | 1.586 |
| 352 | GLN | 353 | ASN | 0.116 | 1.682 | -1.566 | 1.566 |
| 175 | LYS | 237 | ALA | 4.517 | 6.073 | -1.556 | 1.556 |
| 377 | LEU | 381 | ILE | 0.197 | 1.748 | -1.552 | 1.552 |
| 278 | PHE | 282 | PHE | 4.051 | 2.500 | 1.551 | 1.551 |
| 266 | MET | 269 | TYR | 2.436 | 0.899 | 1.537 | 1.537 |
| 331 | VAL | 381 | ILE | 1.799 | 3.332 | -1.533 | 1.533 |
| 137 | ASN | 393 | PHE | 1.144 | 2.661 | -1.517 | 1.517 |
| 153 | ILE | 180 | ILE | 0.872 | 2.385 | -1.513 | 1.513 |
| 168 | PRO | 253 | ARG | 3.316 | 1.805 | 1.511 | 1.511 |
| 150 | HIS | 154 | ASP | 2.314 | 3.823 | -1.509 | 1.509 |
| 132 | MET | 137 | ASN | 8.136 | 6.654 | 1.482 | 1.482 |
| 350 | TYR | 361 | LEU | 1.480 | 0.000 | 1.480 | 1.480 |
| 435 | SER | 436 | SER | 1.480 | 0.000 | 1.480 | 1.480 |
| 182 | LYS | 277 | LEU | 0.515 | 1.985 | -1.470 | 1.470 |
| 175 | LYS | 240 | PHE | 3.221 | 4.653 | -1.432 | 1.432 |
| 330 | LEU | 334 | LEU | 1.427 | 0.000 | 1.427 | 1.427 |
| 293 | TYR | 329 | VAL | 1.424 | 0.000 | 1.424 | 1.424 |
| 112 | PHE | 151 | ILE | 2.754 | 4.177 | -1.423 | 1.423 |
| 143 | LEU | 192 | LEU | 1.453 | 0.034 | 1.419 | 1.419 |
| 181 | GLN | 182 | LYS | 1.323 | 2.742 | -1.419 | 1.419 |
| 162 | LEU | 369 | TYR | 7.612 | 9.029 | -1.417 | 1.417 |
| 143 | LEU | 191 | SER | 2.255 | 0.863 | 1.392 | 1.392 |
| 297 | THR | 322 | ALA | 1.389 | 0.000 | 1.389 | 1.389 |
| 95 | GLU | 362 | SER | 0.689 | 2.053 | -1.363 | 1.363 |
| 41 | GLN | 93 | PRO | 0.000 | 1.357 | -1.357 | 1.357 |
| 111 | VAL | 155 | ILE | 0.000 | 1.355 | -1.355 | 1.355 |
| 100 | PHE | 104 | ASN | 1.804 | 3.141 | -1.337 | 1.337 |
| 282 | PHE | 340 | HIS | 2.720 | 4.055 | -1.335 | 1.335 |
| 65 | SER | 66 | LEU | 0.101 | 1.435 | -1.334 | 1.334 |
| 274 | ASP | 343 | ARG | 4.144 | 2.828 | 1.316 | 1.316 |
| 112 | PHE | 155 | ILE | 1.422 | 2.734 | -1.312 | 1.312 |
| 265 | PHE | 266 | MET | 0.000 | 1.312 | -1.312 | 1.312 |
| 439 | TYR | 440 | SER | 1.298 | 0.000 | 1.298 | 1.298 |
| 307 | MET | 308 | GLN | 0.000 | 1.293 | -1.293 | 1.293 |
| 136 | PRO | 198 | ASP | 3.500 | 2.208 | 1.293 | 1.293 |
| 160 | TYR | 164 | ALA | 2.359 | 3.652 | -1.292 | 1.292 |
| 121 | THR | 401 | LEU | 0.211 | 1.503 | -1.292 | 1.292 |
| 150 | HIS | 376 | SER | 1.468 | 2.747 | -1.279 | 1.279 |
| 440 | SER | 441 | SER | 1.272 | 0.000 | 1.272 | 1.272 |
| 160 | TYR | 168 | PRO | 3.723 | 4.989 | -1.266 | 1.266 |
| 182 | LYS | 281 | TYR | 3.546 | 2.298 | 1.247 | 1.247 |
| 150 | HIS | 185 | VAL | 1.241 | 0.000 | 1.241 | 1.241 |
| 13 | VAL | 160 | TYR | 0.000 | 1.220 | -1.220 | 1.220 |
| 276 | TRP | 281 | TYR | 0.165 | 1.384 | -1.219 | 1.219 |
| 189 | VAL | 332 | PHE | 0.548 | 1.748 | -1.201 | 1.201 |
| 167 | TRP | 174 | CYS | 4.612 | 5.812 | -1.200 | 1.200 |
| 146 | GLY | 184 | SER | 0.685 | 1.883 | -1.197 | 1.197 |
| 275 | TRP | 344 | ILE | 1.064 | 2.258 | -1.193 | 1.193 |
| 296 | MET | 325 | VAL | 1.191 | 0.000 | 1.191 | 1.191 |
| 119 | ASN | 383 | PRO | 3.772 | 4.958 | -1.185 | 1.185 |
| 47 | THR | 259 | PRO | 0.000 | 1.182 | -1.182 | 1.182 |
| 134 | ASN | 137 | ASN | 5.858 | 7.039 | -1.181 | 1.181 |
| 40 | LEU | 165 | GLU | 0.000 | 1.178 | -1.178 | 1.178 |
| 243 | ILE | 245 | MET | 0.000 | 1.175 | -1.175 | 1.175 |
| 93 | PRO | 95 | GLU | 3.100 | 4.275 | -1.175 | 1.175 |
| 402 | CYS | 405 | CYS | 0.000 | 1.170 | -1.170 | 1.170 |
| 153 | ILE | 181 | GLN | 1.151 | 0.000 | 1.151 | 1.151 |
| 161 | LYS | 167 | TRP | 0.000 | 1.151 | -1.151 | 1.151 |
| 243 | ILE | 254 | ILE | 6.490 | 5.349 | 1.141 | 1.141 |
| 39 | LEU | 41 | GLN | 0.000 | 1.134 | -1.134 | 1.134 |
| 160 | TYR | 166 | ASP | 0.793 | 1.916 | -1.123 | 1.123 |
| 281 | TYR | 332 | PHE | 0.678 | 1.795 | -1.116 | 1.116 |
| 336 | TRP | 375 | ALA | 2.583 | 3.692 | -1.109 | 1.109 |
| 335 | CYS | 378 | ASN | 2.338 | 3.446 | -1.108 | 1.108 |
| 149 | LEU | 226 | TRP | 0.000 | 1.102 | -1.102 | 1.102 |
| 45 | ILE | 361 | LEU | 0.000 | 1.100 | -1.100 | 1.100 |
| 38 | PRO | 101 | LYS | 0.000 | 1.099 | -1.099 | 1.099 |
| 208 | ARG | 210 | LYS | 0.000 | 1.096 | -1.096 | 1.096 |
| 199 | ARG | 325 | VAL | 0.249 | 1.315 | -1.066 | 1.066 |
| 196 | SER | 288 | ILE | 1.063 | 0.000 | 1.063 | 1.063 |
| 320 | GLU | 389 | VAL | 0.000 | 1.063 | -1.063 | 1.063 |
| 143 | LEU | 382 | ASN | 2.998 | 1.936 | 1.063 | 1.063 |
| 134 | ASN | 213 | GLY | 2.079 | 1.019 | 1.060 | 1.060 |
| 132 | MET | 393 | PHE | 2.947 | 4.004 | -1.056 | 1.056 |
| 39 | LEU | 252 | LEU | 0.000 | 1.056 | -1.056 | 1.056 |
| 336 | TRP | 378 | ASN | 3.042 | 4.094 | -1.052 | 1.052 |
| 93 | PRO | 358 | CYS | 0.000 | 1.051 | -1.051 | 1.051 |
| 119 | ASN | 147 | ASP | 2.095 | 3.145 | -1.050 | 1.050 |
| 120 | SER | 148 | LEU | 0.680 | 1.729 | -1.048 | 1.048 |
| 88 | PRO | 353 | ASN | 0.424 | 1.463 | -1.039 | 1.039 |
| 134 | ASN | 136 | PRO | 2.003 | 3.041 | -1.037 | 1.037 |
| 259 | PRO | 270 | LYS | 6.217 | 5.179 | 1.037 | 1.037 |
| 236 | GLU | 240 | PHE | 3.724 | 2.691 | 1.033 | 1.033 |
| 142 | SER | 222 | ILE | 0.528 | 1.550 | -1.022 | 1.022 |
| 200 | TYR | 204 | ALA | 2.132 | 1.115 | 1.017 | 1.017 |
| 96 | ILE | 365 | LEU | 0.019 | 1.033 | -1.014 | 1.014 |
| 49 | PRO | 50 | THR | 1.014 | 0.000 | 1.014 | 1.014 |
| 260 | VAL | 267 | GLN | 0.000 | 1.006 | -1.006 | 1.006 |
| 46 | MET | 259 | PRO | 0.000 | 1.006 | -1.006 | 1.006 |
| 125 | ILE | 400 | CYS | 1.232 | 0.242 | 0.990 | 0.990 |
| 291 | PHE | 292 | PHE | 0.922 | 1.908 | -0.987 | 0.987 |
| 116 | ILE | 151 | ILE | 0.000 | 0.976 | -0.976 | 0.976 |
| 98 | GLU | 101 | LYS | 5.548 | 4.574 | 0.973 | 0.973 |
| 149 | LEU | 180 | ILE | 1.296 | 0.330 | 0.966 | 0.966 |
| 204 | ALA | 299 | GLU | 0.000 | 0.966 | -0.966 | 0.966 |
| 101 | LYS | 162 | LEU | 3.657 | 4.622 | -0.965 | 0.965 |
| 338 | PRO | 367 | LEU | 1.595 | 0.630 | 0.965 | 0.965 |
| 19 | CYS | 374 | MET | 0.964 | 0.000 | 0.964 | 0.964 |
| 45 | ILE | 350 | TYR | 0.000 | 0.963 | -0.963 | 0.963 |
| 40 | LEU | 369 | TYR | 0.000 | 0.955 | -0.955 | 0.955 |
| 284 | LEU | 288 | ILE | 0.625 | 1.574 | -0.949 | 0.949 |
| 145 | LEU | 226 | TRP | 1.588 | 0.659 | 0.928 | 0.928 |
| 167 | TRP | 253 | ARG | 6.282 | 5.358 | 0.925 | 0.925 |
| 350 | TYR | 352 | GLN | 0.000 | 0.912 | -0.912 | 0.912 |
| 200 | TYR | 295 | LEU | 3.221 | 4.111 | -0.890 | 0.890 |
| 12 | LEU | 327 | CYS | 0.889 | 0.000 | 0.889 | 0.889 |
| 232 | LEU | 276 | TRP | 1.758 | 0.871 | 0.887 | 0.887 |
| 354 | ASP | 355 | PRO | 2.710 | 1.840 | 0.870 | 0.870 |
| 33 | PRO | 34 | ASP | 0.000 | 0.867 | -0.867 | 0.867 |
| 125 | ILE | 132 | MET | 0.171 | 1.036 | -0.865 | 0.865 |
| 280 | PHE | 281 | TYR | 3.366 | 2.511 | 0.855 | 0.855 |
| 351 | ASN | 357 | ARG | 0.847 | 1.697 | -0.850 | 0.850 |
| 293 | TYR | 296 | MET | 0.845 | 0.000 | 0.845 | 0.845 |
| 167 | TRP | 173 | MET | 2.015 | 2.854 | -0.839 | 0.839 |
| 88 | PRO | 357 | ARG | 4.279 | 5.114 | -0.835 | 0.835 |
| 290 | ALA | 329 | VAL | 0.830 | 0.000 | 0.830 | 0.830 |
| 190 | LEU | 225 | ILE | 2.356 | 3.184 | -0.829 | 0.829 |
| 147 | ASP | 382 | ASN | 2.799 | 3.627 | -0.828 | 0.828 |
| 194 | ALA | 221 | GLU | 1.849 | 2.668 | -0.818 | 0.818 |
| 100 | PHE | 369 | TYR | 0.986 | 1.803 | -0.817 | 0.817 |
| 192 | LEU | 332 | PHE | 0.844 | 1.654 | -0.809 | 0.809 |
| 346 | LYS | 364 | LEU | 1.724 | 2.531 | -0.807 | 0.807 |
| 183 | ALA | 229 | SER | 3.082 | 3.888 | -0.806 | 0.806 |
| 267 | GLN | 270 | LYS | 0.000 | 0.804 | -0.804 | 0.804 |
| 139 | LEU | 218 | THR | 1.094 | 0.291 | 0.802 | 0.802 |
| 185 | VAL | 281 | TYR | 2.456 | 3.242 | -0.787 | 0.787 |
| 119 | ASN | 148 | LEU | 1.012 | 1.792 | -0.780 | 0.780 |
| 105 | THR | 163 | LEU | 1.063 | 1.840 | -0.777 | 0.777 |
| 195 | LEU | 199 | ARG | 0.775 | 0.000 | 0.775 | 0.775 |
| 96 | ILE | 369 | TYR | 0.642 | 1.415 | -0.772 | 0.772 |
| 300 | MET | 321 | VAL | 0.769 | 0.000 | 0.769 | 0.769 |
| 139 | LEU | 221 | GLU | 0.000 | 0.767 | -0.767 | 0.767 |
| 50 | THR | 51 | LYS | 0.763 | 0.000 | 0.763 | 0.763 |
| 115 | GLY | 380 | CYS | 1.933 | 2.695 | -0.762 | 0.762 |
| 179 | PHE | 237 | ALA | 2.174 | 1.413 | 0.761 | 0.761 |
| 339 | LEU | 368 | ASP | 1.213 | 0.455 | 0.758 | 0.758 |
| 143 | LEU | 195 | LEU | 0.751 | 0.000 | 0.751 | 0.751 |
| 257 | LEU | 266 | MET | 0.744 | 0.000 | 0.744 | 0.744 |
| 178 | PRO | 236 | GLU | 1.632 | 2.374 | -0.742 | 0.742 |
| 354 | ASP | 356 | ASN | 2.579 | 1.856 | 0.723 | 0.723 |
| 31 | PHE | 32 | PRO | 2.309 | 1.590 | 0.719 | 0.719 |
| 158 | ASN | 369 | TYR | 1.725 | 1.006 | 0.719 | 0.719 |
| 122 | LEU | 383 | PRO | 1.114 | 0.398 | 0.716 | 0.716 |
| 155 | ILE | 376 | SER | 2.678 | 1.975 | 0.704 | 0.704 |
| 323 | LYS | 389 | VAL | 0.000 | 0.703 | -0.703 | 0.703 |
| 153 | ILE | 177 | VAL | 0.672 | 1.373 | -0.701 | 0.701 |
| 187 | ILE | 225 | ILE | 0.626 | 1.323 | -0.697 | 0.697 |
| 87 | PRO | 352 | GLN | 1.195 | 1.891 | -0.696 | 0.696 |
| 6 | SER | 105 | THR | 0.000 | 0.695 | -0.695 | 0.695 |
| 135 | GLY | 214 | VAL | 0.766 | 0.077 | 0.690 | 0.690 |
| 279 | SER | 284 | LEU | 2.503 | 3.190 | -0.687 | 0.687 |
| 108 | SER | 155 | ILE | 1.800 | 2.486 | -0.686 | 0.686 |
| 263 | THR | 266 | MET | 1.133 | 1.819 | -0.685 | 0.685 |
| 282 | PHE | 332 | PHE | 0.276 | 0.961 | -0.685 | 0.685 |
| 40 | LEU | 365 | LEU | 0.000 | 0.682 | -0.682 | 0.682 |
| 205 | SER | 208 | ARG | 0.492 | 1.174 | -0.681 | 0.681 |
| 151 | ILE | 376 | SER | 0.772 | 0.091 | 0.681 | 0.681 |
| 170 | GLY | 242 | ILE | 2.409 | 3.087 | -0.678 | 0.678 |
| 154 | ASP | 376 | SER | 0.429 | 1.106 | -0.677 | 0.677 |
| 224 | LEU | 228 | VAL | 0.671 | 0.000 | 0.671 | 0.671 |
| 387 | TYR | 397 | PHE | 4.524 | 3.854 | 0.670 | 0.670 |
| 125 | ILE | 397 | PHE | 4.277 | 4.945 | -0.667 | 0.667 |
| 293 | TYR | 322 | ALA | 0.000 | 0.664 | -0.664 | 0.664 |
| 341 | LEU | 345 | LEU | 1.264 | 1.927 | -0.663 | 0.663 |
| 324 | THR | 386 | LEU | 0.000 | 0.657 | -0.657 | 0.657 |
| 165 | GLU | 252 | LEU | 0.000 | 0.657 | -0.657 | 0.657 |
| 155 | ILE | 373 | ASN | 0.656 | 0.000 | 0.656 | 0.656 |
| 220 | VAL | 224 | LEU | 0.000 | 0.654 | -0.654 | 0.654 |
| 331 | VAL | 378 | ASN | 1.033 | 1.685 | -0.653 | 0.653 |
| 46 | MET | 245 | MET | 0.653 | 0.000 | 0.653 | 0.653 |
| 12 | LEU | 159 | VAL | 0.000 | 0.650 | -0.650 | 0.650 |
| 133 | ARG | 213 | GLY | 0.857 | 1.505 | -0.648 | 0.648 |
| 13 | VAL | 17 | LEU | 1.163 | 0.516 | 0.647 | 0.647 |
| 151 | ILE | 155 | ILE | 0.109 | 0.754 | -0.645 | 0.645 |
| 116 | ILE | 148 | LEU | 1.083 | 1.726 | -0.644 | 0.644 |
| 61 | SER | 62 | LEU | 0.805 | 1.446 | -0.640 | 0.640 |
| 157 | ILE | 167 | TRP | 0.796 | 1.433 | -0.637 | 0.637 |
| 44 | GLU | 270 | LYS | 0.631 | 0.000 | 0.631 | 0.631 |
| 432 | ASN | 433 | PHE | 0.630 | 0.000 | 0.630 | 0.630 |
| 200 | TYR | 296 | MET | 2.834 | 2.205 | 0.629 | 0.629 |
| 297 | THR | 301 | LEU | 1.006 | 0.383 | 0.623 | 0.623 |
| 167 | TRP | 242 | ILE | 1.229 | 1.851 | -0.622 | 0.622 |
| 254 | ILE | 256 | LEU | 1.560 | 0.941 | 0.619 | 0.619 |
| 133 | ARG | 138 | ILE | 0.153 | 0.769 | -0.616 | 0.616 |
| 45 | ILE | 352 | GLN | 0.614 | 0.000 | 0.614 | 0.614 |
| 188 | THR | 378 | ASN | 0.000 | 0.611 | -0.611 | 0.611 |
| 197 | ILE | 292 | PHE | 3.991 | 4.599 | -0.609 | 0.609 |
| 116 | ILE | 152 | VAL | 0.147 | 0.753 | -0.606 | 0.606 |
| 269 | TYR | 276 | TRP | 0.864 | 0.259 | 0.604 | 0.604 |
| 115 | GLY | 151 | ILE | 1.128 | 1.731 | -0.604 | 0.604 |
| 143 | LEU | 147 | ASP | 1.821 | 1.218 | 0.603 | 0.603 |
| 268 | PHE | 272 | ALA | 0.941 | 1.541 | -0.600 | 0.600 |
| 441 | SER | 442 | SER | 0.600 | 0.000 | 0.600 | 0.600 |
| 192 | LEU | 328 | LEU | 0.000 | 0.597 | -0.597 | 0.597 |
| 142 | SER | 187 | ILE | 0.566 | 1.162 | -0.596 | 0.596 |
| 261 | GLN | 266 | MET | 7.168 | 6.576 | 0.592 | 0.592 |
| 296 | MET | 318 | ARG | 0.000 | 0.591 | -0.591 | 0.591 |
| 289 | THR | 293 | TYR | 0.591 | 0.000 | 0.591 | 0.591 |
| 336 | TRP | 340 | HIS | 1.407 | 0.817 | 0.590 | 0.590 |
| 286 | LEU | 333 | ALA | 0.550 | 1.139 | -0.589 | 0.589 |
| 135 | GLY | 213 | GLY | 1.085 | 0.501 | 0.584 | 0.584 |
| 133 | ARG | 214 | VAL | 0.686 | 1.268 | -0.583 | 0.583 |
| 199 | ARG | 296 | MET | 1.976 | 1.397 | 0.580 | 0.580 |
| 157 | ILE | 177 | VAL | 0.549 | 1.126 | -0.577 | 0.577 |
| 92 | GLY | 358 | CYS | 1.119 | 1.695 | -0.576 | 0.576 |
| 90 | CYS | 355 | PRO | 1.912 | 2.489 | -0.576 | 0.576 |
| 174 | CYS | 241 | ASP | 2.076 | 2.651 | -0.575 | 0.575 |
| 123 | LEU | 145 | LEU | 1.304 | 1.875 | -0.571 | 0.571 |
| 246 | ASP | 251 | TYR | 0.000 | 0.568 | -0.568 | 0.568 |
| 6 | SER | 320 | GLU | 0.567 | 0.000 | 0.567 | 0.567 |
| 124 | ARG | 404 | TRP | 0.566 | 0.000 | 0.566 | 0.566 |
| 17 | LEU | 21 | LEU | 0.000 | 0.559 | -0.559 | 0.559 |
| 100 | PHE | 366 | VAL | 4.689 | 4.132 | 0.557 | 0.557 |
| 277 | LEU | 282 | PHE | 0.511 | 1.067 | -0.556 | 0.556 |
| 215 | PRO | 218 | THR | 2.826 | 2.273 | 0.553 | 0.553 |
| 259 | PRO | 267 | GLN | 0.000 | 0.551 | -0.551 | 0.551 |
| 38 | PRO | 94 | ILE | 0.000 | 0.551 | -0.551 | 0.551 |
| 150 | HIS | 184 | SER | 2.425 | 2.975 | -0.550 | 0.550 |
| 205 | SER | 207 | SER | 0.000 | 0.550 | -0.550 | 0.550 |
| 139 | LEU | 194 | ALA | 0.590 | 1.137 | -0.547 | 0.547 |
| 191 | SER | 225 | ILE | 1.108 | 1.654 | -0.546 | 0.546 |
| 59 | ASN | 60 | ALA | 0.009 | 0.541 | -0.532 | 0.532 |
| 261 | GLN | 270 | LYS | 0.028 | 0.557 | -0.529 | 0.529 |
| 278 | PHE | 283 | CYS | 6.016 | 6.542 | -0.527 | 0.527 |
| 135 | GLY | 215 | PRO | 1.260 | 0.738 | 0.521 | 0.521 |
| 179 | PHE | 233 | ALA | 4.432 | 4.954 | -0.521 | 0.521 |
| 245 | MET | 252 | LEU | 6.043 | 5.526 | 0.517 | 0.517 |
| 123 | LEU | 141 | ALA | 2.124 | 2.637 | -0.513 | 0.513 |
| 192 | LEU | 289 | THR | 1.411 | 0.900 | 0.512 | 0.512 |
| 6 | SER | 102 | TYR | 0.000 | 0.509 | -0.509 | 0.509 |
| 151 | ILE | 379 | SER | 1.723 | 2.228 | -0.505 | 0.505 |
| 154 | ASP | 372 | ILE | 1.263 | 0.761 | 0.502 | 0.502 |
| 98 | GLU | 102 | TYR | 0.731 | 0.230 | 0.501 | 0.501 |
| 342 | SER | 343 | ARG | 0.498 | 0.000 | 0.498 | 0.498 |
| 67 | ALA | 68 | PRO | 1.630 | 2.128 | -0.498 | 0.498 |
| 64 | ARG | 65 | SER | 0.899 | 0.407 | 0.492 | 0.492 |
| 166 | ASP | 252 | LEU | 0.000 | 0.492 | -0.492 | 0.492 |
| 154 | ASP | 181 | GLN | 4.371 | 4.859 | -0.487 | 0.487 |
| 174 | CYS | 255 | CYS | 7.297 | 7.783 | -0.486 | 0.486 |
| 378 | ASN | 382 | ASN | 0.000 | 0.485 | -0.485 | 0.485 |
| 258 | HIS | 259 | PRO | 2.803 | 3.287 | -0.484 | 0.484 |
| 151 | ILE | 380 | CYS | 0.694 | 0.213 | 0.481 | 0.481 |
| 348 | THR | 349 | LEU | 1.227 | 0.747 | 0.481 | 0.481 |
| 199 | ARG | 328 | LEU | 0.478 | 0.000 | 0.478 | 0.478 |
| 245 | MET | 254 | ILE | 0.477 | 0.000 | 0.477 | 0.477 |
| 404 | TRP | 407 | SER | 0.473 | 0.000 | 0.473 | 0.473 |
| 44 | GLU | 256 | LEU | 0.000 | 0.472 | -0.472 | 0.472 |
| 148 | LEU | 152 | VAL | 0.467 | 0.000 | 0.467 | 0.467 |
| 214 | VAL | 219 | ALA | 0.487 | 0.022 | 0.465 | 0.465 |
| 60 | ALA | 61 | SER | 0.789 | 1.253 | -0.463 | 0.463 |
| 300 | MET | 315 | LEU | 0.000 | 0.456 | -0.456 | 0.456 |
| 96 | ILE | 100 | PHE | 1.356 | 1.806 | -0.450 | 0.450 |
| 119 | ASN | 144 | ALA | 4.257 | 3.808 | 0.449 | 0.449 |
| 275 | TRP | 278 | PHE | 0.000 | 0.447 | -0.447 | 0.447 |
| 239 | GLY | 257 | LEU | 4.354 | 3.909 | 0.446 | 0.446 |
| 139 | LEU | 198 | ASP | 0.445 | 0.000 | 0.445 | 0.445 |
| 150 | HIS | 379 | SER | 1.197 | 0.753 | 0.445 | 0.445 |
| 139 | LEU | 225 | ILE | 0.012 | 0.455 | -0.443 | 0.443 |
| 12 | LEU | 155 | ILE | 0.000 | 0.438 | -0.438 | 0.438 |
| 247 | TYR | 252 | LEU | 0.437 | 0.000 | 0.437 | 0.437 |
| 173 | MET | 177 | VAL | 0.000 | 0.436 | -0.436 | 0.436 |
| 88 | PRO | 352 | GLN | 0.000 | 0.436 | -0.436 | 0.436 |
| 123 | LEU | 148 | LEU | 0.358 | 0.792 | -0.434 | 0.434 |
| 308 | GLN | 309 | ILE | 0.430 | 0.000 | 0.430 | 0.430 |
| 138 | ILE | 214 | VAL | 0.587 | 1.016 | -0.429 | 0.429 |
| 178 | PRO | 240 | PHE | 4.831 | 4.403 | 0.428 | 0.428 |
| 186 | GLY | 281 | TYR | 2.252 | 2.677 | -0.425 | 0.425 |
| 277 | LEU | 281 | TYR | 1.970 | 1.546 | 0.424 | 0.424 |
| 296 | MET | 300 | MET | 1.227 | 0.806 | 0.421 | 0.421 |
| 166 | ASP | 168 | PRO | 0.264 | 0.681 | -0.417 | 0.417 |
| 123 | LEU | 144 | ALA | 0.885 | 1.301 | -0.417 | 0.417 |
| 192 | LEU | 382 | ASN | 0.414 | 0.000 | 0.414 | 0.414 |
| 398 | LYS | 403 | CYS | 0.000 | 0.414 | -0.414 | 0.414 |
| 182 | LYS | 233 | ALA | 0.821 | 1.234 | -0.413 | 0.413 |
| 338 | PRO | 374 | MET | 0.000 | 0.413 | -0.413 | 0.413 |
| 63 | ALA | 64 | ARG | 0.000 | 0.412 | -0.412 | 0.412 |
| 242 | ILE | 254 | ILE | 2.379 | 2.790 | -0.411 | 0.411 |
| 173 | MET | 176 | LEU | 0.050 | 0.460 | -0.410 | 0.410 |
| 275 | TRP | 347 | LEU | 1.517 | 1.107 | 0.410 | 0.410 |
| 320 | GLU | 323 | LYS | 4.295 | 3.886 | 0.409 | 0.409 |
| 258 | HIS | 270 | LYS | 0.707 | 0.298 | 0.409 | 0.409 |
| 44 | GLU | 343 | ARG | 0.000 | 0.406 | -0.406 | 0.406 |
| 111 | VAL | 373 | ASN | 0.488 | 0.083 | 0.405 | 0.405 |
| 280 | PHE | 285 | PRO | 2.070 | 2.475 | -0.404 | 0.404 |
| 158 | ASN | 372 | ILE | 3.212 | 2.809 | 0.403 | 0.403 |
| 218 | THR | 221 | GLU | 0.000 | 0.402 | -0.402 | 0.402 |
| 119 | ASN | 379 | SER | 2.514 | 2.913 | -0.399 | 0.399 |
| 274 | ASP | 344 | ILE | 0.060 | 0.458 | -0.397 | 0.397 |
| 142 | SER | 191 | SER | 0.828 | 0.431 | 0.397 | 0.397 |
| 278 | PHE | 340 | HIS | 4.910 | 4.519 | 0.391 | 0.391 |
| 34 | ASP | 35 | ARG | 0.391 | 0.000 | 0.391 | 0.391 |
| 132 | MET | 396 | CYS | 0.000 | 0.387 | -0.387 | 0.387 |
| 140 | ILE | 393 | PHE | 0.219 | 0.605 | -0.386 | 0.386 |
| 149 | LEU | 153 | ILE | 0.385 | 0.000 | 0.385 | 0.385 |
| 335 | CYS | 381 | ILE | 0.194 | 0.576 | -0.382 | 0.382 |
| 281 | TYR | 340 | HIS | 0.381 | 0.000 | 0.381 | 0.381 |
| 235 | PRO | 265 | PHE | 0.232 | 0.609 | -0.377 | 0.377 |
| 186 | GLY | 229 | SER | 3.759 | 4.135 | -0.376 | 0.376 |
| 42 | THR | 43 | ALA | 0.371 | 0.000 | 0.371 | 0.371 |
| 126 | ILE | 138 | ILE | 0.076 | 0.446 | -0.371 | 0.371 |
| 334 | LEU | 374 | MET | 0.371 | 0.000 | 0.371 | 0.371 |
| 107 | VAL | 373 | ASN | 1.033 | 1.399 | -0.367 | 0.367 |
| 175 | LYS | 238 | ILE | 0.000 | 0.366 | -0.366 | 0.366 |
| 175 | LYS | 236 | GLU | 0.641 | 0.277 | 0.365 | 0.365 |
| 301 | LEU | 319 | ARG | 0.362 | 0.000 | 0.362 | 0.362 |
| 160 | TYR | 165 | GLU | 0.299 | 0.659 | -0.360 | 0.360 |
| 122 | LEU | 140 | ILE | 0.935 | 1.292 | -0.357 | 0.357 |
| 130 | LYS | 212 | ILE | 0.000 | 0.354 | -0.354 | 0.354 |
| 268 | PHE | 271 | THR | 0.350 | 0.000 | 0.350 | 0.350 |
| 179 | PHE | 236 | GLU | 0.642 | 0.987 | -0.346 | 0.346 |
| 108 | SER | 373 | ASN | 6.803 | 6.459 | 0.344 | 0.344 |
| 299 | GLU | 302 | ARG | 6.506 | 6.163 | 0.343 | 0.343 |
| 94 | ILE | 365 | LEU | 0.653 | 0.994 | -0.341 | 0.341 |
| 243 | ILE | 252 | LEU | 0.905 | 1.246 | -0.340 | 0.340 |
| 16 | VAL | 152 | VAL | 0.000 | 0.340 | -0.340 | 0.340 |
| 179 | PHE | 234 | VAL | 1.118 | 1.454 | -0.336 | 0.336 |
| 126 | ILE | 141 | ALA | 1.937 | 1.601 | 0.336 | 0.336 |
| 9 | GLY | 109 | CYS | 0.000 | 0.335 | -0.335 | 0.335 |
| 140 | ILE | 386 | LEU | 0.943 | 1.278 | -0.335 | 0.335 |
| 112 | PHE | 156 | PRO | 1.813 | 1.482 | 0.332 | 0.332 |
| 196 | SER | 197 | ILE | 0.329 | 0.000 | 0.329 | 0.329 |
| 172 | GLU | 175 | LYS | 0.326 | 0.000 | 0.326 | 0.326 |
| 93 | PRO | 362 | SER | 0.260 | 0.583 | -0.323 | 0.323 |
| 363 | PHE | 367 | LEU | 0.620 | 0.297 | 0.323 | 0.323 |
| 394 | LYS | 395 | ASN | 0.000 | 0.323 | -0.323 | 0.323 |
| 125 | ILE | 396 | CYS | 4.474 | 4.151 | 0.323 | 0.323 |
| 335 | CYS | 377 | LEU | 0.000 | 0.321 | -0.321 | 0.321 |
| 332 | PHE | 378 | ASN | 3.705 | 3.387 | 0.318 | 0.318 |
| 126 | ILE | 393 | PHE | 0.175 | 0.492 | -0.317 | 0.317 |
| 118 | GLY | 383 | PRO | 3.770 | 4.086 | -0.316 | 0.316 |
| 187 | ILE | 226 | TRP | 5.948 | 5.632 | 0.316 | 0.316 |
| 89 | PRO | 355 | PRO | 0.000 | 0.315 | -0.315 | 0.315 |
| 104 | ASN | 108 | SER | 1.057 | 0.742 | 0.315 | 0.315 |
| 138 | ILE | 222 | ILE | 1.663 | 1.978 | -0.314 | 0.314 |
| 152 | VAL | 153 | ILE | 0.000 | 0.314 | -0.314 | 0.314 |
| 189 | VAL | 285 | PRO | 1.611 | 1.924 | -0.313 | 0.313 |
| 139 | LEU | 191 | SER | 0.000 | 0.313 | -0.313 | 0.313 |
| 387 | TYR | 398 | LYS | 0.227 | 0.537 | -0.310 | 0.310 |
| 190 | LEU | 280 | PHE | 0.309 | 0.000 | 0.309 | 0.309 |
| 345 | LEU | 367 | LEU | 0.203 | 0.510 | -0.307 | 0.307 |
| 127 | TYR | 128 | LYS | 0.000 | 0.306 | -0.306 | 0.306 |
| 87 | PRO | 357 | ARG | 0.065 | 0.370 | -0.305 | 0.305 |
| 122 | LEU | 397 | PHE | 1.882 | 2.187 | -0.305 | 0.305 |
| 328 | LEU | 381 | ILE | 0.297 | 0.000 | 0.297 | 0.297 |
| 245 | MET | 247 | TYR | 0.296 | 0.000 | 0.296 | 0.296 |
| 112 | PHE | 152 | VAL | 0.276 | 0.569 | -0.293 | 0.293 |
| 210 | LYS | 215 | PRO | 0.000 | 0.290 | -0.290 | 0.290 |
| 157 | ILE | 161 | LYS | 0.000 | 0.289 | -0.289 | 0.289 |
| 401 | LEU | 402 | CYS | 0.000 | 0.287 | -0.287 | 0.287 |
| 52 | THR | 54 | TRP | 0.000 | 0.282 | -0.282 | 0.282 |
| 126 | ILE | 140 | ILE | 0.842 | 0.562 | 0.280 | 0.280 |
| 174 | CYS | 242 | ILE | 1.375 | 1.100 | 0.275 | 0.275 |
| 351 | ASN | 353 | ASN | 1.662 | 1.936 | -0.274 | 0.274 |
| 424 | LYS | 428 | HIS | 0.000 | 0.273 | -0.273 | 0.273 |
| 431 | ASP | 432 | ASN | 0.272 | 0.000 | 0.272 | 0.272 |
| 327 | CYS | 389 | VAL | 0.000 | 0.272 | -0.272 | 0.272 |
| 49 | PRO | 84 | THR | 0.268 | 0.000 | 0.268 | 0.268 |
| 296 | MET | 297 | THR | 0.268 | 0.000 | 0.268 | 0.268 |
| 335 | CYS | 374 | MET | 7.960 | 8.227 | -0.267 | 0.267 |
| 171 | ALA | 241 | ASP | 0.145 | 0.412 | -0.267 | 0.267 |
| 121 | THR | 400 | CYS | 0.541 | 0.807 | -0.265 | 0.265 |
| 160 | TYR | 169 | PHE | 4.440 | 4.178 | 0.261 | 0.261 |
| 3 | PRO | 316 | LYS | 0.261 | 0.000 | 0.261 | 0.261 |
| 403 | CYS | 406 | GLN | 0.261 | 0.000 | 0.261 | 0.261 |
| 40 | LEU | 161 | LYS | 0.000 | 0.260 | -0.260 | 0.260 |
| 176 | LEU | 180 | ILE | 2.092 | 2.345 | -0.254 | 0.254 |
| 130 | LYS | 133 | ARG | 0.000 | 0.252 | -0.252 | 0.252 |
| 399 | SER | 403 | CYS | 0.251 | 0.000 | 0.251 | 0.251 |
| 199 | ARG | 202 | ALA | 0.000 | 0.251 | -0.251 | 0.251 |
| 397 | PHE | 402 | CYS | 0.000 | 0.251 | -0.251 | 0.251 |
| 258 | HIS | 260 | VAL | 1.231 | 1.481 | -0.250 | 0.250 |
| 317 | GLN | 321 | VAL | 0.249 | 0.000 | 0.249 | 0.249 |
| 201 | ARG | 206 | TRP | 0.249 | 0.000 | 0.249 | 0.249 |
| 201 | ARG | 205 | SER | 0.249 | 0.000 | 0.249 | 0.249 |
| 139 | LEU | 222 | ILE | 1.382 | 1.630 | -0.248 | 0.248 |
| 354 | ASP | 357 | ARG | 0.000 | 0.247 | -0.247 | 0.247 |
| 135 | GLY | 218 | THR | 2.596 | 2.350 | 0.246 | 0.246 |
| 111 | VAL | 377 | LEU | 1.646 | 1.886 | -0.240 | 0.240 |
| 203 | VAL | 296 | MET | 1.885 | 2.124 | -0.240 | 0.240 |
| 132 | MET | 392 | ARG | 6.140 | 6.379 | -0.239 | 0.239 |
| 273 | LYS | 277 | LEU | 1.532 | 1.293 | 0.239 | 0.239 |
| 339 | LEU | 375 | ALA | 0.103 | 0.342 | -0.239 | 0.239 |
| 207 | SER | 208 | ARG | 0.238 | 0.000 | 0.238 | 0.238 |
| 129 | ASN | 132 | MET | 1.052 | 1.290 | -0.238 | 0.238 |
| 45 | ILE | 94 | ILE | 0.000 | 0.238 | -0.238 | 0.238 |
| 174 | CYS | 240 | PHE | 2.956 | 3.192 | -0.236 | 0.236 |
| 195 | LEU | 293 | TYR | 0.236 | 0.000 | 0.236 | 0.236 |
| 140 | ILE | 195 | LEU | 1.048 | 0.813 | 0.235 | 0.235 |
| 134 | ASN | 214 | VAL | 0.234 | 0.000 | 0.234 | 0.234 |
| 190 | LEU | 228 | VAL | 0.631 | 0.864 | -0.233 | 0.233 |
| 125 | ILE | 393 | PHE | 0.333 | 0.100 | 0.232 | 0.232 |
| 47 | THR | 48 | PRO | 0.412 | 0.179 | 0.232 | 0.232 |
| 345 | LEU | 364 | LEU | 0.990 | 0.760 | 0.230 | 0.230 |
| 41 | GLN | 358 | CYS | 0.000 | 0.230 | -0.230 | 0.230 |
| 351 | ASN | 354 | ASP | 0.406 | 0.636 | -0.230 | 0.230 |
| 147 | ASP | 379 | SER | 11.941 | 11.713 | 0.228 | 0.228 |
| 345 | LEU | 349 | LEU | 0.614 | 0.841 | -0.226 | 0.226 |
| 236 | GLU | 273 | LYS | 5.944 | 6.169 | -0.225 | 0.225 |
| 397 | PHE | 401 | LEU | 0.000 | 0.225 | -0.225 | 0.225 |
| 115 | GLY | 148 | LEU | 0.091 | 0.315 | -0.225 | 0.225 |
| 169 | PHE | 173 | MET | 1.014 | 1.237 | -0.223 | 0.223 |
| 360 | LEU | 364 | LEU | 1.597 | 1.819 | -0.222 | 0.222 |
| 233 | ALA | 281 | TYR | 0.000 | 0.220 | -0.220 | 0.220 |
| 335 | CYS | 371 | GLY | 0.535 | 0.316 | 0.219 | 0.219 |
| 387 | TYR | 388 | LEU | 1.285 | 1.066 | 0.219 | 0.219 |
| 105 | THR | 162 | LEU | 0.204 | 0.422 | -0.218 | 0.218 |
| 32 | PRO | 33 | PRO | 1.081 | 0.864 | 0.218 | 0.218 |
| 174 | CYS | 256 | LEU | 0.279 | 0.495 | -0.216 | 0.216 |
| 243 | ILE | 253 | ARG | 1.264 | 1.481 | -0.216 | 0.216 |
| 355 | PRO | 356 | ASN | 0.287 | 0.073 | 0.214 | 0.214 |
| 311 | LEU | 315 | LEU | 1.449 | 1.658 | -0.209 | 0.209 |
| 336 | TRP | 339 | LEU | 0.323 | 0.531 | -0.208 | 0.208 |
| 158 | ASN | 161 | LYS | 0.000 | 0.206 | -0.206 | 0.206 |
| 116 | ILE | 120 | SER | 0.501 | 0.296 | 0.205 | 0.205 |
| 190 | LEU | 229 | SER | 0.882 | 1.084 | -0.202 | 0.202 |
| 19 | CYS | 377 | LEU | 0.200 | 0.000 | 0.200 | 0.200 |
| 37 | THR | 38 | PRO | 1.074 | 0.877 | 0.198 | 0.198 |
| 187 | ILE | 229 | SER | 4.513 | 4.316 | 0.198 | 0.198 |
| 257 | LEU | 270 | LYS | 1.616 | 1.421 | 0.196 | 0.196 |
| 126 | ILE | 132 | MET | 0.697 | 0.892 | -0.195 | 0.195 |
| 189 | VAL | 281 | TYR | 1.599 | 1.793 | -0.194 | 0.194 |
| 9 | GLY | 105 | THR | 0.000 | 0.192 | -0.192 | 0.192 |
| 191 | SER | 195 | LEU | 0.192 | 0.000 | 0.192 | 0.192 |
| 2 | GLN | 36 | ALA | 0.000 | 0.192 | -0.192 | 0.192 |
| 89 | PRO | 357 | ARG | 1.373 | 1.187 | 0.185 | 0.185 |
| 161 | LYS | 255 | CYS | 0.000 | 0.185 | -0.185 | 0.185 |
| 126 | ILE | 137 | ASN | 1.739 | 1.923 | -0.184 | 0.184 |
| 381 | ILE | 385 | ALA | 0.035 | 0.217 | -0.182 | 0.182 |
| 200 | TYR | 292 | PHE | 4.307 | 4.489 | -0.182 | 0.182 |
| 122 | LEU | 144 | ALA | 0.791 | 0.609 | 0.182 | 0.182 |
| 122 | LEU | 386 | LEU | 1.153 | 1.335 | -0.182 | 0.182 |
| 6 | SER | 8 | CYS | 0.124 | 0.304 | -0.179 | 0.179 |
| 222 | ILE | 226 | TRP | 0.940 | 1.119 | -0.179 | 0.179 |
| 229 | SER | 281 | TYR | 0.000 | 0.178 | -0.178 | 0.178 |
| 232 | LEU | 280 | PHE | 2.302 | 2.480 | -0.178 | 0.178 |
| 291 | PHE | 295 | LEU | 3.230 | 3.054 | 0.176 | 0.176 |
| 394 | LYS | 398 | LYS | 0.300 | 0.465 | -0.165 | 0.165 |
| 241 | ASP | 255 | CYS | 1.371 | 1.207 | 0.165 | 0.165 |
| 363 | PHE | 364 | LEU | 0.428 | 0.264 | 0.164 | 0.164 |
| 38 | PRO | 95 | GLU | 0.000 | 0.162 | -0.162 | 0.162 |
| 122 | LEU | 393 | PHE | 1.307 | 1.466 | -0.159 | 0.159 |
| 205 | SER | 318 | ARG | 0.000 | 0.158 | -0.158 | 0.158 |
| 292 | PHE | 295 | LEU | 0.025 | 0.182 | -0.157 | 0.157 |
| 241 | ASP | 258 | HIS | 0.600 | 0.445 | 0.156 | 0.156 |
| 327 | CYS | 385 | ALA | 0.000 | 0.155 | -0.155 | 0.155 |
| 277 | LEU | 340 | HIS | 2.758 | 2.913 | -0.155 | 0.155 |
| 324 | THR | 328 | LEU | 0.000 | 0.155 | -0.155 | 0.155 |
| 258 | HIS | 261 | GLN | 0.777 | 0.622 | 0.155 | 0.155 |
| 119 | ASN | 122 | LEU | 0.000 | 0.154 | -0.154 | 0.154 |
| 105 | THR | 159 | VAL | 0.435 | 0.587 | -0.152 | 0.152 |
| 196 | SER | 329 | VAL | 0.000 | 0.151 | -0.151 | 0.151 |
| 121 | THR | 397 | PHE | 2.360 | 2.210 | 0.150 | 0.150 |
| 256 | LEU | 259 | PRO | 0.362 | 0.510 | -0.148 | 0.148 |
| 338 | PRO | 371 | GLY | 0.961 | 0.813 | 0.148 | 0.148 |
| 194 | ALA | 225 | ILE | 0.665 | 0.518 | 0.148 | 0.148 |
| 150 | HIS | 375 | ALA | 0.463 | 0.316 | 0.147 | 0.147 |
| 107 | VAL | 111 | VAL | 0.148 | 0.295 | -0.147 | 0.147 |
| 28 | GLU | 29 | ARG | 0.145 | 0.000 | 0.145 | 0.145 |
| 100 | PHE | 370 | ILE | 1.648 | 1.503 | 0.145 | 0.145 |
| 167 | TRP | 177 | VAL | 0.393 | 0.535 | -0.142 | 0.142 |
| 103 | ILE | 107 | VAL | 0.184 | 0.045 | 0.139 | 0.139 |
| 335 | CYS | 336 | TRP | 0.124 | 0.261 | -0.137 | 0.137 |
| 200 | TYR | 201 | ARG | 0.000 | 0.136 | -0.136 | 0.136 |
| 104 | ASN | 370 | ILE | 0.247 | 0.383 | -0.136 | 0.136 |
| 183 | ALA | 230 | VAL | 0.402 | 0.538 | -0.136 | 0.136 |
| 240 | PHE | 273 | LYS | 1.699 | 1.565 | 0.134 | 0.134 |
| 377 | LEU | 380 | CYS | 0.080 | 0.213 | -0.132 | 0.132 |
| 349 | LEU | 360 | LEU | 1.777 | 1.645 | 0.132 | 0.132 |
| 357 | ARG | 358 | CYS | 0.167 | 0.038 | 0.128 | 0.128 |
| 214 | VAL | 218 | THR | 0.422 | 0.550 | -0.127 | 0.127 |
| 386 | LEU | 393 | PHE | 2.792 | 2.666 | 0.126 | 0.126 |
| 218 | THR | 222 | ILE | 0.471 | 0.345 | 0.126 | 0.126 |
| 313 | ASP | 316 | LYS | 0.000 | 0.125 | -0.125 | 0.125 |
| 243 | ILE | 256 | LEU | 1.359 | 1.483 | -0.124 | 0.124 |
| 413 | SER | 414 | LEU | 0.123 | 0.000 | 0.123 | 0.123 |
| 374 | MET | 377 | LEU | 0.179 | 0.301 | -0.123 | 0.123 |
| 122 | LEU | 126 | ILE | 0.941 | 1.063 | -0.121 | 0.121 |
| 177 | VAL | 178 | PRO | 1.273 | 1.394 | -0.121 | 0.121 |
| 321 | VAL | 325 | VAL | 0.120 | 0.000 | 0.120 | 0.120 |
| 150 | HIS | 155 | ILE | 0.147 | 0.267 | -0.120 | 0.120 |
| 393 | PHE | 397 | PHE | 1.027 | 0.907 | 0.120 | 0.120 |
| 101 | LYS | 165 | GLU | 2.449 | 2.567 | -0.118 | 0.118 |
| 350 | TYR | 360 | LEU | 1.005 | 0.887 | 0.118 | 0.118 |
| 335 | CYS | 375 | ALA | 2.502 | 2.385 | 0.117 | 0.117 |
| 278 | PHE | 344 | ILE | 0.231 | 0.348 | -0.117 | 0.117 |
| 413 | SER | 417 | LYS | 0.116 | 0.000 | 0.116 | 0.116 |
| 101 | LYS | 163 | LEU | 0.000 | 0.116 | -0.116 | 0.116 |
| 300 | MET | 322 | ALA | 0.116 | 0.000 | 0.116 | 0.116 |
| 167 | TRP | 254 | ILE | 0.000 | 0.115 | -0.115 | 0.115 |
| 183 | ALA | 233 | ALA | 1.630 | 1.745 | -0.114 | 0.114 |
| 203 | VAL | 299 | GLU | 0.821 | 0.707 | 0.114 | 0.114 |
| 280 | PHE | 284 | LEU | 1.245 | 1.359 | -0.113 | 0.113 |
| 345 | LEU | 348 | THR | 0.113 | 0.001 | 0.111 | 0.111 |
| 4 | PRO | 5 | PRO | 0.701 | 0.594 | 0.107 | 0.107 |
| 180 | ILE | 184 | SER | 0.531 | 0.637 | -0.106 | 0.106 |
| 119 | ASN | 151 | ILE | 0.387 | 0.489 | -0.103 | 0.103 |
| 301 | LEU | 318 | ARG | 0.102 | 0.000 | 0.102 | 0.102 |
| 383 | PRO | 397 | PHE | 1.677 | 1.779 | -0.102 | 0.102 |
| 131 | CYS | 132 | MET | 0.243 | 0.345 | -0.102 | 0.102 |
| 113 | VAL | 117 | ILE | 0.779 | 0.679 | 0.100 | 0.100 |
| 271 | THR | 272 | ALA | 0.100 | 0.000 | 0.100 | 0.100 |
| 171 | ALA | 242 | ILE | 2.957 | 3.055 | -0.098 | 0.098 |
| 344 | ILE | 347 | LEU | 0.000 | 0.098 | -0.098 | 0.098 |
| 136 | PRO | 137 | ASN | 0.000 | 0.098 | -0.098 | 0.098 |
| 282 | PHE | 333 | ALA | 2.048 | 2.145 | -0.097 | 0.097 |
| 244 | THR | 253 | ARG | 0.377 | 0.474 | -0.097 | 0.097 |
| 188 | THR | 332 | PHE | 0.000 | 0.097 | -0.097 | 0.097 |
| 361 | LEU | 365 | LEU | 0.000 | 0.097 | -0.097 | 0.097 |
| 328 | LEU | 385 | ALA | 0.681 | 0.586 | 0.095 | 0.095 |
| 154 | ASP | 158 | ASN | 4.253 | 4.158 | 0.095 | 0.095 |
| 159 | VAL | 163 | LEU | 0.677 | 0.771 | -0.095 | 0.095 |
| 257 | LEU | 273 | LYS | 0.759 | 0.665 | 0.095 | 0.095 |
| 206 | TRP | 318 | ARG | 0.000 | 0.094 | -0.094 | 0.094 |
| 86 | SER | 87 | PRO | 0.566 | 0.660 | -0.093 | 0.093 |
| 294 | THR | 298 | CYS | 0.213 | 0.305 | -0.091 | 0.091 |
| 129 | ASN | 131 | CYS | 0.352 | 0.442 | -0.090 | 0.090 |
| 38 | PRO | 96 | ILE | 0.000 | 0.089 | -0.089 | 0.089 |
| 97 | LYS | 100 | PHE | 0.106 | 0.018 | 0.088 | 0.088 |
| 37 | THR | 165 | GLU | 0.000 | 0.088 | -0.088 | 0.088 |
| 288 | ILE | 292 | PHE | 0.986 | 1.073 | -0.087 | 0.087 |
| 345 | LEU | 350 | TYR | 0.509 | 0.423 | 0.086 | 0.086 |
| 250 | SER | 252 | LEU | 0.085 | 0.000 | 0.085 | 0.085 |
| 315 | LEU | 318 | ARG | 0.000 | 0.084 | -0.084 | 0.084 |
| 372 | ILE | 376 | SER | 0.071 | 0.154 | -0.083 | 0.083 |
| 24 | ILE | 25 | TRP | 0.082 | 0.000 | 0.082 | 0.082 |
| 221 | GLU | 225 | ILE | 0.416 | 0.336 | 0.081 | 0.081 |
| 108 | SER | 159 | VAL | 1.395 | 1.476 | -0.081 | 0.081 |
| 234 | VAL | 238 | ILE | 0.885 | 0.965 | -0.080 | 0.080 |
| 242 | ILE | 253 | ARG | 0.618 | 0.698 | -0.080 | 0.080 |
| 286 | LEU | 332 | PHE | 0.934 | 1.014 | -0.080 | 0.080 |
| 109 | CYS | 113 | VAL | 0.078 | 0.000 | 0.078 | 0.078 |
| 117 | ILE | 401 | LEU | 0.078 | 0.000 | 0.078 | 0.078 |
| 319 | ARG | 320 | GLU | 0.000 | 0.077 | -0.077 | 0.077 |
| 114 | LEU | 380 | CYS | 0.212 | 0.135 | 0.077 | 0.077 |
| 388 | LEU | 389 | VAL | 0.108 | 0.031 | 0.077 | 0.077 |
| 193 | CYS | 289 | THR | 0.933 | 0.857 | 0.076 | 0.076 |
| 146 | GLY | 187 | ILE | 0.438 | 0.362 | 0.075 | 0.075 |
| 282 | PHE | 283 | CYS | 0.362 | 0.437 | -0.075 | 0.075 |
| 225 | ILE | 229 | SER | 0.230 | 0.305 | -0.075 | 0.075 |
| 15 | LEU | 377 | LEU | 0.075 | 0.000 | 0.075 | 0.075 |
| 96 | ILE | 101 | LYS | 2.784 | 2.710 | 0.074 | 0.074 |
| 279 | SER | 285 | PRO | 0.000 | 0.073 | -0.073 | 0.073 |
| 337 | LEU | 338 | PRO | 0.974 | 1.047 | -0.073 | 0.073 |
| 262 | LYS | 263 | THR | 0.042 | 0.115 | -0.073 | 0.073 |
| 342 | SER | 364 | LEU | 2.670 | 2.597 | 0.073 | 0.073 |
| 325 | VAL | 329 | VAL | 0.000 | 0.072 | -0.072 | 0.072 |
| 16 | VAL | 21 | LEU | 0.000 | 0.071 | -0.071 | 0.071 |
| 23 | ARG | 24 | ILE | 0.000 | 0.071 | -0.071 | 0.071 |
| 236 | GLU | 277 | LEU | 0.000 | 0.071 | -0.071 | 0.071 |
| 104 | ASN | 162 | LEU | 2.074 | 2.003 | 0.070 | 0.070 |
| 274 | ASP | 347 | LEU | 2.425 | 2.355 | 0.070 | 0.070 |
| 128 | LYS | 129 | ASN | 0.000 | 0.069 | -0.069 | 0.069 |
| 273 | LYS | 274 | ASP | 0.200 | 0.269 | -0.069 | 0.069 |
| 243 | ILE | 259 | PRO | 1.206 | 1.137 | 0.068 | 0.068 |
| 412 | GLN | 415 | GLU | 0.000 | 0.068 | -0.068 | 0.068 |
| 286 | LEU | 329 | VAL | 0.880 | 0.948 | -0.068 | 0.068 |
| 142 | SER | 226 | TRP | 2.878 | 2.945 | -0.067 | 0.067 |
| 137 | ASN | 140 | ILE | 0.529 | 0.463 | 0.066 | 0.066 |
| 90 | CYS | 358 | CYS | 5.255 | 5.190 | 0.065 | 0.065 |
| 195 | LEU | 325 | VAL | 0.000 | 0.065 | -0.065 | 0.065 |
| 185 | VAL | 189 | VAL | 0.245 | 0.310 | -0.064 | 0.064 |
| 344 | ILE | 348 | THR | 0.311 | 0.374 | -0.064 | 0.064 |
| 265 | PHE | 269 | TYR | 0.000 | 0.064 | -0.064 | 0.064 |
| 278 | PHE | 279 | SER | 0.064 | 0.000 | 0.064 | 0.064 |
| 189 | VAL | 190 | LEU | 0.184 | 0.247 | -0.063 | 0.063 |
| 241 | ASP | 254 | ILE | 1.021 | 0.959 | 0.062 | 0.062 |
| 234 | VAL | 235 | PRO | 0.973 | 1.035 | -0.062 | 0.062 |
| 118 | GLY | 397 | PHE | 0.449 | 0.510 | -0.061 | 0.061 |
| 241 | ASP | 256 | LEU | 5.206 | 5.266 | -0.060 | 0.060 |
| 182 | LYS | 229 | SER | 0.000 | 0.058 | -0.058 | 0.058 |
| 173 | MET | 178 | PRO | 0.340 | 0.282 | 0.058 | 0.058 |
| 416 | GLU | 419 | SER | 0.139 | 0.082 | 0.057 | 0.057 |
| 382 | ASN | 383 | PRO | 0.962 | 1.017 | -0.055 | 0.055 |
| 3 | PRO | 4 | PRO | 0.583 | 0.638 | -0.055 | 0.055 |
| 282 | PHE | 336 | TRP | 1.198 | 1.253 | -0.055 | 0.055 |
| 351 | ASN | 352 | GLN | 0.000 | 0.054 | -0.054 | 0.054 |
| 146 | GLY | 226 | TRP | 0.000 | 0.054 | -0.054 | 0.054 |
| 237 | ALA | 238 | ILE | 0.054 | 0.000 | 0.054 | 0.054 |
| 111 | VAL | 376 | SER | 2.270 | 2.216 | 0.054 | 0.054 |
| 223 | VAL | 227 | VAL | 0.302 | 0.250 | 0.052 | 0.052 |
| 116 | ILE | 121 | THR | 0.077 | 0.025 | 0.052 | 0.052 |
| 227 | VAL | 231 | VAL | 0.255 | 0.203 | 0.051 | 0.051 |
| 285 | PRO | 290 | ALA | 0.051 | 0.000 | 0.051 | 0.051 |
| 327 | CYS | 331 | VAL | 0.100 | 0.151 | -0.051 | 0.051 |
| 214 | VAL | 215 | PRO | 0.721 | 0.671 | 0.050 | 0.050 |
| 324 | THR | 390 | SER | 0.000 | 0.049 | -0.049 | 0.049 |
| 115 | GLY | 120 | SER | 0.060 | 0.011 | 0.049 | 0.049 |
| 139 | LEU | 195 | LEU | 1.713 | 1.762 | -0.048 | 0.048 |
| 21 | LEU | 24 | ILE | 0.000 | 0.048 | -0.048 | 0.048 |
| 41 | GLN | 247 | TYR | 0.000 | 0.047 | -0.047 | 0.047 |
| 235 | PRO | 266 | MET | 2.687 | 2.734 | -0.047 | 0.047 |
| 284 | LEU | 285 | PRO | 1.339 | 1.292 | 0.047 | 0.047 |
| 121 | THR | 125 | ILE | 0.598 | 0.644 | -0.046 | 0.046 |
| 386 | LEU | 397 | PHE | 0.063 | 0.018 | 0.045 | 0.045 |
| 345 | LEU | 363 | PHE | 0.045 | 0.000 | 0.045 | 0.045 |
| 242 | ILE | 255 | CYS | 0.044 | 0.000 | 0.044 | 0.044 |
| 370 | ILE | 374 | MET | 0.314 | 0.357 | -0.043 | 0.043 |
| 240 | PHE | 258 | HIS | 0.020 | 0.061 | -0.042 | 0.042 |
| 240 | PHE | 255 | CYS | 0.677 | 0.636 | 0.041 | 0.041 |
| 200 | TYR | 299 | GLU | 0.040 | 0.000 | 0.040 | 0.040 |
| 238 | ILE | 261 | GLN | 0.000 | 0.039 | -0.039 | 0.039 |
| 9 | GLY | 163 | LEU | 0.000 | 0.039 | -0.039 | 0.039 |
| 387 | TYR | 393 | PHE | 0.015 | 0.054 | -0.039 | 0.039 |
| 385 | ALA | 390 | SER | 0.079 | 0.118 | -0.038 | 0.038 |
| 410 | GLU | 413 | SER | 0.043 | 0.081 | -0.038 | 0.038 |
| 12 | LEU | 381 | ILE | 0.037 | 0.000 | 0.037 | 0.037 |
| 241 | ASP | 242 | ILE | 0.086 | 0.123 | -0.037 | 0.037 |
| 188 | THR | 192 | LEU | 0.168 | 0.204 | -0.036 | 0.036 |
| 176 | LEU | 179 | PHE | 0.380 | 0.344 | 0.035 | 0.035 |
| 244 | THR | 252 | LEU | 2.308 | 2.274 | 0.034 | 0.034 |
| 239 | GLY | 258 | HIS | 2.570 | 2.604 | -0.034 | 0.034 |
| 407 | SER | 408 | PHE | 0.043 | 0.010 | 0.033 | 0.033 |
| 274 | ASP | 277 | LEU | 0.141 | 0.173 | -0.032 | 0.032 |
| 360 | LEU | 363 | PHE | 0.000 | 0.032 | -0.032 | 0.032 |
| 151 | ILE | 156 | PRO | 1.027 | 1.059 | -0.032 | 0.032 |
| 257 | LEU | 261 | GLN | 0.883 | 0.915 | -0.032 | 0.032 |
| 239 | GLY | 266 | MET | 1.587 | 1.555 | 0.031 | 0.031 |
| 87 | PRO | 88 | PRO | 0.621 | 0.590 | 0.031 | 0.031 |
| 366 | VAL | 370 | ILE | 0.580 | 0.609 | -0.029 | 0.029 |
| 339 | LEU | 372 | ILE | 0.785 | 0.757 | 0.028 | 0.028 |
| 193 | CYS | 288 | ILE | 1.910 | 1.883 | 0.027 | 0.027 |
| 361 | LEU | 364 | LEU | 0.000 | 0.026 | -0.026 | 0.026 |
| 41 | GLN | 42 | THR | 0.304 | 0.278 | 0.026 | 0.026 |
| 150 | HIS | 336 | TRP | 0.171 | 0.145 | 0.026 | 0.026 |
| 39 | LEU | 40 | LEU | 0.025 | 0.000 | 0.025 | 0.025 |
| 81 | PRO | 82 | PRO | 0.697 | 0.672 | 0.025 | 0.025 |
| 346 | LYS | 350 | TYR | 0.075 | 0.050 | 0.024 | 0.024 |
| 157 | ILE | 158 | ASN | 0.024 | 0.000 | 0.024 | 0.024 |
| 106 | VAL | 110 | LEU | 0.210 | 0.234 | -0.024 | 0.024 |
| 197 | ILE | 288 | ILE | 0.024 | 0.000 | 0.024 | 0.024 |
| 236 | GLU | 269 | TYR | 4.740 | 4.761 | -0.022 | 0.022 |
| 390 | SER | 393 | PHE | 3.141 | 3.162 | -0.021 | 0.021 |
| 88 | PRO | 89 | PRO | 0.615 | 0.636 | -0.021 | 0.021 |
| 119 | ASN | 380 | CYS | 0.000 | 0.021 | -0.021 | 0.021 |
| 245 | MET | 250 | SER | 1.328 | 1.348 | -0.020 | 0.020 |
| 96 | ILE | 162 | LEU | 0.733 | 0.753 | -0.020 | 0.020 |
| 187 | ILE | 191 | SER | 0.428 | 0.408 | 0.020 | 0.020 |
| 129 | ASN | 396 | CYS | 0.350 | 0.369 | -0.019 | 0.019 |
| 48 | PRO | 49 | PRO | 0.633 | 0.614 | 0.019 | 0.019 |
| 179 | PHE | 230 | VAL | 1.906 | 1.923 | -0.017 | 0.017 |
| 155 | ILE | 156 | PRO | 1.199 | 1.216 | -0.017 | 0.017 |
| 239 | GLY | 256 | LEU | 0.380 | 0.397 | -0.017 | 0.017 |
| 276 | TRP | 277 | LEU | 0.679 | 0.663 | 0.016 | 0.016 |
| 43 | ALA | 44 | GLU | 0.016 | 0.000 | 0.016 | 0.016 |
| 105 | THR | 109 | CYS | 0.000 | 0.015 | -0.015 | 0.015 |
| 179 | PHE | 180 | ILE | 0.700 | 0.715 | -0.015 | 0.015 |
| 186 | GLY | 191 | SER | 0.035 | 0.020 | 0.015 | 0.015 |
| 386 | LEU | 394 | LYS | 0.087 | 0.101 | -0.014 | 0.014 |
| 193 | CYS | 285 | PRO | 1.749 | 1.762 | -0.013 | 0.013 |
| 167 | TRP | 168 | PRO | 0.177 | 0.164 | 0.013 | 0.013 |
| 390 | SER | 392 | ARG | 0.610 | 0.597 | 0.013 | 0.013 |
| 104 | ASN | 369 | TYR | 3.495 | 3.482 | 0.013 | 0.013 |
| 155 | ILE | 372 | ILE | 0.013 | 0.000 | 0.013 | 0.013 |
| 43 | ALA | 245 | MET | 0.000 | 0.012 | -0.012 | 0.012 |
| 155 | ILE | 159 | VAL | 0.380 | 0.392 | -0.012 | 0.012 |
| 80 | SER | 81 | PRO | 0.639 | 0.651 | -0.012 | 0.012 |
| 161 | LYS | 369 | TYR | 1.944 | 1.932 | 0.012 | 0.012 |
| 215 | PRO | 217 | TRP | 0.000 | 0.012 | -0.012 | 0.012 |
| 46 | MET | 270 | LYS | 0.000 | 0.011 | -0.011 | 0.011 |
| 331 | VAL | 335 | CYS | 0.395 | 0.385 | 0.010 | 0.010 |
| 263 | THR | 265 | PHE | 0.308 | 0.317 | -0.009 | 0.009 |
| 228 | VAL | 232 | LEU | 0.947 | 0.956 | -0.008 | 0.008 |
| 225 | ILE | 226 | TRP | 0.119 | 0.127 | -0.008 | 0.008 |
| 2 | GLN | 3 | PRO | 0.553 | 0.545 | 0.008 | 0.008 |
| 257 | LEU | 269 | TYR | 0.123 | 0.129 | -0.007 | 0.007 |
| 35 | ARG | 37 | THR | 0.000 | 0.006 | -0.006 | 0.006 |
| 286 | LEU | 291 | PHE | 0.006 | 0.000 | 0.006 | 0.006 |
| 196 | SER | 289 | THR | 2.951 | 2.956 | -0.005 | 0.005 |
| 143 | LEU | 188 | THR | 3.150 | 3.155 | -0.005 | 0.005 |
| 99 | THR | 103 | ILE | 0.394 | 0.390 | 0.004 | 0.004 |
| 154 | ASP | 155 | ILE | 0.000 | 0.003 | -0.003 | 0.003 |
| 245 | MET | 251 | TYR | 1.353 | 1.351 | 0.002 | 0.002 |
| 339 | LEU | 342 | SER | 0.002 | 0.000 | 0.002 | 0.002 |
| 384 | ILE | 388 | LEU | 0.700 | 0.699 | 0.001 | 0.001 |
| 117 | ILE | 121 | THR | 0.307 | 0.306 | 0.001 | 0.001 |
| 9 | GLY | 159 | VAL | 0.000 | 0.001 | -0.001 | 0.001 |
| 112 | PHE | 113 | VAL | 0.098 | 0.099 | -0.001 | 0.001 |
| 125 | ILE | 129 | ASN | 0.777 | 0.777 | 0.000 | 0.000 |
RRCS change distribution
-0.33
Mean ΔRRCS
1.61
Std Dev
-0.09
Median
Magnitude classification
17
High (|Δ| ≥ 5.0)
62
Medium (2.3 ≤ |Δ| < 5.0)
723
Low (|Δ| < 2.3)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.26, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar