GP149

Gene GPR149 Class A orphans Orphan receptors UniProt Q86SP6

UniProt ↗ GPCRdb ↗ NCBI Gene ↗

1139

Total Contact Pairs

152

Significant Changes

9.40

Max Increase

-11.06

Max Decrease

Interactive snake plot

GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.

Color convention: blue = active-favoring, red = inactive-favoring.

Top 100 conformational changes

Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.

Rank	Residue 1	Residue 2	Active RRCS	Inactive RRCS	ΔRRCS	Magnitude
1	TRP323 (6.48x48)	THR351 (7.42x41)	0.072	11.128	-11.056	HIGH
2	TRP172	SER187	9.401	0.000	+9.401	HIGH
3	PHE554	VAL621	0.000	8.396	-8.396	HIGH
4	VAL558	ILE617	0.000	8.156	-8.156	HIGH
5	LEU560	VAL615	0.000	8.114	-8.114	HIGH
6	GLU623	ARG656	0.000	7.952	-7.952	HIGH
7	GLY556	LEU619	0.000	7.835	-7.835	HIGH
8	VAL575	SER635	0.000	7.724	-7.724	HIGH
9	ASN120 (3.40x40)	TYR198 (5.43x44)	1.595	9.151	-7.555	HIGH
10	CYS552	GLU623	0.000	7.343	-7.343	HIGH
11	TYR129 (3.49x49)	ARG146	0.000	7.313	-7.313	HIGH
12	ASP78 (2.50x50)	THR355 (7.46x46)	0.406	7.438	-7.032	HIGH
13	PHE37 (1.36x36)	MET89 (2.61x61)	0.000	7.007	-7.007	HIGH
14	GLU512	ARG513	6.985	0.000	+6.985	HIGH
15	LEU59 (1.58x58)	ARG64	0.233	6.745	-6.513	HIGH
16	PHE449	ASN450	0.000	6.443	-6.443	HIGH
17	TYR417	TYR418	6.352	12.619	-6.266	HIGH
18	HIS428	ASN429	0.000	6.244	-6.244	HIGH
19	ASN501	TYR502	6.162	0.000	+6.162	HIGH
20	SER433	GLU434	0.000	6.129	-6.129	HIGH
21	VAL176	LEU183 (45.51x51)	0.000	5.943	-5.943	HIGH
22	ALA562	THR613	0.000	5.898	-5.898	HIGH
23	ASP444	ASN445	0.526	6.378	-5.852	HIGH
24	LEU216 (5.61x61)	ARG310 (6.35x35)	0.000	5.848	-5.848	HIGH
25	ASP494	LYS495	12.900	7.144	+5.756	HIGH
26	HIS329 (6.54x54)	GLN333 (6.58x58)	7.644	1.908	+5.736	HIGH
27	TYR112 (3.32x32)	TRP323 (6.48x48)	0.000	5.692	-5.692	HIGH
28	PHE88 (2.60x60)	CYS182 (45.50x50)	0.796	6.486	-5.690	HIGH
29	CYS186	GLN333 (6.58x58)	0.000	5.494	-5.494	HIGH
30	TYR573	ILE637	0.000	5.490	-5.490	HIGH
31	TYR100 (3.20x20)	LEU104 (3.24x24)	0.000	5.476	-5.476	HIGH
32	MET80 (2.52x52)	GLN115 (3.35x35)	7.460	2.010	+5.450	HIGH
33	VAL138	ARG224	0.000	5.446	-5.446	HIGH
34	ALA307 (6.32x32)	TRP367	5.548	0.147	+5.401	HIGH
35	PHE311 (6.36x36)	SER364 (7.55x55)	0.000	5.338	-5.338	HIGH
36	SER526	ASP527	5.336	0.000	+5.336	HIGH
37	THR133 (3.53x53)	LYS309 (6.34x34)	0.000	5.305	-5.305	HIGH
38	SER271	ASP272	6.213	0.953	+5.259	HIGH
39	THR65	PRO371	5.257	0.000	+5.257	HIGH
40	CYS186	ASN334 (6.59x59)	0.000	5.147	-5.147	HIGH
41	GLU220	LYS309 (6.34x34)	5.026	0.000	+5.026	HIGH
42	LEU117 (3.37x37)	TYR198 (5.43x44)	4.967	0.000	+4.967	MED
43	VAL191 (5.36x37)	ASN334 (6.59x59)	5.857	1.001	+4.856	MED
44	THR474	ASN475	0.000	4.808	-4.808	MED
45	ASN130 (3.50x50)	LYS309 (6.34x34)	0.000	4.750	-4.750	MED
46	CYS186	TYR190 (5.35x36)	4.736	0.000	+4.736	MED
47	THR178	ASP185	4.694	0.000	+4.694	MED
48	GLN333 (6.58x58)	GLN339	0.125	4.809	-4.684	MED
49	VAL71 (2.43x43)	PHE361 (7.52x52)	0.000	4.679	-4.679	MED
50	SER638	LEU652	1.649	6.260	-4.611	MED
51	GLY116 (3.36x36)	TYR198 (5.43x44)	4.585	0.000	+4.585	MED
52	LEU167 (4.59x59)	TRP172	0.000	4.553	-4.553	MED
53	VAL274	PHE275	0.000	4.525	-4.525	MED
54	ASP632	LYS657	0.000	4.505	-4.505	MED
55	TYR198 (5.43x44)	VAL320 (6.45x45)	0.000	4.486	-4.486	MED
56	LYS319 (6.44x44)	ALA354 (7.45x45)	0.000	4.439	-4.439	MED
57	PRO168 (4.60x60)	GLY173	0.000	4.419	-4.419	MED
58	ASN95	PHE101 (3.21x21)	0.000	4.411	-4.411	MED
59	GLN442	ARG443	0.904	5.277	-4.373	MED
60	THR65	GLN308 (6.33x33)	0.000	4.333	-4.333	MED
61	HIS135 (3.55x55)	ARG215 (5.60x60)	7.404	11.731	-4.327	MED
62	SER364 (7.55x55)	TRP367	4.324	0.000	+4.324	MED
63	PHE675	ASN686	6.622	2.301	+4.321	MED
64	GLN555	TYR573	4.316	0.000	+4.316	MED
65	MET134 (3.54x54)	LYS309 (6.34x34)	0.000	4.290	-4.290	MED
66	TRP180	LEU341 (7.32x31)	0.000	4.285	-4.285	MED
67	PRO325 (6.50x50)	SER347 (7.38x37)	0.000	4.268	-4.268	MED
68	GLN115 (3.35x35)	TRP323 (6.48x48)	0.000	4.266	-4.266	MED
69	ASP185	SER187	0.000	4.263	-4.263	MED
70	MET431	ASN432	0.000	4.222	-4.222	MED
71	LEU551	SER576	4.202	0.000	+4.202	MED
72	GLU590	TYR592	0.210	4.382	-4.171	MED
73	PHE88 (2.60x60)	SER108 (3.28x28)	1.098	5.264	-4.166	MED
74	LEU113 (3.33x33)	TYR198 (5.43x44)	4.155	0.000	+4.155	MED
75	ASP477	ILE478	4.147	0.000	+4.147	MED
76	ARG537	TYR592	0.000	4.144	-4.144	MED
77	GLN467	ARG468	1.556	5.662	-4.105	MED
78	GLN339	GLU344 (7.35x34)	6.151	2.070	+4.081	MED
79	ASN445	ARG446	4.031	8.092	-4.061	MED
80	LYS587	ASP626	0.000	4.050	-4.050	MED
81	ASN120 (3.40x40)	LYS319 (6.44x44)	4.042	0.000	+4.042	MED
82	PHE675	ASP684	1.906	5.839	-3.933	MED
83	GLN703	TYR710	6.653	10.574	-3.921	MED
84	LEU462	ASP463	0.283	4.174	-3.890	MED
85	GLU422	ASN423	3.399	7.266	-3.868	MED
86	TYR672	ASP691	3.655	7.498	-3.843	MED
87	GLN555	GLU620	0.000	3.811	-3.811	MED
88	LYS522	ASP524	0.000	3.778	-3.778	MED
89	LYS472	CYS473	0.000	3.756	-3.756	MED
90	HIS329 (6.54x54)	LEU343 (7.34x33)	5.129	1.437	+3.692	MED
91	ASN21	SER22	0.000	3.675	-3.675	MED
92	ALA174	ASP185	0.140	3.808	-3.668	MED
93	ASP77 (2.49x49)	GLN115 (3.35x35)	0.930	4.583	-3.653	MED
94	TRP74 (2.46x46)	SER119 (3.39x39)	8.487	4.882	+3.605	MED
95	SER571	ASN639	0.011	3.602	-3.591	MED
96	ILE470	ASN471	0.000	3.556	-3.556	MED
97	MET61 (1.60x60)	LYS365	0.000	3.543	-3.543	MED
98	ILE314 (6.39x39)	PHE361 (7.52x52)	3.527	0.000	+3.527	MED
99	ASN11	ASP12	9.203	5.694	+3.509	MED
100	GLN308 (6.33x33)	PHE361 (7.52x52)	0.000	3.508	-3.508	MED

Transmembrane domain analysis

Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.76 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).

Segment	Range	Active-favoring residues	Count	Inactive-favoring residues	Count
TM1	37-61	-	0	37 (-7.0), 59 (-6.5), 61 (-3.5)	3
TM2	66-89	80 (5.4), 74 (3.6), 73 (3.2)	3	78 (-7.0), 89 (-7.0), 88 (-5.7), 71 (-4.7), 77 (-3.7), 66 (-3.4)	6
TM3	100-135	115 (5.4), 117 (5.0), 116 (4.6), 113 (4.2), 119 (3.6), 111 (3.4), 122 (3.2), 118 (3.2)	8	120 (-7.6), 129 (-7.3), 112 (-5.7), 100 (-5.5), 104 (-5.5), 133 (-5.3), 130 (-4.8), 101 (-4.4), 135 (-4.3), 134 (-4.3), 108 (-4.2), 109 (-3.5), 105 (-3.3), 124 (-3.1)	14
TM4	158-168	-	0	167 (-4.6), 168 (-4.4), 158 (-3.5), 164 (-3.2)	4
TM5	190-216	191 (4.9), 190 (4.7)	2	198 (-7.6), 216 (-5.8), 215 (-4.3), 192 (-3.5), 201 (-3.1)	5
TM6	307-334	329 (5.7), 333 (5.7), 307 (5.4), 314 (3.5), 315 (3.1)	5	323 (-11.1), 310 (-5.8), 311 (-5.3), 309 (-5.3), 334 (-5.1), 320 (-4.5), 319 (-4.4), 308 (-4.3), 325 (-4.3), 322 (-3.1)	10
TM7	341-364	344 (4.1), 343 (3.7)	2	351 (-11.1), 355 (-7.0), 364 (-5.3), 361 (-4.7), 354 (-4.4), 341 (-4.3), 347 (-4.3), 345 (-3.2), 350 (-3.1), 358 (-3.0)	10
Intracellular / Extracellular loops & H8
ICL1	64-65	65 (5.3)	1	64 (-6.5)	1
ICL2	138-146	-	0	146 (-7.3), 138 (-5.4)	2
ICL3	220-275	271 (5.3), 272 (5.3), 220 (5.0)	3	224 (-5.4), 274 (-4.5), 275 (-4.5)	3
ECL1	95-95	-	0	95 (-4.4)	1
ECL2	172-187	172 (9.4), 187 (9.4), 178 (4.7), 185 (4.7)	4	176 (-5.9), 183 (-5.9), 182 (-5.7), 186 (-5.5), 173 (-4.4), 180 (-4.3), 174 (-3.7), 175 (-3.5)	8
ECL3	339-339	-	0	339 (-4.7)	1
H8	-	-	0	-	0

Interactive visualizations

ΔRRCS distribution

Active vs inactive comparison

Residue-wise changes

TM domain breakdown

Variants of interest

270 variants mapped to contact positions, sorted by |ΔRRCS| impact.

Position	Protein change	DNA change	Allele freq	Het / Hom	ΔRRCS	AM score	Pathogenicity	Conservation	dbSNP
323	p.Trp323Arg	c.967T>C	6.85e-07	1 / 0	11.06	0.975	PATHOGENIC	0.97	rs1712376244
172	p.Trp172Cys	c.516G>C	6.84e-06	10 / 0	9.40	0.897	PATHOGENIC	0.94
187	p.Ser187Phe	c.560C>T	8.21e-06	12 / 0	9.40	0.180	BENIGN	0.57	rs764115711
187	p.Ser187Pro	c.559T>C	6.84e-07	1 / 0	9.40	-	nan	-	rs753249682
172	p.Trp172Leu	c.515G>T	6.84e-07	1 / 0	9.40	-	nan	-	rs777899912
621	p.Val621Ile	c.1861G>A	6.84e-07	1 / 0	8.40	0.291	BENIGN	1.00	rs1451307301
617	p.Ile617Thr	c.1850T>C	1.37e-06	2 / 0	8.16	0.994	PATHOGENIC	1.00	rs1713697249
558	p.Val558Met	c.1672G>A	6.85e-07	1 / 0	8.16	0.872	PATHOGENIC	0.96	rs1352248660
656	p.Arg656Thr	c.1967G>C	2.05e-06	3 / 0	7.95	0.969	PATHOGENIC	1.00	rs772231938
656	p.Arg656Gly	c.1966A>G	1.37e-06	2 / 0	7.95	-	nan	-	rs1175827943
619	p.Leu619Trp	c.1856T>G	6.84e-07	1 / 0	7.83	0.984	PATHOGENIC	1.00
619	p.Leu619Met	c.1855T>A	6.84e-07	1 / 0	7.83	-	nan	-
120	p.Asn120Lys	c.360C>A	6.84e-07	1 / 0	7.56	0.944	PATHOGENIC	0.96
198	p.Tyr198His	c.592T>C	6.84e-07	1 / 0	7.56	0.703	PATHOGENIC	0.91	rs1712400035
120	p.Asn120Tyr	c.358A>T	3.42e-06	5 / 0	7.56	-	nan	-	rs1559993907
552	p.Cys552Tyr	c.1655G>A	6.57e-06	1 / 0	7.34	0.960	PATHOGENIC	0.94	rs1175483169
552	p.Cys552Ser	c.1654T>A	6.94e-07	1 / 0	7.34	-	nan	-
552	p.Cys552Arg	c.1654T>C	3.47e-06	5 / 0	7.34	-	nan	-	rs761431313
129	p.Tyr129Cys	c.386A>G	6.84e-07	1 / 0	7.31	0.287	BENIGN	0.99
146	p.Arg146Ser	c.438A>T	6.84e-07	1 / 0	7.31	0.150	BENIGN	0.81	rs766067244
146	p.Arg146Thr	c.437G>C	6.84e-07	1 / 0	7.31	-	nan	-
78	p.Asp78Glu	c.234T>A	6.84e-07	1 / 0	7.03	0.907	PATHOGENIC	1.00	rs773865104
355	p.Thr355Ser	c.1064C>G	6.84e-07	1 / 0	7.03	0.123	BENIGN	0.59
78	p.Asp78Val	c.233A>T	6.84e-07	1 / 0	7.03	-	nan	-
78	p.Asp78Tyr	c.232G>T	6.84e-07	1 / 0	7.03	-	nan	-
78	p.Asp78His	c.232G>C	1.37e-06	2 / 0	7.03	-	nan	-
37	p.Phe37Leu	c.111T>A	6.84e-07	1 / 0	7.01	0.792	PATHOGENIC	0.96
89	p.Met89Thr	c.266T>C	1.23e-05	18 / 0	7.01	0.293	BENIGN	0.91	rs750489757
89	p.Met89Leu	c.265A>T	6.36e-05	91 / 1	7.01	-	nan	-	rs758606538
89	p.Met89Val	c.265A>G	2.05e-06	3 / 0	7.01	-	nan	-	rs758606538
512	p.Glu512Val	c.1535A>T	6.58e-06	1 / 0	6.99	0.288	BENIGN	0.94
450	p.Asn450Ser	c.1349A>G	6.84e-07	1 / 0	6.44	0.059	BENIGN	0.48	rs770565253
450	p.Asn450Asp	c.1348A>G	1.37e-06	2 / 0	6.44	-	nan	-	rs778459121
417	p.Tyr417Cys	c.1250A>G	6.86e-07	1 / 0	6.27	0.076	BENIGN	0.64
418	p.Tyr418Cys	c.1253A>G	2.06e-06	3 / 0	6.27	0.063	BENIGN	0.68	rs777285501
429	p.Asn429Lys	c.1287C>A	1.37e-06	2 / 0	6.24	0.247	BENIGN	0.82	rs767291931
428	p.His428Leu	c.1283A>T	6.58e-06	1 / 0	6.24	0.129	BENIGN	0.89	rs777707427
429	p.Asn429Ser	c.1286A>G	4.11e-06	6 / 0	6.24	-	nan	-	rs190883894
429	p.Asn429Ile	c.1286A>T	3.77e-05	55 / 0	6.24	-	nan	-	rs190883894
428	p.His428Arg	c.1283A>G	6.85e-07	1 / 0	6.24	-	nan	-	rs777707427
428	p.His428Tyr	c.1282C>T	2.05e-06	3 / 0	6.24	-	nan	-
428	p.His428Asp	c.1282C>G	6.59e-06	1 / 0	6.24	-	nan	-	rs1379461833
502	p.Tyr502Asp	c.1504T>G	6.84e-07	1 / 0	6.16	0.068	BENIGN	0.60
501	p.Asn501Ser	c.1502A>G	3.42e-06	5 / 0	6.16	0.068	BENIGN	0.60	rs1365223733
434	p.Glu434Lys	c.1300G>A	3.42e-06	5 / 0	6.13	0.086	BENIGN	0.72	rs1482440946
434	p.Glu434Gln	c.1300G>C	6.84e-07	1 / 0	6.13	-	nan	-	rs1482440946
176	p.Val176Ala	c.527T>C	6.84e-07	1 / 0	5.94	0.179	BENIGN	0.65
176	p.Val176Leu	c.526G>C	2.05e-06	3 / 0	5.94	-	nan	-
176	p.Val176Leu	c.526G>T	6.84e-07	1 / 0	5.94	-	nan	-	rs1238895826
562	p.Ala562Val	c.1685C>T	6.57e-06	1 / 0	5.90	0.628	PATHOGENIC	0.96	rs1423380268
613	p.Thr613Ser	c.1837A>T	2.05e-06	3 / 0	5.90	0.180	BENIGN	0.97	rs757683127
562	p.Ala562Pro	c.1684G>C	2.05e-06	3 / 0	5.90	-	nan	-
444	p.Asp444Val	c.1331A>T	6.84e-07	1 / 0	5.85	0.123	BENIGN	0.72	rs1712138164
444	p.Asp444Asn	c.1330G>A	3.42e-05	50 / 0	5.85	-	nan	-	rs1397569038
216	p.Leu216Phe	c.648G>T	1.31e-05	2 / 0	5.85	0.429	AMBIGUOUS	0.96	rs1576935043
310	p.Arg310His	c.929G>A	6.84e-07	1 / 0	5.85	0.405	AMBIGUOUS	0.98	rs1338314187
310	p.Arg310Ser	c.928C>A	1.57e-05	23 / 0	5.85	-	nan	-	rs560059695
310	p.Arg310Gly	c.928C>G	2.74e-06	4 / 0	5.85	-	nan	-	rs560059695
494	p.Asp494Glu	c.1482C>A	1.37e-06	2 / 0	5.76	0.080	BENIGN	0.52	rs1277758216
333	p.Gln333Pro	c.998A>C	6.85e-07	1 / 0	5.74	0.251	BENIGN	0.76	rs1234859652
329	p.His329Leu	c.986A>T	6.86e-07	1 / 0	5.74	0.179	BENIGN	0.70	rs1712349022
333	p.Gln333Glu	c.997C>G	8.90e-06	13 / 0	5.74	-	nan	-	rs752410142
112	p.Tyr112Cys	c.335A>G	6.84e-07	1 / 0	5.69	0.788	PATHOGENIC	1.00
112	p.Tyr112Asp	c.334T>G	4.10e-06	6 / 0	5.69	-	nan	-	rs543853324
182	p.Cys182Phe	c.545G>T	6.84e-07	1 / 0	5.69	0.755	PATHOGENIC	0.94	rs1011332591
186	p.Cys186Ser	c.557G>C	6.84e-07	1 / 0	5.49	0.099	BENIGN	0.75	rs764926533
186	p.Cys186Tyr	c.557G>A	1.03e-05	15 / 0	5.49	-	nan	-	rs764926533
637	p.Ile637Asn	c.1910T>A	6.84e-07	1 / 0	5.49	0.918	PATHOGENIC	0.97
573	p.Tyr573Cys	c.1718A>G	1.37e-06	2 / 0	5.49	0.740	PATHOGENIC	1.00
573	p.Tyr573Ser	c.1718A>C	6.84e-07	1 / 0	5.49	-	nan	-	rs768716585
104	p.Leu104Met	c.310C>A	1.37e-06	2 / 0	5.48	0.203	BENIGN	0.99
115	p.Gln115Pro	c.344A>C	6.84e-07	1 / 0	5.45	0.702	PATHOGENIC	1.00
80	p.Met80Leu	c.238A>C	4.10e-06	6 / 0	5.45	0.075	BENIGN	0.67	rs952589424
115	p.Gln115Arg	c.344A>G	6.84e-07	1 / 0	5.45	-	nan	-	rs1475637246
80	p.Met80Leu	c.238A>T	6.84e-07	1 / 0	5.45	-	nan	-	rs952589424
224	p.Arg224Lys	c.671G>A	6.58e-06	1 / 0	5.45	0.115	BENIGN	0.52	rs1218259890
138	p.Val138Ala	c.413T>C	6.84e-07	1 / 0	5.45	0.066	BENIGN	0.54
224	p.Arg224Gly	c.670A>G	3.42e-06	5 / 0	5.45	-	nan	-
138	p.Val138Leu	c.412G>T	6.84e-07	1 / 0	5.45	-	nan	-	rs1712411662
367	p.Trp367Ser	c.1100G>C	2.05e-06	3 / 0	5.40	0.886	PATHOGENIC	1.00
307	p.Ala307Glu	c.920C>A	6.84e-07	1 / 0	5.40	0.730	PATHOGENIC	0.97	rs527609541
307	p.Ala307Val	c.920C>T	6.57e-06	1 / 0	5.40	-	nan	-	rs527609541
364	p.Ser364Phe	c.1091C>T	2.05e-06	3 / 0	5.34	0.931	PATHOGENIC	0.98	rs1449023418
364	p.Ser364Tyr	c.1091C>A	6.84e-07	1 / 0	5.34	-	nan	-
526	p.Ser526Leu	c.1577C>T	6.85e-07	1 / 0	5.34	0.114	BENIGN	0.75	rs1223196216
309	p.Lys309Asn	c.927G>C	6.84e-07	1 / 0	5.31	0.842	PATHOGENIC	0.97	rs757134828
133	p.Thr133Arg	c.398C>G	1.09e-05	16 / 0	5.31	0.202	BENIGN	0.72	rs753849596
133	p.Thr133Lys	c.398C>A	6.84e-07	1 / 0	5.31	-	nan	-	rs753849596
133	p.Thr133Ala	c.397A>G	6.57e-06	1 / 0	5.31	-	nan	-	rs757342527
272	p.Asp272Asn	c.814G>A	6.84e-07	1 / 0	5.26	0.094	BENIGN	0.66	rs1211635673
371	p.Pro371Leu	c.1112C>T	2.05e-06	3 / 0	5.26	0.651	PATHOGENIC	1.00
65	p.Thr65Ser	c.194C>G	6.84e-07	1 / 0	5.26	0.149	BENIGN	0.89
65	p.Thr65Ser	c.193A>T	6.84e-07	1 / 0	5.26	-	nan	-	rs758417625
334	p.Asn334Lys	c.1002C>A	6.85e-07	1 / 0	5.15	0.178	BENIGN	0.75
334	p.Asn334Asp	c.1000A>G	6.85e-07	1 / 0	5.15	-	nan	-
220	p.Glu220Asp	c.660G>T	6.84e-07	1 / 0	5.03	0.107	BENIGN	0.62
220	p.Glu220Lys	c.658G>A	5.47e-06	8 / 0	5.03	-	nan	-	rs761917713
191	p.Val191Leu	c.571G>T	3.42e-06	5 / 0	4.86	0.234	BENIGN	0.71	rs773432335
191	p.Val191Ile	c.571G>A	6.84e-07	1 / 0	4.86	-	nan	-	rs773432335
474	p.Thr474Pro	c.1420A>C	1.37e-06	2 / 0	4.81	0.099	BENIGN	0.63	rs757480859
474	p.Thr474Ala	c.1420A>G	2.74e-06	4 / 0	4.81	-	nan	-	rs757480859
130	p.Asn130Lys	c.390C>G	6.84e-07	1 / 0	4.75	0.951	PATHOGENIC	0.89	rs1249966671
130	p.Asn130Ser	c.389A>G	1.37e-06	2 / 0	4.75	-	nan	-
130	p.Asn130His	c.388A>C	8.89e-06	13 / 0	4.75	-	nan	-	rs758595092
190	p.Tyr190Cys	c.569A>G	6.84e-07	1 / 0	4.74	0.339	BENIGN	0.94
190	p.Tyr190Asn	c.568T>A	6.84e-07	1 / 0	4.74	-	nan	-
185	p.Asp185Glu	c.555C>G	6.84e-07	1 / 0	4.69	0.369	AMBIGUOUS	0.85	rs1712402889
178	p.Thr178Lys	c.533C>A	1.37e-06	2 / 0	4.69	0.180	BENIGN	0.91	rs780542696
185	p.Asp185Ala	c.554A>C	2.05e-06	3 / 0	4.69	-	nan	-	rs1454863227
185	p.Asp185Val	c.554A>T	6.84e-07	1 / 0	4.69	-	nan	-	rs1454863227
178	p.Thr178Met	c.533C>T	4.11e-06	6 / 0	4.69	-	nan	-	rs780542696
339	p.Gln339His	c.1017G>T	6.84e-07	1 / 0	4.68	0.171	BENIGN	0.82
361	p.Phe361Ile	c.1081T>A	3.42e-06	5 / 0	4.68	0.837	PATHOGENIC	0.99
71	p.Val71Ala	c.212T>C	2.26e-05	33 / 0	4.68	0.401	AMBIGUOUS	0.98	rs764439760
71	p.Val71Leu	c.211G>C	6.84e-07	1 / 0	4.68	-	nan	-
652	p.Leu652Arg	c.1955T>G	6.84e-07	1 / 0	4.61	0.988	PATHOGENIC	1.00	rs1383954500
638	p.Ser638Thr	c.1913G>C	6.84e-07	1 / 0	4.61	0.652	PATHOGENIC	1.00
638	p.Ser638Gly	c.1912A>G	6.84e-07	1 / 0	4.61	-	nan	-
116	p.Gly116Asp	c.347G>A	1.37e-06	2 / 0	4.59	0.881	PATHOGENIC	0.98	rs1712415019
116	p.Gly116Cys	c.346G>T	6.84e-07	1 / 0	4.59	-	nan	-
116	p.Gly116Ser	c.346G>A	2.05e-05	30 / 0	4.59	-	nan	-	rs191694043
167	p.Leu167Phe	c.499C>T	6.84e-07	1 / 0	4.55	0.167	BENIGN	0.92	rs1362306279
275	p.Phe275Leu	c.825C>A	2.74e-06	4 / 0	4.52	0.553	AMBIGUOUS	0.69	rs571778012
274	p.Val274Gly	c.821T>G	1.32e-05	2 / 0	4.52	0.071	BENIGN	0.71	rs1487756379
274	p.Val274Leu	c.820G>C	6.84e-07	1 / 0	4.52	-	nan	-	rs1239937857
632	p.Asp632Val	c.1895A>T	3.42e-06	5 / 0	4.51	0.967	PATHOGENIC	1.00	rs755850453
319	p.Lys319Thr	c.956A>C	1.37e-06	2 / 0	4.44	0.881	PATHOGENIC	0.94
354	p.Ala354Thr	c.1060G>A	1.37e-06	2 / 0	4.44	0.535	AMBIGUOUS	0.89	rs1312620334
168	p.Pro168Arg	c.503C>G	2.74e-06	4 / 0	4.42	0.912	PATHOGENIC	0.98	rs760551811
173	p.Gly173Ser	c.517G>A	2.74e-06	4 / 0	4.42	0.465	AMBIGUOUS	0.94	rs769900754
168	p.Pro168Leu	c.503C>T	2.05e-06	3 / 0	4.42	-	nan	-	rs760551811
168	p.Pro168Gln	c.503C>A	1.37e-06	2 / 0	4.42	-	nan	-
101	p.Phe101Leu	c.303C>G	2.05e-06	3 / 0	4.41	0.453	AMBIGUOUS	0.25	rs761033778
95	p.Asn95Asp	c.283A>G	6.84e-07	1 / 0	4.41	0.068	BENIGN	0.54	rs1712418071
443	p.Arg443Thr	c.1328G>C	6.59e-06	1 / 0	4.37	0.082	BENIGN	0.57	rs1047213701
442	p.Gln442Arg	c.1325A>G	6.84e-07	1 / 0	4.37	0.073	BENIGN	0.58
442	p.Gln442Pro	c.1325A>C	2.05e-06	3 / 0	4.37	-	nan	-	rs1048628098
308	p.Gln308Glu	c.922C>G	6.84e-07	1 / 0	4.33	0.177	BENIGN	0.99
135	p.His135Gln	c.405C>A	6.57e-06	1 / 0	4.33	0.134	BENIGN	0.59	rs778286864
215	p.Arg215Gln	c.644G>A	6.84e-07	1 / 0	4.33	0.061	BENIGN	0.77
215	p.Arg215Pro	c.644G>C	6.84e-07	1 / 0	4.33	-	nan	-	rs1485779242
135	p.His135Arg	c.404A>G	1.37e-06	2 / 0	4.33	-	nan	-
135	p.His135Tyr	c.403C>T	6.84e-07	1 / 0	4.33	-	nan	-	rs909702356
686	p.Asn686Thr	c.2057A>C	6.84e-07	1 / 0	4.32	0.186	BENIGN	0.91	rs750341229
134	p.Met134Ile	c.402G>A	6.84e-07	1 / 0	4.29	0.277	BENIGN	0.60
134	p.Met134Thr	c.401T>C	6.84e-07	1 / 0	4.29	-	nan	-	rs1338151449
180	p.Trp180Arg	c.538T>C	2.74e-06	4 / 0	4.29	0.870	PATHOGENIC	0.88	rs758165003
341	p.Leu341Phe	c.1021C>T	6.84e-06	10 / 0	4.29	0.095	BENIGN	0.72	rs375840587
325	p.Pro325Ala	c.973C>G	1.37e-06	2 / 0	4.27	0.662	PATHOGENIC	0.98	rs765673776
347	p.Ser347Asn	c.1040G>A	6.84e-07	1 / 0	4.27	0.538	AMBIGUOUS	0.88
347	p.Ser347Cys	c.1039A>T	6.84e-07	1 / 0	4.27	-	nan	-	rs1712343685
347	p.Ser347Gly	c.1039A>G	1.37e-06	2 / 0	4.27	-	nan	-
431	p.Met431Ile	c.1293G>T	1.44e-05	21 / 0	4.22	0.231	BENIGN	0.57	rs566323770
432	p.Asn432Ser	c.1295A>G	3.42e-06	5 / 0	4.22	0.099	BENIGN	0.70
431	p.Met431Ile	c.1293G>A	6.85e-07	1 / 0	4.22	-	nan	-
431	p.Met431Thr	c.1292T>C	2.05e-06	3 / 0	4.22	-	nan	-	rs1559991252
431	p.Met431Val	c.1291A>G	3.42e-06	5 / 0	4.22	-	nan	-	rs763297214
576	p.Ser576Arg	c.1728C>A	6.84e-07	1 / 0	4.20	0.956	PATHOGENIC	1.00	rs780077517
576	p.Ser576Thr	c.1727G>C	6.84e-07	1 / 0	4.20	-	nan	-	rs945879057
592	p.Tyr592Ser	c.1775A>C	6.84e-07	1 / 0	4.17	0.913	PATHOGENIC	1.00
590	p.Glu590Lys	c.1768G>A	6.57e-06	1 / 0	4.17	0.747	PATHOGENIC	1.00	rs374985361
592	p.Tyr592Cys	c.1775A>G	2.33e-05	34 / 0	4.17	-	nan	-	rs187790328
108	p.Ser108Phe	c.323C>T	6.84e-07	1 / 0	4.17	0.829	PATHOGENIC	0.97	rs1712416173
477	p.Asp477Gly	c.1430A>G	6.84e-07	1 / 0	4.15	0.092	BENIGN	0.62
478	p.Ile478Thr	c.1433T>C	6.84e-07	1 / 0	4.15	0.076	BENIGN	0.48
477	p.Asp477Ala	c.1430A>C	8.21e-06	12 / 0	4.15	-	nan	-
537	p.Arg537Ser	c.1611A>T	1.38e-06	2 / 0	4.14	0.963	PATHOGENIC	0.98
468	p.Arg468Ser	c.1404A>C	2.20e-04	320 / 1	4.11	0.102	BENIGN	0.46	rs148319718
467	p.Gln467Arg	c.1400A>G	6.84e-07	1 / 0	4.11	0.069	BENIGN	0.45
468	p.Arg468Lys	c.1403G>A	2.05e-06	3 / 0	4.11	-	nan	-	rs141747460
468	p.Arg468Thr	c.1403G>C	6.84e-07	1 / 0	4.11	-	nan	-
344	p.Glu344Asp	c.1032G>C	6.84e-07	1 / 0	4.08	0.222	BENIGN	0.84
344	p.Glu344Gly	c.1031A>G	6.84e-07	1 / 0	4.08	-	nan	-
344	p.Glu344Lys	c.1030G>A	1.37e-06	2 / 0	4.08	-	nan	-
446	p.Arg446Leu	c.1337G>T	6.84e-07	1 / 0	4.06	0.095	BENIGN	0.33
446	p.Arg446His	c.1337G>A	5.47e-06	8 / 0	4.06	-	nan	-	rs761233578
446	p.Arg446Ser	c.1336C>A	6.16e-06	9 / 0	4.06	-	nan	-	rs375230371
446	p.Arg446Gly	c.1336C>G	3.42e-06	5 / 0	4.06	-	nan	-	rs375230371
446	p.Arg446Cys	c.1336C>T	2.94e-05	43 / 0	4.06	-	nan	-	rs375230371
587	p.Lys587Arg	c.1760A>G	6.84e-07	1 / 0	4.05	0.099	BENIGN	1.00
587	p.Lys587Met	c.1760A>T	6.84e-07	1 / 0	4.05	-	nan	-	rs1423831039
684	p.Asp684Gly	c.2051A>G	4.79e-06	7 / 0	3.93	0.150	BENIGN	0.91	rs758420110
684	p.Asp684Asn	c.2050G>A	6.84e-07	1 / 0	3.93	-	nan	-	rs779428998
710	p.Tyr710Cys	c.2129A>G	2.05e-06	3 / 0	3.92	0.485	AMBIGUOUS	0.99	rs1264454382
703	p.Gln703Lys	c.2107C>A	6.84e-07	1 / 0	3.92	0.261	BENIGN	1.00	rs1713688690
463	p.Asp463Glu	c.1389C>G	6.84e-07	1 / 0	3.89	0.191	BENIGN	0.81
462	p.Leu462Pro	c.1385T>C	6.84e-07	1 / 0	3.89	0.063	BENIGN	0.44	rs1338101467
463	p.Asp463Ala	c.1388A>C	1.37e-06	2 / 0	3.89	-	nan	-
463	p.Asp463Asn	c.1387G>A	2.05e-06	3 / 0	3.89	-	nan	-	rs1284439046
462	p.Leu462Met	c.1384C>A	3.42e-06	5 / 0	3.89	-	nan	-	rs1039690478
423	p.Asn423Lys	c.1269T>G	2.08e-04	300 / 2	3.87	0.169	BENIGN	0.70	rs182928013
422	p.Glu422Lys	c.1264G>A	2.74e-06	4 / 0	3.87	0.076	BENIGN	0.66	rs1712140928
423	p.Asn423Tyr	c.1267A>T	3.42e-06	5 / 0	3.87	-	nan	-	rs1712140731
691	p.Asp691Glu	c.2073C>G	3.42e-06	5 / 0	3.84	0.916	PATHOGENIC	1.00	rs761628711
620	p.Glu620Gly	c.1859A>G	6.84e-07	1 / 0	3.81	0.967	PATHOGENIC	1.00
524	p.Asp524His	c.1570G>C	3.42e-06	5 / 0	3.78	0.177	BENIGN	0.76	rs774642099
473	p.Cys473Gly	c.1417T>G	1.37e-06	2 / 0	3.76	0.068	BENIGN	0.52
343	p.Leu343Phe	c.1029G>T	6.84e-07	1 / 0	3.69	0.073	BENIGN	0.69	rs766811145
343	p.Leu343Ser	c.1028T>C	6.84e-07	1 / 0	3.69	-	nan	-	rs747837516
343	p.Leu343Trp	c.1028T>G	6.84e-07	1 / 0	3.69	-	nan	-	rs747837516
21	p.Asn21Lys	c.63T>A	6.84e-07	1 / 0	3.67	0.200	BENIGN	0.55
22	p.Ser22Pro	c.64T>C	6.84e-07	1 / 0	3.67	0.127	BENIGN	0.52	rs768230732
21	p.Asn21Ser	c.62A>G	6.57e-06	1 / 0	3.67	-	nan	-	rs1712427112
21	p.Asn21Ile	c.62A>T	6.84e-07	1 / 0	3.67	-	nan	-
21	p.Asn21Asp	c.61A>G	3.42e-06	5 / 0	3.67	-	nan	-
174	p.Ala174Ser	c.520G>T	1.37e-06	2 / 0	3.67	0.070	BENIGN	0.46	rs1223873342
77	p.Asp77Glu	c.231T>G	6.84e-07	1 / 0	3.65	0.923	PATHOGENIC	1.00
77	p.Asp77Gly	c.230A>G	6.84e-06	10 / 0	3.65	-	nan	-	rs373893460
77	p.Asp77Val	c.230A>T	6.16e-05	90 / 0	3.65	-	nan	-	rs373893460
77	p.Asp77Asn	c.229G>A	6.57e-06	1 / 0	3.65	-	nan	-	rs1244639815
74	p.Trp74Cys	c.222G>C	6.57e-06	1 / 0	3.60	0.639	PATHOGENIC	0.56	rs775138006
119	p.Ser119Cys	c.355A>T	6.84e-07	1 / 0	3.60	0.294	BENIGN	0.96	rs1191006125
119	p.Ser119Gly	c.355A>G	6.84e-07	1 / 0	3.60	-	nan	-
571	p.Ser571Pro	c.1711T>C	6.84e-07	1 / 0	3.59	0.985	PATHOGENIC	0.98
470	p.Ile470Thr	c.1409T>C	6.84e-07	1 / 0	3.56	0.135	BENIGN	0.58
471	p.Asn471Ile	c.1412A>T	6.84e-07	1 / 0	3.56	0.119	BENIGN	0.62
470	p.Ile470Val	c.1408A>G	2.74e-06	4 / 0	3.56	-	nan	-	rs751331230
365	p.Lys365Thr	c.1094A>C	6.84e-07	1 / 0	3.54	0.293	BENIGN	0.68
61	p.Met61Ile	c.183G>A	1.37e-06	2 / 0	3.54	0.290	BENIGN	0.79	rs1372831784
61	p.Met61Ile	c.183G>T	6.84e-07	1 / 0	3.54	-	nan	-	rs1372831784
61	p.Met61Leu	c.181A>T	6.84e-07	1 / 0	3.54	-	nan	-
61	p.Met61Val	c.181A>G	1.37e-06	2 / 0	3.54	-	nan	-	rs755288183
61	p.Met61Leu	c.181A>C	6.84e-07	1 / 0	3.54	-	nan	-
314	p.Ile314Val	c.940A>G	6.84e-07	1 / 0	3.53	0.175	BENIGN	0.95
12	p.Asp12Tyr	c.34G>T	6.84e-07	1 / 0	3.51	0.138	BENIGN	0.62	rs773662912
175	p.Phe175Leu	c.525C>A	4.01e-04	586 / 0	3.51	0.970	PATHOGENIC	0.79	rs199943929
109	p.Ala109Val	c.326C>T	4.10e-06	6 / 0	3.51	0.740	PATHOGENIC	0.92	rs1382102694
175	p.Phe175Leu	c.525C>G	3.42e-06	5 / 0	3.51	-	nan	-	rs199943929
175	p.Phe175Ile	c.523T>A	6.84e-07	1 / 0	3.51	-	nan	-	rs779771096
175	p.Phe175Leu	c.523T>C	6.84e-07	1 / 0	3.51	-	nan	-
175	p.Phe175Val	c.523T>G	1.64e-05	24 / 0	3.51	-	nan	-	rs779771096
158	p.Trp158Cys	c.474G>C	1.38e-04	201 / 0	3.48	0.824	PATHOGENIC	1.00	rs370595639
192	p.Leu192Pro	c.575T>C	6.84e-07	1 / 0	3.47	0.124	BENIGN	0.93	rs748288416
192	p.Leu192Val	c.574C>G	6.16e-06	9 / 0	3.47	-	nan	-	rs1305421757
500	p.Ile500Val	c.1498A>G	1.37e-06	2 / 0	3.40	0.063	BENIGN	0.53	rs1303931230
664	p.Cys664Tyr	c.1991G>A	6.85e-07	1 / 0	3.36	0.839	PATHOGENIC	0.97
653	p.Arg653His	c.1958G>A	6.23e-05	91 / 0	3.36	0.542	AMBIGUOUS	1.00	rs200247671
664	p.Cys664Arg	c.1990T>C	1.37e-06	2 / 0	3.36	-	nan	-	rs921290292
653	p.Arg653Pro	c.1958G>C	8.90e-06	13 / 0	3.36	-	nan	-	rs200247671
653	p.Arg653Cys	c.1957C>T	3.22e-05	45 / 1	3.36	-	nan	-	rs764929017
111	p.Met111Ile	c.333G>A	1.37e-05	20 / 0	3.35	0.162	BENIGN	0.75	rs200650973
111	p.Met111Arg	c.332T>G	6.84e-07	1 / 0	3.35	-	nan	-
111	p.Met111Leu	c.331A>T	3.35e-05	49 / 0	3.35	-	nan	-	rs1046116358
105	p.Cys105Tyr	c.314G>A	6.57e-06	1 / 0	3.33	0.877	PATHOGENIC	1.00	rs1341810003
105	p.Cys105Arg	c.313T>C	6.84e-07	1 / 0	3.33	-	nan	-	rs1274681209
612	p.Asp612Gly	c.1835A>G	6.84e-07	1 / 0	3.24	0.477	AMBIGUOUS	1.00	rs1403916571
561	p.His561Arg	c.1682A>G	6.84e-07	1 / 0	3.24	0.181	BENIGN	0.73
612	p.Asp612Asn	c.1834G>A	6.84e-07	1 / 0	3.24	-	nan	-
561	p.His561Tyr	c.1681C>T	6.85e-07	1 / 0	3.24	-	nan	-
122	p.Lys122Asn	c.366G>C	6.84e-07	1 / 0	3.22	0.968	PATHOGENIC	0.94
440	p.Asp440Tyr	c.1318G>T	6.84e-07	1 / 0	3.17	0.088	BENIGN	0.65
441	p.Pro441Leu	c.1322C>T	6.16e-06	9 / 0	3.17	0.072	BENIGN	0.56
441	p.Pro441Thr	c.1321C>A	6.16e-06	9 / 0	3.17	-	nan	-	rs776804882
440	p.Asp440His	c.1318G>C	6.84e-07	1 / 0	3.17	-	nan	-
345	p.Thr345Ala	c.1033A>G	6.57e-06	1 / 0	3.16	0.100	BENIGN	0.67	rs539383644
421	p.Asp421Glu	c.1263T>G	4.11e-06	6 / 0	3.13	0.106	BENIGN	0.78	rs1015113014
421	p.Asp421Gly	c.1262A>G	6.85e-07	1 / 0	3.13	-	nan	-
322	p.Leu322Phe	c.964C>T	6.85e-07	1 / 0	3.09	0.436	AMBIGUOUS	0.97
201	p.Ala201Val	c.602C>T	9.58e-06	14 / 0	3.07	0.185	BENIGN	0.62	rs758822578
124	p.Thr124Ser	c.371C>G	8.21e-06	12 / 0	3.07	0.132	BENIGN	0.65	rs187242792
201	p.Ala201Pro	c.601G>C	6.84e-07	1 / 0	3.07	-	nan	-
124	p.Thr124Ile	c.371C>T	6.57e-06	1 / 0	3.07	-	nan	-	rs187242792
315	p.Leu315Arg	c.944T>G	2.05e-06	3 / 0	3.05	0.912	PATHOGENIC	0.97	rs1356828383
315	p.Leu315Pro	c.944T>C	2.74e-06	4 / 0	3.05	-	nan	-
625	p.Cys625Tyr	c.1874G>A	6.84e-07	1 / 0	3.04	0.923	PATHOGENIC	1.00
550	p.Pro550Leu	c.1649C>T	1.04e-05	15 / 0	3.04	0.875	PATHOGENIC	0.98	rs758883655
358	p.Thr358Ser	c.1073C>G	6.84e-06	10 / 0	3.03	0.533	AMBIGUOUS	0.97	rs754331227
358	p.Thr358Ile	c.1073C>T	6.84e-07	1 / 0	3.03	-	nan	-
358	p.Thr358Asn	c.1073C>A	4.10e-06	6 / 0	3.03	-	nan	-
358	p.Thr358Ala	c.1072A>G	6.84e-07	1 / 0	3.03	-	nan	-	rs757829295

Complete RRCS results

Res1	AA1	Res2	AA2	Active RRCS	Inactive RRCS	ΔRRCS	\|ΔRRCS\|
323	TRP	351	THR	0.072	11.128	-11.056	11.056
172	TRP	187	SER	9.401	0.000	9.401	9.401
554	PHE	621	VAL	0.000	8.396	-8.396	8.396
558	VAL	617	ILE	0.000	8.156	-8.156	8.156
560	LEU	615	VAL	0.000	8.114	-8.114	8.114
623	GLU	656	ARG	0.000	7.952	-7.952	7.952
556	GLY	619	LEU	0.000	7.835	-7.835	7.835
575	VAL	635	SER	0.000	7.724	-7.724	7.724
120	ASN	198	TYR	1.595	9.151	-7.555	7.555
552	CYS	623	GLU	0.000	7.343	-7.343	7.343
129	TYR	146	ARG	0.000	7.313	-7.313	7.313
78	ASP	355	THR	0.406	7.438	-7.032	7.032
37	PHE	89	MET	0.000	7.007	-7.007	7.007
512	GLU	513	ARG	6.985	0.000	6.985	6.985
59	LEU	64	ARG	0.233	6.745	-6.513	6.513
449	PHE	450	ASN	0.000	6.443	-6.443	6.443
417	TYR	418	TYR	6.352	12.619	-6.266	6.266
428	HIS	429	ASN	0.000	6.244	-6.244	6.244
501	ASN	502	TYR	6.162	0.000	6.162	6.162
433	SER	434	GLU	0.000	6.129	-6.129	6.129
176	VAL	183	LEU	0.000	5.943	-5.943	5.943
562	ALA	613	THR	0.000	5.898	-5.898	5.898
444	ASP	445	ASN	0.526	6.378	-5.852	5.852
216	LEU	310	ARG	0.000	5.848	-5.848	5.848
494	ASP	495	LYS	12.900	7.144	5.756	5.756
329	HIS	333	GLN	7.644	1.908	5.736	5.736
112	TYR	323	TRP	0.000	5.692	-5.692	5.692
88	PHE	182	CYS	0.796	6.486	-5.690	5.690
186	CYS	333	GLN	0.000	5.494	-5.494	5.494
573	TYR	637	ILE	0.000	5.490	-5.490	5.490
100	TYR	104	LEU	0.000	5.476	-5.476	5.476
80	MET	115	GLN	7.460	2.010	5.450	5.450
138	VAL	224	ARG	0.000	5.446	-5.446	5.446
307	ALA	367	TRP	5.548	0.147	5.401	5.401
311	PHE	364	SER	0.000	5.338	-5.338	5.338
526	SER	527	ASP	5.336	0.000	5.336	5.336
133	THR	309	LYS	0.000	5.305	-5.305	5.305
271	SER	272	ASP	6.213	0.953	5.259	5.259
65	THR	371	PRO	5.257	0.000	5.257	5.257
186	CYS	334	ASN	0.000	5.147	-5.147	5.147
220	GLU	309	LYS	5.026	0.000	5.026	5.026
117	LEU	198	TYR	4.967	0.000	4.967	4.967
191	VAL	334	ASN	5.857	1.001	4.856	4.856
474	THR	475	ASN	0.000	4.808	-4.808	4.808
130	ASN	309	LYS	0.000	4.750	-4.750	4.750
186	CYS	190	TYR	4.736	0.000	4.736	4.736
178	THR	185	ASP	4.694	0.000	4.694	4.694
333	GLN	339	GLN	0.125	4.809	-4.684	4.684
71	VAL	361	PHE	0.000	4.679	-4.679	4.679
638	SER	652	LEU	1.649	6.260	-4.611	4.611
116	GLY	198	TYR	4.585	0.000	4.585	4.585
167	LEU	172	TRP	0.000	4.553	-4.553	4.553
274	VAL	275	PHE	0.000	4.525	-4.525	4.525
632	ASP	657	LYS	0.000	4.505	-4.505	4.505
198	TYR	320	VAL	0.000	4.486	-4.486	4.486
319	LYS	354	ALA	0.000	4.439	-4.439	4.439
168	PRO	173	GLY	0.000	4.419	-4.419	4.419
95	ASN	101	PHE	0.000	4.411	-4.411	4.411
442	GLN	443	ARG	0.904	5.277	-4.373	4.373
65	THR	308	GLN	0.000	4.333	-4.333	4.333
135	HIS	215	ARG	7.404	11.731	-4.327	4.327
364	SER	367	TRP	4.324	0.000	4.324	4.324
675	PHE	686	ASN	6.622	2.301	4.321	4.321
555	GLN	573	TYR	4.316	0.000	4.316	4.316
134	MET	309	LYS	0.000	4.290	-4.290	4.290
180	TRP	341	LEU	0.000	4.285	-4.285	4.285
325	PRO	347	SER	0.000	4.268	-4.268	4.268
115	GLN	323	TRP	0.000	4.266	-4.266	4.266
185	ASP	187	SER	0.000	4.263	-4.263	4.263
431	MET	432	ASN	0.000	4.222	-4.222	4.222
551	LEU	576	SER	4.202	0.000	4.202	4.202
590	GLU	592	TYR	0.210	4.382	-4.171	4.171
88	PHE	108	SER	1.098	5.264	-4.166	4.166
113	LEU	198	TYR	4.155	0.000	4.155	4.155
477	ASP	478	ILE	4.147	0.000	4.147	4.147
537	ARG	592	TYR	0.000	4.144	-4.144	4.144
467	GLN	468	ARG	1.556	5.662	-4.105	4.105
339	GLN	344	GLU	6.151	2.070	4.081	4.081
445	ASN	446	ARG	4.031	8.092	-4.061	4.061
587	LYS	626	ASP	0.000	4.050	-4.050	4.050
120	ASN	319	LYS	4.042	0.000	4.042	4.042
675	PHE	684	ASP	1.906	5.839	-3.933	3.933
703	GLN	710	TYR	6.653	10.574	-3.921	3.921
462	LEU	463	ASP	0.283	4.174	-3.890	3.890
422	GLU	423	ASN	3.399	7.266	-3.868	3.868
672	TYR	691	ASP	3.655	7.498	-3.843	3.843
555	GLN	620	GLU	0.000	3.811	-3.811	3.811
522	LYS	524	ASP	0.000	3.778	-3.778	3.778
472	LYS	473	CYS	0.000	3.756	-3.756	3.756
329	HIS	343	LEU	5.129	1.437	3.692	3.692
21	ASN	22	SER	0.000	3.675	-3.675	3.675
174	ALA	185	ASP	0.140	3.808	-3.668	3.668
77	ASP	115	GLN	0.930	4.583	-3.653	3.653
74	TRP	119	SER	8.487	4.882	3.605	3.605
571	SER	639	ASN	0.011	3.602	-3.591	3.591
470	ILE	471	ASN	0.000	3.556	-3.556	3.556
61	MET	365	LYS	0.000	3.543	-3.543	3.543
314	ILE	361	PHE	3.527	0.000	3.527	3.527
11	ASN	12	ASP	9.203	5.694	3.509	3.509
308	GLN	361	PHE	0.000	3.508	-3.508	3.508
109	ALA	175	PHE	0.000	3.508	-3.508	3.508
80	MET	158	TRP	0.000	3.478	-3.478	3.478
192	LEU	334	ASN	0.000	3.466	-3.466	3.466
500	ILE	501	ASN	3.403	0.000	3.403	3.403
78	ASP	319	LYS	0.000	3.398	-3.398	3.398
430	LEU	431	MET	0.000	3.369	-3.369	3.369
66	VAL	129	TYR	4.897	8.264	-3.367	3.367
653	ARG	664	CYS	4.259	0.903	3.355	3.355
111	MET	115	GLN	3.350	0.000	3.350	3.350
77	ASP	158	TRP	1.615	4.946	-3.331	3.331
105	CYS	182	CYS	4.194	7.519	-3.325	3.325
560	LEU	568	LEU	4.136	0.836	3.300	3.300
463	ASP	464	SER	0.133	3.388	-3.255	3.255
561	HIS	612	ASP	0.000	3.243	-3.243	3.243
73	SER	122	LYS	6.784	3.561	3.223	3.223
175	PHE	183	LEU	0.000	3.214	-3.214	3.214
77	ASP	118	SER	5.183	1.985	3.199	3.199
440	ASP	441	PRO	3.353	0.179	3.174	3.174
109	ALA	182	CYS	0.000	3.173	-3.173	3.173
180	TRP	345	THR	0.000	3.160	-3.160	3.160
164	LEU	190	TYR	0.000	3.155	-3.155	3.155
421	ASP	422	GLU	0.707	3.840	-3.133	3.133
322	LEU	350	LEU	2.679	5.772	-3.093	3.093
80	MET	111	MET	0.966	4.059	-3.093	3.093
124	THR	201	ALA	1.205	4.278	-3.073	3.073
329	HIS	344	GLU	3.552	6.622	-3.070	3.070
311	PHE	315	LEU	3.055	0.000	3.055	3.055
550	PRO	625	CYS	0.000	3.040	-3.040	3.040
426	PHE	428	HIS	0.000	3.032	-3.032	3.032
78	ASP	358	THR	1.481	4.507	-3.026	3.026
635	SER	653	ARG	0.000	3.024	-3.024	3.024
429	ASN	430	LEU	0.682	3.640	-2.958	2.958
202	PHE	320	VAL	4.216	1.259	2.957	2.957
486	ASN	487	ASN	1.132	4.061	-2.929	2.929
499	ASP	500	ILE	3.801	0.892	2.908	2.908
124	THR	205	LEU	5.120	2.213	2.907	2.907
74	TRP	316	ALA	0.000	2.880	-2.880	2.880
132	TYR	136	ARG	7.374	4.500	2.874	2.874
626	ASP	656	ARG	2.873	0.000	2.873	2.873
55	LEU	75	SER	1.538	4.401	-2.863	2.863
506	THR	507	PHE	2.860	0.000	2.860	2.860
554	PHE	584	PRO	2.853	0.000	2.853	2.853
458	THR	459	THR	0.000	2.847	-2.847	2.847
40	THR	89	MET	0.000	2.836	-2.836	2.836
553	ALA	574	GLU	2.829	0.000	2.829	2.829
319	LYS	323	TRP	2.807	0.000	2.807	2.807
119	SER	319	LYS	4.232	1.431	2.802	2.802
333	GLN	344	GLU	2.798	0.000	2.798	2.798
88	PHE	181	GLY	0.000	2.795	-2.795	2.795
338	PHE	340	SER	0.000	2.790	-2.790	2.790
557	THR	618	HIS	0.000	2.784	-2.784	2.784
315	LEU	361	PHE	0.005	2.769	-2.764	2.764
361	PHE	367	TRP	2.746	0.000	2.746	2.746
489	LYS	490	ASP	13.074	10.343	2.731	2.731
485	SER	486	ASN	3.855	1.146	2.709	2.709
176	VAL	182	CYS	0.000	2.690	-2.690	2.690
436	GLU	437	THR	0.419	3.084	-2.665	2.665
198	TYR	324	LEU	0.000	2.654	-2.654	2.654
120	ASN	323	TRP	2.645	0.000	2.645	2.645
98	PRO	101	PHE	2.627	0.000	2.627	2.627
560	LEU	567	THR	2.616	0.000	2.616	2.616
250	SER	251	LEU	0.000	2.552	-2.552	2.552
315	LEU	357	VAL	0.000	2.543	-2.543	2.543
478	ILE	479	THR	2.541	0.000	2.541	2.541
112	TYR	326	MET	0.194	2.724	-2.530	2.530
134	MET	308	GLN	2.518	0.000	2.518	2.518
101	PHE	177	ARG	0.000	2.499	-2.499	2.499
414	HIS	416	ASP	0.000	2.490	-2.490	2.490
168	PRO	175	PHE	0.000	2.488	-2.488	2.488
648	ARG	668	GLU	0.000	2.460	-2.460	2.460
85	VAL	348	PHE	0.000	2.457	-2.457	2.457
110	LEU	175	PHE	0.000	2.454	-2.454	2.454
227	SER	228	ASN	2.613	0.166	2.447	2.447
177	ARG	182	CYS	0.000	2.428	-2.428	2.428
703	GLN	712	GLU	0.000	2.422	-2.422	2.422
446	ARG	447	ASN	0.000	2.420	-2.420	2.420
565	GLY	613	THR	0.000	2.400	-2.400	2.400
644	SER	647	VAL	0.000	2.398	-2.398	2.398
228	ASN	231	GLU	2.393	0.000	2.393	2.393
502	TYR	503	GLU	3.279	0.904	2.375	2.375
471	ASN	472	LYS	0.607	2.974	-2.367	2.367
62	GLN	381	ASN	2.365	0.000	2.365	2.365
273	THR	274	VAL	0.000	2.363	-2.363	2.363
126	LEU	312	ALA	0.000	2.341	-2.341	2.341
141	GLN	146	ARG	0.000	2.321	-2.321	2.321
561	HIS	614	SER	0.000	2.317	-2.317	2.317
88	PHE	92	GLN	2.314	0.000	2.314	2.314
571	SER	638	SER	0.000	2.308	-2.308	2.308
438	THR	439	LYS	3.430	1.125	2.305	2.305
173	GLY	188	SER	0.000	2.305	-2.305	2.305
54	SER	363	LEU	2.302	0.000	2.302	2.302
475	ASN	476	THR	0.000	2.282	-2.282	2.282
310	ARG	372	CYS	0.000	2.280	-2.280	2.280
318	THR	361	PHE	2.274	0.000	2.274	2.274
491	ALA	492	PHE	3.658	1.386	2.272	2.272
457	SER	458	THR	0.000	2.269	-2.269	2.269
117	LEU	161	SER	4.094	1.833	2.261	2.261
372	CYS	378	CYS	2.257	0.000	2.257	2.257
87	ILE	108	SER	0.484	2.734	-2.251	2.251
663	SER	666	LEU	2.246	0.000	2.246	2.246
357	VAL	361	PHE	2.243	0.000	2.243	2.243
57	SER	365	LYS	0.000	2.234	-2.234	2.234
123	ALA	316	ALA	0.000	2.227	-2.227	2.227
319	LYS	358	THR	0.000	2.225	-2.225	2.225
87	ILE	104	LEU	0.002	2.225	-2.223	2.223
130	ASN	212	LEU	0.065	2.284	-2.220	2.220
118	SER	161	SER	3.956	6.171	-2.216	2.216
311	PHE	367	TRP	3.068	0.857	2.211	2.211
74	TRP	319	LYS	0.419	2.615	-2.196	2.196
432	ASN	433	SER	0.000	2.190	-2.190	2.190
88	PHE	348	PHE	3.488	1.312	2.176	2.176
43	MET	356	THR	3.453	1.277	2.176	2.176
8	LEU	9	SER	0.107	2.276	-2.169	2.169
174	ALA	184	VAL	0.000	2.163	-2.163	2.163
637	ILE	672	TYR	0.000	2.159	-2.159	2.159
54	SER	75	SER	2.757	0.619	2.137	2.137
559	SER	568	LEU	2.120	0.000	2.120	2.120
557	THR	570	LEU	2.117	0.000	2.117	2.117
130	ASN	308	GLN	2.109	0.000	2.109	2.109
553	ALA	621	VAL	0.000	2.105	-2.105	2.105
573	TYR	636	ILE	0.000	2.097	-2.097	2.097
333	GLN	338	PHE	0.088	2.185	-2.097	2.097
450	ASN	451	ALA	0.000	2.091	-2.091	2.091
437	THR	438	THR	4.086	2.007	2.079	2.079
198	TYR	327	MET	2.594	4.667	-2.073	2.073
627	ASN	630	ALA	0.549	2.610	-2.060	2.060
443	ARG	444	ASP	6.888	8.944	-2.057	2.057
636	ILE	654	TYR	0.507	2.558	-2.051	2.051
476	THR	477	ASP	3.064	1.013	2.051	2.051
131	PHE	208	LEU	0.055	2.091	-2.037	2.037
10	THR	11	ASN	2.339	0.316	2.023	2.023
361	PHE	364	SER	0.000	2.022	-2.022	2.022
91	LEU	101	PHE	2.441	4.455	-2.014	2.014
558	VAL	570	LEU	2.012	0.000	2.012	2.012
169	LEU	190	TYR	1.990	0.000	1.990	1.990
84	SER	111	MET	5.318	3.336	1.982	1.982
631	LEU	656	ARG	0.000	1.982	-1.982	1.982
145	ARG	149	GLN	1.974	0.000	1.974	1.974
572	THR	637	ILE	0.411	2.385	-1.974	1.974
3	LEU	4	PHE	1.972	0.000	1.972	1.972
179	PRO	180	TRP	2.211	0.245	1.966	1.966
574	GLU	635	SER	0.000	1.965	-1.965	1.965
184	VAL	190	TYR	0.000	1.946	-1.946	1.946
465	SER	466	THR	1.429	3.374	-1.945	1.945
51	SER	359	PRO	2.110	0.183	1.927	1.927
621	VAL	636	ILE	0.000	1.925	-1.925	1.925
560	LEU	640	ILE	0.000	1.923	-1.923	1.923
120	ASN	201	ALA	0.077	1.988	-1.911	1.911
513	ARG	514	ARG	2.251	0.362	1.889	1.889
569	SER	641	SER	4.047	5.926	-1.880	1.880
217	LEU	372	CYS	0.000	1.868	-1.868	1.868
426	PHE	427	TYR	5.087	6.942	-1.855	1.855
66	VAL	146	ARG	0.000	1.853	-1.853	1.853
593	ARG	673	SER	1.836	0.000	1.836	1.836
671	SER	689	ILE	1.011	2.837	-1.826	1.826
624	ILE	656	ARG	1.822	0.000	1.822	1.822
218	CYS	374	CYS	0.000	1.804	-1.804	1.804
168	PRO	190	TYR	3.800	5.601	-1.802	1.802
122	LYS	158	TRP	3.711	5.491	-1.780	1.780
637	ILE	652	LEU	0.386	2.162	-1.776	1.776
70	LEU	126	LEU	0.269	2.033	-1.764	1.764
113	LEU	184	VAL	0.000	1.750	-1.750	1.750
134	MET	215	ARG	0.000	1.748	-1.748	1.748
54	SER	358	THR	0.000	1.744	-1.744	1.744
53	TYR	363	LEU	1.731	0.000	1.731	1.731
363	LEU	367	TRP	0.000	1.729	-1.729	1.729
76	VAL	158	TRP	0.555	2.280	-1.725	1.725
41	CYS	89	MET	0.000	1.716	-1.716	1.716
310	ARG	370	LEU	0.000	1.709	-1.709	1.709
221	GLU	222	PRO	0.557	2.262	-1.705	1.705
552	CYS	625	CYS	0.000	1.687	-1.687	1.687
114	CYS	161	SER	4.398	2.714	1.684	1.684
225	LEU	226	HIS	1.681	0.000	1.681	1.681
558	VAL	568	LEU	1.680	0.000	1.680	1.680
699	ASN	702	ARG	0.685	2.363	-1.678	1.678
74	TRP	122	LYS	1.523	3.196	-1.673	1.673
623	GLU	625	CYS	0.000	1.672	-1.672	1.672
213	THR	313	LEU	0.000	1.670	-1.670	1.670
558	VAL	569	SER	1.665	0.000	1.665	1.665
110	LEU	165	SER	2.130	3.794	-1.664	1.664
172	TRP	190	TYR	3.489	5.151	-1.662	1.662
556	GLY	571	SER	1.659	0.000	1.659	1.659
397	PHE	399	PHE	1.655	0.000	1.655	1.655
308	GLN	364	SER	0.000	1.653	-1.653	1.653
556	GLY	570	LEU	1.653	0.000	1.653	1.653
47	ALA	356	THR	3.129	1.477	1.652	1.652
129	TYR	133	THR	2.199	3.841	-1.643	1.643
348	PHE	352	LEU	0.000	1.628	-1.628	1.628
212	LEU	216	LEU	0.732	2.358	-1.626	1.626
473	CYS	474	THR	2.825	4.437	-1.612	1.612
204	LEU	208	LEU	0.000	1.611	-1.611	1.611
141	GLN	373	GLY	1.609	0.000	1.609	1.609
557	THR	617	ILE	0.000	1.606	-1.606	1.606
91	LEU	105	CYS	3.020	1.421	1.599	1.599
570	LEU	639	ASN	0.095	1.694	-1.599	1.599
117	LEU	197	VAL	1.599	0.000	1.599	1.599
120	ASN	320	VAL	0.000	1.597	-1.597	1.597
699	ASN	710	TYR	0.000	1.593	-1.593	1.593
88	PHE	180	TRP	0.000	1.592	-1.592	1.592
77	ASP	119	SER	2.361	0.776	1.585	1.585
217	LEU	309	LYS	1.576	0.000	1.576	1.576
205	LEU	320	VAL	0.000	1.573	-1.573	1.573
286	GLU	287	ALA	1.784	0.216	1.568	1.568
37	PHE	92	GLN	0.000	1.557	-1.557	1.557
427	TYR	428	HIS	4.465	2.908	1.557	1.557
114	CYS	162	LEU	3.170	1.617	1.553	1.553
180	TRP	575	VAL	1.550	0.000	1.550	1.550
27	ASN	31	THR	0.000	1.550	-1.550	1.550
216	LEU	309	LYS	0.858	2.402	-1.545	1.545
435	CYS	436	GLU	0.008	1.553	-1.544	1.544
270	SER	271	SER	1.538	0.000	1.538	1.538
673	SER	686	ASN	1.177	2.711	-1.534	1.534
439	LYS	440	ASP	1.529	0.000	1.529	1.529
560	LEU	616	LYS	1.527	0.000	1.527	1.527
167	LEU	190	TYR	0.000	1.526	-1.526	1.526
561	HIS	567	THR	1.525	0.000	1.525	1.525
48	LEU	79	LEU	2.124	0.601	1.523	1.523
53	TYR	362	VAL	0.000	1.522	-1.522	1.522
178	THR	344	GLU	0.000	1.521	-1.521	1.521
71	VAL	74	TRP	0.000	1.516	-1.516	1.516
55	LEU	59	LEU	0.000	1.513	-1.513	1.513
85	VAL	112	TYR	1.511	0.000	1.511	1.511
676	LEU	685	ILE	5.720	7.230	-1.509	1.509
212	LEU	313	LEU	0.000	1.498	-1.498	1.498
97	VAL	101	PHE	1.549	0.052	1.497	1.497
651	SER	666	LEU	0.000	1.490	-1.490	1.490
55	LEU	72	ALA	2.171	0.684	1.486	1.486
136	ARG	140	SER	1.484	0.000	1.484	1.484
554	PHE	572	THR	1.481	0.000	1.481	1.481
93	TRP	101	PHE	0.000	1.478	-1.478	1.478
551	LEU	623	GLU	0.000	1.476	-1.476	1.476
195	SER	331	VAL	0.427	1.898	-1.471	1.471
163	LEU	167	LEU	1.469	0.000	1.469	1.469
229	TYR	665	ASP	0.000	1.464	-1.464	1.464
220	GLU	302	PHE	1.461	0.000	1.461	1.461
54	SER	359	PRO	0.262	1.717	-1.456	1.456
39	LEU	349	LEU	0.000	1.456	-1.456	1.456
332	VAL	338	PHE	0.000	1.453	-1.453	1.453
214	HIS	218	CYS	1.835	0.383	1.452	1.452
401	LEU	403	PHE	1.449	0.000	1.449	1.449
36	LEU	345	THR	0.000	1.443	-1.443	1.443
180	TRP	344	GLU	0.000	1.440	-1.440	1.440
217	LEU	374	CYS	0.000	1.439	-1.439	1.439
549	ILE	625	CYS	0.000	1.432	-1.432	1.432
575	VAL	633	THR	0.000	1.432	-1.432	1.432
191	VAL	330	MET	0.854	2.286	-1.432	1.432
670	ALA	672	TYR	1.429	0.000	1.429	1.429
310	ARG	371	PRO	0.000	1.428	-1.428	1.428
569	SER	640	ILE	0.000	1.427	-1.427	1.427
424	SER	425	ILE	1.710	3.134	-1.424	1.424
322	LEU	353	LEU	0.804	2.220	-1.416	1.416
530	TRP	531	CYS	0.000	1.404	-1.404	1.404
33	ASN	180	TRP	0.000	1.401	-1.401	1.401
367	TRP	370	LEU	0.649	2.047	-1.398	1.398
37	PHE	41	CYS	0.000	1.396	-1.396	1.396
519	GLU	520	SER	1.395	0.000	1.395	1.395
323	TRP	354	ALA	0.079	1.469	-1.391	1.391
74	TRP	123	ALA	3.651	2.268	1.383	1.383
44	THR	86	THR	1.373	0.000	1.373	1.373
74	TRP	315	LEU	0.518	1.889	-1.371	1.371
573	TYR	635	SER	0.402	1.764	-1.362	1.362
71	VAL	362	VAL	1.362	0.000	1.362	1.362
15	LEU	16	TRP	1.355	0.000	1.355	1.355
44	THR	82	VAL	2.325	0.972	1.352	1.352
5	LEU	6	SER	0.147	1.490	-1.342	1.342
89	MET	348	PHE	1.339	0.000	1.339	1.339
176	VAL	185	ASP	0.414	1.752	-1.338	1.338
44	THR	85	VAL	0.000	1.337	-1.337	1.337
36	LEU	180	TRP	0.000	1.335	-1.335	1.335
639	ASN	649	SER	2.568	1.235	1.333	1.333
654	TYR	656	ARG	1.444	0.112	1.332	1.332
102	GLN	177	ARG	0.000	1.330	-1.330	1.330
4	PHE	5	LEU	0.000	1.321	-1.321	1.321
118	SER	157	VAL	1.067	2.383	-1.316	1.316
312	ALA	361	PHE	0.000	1.314	-1.314	1.314
425	ILE	426	PHE	1.504	2.816	-1.312	1.312
253	PRO	254	GLU	1.382	2.687	-1.305	1.305
561	HIS	566	LYS	1.299	0.000	1.299	1.299
642	GLN	647	VAL	0.000	1.298	-1.298	1.298
137	GLY	224	ARG	0.000	1.283	-1.283	1.283
564	THR	566	LYS	1.853	3.131	-1.279	1.279
48	LEU	52	ILE	0.075	1.352	-1.277	1.277
311	PHE	360	VAL	0.000	1.276	-1.276	1.276
86	THR	90	PHE	0.019	1.290	-1.271	1.271
638	SER	651	SER	0.387	1.653	-1.266	1.266
93	TRP	94	PRO	3.492	2.226	1.265	1.265
672	TYR	687	ILE	0.461	1.725	-1.264	1.264
194	LEU	327	MET	0.000	1.264	-1.264	1.264
131	PHE	212	LEU	2.437	1.178	1.259	1.259
67	VAL	308	GLN	0.000	1.258	-1.258	1.258
570	LEU	638	SER	0.000	1.256	-1.256	1.256
164	LEU	194	LEU	0.417	1.671	-1.254	1.254
67	VAL	361	PHE	0.000	1.253	-1.253	1.253
654	TYR	660	ARG	4.147	5.396	-1.249	1.249
385	VAL	387	SER	1.248	0.000	1.248	1.248
480	GLU	481	ALA	0.000	1.238	-1.238	1.238
68	SER	361	PHE	0.000	1.223	-1.223	1.223
51	SER	75	SER	1.615	2.838	-1.222	1.222
4	PHE	6	SER	1.220	0.000	1.220	1.220
92	GLN	179	PRO	0.000	1.218	-1.218	1.218
178	THR	183	LEU	0.000	1.215	-1.215	1.215
577	ALA	653	ARG	0.000	1.215	-1.215	1.215
58	LEU	361	PHE	0.000	1.215	-1.215	1.215
565	GLY	599	HIS	0.000	1.211	-1.211	1.211
324	LEU	328	MET	0.104	1.306	-1.202	1.202
129	TYR	130	ASN	0.206	1.397	-1.191	1.191
554	PHE	654	TYR	0.000	1.184	-1.184	1.184
466	THR	467	GLN	2.527	1.348	1.179	1.179
556	GLY	618	HIS	0.000	1.170	-1.170	1.170
340	SER	343	LEU	1.119	2.281	-1.162	1.162
84	SER	115	GLN	1.160	0.000	1.160	1.160
537	ARG	538	THR	1.157	0.000	1.157	1.157
319	LYS	355	THR	0.000	1.153	-1.153	1.153
559	SER	615	VAL	0.000	1.150	-1.150	1.150
183	LEU	326	MET	0.000	1.149	-1.149	1.149
674	LEU	676	LEU	0.485	1.634	-1.148	1.148
169	LEU	175	PHE	0.000	1.147	-1.147	1.147
483	GLN	484	ASP	5.406	6.551	-1.145	1.145
165	SER	175	PHE	0.000	1.141	-1.141	1.141
217	LEU	220	GLU	1.136	0.000	1.136	1.136
83	LEU	111	MET	0.038	1.174	-1.136	1.136
560	LEU	566	LYS	1.133	0.000	1.133	1.133
184	VAL	186	CYS	1.132	0.000	1.132	1.132
53	TYR	57	SER	2.933	4.062	-1.130	1.130
464	SER	465	SER	0.768	1.893	-1.126	1.126
700	SER	703	GLN	1.222	0.106	1.116	1.116
74	TRP	126	LEU	0.975	2.082	-1.107	1.107
578	GLU	580	GLN	0.000	1.102	-1.102	1.102
571	SER	573	TYR	3.472	4.574	-1.101	1.101
555	GLN	619	LEU	0.000	1.099	-1.099	1.099
22	SER	23	THR	2.028	0.929	1.099	1.099
671	SER	691	ASP	2.808	1.711	1.097	1.097
677	PRO	724	ARG	1.102	0.007	1.096	1.096
575	VAL	637	ILE	0.000	1.094	-1.094	1.094
213	THR	217	LEU	0.000	1.088	-1.088	1.088
560	LEU	617	ILE	0.000	1.083	-1.083	1.083
670	ALA	691	ASP	7.091	6.009	1.082	1.082
12	ASP	13	SER	1.073	0.000	1.073	1.073
636	ILE	653	ARG	1.265	2.334	-1.069	1.069
71	VAL	358	THR	0.000	1.064	-1.064	1.064
549	ILE	626	ASP	0.000	1.063	-1.063	1.063
209	SER	317	LEU	0.000	1.061	-1.061	1.061
80	MET	114	CYS	0.000	1.051	-1.051	1.051
57	SER	362	VAL	0.000	1.048	-1.048	1.048
101	PHE	104	LEU	1.046	0.000	1.046	1.046
168	PRO	174	ALA	0.000	1.034	-1.034	1.034
672	TYR	689	ILE	6.037	7.069	-1.033	1.033
616	LYS	618	HIS	4.957	3.926	1.031	1.031
685	ILE	716	LEU	1.082	0.053	1.029	1.029
124	THR	208	LEU	1.024	0.000	1.024	1.024
127	VAL	205	LEU	0.933	1.955	-1.022	1.022
552	CYS	622	LEU	0.000	1.019	-1.019	1.019
677	PRO	684	ASP	0.813	1.829	-1.016	1.016
630	ALA	633	THR	0.000	1.015	-1.015	1.015
304	VAL	308	GLN	0.000	1.013	-1.013	1.013
214	HIS	219	SER	0.000	1.010	-1.010	1.010
154	VAL	158	TRP	0.419	1.428	-1.009	1.009
202	PHE	206	VAL	1.320	2.326	-1.006	1.006
603	SER	604	GLU	0.999	0.000	0.999	0.999
490	ASP	491	ALA	0.325	1.324	-0.999	0.999
112	TYR	183	LEU	0.000	0.998	-0.998	0.998
606	SER	607	SER	0.997	0.000	0.997	0.997
326	MET	351	THR	0.000	0.992	-0.992	0.992
322	LEU	351	THR	0.000	0.990	-0.990	0.990
640	ILE	652	LEU	0.000	0.987	-0.987	0.987
416	ASP	417	TYR	0.000	0.984	-0.984	0.984
184	VAL	191	VAL	0.000	0.983	-0.983	0.983
186	CYS	330	MET	0.000	0.978	-0.978	0.978
514	ARG	515	LEU	2.895	1.917	0.978	0.978
110	LEU	169	LEU	1.833	0.856	0.977	0.977
117	LEU	121	LEU	0.976	0.000	0.976	0.976
222	PRO	302	PHE	0.000	0.976	-0.976	0.976
454	VAL	456	ILE	0.967	0.000	0.967	0.967
117	LEU	164	LEU	1.213	2.176	-0.962	0.962
105	CYS	177	ARG	0.000	0.959	-0.959	0.959
448	ILE	449	PHE	0.000	0.953	-0.953	0.953
554	PHE	622	LEU	0.950	0.000	0.950	0.950
178	THR	179	PRO	0.456	1.404	-0.948	0.948
188	SER	334	ASN	1.476	2.423	-0.947	0.947
131	PHE	135	HIS	5.123	6.064	-0.942	0.942
591	VAL	616	LYS	0.938	0.000	0.938	0.938
555	GLN	572	THR	0.935	0.000	0.935	0.935
188	SER	192	LEU	0.933	0.000	0.933	0.933
569	SER	639	ASN	0.766	1.698	-0.932	0.932
92	GLN	180	TRP	0.000	0.930	-0.930	0.930
560	LEU	614	SER	0.000	0.928	-0.928	0.928
453	LYS	455	GLU	7.712	6.787	0.924	0.924
588	LYS	590	GLU	3.701	4.625	-0.924	0.924
117	LEU	194	LEU	0.000	0.921	-0.921	0.921
554	PHE	620	GLU	0.000	0.917	-0.917	0.917
311	PHE	363	LEU	0.000	0.916	-0.916	0.916
420	ASP	421	ASP	1.536	0.620	0.916	0.916
577	ALA	632	ASP	0.000	0.915	-0.915	0.915
67	VAL	130	ASN	0.000	0.913	-0.913	0.913
320	VAL	324	LEU	0.911	0.000	0.911	0.911
113	LEU	165	SER	0.423	1.325	-0.901	0.901
82	VAL	355	THR	0.896	0.000	0.896	0.896
51	SER	79	LEU	2.021	2.908	-0.887	0.887
31	THR	35	TYR	0.883	0.000	0.883	0.883
311	PHE	370	LEU	0.882	0.000	0.882	0.882
57	SER	363	LEU	0.881	0.000	0.881	0.881
558	VAL	616	LYS	0.000	0.880	-0.880	0.880
617	ILE	619	LEU	0.000	0.880	-0.880	0.880
563	PRO	612	ASP	0.000	0.880	-0.880	0.880
291	GLU	293	ARG	0.000	0.879	-0.879	0.879
377	ASN	379	ARG	0.876	0.000	0.876	0.876
65	THR	372	CYS	0.876	0.000	0.876	0.876
608	SER	609	THR	0.866	0.000	0.866	0.866
566	LYS	643	SER	6.218	5.355	0.863	0.863
307	ALA	364	SER	0.000	0.861	-0.861	0.861
554	PHE	623	GLU	0.000	0.861	-0.861	0.861
364	SER	366	ARG	0.853	0.000	0.853	0.853
329	HIS	340	SER	0.089	0.939	-0.850	0.850
571	SER	637	ILE	0.822	1.666	-0.844	0.844
640	ILE	649	SER	3.337	2.501	0.836	0.836
556	GLY	572	THR	0.835	0.000	0.835	0.835
23	THR	25	LEU	0.829	0.000	0.829	0.829
73	SER	158	TRP	1.338	0.509	0.829	0.829
84	SER	112	TYR	2.404	3.232	-0.828	0.828
326	MET	330	MET	1.670	0.843	0.827	0.827
487	ASN	488	LYS	2.541	3.367	-0.826	0.826
113	LEU	190	TYR	0.347	1.173	-0.826	0.826
549	ILE	624	ILE	0.000	0.825	-0.825	0.825
558	VAL	652	LEU	0.000	0.815	-0.815	0.815
127	VAL	313	LEU	0.000	0.812	-0.812	0.812
326	MET	348	PHE	0.000	0.804	-0.804	0.804
113	LEU	175	PHE	0.000	0.802	-0.802	0.802
75	SER	358	THR	0.000	0.801	-0.801	0.801
67	VAL	312	ALA	0.000	0.796	-0.796	0.796
67	VAL	129	TYR	1.405	0.611	0.794	0.794
47	ALA	82	VAL	0.815	1.609	-0.794	0.794
508	SER	509	GLU	1.403	0.609	0.794	0.794
106	THR	169	LEU	0.000	0.793	-0.793	0.793
570	LEU	594	SER	0.000	0.793	-0.793	0.793
503	GLU	504	GLU	0.827	1.615	-0.788	0.788
88	PHE	109	ALA	0.000	0.786	-0.786	0.786
304	VAL	368	THR	0.000	0.785	-0.785	0.785
188	SER	190	TYR	0.000	0.783	-0.783	0.783
590	GLU	616	LYS	0.776	0.000	0.776	0.776
562	ALA	564	THR	0.771	0.000	0.771	0.771
302	PHE	306	VAL	0.985	1.755	-0.770	0.770
67	VAL	126	LEU	0.376	1.145	-0.769	0.769
13	SER	14	SER	0.768	0.000	0.768	0.768
553	ALA	622	LEU	0.000	0.765	-0.765	0.765
568	LEU	641	SER	1.091	0.326	0.765	0.765
702	ARG	710	TYR	0.000	0.765	-0.765	0.765
118	SER	158	TRP	0.468	1.232	-0.764	0.764
547	LEU	549	ILE	0.000	0.756	-0.756	0.756
515	LEU	516	SER	0.537	1.286	-0.748	0.748
26	LEU	27	ASN	0.000	0.748	-0.748	0.748
140	SER	143	ALA	0.747	0.000	0.747	0.747
51	SER	78	ASP	1.431	0.684	0.747	0.747
52	ILE	79	LEU	1.189	0.449	0.740	0.740
488	LYS	489	LYS	1.929	1.190	0.739	0.739
109	ALA	183	LEU	0.000	0.738	-0.738	0.738
572	THR	636	ILE	0.000	0.732	-0.732	0.732
102	GLN	105	CYS	0.106	0.836	-0.730	0.730
209	SER	313	LEU	0.000	0.729	-0.729	0.729
566	LYS	644	SER	0.000	0.726	-0.726	0.726
260	SER	261	LEU	0.724	0.000	0.724	0.724
14	SER	15	LEU	0.000	0.724	-0.724	0.724
145	ARG	150	VAL	0.723	0.000	0.723	0.723
653	ARG	661	PHE	3.221	2.499	0.722	0.722
479	THR	480	GLU	0.000	0.721	-0.721	0.721
599	HIS	613	THR	0.000	0.721	-0.721	0.721
568	LEU	615	VAL	0.550	1.270	-0.719	0.719
679	SER	727	GLU	3.915	4.632	-0.718	0.718
187	SER	334	ASN	0.000	0.716	-0.716	0.716
123	ALA	320	VAL	0.000	0.716	-0.716	0.716
187	SER	189	SER	0.714	0.000	0.714	0.714
205	LEU	319	LYS	0.709	0.000	0.709	0.709
687	ILE	713	GLU	6.566	5.857	0.708	0.708
459	THR	460	PRO	0.352	1.060	-0.708	0.708
198	TYR	323	TRP	3.687	4.395	-0.708	0.708
419	ASP	420	ASP	1.874	1.166	0.708	0.708
133	THR	146	ARG	0.000	0.704	-0.704	0.704
65	THR	68	SER	1.436	2.140	-0.704	0.704
185	ASP	191	VAL	0.000	0.700	-0.700	0.700
676	LEU	684	ASP	0.946	1.643	-0.697	0.697
353	LEU	356	THR	0.028	0.725	-0.696	0.696
568	LEU	640	ILE	0.000	0.693	-0.693	0.693
244	THR	264	SER	0.690	0.000	0.690	0.690
602	ASN	603	SER	0.689	0.000	0.689	0.689
40	THR	85	VAL	0.000	0.689	-0.689	0.689
69	MET	147	SER	0.778	0.090	0.689	0.689
58	LEU	64	ARG	0.000	0.688	-0.688	0.688
493	SER	494	ASP	2.948	3.633	-0.685	0.685
374	CYS	378	CYS	0.423	1.108	-0.685	0.685
639	ASN	691	ASP	0.000	0.682	-0.682	0.682
346	PHE	350	LEU	2.422	3.101	-0.680	0.680
164	LEU	167	LEU	0.000	0.678	-0.678	0.678
131	PHE	215	ARG	0.676	0.000	0.676	0.676
109	ALA	184	VAL	0.675	0.000	0.675	0.675
315	LEU	358	THR	0.000	0.671	-0.671	0.671
666	LEU	670	ALA	0.304	0.973	-0.669	0.669
205	LEU	316	ALA	0.000	0.669	-0.669	0.669
313	LEU	317	LEU	1.741	1.073	0.667	0.667
678	THR	684	ASP	0.168	0.835	-0.667	0.667
348	PHE	351	THR	0.000	0.665	-0.665	0.665
117	LEU	165	SER	0.000	0.665	-0.665	0.665
461	SER	462	LEU	0.000	0.659	-0.659	0.659
61	MET	308	GLN	0.000	0.659	-0.659	0.659
112	TYR	348	PHE	1.663	2.316	-0.653	0.653
165	SER	190	TYR	3.079	2.426	0.653	0.653
224	ARG	227	SER	0.000	0.653	-0.653	0.653
43	MET	353	LEU	1.891	2.542	-0.652	0.652
570	LEU	572	THR	0.092	0.740	-0.648	0.648
168	PRO	193	PHE	0.646	0.000	0.646	0.646
672	TYR	688	SER	1.048	1.691	-0.643	0.643
169	LEU	186	CYS	0.642	0.000	0.642	0.642
564	THR	613	THR	0.000	0.638	-0.638	0.638
599	HIS	615	VAL	0.000	0.638	-0.638	0.638
434	GLU	435	CYS	0.000	0.636	-0.636	0.636
326	MET	347	SER	3.031	3.666	-0.635	0.635
88	PHE	112	TYR	0.000	0.634	-0.634	0.634
127	VAL	212	LEU	0.420	1.051	-0.631	0.631
409	ILE	530	TRP	0.000	0.623	-0.623	0.623
64	ARG	69	MET	1.020	1.639	-0.619	0.619
659	ASN	714	ILE	0.614	0.000	0.614	0.614
261	LEU	262	ARG	0.611	0.000	0.611	0.611
113	LEU	194	LEU	0.974	0.365	0.609	0.609
574	GLU	634	VAL	0.607	0.000	0.607	0.607
369	HIS	378	CYS	0.605	0.000	0.605	0.605
634	VAL	636	ILE	0.187	0.792	-0.605	0.605
93	TRP	95	ASN	3.162	3.766	-0.604	0.604
190	TYR	194	LEU	7.295	6.693	0.602	0.602
706	GLU	710	TYR	1.351	1.952	-0.601	0.601
554	PHE	619	LEU	0.000	0.601	-0.601	0.601
307	ALA	368	THR	0.000	0.600	-0.600	0.600
110	LEU	166	ALA	1.295	0.695	0.600	0.600
63	ASN	371	PRO	0.599	0.000	0.599	0.599
81	SER	115	GLN	6.547	7.145	-0.598	0.598
183	LEU	185	ASP	0.597	0.000	0.597	0.597
395	LYS	397	PHE	0.000	0.595	-0.595	0.595
279	ALA	280	PRO	1.361	1.949	-0.588	0.588
710	TYR	712	GLU	0.131	0.715	-0.585	0.585
103	PHE	107	THR	2.228	2.810	-0.582	0.582
134	MET	212	LEU	0.248	0.829	-0.582	0.582
58	LEU	61	MET	0.000	0.580	-0.580	0.580
651	SER	663	SER	1.505	2.084	-0.580	0.580
655	SER	660	ARG	5.179	4.602	0.577	0.577
674	LEU	687	ILE	7.934	7.359	0.574	0.574
635	SER	654	TYR	0.000	0.573	-0.573	0.573
658	GLU	660	ARG	8.050	7.480	0.570	0.570
110	LEU	162	LEU	0.000	0.570	-0.570	0.570
140	SER	142	THR	0.000	0.564	-0.564	0.564
362	VAL	367	TRP	0.563	0.000	0.563	0.563
559	SER	616	LYS	0.000	0.558	-0.558	0.558
85	VAL	352	LEU	1.551	1.001	0.550	0.550
91	LEU	104	LEU	1.404	0.856	0.549	0.549
70	LEU	125	LEU	0.439	0.986	-0.548	0.548
367	TRP	369	HIS	0.000	0.544	-0.544	0.544
125	LEU	157	VAL	0.837	0.294	0.543	0.543
102	GLN	106	THR	0.000	0.540	-0.540	0.540
655	SER	658	GLU	2.715	2.175	0.540	0.540
627	ASN	629	GLU	0.554	1.092	-0.538	0.538
74	TRP	358	THR	0.000	0.536	-0.536	0.536
216	LEU	313	LEU	0.000	0.536	-0.536	0.536
551	LEU	625	CYS	0.535	0.000	0.535	0.535
570	LEU	617	ILE	0.535	0.000	0.535	0.535
127	VAL	316	ALA	0.000	0.534	-0.534	0.534
120	ASN	124	THR	0.000	0.534	-0.534	0.534
189	SER	334	ASN	0.000	0.533	-0.533	0.533
558	VAL	619	LEU	0.000	0.531	-0.531	0.531
576	SER	582	ILE	0.000	0.531	-0.531	0.531
711	GLN	715	GLN	2.227	1.699	0.528	0.528
376	ILE	377	ASN	0.528	0.000	0.528	0.528
669	THR	692	THR	0.527	0.000	0.527	0.527
50	GLY	363	LEU	0.526	0.000	0.526	0.526
202	PHE	319	LYS	0.524	0.000	0.524	0.524
576	SER	633	THR	0.000	0.523	-0.523	0.523
220	GLU	381	ASN	0.000	0.522	-0.522	0.522
671	SER	688	SER	0.000	0.520	-0.520	0.520
44	THR	352	LEU	1.197	0.679	0.518	0.518
112	TYR	351	THR	4.584	4.073	0.512	0.512
634	VAL	654	TYR	0.839	0.333	0.507	0.507
61	MET	371	PRO	0.504	0.000	0.504	0.504
84	SER	108	SER	3.550	4.053	-0.502	0.502
85	VAL	88	PHE	0.000	0.500	-0.500	0.500
61	MET	368	THR	0.500	0.000	0.500	0.500
45	PHE	49	VAL	2.364	1.864	0.500	0.500
423	ASN	424	SER	2.844	2.348	0.496	0.496
366	ARG	367	TRP	0.218	0.713	-0.495	0.495
193	PHE	197	VAL	1.861	1.367	0.494	0.494
358	THR	359	PRO	1.217	0.726	0.491	0.491
132	TYR	140	SER	0.487	0.000	0.487	0.487
343	LEU	347	SER	0.000	0.484	-0.484	0.484
58	LEU	72	ALA	1.740	2.224	-0.484	0.484
199	ALA	327	MET	0.479	0.000	0.479	0.479
107	THR	111	MET	0.000	0.479	-0.479	0.479
217	LEU	218	CYS	0.000	0.477	-0.477	0.477
619	LEU	638	SER	0.000	0.474	-0.474	0.474
238	ILE	239	PRO	0.956	0.482	0.474	0.474
202	PHE	324	LEU	0.492	0.019	0.472	0.472
562	ALA	563	PRO	0.696	0.225	0.471	0.471
549	ILE	550	PRO	0.750	1.220	-0.470	0.470
130	ASN	312	ALA	0.000	0.470	-0.470	0.470
325	PRO	350	LEU	1.265	0.796	0.470	0.470
117	LEU	201	ALA	0.466	0.000	0.466	0.466
247	ARG	249	VAL	0.464	0.000	0.464	0.464
220	GLU	306	VAL	0.462	0.000	0.462	0.462
653	ARG	662	VAL	7.561	8.017	-0.456	0.456
209	SER	316	ALA	0.454	0.000	0.454	0.454
191	VAL	331	VAL	0.000	0.451	-0.451	0.451
212	LEU	312	ALA	0.446	0.000	0.446	0.446
638	SER	650	PRO	0.739	0.292	0.446	0.446
178	THR	180	TRP	0.000	0.445	-0.445	0.445
74	TRP	312	ALA	0.000	0.445	-0.445	0.445
129	TYR	141	GLN	0.000	0.443	-0.443	0.443
205	LEU	317	LEU	0.000	0.443	-0.443	0.443
91	LEU	97	VAL	0.443	0.000	0.443	0.443
538	THR	539	PRO	0.454	0.896	-0.442	0.442
332	VAL	337	GLY	0.274	0.701	-0.427	0.427
674	LEU	686	ASN	2.328	2.755	-0.427	0.427
9	SER	10	THR	1.890	2.314	-0.424	0.424
102	GLN	182	CYS	0.422	0.000	0.422	0.422
511	PRO	512	GLU	0.420	0.000	0.420	0.420
323	TRP	326	MET	0.418	0.000	0.418	0.418
654	TYR	661	PHE	3.831	4.247	-0.416	0.416
495	LYS	496	THR	2.907	3.323	-0.415	0.415
552	CYS	621	VAL	0.000	0.411	-0.411	0.411
551	LEU	624	ILE	0.000	0.408	-0.408	0.408
192	LEU	335	VAL	0.000	0.408	-0.408	0.408
552	CYS	554	PHE	0.000	0.405	-0.405	0.405
89	MET	92	GLN	0.000	0.405	-0.405	0.405
285	ALA	286	GLU	1.160	0.757	0.402	0.402
120	ASN	202	PHE	0.000	0.402	-0.402	0.402
272	ASP	273	THR	0.000	0.402	-0.402	0.402
83	LEU	87	ILE	1.116	0.716	0.399	0.399
623	GLU	634	VAL	0.000	0.398	-0.398	0.398
132	TYR	133	THR	0.000	0.396	-0.396	0.396
69	MET	150	VAL	0.949	0.554	0.395	0.395
91	LEU	182	CYS	0.000	0.393	-0.393	0.393
80	MET	83	LEU	0.393	0.000	0.393	0.393
91	LEU	108	SER	0.000	0.391	-0.391	0.391
213	THR	218	CYS	0.000	0.390	-0.390	0.390
172	TRP	188	SER	0.000	0.390	-0.390	0.390
645	THR	646	GLN	0.000	0.389	-0.389	0.389
183	LEU	339	GLN	0.388	0.000	0.388	0.388
174	ALA	183	LEU	0.000	0.388	-0.388	0.388
452	ILE	454	VAL	0.383	0.000	0.383	0.383
331	VAL	335	VAL	0.041	0.421	-0.380	0.380
454	VAL	455	GLU	0.000	0.378	-0.378	0.378
552	CYS	574	GLU	0.377	0.000	0.377	0.377
311	PHE	361	PHE	1.116	0.740	0.376	0.376
369	HIS	372	CYS	0.375	0.000	0.375	0.375
355	THR	356	THR	0.000	0.374	-0.374	0.374
55	LEU	79	LEU	0.833	0.460	0.372	0.372
537	ARG	593	ARG	0.000	0.366	-0.366	0.366
54	SER	58	LEU	0.651	1.014	-0.363	0.363
322	LEU	354	ALA	2.504	2.867	-0.363	0.363
567	THR	641	SER	0.918	0.557	0.361	0.361
322	LEU	357	VAL	0.000	0.361	-0.361	0.361
523	PRO	524	ASP	0.360	0.000	0.360	0.360
524	ASP	525	LEU	0.358	0.000	0.358	0.358
128	SER	208	LEU	1.192	1.547	-0.355	0.355
112	TYR	115	GLN	0.153	0.506	-0.353	0.353
28	PRO	31	THR	1.128	1.481	-0.353	0.353
556	GLY	661	PHE	0.000	0.350	-0.350	0.350
681	PRO	682	ASP	0.750	0.400	0.350	0.350
217	LEU	310	ARG	0.000	0.349	-0.349	0.349
256	ALA	257	PRO	0.860	0.511	0.349	0.349
220	GLU	380	GLN	0.000	0.348	-0.348	0.348
690	PRO	696	HIS	1.503	1.158	0.345	0.345
549	ILE	587	LYS	0.000	0.344	-0.344	0.344
40	THR	352	LEU	0.177	0.519	-0.343	0.343
219	SER	302	PHE	0.342	0.000	0.342	0.342
633	THR	634	VAL	0.000	0.341	-0.341	0.341
162	LEU	165	SER	0.000	0.339	-0.339	0.339
112	TYR	198	TYR	0.339	0.000	0.339	0.339
35	TYR	39	LEU	0.000	0.337	-0.337	0.337
67	VAL	71	VAL	0.337	0.000	0.337	0.337
664	CYS	665	ASP	0.335	0.000	0.335	0.335
46	ALA	356	THR	0.802	0.469	0.333	0.333
717	LEU	721	TYR	2.737	3.070	-0.332	0.332
252	SER	253	PRO	0.462	0.793	-0.331	0.331
55	LEU	76	VAL	0.739	0.410	0.330	0.330
356	THR	357	VAL	0.373	0.044	0.329	0.329
558	VAL	615	VAL	0.000	0.327	-0.327	0.327
58	LEU	68	SER	1.602	1.929	-0.327	0.327
58	LEU	71	VAL	1.341	1.662	-0.321	0.321
505	THR	506	THR	3.268	2.957	0.312	0.312
607	SER	608	SER	0.350	0.038	0.311	0.311
249	VAL	251	LEU	0.308	0.000	0.308	0.308
687	ILE	689	ILE	0.000	0.307	-0.307	0.307
652	LEU	662	VAL	1.100	1.407	-0.306	0.306
40	THR	348	PHE	0.000	0.305	-0.305	0.305
723	LYS	727	GLU	3.792	4.096	-0.303	0.303
106	THR	175	PHE	2.009	2.312	-0.303	0.303
589	ILE	618	HIS	0.300	0.000	0.300	0.300
191	VAL	195	SER	0.000	0.299	-0.299	0.299
451	ALA	452	ILE	0.000	0.297	-0.297	0.297
175	PHE	184	VAL	0.000	0.295	-0.295	0.295
164	LEU	193	PHE	1.877	1.583	0.294	0.294
368	THR	369	HIS	0.351	0.058	0.293	0.293
666	LEU	691	ASP	0.793	1.086	-0.293	0.293
712	GLU	715	GLN	6.654	6.364	0.291	0.291
363	LEU	368	THR	0.288	0.000	0.288	0.288
302	PHE	305	SER	0.107	0.395	-0.288	0.288
65	THR	373	GLY	0.287	0.000	0.287	0.287
329	HIS	347	SER	0.000	0.287	-0.287	0.287
350	LEU	353	LEU	0.032	0.319	-0.287	0.287
118	SER	122	LYS	2.585	2.872	-0.287	0.287
522	LYS	523	PRO	0.124	0.409	-0.285	0.285
554	PHE	659	ASN	0.000	0.284	-0.284	0.284
74	TRP	77	ASP	1.067	1.348	-0.281	0.281
318	THR	357	VAL	0.495	0.775	-0.281	0.281
357	VAL	360	VAL	0.000	0.279	-0.279	0.279
334	ASN	335	VAL	0.000	0.278	-0.278	0.278
648	ARG	665	ASP	0.277	0.000	0.277	0.277
2	SER	3	LEU	0.000	0.275	-0.275	0.275
308	GLN	367	TRP	0.273	0.000	0.273	0.273
341	LEU	344	GLU	0.000	0.272	-0.272	0.272
712	GLU	714	ILE	1.046	0.778	0.267	0.267
360	VAL	363	LEU	0.000	0.267	-0.267	0.267
81	SER	355	THR	1.217	1.484	-0.267	0.267
121	LEU	201	ALA	0.356	0.091	0.265	0.265
183	LEU	344	GLU	0.313	0.576	-0.263	0.263
686	ASN	713	GLU	0.305	0.044	0.261	0.261
123	ALA	205	LEU	2.559	2.299	0.261	0.261
345	THR	349	LEU	0.000	0.259	-0.259	0.259
481	ALA	482	LYS	0.000	0.258	-0.258	0.258
172	TRP	193	PHE	0.000	0.256	-0.256	0.256
573	TYR	689	ILE	0.000	0.256	-0.256	0.256
441	PRO	442	GLN	0.399	0.651	-0.252	0.252
166	ALA	169	LEU	0.000	0.252	-0.252	0.252
352	LEU	355	THR	0.250	0.000	0.250	0.250
20	HIS	21	ASN	0.000	0.250	-0.250	0.250
255	ASP	256	ALA	0.249	0.000	0.249	0.249
359	PRO	363	LEU	0.249	0.000	0.249	0.249
54	SER	362	VAL	0.184	0.433	-0.249	0.249
658	GLU	662	VAL	1.176	0.927	0.248	0.248
482	LYS	483	GLN	5.130	5.377	-0.247	0.247
310	ARG	314	ILE	0.246	0.000	0.246	0.246
605	ASP	606	SER	0.245	0.000	0.245	0.245
689	ILE	690	PRO	0.604	0.848	-0.245	0.245
61	MET	68	SER	0.000	0.244	-0.244	0.244
687	ILE	717	LEU	1.077	1.318	-0.241	0.241
78	ASP	354	ALA	0.000	0.241	-0.241	0.241
43	MET	352	LEU	0.559	0.800	-0.241	0.241
689	ILE	691	ASP	0.241	0.000	0.241	0.241
651	SER	662	VAL	0.294	0.533	-0.239	0.239
362	VAL	363	LEU	0.237	0.000	0.237	0.237
82	VAL	86	THR	0.229	0.466	-0.237	0.237
40	THR	349	LEU	0.621	0.385	0.236	0.236
83	LEU	86	THR	0.235	0.000	0.235	0.235
146	ARG	149	GLN	0.000	0.233	-0.233	0.233
642	GLN	644	SER	0.062	0.293	-0.231	0.231
66	VAL	70	LEU	0.218	0.448	-0.230	0.230
392	ILE	393	LYS	0.000	0.230	-0.230	0.230
176	VAL	181	GLY	0.000	0.225	-0.225	0.225
202	PHE	205	LEU	0.000	0.225	-0.225	0.225
326	MET	344	GLU	0.000	0.223	-0.223	0.223
714	ILE	718	ASN	0.260	0.482	-0.222	0.222
167	LEU	168	PRO	0.946	0.724	0.221	0.221
518	GLU	519	GLU	0.590	0.811	-0.221	0.221
725	GLU	729	LYS	3.334	3.554	-0.220	0.220
68	SER	69	MET	0.260	0.041	0.220	0.220
562	ALA	566	LYS	0.219	0.000	0.219	0.219
666	LEU	672	TYR	0.966	1.183	-0.217	0.217
619	LEU	661	PHE	0.000	0.217	-0.217	0.217
561	HIS	613	THR	0.000	0.216	-0.216	0.216
65	THR	67	VAL	0.396	0.612	-0.216	0.216
51	SER	355	THR	0.215	0.000	0.215	0.215
195	SER	327	MET	2.177	2.392	-0.215	0.215
97	VAL	100	TYR	0.000	0.214	-0.214	0.214
153	VAL	156	THR	0.094	0.308	-0.214	0.214
375	ILE	401	LEU	0.000	0.212	-0.212	0.212
562	ALA	615	VAL	0.260	0.050	0.210	0.210
524	ASP	526	SER	0.000	0.206	-0.206	0.206
206	VAL	210	VAL	0.205	0.000	0.205	0.205
568	LEU	642	GLN	0.000	0.204	-0.204	0.204
27	ASN	28	PRO	0.556	0.353	0.203	0.203
525	LEU	528	TRP	0.000	0.203	-0.203	0.203
484	ASP	485	SER	2.281	2.484	-0.203	0.203
711	GLN	716	LEU	5.682	5.480	0.202	0.202
242	PRO	243	PRO	0.943	0.742	0.201	0.201
390	LYS	391	LYS	0.000	0.200	-0.200	0.200
621	VAL	661	PHE	0.000	0.200	-0.200	0.200
372	CYS	374	CYS	0.849	1.049	-0.199	0.199
126	LEU	315	LEU	0.199	0.000	0.199	0.199
642	GLN	693	VAL	0.000	0.199	-0.199	0.199
76	VAL	80	MET	0.198	0.000	0.198	0.198
146	ARG	150	VAL	0.000	0.195	-0.195	0.195
332	VAL	336	VAL	0.430	0.236	0.195	0.195
428	HIS	430	LEU	0.000	0.193	-0.193	0.193
210	VAL	211	PRO	1.178	1.372	-0.193	0.193
218	CYS	378	CYS	0.000	0.193	-0.193	0.193
217	LEU	373	GLY	0.000	0.191	-0.191	0.191
447	ASN	448	ILE	0.272	0.083	0.189	0.189
78	ASP	119	SER	0.188	0.000	0.188	0.188
172	TRP	186	CYS	0.188	0.000	0.188	0.188
318	THR	322	LEU	0.672	0.857	-0.185	0.185
216	LEU	306	VAL	0.000	0.185	-0.185	0.185
674	LEU	689	ILE	0.000	0.184	-0.184	0.184
63	ASN	68	SER	0.210	0.026	0.184	0.184
121	LEU	157	VAL	1.484	1.300	0.184	0.184
676	LEU	687	ILE	1.162	0.979	0.183	0.183
27	ASN	32	LEU	0.000	0.181	-0.181	0.181
320	VAL	325	PRO	0.181	0.000	0.181	0.181
222	PRO	223	PRO	0.647	0.467	0.180	0.180
116	GLY	323	TRP	2.609	2.789	-0.179	0.179
183	LEU	330	MET	0.000	0.175	-0.175	0.175
108	SER	182	CYS	0.000	0.174	-0.174	0.174
39	LEU	43	MET	0.167	0.340	-0.173	0.173
319	LYS	324	LEU	0.171	0.000	0.171	0.171
15	LEU	17	LYS	0.000	0.170	-0.170	0.170
570	LEU	619	LEU	1.726	1.557	0.169	0.169
290	ARG	291	GLU	0.169	0.000	0.169	0.169
62	GLN	63	ASN	0.000	0.169	-0.169	0.169
206	VAL	209	SER	0.229	0.060	0.169	0.169
270	SER	272	ASP	0.000	0.168	-0.168	0.168
85	VAL	89	MET	0.409	0.241	0.167	0.167
150	VAL	154	VAL	0.000	0.167	-0.167	0.167
599	HIS	601	PRO	0.000	0.167	-0.167	0.167
680	ASN	681	PRO	1.622	1.789	-0.167	0.167
222	PRO	224	ARG	0.167	0.000	0.167	0.167
336	VAL	338	PHE	0.632	0.799	-0.167	0.167
690	PRO	699	ASN	0.138	0.304	-0.166	0.166
87	ILE	111	MET	0.166	0.000	0.166	0.166
113	LEU	330	MET	0.166	0.000	0.166	0.166
651	SER	665	ASP	0.164	0.000	0.164	0.164
40	THR	44	THR	0.000	0.164	-0.164	0.164
73	SER	154	VAL	1.881	1.719	0.162	0.162
183	LEU	333	GLN	0.162	0.000	0.162	0.162
259	PRO	260	SER	0.000	0.159	-0.159	0.159
114	CYS	165	SER	3.304	3.462	-0.159	0.159
641	SER	649	SER	0.167	0.323	-0.157	0.157
306	VAL	310	ARG	0.156	0.312	-0.156	0.156
642	GLN	649	SER	0.000	0.154	-0.154	0.154
280	PRO	281	ALA	0.341	0.188	0.154	0.154
226	HIS	227	SER	0.153	0.000	0.153	0.153
592	TYR	616	LYS	0.152	0.000	0.152	0.152
50	GLY	359	PRO	2.994	3.143	-0.149	0.149
600	GLU	601	PRO	0.158	0.305	-0.147	0.147
315	LEU	360	VAL	0.000	0.145	-0.145	0.145
157	VAL	161	SER	0.244	0.389	-0.145	0.145
492	PHE	493	SER	1.383	1.527	-0.144	0.144
75	SER	78	ASP	0.223	0.078	0.144	0.144
131	PHE	211	PRO	1.246	1.389	-0.143	0.143
314	ILE	318	THR	0.547	0.406	0.142	0.142
675	PHE	685	ILE	1.831	1.689	0.142	0.142
90	PHE	101	PHE	0.000	0.141	-0.141	0.141
362	VAL	365	LYS	0.000	0.140	-0.140	0.140
61	MET	64	ARG	0.000	0.140	-0.140	0.140
52	ILE	56	ILE	0.943	0.804	0.139	0.139
209	SER	210	VAL	0.274	0.136	0.138	0.138
554	PHE	573	TYR	0.137	0.000	0.137	0.137
673	SER	687	ILE	2.431	2.294	0.137	0.137
124	THR	204	LEU	1.614	1.749	-0.135	0.135
126	LEU	130	ASN	0.707	0.572	0.135	0.135
550	PRO	623	GLU	0.000	0.134	-0.134	0.134
216	LEU	305	SER	0.134	0.000	0.134	0.134
583	THR	584	PRO	0.538	0.404	0.134	0.134
703	GLN	704	HIS	0.131	0.000	0.131	0.131
676	LEU	683	GLY	0.137	0.008	0.129	0.129
66	VAL	150	VAL	2.562	2.690	-0.128	0.128
370	LEU	371	PRO	0.852	0.724	0.128	0.128
660	ARG	662	VAL	0.568	0.696	-0.128	0.128
162	LEU	167	LEU	0.127	0.000	0.127	0.127
632	ASP	633	THR	0.127	0.000	0.127	0.127
414	HIS	415	GLU	0.127	0.000	0.127	0.127
74	TRP	78	ASP	0.016	0.143	-0.127	0.127
102	GLN	175	PHE	0.326	0.452	-0.126	0.126
384	ALA	385	VAL	0.148	0.024	0.124	0.124
304	VAL	375	ILE	0.123	0.000	0.123	0.123
699	ASN	713	GLU	0.000	0.122	-0.122	0.122
192	LEU	331	VAL	0.000	0.122	-0.122	0.122
572	THR	638	SER	0.000	0.121	-0.121	0.121
114	CYS	158	TRP	0.049	0.168	-0.120	0.120
254	GLU	255	ASP	0.845	0.964	-0.118	0.118
634	VAL	656	ARG	0.000	0.115	-0.115	0.115
47	ALA	355	THR	1.794	1.680	0.114	0.114
78	ASP	359	PRO	0.113	0.000	0.113	0.113
702	ARG	706	GLU	0.000	0.112	-0.112	0.112
126	LEU	316	ALA	0.000	0.111	-0.111	0.111
190	TYR	191	VAL	0.111	0.000	0.111	0.111
558	VAL	560	LEU	0.717	0.606	0.111	0.111
56	ILE	60	LYS	1.390	1.500	-0.111	0.111
68	SER	371	PRO	0.109	0.000	0.109	0.109
241	THR	242	PRO	1.008	1.117	-0.108	0.108
728	SER	729	LYS	0.108	0.000	0.108	0.108
652	LEU	661	PHE	0.166	0.058	0.108	0.108
163	LEU	168	PRO	0.107	0.000	0.107	0.107
77	ASP	122	LYS	6.308	6.415	-0.107	0.107
625	CYS	656	ARG	0.145	0.252	-0.107	0.107
100	TYR	101	PHE	0.000	0.103	-0.103	0.103
110	LEU	190	TYR	0.102	0.000	0.102	0.102
70	LEU	154	VAL	0.515	0.616	-0.101	0.101
507	PHE	508	SER	0.100	0.000	0.100	0.100
36	LEU	349	LEU	0.293	0.392	-0.100	0.100
172	TRP	174	ALA	0.099	0.000	0.099	0.099
165	SER	166	ALA	0.099	0.000	0.099	0.099
652	LEU	663	SER	0.521	0.618	-0.097	0.097
35	TYR	36	LEU	0.000	0.097	-0.097	0.097
685	ILE	720	ALA	0.515	0.611	-0.096	0.096
287	ALA	288	CYS	0.290	0.384	-0.094	0.094
134	MET	216	LEU	0.810	0.903	-0.093	0.093
54	SER	71	VAL	0.092	0.000	0.092	0.092
624	ILE	626	ASP	0.163	0.071	0.091	0.091

RRCS change distribution

-0.43

Mean ΔRRCS

1.91

Std Dev

-0.20

Median

Magnitude classification

High (|Δ| ≥ 5.0)

111

Medium (2.8 ≤ |Δ| < 5.0)

987

Low (|Δ| < 2.8)

Methods

RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).

Significance threshold. |ΔRRCS| ≥ 2.76, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.

Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.

Structural annotation. TM domain boundaries and generic numbering from GPCRdb.

What is RRCS?

Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.

ΔRRCS (Delta RRCS) shows the difference in contact strength between states:

Positive ΔRRCS. Contact is stronger in the active state.
Negative ΔRRCS. Contact is stronger in the inactive state.
Large |ΔRRCS|. Significant structural rearrangement.

Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.

Pathogenicity predictions

AlphaMissense predicts whether a mutation harms protein function:

Pathogenic (score ≥ 0.564): mutation likely damages function.
Ambiguous (0.34–0.563): effect uncertain.
Benign (< 0.34): mutation likely tolerated.

Conservation & population data

Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.

Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.

Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar