GP160
844
Total Contact Pairs
93
Significant Changes
15.45
Max Increase
-16.75
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | PHE255 (6.51x51) | TYR281 (7.42x41) | 0.000 | 16.752 | -16.752 | HIGH |
| 2 | LYS237 (6.33x33) | TRP293 (7.54x54) | 15.447 | 0.000 | +15.447 | HIGH |
| 3 | VAL178 | TYR183 (5.37x37) | 0.000 | 14.812 | -14.812 | HIGH |
| 4 | PHE82 (2.66x66) | PHE89 (3.19x19) | 13.609 | 0.000 | +13.609 | HIGH |
| 5 | ASN39 (1.50x50) | ILE277 (7.38x37) | 10.855 | 0.000 | +10.855 | HIGH |
| 6 | ASN300 (8.51x51) | CYS317 | 0.000 | 10.302 | -10.302 | HIGH |
| 7 | TRP252 (6.48x48) | PHE282 (7.43x42) | 10.169 | 0.000 | +10.169 | HIGH |
| 8 | PHE124 (3.54x54) | ASN295 (7.56x56) | 9.723 | 0.000 | +9.723 | HIGH |
| 9 | LEU241 (6.37x37) | TRP293 (7.54x54) | 9.687 | 0.000 | +9.687 | HIGH |
| 10 | TYR292 (7.53x53) | LEU306 (8.57x57) | 9.647 | 0.000 | +9.647 | HIGH |
| 11 | ASP66 (2.50x50) | SER285 (7.46x46) | 0.000 | 9.591 | -9.591 | HIGH |
| 12 | PHE124 (3.54x54) | LEU207 (5.61x61) | 0.000 | 9.392 | -9.392 | HIGH |
| 13 | PHE54 (2.38x38) | GLN135 (4.38x38) | 0.000 | 9.338 | -9.338 | HIGH |
| 14 | ASP81 (2.65x65) | ARG88 (3.18x18) | 9.199 | 0.000 | +9.199 | HIGH |
| 15 | HIS109 (3.39x39) | TRP279 (7.40x39) | 8.847 | 0.000 | +8.847 | HIGH |
| 16 | MET189 (5.43x43) | PHE286 (7.47x47) | 8.690 | 0.000 | +8.690 | HIGH |
| 17 | TYR292 (7.53x53) | PRO307 | 8.516 | 0.000 | +8.516 | HIGH |
| 18 | LEU68 (2.52x52) | TYR105 (3.35x35) | 0.000 | 8.465 | -8.465 | HIGH |
| 19 | ASN72 (2.56x56) | THR98 (3.28x28) | 0.000 | 8.275 | -8.275 | HIGH |
| 20 | THR251 (6.47x47) | ASN284 (7.45x45) | 0.000 | 8.264 | -8.264 | HIGH |
| 21 | PHE103 (3.33x33) | TYR177 | 9.787 | 1.617 | +8.170 | HIGH |
| 22 | TRP252 (6.48x48) | TYR281 (7.42x41) | 5.108 | 13.264 | -8.157 | HIGH |
| 23 | ARG212 (5.66x66) | TYR223 | 8.020 | 0.000 | +8.020 | HIGH |
| 24 | ASN313 | MET336 | 7.897 | 0.000 | +7.897 | HIGH |
| 25 | PHE197 (5.51x51) | ILE245 (6.41x41) | 1.441 | 9.086 | -7.645 | HIGH |
| 26 | TYR183 (5.37x37) | GLN259 (6.55x55) | 0.000 | 7.641 | -7.641 | HIGH |
| 27 | TYR110 (3.40x40) | TRP252 (6.48x48) | 0.000 | 7.596 | -7.596 | HIGH |
| 28 | VAL312 | TRP314 | 7.585 | 0.000 | +7.585 | HIGH |
| 29 | PHE248 (6.44x44) | TRP252 (6.48x48) | 2.287 | 9.857 | -7.570 | HIGH |
| 30 | SER182 (5.36x36) | GLU274 (7.35x34) | 7.322 | 0.000 | +7.322 | HIGH |
| 31 | PHE113 (3.43x43) | PHE248 (6.44x44) | 0.000 | 7.234 | -7.234 | HIGH |
| 32 | LYS35 (1.46x46) | ASP66 (2.50x50) | 7.207 | 0.000 | +7.207 | HIGH |
| 33 | TYR110 (3.40x40) | LEU193 (5.47x47) | 0.000 | 7.113 | -7.113 | HIGH |
| 34 | SER285 (7.46x46) | ASP309 | 7.073 | 0.000 | +7.073 | HIGH |
| 35 | THR214 (5.68x68) | ILE221 | 6.998 | 0.000 | +6.998 | HIGH |
| 36 | CYS121 (3.51x51) | CYS200 (5.54x54) | 0.000 | 6.988 | -6.988 | HIGH |
| 37 | ILE73 (2.57x57) | PHE282 (7.43x42) | 0.000 | 6.880 | -6.880 | HIGH |
| 38 | HIS109 (3.39x39) | MET275 (7.36x35) | 6.782 | 0.000 | +6.782 | HIGH |
| 39 | TYR153 (4.56x56) | LEU185 (5.39x39) | 0.000 | 6.734 | -6.734 | HIGH |
| 40 | GLN135 (4.38x38) | TYR139 (4.42x42) | 6.924 | 0.524 | +6.400 | HIGH |
| 41 | PHE107 (3.37x37) | GLN181 (5.35x35) | 6.356 | 0.000 | +6.356 | HIGH |
| 42 | TYR223 | PRO225 | 6.325 | 0.000 | +6.325 | HIGH |
| 43 | PHE58 (2.42x42) | ALA116 (3.46x46) | 0.000 | 6.315 | -6.315 | HIGH |
| 44 | PHE255 (6.51x51) | PHE282 (7.43x42) | 6.235 | 0.000 | +6.235 | HIGH |
| 45 | PHE54 (2.38x38) | THR115 (3.45x45) | 6.090 | 0.000 | +6.090 | HIGH |
| 46 | LYS243 (6.39x39) | CYS317 | 6.084 | 0.000 | +6.084 | HIGH |
| 47 | SER163 | TYR177 | 0.000 | 6.067 | -6.067 | HIGH |
| 48 | LEU108 (3.38x38) | TRP147 (4.50x50) | 2.765 | 8.707 | -5.942 | HIGH |
| 49 | PHE132 | LYS136 (4.39x39) | 5.808 | 0.000 | +5.808 | HIGH |
| 50 | TYR92 (3.22x22) | ASN168 | 8.924 | 3.197 | +5.726 | HIGH |
| 51 | LYS315 | MET336 | 5.671 | 0.000 | +5.671 | HIGH |
| 52 | PHE58 (2.42x42) | THR115 (3.45x45) | 0.000 | 5.573 | -5.573 | HIGH |
| 53 | LEU28 (1.39x39) | TRP279 (7.40x39) | 0.000 | 5.516 | -5.516 | HIGH |
| 54 | CYS51 | PHE318 | 0.000 | 5.511 | -5.511 | HIGH |
| 55 | ARG47 (1.58x58) | PRO310 | 5.499 | 0.000 | +5.499 | HIGH |
| 56 | HIS297 (8.48x48) | LYS298 (8.49x49) | 5.457 | 0.000 | +5.457 | HIGH |
| 57 | HIS109 (3.39x39) | SER182 (5.36x36) | 5.397 | 0.000 | +5.397 | HIGH |
| 58 | TYR281 (7.42x41) | PHE311 | 5.384 | 0.000 | +5.384 | HIGH |
| 59 | ASP66 (2.50x50) | TYR105 (3.35x35) | 5.351 | 0.000 | +5.351 | HIGH |
| 60 | LYS35 (1.46x46) | PHE282 (7.43x42) | 0.000 | 5.299 | -5.299 | HIGH |
| 61 | CYS59 (2.43x43) | TYR292 (7.53x53) | 0.000 | 5.260 | -5.260 | HIGH |
| 62 | VAL83 | LYS91 (3.21x21) | 0.000 | 5.211 | -5.211 | HIGH |
| 63 | ASN72 (2.56x56) | ILE101 (3.31x31) | 0.000 | 5.142 | -5.142 | HIGH |
| 64 | ALA210 (5.64x64) | PRO225 | 5.061 | 0.000 | +5.061 | HIGH |
| 65 | TYR78 (2.62x62) | PHE79 (2.63x63) | 4.937 | 0.000 | +4.937 | MED |
| 66 | PHE226 | LYS243 (6.39x39) | 4.877 | 0.000 | +4.877 | MED |
| 67 | SER102 (3.32x32) | TYR272 (7.33x32) | 4.737 | 0.000 | +4.737 | MED |
| 68 | PHE97 (3.27x27) | ILE101 (3.31x31) | 0.000 | 4.707 | -4.707 | MED |
| 69 | PHE255 (6.51x51) | GLN259 (6.55x55) | 4.331 | 8.986 | -4.655 | MED |
| 70 | TRP252 (6.48x48) | SER285 (7.46x46) | 4.481 | 0.000 | +4.481 | MED |
| 71 | TYR92 (3.22x22) | LEU164 | 0.508 | 4.867 | -4.359 | MED |
| 72 | CYS51 | GLU56 (2.40x40) | 0.369 | 4.708 | -4.339 | MED |
| 73 | ASN39 (1.50x50) | ALA63 (2.47x47) | 0.000 | 4.311 | -4.311 | MED |
| 74 | TRP201 (5.55x55) | SER242 (6.38x38) | 0.000 | 4.303 | -4.303 | MED |
| 75 | ARG80 (2.64x64) | ASP81 (2.65x65) | 0.000 | 4.296 | -4.296 | MED |
| 76 | TYR120 (3.50x50) | LEU241 (6.37x37) | 0.000 | 4.261 | -4.261 | MED |
| 77 | TYR120 (3.50x50) | ASN284 (7.45x45) | 4.260 | 0.000 | +4.260 | MED |
| 78 | PHE240 (6.36x36) | ASN295 (7.56x56) | 0.000 | 4.165 | -4.165 | MED |
| 79 | PHE248 (6.44x44) | PHE282 (7.43x42) | 4.121 | 0.000 | +4.121 | MED |
| 80 | PHE58 (2.42x42) | VAL112 (3.42x42) | 5.677 | 1.605 | +4.072 | MED |
| 81 | PHE255 (6.51x51) | TRP279 (7.40x39) | 4.070 | 0.000 | +4.070 | MED |
| 82 | TYR105 (3.35x35) | MET275 (7.36x35) | 4.046 | 0.000 | +4.046 | MED |
| 83 | PHE124 (3.54x54) | VAL208 (5.62x62) | 0.000 | 4.039 | -4.039 | MED |
| 84 | ASN53 (2.37x37) | TYR120 (3.50x50) | 4.032 | 0.000 | +4.032 | MED |
| 85 | PHE124 (3.54x54) | VAL204 (5.58x58) | 0.000 | 4.006 | -4.006 | MED |
| 86 | LYS126 (3.56x56) | ASP303 (8.54x54) | 3.941 | 0.000 | +3.941 | MED |
| 87 | VAL65 (2.49x49) | TYR105 (3.35x35) | 1.929 | 5.855 | -3.926 | MED |
| 88 | TYR26 (1.37x37) | LEU30 (1.41x41) | 0.315 | 4.221 | -3.906 | MED |
| 89 | TYR292 (7.53x53) | TRP314 | 3.900 | 0.000 | +3.900 | MED |
| 90 | LEU244 (6.40x40) | TRP314 | 3.879 | 0.000 | +3.879 | MED |
| 91 | TRP252 (6.48x48) | ASN284 (7.45x45) | 0.000 | 3.849 | -3.849 | MED |
| 92 | GLU203 (5.57x57) | LYS238 (6.34x34) | 3.826 | 0.000 | +3.826 | MED |
| 93 | TYR120 (3.50x50) | ILE288 (7.49x49) | 3.786 | 0.000 | +3.786 | MED |
| 94 | ASN276 (7.37x36) | PRO278 (7.39x38) | 3.759 | 0.000 | +3.759 | LOW |
| 95 | TYR177 | ALA271 (7.32x31) | 3.684 | 0.000 | +3.684 | LOW |
| 96 | LEU207 (5.61x61) | PHE224 | 3.665 | 0.000 | +3.665 | LOW |
| 97 | PHE113 (3.43x43) | LEU287 (7.48x48) | 3.649 | 0.000 | +3.649 | LOW |
| 98 | TYR110 (3.40x40) | VAL190 (5.44x44) | 0.000 | 3.637 | -3.637 | LOW |
| 99 | CYS59 (2.43x43) | ILE277 (7.38x37) | 3.629 | 0.000 | +3.629 | LOW |
| 100 | GLN52 | TYR57 (2.41x41) | 4.050 | 0.430 | +3.620 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 3.78 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 26-48 | 39 (10.9), 35 (7.2), 47 (5.5) | 3 | 28 (-5.5), 26 (-3.9), 30 (-3.9) | 3 |
| TM2 | 53-82 | 82 (13.6), 81 (9.2), 78 (4.9), 79 (4.9), 53 (4.0) | 5 | 66 (-9.6), 54 (-9.3), 68 (-8.5), 72 (-8.3), 73 (-6.9), 58 (-6.3), 59 (-5.3), 56 (-4.3), 63 (-4.3), 80 (-4.3), 65 (-3.9) | 11 |
| TM3 | 88-126 | 89 (13.6), 124 (9.7), 88 (9.2), 109 (8.8), 103 (8.2), 107 (6.4), 115 (6.1), 92 (5.7), 102 (4.7), 112 (4.1), 126 (3.9) | 11 | 105 (-8.5), 98 (-8.3), 110 (-7.6), 113 (-7.2), 121 (-7.0), 116 (-6.3), 108 (-5.9), 91 (-5.2), 101 (-5.1), 97 (-4.7), 120 (-4.3) | 11 |
| TM4 | 135-153 | 139 (6.4), 136 (5.8) | 2 | 135 (-9.3), 153 (-6.7), 147 (-5.9) | 3 |
| TM5 | 181-214 | 189 (8.7), 212 (8.0), 182 (7.3), 214 (7.0), 181 (6.4), 210 (5.1), 203 (3.8) | 7 | 183 (-14.8), 207 (-9.4), 197 (-7.6), 193 (-7.1), 200 (-7.0), 185 (-6.7), 201 (-4.3), 208 (-4.0), 204 (-4.0) | 9 |
| TM6 | 237-262 | 237 (15.4), 252 (10.2), 241 (9.7), 243 (6.1), 244 (3.9), 238 (3.8) | 6 | 255 (-16.8), 251 (-8.3), 245 (-7.6), 259 (-7.6), 248 (-7.6), 242 (-4.3), 240 (-4.2) | 7 |
| TM7 | 270-295 | 293 (15.4), 277 (10.9), 282 (10.2), 295 (9.7), 292 (9.6), 279 (8.8), 286 (8.7), 274 (7.3), 275 (6.8), 272 (4.7), 288 (3.8) | 11 | 281 (-16.8), 285 (-9.6), 284 (-8.3) | 3 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 50-52 | - | 0 | 51 (-5.5) | 1 |
| ICL2 | 132-132 | 132 (5.8) | 1 | - | 0 |
| ICL3 | 221-226 | 223 (8.0), 221 (7.0), 225 (6.3), 226 (4.9) | 4 | - | 0 |
| ECL1 | 83-83 | - | 0 | 83 (-5.2) | 1 |
| ECL2 | 163-179 | 177 (8.2), 168 (5.7) | 2 | 178 (-14.8), 163 (-6.1), 164 (-4.4) | 3 |
| ECL3 | 267-267 | - | 0 | - | 0 |
| H8 | 297-306 | 306 (9.6), 297 (5.5), 298 (5.5), 303 (3.9) | 4 | 300 (-10.3) | 1 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
172 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 281 | p.Tyr281His | c.841T>C | 2.54e-05 | 37 / 0 | 16.75 | 0.473 | AMBIGUOUS | 0.89 | rs146297186 |
| 281 | p.Tyr281Phe | c.842A>T | 6.87e-07 | 1 / 0 | 16.75 | - | nan | - | rs1713340472 |
| 293 | p.Trp293Gly | c.877T>G | 6.86e-07 | 1 / 0 | 15.45 | 0.233 | BENIGN | 0.97 | |
| 237 | p.Lys237Glu | c.709A>G | 6.86e-07 | 1 / 0 | 15.45 | 0.120 | BENIGN | 0.80 | |
| 237 | p.Lys237Arg | c.710A>G | 6.85e-07 | 1 / 0 | 15.45 | - | nan | - | |
| 237 | p.Lys237Thr | c.710A>C | 4.80e-06 | 7 / 0 | 15.45 | - | nan | - | rs758830676 |
| 293 | p.Trp293Leu | c.878G>T | 4.80e-06 | 7 / 0 | 15.45 | - | nan | - | |
| 293 | p.Trp293Cys | c.879G>T | 2.06e-06 | 3 / 0 | 15.45 | - | nan | - | rs757623733 |
| 178 | p.Val178Ile | c.532G>A | 3.42e-06 | 5 / 0 | 14.81 | 0.076 | BENIGN | 0.59 | |
| 178 | p.Val178Asp | c.533T>A | 6.57e-06 | 1 / 0 | 14.81 | - | nan | - | rs1713313498 |
| 89 | p.Phe89Ile | c.265T>A | 2.75e-06 | 4 / 0 | 13.61 | 0.250 | BENIGN | 0.95 | |
| 39 | p.Asn39Ser | c.116A>G | 2.08e-06 | 3 / 0 | 10.86 | 0.285 | BENIGN | 0.76 | rs1216469547 |
| 317 | p.Cys317Arg | c.949T>C | 2.00e-05 | 29 / 0 | 10.30 | 0.790 | PATHOGENIC | 1.00 | rs757231798 |
| 317 | p.Cys317Tyr | c.950G>A | 6.89e-07 | 1 / 0 | 10.30 | - | nan | - | |
| 252 | p.Trp252Cys | c.756G>C | 6.85e-07 | 1 / 0 | 10.17 | 0.923 | PATHOGENIC | 0.97 | |
| 241 | p.Leu241Val | c.721T>G | 6.85e-07 | 1 / 0 | 9.69 | 0.143 | BENIGN | 0.90 | |
| 292 | p.Tyr292Asp | c.874T>G | 4.25e-05 | 56 / 3 | 9.65 | 0.451 | AMBIGUOUS | 0.82 | rs552972161 |
| 66 | p.Asp66Tyr | c.196G>T | 6.95e-07 | 1 / 0 | 9.59 | 0.844 | PATHOGENIC | 0.96 | |
| 66 | p.Asp66His | c.196G>C | 4.87e-06 | 7 / 0 | 9.59 | - | nan | - | rs935869795 |
| 66 | p.Asp66Glu | c.198T>A | 4.86e-06 | 7 / 0 | 9.59 | - | nan | - | rs780774360 |
| 207 | p.Leu207Phe | c.621G>C | 3.42e-06 | 5 / 0 | 9.39 | 0.141 | BENIGN | 0.68 | rs1420134306 |
| 54 | p.Phe54Leu | c.160T>C | 7.63e-06 | 11 / 0 | 9.34 | 0.559 | AMBIGUOUS | 0.92 | rs561664509 |
| 81 | p.Asp81Asn | c.241G>A | 3.45e-06 | 5 / 0 | 9.20 | 0.313 | BENIGN | 0.98 | rs763587492 |
| 88 | p.Arg88Trp | c.262A>T | 6.88e-07 | 1 / 0 | 9.20 | 0.253 | BENIGN | 0.98 | |
| 279 | p.Trp279Arg | c.835T>C | 1.37e-06 | 2 / 0 | 8.85 | 0.974 | PATHOGENIC | 0.98 | |
| 109 | p.His109Asn | c.325C>A | 4.12e-06 | 6 / 0 | 8.85 | 0.268 | BENIGN | 0.82 | rs751350978 |
| 286 | p.Phe286Leu | c.856T>C | 4.12e-06 | 6 / 0 | 8.69 | 0.821 | PATHOGENIC | 1.00 | rs139558562 |
| 189 | p.Met189Lys | c.566T>A | 1.37e-06 | 2 / 0 | 8.69 | 0.679 | PATHOGENIC | 0.88 | |
| 189 | p.Met189Ile | c.567G>C | 6.57e-06 | 1 / 0 | 8.69 | - | nan | - | rs1713317028 |
| 68 | p.Leu68Ser | c.203T>C | 6.95e-07 | 1 / 0 | 8.47 | 0.263 | BENIGN | 0.54 | |
| 105 | p.Tyr105Cys | c.314A>G | 4.12e-06 | 6 / 0 | 8.47 | 0.127 | BENIGN | 0.93 | rs750308860 |
| 98 | p.Thr98Ala | c.292A>G | 6.87e-07 | 1 / 0 | 8.27 | 0.127 | BENIGN | 0.71 | rs752908305 |
| 251 | p.Thr251Pro | c.751A>C | 2.06e-06 | 3 / 0 | 8.26 | 0.272 | BENIGN | 0.96 | rs1277998248 |
| 284 | p.Asn284Ser | c.851A>G | 6.86e-07 | 1 / 0 | 8.26 | 0.230 | BENIGN | 0.97 | rs1713341347 |
| 251 | p.Thr251Asn | c.752C>A | 2.06e-06 | 3 / 0 | 8.26 | - | nan | - | |
| 103 | p.Phe103Leu | c.307T>C | 6.86e-07 | 1 / 0 | 8.17 | 0.397 | AMBIGUOUS | 0.66 | |
| 177 | p.Tyr177Cys | c.530A>G | 2.74e-06 | 4 / 0 | 8.17 | 0.168 | BENIGN | 0.85 | rs1467059911 |
| 103 | p.Phe103Val | c.307T>G | 6.86e-07 | 1 / 0 | 8.17 | - | nan | - | |
| 223 | p.Tyr223His | c.667T>C | 6.85e-07 | 1 / 0 | 8.02 | 0.230 | BENIGN | 0.53 | rs774305246 |
| 313 | p.Asn313His | c.937A>C | 6.87e-07 | 1 / 0 | 7.90 | 0.117 | BENIGN | 0.69 | |
| 336 | p.Met336Leu | c.1006A>C | 7.58e-07 | 1 / 0 | 7.90 | 0.085 | BENIGN | 0.82 | |
| 313 | p.Asn313Ser | c.938A>G | 6.87e-07 | 1 / 0 | 7.90 | - | nan | - | rs1396086499 |
| 313 | p.Asn313Lys | c.939C>A | 6.89e-07 | 1 / 0 | 7.90 | - | nan | - | |
| 336 | p.Met336Thr | c.1007T>C | 1.51e-06 | 2 / 0 | 7.90 | - | nan | - | rs1713352964 |
| 336 | p.Met336Ile | c.1008G>A | 6.57e-06 | 1 / 0 | 7.90 | - | nan | - | rs1713353131 |
| 336 | p.Met336Ile | c.1008G>T | 7.65e-07 | 1 / 0 | 7.90 | - | nan | - | rs1713353131 |
| 245 | p.Ile245Leu | c.733A>C | 2.05e-06 | 3 / 0 | 7.64 | 0.066 | BENIGN | 0.70 | |
| 245 | p.Ile245Thr | c.734T>C | 6.16e-06 | 9 / 0 | 7.64 | - | nan | - | rs1559995901 |
| 110 | p.Tyr110His | c.328T>C | 1.37e-06 | 2 / 0 | 7.60 | 0.470 | AMBIGUOUS | 0.88 | |
| 314 | p.Trp314Arg | c.940T>C | 6.56e-06 | 1 / 0 | 7.58 | 0.975 | PATHOGENIC | 1.00 | rs546087919 |
| 312 | p.Val312Ile | c.934G>A | 6.87e-07 | 1 / 0 | 7.58 | 0.106 | BENIGN | 0.92 | rs1317169069 |
| 314 | p.Trp314Cys | c.942G>C | 2.75e-06 | 4 / 0 | 7.58 | - | nan | - | rs753058492 |
| 182 | p.Ser182Arg | c.544A>C | 4.11e-06 | 6 / 0 | 7.32 | 0.912 | PATHOGENIC | 0.90 | rs752346866 |
| 274 | p.Glu274Gln | c.820G>C | 6.57e-06 | 1 / 0 | 7.32 | 0.410 | AMBIGUOUS | 0.92 | rs142366644 |
| 182 | p.Ser182Cys | c.544A>T | 6.85e-07 | 1 / 0 | 7.32 | - | nan | - | rs752346866 |
| 182 | p.Ser182Asn | c.545G>A | 6.85e-07 | 1 / 0 | 7.32 | - | nan | - | |
| 274 | p.Glu274Lys | c.820G>A | 1.92e-04 | 278 / 0 | 7.32 | - | nan | - | rs142366644 |
| 274 | p.Glu274Asp | c.822G>C | 1.38e-06 | 2 / 0 | 7.32 | - | nan | - | |
| 113 | p.Phe113Val | c.337T>G | 6.86e-07 | 1 / 0 | 7.23 | 0.102 | BENIGN | 0.63 | |
| 113 | p.Phe113Leu | c.337T>C | 6.57e-06 | 1 / 0 | 7.23 | - | nan | - | rs1713296101 |
| 35 | p.Lys35Glu | c.103A>G | 6.95e-07 | 1 / 0 | 7.21 | 0.860 | PATHOGENIC | 1.00 | |
| 35 | p.Lys35Thr | c.104A>C | 6.97e-07 | 1 / 0 | 7.21 | - | nan | - | |
| 309 | p.Asp309Glu | c.927T>G | 6.87e-07 | 1 / 0 | 7.07 | 0.818 | PATHOGENIC | 1.00 | rs1713345942 |
| 214 | p.Thr214Ala | c.640A>G | 6.85e-07 | 1 / 0 | 7.00 | 0.085 | BENIGN | 0.57 | |
| 221 | p.Ile221Val | c.661A>G | 7.54e-05 | 110 / 0 | 7.00 | 0.063 | BENIGN | 0.71 | rs570236318 |
| 214 | p.Thr214Ile | c.641C>T | 1.10e-05 | 16 / 0 | 7.00 | - | nan | - | rs1463476651 |
| 221 | p.Ile221Thr | c.662T>C | 6.85e-07 | 1 / 0 | 7.00 | - | nan | - | |
| 200 | p.Cys200Arg | c.598T>C | 6.85e-07 | 1 / 0 | 6.99 | 0.246 | BENIGN | 0.61 | rs779527847 |
| 121 | p.Cys121Tyr | c.362G>A | 6.87e-07 | 1 / 0 | 6.99 | 0.074 | BENIGN | 0.68 | |
| 200 | p.Cys200Phe | c.599G>T | 2.05e-06 | 3 / 0 | 6.99 | - | nan | - | rs746390452 |
| 73 | p.Ile73Phe | c.217A>T | 6.95e-07 | 1 / 0 | 6.88 | 0.157 | BENIGN | 0.77 | |
| 153 | p.Tyr153Asn | c.457T>A | 1.37e-06 | 2 / 0 | 6.73 | 0.312 | BENIGN | 0.74 | rs1230867276 |
| 153 | p.Tyr153Cys | c.458A>G | 2.06e-06 | 3 / 0 | 6.73 | - | nan | - | rs775737762 |
| 139 | p.Tyr139His | c.415T>C | 6.87e-07 | 1 / 0 | 6.40 | 0.248 | BENIGN | 0.98 | rs1477269542 |
| 181 | p.Gln181Arg | c.542A>G | 3.42e-06 | 5 / 0 | 6.36 | 0.419 | AMBIGUOUS | 0.99 | |
| 225 | p.Pro225Thr | c.673C>A | 1.37e-06 | 2 / 0 | 6.32 | 0.196 | BENIGN | 0.72 | rs1337223138 |
| 115 | p.Thr115Lys | c.344C>A | 6.87e-07 | 1 / 0 | 6.09 | 0.448 | AMBIGUOUS | 0.62 | |
| 163 | p.Ser163Arg | c.489C>G | 6.84e-07 | 1 / 0 | 6.07 | 0.327 | BENIGN | 0.54 | |
| 147 | p.Trp147Arg | c.439T>C | 2.75e-06 | 4 / 0 | 5.94 | 0.978 | PATHOGENIC | 1.00 | rs1713307976 |
| 132 | p.Phe132Leu | c.394T>C | 1.37e-06 | 2 / 0 | 5.81 | 0.276 | BENIGN | 0.36 | rs1477637227 |
| 136 | p.Lys136Glu | c.406A>G | 6.87e-07 | 1 / 0 | 5.81 | 0.176 | BENIGN | 0.71 | |
| 132 | p.Phe132Cys | c.395T>G | 6.25e-05 | 91 / 0 | 5.81 | - | nan | - | rs201952152 |
| 168 | p.Asn168Ser | c.503A>G | 6.84e-07 | 1 / 0 | 5.73 | 0.081 | BENIGN | 0.70 | rs1450072939 |
| 315 | p.Lys315Glu | c.943A>G | 6.87e-07 | 1 / 0 | 5.67 | 0.179 | BENIGN | 0.93 | |
| 315 | p.Lys315Asn | c.945G>C | 1.31e-05 | 19 / 0 | 5.67 | - | nan | - | rs756561779 |
| 318 | p.Phe318Cys | c.953T>G | 6.90e-07 | 1 / 0 | 5.51 | 0.370 | AMBIGUOUS | 0.97 | |
| 51 | p.Cys51Gly | c.151T>G | 6.94e-07 | 1 / 0 | 5.51 | 0.069 | BENIGN | 0.43 | rs1396319257 |
| 51 | p.Cys51Tyr | c.152G>A | 6.93e-07 | 1 / 0 | 5.51 | - | nan | - | |
| 310 | p.Pro310Leu | c.929C>T | 6.88e-07 | 1 / 0 | 5.50 | 0.490 | AMBIGUOUS | 0.95 | rs1282874467 |
| 47 | p.Arg47Gly | c.139A>G | 6.92e-07 | 1 / 0 | 5.50 | 0.217 | BENIGN | 0.68 | |
| 47 | p.Arg47Lys | c.140G>A | 6.92e-07 | 1 / 0 | 5.50 | - | nan | - | |
| 47 | p.Arg47Thr | c.140G>C | 6.92e-07 | 1 / 0 | 5.50 | - | nan | - | rs1434950550 |
| 297 | p.His297Asn | c.889C>A | 6.86e-07 | 1 / 0 | 5.46 | 0.090 | BENIGN | 0.80 | |
| 297 | p.His297Gln | c.891C>G | 2.74e-06 | 4 / 0 | 5.46 | - | nan | - | rs762337181 |
| 311 | p.Phe311Leu | c.931T>C | 2.07e-06 | 3 / 0 | 5.38 | 0.957 | PATHOGENIC | 0.99 | |
| 59 | p.Cys59Arg | c.175T>C | 1.11e-05 | 16 / 0 | 5.26 | 0.876 | PATHOGENIC | 0.92 | rs1225027388 |
| 91 | p.Lys91Ile | c.272A>T | 3.30e-05 | 48 / 0 | 5.21 | 0.296 | BENIGN | 0.72 | rs774871816 |
| 83 | p.Val83Ala | c.248T>C | 6.90e-07 | 1 / 0 | 5.21 | 0.226 | BENIGN | 0.62 | |
| 101 | p.Ile101Thr | c.302T>C | 1.37e-06 | 2 / 0 | 5.14 | 0.171 | BENIGN | 0.70 | rs760773527 |
| 210 | p.Ala210Thr | c.628G>A | 6.85e-07 | 1 / 0 | 5.06 | 0.111 | BENIGN | 0.64 | rs776896213 |
| 210 | p.Ala210Pro | c.628G>C | 6.85e-07 | 1 / 0 | 5.06 | - | nan | - | |
| 210 | p.Ala210Val | c.629C>T | 6.85e-07 | 1 / 0 | 5.06 | - | nan | - | |
| 78 | p.Tyr78Asn | c.232T>A | 6.93e-07 | 1 / 0 | 4.94 | 0.209 | BENIGN | 0.81 | |
| 226 | p.Phe226Leu | c.678T>G | 1.03e-05 | 15 / 0 | 4.88 | 0.462 | AMBIGUOUS | 0.65 | rs752442376 |
| 272 | p.Tyr272His | c.814T>C | 1.38e-06 | 2 / 0 | 4.74 | 0.421 | AMBIGUOUS | 0.91 | rs1288560804 |
| 272 | p.Tyr272Cys | c.815A>G | 9.64e-06 | 14 / 0 | 4.74 | - | nan | - | rs757984039 |
| 97 | p.Phe97Leu | c.289T>C | 1.37e-06 | 2 / 0 | 4.71 | 0.393 | AMBIGUOUS | 0.73 | rs767779474 |
| 97 | p.Phe97Ser | c.290T>C | 2.95e-05 | 43 / 0 | 4.71 | - | nan | - | rs1315683462 |
| 56 | p.Glu56Ala | c.167A>C | 6.94e-07 | 1 / 0 | 4.34 | 0.135 | BENIGN | 0.56 | rs1440995882 |
| 242 | p.Ser242Tyr | c.725C>A | 4.11e-06 | 4 / 1 | 4.30 | 0.337 | BENIGN | 0.58 | rs544108325 |
| 80 | p.Arg80Thr | c.239G>C | 2.42e-05 | 35 / 0 | 4.30 | 0.166 | BENIGN | 0.62 | rs189341039 |
| 120 | p.Tyr120His | c.358T>C | 6.86e-07 | 1 / 0 | 4.26 | 0.168 | BENIGN | 0.90 | rs1337965095 |
| 120 | p.Tyr120Asn | c.358T>A | 6.86e-07 | 1 / 0 | 4.26 | - | nan | - | |
| 120 | p.Tyr120Phe | c.359A>T | 6.87e-07 | 1 / 0 | 4.26 | - | nan | - | rs1217586940 |
| 240 | p.Phe240Leu | c.718T>C | 6.85e-07 | 1 / 0 | 4.16 | 0.153 | BENIGN | 0.72 | |
| 112 | p.Val112Ala | c.335T>C | 6.86e-07 | 1 / 0 | 4.07 | 0.522 | AMBIGUOUS | 0.92 | rs1399035724 |
| 208 | p.Val208Leu | c.622G>T | 6.84e-07 | 1 / 0 | 4.04 | 0.117 | BENIGN | 0.69 | |
| 208 | p.Val208Ile | c.622G>A | 1.16e-05 | 17 / 0 | 4.04 | - | nan | - | rs747186938 |
| 208 | p.Val208Ala | c.623T>C | 6.84e-07 | 1 / 0 | 4.04 | - | nan | - | rs768860730 |
| 53 | p.Asn53Ser | c.158A>G | 2.08e-06 | 3 / 0 | 4.03 | 0.086 | BENIGN | 0.62 | rs201325990 |
| 53 | p.Asn53Lys | c.159T>G | 3.47e-06 | 5 / 0 | 4.03 | - | nan | - | rs1437370970 |
| 204 | p.Val204Ile | c.610G>A | 6.84e-07 | 1 / 0 | 4.01 | 0.091 | BENIGN | 0.92 | rs1713320778 |
| 126 | p.Lys126Glu | c.376A>G | 6.86e-07 | 1 / 0 | 3.94 | 0.094 | BENIGN | 0.63 | |
| 126 | p.Lys126Arg | c.377A>G | 6.86e-07 | 1 / 0 | 3.94 | - | nan | - | rs1198480507 |
| 126 | p.Lys126Ile | c.377A>T | 1.37e-06 | 2 / 0 | 3.94 | - | nan | - | rs1198480507 |
| 65 | p.Val65Ile | c.193G>A | 4.56e-04 | 652 / 2 | 3.93 | 0.081 | BENIGN | 0.53 | rs61745703 |
| 65 | p.Val65Ala | c.194T>C | 1.39e-06 | 2 / 0 | 3.93 | - | nan | - | rs768358306 |
| 26 | p.Tyr26His | c.76T>C | 3.49e-06 | 5 / 0 | 3.91 | 0.119 | BENIGN | 0.63 | rs1297664409 |
| 244 | p.Leu244Phe | c.730C>T | 8.15e-05 | 119 / 0 | 3.88 | 0.146 | BENIGN | 0.88 | rs747320666 |
| 244 | p.Leu244Arg | c.731T>G | 6.85e-07 | 1 / 0 | 3.88 | - | nan | - | |
| 203 | p.Glu203Val | c.608A>T | 6.84e-06 | 10 / 0 | 3.83 | 0.233 | BENIGN | 0.96 | rs758963706 |
| 238 | p.Lys238Ile | c.713A>T | 6.85e-07 | 1 / 0 | 3.83 | 0.203 | BENIGN | 0.51 | |
| 203 | p.Glu203Gly | c.608A>G | 6.84e-07 | 1 / 0 | 3.83 | - | nan | - | |
| 238 | p.Lys238Asn | c.714A>T | 6.85e-07 | 1 / 0 | 3.83 | - | nan | - | |
| 288 | p.Ile288Thr | c.863T>C | 6.17e-06 | 9 / 0 | 3.79 | 0.141 | BENIGN | 0.87 | rs776570089 |
| 278 | p.Pro278Ser | c.832C>T | 6.88e-07 | 1 / 0 | 3.76 | 0.604 | PATHOGENIC | 0.95 | rs1332442668 |
| 276 | p.Asn276Ser | c.827A>G | 6.88e-07 | 1 / 0 | 3.76 | 0.545 | AMBIGUOUS | 0.98 | rs1283057102 |
| 271 | p.Ala271Val | c.812C>T | 7.59e-06 | 11 / 0 | 3.68 | 0.606 | PATHOGENIC | 0.93 | |
| 57 | p.Tyr57Asp | c.169T>G | 6.95e-07 | 1 / 0 | 3.62 | 0.332 | BENIGN | 0.81 | rs1310679892 |
| 52 | p.Gln52Arg | c.155A>G | 6.93e-07 | 1 / 0 | 3.62 | 0.072 | BENIGN | 0.45 | |
| 52 | p.Gln52His | c.156A>C | 1.39e-06 | 2 / 0 | 3.62 | - | nan | - | rs1559995184 |
| 57 | p.Tyr57Asn | c.169T>A | 3.47e-06 | 5 / 0 | 3.62 | - | nan | - | rs1310679892 |
| 50 | p.Thr50Asn | c.149C>A | 6.57e-06 | 1 / 0 | 3.61 | 0.081 | BENIGN | 0.52 | rs1713282566 |
| 50 | p.Thr50Ile | c.149C>T | 6.93e-07 | 1 / 0 | 3.61 | - | nan | - | rs1713282566 |
| 76 | p.Ile76Val | c.226A>G | 2.78e-06 | 4 / 0 | 3.59 | 0.179 | BENIGN | 0.83 | rs769237975 |
| 76 | p.Ile76Thr | c.227T>C | 2.08e-06 | 3 / 0 | 3.59 | - | nan | - | rs1713288692 |
| 48 | p.Lys48Glu | c.142A>G | 1.11e-05 | 16 / 0 | 3.57 | 0.139 | BENIGN | 0.78 | rs201983549 |
| 316 | p.Cys316Tyr | c.947G>A | 1.38e-06 | 2 / 0 | 3.49 | 0.118 | BENIGN | 0.64 | rs749569388 |
| 111 | p.Pro111Leu | c.332C>T | 2.06e-06 | 3 / 0 | 3.46 | 0.404 | AMBIGUOUS | 0.95 | rs1713295417 |
| 270 | p.Pro270Ala | c.808C>G | 1.86e-05 | 27 / 0 | 3.42 | 0.503 | AMBIGUOUS | 1.00 | rs749894318 |
| 176 | p.Phe176Cys | c.527T>G | 3.83e-05 | 56 / 0 | 3.42 | 0.182 | BENIGN | 0.61 | rs192710143 |
| 176 | p.Phe176Ser | c.527T>C | 4.79e-06 | 7 / 0 | 3.42 | - | nan | - | rs192710143 |
| 270 | p.Pro270Ser | c.808C>T | 4.82e-06 | 7 / 0 | 3.42 | - | nan | - | rs749894318 |
| 70 | p.Leu70Ser | c.209T>C | 6.96e-07 | 1 / 0 | 3.33 | 0.410 | AMBIGUOUS | 0.96 | |
| 42 | p.Thr42Pro | c.124A>C | 6.56e-06 | 1 / 0 | 3.32 | 0.271 | BENIGN | 0.56 | rs564322229 |
| 42 | p.Thr42Ile | c.125C>T | 6.93e-06 | 10 / 0 | 3.32 | - | nan | - | |
| 106 | p.Gly106Asp | c.317G>A | 1.37e-06 | 2 / 0 | 3.26 | 0.743 | PATHOGENIC | 0.87 | |
| 179 | p.Ser179Thr | c.536G>C | 1.37e-06 | 2 / 0 | 3.26 | 0.268 | BENIGN | 0.95 | |
| 179 | p.Ser179Asn | c.536G>A | 6.84e-07 | 1 / 0 | 3.26 | - | nan | - | |
| 99 | p.Gln99Arg | c.296A>G | 1.37e-06 | 2 / 0 | 3.21 | 0.308 | BENIGN | 0.92 | |
| 167 | p.Gln167Lys | c.499C>A | 1.44e-05 | 21 / 0 | 3.21 | 0.075 | BENIGN | 0.69 | rs1034414232 |
| 36 | p.Ile36Leu | c.106A>T | 6.13e-05 | 88 / 0 | 3.17 | 0.152 | BENIGN | 0.73 | rs137932976 |
| 36 | p.Ile36Val | c.106A>G | 1.39e-06 | 2 / 0 | 3.17 | - | nan | - | rs137932976 |
| 267 | p.Val267Ile | c.799G>A | 6.87e-07 | 1 / 0 | 3.15 | 0.101 | BENIGN | 0.68 | rs1713336236 |
| 262 | p.Ile262Thr | c.785T>C | 4.81e-06 | 7 / 0 | 3.15 | 0.076 | BENIGN | 0.85 | rs759452986 |
| 267 | p.Val267Leu | c.799G>C | 6.87e-07 | 1 / 0 | 3.15 | - | nan | - | |
| 114 | p.Leu114Val | c.340C>G | 6.86e-07 | 1 / 0 | 3.10 | 0.091 | BENIGN | 0.85 | |
| 94 | p.Ile94Leu | c.280A>C | 6.87e-07 | 1 / 0 | 3.10 | 0.208 | BENIGN | 0.97 | rs1233343205 |
| 186 | p.Ser186Ala | c.556T>G | 1.16e-05 | 17 / 0 | 3.08 | 0.102 | BENIGN | 1.00 | rs777355592 |
| 283 | p.Val283Ile | c.847G>A | 2.06e-06 | 3 / 0 | 3.07 | 0.091 | BENIGN | 0.78 | |
| 283 | p.Val283Phe | c.847G>T | 6.87e-07 | 1 / 0 | 3.07 | - | nan | - | rs534725792 |
| 283 | p.Val283Leu | c.847G>C | 3.23e-05 | 47 / 0 | 3.07 | - | nan | - | rs534725792 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 3.78, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 255 | PHE | 281 | TYR | 0.000 | 16.752 | -16.752 | 16.752 |
| 237 | LYS | 293 | TRP | 15.447 | 0.000 | 15.447 | 15.447 |
| 178 | VAL | 183 | TYR | 0.000 | 14.812 | -14.812 | 14.812 |
| 82 | PHE | 89 | PHE | 13.609 | 0.000 | 13.609 | 13.609 |
| 39 | ASN | 277 | ILE | 10.855 | 0.000 | 10.855 | 10.855 |
| 300 | ASN | 317 | CYS | 0.000 | 10.302 | -10.302 | 10.302 |
| 252 | TRP | 282 | PHE | 10.169 | 0.000 | 10.169 | 10.169 |
| 124 | PHE | 295 | ASN | 9.723 | 0.000 | 9.723 | 9.723 |
| 241 | LEU | 293 | TRP | 9.687 | 0.000 | 9.687 | 9.687 |
| 292 | TYR | 306 | LEU | 9.647 | 0.000 | 9.647 | 9.647 |
| 66 | ASP | 285 | SER | 0.000 | 9.591 | -9.591 | 9.591 |
| 124 | PHE | 207 | LEU | 0.000 | 9.392 | -9.392 | 9.392 |
| 54 | PHE | 135 | GLN | 0.000 | 9.338 | -9.338 | 9.338 |
| 81 | ASP | 88 | ARG | 9.199 | 0.000 | 9.199 | 9.199 |
| 109 | HIS | 279 | TRP | 8.847 | 0.000 | 8.847 | 8.847 |
| 189 | MET | 286 | PHE | 8.690 | 0.000 | 8.690 | 8.690 |
| 292 | TYR | 307 | PRO | 8.516 | 0.000 | 8.516 | 8.516 |
| 68 | LEU | 105 | TYR | 0.000 | 8.465 | -8.465 | 8.465 |
| 72 | ASN | 98 | THR | 0.000 | 8.275 | -8.275 | 8.275 |
| 251 | THR | 284 | ASN | 0.000 | 8.264 | -8.264 | 8.264 |
| 103 | PHE | 177 | TYR | 9.787 | 1.617 | 8.170 | 8.170 |
| 252 | TRP | 281 | TYR | 5.108 | 13.264 | -8.157 | 8.157 |
| 212 | ARG | 223 | TYR | 8.020 | 0.000 | 8.020 | 8.020 |
| 313 | ASN | 336 | MET | 7.897 | 0.000 | 7.897 | 7.897 |
| 197 | PHE | 245 | ILE | 1.441 | 9.086 | -7.645 | 7.645 |
| 183 | TYR | 259 | GLN | 0.000 | 7.641 | -7.641 | 7.641 |
| 110 | TYR | 252 | TRP | 0.000 | 7.596 | -7.596 | 7.596 |
| 312 | VAL | 314 | TRP | 7.585 | 0.000 | 7.585 | 7.585 |
| 248 | PHE | 252 | TRP | 2.287 | 9.857 | -7.570 | 7.570 |
| 182 | SER | 274 | GLU | 7.322 | 0.000 | 7.322 | 7.322 |
| 113 | PHE | 248 | PHE | 0.000 | 7.234 | -7.234 | 7.234 |
| 35 | LYS | 66 | ASP | 7.207 | 0.000 | 7.207 | 7.207 |
| 110 | TYR | 193 | LEU | 0.000 | 7.113 | -7.113 | 7.113 |
| 285 | SER | 309 | ASP | 7.073 | 0.000 | 7.073 | 7.073 |
| 214 | THR | 221 | ILE | 6.998 | 0.000 | 6.998 | 6.998 |
| 121 | CYS | 200 | CYS | 0.000 | 6.988 | -6.988 | 6.988 |
| 73 | ILE | 282 | PHE | 0.000 | 6.880 | -6.880 | 6.880 |
| 109 | HIS | 275 | MET | 6.782 | 0.000 | 6.782 | 6.782 |
| 153 | TYR | 185 | LEU | 0.000 | 6.734 | -6.734 | 6.734 |
| 135 | GLN | 139 | TYR | 6.924 | 0.524 | 6.400 | 6.400 |
| 107 | PHE | 181 | GLN | 6.356 | 0.000 | 6.356 | 6.356 |
| 223 | TYR | 225 | PRO | 6.325 | 0.000 | 6.325 | 6.325 |
| 58 | PHE | 116 | ALA | 0.000 | 6.315 | -6.315 | 6.315 |
| 255 | PHE | 282 | PHE | 6.235 | 0.000 | 6.235 | 6.235 |
| 54 | PHE | 115 | THR | 6.090 | 0.000 | 6.090 | 6.090 |
| 243 | LYS | 317 | CYS | 6.084 | 0.000 | 6.084 | 6.084 |
| 163 | SER | 177 | TYR | 0.000 | 6.067 | -6.067 | 6.067 |
| 108 | LEU | 147 | TRP | 2.765 | 8.707 | -5.942 | 5.942 |
| 132 | PHE | 136 | LYS | 5.808 | 0.000 | 5.808 | 5.808 |
| 92 | TYR | 168 | ASN | 8.924 | 3.197 | 5.726 | 5.726 |
| 315 | LYS | 336 | MET | 5.671 | 0.000 | 5.671 | 5.671 |
| 58 | PHE | 115 | THR | 0.000 | 5.573 | -5.573 | 5.573 |
| 28 | LEU | 279 | TRP | 0.000 | 5.516 | -5.516 | 5.516 |
| 51 | CYS | 318 | PHE | 0.000 | 5.511 | -5.511 | 5.511 |
| 47 | ARG | 310 | PRO | 5.499 | 0.000 | 5.499 | 5.499 |
| 297 | HIS | 298 | LYS | 5.457 | 0.000 | 5.457 | 5.457 |
| 109 | HIS | 182 | SER | 5.397 | 0.000 | 5.397 | 5.397 |
| 281 | TYR | 311 | PHE | 5.384 | 0.000 | 5.384 | 5.384 |
| 66 | ASP | 105 | TYR | 5.351 | 0.000 | 5.351 | 5.351 |
| 35 | LYS | 282 | PHE | 0.000 | 5.299 | -5.299 | 5.299 |
| 59 | CYS | 292 | TYR | 0.000 | 5.260 | -5.260 | 5.260 |
| 83 | VAL | 91 | LYS | 0.000 | 5.211 | -5.211 | 5.211 |
| 72 | ASN | 101 | ILE | 0.000 | 5.142 | -5.142 | 5.142 |
| 210 | ALA | 225 | PRO | 5.061 | 0.000 | 5.061 | 5.061 |
| 78 | TYR | 79 | PHE | 4.937 | 0.000 | 4.937 | 4.937 |
| 226 | PHE | 243 | LYS | 4.877 | 0.000 | 4.877 | 4.877 |
| 102 | SER | 272 | TYR | 4.737 | 0.000 | 4.737 | 4.737 |
| 97 | PHE | 101 | ILE | 0.000 | 4.707 | -4.707 | 4.707 |
| 255 | PHE | 259 | GLN | 4.331 | 8.986 | -4.655 | 4.655 |
| 252 | TRP | 285 | SER | 4.481 | 0.000 | 4.481 | 4.481 |
| 92 | TYR | 164 | LEU | 0.508 | 4.867 | -4.359 | 4.359 |
| 51 | CYS | 56 | GLU | 0.369 | 4.708 | -4.339 | 4.339 |
| 39 | ASN | 63 | ALA | 0.000 | 4.311 | -4.311 | 4.311 |
| 201 | TRP | 242 | SER | 0.000 | 4.303 | -4.303 | 4.303 |
| 80 | ARG | 81 | ASP | 0.000 | 4.296 | -4.296 | 4.296 |
| 120 | TYR | 241 | LEU | 0.000 | 4.261 | -4.261 | 4.261 |
| 120 | TYR | 284 | ASN | 4.260 | 0.000 | 4.260 | 4.260 |
| 240 | PHE | 295 | ASN | 0.000 | 4.165 | -4.165 | 4.165 |
| 248 | PHE | 282 | PHE | 4.121 | 0.000 | 4.121 | 4.121 |
| 58 | PHE | 112 | VAL | 5.677 | 1.605 | 4.072 | 4.072 |
| 255 | PHE | 279 | TRP | 4.070 | 0.000 | 4.070 | 4.070 |
| 105 | TYR | 275 | MET | 4.046 | 0.000 | 4.046 | 4.046 |
| 124 | PHE | 208 | VAL | 0.000 | 4.039 | -4.039 | 4.039 |
| 53 | ASN | 120 | TYR | 4.032 | 0.000 | 4.032 | 4.032 |
| 124 | PHE | 204 | VAL | 0.000 | 4.006 | -4.006 | 4.006 |
| 126 | LYS | 303 | ASP | 3.941 | 0.000 | 3.941 | 3.941 |
| 65 | VAL | 105 | TYR | 1.929 | 5.855 | -3.926 | 3.926 |
| 26 | TYR | 30 | LEU | 0.315 | 4.221 | -3.906 | 3.906 |
| 292 | TYR | 314 | TRP | 3.900 | 0.000 | 3.900 | 3.900 |
| 244 | LEU | 314 | TRP | 3.879 | 0.000 | 3.879 | 3.879 |
| 252 | TRP | 284 | ASN | 0.000 | 3.849 | -3.849 | 3.849 |
| 203 | GLU | 238 | LYS | 3.826 | 0.000 | 3.826 | 3.826 |
| 120 | TYR | 288 | ILE | 3.786 | 0.000 | 3.786 | 3.786 |
| 276 | ASN | 278 | PRO | 3.759 | 0.000 | 3.759 | 3.759 |
| 177 | TYR | 271 | ALA | 3.684 | 0.000 | 3.684 | 3.684 |
| 207 | LEU | 224 | PHE | 3.665 | 0.000 | 3.665 | 3.665 |
| 113 | PHE | 287 | LEU | 3.649 | 0.000 | 3.649 | 3.649 |
| 110 | TYR | 190 | VAL | 0.000 | 3.637 | -3.637 | 3.637 |
| 59 | CYS | 277 | ILE | 3.629 | 0.000 | 3.629 | 3.629 |
| 52 | GLN | 57 | TYR | 4.050 | 0.430 | 3.620 | 3.620 |
| 50 | THR | 318 | PHE | 0.000 | 3.606 | -3.606 | 3.606 |
| 76 | ILE | 98 | THR | 0.000 | 3.588 | -3.588 | 3.588 |
| 120 | TYR | 238 | LYS | 0.000 | 3.582 | -3.582 | 3.582 |
| 48 | LYS | 315 | LYS | 0.000 | 3.566 | -3.566 | 3.566 |
| 52 | GLN | 136 | LYS | 6.679 | 3.136 | 3.543 | 3.543 |
| 300 | ASN | 316 | CYS | 0.000 | 3.485 | -3.485 | 3.485 |
| 111 | PRO | 146 | ILE | 0.664 | 4.129 | -3.465 | 3.465 |
| 240 | PHE | 318 | PHE | 3.442 | 0.000 | 3.442 | 3.442 |
| 176 | PHE | 270 | PRO | 3.418 | 0.000 | 3.418 | 3.418 |
| 47 | ARG | 313 | ASN | 3.407 | 0.000 | 3.407 | 3.407 |
| 66 | ASP | 109 | HIS | 0.000 | 3.387 | -3.387 | 3.387 |
| 69 | LEU | 105 | TYR | 0.000 | 3.378 | -3.378 | 3.378 |
| 81 | ASP | 89 | PHE | 3.377 | 0.000 | 3.377 | 3.377 |
| 35 | LYS | 70 | LEU | 0.000 | 3.335 | -3.335 | 3.335 |
| 113 | PHE | 244 | LEU | 0.000 | 3.327 | -3.327 | 3.327 |
| 42 | THR | 278 | PRO | 3.319 | 0.000 | 3.319 | 3.319 |
| 35 | LYS | 272 | TYR | 3.315 | 0.000 | 3.315 | 3.315 |
| 103 | PHE | 178 | VAL | 0.000 | 3.314 | -3.314 | 3.314 |
| 106 | GLY | 179 | SER | 3.261 | 0.000 | 3.261 | 3.261 |
| 317 | CYS | 318 | PHE | 0.458 | 3.704 | -3.245 | 3.245 |
| 99 | GLN | 167 | GLN | 3.213 | 0.000 | 3.213 | 3.213 |
| 36 | ILE | 66 | ASP | 3.171 | 0.000 | 3.171 | 3.171 |
| 262 | ILE | 267 | VAL | 4.334 | 1.179 | 3.155 | 3.155 |
| 201 | TRP | 238 | LYS | 0.000 | 3.152 | -3.152 | 3.152 |
| 299 | LEU | 318 | PHE | 3.152 | 0.000 | 3.152 | 3.152 |
| 284 | ASN | 309 | ASP | 3.146 | 0.000 | 3.146 | 3.146 |
| 309 | ASP | 314 | TRP | 3.109 | 0.000 | 3.109 | 3.109 |
| 288 | ILE | 292 | TYR | 3.105 | 0.000 | 3.105 | 3.105 |
| 114 | LEU | 193 | LEU | 0.000 | 3.097 | -3.097 | 3.097 |
| 76 | ILE | 94 | ILE | 3.097 | 0.000 | 3.097 | 3.097 |
| 47 | ARG | 336 | MET | 3.088 | 0.000 | 3.088 | 3.088 |
| 186 | SER | 259 | GLN | 3.798 | 0.713 | 3.085 | 3.085 |
| 279 | TRP | 283 | VAL | 3.070 | 0.000 | 3.070 | 3.070 |
| 107 | PHE | 186 | SER | 0.000 | 3.039 | -3.039 | 3.039 |
| 58 | PHE | 139 | TYR | 0.000 | 2.996 | -2.996 | 2.996 |
| 211 | ILE | 223 | TYR | 2.978 | 0.000 | 2.978 | 2.978 |
| 248 | PHE | 286 | PHE | 2.967 | 0.000 | 2.967 | 2.967 |
| 105 | TYR | 272 | TYR | 2.967 | 0.000 | 2.967 | 2.967 |
| 64 | PHE | 147 | TRP | 0.000 | 2.966 | -2.966 | 2.966 |
| 289 | ALA | 314 | TRP | 2.940 | 0.000 | 2.940 | 2.940 |
| 45 | MET | 292 | TYR | 0.000 | 2.934 | -2.934 | 2.934 |
| 137 | LEU | 141 | PHE | 0.545 | 3.475 | -2.930 | 2.930 |
| 88 | ARG | 93 | HIS | 2.913 | 0.000 | 2.913 | 2.913 |
| 65 | VAL | 109 | HIS | 0.000 | 2.908 | -2.908 | 2.908 |
| 29 | PHE | 70 | LEU | 2.891 | 0.000 | 2.891 | 2.891 |
| 203 | GLU | 242 | SER | 2.886 | 0.000 | 2.886 | 2.886 |
| 35 | LYS | 275 | MET | 2.872 | 0.000 | 2.872 | 2.872 |
| 102 | SER | 177 | TYR | 2.860 | 0.000 | 2.860 | 2.860 |
| 106 | GLY | 252 | TRP | 0.000 | 2.823 | -2.823 | 2.823 |
| 62 | LEU | 105 | TYR | 2.808 | 0.000 | 2.808 | 2.808 |
| 54 | PHE | 132 | PHE | 0.000 | 2.803 | -2.803 | 2.803 |
| 216 | TYR | 217 | MET | 2.803 | 0.000 | 2.803 | 2.803 |
| 96 | LEU | 164 | LEU | 0.184 | 2.979 | -2.795 | 2.795 |
| 120 | TYR | 204 | VAL | 0.000 | 2.786 | -2.786 | 2.786 |
| 255 | PHE | 277 | ILE | 0.000 | 2.780 | -2.780 | 2.780 |
| 107 | PHE | 153 | TYR | 3.234 | 0.469 | 2.765 | 2.765 |
| 248 | PHE | 284 | ASN | 0.000 | 2.763 | -2.763 | 2.763 |
| 211 | ILE | 224 | PHE | 2.730 | 0.000 | 2.730 | 2.730 |
| 199 | THR | 238 | LYS | 2.728 | 0.000 | 2.728 | 2.728 |
| 106 | GLY | 181 | GLN | 2.723 | 0.000 | 2.723 | 2.723 |
| 196 | ALA | 245 | ILE | 2.719 | 0.000 | 2.719 | 2.719 |
| 84 | LEU | 89 | PHE | 2.683 | 0.000 | 2.683 | 2.683 |
| 50 | THR | 310 | PRO | 2.678 | 0.000 | 2.678 | 2.678 |
| 20 | GLN | 22 | LEU | 0.000 | 2.658 | -2.658 | 2.658 |
| 57 | TYR | 139 | TYR | 2.653 | 0.000 | 2.653 | 2.653 |
| 120 | TYR | 237 | LYS | 0.000 | 2.651 | -2.651 | 2.651 |
| 293 | TRP | 294 | PHE | 0.000 | 2.646 | -2.646 | 2.646 |
| 102 | SER | 271 | ALA | 2.623 | 0.000 | 2.623 | 2.623 |
| 17 | GLN | 172 | ARG | 2.600 | 0.000 | 2.600 | 2.600 |
| 62 | LEU | 113 | PHE | 0.000 | 2.599 | -2.599 | 2.599 |
| 46 | ARG | 56 | GLU | 4.190 | 1.616 | 2.574 | 2.574 |
| 87 | ILE | 90 | THR | 0.000 | 2.573 | -2.573 | 2.573 |
| 72 | ASN | 102 | SER | 0.000 | 2.524 | -2.524 | 2.524 |
| 35 | LYS | 105 | TYR | 2.524 | 0.000 | 2.524 | 2.524 |
| 285 | SER | 314 | TRP | 2.513 | 0.000 | 2.513 | 2.513 |
| 193 | LEU | 248 | PHE | 2.702 | 0.219 | 2.483 | 2.483 |
| 55 | MET | 284 | ASN | 2.481 | 0.000 | 2.481 | 2.481 |
| 130 | LEU | 134 | CYS | 2.494 | 0.063 | 2.431 | 2.431 |
| 54 | PHE | 116 | ALA | 2.423 | 0.000 | 2.423 | 2.423 |
| 99 | GLN | 175 | PRO | 4.313 | 1.943 | 2.370 | 2.370 |
| 288 | ILE | 309 | ASP | 2.368 | 0.000 | 2.368 | 2.368 |
| 248 | PHE | 285 | SER | 2.360 | 0.000 | 2.360 | 2.360 |
| 231 | SER | 233 | THR | 2.359 | 0.000 | 2.359 | 2.359 |
| 126 | LYS | 128 | THR | 0.000 | 2.359 | -2.359 | 2.359 |
| 187 | PHE | 260 | VAL | 0.000 | 2.332 | -2.332 | 2.332 |
| 105 | TYR | 271 | ALA | 2.321 | 0.000 | 2.321 | 2.321 |
| 301 | LEU | 318 | PHE | 2.316 | 0.000 | 2.316 | 2.316 |
| 35 | LYS | 286 | PHE | 0.000 | 2.309 | -2.309 | 2.309 |
| 288 | ILE | 314 | TRP | 2.309 | 0.000 | 2.309 | 2.309 |
| 53 | ASN | 139 | TYR | 2.307 | 0.000 | 2.307 | 2.307 |
| 108 | LEU | 275 | MET | 2.305 | 0.000 | 2.305 | 2.305 |
| 190 | VAL | 256 | VAL | 0.000 | 2.292 | -2.292 | 2.292 |
| 297 | HIS | 301 | LEU | 0.000 | 2.285 | -2.285 | 2.285 |
| 43 | LEU | 277 | ILE | 2.280 | 0.000 | 2.280 | 2.280 |
| 119 | ASP | 139 | TYR | 6.945 | 9.217 | -2.272 | 2.272 |
| 240 | PHE | 293 | TRP | 2.268 | 0.000 | 2.268 | 2.268 |
| 110 | TYR | 248 | PHE | 0.000 | 2.266 | -2.266 | 2.266 |
| 43 | LEU | 60 | ILE | 0.066 | 2.302 | -2.236 | 2.236 |
| 28 | LEU | 272 | TYR | 2.232 | 0.000 | 2.232 | 2.232 |
| 42 | THR | 277 | ILE | 2.204 | 0.000 | 2.204 | 2.204 |
| 75 | ILE | 82 | PHE | 2.190 | 0.000 | 2.190 | 2.190 |
| 54 | PHE | 136 | LYS | 0.000 | 2.185 | -2.185 | 2.185 |
| 178 | VAL | 269 | ILE | 2.158 | 0.000 | 2.158 | 2.158 |
| 205 | THR | 238 | LYS | 0.000 | 2.154 | -2.154 | 2.154 |
| 277 | ILE | 281 | TYR | 2.150 | 0.000 | 2.150 | 2.150 |
| 197 | PHE | 201 | TRP | 4.663 | 2.514 | 2.149 | 2.149 |
| 155 | LEU | 161 | TYR | 0.000 | 2.147 | -2.147 | 2.147 |
| 204 | VAL | 242 | SER | 2.142 | 0.000 | 2.142 | 2.142 |
| 226 | PHE | 239 | ILE | 2.132 | 0.000 | 2.132 | 2.132 |
| 240 | PHE | 244 | LEU | 2.795 | 0.677 | 2.118 | 2.118 |
| 258 | LEU | 277 | ILE | 0.000 | 2.109 | -2.109 | 2.109 |
| 288 | ILE | 307 | PRO | 2.105 | 0.000 | 2.105 | 2.105 |
| 251 | THR | 312 | VAL | 2.103 | 0.000 | 2.103 | 2.103 |
| 292 | TYR | 299 | LEU | 2.095 | 0.000 | 2.095 | 2.095 |
| 79 | PHE | 82 | PHE | 2.093 | 0.000 | 2.093 | 2.093 |
| 39 | ASN | 276 | ASN | 2.050 | 0.000 | 2.050 | 2.050 |
| 58 | PHE | 147 | TRP | 2.045 | 0.000 | 2.045 | 2.045 |
| 82 | PHE | 88 | ARG | 2.045 | 0.000 | 2.045 | 2.045 |
| 117 | CYS | 200 | CYS | 0.000 | 2.017 | -2.017 | 2.017 |
| 284 | ASN | 288 | ILE | 1.556 | 3.570 | -2.013 | 2.013 |
| 79 | PHE | 83 | VAL | 0.000 | 2.010 | -2.010 | 2.010 |
| 202 | GLU | 238 | LYS | 2.002 | 0.000 | 2.002 | 2.002 |
| 157 | ASP | 160 | ILE | 3.902 | 1.947 | 1.955 | 1.955 |
| 38 | LEU | 278 | PRO | 1.942 | 0.000 | 1.942 | 1.942 |
| 38 | LEU | 289 | ALA | 0.000 | 1.941 | -1.941 | 1.941 |
| 48 | LYS | 314 | TRP | 0.000 | 1.917 | -1.917 | 1.917 |
| 52 | GLN | 139 | TYR | 1.906 | 0.000 | 1.906 | 1.906 |
| 194 | PHE | 249 | LEU | 0.000 | 1.906 | -1.906 | 1.906 |
| 151 | LEU | 155 | LEU | 0.000 | 1.902 | -1.902 | 1.902 |
| 200 | CYS | 242 | SER | 1.899 | 0.000 | 1.899 | 1.899 |
| 203 | GLU | 239 | ILE | 1.892 | 0.000 | 1.892 | 1.892 |
| 124 | PHE | 291 | VAL | 1.885 | 0.000 | 1.885 | 1.885 |
| 61 | SER | 147 | TRP | 3.515 | 1.641 | 1.874 | 1.874 |
| 192 | ILE | 286 | PHE | 1.872 | 0.000 | 1.872 | 1.872 |
| 306 | LEU | 318 | PHE | 1.871 | 0.000 | 1.871 | 1.871 |
| 167 | GLN | 175 | PRO | 3.799 | 5.666 | -1.868 | 1.868 |
| 54 | PHE | 112 | VAL | 1.844 | 0.000 | 1.844 | 1.844 |
| 124 | PHE | 299 | LEU | 1.838 | 0.000 | 1.838 | 1.838 |
| 103 | PHE | 160 | ILE | 1.950 | 0.112 | 1.838 | 1.838 |
| 62 | LEU | 112 | VAL | 0.000 | 1.833 | -1.833 | 1.833 |
| 178 | VAL | 182 | SER | 0.000 | 1.830 | -1.830 | 1.830 |
| 185 | LEU | 279 | TRP | 1.829 | 0.000 | 1.829 | 1.829 |
| 58 | PHE | 119 | ASP | 0.000 | 1.815 | -1.815 | 1.815 |
| 113 | PHE | 288 | ILE | 0.000 | 1.815 | -1.815 | 1.815 |
| 28 | LEU | 98 | THR | 1.812 | 0.000 | 1.812 | 1.812 |
| 53 | ASN | 119 | ASP | 1.802 | 0.000 | 1.802 | 1.802 |
| 187 | PHE | 256 | VAL | 0.000 | 1.802 | -1.802 | 1.802 |
| 247 | CYS | 284 | ASN | 0.000 | 1.795 | -1.795 | 1.795 |
| 270 | PRO | 272 | TYR | 5.322 | 3.585 | 1.737 | 1.737 |
| 59 | CYS | 280 | LEU | 1.730 | 0.000 | 1.730 | 1.730 |
| 92 | TYR | 96 | LEU | 1.960 | 0.240 | 1.720 | 1.720 |
| 55 | MET | 116 | ALA | 1.730 | 0.027 | 1.703 | 1.703 |
| 32 | ILE | 70 | LEU | 1.699 | 0.018 | 1.681 | 1.681 |
| 65 | VAL | 147 | TRP | 3.931 | 2.257 | 1.675 | 1.675 |
| 248 | PHE | 314 | TRP | 1.673 | 0.000 | 1.673 | 1.673 |
| 153 | TYR | 157 | ASP | 1.715 | 0.045 | 1.670 | 1.670 |
| 110 | TYR | 186 | SER | 0.000 | 1.666 | -1.666 | 1.666 |
| 98 | THR | 272 | TYR | 1.644 | 0.000 | 1.644 | 1.644 |
| 58 | PHE | 280 | LEU | 1.643 | 0.000 | 1.643 | 1.643 |
| 58 | PHE | 143 | VAL | 1.725 | 0.085 | 1.640 | 1.640 |
| 295 | ASN | 298 | LYS | 1.640 | 0.000 | 1.640 | 1.640 |
| 210 | ALA | 223 | TYR | 1.632 | 0.000 | 1.632 | 1.632 |
| 101 | ILE | 105 | TYR | 4.677 | 3.046 | 1.631 | 1.631 |
| 126 | LYS | 304 | ILE | 1.618 | 0.000 | 1.618 | 1.618 |
| 292 | TYR | 318 | PHE | 1.616 | 0.000 | 1.616 | 1.616 |
| 252 | TRP | 278 | PRO | 1.606 | 0.000 | 1.606 | 1.606 |
| 87 | ILE | 89 | PHE | 1.616 | 0.011 | 1.606 | 1.606 |
| 29 | PHE | 74 | SER | 1.596 | 0.000 | 1.596 | 1.596 |
| 207 | LEU | 246 | VAL | 1.591 | 0.000 | 1.591 | 1.591 |
| 157 | ASP | 179 | SER | 0.000 | 1.569 | -1.569 | 1.569 |
| 309 | ASP | 310 | PRO | 2.778 | 1.217 | 1.561 | 1.561 |
| 107 | PHE | 150 | VAL | 0.756 | 2.315 | -1.559 | 1.559 |
| 212 | ARG | 216 | TYR | 0.000 | 1.557 | -1.557 | 1.557 |
| 54 | PHE | 139 | TYR | 4.807 | 6.364 | -1.557 | 1.557 |
| 39 | ASN | 66 | ASP | 1.891 | 3.442 | -1.551 | 1.551 |
| 279 | TRP | 280 | LEU | 1.546 | 0.000 | 1.546 | 1.546 |
| 76 | ILE | 90 | THR | 1.535 | 0.000 | 1.535 | 1.535 |
| 298 | LYS | 304 | ILE | 1.533 | 0.000 | 1.533 | 1.533 |
| 240 | PHE | 317 | CYS | 1.533 | 0.000 | 1.533 | 1.533 |
| 159 | ALA | 179 | SER | 0.000 | 1.528 | -1.528 | 1.528 |
| 244 | LEU | 293 | TRP | 1.527 | 0.000 | 1.527 | 1.527 |
| 285 | SER | 312 | VAL | 1.527 | 0.000 | 1.527 | 1.527 |
| 54 | PHE | 119 | ASP | 4.061 | 2.539 | 1.522 | 1.522 |
| 240 | PHE | 291 | VAL | 0.000 | 1.520 | -1.520 | 1.520 |
| 95 | CYS | 174 | CYS | 5.967 | 4.452 | 1.515 | 1.515 |
| 76 | ILE | 82 | PHE | 1.508 | 0.000 | 1.508 | 1.508 |
| 244 | LEU | 317 | CYS | 1.503 | 0.000 | 1.503 | 1.503 |
| 119 | ASP | 123 | ASN | 3.510 | 4.999 | -1.489 | 1.489 |
| 252 | TRP | 312 | VAL | 1.483 | 0.000 | 1.483 | 1.483 |
| 31 | ILE | 273 | ILE | 1.469 | 0.000 | 1.469 | 1.469 |
| 247 | CYS | 312 | VAL | 1.467 | 0.000 | 1.467 | 1.467 |
| 31 | ILE | 35 | LYS | 0.000 | 1.466 | -1.466 | 1.466 |
| 123 | ASN | 139 | TYR | 1.465 | 0.000 | 1.465 | 1.465 |
| 269 | ILE | 273 | ILE | 0.546 | 2.006 | -1.460 | 1.460 |
| 51 | CYS | 308 | LEU | 1.451 | 0.000 | 1.451 | 1.451 |
| 54 | PHE | 143 | VAL | 1.446 | 0.000 | 1.446 | 1.446 |
| 240 | PHE | 296 | CYS | 1.445 | 0.000 | 1.445 | 1.445 |
| 100 | ILE | 154 | VAL | 0.523 | 1.967 | -1.445 | 1.445 |
| 193 | LEU | 286 | PHE | 1.443 | 0.000 | 1.443 | 1.443 |
| 319 | ILE | 321 | LEU | 1.439 | 0.000 | 1.439 | 1.439 |
| 82 | PHE | 84 | LEU | 1.434 | 0.000 | 1.434 | 1.434 |
| 42 | THR | 311 | PHE | 1.433 | 0.000 | 1.433 | 1.433 |
| 177 | TYR | 270 | PRO | 1.431 | 0.000 | 1.431 | 1.431 |
| 187 | PHE | 191 | MET | 3.150 | 4.572 | -1.422 | 1.422 |
| 104 | THR | 151 | LEU | 2.056 | 0.636 | 1.420 | 1.420 |
| 187 | PHE | 263 | VAL | 1.403 | 0.000 | 1.403 | 1.403 |
| 281 | TYR | 310 | PRO | 1.394 | 0.000 | 1.394 | 1.394 |
| 299 | LEU | 304 | ILE | 1.392 | 0.000 | 1.392 | 1.392 |
| 120 | TYR | 287 | LEU | 1.391 | 0.000 | 1.391 | 1.391 |
| 176 | PHE | 178 | VAL | 1.390 | 0.000 | 1.390 | 1.390 |
| 84 | LEU | 85 | LEU | 1.380 | 0.000 | 1.380 | 1.380 |
| 33 | LEU | 70 | LEU | 1.379 | 0.000 | 1.379 | 1.379 |
| 179 | SER | 274 | GLU | 1.371 | 0.000 | 1.371 | 1.371 |
| 69 | LEU | 101 | ILE | 1.368 | 0.000 | 1.368 | 1.368 |
| 125 | SER | 127 | THR | 1.362 | 0.000 | 1.362 | 1.362 |
| 49 | ASN | 308 | LEU | 1.355 | 0.000 | 1.355 | 1.355 |
| 55 | MET | 112 | VAL | 1.352 | 0.000 | 1.352 | 1.352 |
| 72 | ASN | 97 | PHE | 1.342 | 0.000 | 1.342 | 1.342 |
| 62 | LEU | 109 | HIS | 0.000 | 1.336 | -1.336 | 1.336 |
| 104 | THR | 154 | VAL | 2.064 | 3.396 | -1.331 | 1.331 |
| 25 | ASN | 94 | ILE | 1.318 | 0.000 | 1.318 | 1.318 |
| 77 | LEU | 94 | ILE | 1.317 | 0.000 | 1.317 | 1.317 |
| 62 | LEU | 275 | MET | 1.309 | 0.000 | 1.309 | 1.309 |
| 54 | PHE | 146 | ILE | 1.305 | 0.000 | 1.305 | 1.305 |
| 69 | LEU | 97 | PHE | 1.304 | 0.000 | 1.304 | 1.304 |
| 28 | LEU | 77 | LEU | 0.000 | 1.296 | -1.296 | 1.296 |
| 43 | LEU | 281 | TYR | 1.277 | 0.000 | 1.277 | 1.277 |
| 154 | VAL | 160 | ILE | 2.958 | 1.687 | 1.271 | 1.271 |
| 72 | ASN | 76 | ILE | 0.000 | 1.266 | -1.266 | 1.266 |
| 247 | CYS | 317 | CYS | 1.266 | 0.000 | 1.266 | 1.266 |
| 200 | CYS | 245 | ILE | 1.261 | 0.000 | 1.261 | 1.261 |
| 124 | PHE | 234 | VAL | 0.000 | 1.257 | -1.257 | 1.257 |
| 32 | ILE | 74 | SER | 0.000 | 1.254 | -1.254 | 1.254 |
| 46 | ARG | 310 | PRO | 1.254 | 0.000 | 1.254 | 1.254 |
| 102 | SER | 176 | PHE | 0.000 | 1.252 | -1.252 | 1.252 |
| 62 | LEU | 147 | TRP | 1.241 | 0.000 | 1.241 | 1.241 |
| 58 | PHE | 275 | MET | 1.228 | 0.000 | 1.228 | 1.228 |
| 90 | THR | 93 | HIS | 1.222 | 0.000 | 1.222 | 1.222 |
| 88 | ARG | 90 | THR | 1.214 | 0.000 | 1.214 | 1.214 |
| 243 | LYS | 295 | ASN | 0.000 | 1.188 | -1.188 | 1.188 |
| 185 | LEU | 189 | MET | 0.152 | 1.335 | -1.183 | 1.183 |
| 251 | THR | 311 | PHE | 1.183 | 0.000 | 1.183 | 1.183 |
| 105 | TYR | 147 | TRP | 1.873 | 0.704 | 1.169 | 1.169 |
| 103 | PHE | 163 | SER | 1.167 | 0.000 | 1.167 | 1.167 |
| 80 | ARG | 90 | THR | 1.167 | 0.000 | 1.167 | 1.167 |
| 120 | TYR | 291 | VAL | 1.166 | 0.000 | 1.166 | 1.166 |
| 120 | TYR | 307 | PRO | 1.165 | 0.000 | 1.165 | 1.165 |
| 251 | THR | 280 | LEU | 0.000 | 1.155 | -1.155 | 1.155 |
| 62 | LEU | 276 | ASN | 1.148 | 0.000 | 1.148 | 1.148 |
| 77 | LEU | 80 | ARG | 0.000 | 1.147 | -1.147 | 1.147 |
| 65 | VAL | 108 | LEU | 0.000 | 1.143 | -1.143 | 1.143 |
| 178 | VAL | 268 | GLN | 1.142 | 0.000 | 1.142 | 1.142 |
| 76 | ILE | 93 | HIS | 1.139 | 0.000 | 1.139 | 1.139 |
| 313 | ASN | 315 | LYS | 1.133 | 0.000 | 1.133 | 1.133 |
| 50 | THR | 308 | LEU | 1.132 | 0.000 | 1.132 | 1.132 |
| 200 | CYS | 204 | VAL | 1.211 | 0.082 | 1.129 | 1.129 |
| 46 | ARG | 60 | ILE | 0.166 | 1.291 | -1.125 | 1.125 |
| 113 | PHE | 283 | VAL | 1.110 | 0.000 | 1.110 | 1.110 |
| 42 | THR | 292 | TYR | 0.000 | 1.107 | -1.107 | 1.107 |
| 124 | PHE | 211 | ILE | 0.000 | 1.096 | -1.096 | 1.096 |
| 256 | VAL | 282 | PHE | 1.096 | 0.000 | 1.096 | 1.096 |
| 18 | THR | 19 | ASN | 1.095 | 0.000 | 1.095 | 1.095 |
| 213 | ILE | 221 | ILE | 1.093 | 0.000 | 1.093 | 1.093 |
| 117 | CYS | 287 | LEU | 1.090 | 0.000 | 1.090 | 1.090 |
| 258 | LEU | 262 | ILE | 1.253 | 0.163 | 1.089 | 1.089 |
| 194 | PHE | 198 | ILE | 2.488 | 3.567 | -1.079 | 1.079 |
| 81 | ASP | 90 | THR | 1.077 | 0.000 | 1.077 | 1.077 |
| 73 | ILE | 94 | ILE | 1.071 | 0.000 | 1.071 | 1.071 |
| 42 | THR | 63 | ALA | 0.000 | 1.069 | -1.069 | 1.069 |
| 35 | LYS | 39 | ASN | 1.068 | 0.000 | 1.068 | 1.068 |
| 200 | CYS | 238 | LYS | 1.065 | 0.000 | 1.065 | 1.065 |
| 258 | LEU | 269 | ILE | 0.000 | 1.061 | -1.061 | 1.061 |
| 251 | THR | 252 | TRP | 2.585 | 1.526 | 1.059 | 1.059 |
| 239 | ILE | 243 | LYS | 0.112 | 1.169 | -1.058 | 1.058 |
| 244 | LEU | 289 | ALA | 1.052 | 0.000 | 1.052 | 1.052 |
| 252 | TRP | 311 | PHE | 1.049 | 0.000 | 1.049 | 1.049 |
| 125 | SER | 207 | LEU | 0.000 | 1.048 | -1.048 | 1.048 |
| 117 | CYS | 245 | ILE | 0.000 | 1.032 | -1.032 | 1.032 |
| 89 | PHE | 97 | PHE | 1.029 | 0.000 | 1.029 | 1.029 |
| 76 | ILE | 97 | PHE | 1.023 | 0.000 | 1.023 | 1.023 |
| 126 | LYS | 130 | LEU | 0.000 | 1.020 | -1.020 | 1.020 |
| 58 | PHE | 108 | LEU | 1.019 | 0.000 | 1.019 | 1.019 |
| 58 | PHE | 61 | SER | 1.017 | 0.000 | 1.017 | 1.017 |
| 276 | ASN | 279 | TRP | 1.328 | 0.316 | 1.012 | 1.012 |
| 212 | ARG | 221 | ILE | 1.012 | 0.000 | 1.012 | 1.012 |
| 56 | GLU | 60 | ILE | 0.352 | 1.361 | -1.009 | 1.009 |
| 61 | SER | 112 | VAL | 0.000 | 1.009 | -1.009 | 1.009 |
| 35 | LYS | 276 | ASN | 1.007 | 0.000 | 1.007 | 1.007 |
| 104 | THR | 147 | TRP | 1.001 | 0.000 | 1.001 | 1.001 |
| 240 | PHE | 299 | LEU | 0.996 | 0.000 | 0.996 | 0.996 |
| 167 | GLN | 177 | TYR | 0.000 | 0.992 | -0.992 | 0.992 |
| 90 | THR | 92 | TYR | 0.985 | 0.000 | 0.985 | 0.985 |
| 252 | TRP | 255 | PHE | 0.977 | 0.000 | 0.977 | 0.977 |
| 214 | THR | 220 | THR | 0.975 | 0.000 | 0.975 | 0.975 |
| 237 | LYS | 296 | CYS | 0.970 | 0.000 | 0.970 | 0.970 |
| 304 | ILE | 319 | ILE | 0.000 | 0.966 | -0.966 | 0.966 |
| 57 | TYR | 143 | VAL | 0.963 | 0.000 | 0.963 | 0.963 |
| 274 | GLU | 279 | TRP | 0.955 | 0.000 | 0.955 | 0.955 |
| 29 | PHE | 77 | LEU | 0.952 | 0.000 | 0.952 | 0.952 |
| 22 | LEU | 91 | LYS | 0.947 | 0.000 | 0.947 | 0.947 |
| 179 | SER | 271 | ALA | 0.943 | 0.000 | 0.943 | 0.943 |
| 230 | SER | 231 | SER | 0.938 | 0.000 | 0.938 | 0.938 |
| 211 | ILE | 222 | LEU | 0.932 | 0.000 | 0.932 | 0.932 |
| 59 | CYS | 281 | TYR | 0.926 | 0.000 | 0.926 | 0.926 |
| 259 | GLN | 279 | TRP | 0.926 | 0.000 | 0.926 | 0.926 |
| 54 | PHE | 142 | THR | 0.923 | 0.000 | 0.923 | 0.923 |
| 114 | LEU | 196 | ALA | 0.000 | 0.919 | -0.919 | 0.919 |
| 109 | HIS | 185 | LEU | 0.915 | 0.000 | 0.915 | 0.915 |
| 212 | ARG | 222 | LEU | 0.911 | 0.000 | 0.911 | 0.911 |
| 114 | LEU | 118 | ILE | 0.626 | 1.533 | -0.907 | 0.907 |
| 270 | PRO | 273 | ILE | 1.555 | 0.649 | 0.906 | 0.906 |
| 190 | VAL | 260 | VAL | 0.906 | 0.000 | 0.906 | 0.906 |
| 55 | MET | 120 | TYR | 0.904 | 0.000 | 0.904 | 0.904 |
| 39 | ASN | 67 | LEU | 0.000 | 0.896 | -0.896 | 0.896 |
| 124 | PHE | 304 | ILE | 0.892 | 0.000 | 0.892 | 0.892 |
| 244 | LEU | 292 | TYR | 0.892 | 0.000 | 0.892 | 0.892 |
| 116 | ALA | 287 | LEU | 0.887 | 0.000 | 0.887 | 0.887 |
| 43 | LEU | 64 | PHE | 0.000 | 0.872 | -0.872 | 0.872 |
| 80 | ARG | 91 | LYS | 0.867 | 0.000 | 0.867 | 0.867 |
| 304 | ILE | 306 | LEU | 0.984 | 1.850 | -0.866 | 0.866 |
| 262 | ILE | 269 | ILE | 1.861 | 2.722 | -0.861 | 0.861 |
| 32 | ILE | 73 | ILE | 0.944 | 0.084 | 0.859 | 0.859 |
| 286 | PHE | 290 | THR | 2.441 | 3.300 | -0.859 | 0.859 |
| 39 | ASN | 70 | LEU | 0.000 | 0.857 | -0.857 | 0.857 |
| 121 | CYS | 204 | VAL | 0.000 | 0.855 | -0.855 | 0.855 |
| 124 | PHE | 292 | TYR | 0.848 | 0.000 | 0.848 | 0.848 |
| 216 | TYR | 221 | ILE | 0.847 | 0.000 | 0.847 | 0.847 |
| 204 | VAL | 246 | VAL | 0.846 | 0.000 | 0.846 | 0.846 |
| 269 | ILE | 274 | GLU | 1.407 | 2.251 | -0.845 | 0.845 |
| 207 | LEU | 211 | ILE | 0.000 | 0.836 | -0.836 | 0.836 |
| 103 | PHE | 154 | VAL | 2.037 | 1.201 | 0.836 | 0.836 |
| 83 | VAL | 88 | ARG | 0.829 | 0.000 | 0.829 | 0.829 |
| 320 | PRO | 322 | THR | 0.000 | 0.828 | -0.828 | 0.828 |
| 273 | ILE | 277 | ILE | 0.000 | 0.824 | -0.824 | 0.824 |
| 236 | SER | 299 | LEU | 0.000 | 0.817 | -0.817 | 0.817 |
| 55 | MET | 280 | LEU | 0.815 | 0.000 | 0.815 | 0.815 |
| 184 | TRP | 264 | LEU | 0.000 | 0.814 | -0.814 | 0.814 |
| 96 | LEU | 100 | ILE | 0.877 | 1.691 | -0.814 | 0.814 |
| 106 | GLY | 182 | SER | 0.812 | 0.000 | 0.812 | 0.812 |
| 32 | ILE | 77 | LEU | 0.000 | 0.809 | -0.809 | 0.809 |
| 38 | LEU | 290 | THR | 0.000 | 0.809 | -0.809 | 0.809 |
| 68 | LEU | 147 | TRP | 0.000 | 0.803 | -0.803 | 0.803 |
| 214 | THR | 219 | GLU | 0.802 | 0.000 | 0.802 | 0.802 |
| 301 | LEU | 320 | PRO | 0.800 | 0.000 | 0.800 | 0.800 |
| 45 | MET | 311 | PHE | 0.797 | 0.000 | 0.797 | 0.797 |
| 78 | TYR | 82 | PHE | 0.000 | 0.794 | -0.794 | 0.794 |
| 238 | LYS | 293 | TRP | 0.786 | 0.000 | 0.786 | 0.786 |
| 272 | TYR | 273 | ILE | 4.916 | 5.701 | -0.785 | 0.785 |
| 179 | SER | 182 | SER | 3.447 | 2.662 | 0.785 | 0.785 |
| 76 | ILE | 91 | LYS | 0.784 | 0.000 | 0.784 | 0.784 |
| 11 | PHE | 12 | GLN | 0.000 | 0.779 | -0.779 | 0.779 |
| 284 | ASN | 310 | PRO | 0.774 | 0.000 | 0.774 | 0.774 |
| 62 | LEU | 66 | ASP | 0.768 | 0.000 | 0.768 | 0.768 |
| 62 | LEU | 280 | LEU | 0.758 | 0.000 | 0.758 | 0.758 |
| 309 | ASP | 311 | PHE | 0.747 | 0.000 | 0.747 | 0.747 |
| 186 | SER | 263 | VAL | 0.746 | 0.000 | 0.746 | 0.746 |
| 32 | ILE | 69 | LEU | 0.745 | 0.000 | 0.745 | 0.745 |
| 265 | LEU | 267 | VAL | 0.648 | 1.386 | -0.738 | 0.738 |
| 82 | PHE | 87 | ILE | 0.732 | 0.000 | 0.732 | 0.732 |
| 107 | PHE | 160 | ILE | 0.722 | 0.000 | 0.722 | 0.722 |
| 299 | LEU | 306 | LEU | 0.721 | 0.000 | 0.721 | 0.721 |
| 183 | TYR | 274 | GLU | 0.716 | 0.000 | 0.716 | 0.716 |
| 190 | VAL | 259 | GLN | 0.713 | 0.000 | 0.713 | 0.713 |
| 50 | THR | 309 | ASP | 0.711 | 0.000 | 0.711 | 0.711 |
| 38 | LEU | 286 | PHE | 0.000 | 0.707 | -0.707 | 0.707 |
| 108 | LEU | 146 | ILE | 0.986 | 0.285 | 0.701 | 0.701 |
| 55 | MET | 240 | PHE | 0.000 | 0.685 | -0.685 | 0.685 |
| 25 | ASN | 77 | LEU | 0.682 | 0.000 | 0.682 | 0.682 |
| 45 | MET | 56 | GLU | 0.000 | 0.677 | -0.677 | 0.677 |
| 80 | ARG | 89 | PHE | 0.664 | 0.000 | 0.664 | 0.664 |
| 313 | ASN | 316 | CYS | 0.744 | 1.408 | -0.664 | 0.664 |
| 39 | ASN | 278 | PRO | 0.663 | 0.000 | 0.663 | 0.663 |
| 157 | ASP | 159 | ALA | 1.195 | 1.858 | -0.663 | 0.663 |
| 247 | CYS | 314 | TRP | 0.655 | 0.000 | 0.655 | 0.655 |
| 65 | VAL | 101 | ILE | 0.654 | 0.000 | 0.654 | 0.654 |
| 28 | LEU | 94 | ILE | 0.647 | 0.000 | 0.647 | 0.647 |
| 220 | THR | 221 | ILE | 0.000 | 0.644 | -0.644 | 0.644 |
| 107 | PHE | 110 | TYR | 0.000 | 0.643 | -0.643 | 0.643 |
| 109 | HIS | 252 | TRP | 0.000 | 0.641 | -0.641 | 0.641 |
| 243 | LYS | 291 | VAL | 0.000 | 0.633 | -0.633 | 0.633 |
| 54 | PHE | 58 | PHE | 0.674 | 0.041 | 0.633 | 0.633 |
| 35 | LYS | 283 | VAL | 0.000 | 0.632 | -0.632 | 0.632 |
| 306 | LEU | 307 | PRO | 0.737 | 1.368 | -0.631 | 0.631 |
| 52 | GLN | 56 | GLU | 0.630 | 0.000 | 0.630 | 0.630 |
| 115 | THR | 142 | THR | 0.618 | 1.244 | -0.625 | 0.625 |
| 247 | CYS | 291 | VAL | 0.000 | 0.612 | -0.612 | 0.612 |
| 224 | PHE | 225 | PRO | 0.255 | 0.866 | -0.611 | 0.611 |
| 70 | LEU | 282 | PHE | 0.000 | 0.608 | -0.608 | 0.608 |
| 57 | TYR | 136 | LYS | 4.446 | 5.047 | -0.601 | 0.601 |
| 99 | GLN | 176 | PHE | 0.000 | 0.598 | -0.598 | 0.598 |
| 109 | HIS | 113 | PHE | 0.000 | 0.598 | -0.598 | 0.598 |
| 249 | LEU | 254 | PRO | 0.000 | 0.586 | -0.586 | 0.586 |
| 7 | GLU | 8 | ASN | 0.000 | 0.586 | -0.586 | 0.586 |
| 222 | LEU | 224 | PHE | 0.219 | 0.803 | -0.584 | 0.584 |
| 123 | ASN | 135 | GLN | 1.282 | 0.699 | 0.582 | 0.582 |
| 259 | GLN | 262 | ILE | 0.581 | 0.000 | 0.581 | 0.581 |
| 36 | ILE | 70 | LEU | 1.920 | 1.341 | 0.579 | 0.579 |
| 53 | ASN | 308 | LEU | 0.579 | 0.000 | 0.579 | 0.579 |
| 307 | PRO | 313 | ASN | 0.000 | 0.577 | -0.577 | 0.577 |
| 275 | MET | 280 | LEU | 0.576 | 0.000 | 0.576 | 0.576 |
| 153 | TYR | 182 | SER | 0.000 | 0.576 | -0.576 | 0.576 |
| 31 | ILE | 272 | TYR | 0.570 | 0.000 | 0.570 | 0.570 |
| 249 | LEU | 256 | VAL | 0.568 | 0.000 | 0.568 | 0.568 |
| 184 | TRP | 188 | PHE | 1.154 | 0.594 | 0.561 | 0.561 |
| 62 | LEU | 277 | ILE | 0.556 | 0.000 | 0.556 | 0.556 |
| 35 | LYS | 273 | ILE | 0.555 | 0.000 | 0.555 | 0.555 |
| 122 | LEU | 126 | LYS | 0.000 | 0.554 | -0.554 | 0.554 |
| 253 | LEU | 257 | LEU | 1.003 | 1.557 | -0.554 | 0.554 |
| 131 | SER | 134 | CYS | 0.221 | 0.774 | -0.553 | 0.553 |
| 43 | LEU | 67 | LEU | 0.000 | 0.542 | -0.542 | 0.542 |
| 193 | LEU | 282 | PHE | 0.541 | 0.000 | 0.541 | 0.541 |
| 207 | LEU | 243 | LYS | 0.541 | 0.000 | 0.541 | 0.541 |
| 323 | ILE | 326 | LEU | 0.000 | 0.540 | -0.540 | 0.540 |
| 39 | ASN | 285 | SER | 0.000 | 0.537 | -0.537 | 0.537 |
| 255 | PHE | 278 | PRO | 0.537 | 0.000 | 0.537 | 0.537 |
| 61 | SER | 143 | VAL | 1.659 | 1.123 | 0.536 | 0.536 |
| 43 | LEU | 63 | ALA | 0.432 | 0.963 | -0.532 | 0.532 |
| 157 | ASP | 182 | SER | 0.000 | 0.530 | -0.530 | 0.530 |
| 184 | TRP | 187 | PHE | 0.796 | 0.267 | 0.529 | 0.529 |
| 63 | ALA | 277 | ILE | 0.525 | 0.000 | 0.525 | 0.525 |
| 310 | PRO | 311 | PHE | 1.038 | 0.514 | 0.524 | 0.524 |
| 224 | PHE | 246 | VAL | 0.523 | 0.000 | 0.523 | 0.523 |
| 75 | ILE | 79 | PHE | 1.053 | 1.575 | -0.522 | 0.522 |
| 153 | TYR | 160 | ILE | 0.520 | 0.000 | 0.520 | 0.520 |
| 196 | ALA | 241 | LEU | 0.515 | 0.000 | 0.515 | 0.515 |
| 51 | CYS | 53 | ASN | 0.284 | 0.797 | -0.513 | 0.513 |
| 239 | ILE | 242 | SER | 0.511 | 0.000 | 0.511 | 0.511 |
| 106 | GLY | 271 | ALA | 0.507 | 0.000 | 0.507 | 0.507 |
| 244 | LEU | 291 | VAL | 0.000 | 0.507 | -0.507 | 0.507 |
| 107 | PHE | 182 | SER | 0.000 | 0.505 | -0.505 | 0.505 |
| 233 | THR | 235 | ARG | 0.492 | 0.000 | 0.492 | 0.492 |
| 92 | TYR | 165 | LYS | 0.000 | 0.492 | -0.492 | 0.492 |
| 99 | GLN | 177 | TYR | 0.000 | 0.488 | -0.488 | 0.488 |
| 228 | SER | 322 | THR | 0.486 | 0.000 | 0.486 | 0.486 |
| 208 | VAL | 211 | ILE | 0.480 | 0.000 | 0.480 | 0.480 |
| 124 | PHE | 298 | LYS | 0.476 | 0.000 | 0.476 | 0.476 |
| 96 | LEU | 161 | TYR | 0.000 | 0.467 | -0.467 | 0.467 |
| 55 | MET | 283 | VAL | 0.460 | 0.000 | 0.460 | 0.460 |
| 99 | GLN | 164 | LEU | 2.183 | 2.642 | -0.459 | 0.459 |
| 28 | LEU | 32 | ILE | 1.284 | 1.742 | -0.458 | 0.458 |
| 109 | HIS | 248 | PHE | 0.000 | 0.454 | -0.454 | 0.454 |
| 107 | PHE | 154 | VAL | 0.684 | 0.230 | 0.454 | 0.454 |
| 250 | SER | 251 | THR | 0.751 | 0.297 | 0.453 | 0.453 |
| 43 | LEU | 59 | CYS | 0.453 | 0.000 | 0.453 | 0.453 |
| 291 | VAL | 295 | ASN | 0.598 | 1.046 | -0.447 | 0.447 |
| 314 | TRP | 317 | CYS | 0.446 | 0.000 | 0.446 | 0.446 |
| 110 | TYR | 256 | VAL | 0.000 | 0.445 | -0.445 | 0.445 |
| 333 | ILE | 335 | ILE | 0.000 | 0.445 | -0.445 | 0.445 |
| 248 | PHE | 256 | VAL | 0.444 | 0.000 | 0.444 | 0.444 |
| 199 | THR | 241 | LEU | 0.442 | 0.000 | 0.442 | 0.442 |
| 163 | SER | 167 | GLN | 0.441 | 0.000 | 0.441 | 0.441 |
| 122 | LEU | 127 | THR | 0.440 | 0.000 | 0.440 | 0.440 |
| 112 | VAL | 280 | LEU | 0.437 | 0.000 | 0.437 | 0.437 |
| 267 | VAL | 269 | ILE | 0.436 | 0.000 | 0.436 | 0.436 |
| 232 | TYR | 300 | ASN | 0.429 | 0.000 | 0.429 | 0.429 |
| 52 | GLN | 135 | GLN | 0.429 | 0.000 | 0.429 | 0.429 |
| 300 | ASN | 318 | PHE | 0.000 | 0.429 | -0.429 | 0.429 |
| 203 | GLU | 206 | THR | 0.424 | 0.000 | 0.424 | 0.424 |
| 40 | ILE | 67 | LEU | 0.000 | 0.423 | -0.423 | 0.423 |
| 73 | ILE | 98 | THR | 0.419 | 0.000 | 0.419 | 0.419 |
| 219 | GLU | 337 | ILE | 0.411 | 0.000 | 0.411 | 0.411 |
| 255 | PHE | 258 | LEU | 0.410 | 0.000 | 0.410 | 0.410 |
| 189 | MET | 283 | VAL | 0.409 | 0.000 | 0.409 | 0.409 |
| 251 | THR | 287 | LEU | 0.000 | 0.405 | -0.405 | 0.405 |
| 335 | ILE | 337 | ILE | 0.000 | 0.397 | -0.397 | 0.397 |
| 54 | PHE | 123 | ASN | 0.000 | 0.394 | -0.394 | 0.394 |
| 247 | CYS | 287 | LEU | 0.000 | 0.394 | -0.394 | 0.394 |
| 180 | ILE | 263 | VAL | 0.000 | 0.389 | -0.389 | 0.389 |
| 176 | PHE | 272 | TYR | 0.387 | 0.000 | 0.387 | 0.387 |
| 197 | PHE | 204 | VAL | 0.387 | 0.000 | 0.387 | 0.387 |
| 103 | PHE | 164 | LEU | 0.386 | 0.000 | 0.386 | 0.386 |
| 301 | LEU | 308 | LEU | 0.000 | 0.386 | -0.386 | 0.386 |
| 25 | ASN | 81 | ASP | 0.000 | 0.382 | -0.382 | 0.382 |
| 193 | LEU | 256 | VAL | 0.380 | 0.000 | 0.380 | 0.380 |
| 112 | VAL | 146 | ILE | 0.169 | 0.549 | -0.380 | 0.380 |
| 177 | TYR | 179 | SER | 0.482 | 0.107 | 0.376 | 0.376 |
| 69 | LEU | 98 | THR | 0.376 | 0.000 | 0.376 | 0.376 |
| 313 | ASN | 337 | ILE | 0.375 | 0.000 | 0.375 | 0.375 |
| 96 | LEU | 160 | ILE | 0.000 | 0.375 | -0.375 | 0.375 |
| 39 | ASN | 289 | ALA | 0.000 | 0.372 | -0.372 | 0.372 |
| 47 | ARG | 337 | ILE | 0.370 | 0.000 | 0.370 | 0.370 |
| 232 | TYR | 302 | LYS | 0.000 | 0.369 | -0.369 | 0.369 |
| 255 | PHE | 256 | VAL | 0.000 | 0.366 | -0.366 | 0.366 |
| 160 | ILE | 163 | SER | 0.364 | 0.000 | 0.364 | 0.364 |
| 244 | LEU | 288 | ILE | 0.000 | 0.363 | -0.363 | 0.363 |
| 176 | PHE | 268 | GLN | 0.362 | 0.000 | 0.362 | 0.362 |
| 103 | PHE | 107 | PHE | 0.246 | 0.605 | -0.359 | 0.359 |
| 37 | LEU | 41 | LEU | 0.000 | 0.359 | -0.359 | 0.359 |
| 207 | LEU | 242 | SER | 0.356 | 0.000 | 0.356 | 0.356 |
| 184 | TRP | 263 | VAL | 0.000 | 0.356 | -0.356 | 0.356 |
| 86 | SER | 87 | ILE | 0.000 | 0.354 | -0.354 | 0.354 |
| 46 | ARG | 311 | PHE | 0.354 | 0.000 | 0.354 | 0.354 |
| 108 | LEU | 150 | VAL | 1.609 | 1.962 | -0.352 | 0.352 |
| 90 | THR | 94 | ILE | 0.000 | 0.349 | -0.349 | 0.349 |
| 130 | LEU | 135 | GLN | 1.827 | 2.170 | -0.343 | 0.343 |
| 69 | LEU | 102 | SER | 0.000 | 0.340 | -0.340 | 0.340 |
| 296 | CYS | 317 | CYS | 0.000 | 0.337 | -0.337 | 0.337 |
| 302 | LYS | 303 | ASP | 0.630 | 0.293 | 0.336 | 0.336 |
| 48 | LYS | 50 | THR | 0.000 | 0.336 | -0.336 | 0.336 |
| 46 | ARG | 281 | TYR | 0.333 | 0.000 | 0.333 | 0.333 |
| 149 | SER | 150 | VAL | 0.000 | 0.330 | -0.330 | 0.330 |
| 240 | PHE | 292 | TYR | 2.397 | 2.068 | 0.329 | 0.329 |
| 189 | MET | 282 | PHE | 0.329 | 0.000 | 0.329 | 0.329 |
| 121 | CYS | 291 | VAL | 0.324 | 0.000 | 0.324 | 0.324 |
| 93 | HIS | 97 | PHE | 0.321 | 0.000 | 0.321 | 0.321 |
| 197 | PHE | 249 | LEU | 0.935 | 0.615 | 0.320 | 0.320 |
| 169 | ALA | 170 | TYR | 1.625 | 1.306 | 0.319 | 0.319 |
| 288 | ILE | 308 | LEU | 0.315 | 0.000 | 0.315 | 0.315 |
| 70 | LEU | 74 | SER | 0.314 | 0.000 | 0.314 | 0.314 |
| 309 | ASP | 312 | VAL | 1.762 | 2.073 | -0.312 | 0.312 |
| 213 | ILE | 220 | THR | 0.310 | 0.000 | 0.310 | 0.310 |
| 160 | ILE | 164 | LEU | 0.439 | 0.130 | 0.309 | 0.309 |
| 112 | VAL | 275 | MET | 0.309 | 0.000 | 0.309 | 0.309 |
| 56 | GLU | 292 | TYR | 0.000 | 0.305 | -0.305 | 0.305 |
| 92 | TYR | 161 | TYR | 0.000 | 0.305 | -0.305 | 0.305 |
| 138 | PHE | 142 | THR | 2.632 | 2.935 | -0.302 | 0.302 |
| 183 | TYR | 184 | TRP | 0.299 | 0.000 | 0.299 | 0.299 |
| 117 | CYS | 121 | CYS | 0.297 | 0.000 | 0.297 | 0.297 |
| 36 | ILE | 74 | SER | 0.000 | 0.294 | -0.294 | 0.294 |
| 214 | THR | 218 | ASN | 0.000 | 0.293 | -0.293 | 0.293 |
| 22 | LEU | 80 | ARG | 0.292 | 0.000 | 0.292 | 0.292 |
| 117 | CYS | 197 | PHE | 0.000 | 0.292 | -0.292 | 0.292 |
| 73 | ILE | 76 | ILE | 0.000 | 0.289 | -0.289 | 0.289 |
| 212 | ARG | 214 | THR | 0.288 | 0.000 | 0.288 | 0.288 |
| 233 | THR | 234 | VAL | 0.000 | 0.286 | -0.286 | 0.286 |
| 48 | LYS | 49 | ASN | 0.285 | 0.000 | 0.285 | 0.285 |
| 27 | LEU | 31 | ILE | 0.989 | 0.706 | 0.283 | 0.283 |
| 281 | TYR | 284 | ASN | 0.282 | 0.000 | 0.282 | 0.282 |
| 50 | THR | 56 | GLU | 0.281 | 0.000 | 0.281 | 0.281 |
| 115 | THR | 139 | TYR | 0.000 | 0.279 | -0.279 | 0.279 |
| 214 | THR | 223 | TYR | 0.278 | 0.000 | 0.278 | 0.278 |
| 113 | PHE | 189 | MET | 0.277 | 0.000 | 0.277 | 0.277 |
| 208 | VAL | 238 | LYS | 0.000 | 0.275 | -0.275 | 0.275 |
| 87 | ILE | 93 | HIS | 0.272 | 0.000 | 0.272 | 0.272 |
| 258 | LEU | 273 | ILE | 0.000 | 0.265 | -0.265 | 0.265 |
| 122 | LEU | 128 | THR | 0.263 | 0.000 | 0.263 | 0.263 |
| 261 | ILE | 267 | VAL | 0.262 | 0.000 | 0.262 | 0.262 |
| 55 | MET | 119 | ASP | 0.000 | 0.260 | -0.260 | 0.260 |
| 248 | PHE | 312 | VAL | 0.259 | 0.000 | 0.259 | 0.259 |
| 125 | SER | 126 | LYS | 0.000 | 0.258 | -0.258 | 0.258 |
| 95 | CYS | 164 | LEU | 0.000 | 0.256 | -0.256 | 0.256 |
| 32 | ILE | 66 | ASP | 0.255 | 0.000 | 0.255 | 0.255 |
| 73 | ILE | 77 | LEU | 0.909 | 1.164 | -0.254 | 0.254 |
| 208 | VAL | 246 | VAL | 0.254 | 0.000 | 0.254 | 0.254 |
| 120 | TYR | 234 | VAL | 0.000 | 0.250 | -0.250 | 0.250 |
| 213 | ILE | 222 | LEU | 0.249 | 0.000 | 0.249 | 0.249 |
| 42 | THR | 281 | TYR | 0.247 | 0.000 | 0.247 | 0.247 |
| 116 | ALA | 120 | TYR | 0.246 | 0.000 | 0.246 | 0.246 |
| 69 | LEU | 73 | ILE | 1.386 | 1.632 | -0.246 | 0.246 |
| 36 | ILE | 67 | LEU | 1.247 | 1.493 | -0.245 | 0.245 |
| 180 | ILE | 184 | TRP | 1.631 | 1.385 | 0.245 | 0.245 |
| 107 | PHE | 185 | LEU | 0.000 | 0.245 | -0.245 | 0.245 |
| 33 | LEU | 37 | LEU | 0.245 | 0.000 | 0.245 | 0.245 |
| 171 | SER | 175 | PRO | 0.284 | 0.529 | -0.244 | 0.244 |
| 42 | THR | 59 | CYS | 0.000 | 0.242 | -0.242 | 0.242 |
| 100 | ILE | 151 | LEU | 0.241 | 0.000 | 0.241 | 0.241 |
| 282 | PHE | 283 | VAL | 0.239 | 0.000 | 0.239 | 0.239 |
| 167 | GLN | 171 | SER | 0.238 | 0.000 | 0.238 | 0.238 |
| 208 | VAL | 234 | VAL | 0.000 | 0.238 | -0.238 | 0.238 |
| 64 | PHE | 68 | LEU | 3.651 | 3.416 | 0.236 | 0.236 |
| 121 | CYS | 203 | GLU | 0.000 | 0.236 | -0.236 | 0.236 |
| 172 | ARG | 173 | HIS | 0.000 | 0.234 | -0.234 | 0.234 |
| 95 | CYS | 99 | GLN | 0.555 | 0.322 | 0.233 | 0.233 |
| 79 | PHE | 94 | ILE | 0.000 | 0.232 | -0.232 | 0.232 |
| 294 | PHE | 295 | ASN | 0.231 | 0.000 | 0.231 | 0.231 |
| 272 | TYR | 276 | ASN | 0.000 | 0.230 | -0.230 | 0.230 |
| 226 | PHE | 230 | SER | 0.000 | 0.229 | -0.229 | 0.229 |
| 248 | PHE | 249 | LEU | 0.366 | 0.138 | 0.228 | 0.228 |
| 29 | PHE | 73 | ILE | 0.225 | 0.000 | 0.225 | 0.225 |
| 314 | TRP | 318 | PHE | 0.225 | 0.000 | 0.225 | 0.225 |
| 277 | ILE | 278 | PRO | 1.099 | 1.323 | -0.224 | 0.224 |
| 304 | ILE | 316 | CYS | 0.000 | 0.221 | -0.221 | 0.221 |
| 283 | VAL | 287 | LEU | 0.764 | 0.983 | -0.219 | 0.219 |
| 201 | TRP | 205 | THR | 2.530 | 2.311 | 0.218 | 0.218 |
| 99 | GLN | 103 | PHE | 0.000 | 0.215 | -0.215 | 0.215 |
| 48 | LYS | 318 | PHE | 0.000 | 0.215 | -0.215 | 0.215 |
| 126 | LYS | 305 | GLY | 0.214 | 0.000 | 0.214 | 0.214 |
| 323 | ILE | 324 | PRO | 0.215 | 0.429 | -0.214 | 0.214 |
| 164 | LEU | 167 | GLN | 0.000 | 0.212 | -0.212 | 0.212 |
| 52 | GLN | 132 | PHE | 4.948 | 4.736 | 0.212 | 0.212 |
| 183 | TYR | 266 | LYS | 0.207 | 0.000 | 0.207 | 0.207 |
| 55 | MET | 287 | LEU | 0.207 | 0.000 | 0.207 | 0.207 |
| 227 | SER | 229 | HIS | 0.000 | 0.207 | -0.207 | 0.207 |
| 104 | THR | 150 | VAL | 1.976 | 1.772 | 0.204 | 0.204 |
| 191 | MET | 253 | LEU | 0.000 | 0.203 | -0.203 | 0.203 |
| 187 | PHE | 188 | PHE | 0.201 | 0.000 | 0.201 | 0.201 |
| 108 | LEU | 112 | VAL | 0.201 | 0.000 | 0.201 | 0.201 |
| 138 | PHE | 139 | TYR | 0.861 | 0.662 | 0.198 | 0.198 |
| 183 | TYR | 263 | VAL | 1.511 | 1.709 | -0.198 | 0.198 |
| 100 | ILE | 164 | LEU | 0.198 | 0.000 | 0.198 | 0.198 |
| 100 | ILE | 160 | ILE | 0.000 | 0.197 | -0.197 | 0.197 |
| 153 | TYR | 154 | VAL | 0.115 | 0.310 | -0.195 | 0.195 |
| 163 | SER | 164 | LEU | 0.166 | 0.355 | -0.189 | 0.189 |
| 311 | PHE | 314 | TRP | 0.000 | 0.188 | -0.188 | 0.188 |
| 110 | TYR | 189 | MET | 0.000 | 0.188 | -0.188 | 0.188 |
| 241 | LEU | 244 | LEU | 0.000 | 0.187 | -0.187 | 0.187 |
| 204 | VAL | 208 | VAL | 0.402 | 0.215 | 0.186 | 0.186 |
| 261 | ILE | 266 | LYS | 0.063 | 0.246 | -0.184 | 0.184 |
| 92 | TYR | 93 | HIS | 1.209 | 1.392 | -0.182 | 0.182 |
| 106 | GLY | 177 | TYR | 0.181 | 0.000 | 0.181 | 0.181 |
| 331 | LYS | 332 | PRO | 0.305 | 0.483 | -0.179 | 0.179 |
| 115 | THR | 146 | ILE | 1.272 | 1.450 | -0.178 | 0.178 |
| 101 | ILE | 272 | TYR | 0.176 | 0.000 | 0.176 | 0.176 |
| 221 | ILE | 222 | LEU | 0.000 | 0.175 | -0.175 | 0.175 |
| 290 | THR | 294 | PHE | 1.548 | 1.723 | -0.174 | 0.174 |
| 76 | ILE | 102 | SER | 0.000 | 0.173 | -0.173 | 0.173 |
| 269 | ILE | 270 | PRO | 1.121 | 1.290 | -0.168 | 0.168 |
| 113 | PHE | 185 | LEU | 0.165 | 0.000 | 0.165 | 0.165 |
| 110 | TYR | 111 | PRO | 0.925 | 1.089 | -0.164 | 0.164 |
| 71 | VAL | 75 | ILE | 0.705 | 0.541 | 0.164 | 0.164 |
| 279 | TRP | 282 | PHE | 0.000 | 0.161 | -0.161 | 0.161 |
| 245 | ILE | 249 | LEU | 1.081 | 0.920 | 0.161 | 0.161 |
| 32 | ILE | 36 | ILE | 0.525 | 0.685 | -0.161 | 0.161 |
| 29 | PHE | 33 | LEU | 0.302 | 0.142 | 0.160 | 0.160 |
| 247 | CYS | 316 | CYS | 0.159 | 0.000 | 0.159 | 0.159 |
| 131 | SER | 133 | LYS | 0.158 | 0.000 | 0.158 | 0.158 |
| 333 | ILE | 334 | SER | 0.158 | 0.000 | 0.158 | 0.158 |
| 122 | LEU | 125 | SER | 0.000 | 0.157 | -0.157 | 0.157 |
| 144 | ILE | 148 | ILE | 1.080 | 0.924 | 0.156 | 0.156 |
| 93 | HIS | 96 | LEU | 0.152 | 0.000 | 0.152 | 0.152 |
| 202 | GLU | 205 | THR | 0.000 | 0.152 | -0.152 | 0.152 |
| 186 | SER | 190 | VAL | 0.207 | 0.062 | 0.145 | 0.145 |
| 20 | GLN | 21 | PRO | 0.647 | 0.502 | 0.145 | 0.145 |
| 104 | THR | 105 | TYR | 0.144 | 0.000 | 0.144 | 0.144 |
| 25 | ASN | 80 | ARG | 0.000 | 0.144 | -0.144 | 0.144 |
| 132 | PHE | 135 | GLN | 0.000 | 0.138 | -0.138 | 0.138 |
| 29 | PHE | 30 | LEU | 0.137 | 0.000 | 0.137 | 0.137 |
| 55 | MET | 241 | LEU | 0.000 | 0.137 | -0.137 | 0.137 |
| 307 | PRO | 314 | TRP | 0.135 | 0.000 | 0.135 | 0.135 |
| 150 | VAL | 154 | VAL | 0.253 | 0.120 | 0.133 | 0.133 |
| 253 | LEU | 254 | PRO | 1.020 | 0.887 | 0.133 | 0.133 |
| 38 | LEU | 42 | THR | 0.133 | 0.000 | 0.133 | 0.133 |
| 130 | LEU | 138 | PHE | 0.131 | 0.000 | 0.131 | 0.131 |
| 177 | TYR | 269 | ILE | 0.130 | 0.000 | 0.130 | 0.130 |
| 256 | VAL | 260 | VAL | 0.129 | 0.000 | 0.129 | 0.129 |
| 252 | TRP | 256 | VAL | 0.128 | 0.000 | 0.128 | 0.128 |
| 53 | ASN | 123 | ASN | 0.128 | 0.000 | 0.128 | 0.128 |
| 319 | ILE | 320 | PRO | 0.611 | 0.737 | -0.125 | 0.125 |
| 58 | PHE | 146 | ILE | 0.122 | 0.000 | 0.122 | 0.122 |
| 179 | SER | 181 | GLN | 0.688 | 0.566 | 0.122 | 0.122 |
| 107 | PHE | 177 | TYR | 0.120 | 0.000 | 0.120 | 0.120 |
| 75 | ILE | 80 | ARG | 0.119 | 0.000 | 0.119 | 0.119 |
| 57 | TYR | 140 | PHE | 0.118 | 0.000 | 0.118 | 0.118 |
| 278 | PRO | 282 | PHE | 0.000 | 0.118 | -0.118 | 0.118 |
| 113 | PHE | 193 | LEU | 0.000 | 0.115 | -0.115 | 0.115 |
| 104 | THR | 108 | LEU | 0.896 | 0.782 | 0.114 | 0.114 |
| 111 | PRO | 150 | VAL | 0.315 | 0.427 | -0.112 | 0.112 |
| 28 | LEU | 73 | ILE | 0.108 | 0.000 | 0.108 | 0.108 |
| 212 | ARG | 215 | SER | 0.000 | 0.107 | -0.107 | 0.107 |
| 76 | ILE | 89 | PHE | 0.106 | 0.000 | 0.106 | 0.106 |
| 157 | ASP | 158 | PRO | 2.046 | 1.943 | 0.103 | 0.103 |
| 123 | ASN | 305 | GLY | 0.101 | 0.000 | 0.101 | 0.101 |
| 242 | SER | 246 | VAL | 0.000 | 0.100 | -0.100 | 0.100 |
| 248 | PHE | 253 | LEU | 0.136 | 0.037 | 0.098 | 0.098 |
| 202 | GLU | 206 | THR | 0.000 | 0.096 | -0.096 | 0.096 |
| 215 | SER | 216 | TYR | 0.000 | 0.096 | -0.096 | 0.096 |
| 142 | THR | 146 | ILE | 0.507 | 0.602 | -0.095 | 0.095 |
| 299 | LEU | 300 | ASN | 0.000 | 0.091 | -0.091 | 0.091 |
| 205 | THR | 206 | THR | 0.058 | 0.150 | -0.091 | 0.091 |
| 25 | ASN | 91 | LYS | 0.091 | 0.000 | 0.091 | 0.091 |
| 55 | MET | 58 | PHE | 0.000 | 0.091 | -0.091 | 0.091 |
| 47 | ARG | 311 | PHE | 0.089 | 0.000 | 0.089 | 0.089 |
| 68 | LEU | 72 | ASN | 0.088 | 0.000 | 0.088 | 0.088 |
| 47 | ARG | 312 | VAL | 0.087 | 0.000 | 0.087 | 0.087 |
| 158 | PRO | 162 | GLN | 0.000 | 0.086 | -0.086 | 0.086 |
| 67 | LEU | 71 | VAL | 0.090 | 0.004 | 0.086 | 0.086 |
| 43 | LEU | 46 | ARG | 0.085 | 0.000 | 0.085 | 0.085 |
| 296 | CYS | 299 | LEU | 0.083 | 0.000 | 0.083 | 0.083 |
| 195 | VAL | 199 | THR | 0.288 | 0.206 | 0.082 | 0.082 |
| 204 | VAL | 238 | LYS | 0.000 | 0.082 | -0.082 | 0.082 |
| 100 | ILE | 161 | TYR | 0.000 | 0.081 | -0.081 | 0.081 |
| 219 | GLU | 335 | ILE | 0.081 | 0.000 | 0.081 | 0.081 |
| 45 | MET | 296 | CYS | 0.000 | 0.079 | -0.079 | 0.079 |
| 271 | ALA | 274 | GLU | 0.079 | 0.000 | 0.079 | 0.079 |
| 161 | TYR | 165 | LYS | 0.078 | 0.000 | 0.078 | 0.078 |
| 94 | ILE | 98 | THR | 0.136 | 0.215 | -0.078 | 0.078 |
| 231 | SER | 236 | SER | 0.077 | 0.000 | 0.077 | 0.077 |
| 247 | CYS | 313 | ASN | 0.074 | 0.000 | 0.074 | 0.074 |
| 100 | ILE | 104 | THR | 0.364 | 0.438 | -0.073 | 0.073 |
| 174 | CYS | 175 | PRO | 0.244 | 0.171 | 0.073 | 0.073 |
| 32 | ILE | 272 | TYR | 0.073 | 0.000 | 0.073 | 0.073 |
| 235 | ARG | 239 | ILE | 0.660 | 0.587 | 0.072 | 0.072 |
| 197 | PHE | 198 | ILE | 0.000 | 0.072 | -0.072 | 0.072 |
| 218 | ASN | 226 | PHE | 0.000 | 0.067 | -0.067 | 0.067 |
| 186 | SER | 256 | VAL | 0.000 | 0.066 | -0.066 | 0.066 |
| 199 | THR | 200 | CYS | 0.066 | 0.000 | 0.066 | 0.066 |
| 152 | ALA | 157 | ASP | 0.065 | 0.000 | 0.065 | 0.065 |
| 100 | ILE | 155 | LEU | 0.870 | 0.810 | 0.061 | 0.061 |
| 89 | PHE | 93 | HIS | 3.301 | 3.243 | 0.058 | 0.058 |
| 36 | ILE | 40 | ILE | 0.960 | 0.902 | 0.058 | 0.058 |
| 178 | VAL | 271 | ALA | 0.057 | 0.000 | 0.057 | 0.057 |
| 99 | GLN | 174 | CYS | 0.056 | 0.000 | 0.056 | 0.056 |
| 105 | TYR | 108 | LEU | 0.625 | 0.678 | -0.053 | 0.053 |
| 196 | ALA | 199 | THR | 0.000 | 0.053 | -0.053 | 0.053 |
| 47 | ARG | 309 | ASP | 0.052 | 0.000 | 0.052 | 0.052 |
| 228 | SER | 229 | HIS | 0.022 | 0.072 | -0.051 | 0.051 |
| 147 | TRP | 151 | LEU | 0.048 | 0.000 | 0.048 | 0.048 |
| 260 | VAL | 264 | LEU | 1.174 | 1.222 | -0.048 | 0.048 |
| 140 | PHE | 144 | ILE | 3.313 | 3.358 | -0.045 | 0.045 |
| 241 | LEU | 245 | ILE | 1.904 | 1.859 | 0.045 | 0.045 |
| 207 | LEU | 210 | ALA | 0.000 | 0.045 | -0.045 | 0.045 |
| 261 | ILE | 265 | LEU | 0.930 | 0.886 | 0.043 | 0.043 |
| 324 | PRO | 325 | ASN | 0.000 | 0.040 | -0.040 | 0.040 |
| 281 | TYR | 309 | ASP | 0.040 | 0.000 | 0.040 | 0.040 |
| 321 | LEU | 323 | ILE | 0.000 | 0.040 | -0.040 | 0.040 |
| 243 | LYS | 316 | CYS | 0.039 | 0.000 | 0.039 | 0.039 |
| 295 | ASN | 297 | HIS | 0.038 | 0.000 | 0.038 | 0.038 |
| 249 | LEU | 253 | LEU | 0.038 | 0.000 | 0.038 | 0.038 |
| 236 | SER | 237 | LYS | 0.000 | 0.037 | -0.037 | 0.037 |
| 243 | LYS | 319 | ILE | 0.036 | 0.000 | 0.036 | 0.036 |
| 231 | SER | 232 | TYR | 0.000 | 0.036 | -0.036 | 0.036 |
| 248 | PHE | 288 | ILE | 0.000 | 0.036 | -0.036 | 0.036 |
| 190 | VAL | 191 | MET | 0.481 | 0.447 | 0.034 | 0.034 |
| 242 | SER | 243 | LYS | 0.034 | 0.000 | 0.034 | 0.034 |
| 56 | GLU | 281 | TYR | 0.033 | 0.000 | 0.033 | 0.033 |
| 109 | HIS | 274 | GLU | 0.032 | 0.000 | 0.032 | 0.032 |
| 146 | ILE | 150 | VAL | 0.005 | 0.037 | -0.032 | 0.032 |
| 58 | PHE | 62 | LEU | 0.030 | 0.000 | 0.030 | 0.030 |
| 124 | PHE | 306 | LEU | 0.030 | 0.000 | 0.030 | 0.030 |
| 118 | ILE | 122 | LEU | 1.047 | 1.017 | 0.029 | 0.029 |
| 278 | PRO | 281 | TYR | 0.000 | 0.029 | -0.029 | 0.029 |
| 119 | ASP | 120 | TYR | 0.027 | 0.000 | 0.027 | 0.027 |
| 315 | LYS | 319 | ILE | 0.025 | 0.000 | 0.025 | 0.025 |
| 146 | ILE | 147 | TRP | 0.000 | 0.024 | -0.024 | 0.024 |
| 153 | TYR | 181 | GLN | 0.000 | 0.022 | -0.022 | 0.022 |
| 179 | SER | 269 | ILE | 0.022 | 0.000 | 0.022 | 0.022 |
| 151 | LEU | 156 | GLY | 0.021 | 0.000 | 0.021 | 0.021 |
| 211 | ILE | 225 | PRO | 0.021 | 0.000 | 0.021 | 0.021 |
| 41 | LEU | 314 | TRP | 0.000 | 0.020 | -0.020 | 0.020 |
| 53 | ASN | 307 | PRO | 0.020 | 0.000 | 0.020 | 0.020 |
| 143 | VAL | 147 | TRP | 1.306 | 1.326 | -0.020 | 0.020 |
| 215 | SER | 220 | THR | 0.020 | 0.000 | 0.020 | 0.020 |
| 80 | ARG | 275 | MET | 0.000 | 0.019 | -0.019 | 0.019 |
| 16 | ARG | 20 | GLN | 0.016 | 0.000 | 0.016 | 0.016 |
| 127 | THR | 128 | THR | 0.192 | 0.208 | -0.016 | 0.016 |
| 38 | LEU | 293 | TRP | 0.000 | 0.014 | -0.014 | 0.014 |
| 128 | THR | 130 | LEU | 0.000 | 0.012 | -0.012 | 0.012 |
| 62 | LEU | 288 | ILE | 0.000 | 0.011 | -0.011 | 0.011 |
| 50 | THR | 320 | PRO | 0.000 | 0.011 | -0.011 | 0.011 |
| 245 | ILE | 250 | SER | 0.010 | 0.000 | 0.010 | 0.010 |
| 61 | SER | 65 | VAL | 0.000 | 0.010 | -0.010 | 0.010 |
| 98 | THR | 102 | SER | 0.255 | 0.246 | 0.009 | 0.009 |
| 308 | LEU | 315 | LYS | 0.009 | 0.000 | 0.009 | 0.009 |
| 204 | VAL | 245 | ILE | 0.009 | 0.000 | 0.009 | 0.009 |
RRCS change distribution
0.31
Mean ΔRRCS
2.68
Std Dev
0.16
Median
Magnitude classification
64
High (|Δ| ≥ 5.0)
29
Medium (3.8 ≤ |Δ| < 5.0)
751
Low (|Δ| < 3.8)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 3.78, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar