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LGR4

Gene LGR4 Class A orphans Orphan receptors UniProt Q9BXB1
UniProt ↗ GPCRdb ↗ NCBI Gene ↗
2490
Total Contact Pairs
311
Significant Changes
11.71
Max Increase
-13.49
Max Decrease

Interactive snake plot

GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.

Color convention: blue = active-favoring, red = inactive-favoring.

ICL1 C567 C567 C T568 T568 T S569 S569 S L570 L570 L ICL1ECL1 G603 G603 G R604 R604 R F605 F605 F A606 A606 A E607 E607 E F608 F608 F G609 G609 G I610 I610 I W611 W611 W W612 W612 W E613 E613 E T614 T614 T G615 G615 G ECL1ICL2 I650 34.50x50 I650 34.50x50 I M651 34.51x51 M651 34.51x51 M K652 34.52x52 K652 34.52x52 K N653 34.53x53 N653 34.53x53 N G654 34.54x54 G654 34.54x54 G K655 34.55x55 K655 34.55x55 K S656 34.56x56 S656 34.56x56 S N657 34.57x57 N657 34.57x57 N ICL2ECL2 R684 R684 R G685 G685 G E686 E686 E Y687 Y687 Y S688 S688 S A689 A689 A S690 S690 S P691 P691 P L692 L692 L C693 45.50x50 C693 45.50x50 C L694 45.51x51 L694 45.51x51 L P695 45.52x52 P695 45.52x52 P F696 F696 F P697 P697 P T698 T698 T G699 G699 G E700 E700 E T701 T701 T P702 P702 P ECL2ICL3 E735 E735 E D736 D736 D L737 L737 L S738 S738 S E739 E739 E ICL3ECL3 A774 A774 A I775 I775 I S776 S776 S I777 I777 I ECL3N-term M1 M1 M P2 P2 P G3 G3 G P4 P4 P L5 L5 L G6 G6 G L7 L7 L L8 L8 L C9 C9 C F10 F10 F L11 L11 L A12 A12 A L13 L13 L G14 G14 G L15 L15 L L16 L16 L G17 G17 G S18 S18 S A19 A19 A G20 G20 G P21 P21 P S22 S22 S G23 G23 G A24 A24 A A25 A25 A P26 P26 P P27 P27 P L28 L28 L C29 C29 C A30 A30 A A31 A31 A P32 P32 P C33 C33 C S34 S34 S C35 C35 C D36 D36 D G37 G37 G D38 D38 D R39 R39 R R40 R40 R V41 V41 V D42 D42 D C43 C43 C S44 S44 S G45 G45 G K46 K46 K G47 G47 G L48 L48 L T49 T49 T A50 A50 A V51 V51 V P52 P52 P E53 E53 E G54 G54 G L55 L55 L S56 S56 S A57 A57 A F58 F58 F T59 T59 T Q60 Q60 Q A61 A61 A L62 L62 L D63 D63 D I64 I64 I S65 S65 S M66 M66 M N67 N67 N N68 N68 N I69 I69 I T70 T70 T Q71 Q71 Q L72 L72 L P73 P73 P E74 E74 E D75 D75 D A76 A76 A F77 F77 F K78 K78 K N79 N79 N F80 F80 F P81 P81 P F82 F82 F L83 L83 L E84 E84 E E85 E85 E L86 L86 L Q87 Q87 Q L88 L88 L A89 A89 A G90 G90 G N91 N91 N D92 D92 D L93 L93 L S94 S94 S F95 F95 F I96 I96 I H97 H97 H P98 P98 P K99 K99 K A100 A100 A L101 L101 L S102 S102 S G103 G103 G L104 L104 L K105 K105 K E106 E106 E L107 L107 L K108 K108 K V109 V109 V L110 L110 L T111 T111 T L112 L112 L Q113 Q113 Q N114 N114 N N115 N115 N Q116 Q116 Q L117 L117 L K118 K118 K T119 T119 T V120 V120 V P121 P121 P S122 S122 S E123 E123 E A124 A124 A I125 I125 I R126 R126 R G127 G127 G L128 L128 L S129 S129 S A130 A130 A L131 L131 L Q132 Q132 Q S133 S133 S L134 L134 L R135 R135 R L136 L136 L D137 D137 D A138 A138 A N139 N139 N H140 H140 H I141 I141 I T142 T142 T S143 S143 S V144 V144 V P145 P145 P E146 E146 E D147 D147 D S148 S148 S F149 F149 F E150 E150 E G151 G151 G L152 L152 L V153 V153 V Q154 Q154 Q L155 L155 L R156 R156 R H157 H157 H L158 L158 L W159 W159 W L160 L160 L D161 D161 D D162 D162 D N163 N163 N S164 S164 S L165 L165 L T166 T166 T E167 E167 E V168 V168 V P169 P169 P V170 V170 V H171 H171 H P172 P172 P L173 L173 L S174 S174 S N175 N175 N L176 L176 L P177 P177 P T178 T178 T L179 L179 L Q180 Q180 Q A181 A181 A L182 L182 L T183 T183 T L184 L184 L A185 A185 A L186 L186 L N187 N187 N K188 K188 K I189 I189 I S190 S190 S S191 S191 S I192 I192 I P193 P193 P D194 D194 D F195 F195 F A196 A196 A F197 F197 F T198 T198 T N199 N199 N L200 L200 L S201 S201 S S202 S202 S L203 L203 L V204 V204 V V205 V205 V L206 L206 L H207 H207 H L208 L208 L H209 H209 H N210 N210 N N211 N211 N K212 K212 K I213 I213 I R214 R214 R S215 S215 S L216 L216 L S217 S217 S Q218 Q218 Q H219 H219 H C220 C220 C F221 F221 F D222 D222 D G223 G223 G L224 L224 L D225 D225 D N226 N226 N L227 L227 L E228 E228 E T229 T229 T L230 L230 L D231 D231 D L232 L232 L N233 N233 N Y234 Y234 Y N235 N235 N N236 N236 N L237 L237 L G238 G238 G E239 E239 E F240 F240 F P241 P241 P Q242 Q242 Q A243 A243 A I244 I244 I K245 K245 K A246 A246 A L247 L247 L P248 P248 P S249 S249 S L250 L250 L K251 K251 K E252 E252 E L253 L253 L G254 G254 G F255 F255 F H256 H256 H S257 S257 S N258 N258 N S259 S259 S I260 I260 I S261 S261 S V262 V262 V I263 I263 I P264 P264 P D265 D265 D G266 G266 G A267 A267 A F268 F268 F D269 D269 D G270 G270 G N271 N271 N P272 P272 P L273 L273 L L274 L274 L R275 R275 R T276 T276 T I277 I277 I H278 H278 H L279 L279 L Y280 Y280 Y D281 D281 D N282 N282 N P283 P283 P L284 L284 L S285 S285 S F286 F286 F V287 V287 V G288 G288 G N289 N289 N S290 S290 S A291 A291 A F292 F292 F H293 H293 H N294 N294 N L295 L295 L S296 S296 S D297 D297 D L298 L298 L H299 H299 H S300 S300 S L301 L301 L V302 V302 V I303 I303 I R304 R304 R G305 G305 G A306 A306 A S307 S307 S M308 M308 M V309 V309 V Q310 Q310 Q Q311 Q311 Q F312 F312 F P313 P313 P N314 N314 N L315 L315 L T316 T316 T G317 G317 G T318 T318 T V319 V319 V H320 H320 H L321 L321 L E322 E322 E S323 S323 S L324 L324 L T325 T325 T L326 L326 L T327 T327 T G328 G328 G T329 T329 T K330 K330 K I331 I331 I S332 S332 S S333 S333 S I334 I334 I P335 P335 P N336 N336 N N337 N337 N L338 L338 L C339 C339 C Q340 Q340 Q E341 E341 E Q342 Q342 Q K343 K343 K M344 M344 M L345 L345 L R346 R346 R T347 T347 T L348 L348 L D349 D349 D L350 L350 L S351 S351 S Y352 Y352 Y N353 N353 N N354 N354 N I355 I355 I R356 R356 R D357 D357 D L358 L358 L P359 P359 P S360 S360 S F361 F361 F N362 N362 N G363 G363 G C364 C364 C H365 H365 H A366 A366 A L367 L367 L E368 E368 E E369 E369 E I370 I370 I S371 S371 S L372 L372 L Q373 Q373 Q R374 R374 R N375 N375 N Q376 Q376 Q I377 I377 I Y378 Y378 Y Q379 Q379 Q I380 I380 I K381 K381 K E382 E382 E G383 G383 G T384 T384 T F385 F385 F Q386 Q386 Q G387 G387 G L388 L388 L I389 I389 I S390 S390 S L391 L391 L R392 R392 R I393 I393 I L394 L394 L D395 D395 D L396 L396 L S397 S397 S R398 R398 R N399 N399 N L400 L400 L I401 I401 I H402 H402 H E403 E403 E I404 I404 I H405 H405 H S406 S406 S R407 R407 R A408 A408 A F409 F409 F A410 A410 A T411 T411 T L412 L412 L G413 G413 G P414 P414 P I415 I415 I T416 T416 T N417 N417 N L418 L418 L D419 D419 D V420 V420 V S421 S421 S F422 F422 F N423 N423 N E424 E424 E L425 L425 L T426 T426 T S427 S427 S F428 F428 F P429 P429 P T430 T430 T E431 E431 E G432 G432 G L433 L433 L N434 N434 N G435 G435 G L436 L436 L N437 N437 N Q438 Q438 Q L439 L439 L K440 K440 K L441 L441 L V442 V442 V G443 G443 G N444 N444 N F445 F445 F K446 K446 K L447 L447 L K448 K448 K E449 E449 E A450 A450 A L451 L451 L A452 A452 A A453 A453 A K454 K454 K D455 D455 D F456 F456 F V457 V457 V N458 N458 N L459 L459 L R460 R460 R S461 S461 S L462 L462 L S463 S463 S V464 V464 V P465 P465 P Y466 Y466 Y A467 A467 A Y468 Y468 Y Q469 Q469 Q C470 C470 C C471 C471 C A472 A472 A F473 F473 F W474 W474 W G475 G475 G C476 C476 C D477 D477 D S478 S478 S Y479 Y479 Y A480 A480 A N481 N481 N L482 L482 L N483 N483 N T484 T484 T E485 E485 E D486 D486 D N487 N487 N S488 S488 S L489 L489 L Q490 Q490 Q D491 D491 D H492 H492 H S493 S493 S V494 V494 V A495 A495 A Q496 Q496 Q E497 E497 E K498 K498 K G499 G499 G T500 T500 T A501 A501 A D502 D502 D A503 A503 A A504 A504 A N505 N505 N V506 V506 V T507 T507 T S508 S508 S T509 T509 T L510 L510 L E511 E511 E N512 N512 N E513 E513 E E514 E514 E H515 H515 H S516 S516 S Q517 Q517 Q I518 I518 I I519 I519 I I520 I520 I H521 H521 H C522 C522 C T523 T523 T P524 P524 P S525 S525 S T526 T526 T G527 G527 G A528 A528 A F529 F529 F K530 K530 K P531 P531 P C532 C532 C E533 E533 E Y534 Y534 Y L535 L535 L L536 L536 L G537 G537 G N-termC-term T820 T820 T K821 K821 K K822 K822 K S823 S823 S G824 G824 G S825 S825 S V826 V826 V S827 S827 S V828 V828 V S829 S829 S I830 I830 I S831 S831 S S832 S832 S Q833 Q833 Q G834 G834 G G835 G835 G C836 C836 C L837 L837 L E838 E838 E Q839 Q839 Q D840 D840 D F841 F841 F Y842 Y842 Y Y843 Y843 Y D844 D844 D C845 C845 C G846 G846 G M847 M847 M Y848 Y848 Y S849 S849 S H850 H850 H L851 L851 L Q852 Q852 Q G853 G853 G N854 N854 N L855 L855 L T856 T856 T V857 V857 V C858 C858 C D859 D859 D C860 C860 C C861 C861 C E862 E862 E S863 S863 S F864 F864 F L865 L865 L L866 L866 L T867 T867 T K868 K868 K P869 P869 P V870 V870 V S871 S871 S C872 C872 C K873 K873 K H874 H874 H L875 L875 L I876 I876 I K877 K877 K S878 S878 S H879 H879 H S880 S880 S C881 C881 C P882 P882 P A883 A883 A L884 L884 L A885 A885 A V886 V886 V A887 A887 A S888 S888 S C889 C889 C Q890 Q890 Q R891 R891 R P892 P892 P E893 E893 E G894 G894 G Y895 Y895 Y W896 W896 W S897 S897 S D898 D898 D C899 C899 C G900 G900 G T901 T901 T Q902 Q902 Q S903 S903 S A904 A904 A H905 H905 H S906 S906 S D907 D907 D Y908 Y908 Y A909 A909 A D910 D910 D E911 E911 E E912 E912 E D913 D913 D S914 S914 S F915 F915 F V916 V916 V S917 S917 S D918 D918 D S919 S919 S S920 S920 S D921 D921 D Q922 Q922 Q V923 V923 V Q924 Q924 Q A925 A925 A C926 C926 C G927 G927 G R928 R928 R A929 A929 A C930 C930 C F931 F931 F Y932 Y932 Y Q933 Q933 Q S934 S934 S R935 R935 R G936 G936 G F937 F937 F P938 P938 P L939 L939 L V940 V940 V R941 R941 R Y942 Y942 Y A943 A943 A Y944 Y944 Y N945 N945 N L946 L946 L P947 P947 P R948 R948 R V949 V949 V K950 K950 K D951 D951 D C-term S538 1.32x32 S538 1.32x32 S W539 1.33x33 W539 1.33x33 W M540 1.34x34 M540 1.34x34 M I541 1.35x35 I541 1.35x35 I R542 1.36x36 R542 1.36x36 R L543 1.37x37 L543 1.37x37 L T544 1.38x38 T544 1.38x38 T V545 1.39x39 V545 1.39x39 V W546 1.40x40 W546 1.40x40 W F547 1.41x41 F547 1.41x41 F I548 1.42x42 I548 1.42x42 I F549 1.43x43 F549 1.43x43 F L550 1.44x44 L550 1.44x44 L V551 1.45x45 V551 1.45x45 V A552 1.46x46 A552 1.46x46 A L553 1.47x47 L553 1.47x47 L F554 1.48x48 F554 1.48x48 F F555 1.49x49 F555 1.49x49 F N556 1.50x50 N556 1.50x50 N L557 1.51x51 L557 1.51x51 L L558 1.52x52 L558 1.52x52 L V559 1.53x53 V559 1.53x53 V I560 1.54x54 I560 1.54x54 I L561 1.55x55 L561 1.55x55 L T562 1.56x56 T562 1.56x56 T T563 1.57x57 T563 1.57x57 T F564 1.58x58 F564 1.58x58 F A565 1.59x59 A565 1.59x59 A S566 1.60x60 S566 1.60x60 S P571 2.37x37 P571 2.37x37 P S572 2.38x38 S572 2.38x38 S S573 2.39x39 S573 2.39x39 S K574 2.40x40 K574 2.40x40 K L575 2.41x41 L575 2.41x41 L F576 2.42x42 F576 2.42x42 F I577 2.43x43 I577 2.43x43 I G578 2.44x44 G578 2.44x44 G L579 2.45x45 L579 2.45x45 L I580 2.46x46 I580 2.46x46 I S581 2.47x47 S581 2.47x47 S V582 2.48x48 V582 2.48x48 V S583 2.49x49 S583 2.49x49 S N584 2.50x50 N584 2.50x50 N L585 2.51x51 L585 2.51x51 L F586 2.52x52 F586 2.52x52 F M587 2.53x53 M587 2.53x53 M G588 2.54x54 G588 2.54x54 G I589 2.55x55 I589 2.55x55 I Y590 2.56x56 Y590 2.56x56 Y T591 2.57x57 T591 2.57x57 T G592 2.58x58 G592 2.58x58 G I593 2.59x59 I593 2.59x59 I L594 2.60x60 L594 2.60x60 L T595 2.61x61 T595 2.61x61 T F596 2.62x62 F596 2.62x62 F L597 2.63x63 L597 2.63x63 L D598 2.64x64 D598 2.64x64 D A599 2.65x65 A599 2.65x65 A V600 2.66x66 V600 2.66x66 V S601 2.67x67 S601 2.67x67 S W602 2.68x68 W602 2.68x68 W S616 3.23x23 S616 3.23x23 S G617 3.24x24 G617 3.24x24 G C618 3.25x25 C618 3.25x25 C K619 3.26x26 K619 3.26x26 K V620 3.27x27 V620 3.27x27 V A621 3.28x28 A621 3.28x28 A G622 3.29x29 G622 3.29x29 G F623 3.30x30 F623 3.30x30 F L624 3.31x31 L624 3.31x31 L A625 3.32x32 A625 3.32x32 A V626 3.33x33 V626 3.33x33 V F627 3.34x34 F627 3.34x34 F S628 3.35x35 S628 3.35x35 S S629 3.36x36 S629 3.36x36 S E630 3.37x37 E630 3.37x37 E S631 3.38x38 S631 3.38x38 S A632 3.39x39 A632 3.39x39 A I633 3.40x40 I633 3.40x40 I F634 3.41x41 F634 3.41x41 F L635 3.42x42 L635 3.42x42 L L636 3.43x43 L636 3.43x43 L M637 3.44x44 M637 3.44x44 M L638 3.45x45 L638 3.45x45 L A639 3.46x46 A639 3.46x46 A T640 3.47x47 T640 3.47x47 T V641 3.48x48 V641 3.48x48 V E642 3.49x49 E642 3.49x49 E R643 3.50x50 R643 3.50x50 R S644 3.51x51 S644 3.51x51 S L645 3.52x52 L645 3.52x52 L S646 3.53x53 S646 3.53x53 S A647 3.54x54 A647 3.54x54 A K648 3.55x55 K648 3.55x55 K D649 3.56x56 D649 3.56x56 D H658 4.38x38 H658 4.38x38 H L659 4.39x39 L659 4.39x39 L K660 4.40x40 K660 4.40x40 K Q661 4.41x41 Q661 4.41x41 Q F662 4.42x42 F662 4.42x42 F R663 4.43x43 R663 4.43x43 R V664 4.44x44 V664 4.44x44 V A665 4.45x45 A665 4.45x45 A A666 4.46x46 A666 4.46x46 A L667 4.47x47 L667 4.47x47 L L668 4.48x48 L668 4.48x48 L A669 4.49x49 A669 4.49x49 A F670 4.50x50 F670 4.50x50 F L671 4.51x51 L671 4.51x51 L G672 4.52x52 G672 4.52x52 G A673 4.53x53 A673 4.53x53 A T674 4.54x54 T674 4.54x54 T V675 4.55x55 V675 4.55x55 V A676 4.56x56 A676 4.56x56 A G677 4.57x57 G677 4.57x57 G C678 4.58x58 C678 4.58x58 C F679 4.59x59 F679 4.59x59 F P680 4.60x60 P680 4.60x60 P L681 4.61x61 L681 4.61x61 L F682 4.62x62 F682 4.62x62 F H683 4.63x63 H683 4.63x63 H S703 5.36x36 S703 5.36x36 S L704 5.37x37 L704 5.37x37 L G705 5.38x38 G705 5.38x38 G F706 5.39x39 F706 5.39x39 F T707 5.40x40 T707 5.40x40 T V708 5.41x41 V708 5.41x41 V T709 5.42x42 T709 5.42x42 T L710 5.43x43 L710 5.43x43 L V711 5.44x44 V711 5.44x44 V L712 5.45x45 L712 5.45x45 L L713 5.46x46 L713 5.46x46 L N714 5.47x47 N714 5.47x47 N S715 5.48x48 S715 5.48x48 S L716 5.49x49 L716 5.49x49 L A717 5.50x50 A717 5.50x50 A F718 5.51x51 F718 5.51x51 F L719 5.52x52 L719 5.52x52 L L720 5.53x53 L720 5.53x53 L M721 5.54x54 M721 5.54x54 M A722 5.55x55 A722 5.55x55 A V723 5.56x56 V723 5.56x56 V I724 5.57x57 I724 5.57x57 I Y725 5.58x58 Y725 5.58x58 Y T726 5.59x59 T726 5.59x59 T K727 5.60x60 K727 5.60x60 K L728 5.61x61 L728 5.61x61 L Y729 5.62x62 Y729 5.62x62 Y C730 5.63x63 C730 5.63x63 C N731 5.64x64 N731 5.64x64 N L732 5.65x65 L732 5.65x65 L E733 5.66x66 E733 5.66x66 E K734 5.67x67 K734 5.67x67 K N740 6.28x28 N740 6.28x28 N S741 6.29x29 S741 6.29x29 S Q742 6.30x30 Q742 6.30x30 Q S743 6.31x31 S743 6.31x31 S S744 6.32x32 S744 6.32x32 S M745 6.33x33 M745 6.33x33 M I746 6.34x34 I746 6.34x34 I K747 6.35x35 K747 6.35x35 K H748 6.36x36 H748 6.36x36 H V749 6.37x37 V749 6.37x37 V A750 6.38x38 A750 6.38x38 A W751 6.39x39 W751 6.39x39 W L752 6.40x40 L752 6.40x40 L I753 6.41x41 I753 6.41x41 I F754 6.42x42 F754 6.42x42 F T755 6.43x43 T755 6.43x43 T N756 6.44x44 N756 6.44x44 N C757 6.45x45 C757 6.45x45 C I758 6.46x46 I758 6.46x46 I F759 6.47x47 F759 6.47x47 F F760 6.48x48 F760 6.48x48 F C761 6.49x49 C761 6.49x49 C P762 6.50x50 P762 6.50x50 P V763 6.51x51 V763 6.51x51 V A764 6.52x52 A764 6.52x52 A F765 6.53x53 F765 6.53x53 F F766 6.54x54 F766 6.54x54 F S767 6.55x55 S767 6.55x55 S F768 6.56x56 F768 6.56x56 F A769 6.57x57 A769 6.57x57 A P770 6.58x58 P770 6.58x58 P L771 6.59x59 L771 6.59x59 L I772 6.60x60 I772 6.60x60 I T773 6.61x61 T773 6.61x61 T S778 7.30x29 S778 7.30x29 S P779 7.31x30 P779 7.31x30 P E780 7.32x31 E780 7.32x31 E I781 7.33x32 I781 7.33x32 I M782 7.34x33 M782 7.34x33 M K783 7.35x34 K783 7.35x34 K S784 7.36x35 S784 7.36x35 S V785 7.37x36 V785 7.37x36 V T786 7.38x37 T786 7.38x37 T L787 7.39x38 L787 7.39x38 L I788 7.40x39 I788 7.40x39 I F789 7.41x40 F789 7.41x40 F F790 7.42x41 F790 7.42x41 F P791 7.43x42 P791 7.43x42 P L792 7.44x43 L792 7.44x43 L P793 7.45x45 P793 7.45x45 P A794 7.46x46 A794 7.46x46 A C795 7.47x47 C795 7.47x47 C L796 7.48x48 L796 7.48x48 L N797 7.49x49 N797 7.49x49 N P798 7.50x50 P798 7.50x50 P V799 7.51x51 V799 7.51x51 V L800 7.52x52 L800 7.52x52 L Y801 7.53x53 Y801 7.53x53 Y V802 7.54x54 V802 7.54x54 V F803 7.55x55 F803 7.55x55 F F804 7.56x56 F804 7.56x56 F N805 8.47x47 N805 8.47x47 N P806 8.48x48 P806 8.48x48 P K807 8.49x49 K807 8.49x49 K W812 8.54x54 W812 8.54x54 W K813 8.55x55 K813 8.55x55 K L814 8.56x56 L814 8.56x56 L V819 8.61x61 V819 8.61x61 V F808 8.50x50 F808 8.50x50 F K809 8.51x51 K809 8.51x51 K E810 8.52x52 E810 8.52x52 E D811 8.53x53 D811 8.53x53 D L815 8.57x57 L815 8.57x57 L K816 8.58x58 K816 8.58x58 K R817 8.59x59 R817 8.59x59 R R818 8.60x60 R818 8.60x60 R

Top 100 conformational changes

Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.

Rank Residue 1 Residue 2 Active RRCS Inactive RRCS ΔRRCS Magnitude
1 HIS256 TYR280 7.010 20.499 -13.489 HIGH
2 ASN337 GLN340 12.492 0.786 +11.707 HIGH
3 ASN362 GLN386 13.851 3.431 +10.420 HIGH
4 GLU322 ARG346 0.000 10.135 -10.135 HIGH
5 GLU146 VAL170 9.411 0.000 +9.411 HIGH
6 ARG126 GLU150 0.000 9.232 -9.232 HIGH
7 GLN113 ARG135 0.000 9.194 -9.194 HIGH
8 ARG156 GLN180 0.000 9.089 -9.089 HIGH
9 ASN163 ASN187 0.000 9.087 -9.087 HIGH
10 ASN139 ASN163 0.000 8.936 -8.936 HIGH
11 THR329 ASN353 0.000 8.883 -8.883 HIGH
12 ASN233 HIS256 8.533 17.265 -8.732 HIGH
13 TYR378 GLN379 0.000 8.566 -8.566 HIGH
14 LEU165 ASN187 0.000 8.566 -8.566 HIGH
15 LEU315 LEU338 8.384 0.000 +8.384 HIGH
16 TRP159 LEU160 8.310 0.000 +8.310 HIGH
17 ARG304 ASP349 8.296 0.000 +8.296 HIGH
18 LEU295 GLN342 8.255 0.000 +8.255 HIGH
19 ILE141 ASN163 0.000 8.171 -8.171 HIGH
20 GLU642 (3.49x49) ARG643 (3.50x50) 0.115 8.171 -8.056 HIGH
21 LEU295 THR318 0.000 8.011 -8.011 HIGH
22 GLU497 LYS498 0.000 7.954 -7.954 HIGH
23 LEU131 THR178 7.880 0.000 +7.880 HIGH
24 GLN373 ASP395 2.047 9.872 -7.826 HIGH
25 GLU533 GLY603 0.000 7.754 -7.754 HIGH
26 TRP474 THR526 0.000 7.660 -7.660 HIGH
27 HIS748 (6.36x36) TYR801 (7.53x53) 0.000 7.484 -7.484 HIGH
28 PHE312 PRO359 7.198 0.000 +7.198 HIGH
29 ILE69 ASN91 1.113 8.207 -7.094 HIGH
30 LEU160 ASP161 6.985 0.000 +6.985 HIGH
31 ILE141 ASN187 6.949 0.000 +6.949 HIGH
32 ASP137 ASP161 0.000 6.807 -6.807 HIGH
33 ARG275 ASP297 3.448 10.234 -6.786 HIGH
34 GLU533 GLU780 (7.32x31) 6.774 0.000 +6.774 HIGH
35 ALA138 ASP162 0.000 6.725 -6.725 HIGH
36 HIS402 GLU424 8.516 1.934 +6.583 HIGH
37 ASP137 ALA185 6.493 0.000 +6.493 HIGH
38 ALA306 ASN353 6.473 0.000 +6.473 HIGH
39 HIS293 GLU341 6.427 0.000 +6.427 HIGH
40 THR327 SER351 0.000 6.350 -6.350 HIGH
41 ASN756 (6.44x44) ASN797 (7.49x49) 0.089 6.417 -6.328 HIGH
42 PHE759 (6.47x47) PRO793 (7.45x45) 7.282 1.136 +6.146 HIGH
43 ASN314 PRO335 6.130 0.000 +6.130 HIGH
44 LEU237 SER259 0.000 6.084 -6.084 HIGH
45 TYR352 GLN373 7.876 1.859 +6.018 HIGH
46 ASP357 TYR378 0.000 5.992 -5.992 HIGH
47 ARG304 SER351 5.738 0.000 +5.738 HIGH
48 LEU155 THR178 0.000 5.730 -5.730 HIGH
49 ASP161 THR183 0.000 5.651 -5.651 HIGH
50 SER122 ASP147 0.000 5.639 -5.639 HIGH
51 ARG135 TRP159 0.000 5.568 -5.568 HIGH
52 LEU165 LYS188 0.000 5.533 -5.533 HIGH
53 PRO798 (7.50x50) PHE803 (7.55x55) 5.531 0.000 +5.531 HIGH
54 TYR280 ARG304 5.524 0.000 +5.524 HIGH
55 HIS299 ARG346 5.507 0.000 +5.507 HIGH
56 PHE679 (4.59x59) PHE706 (5.39x39) 9.090 3.612 +5.478 HIGH
57 PHE529 PHE696 1.144 6.617 -5.473 HIGH
58 THR325 ASP349 0.000 5.461 -5.461 HIGH
59 LYS448 TRP611 9.863 4.430 +5.432 HIGH
60 ALA528 GLU780 (7.32x31) 0.000 5.428 -5.428 HIGH
61 GLN113 ASP137 4.806 10.203 -5.397 HIGH
62 ILE141 SER164 0.000 5.391 -5.391 HIGH
63 LEU134 TRP159 0.000 5.378 -5.378 HIGH
64 LEU131 LEU155 0.000 5.353 -5.353 HIGH
65 ASN233 GLY254 0.614 5.918 -5.304 HIGH
66 THR316 ASN337 5.287 0.000 +5.287 HIGH
67 ILE331 ASN354 0.000 5.223 -5.223 HIGH
68 ALA138 LEU186 5.142 0.000 +5.142 HIGH
69 ASP162 LEU186 0.000 5.140 -5.140 HIGH
70 ASP161 ALA185 0.000 5.125 -5.125 HIGH
71 HIS299 GLU322 0.000 5.104 -5.104 HIGH
72 SER478 ILE518 5.075 0.000 +5.075 HIGH
73 SER307 LYS330 0.000 4.994 -4.994 MED
74 VAL799 (7.51x51) PHE804 (7.56x56) 5.158 0.173 +4.985 MED
75 ASP63 GLN87 10.785 5.801 +4.983 MED
76 VAL302 ASP349 4.966 0.000 +4.966 MED
77 TRP812 (8.54x54) LYS816 (8.58x58) 0.000 4.916 -4.916 MED
78 ILE303 THR325 0.000 4.911 -4.911 MED
79 PHE312 PRO335 0.000 4.909 -4.909 MED
80 ILE141 LYS188 4.897 0.000 +4.897 MED
81 ASN211 ASN235 3.015 7.892 -4.877 MED
82 ASN258 ASN282 4.491 9.363 -4.872 MED
83 GLU533 TYR534 0.000 4.857 -4.857 MED
84 LEU298 LEU345 4.848 0.000 +4.848 MED
85 ALA528 LYS783 (7.35x34) 0.000 4.848 -4.848 MED
86 LEU136 TRP159 0.000 4.804 -4.804 MED
87 ARG156 LEU179 0.000 4.752 -4.752 MED
88 THR698 SER703 (5.36x36) 4.903 0.173 +4.730 MED
89 ASP649 (3.56x56) SER656 (34.56x56) 0.000 4.728 -4.728 MED
90 VAL309 ASN354 4.693 0.000 +4.693 MED
91 TYR729 (5.62x62) ILE746 (6.34x34) 5.317 0.630 +4.687 MED
92 ILE303 LEU350 4.660 0.000 +4.660 MED
93 VAL309 LYS330 0.000 4.658 -4.658 MED
94 ARG407 GLU431 1.785 6.433 -4.648 MED
95 TRP751 (6.39x39) LEU800 (7.52x52) 4.852 0.210 +4.641 MED
96 ILE377 ASN399 4.257 8.897 -4.640 MED
97 TYR801 (7.53x53) ASN805 (8.47x47) 0.000 4.601 -4.601 MED
98 PRO32 LYS46 0.000 4.588 -4.588 MED
99 VAL170 ALA196 0.000 4.559 -4.559 MED
100 GLY328 TYR352 0.000 4.558 -4.558 MED

Transmembrane domain analysis

Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.62 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).

Per-segment summary
Segment Range Active-favoring residues Count Inactive-favoring residues Count
TM1 539-566 539 (3.6), 540 (3.6), 566 (3.3), 555 (3.1) 4 542 (-4.0), 546 (-4.0) 2
TM2 572-602 598 (3.1) 1 573 (-3.8), 572 (-3.5), 602 (-3.2), 577 (-3.1) 4
TM3 630-649 640 (3.8), 636 (3.0) 2 642 (-8.1), 643 (-8.1), 649 (-4.7), 630 (-3.0) 4
TM4 658-679 679 (5.5) 1 658 (-4.3) 1
TM5 703-729 706 (5.5), 703 (4.7), 729 (4.7), 715 (4.3), 710 (4.2), 725 (3.8) 6 718 (-4.2) 1
TM6 741-760 759 (6.1), 746 (4.7), 751 (4.6), 760 (4.3), 742 (4.1) 5 748 (-7.5), 756 (-6.3), 743 (-4.2), 741 (-4.1), 752 (-4.0), 750 (-3.6), 753 (-3.0) 7
TM7 779-804 780 (6.8), 793 (6.1), 798 (5.5), 803 (5.5), 799 (5.0), 804 (5.0), 800 (4.6) 7 801 (-7.5), 797 (-6.3), 783 (-4.8), 789 (-3.9), 779 (-3.7) 5
Intracellular / Extracellular loops & H8
ICL1 - - 0 - 0
ICL2 654-656 - 0 656 (-4.7), 654 (-4.0) 2
ICL3 737-737 - 0 737 (-4.2) 1
ECL1 603-611 611 (5.4) 1 603 (-7.8), 609 (-4.2), 605 (-3.9), 606 (-3.5) 4
ECL2 686-698 698 (4.7), 686 (4.4) 2 696 (-5.5) 1
ECL3 - - 0 - 0
H8 805-816 811 (3.3) 1 812 (-4.9), 816 (-4.9), 805 (-4.6), 807 (-4.1), 808 (-3.6) 5

Interactive visualizations

ΔRRCS distribution

Active vs inactive comparison

Residue-wise changes

TM domain breakdown

Variants of interest

305 variants mapped to contact positions, sorted by |ΔRRCS| impact.

Position Protein change DNA change Allele freq Het / Hom ΔRRCS AM score Pathogenicity Conservation dbSNP
256 p.His256Arg c.767A>G 2.19e-06 3 / 0 13.49 0.896 PATHOGENIC 0.64
256 p.His256Leu c.767A>T 7.29e-07 1 / 0 13.49 - nan - rs1332011712
256 p.His256Asp c.766C>G 6.57e-06 1 / 0 13.49 - nan - rs1458880615
362 p.Asn362Asp c.1084A>G 6.94e-07 1 / 0 10.42 0.065 BENIGN 0.40
346 p.Arg346Ser c.1038G>C 1.38e-06 2 / 0 10.14 0.665 PATHOGENIC 0.53 rs1296666966
322 p.Glu322Gly c.965A>G 4.81e-06 7 / 0 10.14 0.628 PATHOGENIC 0.71 rs1863066644
346 p.Arg346Thr c.1037G>C 5.51e-06 8 / 0 10.14 - nan - rs538854301
170 p.Val170Met c.508G>A 1.37e-06 2 / 0 9.41 0.117 BENIGN 0.64 rs751940116
146 p.Glu146Lys c.436G>A 1.03e-05 15 / 0 9.41 0.069 BENIGN 0.51 rs769421305
170 p.Val170Leu c.508G>T 3.42e-06 5 / 0 9.41 - nan - rs751940116
126 p.Arg126Gln c.377G>A 1.10e-05 16 / 0 9.23 0.073 BENIGN 0.49 rs568680202
126 p.Arg126Pro c.377G>C 2.06e-06 3 / 0 9.23 - nan - rs568680202
135 p.Arg135His c.404G>A 1.39e-06 2 / 0 9.19 0.413 AMBIGUOUS 0.76 rs183096316
135 p.Arg135Cys c.403C>T 6.95e-07 1 / 0 9.19 - nan - rs1314460232
156 p.Arg156Gln c.467G>A 1.09e-03 1552 / 20 9.09 0.285 BENIGN 0.77 rs143913282
156 p.Arg156Trp c.466C>T 1.58e-05 23 / 0 9.09 - nan - rs749587915
187 p.Asn187Lys c.561C>G 6.88e-07 1 / 0 9.09 0.998 PATHOGENIC 0.93
163 p.Asn163Ser c.488A>G 1.37e-06 2 / 0 9.09 0.872 PATHOGENIC 0.96
163 p.Asn163Thr c.488A>C 6.85e-07 1 / 0 9.09 - nan - rs1863168169
139 p.Asn139Ser c.416A>G 1.38e-06 2 / 0 8.94 0.814 PATHOGENIC 0.95 rs1863170584
139 p.Asn139Asp c.415A>G 6.89e-07 1 / 0 8.94 - nan -
353 p.Asn353Ser c.1058A>G 2.14e-06 3 / 0 8.88 0.729 PATHOGENIC 0.88 rs1194018717
329 p.Thr329Ala c.985A>G 5.48e-06 8 / 0 8.88 0.183 BENIGN 0.53 rs371742671
353 p.Asn353Asp c.1057A>G 7.11e-07 1 / 0 8.88 - nan -
379 p.Gln379His c.1137A>C 6.58e-06 1 / 0 8.57 0.134 BENIGN 0.53 rs1376065791
379 p.Gln379Lys c.1135C>A 7.04e-07 1 / 0 8.57 - nan -
165 p.Leu165Phe c.495G>T 1.37e-06 2 / 0 8.57 0.622 PATHOGENIC 0.90
338 p.Leu338Val c.1012T>G 6.85e-07 1 / 0 8.38 0.110 BENIGN 0.53
349 p.Asp349Glu c.1047C>A 7.29e-07 1 / 0 8.30 0.722 PATHOGENIC 0.62
304 p.Arg304His c.911G>A 2.06e-05 30 / 0 8.30 0.425 AMBIGUOUS 0.52 rs780334452
304 p.Arg304Cys c.910C>T 4.81e-06 7 / 0 8.30 - nan - rs200212084
342 p.Gln342Lys c.1024C>A 6.85e-07 1 / 0 8.26 0.204 BENIGN 0.47
141 p.Ile141Thr c.422T>C 6.88e-07 1 / 0 8.17 0.991 PATHOGENIC 0.84
643 p.Arg643Ser c.1929A>C 2.46e-05 34 / 1 8.06 0.874 PATHOGENIC 0.82 rs773307093
642 p.Glu642Gly c.1925A>G 6.84e-07 1 / 0 8.06 0.763 PATHOGENIC 0.84
642 p.Glu642Lys c.1924G>A 9.30e-05 136 / 0 8.06 - nan - rs150703196
318 p.Thr318Ile c.953C>T 1.65e-05 24 / 0 8.01 0.790 PATHOGENIC 0.68 rs1464796752
318 p.Thr318Ala c.952A>G 8.91e-06 13 / 0 8.01 - nan - rs761102295
497 p.Glu497Asp c.1491G>T 6.57e-06 1 / 0 7.95 0.074 BENIGN 0.36 rs1565068864
131 p.Leu131Val c.391T>G 6.89e-07 1 / 0 7.88 0.344 AMBIGUOUS 0.95 rs747930921
178 p.Thr178Ile c.533C>T 1.37e-06 2 / 0 7.88 0.197 BENIGN 0.48 rs1169006445
178 p.Thr178Asn c.533C>A 6.85e-07 1 / 0 7.88 - nan -
178 p.Thr178Ala c.532A>G 6.85e-07 1 / 0 7.88 - nan -
395 p.Asp395His c.1183G>C 6.89e-07 1 / 0 7.83 0.909 PATHOGENIC 0.60 rs1279376863
603 p.Gly603Ala c.1808G>C 6.84e-07 1 / 0 7.75 0.676 PATHOGENIC 0.84
603 p.Gly603Ser c.1807G>A 6.58e-06 1 / 0 7.75 - nan - rs377568358
526 p.Thr526Ile c.1577C>T 6.87e-07 1 / 0 7.66 0.237 BENIGN 0.64
474 p.Trp474Leu c.1421G>T 6.57e-06 1 / 0 7.66 0.188 BENIGN 0.39 rs1387079528
526 p.Thr526Arg c.1577C>G 6.87e-07 1 / 0 7.66 - nan - rs1284806866
748 p.His748Gln c.2244T>A 6.84e-07 1 / 0 7.48 0.939 PATHOGENIC 0.78 rs2133357755
801 p.Tyr801Cys c.2402A>G 4.10e-06 6 / 0 7.48 0.783 PATHOGENIC 0.99
359 p.Pro359Leu c.1076C>T 6.97e-07 1 / 0 7.20 0.327 BENIGN 0.75
91 p.Asn91Lys c.273C>G 2.10e-06 3 / 0 7.09 0.998 PATHOGENIC 0.82 rs370663209
69 p.Ile69Val c.205A>G 1.38e-06 2 / 0 7.09 0.211 BENIGN 0.75 rs1253123496
91 p.Asn91Asp c.271A>G 1.39e-06 2 / 0 7.09 - nan - rs1390733403
161 p.Asp161Glu c.483T>A 6.57e-06 1 / 0 6.98 0.981 PATHOGENIC 0.74 rs559583578
137 p.Asp137Glu c.411T>A 6.90e-07 1 / 0 6.81 0.980 PATHOGENIC 0.77
137 p.Asp137Gly c.410A>G 6.90e-07 1 / 0 6.81 - nan - rs1863170701
137 p.Asp137His c.409G>C 6.91e-07 1 / 0 6.81 - nan - rs1381267350
297 p.Asp297Gly c.890A>G 7.02e-07 1 / 0 6.79 0.268 BENIGN 0.49 rs1484342153
297 p.Asp297Asn c.889G>A 7.01e-07 1 / 0 6.79 - nan - rs1219046482
780 p.Glu780Lys c.2338G>A 4.79e-06 7 / 0 6.77 0.723 PATHOGENIC 0.76 rs775198460
162 p.Asp162Glu c.486C>G 6.57e-06 1 / 0 6.73 0.962 PATHOGENIC 0.76 rs993690712
138 p.Ala138Asp c.413C>A 1.31e-05 19 / 0 6.73 0.951 PATHOGENIC 0.76 rs536355546
162 p.Asp162Val c.485A>T 6.85e-07 1 / 0 6.73 - nan -
162 p.Asp162Gly c.485A>G 6.85e-07 1 / 0 6.73 - nan -
424 p.Glu424Lys c.1270G>A 7.01e-07 1 / 0 6.58 0.086 BENIGN 0.42
402 p.His402Gln c.1206T>G 6.85e-07 1 / 0 6.58 0.086 BENIGN 0.37 rs761998521
402 p.His402Tyr c.1204C>T 1.37e-06 2 / 0 6.58 - nan -
402 p.His402Asn c.1204C>A 6.85e-07 1 / 0 6.58 - nan -
341 p.Glu341Lys c.1021G>A 6.85e-07 1 / 0 6.43 0.095 BENIGN 0.43
293 p.His293Gln c.879C>G 6.92e-07 1 / 0 6.43 0.077 BENIGN 0.54
351 p.Ser351Thr c.1051T>A 6.48e-06 9 / 0 6.35 0.648 PATHOGENIC 0.62 rs1863001204
327 p.Thr327Ala c.979A>G 7.25e-04 1056 / 0 6.35 0.442 AMBIGUOUS 0.53 rs75496259
327 p.Thr327Pro c.979A>C 6.86e-07 1 / 0 6.35 - nan -
756 p.Asn756Ser c.2267A>G 1.37e-06 2 / 0 6.33 0.353 AMBIGUOUS 0.75 rs753024425
793 p.Pro793Thr c.2377C>A 6.84e-07 1 / 0 6.15 0.723 PATHOGENIC 0.70
793 p.Pro793Ser c.2377C>T 6.84e-07 1 / 0 6.15 - nan - rs1392733766
335 p.Pro335Ser c.1003C>T 2.74e-06 4 / 0 6.13 0.137 BENIGN 0.76 rs370470269
314 p.Asn314Ser c.941A>G 6.17e-06 9 / 0 6.13 0.078 BENIGN 0.58 rs375937843
314 p.Asn314Asp c.940A>G 6.85e-07 1 / 0 6.13 - nan - rs762186717
237 p.Leu237Phe c.711G>T 6.87e-07 1 / 0 6.08 0.383 AMBIGUOUS 0.71
259 p.Ser259Phe c.776C>T 7.24e-07 1 / 0 6.08 0.101 BENIGN 0.47
237 p.Leu237Val c.709T>G 6.87e-07 1 / 0 6.08 - nan -
357 p.Asp357Glu c.1071C>A 6.99e-07 1 / 0 5.99 0.084 BENIGN 0.47
183 p.Thr183Ala c.547A>G 6.18e-06 9 / 0 5.65 0.916 PATHOGENIC 0.70 rs745810561
147 p.Asp147Val c.440A>T 6.86e-07 1 / 0 5.64 0.142 BENIGN 0.48 rs530261420
122 p.Ser122Asn c.365G>A 6.86e-07 1 / 0 5.64 0.082 BENIGN 0.46
147 p.Asp147Tyr c.439G>T 6.86e-07 1 / 0 5.64 - nan - rs548402677
122 p.Ser122Arg c.364A>C 1.37e-06 2 / 0 5.64 - nan - rs1019972222
798 p.Pro798Ala c.2392C>G 1.37e-06 2 / 0 5.53 0.902 PATHOGENIC 0.99 rs1351793855
803 p.Phe803Ser c.2408T>C 2.26e-05 33 / 0 5.53 0.746 PATHOGENIC 0.61 rs755269708
299 p.His299Asp c.895C>G 7.06e-07 1 / 0 5.51 0.478 AMBIGUOUS 0.53
299 p.His299Asn c.895C>A 7.06e-07 1 / 0 5.51 - nan -
679 p.Phe679Val c.2035T>G 6.84e-07 1 / 0 5.48 0.070 BENIGN 0.65
529 p.Phe529Leu c.1587T>A 4.90e-06 7 / 0 5.47 0.981 PATHOGENIC 0.96 rs1293512133
448 p.Lys448Asn c.1344A>C 6.23e-06 9 / 0 5.43 0.622 PATHOGENIC 0.50 rs1442384003
611 p.Trp611Arg c.1831T>C 2.05e-06 3 / 0 5.43 0.230 BENIGN 0.44 rs773360974
611 p.Trp611Gly c.1831T>G 6.84e-07 1 / 0 5.43 - nan -
448 p.Lys448Glu c.1342A>G 6.92e-07 1 / 0 5.43 - nan -
528 p.Ala528Val c.1583C>T 2.10e-06 3 / 0 5.43 0.502 AMBIGUOUS 0.68 rs1370470333
528 p.Ala528Asp c.1583C>A 2.10e-06 3 / 0 5.43 - nan - rs1370470333
528 p.Ala528Ser c.1582G>T 2.11e-06 3 / 0 5.43 - nan - rs1462249348
164 p.Ser164Asn c.491G>A 6.85e-07 1 / 0 5.39 0.095 BENIGN 0.49
134 p.Leu134Ser c.401T>C 6.95e-07 1 / 0 5.38 0.995 PATHOGENIC 0.97
316 p.Thr316Lys c.947C>A 6.86e-07 1 / 0 5.29 0.093 BENIGN 0.55 rs558229406
316 p.Thr316Ala c.946A>G 3.43e-06 5 / 0 5.29 - nan - rs754184739
354 p.Asn354Ser c.1061A>G 7.07e-07 1 / 0 5.22 0.076 BENIGN 0.40 rs1476182391
186 p.Leu186Val c.556C>G 4.81e-06 7 / 0 5.14 0.610 PATHOGENIC 0.71 rs1478422675
478 p.Ser478Cys c.1433C>G 6.84e-07 1 / 0 5.07 0.367 AMBIGUOUS 0.60 rs768283736
518 p.Ile518Leu c.1552A>C 6.84e-07 1 / 0 5.07 0.081 BENIGN 0.38
478 p.Ser478Phe c.1433C>T 6.84e-07 1 / 0 5.07 - nan - rs768283736
330 p.Lys330Asn c.990G>T 6.85e-07 1 / 0 4.99 0.318 BENIGN 0.45
330 p.Lys330Glu c.988A>G 5.48e-06 8 / 0 4.99 - nan - rs770556748
330 p.Lys330Gln c.988A>C 6.85e-07 1 / 0 4.99 - nan - rs770556748
799 p.Val799Ile c.2395G>A 6.84e-07 1 / 0 4.99 0.111 BENIGN 0.62
63 p.Asp63Ala c.188A>C 6.57e-06 1 / 0 4.98 0.713 PATHOGENIC 0.70 rs1480966678
87 p.Gln87Arg c.260A>G 7.10e-07 1 / 0 4.98 0.076 BENIGN 0.56 rs1382941841
87 p.Gln87Lys c.259C>A 4.43e-06 6 / 0 4.98 - nan -
63 p.Asp63Gly c.188A>G 4.16e-06 6 / 0 4.98 - nan - rs1480966678
63 p.Asp63Tyr c.187G>T 2.08e-06 3 / 0 4.98 - nan - rs1248687899
63 p.Asp63Asn c.187G>A 1.39e-06 2 / 0 4.98 - nan -
302 p.Val302Leu c.904G>C 5.51e-06 8 / 0 4.97 0.340 BENIGN 0.41 rs2133368723
302 p.Val302Phe c.904G>T 6.88e-07 1 / 0 4.97 - nan -
812 p.Trp812Cys c.2436G>C 6.84e-07 1 / 0 4.92 0.728 PATHOGENIC 0.49 rs1489277706
816 p.Lys816Glu c.2446A>G 6.57e-06 1 / 0 4.92 0.232 BENIGN 0.45 rs1407541151
303 p.Ile303Thr c.908T>C 2.07e-06 3 / 0 4.91 0.971 PATHOGENIC 0.68 rs756007479
303 p.Ile303Val c.907A>G 4.13e-06 6 / 0 4.91 - nan -
211 p.Asn211Ser c.632A>G 6.86e-07 1 / 0 4.88 0.919 PATHOGENIC 0.88 rs1246815630
235 p.Asn235Ser c.704A>G 6.88e-07 1 / 0 4.88 0.775 PATHOGENIC 0.91
211 p.Asn211Asp c.631A>G 2.06e-06 3 / 0 4.88 - nan - rs779240485
258 p.Asn258Lys c.774T>A 7.23e-07 1 / 0 4.87 0.998 PATHOGENIC 0.88
282 p.Asn282Ser c.845A>G 6.90e-07 1 / 0 4.87 0.913 PATHOGENIC 0.89
258 p.Asn258Ser c.773A>G 7.22e-07 1 / 0 4.87 - nan - rs1403714885
298 p.Leu298Phe c.892C>T 7.03e-07 1 / 0 4.85 0.957 PATHOGENIC 0.87 rs1277504427
783 p.Lys783Arg c.2348A>G 2.05e-06 3 / 0 4.85 0.334 BENIGN 0.99 rs772014305
136 p.Leu136Ser c.407T>C 6.91e-07 1 / 0 4.80 0.996 PATHOGENIC 0.97
179 p.Leu179Gln c.536T>A 6.85e-07 1 / 0 4.75 0.984 PATHOGENIC 0.95
703 p.Ser703Pro c.2107T>C 5.47e-06 8 / 0 4.73 0.141 BENIGN 0.65 rs1404076351
656 p.Ser656Asn c.1967G>A 2.63e-05 4 / 0 4.73 0.085 BENIGN 0.49 rs981837753
649 p.Asp649Glu c.1947T>G 1.37e-06 2 / 0 4.73 0.081 BENIGN 0.35
649 p.Asp649Asn c.1945G>A 2.05e-06 3 / 0 4.73 - nan -
746 p.Ile746Asn c.2237T>A 6.84e-07 1 / 0 4.69 0.659 PATHOGENIC 0.59
729 p.Tyr729Cys c.2186A>G 1.37e-06 2 / 0 4.69 0.648 PATHOGENIC 0.98
746 p.Ile746Thr c.2237T>C 1.37e-06 2 / 0 4.69 - nan - rs758290426
746 p.Ile746Phe c.2236A>T 6.84e-06 10 / 0 4.69 - nan - rs1862811961
746 p.Ile746Val c.2236A>G 1.37e-06 2 / 0 4.69 - nan -
729 p.Tyr729His c.2185T>C 1.37e-06 2 / 0 4.69 - nan - rs768385937
729 p.Tyr729Asn c.2185T>A 6.84e-07 1 / 0 4.69 - nan -
431 p.Glu431Lys c.1291G>A 1.39e-06 2 / 0 4.65 0.086 BENIGN 0.39 rs777443017
407 p.Arg407Gly c.1219A>G 5.48e-06 8 / 0 4.65 0.062 BENIGN 0.38 rs1233701317
800 p.Leu800Pro c.2399T>C 6.84e-07 1 / 0 4.64 0.992 PATHOGENIC 1.00
800 p.Leu800Val c.2398C>G 3.42e-06 5 / 0 4.64 - nan -
377 p.Ile377Met c.1131C>G 2.12e-06 3 / 0 4.64 0.317 BENIGN 0.79
805 p.Asn805Lys c.2415C>A 2.74e-06 4 / 0 4.60 0.943 PATHOGENIC 0.67 rs1252159538
805 p.Asn805His c.2413A>C 6.84e-07 1 / 0 4.60 - nan -
46 p.Lys46Asn c.138G>C 7.91e-07 1 / 0 4.59 0.432 AMBIGUOUS 0.45
32 p.Pro32Leu c.95C>T 1.61e-06 2 / 0 4.59 0.124 BENIGN 0.43 rs1452952330
46 p.Lys46Arg c.137A>G 8.49e-07 1 / 0 4.59 - nan -
46 p.Lys46Thr c.137A>C 8.49e-07 1 / 0 4.59 - nan -
46 p.Lys46Glu c.136A>G 9.18e-07 1 / 0 4.59 - nan -
32 p.Pro32Thr c.94C>A 2.44e-06 3 / 0 4.59 - nan -
32 p.Pro32Ser c.94C>T 2.44e-06 3 / 0 4.59 - nan -
232 p.Leu232Val c.694T>G 3.45e-06 5 / 0 4.55 0.378 AMBIGUOUS 0.83 rs1474383258
308 p.Met308Ile c.924G>A 1.37e-06 2 / 0 4.53 0.387 AMBIGUOUS 0.38 rs1330154221
308 p.Met308Val c.922A>G 2.74e-06 4 / 0 4.53 - nan - rs374994542
321 p.Leu321Val c.961C>G 6.57e-06 1 / 0 4.52 0.410 AMBIGUOUS 0.92 rs1458708142
210 p.Asn210His c.628A>C 2.06e-06 3 / 0 4.50 0.447 AMBIGUOUS 0.71 rs1279169767
398 p.Arg398Lys c.1193G>A 6.86e-07 1 / 0 4.50 0.123 BENIGN 0.37 rs773272289
374 p.Arg374His c.1121G>A 2.05e-04 282 / 1 4.50 0.063 BENIGN 0.47 rs371443871
398 p.Arg398Gly c.1192A>G 6.86e-07 1 / 0 4.50 - nan -
374 p.Arg374Leu c.1121G>T 7.20e-07 1 / 0 4.50 - nan - rs371443871
374 p.Arg374Cys c.1120C>T 2.60e-05 36 / 0 4.50 - nan - rs140395327
344 p.Met344Leu c.1030A>C 6.86e-07 1 / 0 4.49 0.085 BENIGN 0.32
344 p.Met344Leu c.1030A>T 1.37e-06 2 / 0 4.49 - nan -
132 p.Gln132Arg c.395A>G 6.57e-06 1 / 0 4.48 0.186 BENIGN 0.69 rs1459535651
154 p.Gln154Lys c.460C>A 2.06e-06 3 / 0 4.48 0.149 BENIGN 0.51 rs1403005545
277 p.Ile277Thr c.830T>C 3.66e-06 5 / 0 4.47 0.948 PATHOGENIC 0.70 rs757191638
277 p.Ile277Val c.829A>G 2.93e-06 4 / 0 4.47 - nan - rs143341718
305 p.Gly305Asp c.914G>A 6.86e-07 1 / 0 4.46 0.951 PATHOGENIC 0.65
305 p.Gly305Ser c.913G>A 6.86e-07 1 / 0 4.46 - nan -
339 p.Cys339Tyr c.1016G>A 1.37e-06 2 / 0 4.45 0.976 PATHOGENIC 0.61 rs1240276307
361 p.Phe361Cys c.1082T>G 6.94e-07 1 / 0 4.45 0.812 PATHOGENIC 0.79 rs1216062587
686 p.Glu686Gly c.2057A>G 6.84e-06 10 / 0 4.36 0.108 BENIGN 0.55 rs1407876071
686 p.Glu686Lys c.2056G>A 2.67e-05 39 / 0 4.36 - nan - rs772683855
10 p.Phe10Tyr c.29T>A 3.61e-06 4 / 0 4.33 0.208 BENIGN 0.52
10 p.Phe10Leu c.28T>C 2.26e-05 25 / 0 4.33 - nan - rs1288238177
715 p.Ser715Leu c.2144C>T 6.86e-07 1 / 0 4.31 0.257 BENIGN 0.60 rs1329094630
715 p.Ser715Pro c.2143T>C 6.84e-07 1 / 0 4.31 - nan - rs1353585591
895 p.Tyr895Cys c.2684A>G 1.38e-06 2 / 0 4.30 0.096 BENIGN 0.81
278 p.His278Tyr c.832C>T 1.39e-06 2 / 0 4.25 0.239 BENIGN 0.55 rs779631815
300 p.Ser300Phe c.899C>T 2.85e-06 4 / 0 4.25 0.360 AMBIGUOUS 0.46
276 p.Thr276Ser c.827C>G 1.02e-05 14 / 0 4.25 0.182 BENIGN 0.55 rs1310068048
276 p.Thr276Ala c.826A>G 7.27e-07 1 / 0 4.25 - nan - rs1376342880
92 p.Asp92Gly c.275A>G 1.39e-06 2 / 0 4.25 0.338 BENIGN 0.44 rs1863304030
116 p.Gln116His c.348G>C 1.37e-06 2 / 0 4.25 0.265 BENIGN 0.70 rs149706958
116 p.Gln116His c.348G>T 6.87e-07 1 / 0 4.25 - nan -
116 p.Gln116Leu c.347A>T 6.88e-07 1 / 0 4.25 - nan - rs961908195
116 p.Gln116Arg c.347A>G 6.58e-06 1 / 0 4.25 - nan - rs961908195
92 p.Asp92Asn c.274G>A 2.80e-06 4 / 0 4.25 - nan - rs376236224
296 p.Ser296Tyr c.887C>A 6.99e-07 1 / 0 4.23 0.258 BENIGN 0.56
320 p.His320Gln c.960C>G 6.87e-07 1 / 0 4.23 0.096 BENIGN 0.47 rs1199783981
320 p.His320Asp c.958C>G 2.06e-06 3 / 0 4.23 - nan - rs1456342449
718 p.Phe718Leu c.2152T>C 6.85e-07 1 / 0 4.23 0.986 PATHOGENIC 0.89
743 p.Ser743Cys c.2228C>G 1.37e-06 2 / 0 4.19 0.100 BENIGN 0.48 rs780003296
609 p.Gly609Asp c.1826G>A 6.84e-07 1 / 0 4.17 0.993 PATHOGENIC 0.79 rs1383595331
269 p.Asp269Gly c.806A>G 1.14e-05 16 / 0 4.16 0.074 BENIGN 0.33 rs1863081019
245 p.Lys245Arg c.734A>G 6.86e-07 1 / 0 4.16 0.071 BENIGN 0.54
710 p.Leu710Ser c.2129T>C 6.57e-06 1 / 0 4.16 0.753 PATHOGENIC 0.86 rs1307336368
301 p.Leu301Arg c.902T>G 1.43e-06 2 / 0 4.12 0.993 PATHOGENIC 0.78
807 p.Lys807Asn c.2421G>T 6.84e-07 1 / 0 4.11 0.331 BENIGN 0.43 rs766724360
742 p.Gln742Leu c.2225A>T 6.84e-07 1 / 0 4.07 0.147 BENIGN 0.57
742 p.Gln742Pro c.2225A>C 6.84e-07 1 / 0 4.07 - nan -
742 p.Gln742Lys c.2224C>A 1.37e-06 2 / 0 4.07 - nan -
140 p.His140Arg c.419A>G 2.07e-06 3 / 0 4.07 0.127 BENIGN 0.55
326 p.Leu326Ser c.977T>C 6.86e-07 1 / 0 4.04 0.960 PATHOGENIC 0.68
279 p.Leu279Phe c.837G>T 6.57e-06 1 / 0 4.03 0.190 BENIGN 0.63
752 p.Leu752Val c.2254C>G 6.84e-07 1 / 0 4.00 0.620 PATHOGENIC 0.99 rs1862811323
157 p.His157Arg c.470A>G 1.37e-06 2 / 0 4.00 0.911 PATHOGENIC 0.80 rs772158015
654 p.Gly654Glu c.1961G>A 6.84e-07 1 / 0 3.99 0.122 BENIGN 0.62
654 p.Gly654Arg c.1960G>A 6.84e-07 1 / 0 3.99 - nan - rs1405683740
542 p.Arg542His c.1625G>A 2.95e-05 43 / 0 3.98 0.919 PATHOGENIC 0.99 rs200626048
542 p.Arg542Pro c.1625G>C 6.85e-07 1 / 0 3.98 - nan -
542 p.Arg542Leu c.1625G>T 2.74e-06 4 / 0 3.98 - nan - rs200626048
542 p.Arg542Cys c.1624C>T 6.86e-07 1 / 0 3.98 - nan - rs1862832608
347 p.Thr347Ile c.1040C>T 1.38e-06 2 / 0 3.98 0.207 BENIGN 0.44 rs1358902317
347 p.Thr347Ser c.1039A>T 6.90e-07 1 / 0 3.98 - nan - rs1416944136
347 p.Thr347Ala c.1039A>G 2.07e-06 3 / 0 3.98 - nan - rs1416944136
88 p.Leu88Phe c.264G>T 7.12e-07 1 / 0 3.95 0.712 PATHOGENIC 0.79
88 p.Leu88Val c.262T>G 7.07e-07 1 / 0 3.95 - nan -
789 p.Phe789Leu c.2365T>C 1.37e-06 2 / 0 3.94 0.936 PATHOGENIC 0.66
289 p.Asn289His c.865A>C 6.89e-07 1 / 0 3.93 0.076 BENIGN 0.41
260 p.Ile260Met c.780T>G 7.20e-07 1 / 0 3.89 0.639 PATHOGENIC 0.82
323 p.Ser323Arg c.969T>A 3.44e-05 50 / 0 3.85 0.923 PATHOGENIC 0.53 rs575879732
323 p.Ser323Ile c.968G>T 6.88e-07 1 / 0 3.85 - nan -
323 p.Ser323Asn c.968G>A 1.31e-05 2 / 0 3.85 - nan - rs546206909
323 p.Ser323Thr c.968G>C 1.38e-06 2 / 0 3.85 - nan -
323 p.Ser323Cys c.967A>T 1.38e-06 2 / 0 3.85 - nan - rs774968337
725 p.Tyr725His c.2173T>C 1.37e-06 2 / 0 3.84 0.916 PATHOGENIC 1.00
640 p.Thr640Ala c.1918A>G 2.74e-06 4 / 0 3.84 0.047 BENIGN 0.71 rs755999472
209 p.His209Gln c.627T>A 2.75e-06 4 / 0 3.75 0.878 PATHOGENIC 0.66
209 p.His209Arg c.626A>G 4.12e-06 6 / 0 3.75 - nan - rs746365357
906 p.Ser906Phe c.2717C>T 6.57e-06 1 / 0 3.72 0.631 PATHOGENIC 0.87 rs747119729
906 p.Ser906Tyr c.2717C>A 1.31e-05 2 / 0 3.72 - nan - rs747119729
779 p.Pro779Ala c.2335C>G 6.84e-07 1 / 0 3.67 0.308 BENIGN 0.67 rs746758068
421 p.Ser421Gly c.1261A>G 6.76e-05 94 / 1 3.61 0.417 AMBIGUOUS 0.66 rs552191763
129 p.Ser129Gly c.385A>G 6.87e-07 1 / 0 3.60 0.069 BENIGN 0.43
540 p.Met540Val c.1618A>G 6.10e-05 89 / 0 3.59 0.537 AMBIGUOUS 0.54 rs778459302
750 p.Ala750Ser c.2248G>T 1.37e-06 2 / 0 3.57 0.377 AMBIGUOUS 0.95
750 p.Ala750Thr c.2248G>A 3.21e-04 465 / 2 3.57 - nan - rs149204548
355 p.Ile355Leu c.1063A>C 7.05e-07 1 / 0 3.55 0.180 BENIGN 0.82
355 p.Ile355Val c.1063A>G 7.05e-07 1 / 0 3.55 - nan - rs1220191630
606 p.Ala606Gly c.1817C>G 5.47e-06 8 / 0 3.53 0.144 BENIGN 0.52 rs1862828458
606 p.Ala606Pro c.1816G>C 6.84e-07 1 / 0 3.53 - nan - rs760715826
606 p.Ala606Thr c.1816G>A 1.44e-05 21 / 0 3.53 - nan - rs760715826
189 p.Ile189Val c.565A>G 6.88e-07 1 / 0 3.51 0.348 AMBIGUOUS 0.87
166 p.Thr166Met c.497C>T 1.37e-05 20 / 0 3.51 0.078 BENIGN 0.81 rs901907532
189 p.Ile189Phe c.565A>T 6.88e-07 1 / 0 3.51 - nan - rs1863164974
44 p.Ser44Tyr c.131C>A 3.20e-06 4 / 0 3.51 0.550 AMBIGUOUS 0.65 rs1864889563
44 p.Ser44Pro c.130T>C 1.70e-06 2 / 0 3.51 - nan -
517 p.Gln517Glu c.1549C>G 6.84e-07 1 / 0 3.50 0.081 BENIGN 0.51 rs1471331772
481 p.Asn481His c.1441A>C 6.84e-07 1 / 0 3.50 0.063 BENIGN 0.47
481 p.Asn481Asp c.1441A>G 2.05e-06 3 / 0 3.50 - nan - rs1244635679
85 p.Glu85Gly c.254A>G 1.43e-06 2 / 0 3.49 0.406 AMBIGUOUS 0.59 rs1379922921
133 p.Ser133Tyr c.398C>A 1.39e-06 2 / 0 3.49 0.728 PATHOGENIC 0.70
181 p.Ala181Gly c.542C>G 1.37e-06 2 / 0 3.49 0.680 PATHOGENIC 0.74
181 p.Ala181Val c.542C>T 4.59e-05 67 / 0 3.49 - nan - rs775456873
181 p.Ala181Thr c.541G>A 6.85e-07 1 / 0 3.49 - nan -
348 p.Leu348Ser c.1043T>C 6.91e-07 1 / 0 3.49 0.978 PATHOGENIC 0.83
572 p.Ser572Leu c.1715C>T 8.21e-06 12 / 0 3.48 0.179 BENIGN 0.52 rs761830490
212 p.Lys212Asn c.636A>T 6.86e-07 1 / 0 3.46 0.331 BENIGN 0.58
153 p.Val153Ile c.457G>A 2.74e-06 4 / 0 3.36 0.069 BENIGN 0.36 rs1863169416
115 p.Asn115Ser c.344A>G 6.88e-07 1 / 0 3.35 0.893 PATHOGENIC 0.90
93 p.Leu93Phe c.277C>T 2.09e-06 3 / 0 3.35 0.666 PATHOGENIC 0.69 rs1401684189
115 p.Asn115Tyr c.343A>T 6.91e-07 1 / 0 3.35 - nan -
310 p.Gln310Arg c.929A>G 6.17e-06 9 / 0 3.35 0.074 BENIGN 0.50 rs750714025
811 p.Asp811Asn c.2431G>A 4.79e-06 7 / 0 3.29 0.741 PATHOGENIC 0.91 rs1445078206
566 p.Ser566Thr c.1696T>A 6.84e-07 1 / 0 3.29 0.099 BENIGN 0.74
285 p.Ser285Phe c.854C>T 6.89e-07 1 / 0 3.26 0.192 BENIGN 0.47
111 p.Thr111Met c.332C>T 3.42e-05 49 / 0 3.22 0.103 BENIGN 0.45 rs750458681
111 p.Thr111Ala c.331A>G 1.32e-05 2 / 0 3.22 - nan - rs557754522
172 p.Pro172Thr c.514C>A 1.37e-06 2 / 0 3.22 0.178 BENIGN 0.58
602 p.Trp602Ser c.1805G>C 2.74e-06 4 / 0 3.18 0.552 AMBIGUOUS 0.45 rs761634295
577 p.Ile577Thr c.1730T>C 1.37e-06 2 / 0 3.13 0.122 BENIGN 0.70
292 p.Phe292Cys c.875T>G 6.90e-07 1 / 0 3.12 0.995 PATHOGENIC 0.90
292 p.Phe292Ile c.874T>A 6.57e-06 1 / 0 3.12 - nan - rs1228088722
598 p.Asp598Glu c.1794T>A 2.05e-06 3 / 0 3.12 0.986 PATHOGENIC 0.95 rs12291757
598 p.Asp598Gly c.1793A>G 6.84e-07 1 / 0 3.12 - nan -
149 p.Phe149Ser c.446T>C 6.85e-07 1 / 0 3.08 0.981 PATHOGENIC 0.90
176 p.Leu176Val c.526C>G 1.37e-06 2 / 0 3.08 0.234 BENIGN 0.79
89 p.Ala89Val c.266C>T 4.24e-06 6 / 0 3.08 0.688 PATHOGENIC 0.53 rs1863304355
89 p.Ala89Pro c.265G>C 7.03e-07 1 / 0 3.08 - nan -
913 p.Asp913Glu c.2739T>A 2.05e-06 3 / 0 3.07 0.515 AMBIGUOUS 0.91
914 p.Ser914Cys c.2741C>G 1.37e-06 2 / 0 3.07 0.385 AMBIGUOUS 0.92
913 p.Asp913Val c.2738A>T 6.84e-07 1 / 0 3.07 - nan - rs1862800178
130 p.Ala130Ser c.388G>T 2.43e-04 354 / 0 3.07 0.069 BENIGN 0.49 rs139788349
142 p.Thr142Ile c.425C>T 6.88e-07 1 / 0 3.05 0.094 BENIGN 0.58
142 p.Thr142Ala c.424A>G 4.13e-06 6 / 0 3.05 - nan - rs765849642
753 p.Ile753Thr c.2258T>C 6.57e-06 1 / 0 3.04 0.890 PATHOGENIC 0.78 rs1862811191
753 p.Ile753Val c.2257A>G 6.84e-07 1 / 0 3.04 - nan -
444 p.Asn444Thr c.1331A>C 1.38e-06 2 / 0 3.03 0.952 PATHOGENIC 0.72
444 p.Asn444Ser c.1331A>G 4.14e-06 6 / 0 3.03 - nan - rs754750270
636 p.Leu636Val c.1906T>G 6.84e-07 1 / 0 3.03 0.637 PATHOGENIC 0.97
236 p.Asn236Lys c.708C>A 6.87e-07 1 / 0 3.03 0.201 BENIGN 0.50
630 p.Glu630Lys c.1888G>A 6.84e-07 1 / 0 3.01 0.844 PATHOGENIC 0.89 rs756992406

Complete RRCS results

Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.62, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.

Res1 AA1 Res2 AA2 Active RRCS Inactive RRCS ΔRRCS |ΔRRCS|
256 HIS 280 TYR 7.010 20.499 -13.489 13.489
337 ASN 340 GLN 12.492 0.786 11.707 11.707
362 ASN 386 GLN 13.851 3.431 10.420 10.420
322 GLU 346 ARG 0.000 10.135 -10.135 10.135
146 GLU 170 VAL 9.411 0.000 9.411 9.411
126 ARG 150 GLU 0.000 9.232 -9.232 9.232
113 GLN 135 ARG 0.000 9.194 -9.194 9.194
156 ARG 180 GLN 0.000 9.089 -9.089 9.089
163 ASN 187 ASN 0.000 9.087 -9.087 9.087
139 ASN 163 ASN 0.000 8.936 -8.936 8.936
329 THR 353 ASN 0.000 8.883 -8.883 8.883
233 ASN 256 HIS 8.533 17.265 -8.732 8.732
378 TYR 379 GLN 0.000 8.566 -8.566 8.566
165 LEU 187 ASN 0.000 8.566 -8.566 8.566
315 LEU 338 LEU 8.384 0.000 8.384 8.384
159 TRP 160 LEU 8.310 0.000 8.310 8.310
304 ARG 349 ASP 8.296 0.000 8.296 8.296
295 LEU 342 GLN 8.255 0.000 8.255 8.255
141 ILE 163 ASN 0.000 8.171 -8.171 8.171
642 GLU 643 ARG 0.115 8.171 -8.056 8.056
295 LEU 318 THR 0.000 8.011 -8.011 8.011
497 GLU 498 LYS 0.000 7.954 -7.954 7.954
131 LEU 178 THR 7.880 0.000 7.880 7.880
373 GLN 395 ASP 2.047 9.872 -7.826 7.826
533 GLU 603 GLY 0.000 7.754 -7.754 7.754
474 TRP 526 THR 0.000 7.660 -7.660 7.660
748 HIS 801 TYR 0.000 7.484 -7.484 7.484
312 PHE 359 PRO 7.198 0.000 7.198 7.198
69 ILE 91 ASN 1.113 8.207 -7.094 7.094
160 LEU 161 ASP 6.985 0.000 6.985 6.985
141 ILE 187 ASN 6.949 0.000 6.949 6.949
137 ASP 161 ASP 0.000 6.807 -6.807 6.807
275 ARG 297 ASP 3.448 10.234 -6.786 6.786
533 GLU 780 GLU 6.774 0.000 6.774 6.774
138 ALA 162 ASP 0.000 6.725 -6.725 6.725
402 HIS 424 GLU 8.516 1.934 6.583 6.583
137 ASP 185 ALA 6.493 0.000 6.493 6.493
306 ALA 353 ASN 6.473 0.000 6.473 6.473
293 HIS 341 GLU 6.427 0.000 6.427 6.427
327 THR 351 SER 0.000 6.350 -6.350 6.350
756 ASN 797 ASN 0.089 6.417 -6.328 6.328
759 PHE 793 PRO 7.282 1.136 6.146 6.146
314 ASN 335 PRO 6.130 0.000 6.130 6.130
237 LEU 259 SER 0.000 6.084 -6.084 6.084
352 TYR 373 GLN 7.876 1.859 6.018 6.018
357 ASP 378 TYR 0.000 5.992 -5.992 5.992
304 ARG 351 SER 5.738 0.000 5.738 5.738
155 LEU 178 THR 0.000 5.730 -5.730 5.730
161 ASP 183 THR 0.000 5.651 -5.651 5.651
122 SER 147 ASP 0.000 5.639 -5.639 5.639
135 ARG 159 TRP 0.000 5.568 -5.568 5.568
165 LEU 188 LYS 0.000 5.533 -5.533 5.533
798 PRO 803 PHE 5.531 0.000 5.531 5.531
280 TYR 304 ARG 5.524 0.000 5.524 5.524
299 HIS 346 ARG 5.507 0.000 5.507 5.507
679 PHE 706 PHE 9.090 3.612 5.478 5.478
529 PHE 696 PHE 1.144 6.617 -5.473 5.473
325 THR 349 ASP 0.000 5.461 -5.461 5.461
448 LYS 611 TRP 9.863 4.430 5.432 5.432
528 ALA 780 GLU 0.000 5.428 -5.428 5.428
113 GLN 137 ASP 4.806 10.203 -5.397 5.397
141 ILE 164 SER 0.000 5.391 -5.391 5.391
134 LEU 159 TRP 0.000 5.378 -5.378 5.378
131 LEU 155 LEU 0.000 5.353 -5.353 5.353
233 ASN 254 GLY 0.614 5.918 -5.304 5.304
316 THR 337 ASN 5.287 0.000 5.287 5.287
331 ILE 354 ASN 0.000 5.223 -5.223 5.223
138 ALA 186 LEU 5.142 0.000 5.142 5.142
162 ASP 186 LEU 0.000 5.140 -5.140 5.140
161 ASP 185 ALA 0.000 5.125 -5.125 5.125
299 HIS 322 GLU 0.000 5.104 -5.104 5.104
478 SER 518 ILE 5.075 0.000 5.075 5.075
307 SER 330 LYS 0.000 4.994 -4.994 4.994
799 VAL 804 PHE 5.158 0.173 4.985 4.985
63 ASP 87 GLN 10.785 5.801 4.983 4.983
302 VAL 349 ASP 4.966 0.000 4.966 4.966
812 TRP 816 LYS 0.000 4.916 -4.916 4.916
303 ILE 325 THR 0.000 4.911 -4.911 4.911
312 PHE 335 PRO 0.000 4.909 -4.909 4.909
141 ILE 188 LYS 4.897 0.000 4.897 4.897
211 ASN 235 ASN 3.015 7.892 -4.877 4.877
258 ASN 282 ASN 4.491 9.363 -4.872 4.872
533 GLU 534 TYR 0.000 4.857 -4.857 4.857
298 LEU 345 LEU 4.848 0.000 4.848 4.848
528 ALA 783 LYS 0.000 4.848 -4.848 4.848
136 LEU 159 TRP 0.000 4.804 -4.804 4.804
156 ARG 179 LEU 0.000 4.752 -4.752 4.752
698 THR 703 SER 4.903 0.173 4.730 4.730
649 ASP 656 SER 0.000 4.728 -4.728 4.728
309 VAL 354 ASN 4.693 0.000 4.693 4.693
729 TYR 746 ILE 5.317 0.630 4.687 4.687
303 ILE 350 LEU 4.660 0.000 4.660 4.660
309 VAL 330 LYS 0.000 4.658 -4.658 4.658
407 ARG 431 GLU 1.785 6.433 -4.648 4.648
751 TRP 800 LEU 4.852 0.210 4.641 4.641
377 ILE 399 ASN 4.257 8.897 -4.640 4.640
801 TYR 805 ASN 0.000 4.601 -4.601 4.601
32 PRO 46 LYS 0.000 4.588 -4.588 4.588
170 VAL 196 ALA 0.000 4.559 -4.559 4.559
328 GLY 352 TYR 0.000 4.558 -4.558 4.558
232 LEU 255 PHE 5.513 0.960 4.553 4.553
284 LEU 308 MET 4.531 0.000 4.531 4.531
321 LEU 345 LEU 0.000 4.521 -4.521 4.521
210 ASN 234 TYR 5.377 9.878 -4.502 4.502
374 ARG 398 ARG 11.078 6.582 4.496 4.496
299 HIS 344 MET 4.489 0.000 4.489 4.489
132 GLN 154 GLN 0.000 4.475 -4.475 4.475
277 ILE 302 VAL 4.472 0.000 4.472 4.472
305 GLY 352 TYR 4.461 0.000 4.461 4.461
237 LEU 258 ASN 3.490 7.950 -4.459 4.459
131 LEU 154 GLN 0.000 4.459 -4.459 4.459
339 CYS 361 PHE 0.000 4.448 -4.448 4.448
132 GLN 180 GLN 4.435 0.000 4.435 4.435
234 TYR 256 HIS 10.193 5.768 4.425 4.425
132 GLN 156 ARG 0.000 4.424 -4.424 4.424
686 GLU 703 SER 4.557 0.194 4.363 4.363
303 ILE 349 ASP 4.335 0.000 4.335 4.335
9 CYS 10 PHE 0.000 4.331 -4.331 4.331
715 SER 760 PHE 6.947 2.638 4.310 4.310
284 LEU 309 VAL 4.307 0.000 4.307 4.307
895 TYR 896 TRP 4.379 0.078 4.301 4.301
160 LEU 183 THR 0.000 4.292 -4.292 4.292
656 SER 658 HIS 0.120 4.400 -4.280 4.280
134 LEU 182 LEU 4.267 0.000 4.267 4.267
278 HIS 280 TYR 6.118 1.866 4.252 4.252
276 THR 300 SER 4.247 0.000 4.247 4.247
92 ASP 116 GLN 0.077 4.324 -4.247 4.247
304 ARG 327 THR 0.000 4.240 -4.240 4.240
296 SER 320 HIS 0.000 4.230 -4.230 4.230
718 PHE 760 PHE 0.406 4.634 -4.228 4.228
298 LEU 321 LEU 0.000 4.217 -4.217 4.217
164 SER 188 LYS 0.000 4.212 -4.212 4.212
737 LEU 743 SER 0.000 4.194 -4.194 4.194
468 TYR 609 GLY 0.049 4.221 -4.172 4.172
135 ARG 183 THR 4.169 0.000 4.169 4.169
245 LYS 269 ASP 4.319 0.159 4.160 4.160
706 PHE 710 LEU 4.423 0.268 4.155 4.155
256 HIS 278 HIS 0.000 4.151 -4.151 4.151
132 GLN 155 LEU 0.000 4.139 -4.139 4.139
131 LEU 179 LEU 4.136 0.000 4.136 4.136
301 LEU 325 THR 0.000 4.122 -4.122 4.122
741 SER 807 LYS 0.000 4.106 -4.106 4.106
46 LYS 67 ASN 0.000 4.087 -4.087 4.087
255 PHE 280 TYR 4.071 0.000 4.071 4.071
737 LEU 742 GLN 4.070 0.000 4.070 4.070
117 LEU 140 HIS 1.631 5.701 -4.070 4.070
155 LEU 179 LEU 0.000 4.058 -4.058 4.058
137 ASP 159 TRP 0.000 4.052 -4.052 4.052
112 LEU 137 ASP 4.112 0.062 4.050 4.050
303 ILE 326 LEU 0.000 4.042 -4.042 4.042
279 LEU 303 ILE 4.217 0.184 4.032 4.032
752 LEU 797 ASN 0.000 4.002 -4.002 4.002
278 HIS 302 VAL 4.001 0.000 4.001 4.001
302 VAL 325 THR 0.000 3.999 -3.999 3.999
157 HIS 159 TRP 0.000 3.996 -3.996 3.996
649 ASP 654 GLY 1.249 5.243 -3.995 3.995
330 LYS 354 ASN 0.000 3.988 -3.988 3.988
542 ARG 546 TRP 0.000 3.980 -3.980 3.980
300 SER 347 THR 3.980 0.000 3.980 3.980
88 LEU 113 GLN 3.956 0.005 3.951 3.951
759 PHE 789 PHE 0.808 4.745 -3.938 3.938
289 ASN 316 THR 3.932 0.000 3.932 3.932
532 CYS 605 PHE 0.000 3.920 -3.920 3.920
474 TRP 532 CYS 3.912 0.000 3.912 3.912
306 ALA 329 THR 0.000 3.890 -3.890 3.890
237 LEU 260 ILE 0.132 4.022 -3.890 3.890
323 SER 347 THR 0.000 3.851 -3.851 3.851
132 GLN 157 HIS 0.000 3.845 -3.845 3.845
640 THR 725 TYR 7.361 3.518 3.843 3.843
318 THR 342 GLN 0.000 3.823 -3.823 3.823
327 THR 349 ASP 0.000 3.772 -3.772 3.772
299 HIS 321 LEU 0.000 3.767 -3.767 3.767
307 SER 354 ASN 3.764 0.000 3.764 3.764
573 SER 643 ARG 0.000 3.758 -3.758 3.758
209 HIS 210 ASN 0.000 3.753 -3.753 3.753
279 LEU 304 ARG 3.723 0.000 3.723 3.723
324 LEU 347 THR 0.000 3.722 -3.722 3.722
906 SER 907 ASP 0.000 3.720 -3.720 3.720
779 PRO 780 GLU 0.000 3.673 -3.673 3.673
159 TRP 183 THR 0.000 3.663 -3.663 3.663
298 LEU 344 MET 3.655 0.000 3.655 3.655
136 LEU 185 ALA 3.628 0.000 3.628 3.628
280 TYR 302 VAL 3.611 0.000 3.611 3.611
421 SER 442 VAL 8.215 4.610 3.606 3.606
129 SER 178 THR 3.596 0.000 3.596 3.596
801 TYR 808 PHE 0.000 3.593 -3.593 3.593
539 TRP 540 MET 3.586 0.000 3.586 3.586
300 SER 323 SER 0.000 3.582 -3.582 3.582
301 LEU 324 LEU 0.000 3.575 -3.575 3.575
725 TYR 750 ALA 0.000 3.569 -3.569 3.569
324 LEU 349 ASP 0.000 3.564 -3.564 3.564
332 SER 355 ILE 0.000 3.547 -3.547 3.547
158 LEU 159 TRP 3.532 0.000 3.532 3.532
532 CYS 606 ALA 0.000 3.532 -3.532 3.532
166 THR 189 ILE 0.000 3.513 -3.513 3.513
44 SER 63 ASP 0.089 3.600 -3.511 3.511
301 LEU 349 ASP 3.500 0.000 3.500 3.500
481 ASN 517 GLN 0.000 3.495 -3.495 3.495
85 GLU 87 GLN 0.000 3.495 -3.495 3.495
337 ASN 341 GLU 0.000 3.494 -3.494 3.494
185 ALA 209 HIS 4.124 7.617 -3.494 3.494
133 SER 181 ALA 3.491 0.000 3.491 3.491
301 LEU 348 LEU 3.487 0.000 3.487 3.487
572 SER 642 GLU 5.085 8.561 -3.476 3.476
322 GLU 345 LEU 0.000 3.461 -3.461 3.461
189 ILE 212 LYS 2.272 5.731 -3.459 3.459
324 LEU 348 LEU 0.000 3.457 -3.457 3.457
132 GLN 179 LEU 3.440 0.000 3.440 3.440
156 ARG 181 ALA 0.000 3.438 -3.438 3.438
136 LEU 183 THR 3.409 0.000 3.409 3.409
326 LEU 350 LEU 0.000 3.380 -3.380 3.380
134 LEU 183 THR 3.375 0.000 3.375 3.375
208 LEU 233 ASN 3.369 0.000 3.369 3.369
326 LEU 349 ASP 0.000 3.366 -3.366 3.366
533 GLU 605 PHE 0.379 3.743 -3.364 3.364
153 VAL 178 THR 0.000 3.362 -3.362 3.362
301 LEU 347 THR 3.351 0.000 3.351 3.351
93 LEU 115 ASN 4.809 8.159 -3.350 3.350
310 GLN 331 ILE 0.000 3.349 -3.349 3.349
301 LEU 323 SER 0.000 3.344 -3.344 3.344
134 LEU 181 ALA 3.329 0.000 3.329 3.329
166 THR 188 LYS 0.000 3.307 -3.307 3.307
129 SER 154 GLN 0.000 3.301 -3.301 3.301
566 SER 811 ASP 3.295 0.000 3.295 3.295
184 LEU 209 HIS 3.280 0.000 3.280 3.280
299 HIS 345 LEU 3.265 0.000 3.265 3.265
285 SER 308 MET 2.159 5.423 -3.264 3.264
158 LEU 182 LEU 0.000 3.245 -3.245 3.245
529 PHE 783 LYS 0.000 3.232 -3.232 3.232
111 THR 113 GLN 0.314 3.539 -3.225 3.225
310 GLN 330 LYS 0.000 3.225 -3.225 3.225
275 ARG 300 SER 3.549 0.326 3.224 3.224
172 PRO 196 ALA 3.221 0.000 3.221 3.221
285 SER 306 ALA 0.000 3.219 -3.219 3.219
332 SER 354 ASN 0.000 3.216 -3.216 3.216
132 GLN 181 ALA 3.207 0.000 3.207 3.207
305 GLY 328 GLY 0.000 3.197 -3.197 3.197
539 TRP 602 TRP 0.000 3.179 -3.179 3.179
134 LEU 157 HIS 0.000 3.151 -3.151 3.151
299 HIS 347 THR 3.149 0.000 3.149 3.149
555 PHE 803 PHE 5.077 1.933 3.144 3.144
577 ILE 801 TYR 0.495 3.622 -3.128 3.128
292 PHE 301 LEU 1.451 4.576 -3.124 3.124
542 ARG 598 ASP 11.179 8.055 3.124 3.124
134 LEU 158 LEU 0.000 3.100 -3.100 3.100
133 SER 159 TRP 0.000 3.097 -3.097 3.097
231 ASP 254 GLY 4.420 1.327 3.094 3.094
149 PHE 176 LEU 0.000 3.085 -3.085 3.085
89 ALA 113 GLN 3.593 6.677 -3.085 3.085
913 ASP 914 SER 1.325 4.394 -3.068 3.068
130 ALA 178 THR 3.068 0.000 3.068 3.068
139 ASN 162 ASP 0.000 3.059 -3.059 3.059
142 THR 188 LYS 3.052 0.000 3.052 3.052
289 ASN 313 PRO 0.000 3.052 -3.052 3.052
725 TYR 753 ILE 1.061 4.105 -3.044 3.044
534 TYR 602 TRP 0.303 3.342 -3.040 3.040
139 ASN 187 ASN 3.038 0.000 3.038 3.038
331 ILE 355 ILE 0.000 3.034 -3.034 3.034
425 LEU 444 ASN 4.440 7.471 -3.031 3.031
636 LEU 801 TYR 3.031 0.000 3.031 3.031
236 ASN 259 SER 3.031 0.000 3.031 3.031
303 ILE 327 THR 0.000 3.031 -3.031 3.031
748 HIS 805 ASN 0.000 3.026 -3.026 3.026
630 GLU 710 LEU 2.118 5.129 -3.011 3.011
141 ILE 165 LEU 0.000 3.007 -3.007 3.007
136 LEU 184 LEU 3.003 0.000 3.003 3.003
803 PHE 808 PHE 2.991 0.000 2.991 2.991
277 ILE 300 SER 2.976 0.000 2.976 2.976
140 HIS 188 LYS 2.961 0.000 2.961 2.961
389 ILE 413 GLY 2.944 0.000 2.944 2.944
158 LEU 181 ALA 0.000 2.936 -2.936 2.936
356 ARG 378 TYR 0.756 3.682 -2.926 2.926
303 ILE 353 ASN 2.920 0.000 2.920 2.920
142 THR 164 SER 0.000 2.917 -2.917 2.917
650 ILE 742 GLN 0.000 2.910 -2.910 2.910
486 ASP 487 ASN 0.000 2.902 -2.902 2.902
530 LYS 689 ALA 0.626 3.506 -2.879 2.879
445 PHE 466 TYR 6.294 3.419 2.875 2.875
321 LEU 344 MET 0.000 2.874 -2.874 2.874
118 LYS 140 HIS 0.981 3.851 -2.870 2.870
130 ALA 154 GLN 0.000 2.870 -2.870 2.870
91 ASN 115 ASN 7.208 10.074 -2.867 2.867
150 GLU 175 ASN 0.000 2.861 -2.861 2.861
155 LEU 156 ARG 2.860 0.000 2.860 2.860
714 ASN 760 PHE 5.950 3.100 2.850 2.850
212 LYS 236 ASN 0.000 2.845 -2.845 2.845
321 LEU 342 GLN 0.000 2.845 -2.845 2.845
277 ILE 301 LEU 2.838 0.000 2.838 2.838
756 ASN 793 PRO 0.000 2.800 -2.800 2.800
567 CYS 818 ARG 4.541 7.340 -2.800 2.800
587 MET 790 PHE 5.835 3.038 2.798 2.798
309 VAL 329 THR 0.000 2.794 -2.794 2.794
84 GLU 108 LYS 9.087 11.880 -2.793 2.793
529 PHE 779 PRO 0.000 2.778 -2.778 2.778
468 TYR 610 ILE 0.576 3.330 -2.754 2.754
907 ASP 908 TYR 0.000 2.744 -2.744 2.744
260 ILE 282 ASN 4.761 7.501 -2.740 2.740
378 TYR 400 LEU 6.310 3.572 2.737 2.737
184 LEU 208 LEU 3.540 0.811 2.729 2.729
326 LEU 353 ASN 0.000 2.723 -2.723 2.723
279 LEU 302 VAL 5.026 2.320 2.706 2.706
281 ASP 305 GLY 2.677 0.000 2.677 2.677
132 GLN 178 THR 2.675 0.000 2.675 2.675
234 TYR 257 SER 4.179 6.853 -2.673 2.673
531 PRO 605 PHE 0.000 2.669 -2.669 2.669
64 ILE 89 ALA 2.663 0.000 2.663 2.663
292 PHE 318 THR 0.000 2.657 -2.657 2.657
725 TYR 749 VAL 1.619 4.273 -2.654 2.654
556 ASN 798 PRO 3.487 6.126 -2.639 2.639
491 ASP 492 HIS 0.000 2.636 -2.636 2.636
505 ASN 508 SER 0.460 3.079 -2.620 2.620
312 PHE 350 LEU 3.365 0.750 2.615 2.615
298 LEU 342 GLN 2.604 0.000 2.604 2.604
89 ALA 111 THR 0.000 2.594 -2.594 2.594
725 TYR 746 ILE 0.000 2.589 -2.589 2.589
281 ASP 304 ARG 2.588 0.000 2.588 2.588
316 THR 336 ASN 2.587 0.000 2.587 2.587
157 HIS 181 ALA 0.000 2.578 -2.578 2.578
865 LEU 866 LEU 0.000 2.575 -2.575 2.575
111 THR 135 ARG 4.167 1.598 2.569 2.569
209 HIS 233 ASN 7.400 4.842 2.559 2.559
533 GLU 604 ARG 0.000 2.555 -2.555 2.555
613 GLU 691 PRO 3.013 5.562 -2.548 2.548
239 GLU 260 ILE 0.542 3.085 -2.542 2.542
122 SER 148 SER 0.000 2.530 -2.530 2.530
310 GLN 354 ASN 2.526 0.000 2.526 2.526
613 GLU 690 SER 2.761 5.282 -2.521 2.521
160 LEU 187 ASN 0.000 2.517 -2.517 2.517
729 TYR 733 GLU 2.515 0.000 2.515 2.515
165 LEU 189 ILE 0.000 2.511 -2.511 2.511
177 PRO 199 ASN 0.000 2.510 -2.510 2.510
136 LEU 163 ASN 0.000 2.491 -2.491 2.491
299 HIS 323 SER 0.000 2.489 -2.489 2.489
287 VAL 309 VAL 0.000 2.478 -2.478 2.478
371 SER 395 ASP 3.907 1.432 2.475 2.475
356 ARG 376 GLN 6.194 8.663 -2.469 2.469
257 SER 281 ASP 4.252 6.717 -2.465 2.465
566 SER 568 THR 2.842 0.389 2.453 2.453
144 VAL 172 PRO 0.326 2.774 -2.448 2.448
149 PHE 172 PRO 0.000 2.448 -2.448 2.448
385 PHE 412 LEU 4.015 1.570 2.446 2.446
158 LEU 183 THR 0.000 2.441 -2.441 2.441
275 ARG 299 HIS 4.714 2.287 2.427 2.427
112 LEU 136 LEU 3.396 0.997 2.400 2.400
146 GLU 172 PRO 0.074 2.473 -2.399 2.399
564 PHE 578 GLY 0.038 2.432 -2.395 2.395
113 GLN 114 ASN 2.364 0.000 2.364 2.364
827 SER 828 VAL 0.000 2.360 -2.360 2.360
294 ASN 316 THR 0.000 2.353 -2.353 2.353
596 PHE 600 VAL 0.000 2.350 -2.350 2.350
63 ASP 65 SER 1.654 4.001 -2.347 2.347
45 GLY 67 ASN 4.034 1.688 2.346 2.346
391 LEU 414 PRO 1.435 3.778 -2.342 2.342
748 HIS 752 LEU 0.696 3.020 -2.324 2.324
241 PRO 255 PHE 2.322 0.000 2.322 2.322
43 CYS 65 SER 2.495 0.175 2.320 2.320
539 TRP 542 ARG 0.000 2.317 -2.317 2.317
190 SER 212 LYS 1.260 3.577 -2.317 2.317
442 VAL 464 VAL 0.355 2.658 -2.304 2.304
872 CYS 873 LYS 2.299 0.000 2.299 2.299
94 SER 117 LEU 2.621 0.325 2.296 2.296
298 LEU 320 HIS 0.000 2.287 -2.287 2.287
643 ARG 801 TYR 2.283 0.000 2.283 2.283
232 LEU 258 ASN 4.522 2.240 2.283 2.283
47 GLY 67 ASN 0.621 2.898 -2.278 2.278
877 LYS 878 SER 0.000 2.278 -2.278 2.278
312 PHE 361 PHE 2.276 0.000 2.276 2.276
285 SER 307 SER 0.000 2.273 -2.273 2.273
696 PHE 786 THR 0.000 2.271 -2.271 2.271
40 ARG 85 GLU 2.268 0.000 2.268 2.268
797 ASN 801 TYR 2.264 0.000 2.264 2.264
167 GLU 189 ILE 0.000 2.261 -2.261 2.261
136 LEU 187 ASN 2.261 0.000 2.261 2.261
122 SER 123 GLU 2.663 0.403 2.260 2.260
744 SER 806 PRO 0.000 2.257 -2.257 2.257
696 PHE 703 SER 0.000 2.255 -2.255 2.255
331 ILE 353 ASN 0.000 2.254 -2.254 2.254
233 ASN 255 PHE 1.363 3.607 -2.244 2.244
322 GLU 344 MET 0.000 2.243 -2.243 2.243
371 SER 373 GLN 0.651 2.892 -2.242 2.242
322 GLU 347 THR 0.000 2.236 -2.236 2.236
163 ASN 186 LEU 0.000 2.207 -2.207 2.207
542 ARG 602 TRP 6.920 9.124 -2.205 2.205
869 PRO 870 VAL 0.000 2.199 -2.199 2.199
378 TYR 402 HIS 3.878 6.077 -2.199 2.199
133 SER 157 HIS 0.000 2.197 -2.197 2.197
148 SER 172 PRO 0.000 2.194 -2.194 2.194
292 PHE 315 LEU 3.039 0.850 2.188 2.188
697 PRO 770 PRO 0.000 2.183 -2.183 2.183
360 SER 362 ASN 3.081 0.902 2.179 2.179
388 LEU 412 LEU 3.108 0.937 2.171 2.171
128 LEU 152 LEU 0.000 2.170 -2.170 2.170
534 TYR 783 LYS 2.184 0.037 2.148 2.148
892 PRO 893 GLU 2.139 0.000 2.139 2.139
255 PHE 258 ASN 2.322 0.185 2.137 2.137
119 THR 143 SER 0.000 2.131 -2.131 2.131
305 GLY 327 THR 0.000 2.126 -2.126 2.126
584 ASN 797 ASN 4.270 2.150 2.120 2.120
576 PHE 638 LEU 1.842 3.959 -2.116 2.116
897 SER 898 ASP 2.706 4.813 -2.108 2.108
88 LEU 112 LEU 3.302 1.197 2.105 2.105
529 PHE 691 PRO 0.644 2.748 -2.104 2.104
112 LEU 139 ASN 4.661 2.564 2.097 2.097
305 GLY 353 ASN 2.085 0.000 2.085 2.085
683 HIS 686 GLU 1.885 3.958 -2.073 2.073
149 PHE 158 LEU 0.000 2.072 -2.072 2.072
294 ASN 318 THR 0.000 2.071 -2.071 2.071
282 ASN 306 ALA 2.069 0.000 2.069 2.069
280 TYR 281 ASP 0.000 2.069 -2.069 2.069
184 LEU 211 ASN 4.936 2.870 2.066 2.066
258 ASN 281 ASP 0.000 2.063 -2.063 2.063
584 ASN 794 ALA 6.342 8.398 -2.056 2.056
138 ALA 185 ALA 2.056 0.000 2.056 2.056
164 SER 187 ASN 0.000 2.052 -2.052 2.052
315 LEU 342 GLN 0.000 2.052 -2.052 2.052
382 GLU 408 ALA 0.045 2.092 -2.047 2.047
909 ALA 910 ASP 0.000 2.047 -2.047 2.047
388 LEU 413 GLY 2.040 0.000 2.040 2.040
148 SER 175 ASN 0.000 2.038 -2.038 2.038
535 LEU 783 LYS 4.612 2.590 2.023 2.023
174 SER 199 ASN 1.553 3.569 -2.017 2.017
634 PHE 673 ALA 0.000 2.010 -2.010 2.010
751 TRP 755 THR 2.007 0.000 2.007 2.007
49 THR 68 ASN 0.926 2.929 -2.003 2.003
878 SER 879 HIS 1.999 0.000 1.999 1.999
450 ALA 607 GLU 1.992 0.000 1.992 1.992
145 PRO 148 SER 0.000 1.989 -1.989 1.989
748 HIS 800 LEU 0.017 2.006 -1.989 1.989
574 LYS 811 ASP 3.519 5.507 -1.988 1.988
355 ILE 375 ASN 7.204 9.182 -1.978 1.978
293 HIS 316 THR 0.000 1.977 -1.977 1.977
373 GLN 397 SER 4.093 6.069 -1.976 1.976
329 THR 352 TYR 0.000 1.976 -1.976 1.976
48 LEU 68 ASN 3.691 5.665 -1.974 1.974
96 ILE 121 PRO 2.562 0.590 1.972 1.972
352 TYR 374 ARG 15.871 13.903 1.968 1.968
294 ASN 317 GLY 0.000 1.961 -1.961 1.961
828 VAL 829 SER 0.000 1.960 -1.960 1.960
284 LEU 305 GLY 0.000 1.959 -1.959 1.959
576 PHE 639 ALA 1.248 3.205 -1.958 1.958
612 TRP 691 PRO 3.069 5.023 -1.954 1.954
303 ILE 351 SER 1.939 0.000 1.939 1.939
737 LEU 747 LYS 0.000 1.928 -1.928 1.928
745 MET 807 LYS 0.000 1.920 -1.920 1.920
189 ILE 211 ASN 6.152 8.069 -1.918 1.918
421 SER 440 LYS 4.375 2.461 1.914 1.914
144 VAL 169 PRO 0.000 1.910 -1.910 1.910
442 VAL 463 SER 2.858 4.766 -1.908 1.908
272 PRO 297 ASP 2.156 0.250 1.906 1.906
912 GLU 913 ASP 1.900 0.000 1.900 1.900
634 PHE 669 ALA 0.946 2.841 -1.895 1.895
125 ILE 152 LEU 0.000 1.895 -1.895 1.895
613 GLU 688 SER 5.045 6.938 -1.893 1.893
563 THR 570 LEU 0.177 2.066 -1.890 1.890
631 SER 670 PHE 0.000 1.890 -1.890 1.890
93 LEU 117 LEU 5.616 3.728 1.888 1.888
555 PHE 799 VAL 1.151 3.039 -1.888 1.888
604 ARG 607 GLU 6.205 4.321 1.884 1.884
194 ASP 217 SER 9.482 7.605 1.877 1.877
168 VAL 197 PHE 0.000 1.871 -1.871 1.871
568 THR 574 LYS 1.868 0.000 1.868 1.868
392 ARG 416 THR 8.342 6.477 1.865 1.865
125 ILE 176 LEU 1.860 0.000 1.860 1.860
296 SER 344 MET 1.856 0.000 1.856 1.856
119 THR 145 PRO 0.000 1.853 -1.853 1.853
7 LEU 8 LEU 0.000 1.852 -1.852 1.852
119 THR 141 ILE 0.000 1.851 -1.851 1.851
876 ILE 877 LYS 2.010 0.163 1.846 1.846
208 LEU 232 LEU 2.875 1.029 1.846 1.846
410 ALA 431 GLU 2.158 3.995 -1.837 1.837
679 PHE 683 HIS 2.062 3.897 -1.835 1.835
211 ASN 234 TYR 0.159 1.994 -1.834 1.834
117 LEU 139 ASN 8.943 7.111 1.833 1.833
138 ALA 161 ASP 0.000 1.829 -1.829 1.829
88 LEU 111 THR 3.693 5.517 -1.824 1.824
296 SER 317 GLY 0.000 1.821 -1.821 1.821
755 THR 759 PHE 2.760 0.940 1.821 1.821
743 SER 747 LYS 1.191 3.011 -1.820 1.820
379 GLN 381 LYS 1.461 3.281 -1.820 1.820
426 THR 447 LEU 1.473 3.288 -1.815 1.815
46 LYS 66 MET 2.080 0.275 1.805 1.805
306 ALA 328 GLY 0.000 1.805 -1.805 1.805
90 GLY 114 ASN 4.293 6.097 -1.804 1.804
290 SER 293 HIS 0.300 2.098 -1.799 1.799
412 LEU 415 ILE 2.726 0.930 1.796 1.796
159 TRP 161 ASP 0.000 1.795 -1.795 1.795
651 MET 735 GLU 1.791 0.000 1.791 1.791
612 TRP 618 CYS 9.236 11.023 -1.787 1.787
468 TYR 605 PHE 1.305 3.092 -1.786 1.786
176 LEU 200 LEU 0.510 2.292 -1.781 1.781
421 SER 441 LEU 2.416 0.635 1.781 1.781
312 PHE 331 ILE 0.000 1.777 -1.777 1.777
752 LEU 801 TYR 1.768 0.000 1.768 1.768
529 PHE 782 MET 0.000 1.767 -1.767 1.767
347 THR 369 GLU 5.945 4.190 1.755 1.755
179 LEU 202 SER 6.966 5.211 1.755 1.755
711 VAL 760 PHE 0.754 2.508 -1.754 1.754
293 HIS 314 ASN 0.000 1.746 -1.746 1.746
643 ARG 646 SER 0.000 1.741 -1.741 1.741
637 MET 717 ALA 0.523 2.258 -1.735 1.735
29 CYS 35 CYS 4.168 5.901 -1.733 1.733
888 SER 889 CYS 0.000 1.730 -1.730 1.730
467 ALA 526 THR 2.811 1.086 1.726 1.726
751 TRP 804 PHE 1.724 0.000 1.724 1.724
66 MET 90 GLY 3.059 4.775 -1.717 1.717
744 SER 805 ASN 0.000 1.716 -1.716 1.716
155 LEU 176 LEU 0.000 1.712 -1.712 1.712
873 LYS 874 HIS 1.703 0.000 1.703 1.703
240 PHE 255 PHE 2.260 0.557 1.703 1.703
314 ASN 316 THR 5.782 4.080 1.701 1.701
559 VAL 802 VAL 2.285 0.585 1.700 1.700
293 HIS 318 THR 0.000 1.700 -1.700 1.700
651 MET 731 ASN 0.000 1.698 -1.698 1.698
468 TYR 606 ALA 1.634 3.327 -1.692 1.692
336 ASN 359 PRO 0.000 1.689 -1.689 1.689
158 LEU 160 LEU 0.000 1.685 -1.685 1.685
902 GLN 903 SER 1.684 0.000 1.684 1.684
268 PHE 292 PHE 4.978 3.295 1.683 1.683
758 ILE 789 PHE 1.682 0.000 1.682 1.682
162 ASP 185 ALA 0.000 1.681 -1.681 1.681
559 VAL 801 TYR 0.000 1.680 -1.680 1.680
386 GLN 411 THR 3.475 1.795 1.680 1.680
140 HIS 163 ASN 0.000 1.680 -1.680 1.680
87 GLN 111 THR 3.464 5.142 -1.677 1.677
477 ASP 518 ILE 1.670 0.000 1.670 1.670
629 SER 630 GLU 0.000 1.668 -1.668 1.668
116 GLN 140 HIS 4.047 2.388 1.660 1.660
756 ASN 801 TYR 1.651 0.000 1.651 1.651
800 LEU 801 TYR 1.646 0.000 1.646 1.646
866 LEU 867 THR 0.000 1.645 -1.645 1.645
29 CYS 34 SER 0.000 1.643 -1.643 1.643
294 ASN 341 GLU 1.642 0.000 1.642 1.642
546 TRP 595 THR 7.922 6.280 1.642 1.642
778 SER 781 ILE 0.824 2.452 -1.628 1.628
419 ASP 440 LYS 8.877 10.500 -1.624 1.624
266 GLY 291 ALA 2.304 0.686 1.618 1.618
468 TYR 531 PRO 0.341 1.955 -1.614 1.614
831 SER 832 SER 1.845 0.236 1.610 1.610
156 ARG 157 HIS 0.261 1.868 -1.607 1.607
695 PRO 707 THR 3.110 4.707 -1.598 1.598
120 VAL 144 VAL 0.000 1.596 -1.596 1.596
649 ASP 658 HIS 3.348 1.753 1.594 1.594
555 PHE 802 VAL 0.000 1.581 -1.581 1.581
32 PRO 48 LEU 2.308 0.734 1.574 1.574
120 VAL 148 SER 0.000 1.572 -1.572 1.572
144 VAL 148 SER 0.000 1.572 -1.572 1.572
769 ALA 775 ILE 1.817 0.246 1.571 1.571
704 LEU 771 LEU 2.626 1.057 1.569 1.569
874 HIS 875 LEU 1.566 0.000 1.566 1.566
692 LEU 696 PHE 0.000 1.559 -1.559 1.559
910 ASP 911 GLU 0.000 1.558 -1.558 1.558
384 THR 385 PHE 1.820 3.368 -1.548 1.548
207 HIS 209 HIS 2.942 1.396 1.546 1.546
351 SER 373 GLN 10.246 8.700 1.546 1.546
64 ILE 88 LEU 3.900 2.356 1.544 1.544
940 VAL 942 TYR 2.047 0.511 1.536 1.536
476 CYS 520 ILE 1.535 0.000 1.535 1.535
232 LEU 256 HIS 1.544 0.018 1.527 1.527
802 VAL 808 PHE 6.802 8.327 -1.525 1.525
765 PHE 766 PHE 0.805 2.328 -1.523 1.523
28 LEU 38 ASP 0.360 1.879 -1.519 1.519
214 ARG 237 LEU 2.636 1.119 1.516 1.516
120 VAL 149 PHE 0.000 1.515 -1.515 1.515
772 ILE 775 ILE 0.000 1.511 -1.511 1.511
300 SER 321 LEU 0.000 1.508 -1.508 1.508
361 PHE 386 GLN 1.647 0.139 1.508 1.508
282 ASN 305 GLY 1.504 0.000 1.504 1.504
718 PHE 721 MET 0.100 1.603 -1.503 1.503
896 TRP 897 SER 0.486 1.987 -1.502 1.502
158 LEU 179 LEU 0.000 1.501 -1.501 1.501
166 THR 190 SER 0.000 1.500 -1.500 1.500
256 HIS 281 ASP 1.497 0.000 1.497 1.497
402 HIS 403 GLU 0.000 1.496 -1.496 1.496
213 ILE 236 ASN 4.620 6.109 -1.489 1.489
293 HIS 294 ASN 1.507 0.020 1.488 1.488
548 ILE 795 CYS 2.593 1.111 1.482 1.482
118 LYS 142 THR 1.186 2.665 -1.480 1.480
307 SER 328 GLY 0.000 1.474 -1.474 1.474
269 ASP 293 HIS 1.583 3.055 -1.472 1.472
851 LEU 852 GLN 0.049 1.516 -1.467 1.467
313 PRO 326 LEU 0.000 1.463 -1.463 1.463
751 TRP 754 PHE 0.000 1.462 -1.462 1.462
401 ILE 423 ASN 7.832 9.292 -1.460 1.460
528 ALA 779 PRO 4.233 2.774 1.458 1.458
65 SER 87 GLN 0.000 1.458 -1.458 1.458
351 SER 371 SER 3.129 1.671 1.458 1.458
473 PHE 520 ILE 0.702 2.158 -1.456 1.456
562 THR 808 PHE 4.250 2.795 1.455 1.455
890 GLN 891 ARG 2.356 0.905 1.450 1.450
198 THR 223 GLY 0.000 1.447 -1.447 1.447
556 ASN 581 SER 8.451 9.896 -1.445 1.445
286 PHE 308 MET 0.000 1.444 -1.444 1.444
711 VAL 768 PHE 3.302 1.859 1.442 1.442
338 LEU 361 PHE 1.441 0.000 1.441 1.441
244 ILE 255 PHE 1.437 0.000 1.437 1.437
334 ILE 350 LEU 0.000 1.436 -1.436 1.436
891 ARG 892 PRO 2.833 1.400 1.433 1.433
346 ARG 367 LEU 3.852 5.285 -1.433 1.433
185 ALA 207 HIS 0.000 1.426 -1.426 1.426
98 PRO 124 ALA 5.166 3.742 1.424 1.424
334 ILE 359 PRO 1.762 3.182 -1.421 1.421
145 PRO 147 ASP 0.000 1.412 -1.412 1.412
161 ASP 162 ASP 1.411 0.000 1.411 1.411
42 ASP 44 SER 4.916 3.509 1.407 1.407
339 CYS 362 ASN 0.000 1.406 -1.406 1.406
636 LEU 752 LEU 0.000 1.400 -1.400 1.400
426 THR 446 LYS 1.374 2.772 -1.398 1.398
304 ARG 353 ASN 1.392 0.000 1.392 1.392
315 LEU 337 ASN 1.392 0.000 1.392 1.392
365 HIS 387 GLY 4.335 2.949 1.386 1.386
258 ASN 283 PRO 0.000 1.386 -1.386 1.386
134 LEU 155 LEU 0.000 1.380 -1.380 1.380
267 ALA 291 ALA 2.181 0.804 1.377 1.377
546 TRP 549 PHE 1.374 0.000 1.374 1.374
577 ILE 802 VAL 1.371 0.000 1.371 1.371
93 LEU 116 GLN 5.110 6.480 -1.370 1.370
395 ASP 419 ASP 3.556 4.922 -1.366 1.366
640 THR 753 ILE 0.000 1.365 -1.365 1.365
299 HIS 320 HIS 0.000 1.365 -1.365 1.365
696 PHE 782 MET 1.408 0.049 1.359 1.359
745 MET 805 ASN 0.000 1.357 -1.357 1.357
67 ASN 90 GLY 1.034 2.390 -1.356 1.356
156 ARG 178 THR 0.000 1.350 -1.350 1.350
538 SER 541 ILE 2.510 1.162 1.348 1.348
536 LEU 787 LEU 2.387 1.042 1.345 1.345
652 LYS 653 ASN 1.344 0.000 1.344 1.344
68 ASN 91 ASN 0.000 1.344 -1.344 1.344
261 SER 284 LEU 3.810 2.467 1.343 1.343
289 ASN 314 ASN 5.927 7.268 -1.341 1.341
173 LEU 182 LEU 0.000 1.338 -1.338 1.338
148 SER 149 PHE 0.000 1.335 -1.335 1.335
115 ASN 138 ALA 2.898 1.566 1.333 1.333
190 SER 213 ILE 2.206 3.538 -1.332 1.332
555 PHE 798 PRO 2.038 3.365 -1.327 1.327
207 HIS 231 ASP 3.268 1.941 1.327 1.327
864 PHE 865 LEU 0.000 1.325 -1.325 1.325
197 PHE 220 CYS 2.880 1.560 1.320 1.320
40 ARG 61 ALA 3.920 2.601 1.319 1.319
256 HIS 282 ASN 0.261 1.579 -1.318 1.318
129 SER 151 GLY 0.000 1.315 -1.315 1.315
557 LEU 585 LEU 0.020 1.335 -1.315 1.315
534 TYR 542 ARG 2.756 1.443 1.312 1.312
636 LEU 753 ILE 0.000 1.300 -1.300 1.300
96 ILE 117 LEU 2.142 0.843 1.299 1.299
137 ASP 163 ASN 0.000 1.297 -1.297 1.297
198 THR 222 ASP 1.725 3.020 -1.295 1.295
389 ILE 414 PRO 0.712 2.005 -1.293 1.293
738 SER 739 GLU 0.000 1.291 -1.291 1.291
324 LEU 345 LEU 0.000 1.285 -1.285 1.285
134 LEU 179 LEU 1.282 0.000 1.282 1.282
338 LEU 364 CYS 1.282 0.000 1.282 1.282
619 LYS 688 SER 0.000 1.280 -1.280 1.280
331 ILE 333 SER 1.277 0.000 1.277 1.277
256 HIS 279 LEU 0.000 1.274 -1.274 1.274
309 VAL 331 ILE 0.000 1.271 -1.271 1.271
695 PRO 706 PHE 0.495 1.764 -1.270 1.270
38 ASP 59 THR 1.607 2.873 -1.266 1.266
244 ILE 268 PHE 0.000 1.264 -1.264 1.264
157 HIS 179 LEU 0.000 1.261 -1.261 1.261
109 VAL 133 SER 2.686 3.946 -1.260 1.260
354 ASN 376 GLN 4.794 6.053 -1.259 1.259
77 PHE 100 ALA 1.187 2.446 -1.259 1.259
260 ILE 284 LEU 4.114 2.855 1.258 1.258
230 LEU 253 LEU 4.427 3.170 1.257 1.257
553 LEU 557 LEU 0.000 1.253 -1.253 1.253
323 SER 345 LEU 0.000 1.251 -1.251 1.251
312 PHE 358 LEU 1.246 0.000 1.246 1.246
284 LEU 306 ALA 1.192 2.438 -1.245 1.245
91 ASN 114 ASN 1.521 2.766 -1.244 1.244
301 LEU 321 LEU 0.000 1.236 -1.236 1.236
240 PHE 264 PRO 1.578 2.813 -1.235 1.235
613 GLU 689 ALA 0.105 1.339 -1.234 1.234
416 THR 436 LEU 2.571 3.803 -1.232 1.232
622 GLY 687 TYR 8.931 7.701 1.230 1.230
762 PRO 789 PHE 0.689 1.918 -1.229 1.229
133 SER 155 LEU 0.000 1.228 -1.228 1.228
634 PHE 713 LEU 1.946 0.723 1.223 1.223
154 GLN 178 THR 0.000 1.223 -1.223 1.223
141 ILE 189 ILE 1.220 0.000 1.220 1.220
95 PHE 117 LEU 1.223 0.005 1.218 1.218
537 GLY 542 ARG 1.305 0.088 1.216 1.216
312 PHE 324 LEU 0.000 1.209 -1.209 1.209
565 ALA 818 ARG 0.923 2.132 -1.209 1.209
257 SER 282 ASN 1.947 0.742 1.204 1.204
759 PHE 796 LEU 3.178 1.974 1.204 1.204
128 LEU 176 LEU 1.202 0.000 1.202 1.202
161 ASP 187 ASN 0.000 1.199 -1.199 1.199
42 ASP 63 ASP 3.370 2.171 1.199 1.199
643 ARG 745 MET 0.000 1.196 -1.196 1.196
346 ARG 368 GLU 8.004 6.809 1.195 1.195
142 THR 165 LEU 0.000 1.195 -1.195 1.195
48 LEU 67 ASN 10.955 9.760 1.195 1.195
64 ILE 87 GLN 3.957 5.148 -1.190 1.190
101 LEU 124 ALA 2.928 1.740 1.187 1.187
636 LEU 797 ASN 1.181 0.000 1.181 1.181
428 PHE 451 LEU 1.334 0.165 1.169 1.169
160 LEU 184 LEU 0.000 1.166 -1.166 1.166
690 SER 696 PHE 3.731 2.566 1.166 1.166
529 PHE 690 SER 0.211 1.376 -1.166 1.166
463 SER 523 THR 5.027 6.186 -1.160 1.160
434 ASN 457 VAL 0.227 1.385 -1.159 1.159
313 PRO 350 LEU 1.158 0.000 1.158 1.158
558 LEU 808 PHE 0.000 1.158 -1.158 1.158
360 SER 383 GLY 2.408 3.565 -1.157 1.157
334 ILE 355 ILE 0.000 1.155 -1.155 1.155
233 ASN 258 ASN 1.933 0.783 1.150 1.150
149 PHE 152 LEU 0.000 1.150 -1.150 1.150
346 ARG 366 ALA 2.154 3.304 -1.150 1.150
687 TYR 693 CYS 6.571 5.428 1.142 1.142
51 VAL 77 PHE 1.378 2.521 -1.142 1.142
803 PHE 804 PHE 0.000 1.142 -1.142 1.142
332 SER 356 ARG 0.000 1.137 -1.137 1.137
133 SER 179 LEU 1.135 0.000 1.135 1.135
244 ILE 271 ASN 4.919 6.046 -1.128 1.128
193 PRO 220 CYS 2.653 3.780 -1.127 1.127
402 HIS 426 THR 2.252 1.125 1.127 1.127
397 SER 419 ASP 3.071 4.198 -1.127 1.127
390 SER 414 PRO 0.000 1.125 -1.125 1.125
195 PHE 198 THR 2.042 0.927 1.114 1.114
321 LEU 324 LEU 0.329 1.442 -1.113 1.113
334 ILE 335 PRO 0.260 1.372 -1.112 1.112
397 SER 421 SER 4.652 5.764 -1.112 1.112
185 ALA 211 ASN 2.551 1.441 1.110 1.110
234 TYR 258 ASN 1.644 0.534 1.109 1.109
536 LEU 598 ASP 9.114 8.005 1.109 1.109
364 CYS 388 LEU 2.763 1.655 1.108 1.108
118 LYS 141 ILE 3.091 4.198 -1.107 1.107
209 HIS 235 ASN 0.000 1.097 -1.097 1.097
180 GLN 203 LEU 3.414 4.509 -1.095 1.095
637 MET 721 MET 2.445 3.535 -1.090 1.090
92 ASP 115 ASN 0.000 1.089 -1.089 1.089
914 SER 915 PHE 0.000 1.084 -1.084 1.084
687 TYR 695 PRO 2.108 1.024 1.083 1.083
274 LEU 277 ILE 2.075 0.994 1.081 1.081
471 CYS 532 CYS 7.372 6.292 1.081 1.081
271 ASN 274 LEU 0.621 1.698 -1.077 1.077
336 ASN 337 ASN 1.076 0.000 1.076 1.076
136 LEU 160 LEU 0.000 1.074 -1.074 1.074
268 PHE 274 LEU 0.650 1.724 -1.074 1.074
555 PHE 795 CYS 1.073 0.000 1.073 1.073
416 THR 437 ASN 5.858 6.930 -1.072 1.072
169 PRO 173 LEU 0.000 1.070 -1.070 1.070
354 ASN 375 ASN 0.748 1.818 -1.070 1.070
310 GLN 332 SER 0.000 1.069 -1.069 1.069
755 THR 800 LEU 2.496 1.427 1.069 1.069
292 PHE 342 GLN 1.068 0.000 1.068 1.068
149 PHE 175 ASN 0.000 1.067 -1.067 1.067
268 PHE 291 ALA 3.793 2.727 1.066 1.066
886 VAL 887 ALA 1.065 0.000 1.065 1.065
116 GLN 139 ASN 2.191 1.127 1.063 1.063
725 TYR 728 LEU 0.000 1.061 -1.061 1.061
70 THR 92 ASP 3.844 4.904 -1.060 1.060
255 PHE 260 ILE 2.232 1.173 1.059 1.059
546 TRP 596 PHE 1.058 0.000 1.058 1.058
720 LEU 724 ILE 1.056 0.000 1.056 1.056
732 LEU 745 MET 1.052 0.000 1.052 1.052
309 VAL 355 ILE 1.051 0.000 1.051 1.051
312 PHE 326 LEU 0.000 1.049 -1.049 1.049
213 ILE 237 LEU 2.616 3.661 -1.044 1.044
427 SER 449 GLU 0.958 2.000 -1.043 1.043
43 CYS 63 ASP 4.060 5.102 -1.041 1.041
437 ASN 460 ARG 4.251 5.291 -1.041 1.041
643 ARG 746 ILE 0.000 1.041 -1.041 1.041
451 LEU 456 PHE 1.458 0.418 1.040 1.040
659 LEU 663 ARG 1.438 2.477 -1.040 1.040
694 LEU 696 PHE 1.117 2.156 -1.039 1.039
636 LEU 756 ASN 0.000 1.037 -1.037 1.037
554 PHE 555 PHE 1.972 3.009 -1.037 1.037
98 PRO 121 PRO 1.035 0.000 1.035 1.035
292 PHE 303 ILE 0.393 1.427 -1.033 1.033
732 LEU 737 LEU 1.294 0.262 1.032 1.032
125 ILE 149 PHE 0.000 1.032 -1.032 1.032
501 ALA 502 ASP 0.000 1.031 -1.031 1.031
531 PRO 783 LYS 0.000 1.030 -1.030 1.030
49 THR 69 ILE 1.432 2.459 -1.028 1.028
57 ALA 79 ASN 1.940 2.966 -1.026 1.026
636 LEU 721 MET 1.560 2.586 -1.026 1.026
642 GLU 662 PHE 7.946 8.971 -1.025 1.025
252 GLU 276 THR 3.059 2.035 1.024 1.024
548 ILE 792 LEU 0.000 1.023 -1.023 1.023
680 PRO 706 PHE 2.820 3.840 -1.020 1.020
253 LEU 278 HIS 3.985 2.966 1.019 1.019
89 ALA 115 ASN 0.000 1.017 -1.017 1.017
229 THR 252 GLU 6.293 5.278 1.014 1.014
667 LEU 671 LEU 1.014 0.000 1.014 1.014
110 LEU 112 LEU 0.723 1.736 -1.013 1.013
373 GLN 374 ARG 1.013 0.000 1.013 1.013
867 THR 868 LYS 0.000 1.010 -1.010 1.010
162 ASP 163 ASN 1.010 0.000 1.010 1.010
157 HIS 158 LEU 1.007 0.000 1.007 1.007
179 LEU 203 LEU 4.524 5.530 -1.007 1.007
197 PHE 206 LEU 0.825 1.831 -1.006 1.006
449 GLU 469 GLN 2.135 3.140 -1.005 1.005
66 MET 91 ASN 1.390 0.387 1.003 1.003
467 ALA 530 LYS 0.000 1.001 -1.001 1.001
605 PHE 691 PRO 1.286 2.286 -1.000 1.000
169 PRO 172 PRO 0.000 0.999 -0.999 0.999
536 LEU 783 LYS 0.999 0.000 0.999 0.999
335 PRO 337 ASN 0.000 0.999 -0.999 0.999
289 ASN 312 PHE 0.000 0.997 -0.997 0.997
186 LEU 209 HIS 1.862 2.857 -0.995 0.995
152 LEU 153 VAL 0.995 0.000 0.995 0.995
530 LYS 613 GLU 4.953 5.947 -0.994 0.994
240 PHE 244 ILE 0.503 1.493 -0.991 0.991
566 SER 818 ARG 0.000 0.987 -0.987 0.987
60 GLN 84 GLU 5.659 4.672 0.987 0.987
70 THR 94 SER 4.496 3.510 0.986 0.986
915 PHE 916 VAL 0.000 0.984 -0.984 0.984
183 THR 207 HIS 5.233 4.249 0.984 0.984
425 LEU 446 LYS 4.480 3.497 0.983 0.983
640 THR 721 MET 2.202 3.183 -0.981 0.981
692 LEU 787 LEU 1.422 2.402 -0.980 0.980
203 LEU 227 LEU 4.382 5.360 -0.978 0.978
385 PHE 408 ALA 1.776 0.798 0.978 0.978
64 ILE 67 ASN 1.436 0.458 0.977 0.977
192 ILE 220 CYS 1.260 2.237 -0.977 0.977
376 GLN 399 ASN 0.494 1.467 -0.973 0.973
404 ILE 409 PHE 1.028 2.001 -0.973 0.973
186 LEU 211 ASN 1.414 0.442 0.972 0.972
545 VAL 595 THR 2.033 1.063 0.970 0.970
577 ILE 748 HIS 0.000 0.968 -0.968 0.968
637 MET 720 LEU 1.043 0.076 0.967 0.967
729 TYR 750 ALA 0.000 0.967 -0.967 0.967
274 LEU 297 ASP 2.698 3.663 -0.965 0.965
532 CYS 604 ARG 0.000 0.964 -0.964 0.964
105 LYS 129 SER 0.963 0.000 0.963 0.963
457 VAL 479 TYR 0.960 0.000 0.960 0.960
718 PHE 753 ILE 1.246 0.291 0.955 0.955
251 LYS 276 THR 3.149 2.194 0.955 0.955
129 SER 153 VAL 0.000 0.952 -0.952 0.952
144 VAL 145 PRO 1.534 0.583 0.952 0.952
339 CYS 363 GLY 3.516 2.565 0.952 0.952
420 VAL 423 ASN 1.233 0.284 0.949 0.949
881 CYS 882 PRO 0.415 1.362 -0.946 0.946
576 PHE 642 GLU 1.875 2.820 -0.945 0.945
137 ASP 183 THR 0.943 0.000 0.943 0.943
298 LEU 318 THR 0.000 0.938 -0.938 0.938
468 TYR 530 LYS 5.867 4.930 0.937 0.937
179 LEU 182 LEU 0.056 0.992 -0.936 0.936
708 VAL 771 LEU 1.504 0.568 0.936 0.936
193 PRO 217 SER 3.421 2.487 0.935 0.935
300 SER 345 LEU 0.934 0.000 0.934 0.934
134 LEU 149 PHE 0.000 0.932 -0.932 0.932
48 LEU 69 ILE 1.661 2.593 -0.932 0.932
374 ARG 399 ASN 1.546 0.614 0.932 0.932
577 ILE 745 MET 0.000 0.930 -0.930 0.930
74 GLU 99 LYS 7.560 6.630 0.930 0.930
360 SER 384 THR 2.864 1.935 0.929 0.929
601 SER 608 PHE 1.464 0.537 0.927 0.927
587 MET 625 ALA 0.317 1.243 -0.926 0.926
435 GLY 458 ASN 1.378 2.300 -0.922 0.922
434 ASN 455 ASP 1.215 2.135 -0.920 0.920
566 SER 574 LYS 0.918 0.000 0.918 0.918
287 VAL 303 ILE 0.000 0.918 -0.918 0.918
385 PHE 409 PHE 2.029 1.114 0.916 0.916
268 PHE 277 ILE 0.944 1.857 -0.913 0.913
99 LYS 102 SER 1.260 0.348 0.912 0.912
195 PHE 219 HIS 3.443 4.355 -0.912 0.912
221 PHE 243 ALA 2.798 1.888 0.910 0.910
289 ASN 315 LEU 0.907 0.000 0.907 0.907
168 VAL 189 ILE 0.000 0.905 -0.905 0.905
292 PHE 314 ASN 0.000 0.904 -0.904 0.904
114 ASN 138 ALA 4.529 5.430 -0.901 0.901
887 ALA 888 SER 0.000 0.898 -0.898 0.898
319 VAL 342 GLN 0.000 0.898 -0.898 0.898
248 PRO 270 GLY 0.992 1.889 -0.897 0.897
718 PHE 756 ASN 2.673 3.566 -0.893 0.893
218 GLN 219 HIS 2.282 3.174 -0.891 0.891
240 PHE 260 ILE 0.573 1.462 -0.889 0.889
716 LEU 720 LEU 0.000 0.887 -0.887 0.887
62 LEU 64 ILE 1.729 0.843 0.886 0.886
422 PHE 442 VAL 4.048 3.162 0.886 0.886
110 LEU 135 ARG 3.629 2.745 0.884 0.884
430 THR 456 PHE 0.573 1.457 -0.884 0.884
808 PHE 812 TRP 0.039 0.922 -0.883 0.883
152 LEU 176 LEU 0.000 0.882 -0.882 0.882
255 PHE 279 LEU 3.776 2.896 0.880 0.880
718 PHE 757 CYS 4.595 3.717 0.878 0.878
319 VAL 320 HIS 2.566 1.690 0.876 0.876
255 PHE 277 ILE 0.000 0.872 -0.872 0.872
392 ARG 415 ILE 2.460 3.330 -0.870 0.870
448 LYS 610 ILE 2.102 2.972 -0.870 0.870
409 PHE 432 GLY 2.013 1.143 0.870 0.870
558 LEU 803 PHE 0.870 0.000 0.870 0.870
319 VAL 341 GLU 0.000 0.870 -0.870 0.870
423 ASN 444 ASN 8.425 9.293 -0.867 0.867
312 PHE 355 ILE 0.866 0.000 0.866 0.866
113 GLN 139 ASN 0.672 1.538 -0.866 0.866
442 VAL 465 PRO 0.123 0.988 -0.865 0.865
313 PRO 338 LEU 0.863 0.000 0.863 0.863
564 PHE 570 LEU 0.036 0.897 -0.861 0.861
420 VAL 440 LYS 3.454 4.315 -0.861 0.861
290 SER 317 GLY 0.861 0.000 0.861 0.861
328 GLY 351 SER 0.000 0.857 -0.857 0.857
184 LEU 207 HIS 4.217 3.362 0.855 0.855
573 SER 745 MET 0.000 0.855 -0.855 0.855
686 GLU 694 LEU 1.038 0.184 0.854 0.854
686 GLU 702 PRO 0.265 1.118 -0.854 0.854
421 SER 422 PHE 1.326 2.179 -0.853 0.853
392 ARG 414 PRO 0.030 0.880 -0.850 0.850
59 THR 83 LEU 3.233 4.079 -0.847 0.847
35 CYS 40 ARG 1.512 2.358 -0.846 0.846
209 HIS 231 ASP 5.934 6.779 -0.845 0.845
265 ASP 291 ALA 1.661 0.817 0.844 0.844
444 ASN 465 PRO 3.298 2.454 0.843 0.843
349 ASP 371 SER 6.560 5.719 0.841 0.841
334 ILE 338 LEU 0.000 0.840 -0.840 0.840
59 THR 80 PHE 1.136 0.299 0.836 0.836
584 ASN 628 SER 0.000 0.836 -0.836 0.836
238 GLY 260 ILE 1.107 1.943 -0.835 0.835
238 GLY 261 SER 1.648 0.813 0.835 0.835
725 TYR 752 LEU 0.835 0.000 0.835 0.835
305 GLY 351 SER 0.834 0.000 0.834 0.834
416 THR 417 ASN 2.189 3.022 -0.833 0.833
643 ARG 725 TYR 1.740 2.572 -0.832 0.832
48 LEU 52 PRO 1.530 0.699 0.831 0.831
536 LEU 595 THR 0.830 0.000 0.830 0.830
10 PHE 11 LEU 0.829 0.000 0.829 0.829
587 MET 791 PRO 1.458 2.286 -0.828 0.828
184 LEU 189 ILE 0.324 1.149 -0.825 0.825
529 PHE 689 ALA 0.819 0.000 0.819 0.819
729 TYR 747 LYS 0.000 0.818 -0.818 0.818
757 CYS 761 CYS 1.001 0.183 0.818 0.818
657 ASN 659 LEU 0.000 0.818 -0.818 0.818
466 TYR 614 THR 0.000 0.817 -0.817 0.817
641 VAL 662 PHE 0.000 0.816 -0.816 0.816
412 LEU 432 GLY 0.173 0.988 -0.815 0.815
139 ASN 141 ILE 1.467 0.653 0.815 0.815
534 TYR 603 GLY 3.003 3.818 -0.814 0.814
885 ALA 886 VAL 0.811 0.000 0.811 0.811
644 SER 648 LYS 0.437 1.247 -0.811 0.811
470 CYS 526 THR 0.000 0.806 -0.806 0.806
171 HIS 172 PRO 0.084 0.889 -0.805 0.805
409 PHE 429 PRO 1.992 1.187 0.804 0.804
640 THR 724 ILE 2.339 1.535 0.804 0.804
343 LYS 366 ALA 1.532 0.729 0.803 0.803
428 PHE 439 LEU 1.064 1.866 -0.802 0.802
255 PHE 282 ASN 2.441 3.242 -0.801 0.801
633 ILE 718 PHE 0.000 0.801 -0.801 0.801
535 LEU 594 LEU 1.269 0.470 0.798 0.798
533 GLU 601 SER 0.000 0.798 -0.798 0.798
436 LEU 458 ASN 3.920 3.123 0.797 0.797
544 THR 788 ILE 0.085 0.879 -0.794 0.794
338 LEU 339 CYS 0.789 0.000 0.789 0.789
104 LEU 128 LEU 2.217 1.430 0.787 0.787
690 SER 691 PRO 0.985 1.771 -0.787 0.787
572 SER 659 LEU 2.584 1.799 0.786 0.786
536 LEU 542 ARG 2.281 1.497 0.784 0.784
295 LEU 317 GLY 0.000 0.784 -0.784 0.784
131 LEU 152 LEU 0.000 0.783 -0.783 0.783
240 PHE 267 ALA 3.900 4.683 -0.783 0.783
173 LEU 197 PHE 0.000 0.782 -0.782 0.782
222 ASP 246 ALA 0.766 1.547 -0.781 0.781
112 LEU 135 ARG 4.014 4.795 -0.781 0.781
676 ALA 706 PHE 2.330 1.549 0.780 0.780
203 LEU 226 ASN 2.984 3.763 -0.779 0.779
144 VAL 149 PHE 0.000 0.779 -0.779 0.779
219 HIS 222 ASP 5.951 6.729 -0.778 0.778
372 LEU 377 ILE 0.422 1.200 -0.777 0.777
755 THR 756 ASN 0.000 0.777 -0.777 0.777
418 LEU 420 VAL 1.384 0.607 0.777 0.777
338 LEU 342 GLN 0.000 0.776 -0.776 0.776
217 SER 220 CYS 0.939 0.163 0.776 0.776
69 ILE 93 LEU 3.947 4.721 -0.775 0.775
911 GLU 912 GLU 0.127 0.900 -0.774 0.774
698 THR 700 GLU 0.771 0.000 0.771 0.771
766 PHE 781 ILE 0.472 1.239 -0.767 0.767
279 LEU 292 PHE 0.017 0.783 -0.766 0.766
725 TYR 729 TYR 0.000 0.766 -0.766 0.766
115 ASN 117 LEU 0.957 0.193 0.764 0.764
247 LEU 270 GLY 0.910 1.673 -0.763 0.763
424 GLU 444 ASN 0.812 1.575 -0.763 0.763
462 LEU 523 THR 4.095 4.858 -0.763 0.763
380 ILE 384 THR 1.238 0.477 0.760 0.760
301 LEU 345 LEU 0.757 0.000 0.757 0.757
290 SER 316 THR 0.757 0.000 0.757 0.757
778 SER 780 GLU 2.543 1.786 0.756 0.756
134 LEU 136 LEU 1.033 1.789 -0.756 0.756
738 SER 741 SER 0.754 0.000 0.754 0.754
563 THR 578 GLY 0.652 1.406 -0.754 0.754
826 VAL 827 SER 0.000 0.754 -0.754 0.754
687 TYR 694 LEU 0.926 0.175 0.751 0.751
399 ASN 423 ASN 8.075 8.824 -0.749 0.749
172 PRO 198 THR 0.748 0.000 0.748 0.748
889 CYS 890 GLN 2.633 1.885 0.747 0.747
75 ASP 99 LYS 2.641 3.387 -0.746 0.746
240 PHE 262 VAL 1.715 0.971 0.744 0.744
152 LEU 155 LEU 0.000 0.743 -0.743 0.743
737 LEU 745 MET 0.742 0.000 0.742 0.742
140 HIS 187 ASN 0.739 0.000 0.739 0.739
559 VAL 803 PHE 0.737 0.000 0.737 0.737
537 GLY 783 LYS 0.736 0.000 0.736 0.736
238 GLY 258 ASN 0.734 0.000 0.734 0.734
316 THR 338 LEU 0.733 0.000 0.733 0.733
233 ASN 234 TYR 1.104 0.371 0.733 0.733
325 THR 327 THR 0.000 0.733 -0.733 0.733
208 LEU 231 ASP 3.973 4.705 -0.731 0.731
760 PHE 764 ALA 1.962 1.232 0.731 0.731
582 VAL 586 PHE 1.234 0.505 0.729 0.729
626 VAL 695 PRO 0.807 0.079 0.728 0.728

RRCS change distribution

-0.23
Mean ΔRRCS
1.86
Std Dev
-0.07
Median

Magnitude classification

72
High (|Δ| ≥ 5.0)
239
Medium (2.6 ≤ |Δ| < 5.0)
2179
Low (|Δ| < 2.6)

Methods

RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).

Significance threshold. |ΔRRCS| ≥ 2.62, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.

Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.

Structural annotation. TM domain boundaries and generic numbering from GPCRdb.

What is RRCS?

Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.

ΔRRCS (Delta RRCS) shows the difference in contact strength between states:

  • Positive ΔRRCS. Contact is stronger in the active state.
  • Negative ΔRRCS. Contact is stronger in the inactive state.
  • Large |ΔRRCS|. Significant structural rearrangement.

Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.

Pathogenicity predictions

AlphaMissense predicts whether a mutation harms protein function:

  • Pathogenic (score ≥ 0.564): mutation likely damages function.
  • Ambiguous (0.34–0.563): effect uncertain.
  • Benign (< 0.34): mutation likely tolerated.

Conservation & population data

Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.

Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.

Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar