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LGR6

Gene LGR6 Class A orphans Orphan receptors UniProt Q9HBX8
UniProt ↗ GPCRdb ↗ NCBI Gene ↗
2382
Total Contact Pairs
275
Significant Changes
10.58
Max Increase
-10.62
Max Decrease

Interactive snake plot

GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.

Color convention: blue = active-favoring, red = inactive-favoring.

ICL1 G590 G590 G P591 P591 P V592 V592 V P593 P593 P L594 L594 L ICL1ECL1 F626 F626 F G627 G627 G Q628 Q628 Q F629 F629 F S630 S630 S E631 E631 E Y632 Y632 Y G633 G633 G A634 A634 A ECL1ICL2 V674 34.50x50 V674 34.50x50 V R675 34.51x51 R675 34.51x51 R A676 34.52x52 A676 34.52x52 A Y677 34.53x53 Y677 34.53x53 Y G678 34.54x54 G678 34.54x54 G K679 34.55x55 K679 34.55x55 K S680 34.56x56 S680 34.56x56 S P681 34.57x57 P681 34.57x57 P ICL2ECL2 V708 V708 V G709 G709 G E710 E710 E Y711 Y711 Y G712 G712 G A713 A713 A S714 S714 S P715 P715 P L716 L716 L C717 45.50x50 C717 45.50x50 C L718 45.51x51 L718 45.51x51 L P719 45.52x52 P719 45.52x52 P Y720 Y720 Y A721 A721 A P722 P722 P P723 P723 P E724 E724 E G725 G725 G Q726 Q726 Q P727 P727 P ECL2ICL3 G761 G761 G D762 D762 D F763 F763 F E764 E764 E A765 A765 A ICL3ECL3 L800 L800 L F801 F801 F P802 P802 P V803 V803 V T804 T804 T ECL3N-term M1 M1 M P2 P2 P S3 S3 S P4 P4 P P5 P5 P G6 G6 G L7 L7 L R8 R8 R A9 A9 A L10 L10 L W11 W11 W L12 L12 L C13 C13 C A14 A14 A A15 A15 A L16 L16 L C17 C17 C A18 A18 A S19 S19 S R20 R20 R R21 R21 R A22 A22 A G23 G23 G G24 G24 G A25 A25 A P26 P26 P Q27 Q27 Q P28 P28 P G29 G29 G P30 P30 P G31 G31 G P32 P32 P T33 T33 T A34 A34 A C35 C35 C P36 P36 P A37 A37 A P38 P38 P C39 C39 C H40 H40 H C41 C41 C Q42 Q42 Q E43 E43 E D44 D44 D G45 G45 G I46 I46 I M47 M47 M L48 L48 L S49 S49 S A50 A50 A D51 D51 D C52 C52 C S53 S53 S E54 E54 E L55 L55 L G56 G56 G L57 L57 L S58 S58 S A59 A59 A V60 V60 V P61 P61 P G62 G62 G D63 D63 D L64 L64 L D65 D65 D P66 P66 P L67 L67 L T68 T68 T A69 A69 A Y70 Y70 Y L71 L71 L D72 D72 D L73 L73 L S74 S74 S M75 M75 M N76 N76 N N77 N77 N L78 L78 L T79 T79 T E80 E80 E L81 L81 L Q82 Q82 Q P83 P83 P G84 G84 G L85 L85 L F86 F86 F H87 H87 H H88 H88 H L89 L89 L R90 R90 R F91 F91 F L92 L92 L E93 E93 E E94 E94 E L95 L95 L R96 R96 R L97 L97 L S98 S98 S G99 G99 G N100 N100 N H101 H101 H L102 L102 L S103 S103 S H104 H104 H I105 I105 I P106 P106 P G107 G107 G Q108 Q108 Q A109 A109 A F110 F110 F S111 S111 S G112 G112 G L113 L113 L Y114 Y114 Y S115 S115 S L116 L116 L K117 K117 K I118 I118 I L119 L119 L M120 M120 M L121 L121 L Q122 Q122 Q N123 N123 N N124 N124 N Q125 Q125 Q L126 L126 L G127 G127 G G128 G128 G I129 I129 I P130 P130 P A131 A131 A E132 E132 E A133 A133 A L134 L134 L W135 W135 W E136 E136 E L137 L137 L P138 P138 P S139 S139 S L140 L140 L Q141 Q141 Q S142 S142 S L143 L143 L R144 R144 R L145 L145 L D146 D146 D A147 A147 A N148 N148 N L149 L149 L I150 I150 I S151 S151 S L152 L152 L V153 V153 V P154 P154 P E155 E155 E R156 R156 R S157 S157 S F158 F158 F E159 E159 E G160 G160 G L161 L161 L S162 S162 S S163 S163 S L164 L164 L R165 R165 R H166 H166 H L167 L167 L W168 W168 W L169 L169 L D170 D170 D D171 D171 D N172 N172 N A173 A173 A L174 L174 L T175 T175 T E176 E176 E I177 I177 I P178 P178 P V179 V179 V R180 R180 R A181 A181 A L182 L182 L N183 N183 N N184 N184 N L185 L185 L P186 P186 P A187 A187 A L188 L188 L Q189 Q189 Q A190 A190 A M191 M191 M T192 T192 T L193 L193 L A194 A194 A L195 L195 L N196 N196 N R197 R197 R I198 I198 I S199 S199 S H200 H200 H I201 I201 I P202 P202 P D203 D203 D Y204 Y204 Y A205 A205 A F206 F206 F Q207 Q207 Q N208 N208 N L209 L209 L T210 T210 T S211 S211 S L212 L212 L V213 V213 V V214 V214 V L215 L215 L H216 H216 H L217 L217 L H218 H218 H N219 N219 N N220 N220 N R221 R221 R I222 I222 I Q223 Q223 Q H224 H224 H L225 L225 L G226 G226 G T227 T227 T H228 H228 H S229 S229 S F230 F230 F E231 E231 E G232 G232 G L233 L233 L H234 H234 H N235 N235 N L236 L236 L E237 E237 E T238 T238 T L239 L239 L D240 D240 D L241 L241 L N242 N242 N Y243 Y243 Y N244 N244 N K245 K245 K L246 L246 L Q247 Q247 Q E248 E248 E F249 F249 F P250 P250 P V251 V251 V A252 A252 A I253 I253 I R254 R254 R T255 T255 T L256 L256 L G257 G257 G R258 R258 R L259 L259 L Q260 Q260 Q E261 E261 E L262 L262 L G263 G263 G F264 F264 F H265 H265 H N266 N266 N N267 N267 N N268 N268 N I269 I269 I K270 K270 K A271 A271 A I272 I272 I P273 P273 P E274 E274 E K275 K275 K A276 A276 A F277 F277 F M278 M278 M G279 G279 G N280 N280 N P281 P281 P L282 L282 L L283 L283 L Q284 Q284 Q T285 T285 T I286 I286 I H287 H287 H F288 F288 F Y289 Y289 Y D290 D290 D N291 N291 N P292 P292 P I293 I293 I Q294 Q294 Q F295 F295 F V296 V296 V G297 G297 G R298 R298 R S299 S299 S A300 A300 A F301 F301 F Q302 Q302 Q Y303 Y303 Y L304 L304 L P305 P305 P K306 K306 K L307 L307 L H308 H308 H T309 T309 T L310 L310 L S311 S311 S L312 L312 L N313 N313 N G314 G314 G A315 A315 A M316 M316 M D317 D317 D I318 I318 I Q319 Q319 Q E320 E320 E F321 F321 F P322 P322 P D323 D323 D L324 L324 L K325 K325 K G326 G326 G T327 T327 T T328 T328 T S329 S329 S L330 L330 L E331 E331 E I332 I332 I L333 L333 L T334 T334 T L335 L335 L T336 T336 T R337 R337 R A338 A338 A G339 G339 G I340 I340 I R341 R341 R L342 L342 L L343 L343 L P344 P344 P S345 S345 S G346 G346 G M347 M347 M C348 C348 C Q349 Q349 Q Q350 Q350 Q L351 L351 L P352 P352 P R353 R353 R L354 L354 L R355 R355 R V356 V356 V L357 L357 L E358 E358 E L359 L359 L S360 S360 S H361 H361 H N362 N362 N Q363 Q363 Q I364 I364 I E365 E365 E E366 E366 E L367 L367 L P368 P368 P S369 S369 S L370 L370 L H371 H371 H R372 R372 R C373 C373 C Q374 Q374 Q K375 K375 K L376 L376 L E377 E377 E E378 E378 E I379 I379 I G380 G380 G L381 L381 L Q382 Q382 Q H383 H383 H N384 N384 N R385 R385 R I386 I386 I W387 W387 W E388 E388 E I389 I389 I G390 G390 G A391 A391 A D392 D392 D T393 T393 T F394 F394 F S395 S395 S Q396 Q396 Q L397 L397 L S398 S398 S S399 S399 S L400 L400 L Q401 Q401 Q A402 A402 A L403 L403 L D404 D404 D L405 L405 L S406 S406 S W407 W407 W N408 N408 N A409 A409 A I410 I410 I R411 R411 R S412 S412 S I413 I413 I H414 H414 H P415 P415 P E416 E416 E A417 A417 A F418 F418 F S419 S419 S T420 T420 T L421 L421 L H422 H422 H S423 S423 S L424 L424 L V425 V425 V K426 K426 K L427 L427 L D428 D428 D L429 L429 L T430 T430 T D431 D431 D N432 N432 N Q433 Q433 Q L434 L434 L T435 T435 T T436 T436 T L437 L437 L P438 P438 P L439 L439 L A440 A440 A G441 G441 G L442 L442 L G443 G443 G G444 G444 G L445 L445 L M446 M446 M H447 H447 H L448 L448 L K449 K449 K L450 L450 L K451 K451 K G452 G452 G N453 N453 N L454 L454 L A455 A455 A L456 L456 L S457 S457 S Q458 Q458 Q A459 A459 A F460 F460 F S461 S461 S K462 K462 K D463 D463 D S464 S464 S F465 F465 F P466 P466 P K467 K467 K L468 L468 L R469 R469 R I470 I470 I L471 L471 L E472 E472 E V473 V473 V P474 P474 P Y475 Y475 Y A476 A476 A Y477 Y477 Y Q478 Q478 Q C479 C479 C C480 C480 C P481 P481 P Y482 Y482 Y G483 G483 G M484 M484 M C485 C485 C A486 A486 A S487 S487 S F488 F488 F F489 F489 F K490 K490 K A491 A491 A S492 S492 S G493 G493 G Q494 Q494 Q W495 W495 W E496 E496 E A497 A497 A E498 E498 E D499 D499 D L500 L500 L H501 H501 H L502 L502 L D503 D503 D D504 D504 D E505 E505 E E506 E506 E S507 S507 S S508 S508 S K509 K509 K R510 R510 R P511 P511 P L512 L512 L G513 G513 G L514 L514 L L515 L515 L A516 A516 A R517 R517 R Q518 Q518 Q A519 A519 A E520 E520 E N521 N521 N H522 H522 H Y523 Y523 Y D524 D524 D Q525 Q525 Q D526 D526 D L527 L527 L D528 D528 D E529 E529 E L530 L530 L Q531 Q531 Q L532 L532 L E533 E533 E M534 M534 M E535 E535 E D536 D536 D S537 S537 S K538 K538 K P539 P539 P H540 H540 H P541 P541 P S542 S542 S V543 V543 V Q544 Q544 Q C545 C545 C S546 S546 S P547 P547 P T548 T548 T P549 P549 P G550 G550 G P551 P551 P F552 F552 F K553 K553 K P554 P554 P C555 C555 C E556 E556 E Y557 Y557 Y L558 L558 L F559 F559 F E560 E560 E N-termC-term G846 G846 G D847 D847 D S848 S848 S G849 G849 G P850 P850 P L851 L851 L A852 A852 A Y853 Y853 Y A854 A854 A A855 A855 A A856 A856 A G857 G857 G E858 E858 E L859 L859 L E860 E860 E K861 K861 K S862 S862 S S863 S863 S C864 C864 C D865 D865 D S866 S866 S T867 T867 T Q868 Q868 Q A869 A869 A L870 L870 L V871 V871 V A872 A872 A F873 F873 F S874 S874 S D875 D875 D V876 V876 V D877 D877 D L878 L878 L I879 I879 I L880 L880 L E881 E881 E A882 A882 A S883 S883 S E884 E884 E A885 A885 A G886 G886 G R887 R887 R P888 P888 P P889 P889 P G890 G890 G L891 L891 L E892 E892 E T893 T893 T Y894 Y894 Y G895 G895 G F896 F896 F P897 P897 P S898 S898 S V899 V899 V T900 T900 T L901 L901 L I902 I902 I S903 S903 S C904 C904 C Q905 Q905 Q Q906 Q906 Q P907 P907 P G908 G908 G A909 A909 A P910 P910 P R911 R911 R L912 L912 L E913 E913 E G914 G914 G S915 S915 S H916 H916 H C917 C917 C V918 V918 V E919 E919 E P920 P920 P E921 E921 E G922 G922 G N923 N923 N H924 H924 H F925 F925 F G926 G926 G N927 N927 N P928 P928 P Q929 Q929 Q P930 P930 P S931 S931 S M932 M932 M D933 D933 D G934 G934 G E935 E935 E L936 L936 L L937 L937 L L938 L938 L R939 R939 R A940 A940 A E941 E941 E G942 G942 G S943 S943 S T944 T944 T P945 P945 P A946 A946 A G947 G947 G G948 G948 G G949 G949 G L950 L950 L S951 S951 S G952 G952 G G953 G953 G G954 G954 G G955 G955 G F956 F956 F Q957 Q957 Q P958 P958 P S959 S959 S G960 G960 G L961 L961 L A962 A962 A F963 F963 F A964 A964 A S965 S965 S H966 H966 H V967 V967 V C-term S561 1.32x32 S561 1.32x32 S W562 1.33x33 W562 1.33x33 W G563 1.34x34 G563 1.34x34 G I564 1.35x35 I564 1.35x35 I R565 1.36x36 R565 1.36x36 R L566 1.37x37 L566 1.37x37 L A567 1.38x38 A567 1.38x38 A V568 1.39x39 V568 1.39x39 V W569 1.40x40 W569 1.40x40 W A570 1.41x41 A570 1.41x41 A I571 1.42x42 I571 1.42x42 I V572 1.43x43 V572 1.43x43 V L573 1.44x44 L573 1.44x44 L L574 1.45x45 L574 1.45x45 L S575 1.46x46 S575 1.46x46 S V576 1.47x47 V576 1.47x47 V L577 1.48x48 L577 1.48x48 L C578 1.49x49 C578 1.49x49 C N579 1.50x50 N579 1.50x50 N G580 1.51x51 G580 1.51x51 G L581 1.52x52 L581 1.52x52 L V582 1.53x53 V582 1.53x53 V L583 1.54x54 L583 1.54x54 L L584 1.55x55 L584 1.55x55 L T585 1.56x56 T585 1.56x56 T V586 1.57x57 V586 1.57x57 V F587 1.58x58 F587 1.58x58 F A588 1.59x59 A588 1.59x59 A G589 1.60x60 G589 1.60x60 G P595 2.37x37 P595 2.37x37 P P596 2.38x38 P596 2.38x38 P V597 2.39x39 V597 2.39x39 V K598 2.40x40 K598 2.40x40 K F599 2.41x41 F599 2.41x41 F V600 2.42x42 V600 2.42x42 V V601 2.43x43 V601 2.43x43 V G602 2.44x44 G602 2.44x44 G A603 2.45x45 A603 2.45x45 A I604 2.46x46 I604 2.46x46 I A605 2.47x47 A605 2.47x47 A G606 2.48x48 G606 2.48x48 G A607 2.49x49 A607 2.49x49 A N608 2.50x50 N608 2.50x50 N T609 2.51x51 T609 2.51x51 T L610 2.52x52 L610 2.52x52 L T611 2.53x53 T611 2.53x53 T G612 2.54x54 G612 2.54x54 G I613 2.55x55 I613 2.55x55 I S614 2.56x56 S614 2.56x56 S C615 2.57x57 C615 2.57x57 C G616 2.58x58 G616 2.58x58 G L617 2.59x59 L617 2.59x59 L L618 2.60x60 L618 2.60x60 L A619 2.61x61 A619 2.61x61 A S620 2.62x62 S620 2.62x62 S V621 2.63x63 V621 2.63x63 V D622 2.64x64 D622 2.64x64 D A623 2.65x65 A623 2.65x65 A L624 2.66x66 L624 2.66x66 L T625 2.67x67 T625 2.67x67 T R635 3.18x18 R635 3.18x18 R W636 3.19x19 W636 3.19x19 W E637 3.20x20 E637 3.20x20 E T638 3.21x21 T638 3.21x21 T G639 3.22x22 G639 3.22x22 G L640 3.23x23 L640 3.23x23 L G641 3.24x24 G641 3.24x24 G C642 3.25x25 C642 3.25x25 C R643 3.26x26 R643 3.26x26 R A644 3.27x27 A644 3.27x27 A T645 3.28x28 T645 3.28x28 T G646 3.29x29 G646 3.29x29 G F647 3.30x30 F647 3.30x30 F L648 3.31x31 L648 3.31x31 L A649 3.32x32 A649 3.32x32 A V650 3.33x33 V650 3.33x33 V L651 3.34x34 L651 3.34x34 L G652 3.35x35 G652 3.35x35 G S653 3.36x36 S653 3.36x36 S E654 3.37x37 E654 3.37x37 E A655 3.38x38 A655 3.38x38 A S656 3.39x39 S656 3.39x39 S V657 3.40x40 V657 3.40x40 V L658 3.41x41 L658 3.41x41 L L659 3.42x42 L659 3.42x42 L L660 3.43x43 L660 3.43x43 L T661 3.44x44 T661 3.44x44 T L662 3.45x45 L662 3.45x45 L A663 3.46x46 A663 3.46x46 A A664 3.47x47 A664 3.47x47 A V665 3.48x48 V665 3.48x48 V Q666 3.49x49 Q666 3.49x49 Q C667 3.50x50 C667 3.50x50 C S668 3.51x51 S668 3.51x51 S V669 3.52x52 V669 3.52x52 V S670 3.53x53 S670 3.53x53 S V671 3.54x54 V671 3.54x54 V S672 3.55x55 S672 3.55x55 S C673 3.56x56 C673 3.56x56 C S682 4.38x38 S682 4.38x38 S L683 4.39x39 L683 4.39x39 L G684 4.40x40 G684 4.40x40 G S685 4.41x41 S685 4.41x41 S V686 4.42x42 V686 4.42x42 V R687 4.43x43 R687 4.43x43 R A688 4.44x44 A688 4.44x44 A G689 4.45x45 G689 4.45x45 G V690 4.46x46 V690 4.46x46 V L691 4.47x47 L691 4.47x47 L G692 4.48x48 G692 4.48x48 G C693 4.49x49 C693 4.49x49 C L694 4.50x50 L694 4.50x50 L A695 4.51x51 A695 4.51x51 A L696 4.52x52 L696 4.52x52 L A697 4.53x53 A697 4.53x53 A G698 4.54x54 G698 4.54x54 G L699 4.55x55 L699 4.55x55 L A700 4.56x56 A700 4.56x56 A A701 4.57x57 A701 4.57x57 A A702 4.58x58 A702 4.58x58 A L703 4.59x59 L703 4.59x59 L P704 4.60x60 P704 4.60x60 P L705 4.61x61 L705 4.61x61 L A706 4.62x62 A706 4.62x62 A S707 4.63x63 S707 4.63x63 S A728 5.35x35 A728 5.35x35 A A729 5.36x36 A729 5.36x36 A L730 5.37x37 L730 5.37x37 L G731 5.38x38 G731 5.38x38 G F732 5.39x39 F732 5.39x39 F T733 5.40x40 T733 5.40x40 T V734 5.41x41 V734 5.41x41 V A735 5.42x42 A735 5.42x42 A L736 5.43x43 L736 5.43x43 L V737 5.44x44 V737 5.44x44 V M738 5.45x45 M738 5.45x45 M M739 5.46x46 M739 5.46x46 M N740 5.47x47 N740 5.47x47 N S741 5.48x48 S741 5.48x48 S F742 5.49x49 F742 5.49x49 F C743 5.50x50 C743 5.50x50 C F744 5.51x51 F744 5.51x51 F L745 5.52x52 L745 5.52x52 L V746 5.53x53 V746 5.53x53 V V747 5.54x54 V747 5.54x54 V A748 5.55x55 A748 5.55x55 A G749 5.56x56 G749 5.56x56 G A750 5.57x57 A750 5.57x57 A Y751 5.58x58 Y751 5.58x58 Y I752 5.59x59 I752 5.59x59 I K753 5.60x60 K753 5.60x60 K L754 5.61x61 L754 5.61x61 L Y755 5.62x62 Y755 5.62x62 Y C756 5.63x63 C756 5.63x63 C D757 5.64x64 D757 5.64x64 D L758 5.65x65 L758 5.65x65 L P759 5.66x66 P759 5.66x66 P R760 5.67x67 R760 5.67x67 R V766 6.28x28 V766 6.28x28 V W767 6.29x29 W767 6.29x29 W D768 6.30x30 D768 6.30x30 D C769 6.31x31 C769 6.31x31 C A770 6.32x32 A770 6.32x32 A M771 6.33x33 M771 6.33x33 M V772 6.34x34 V772 6.34x34 V R773 6.35x35 R773 6.35x35 R H774 6.36x36 H774 6.36x36 H V775 6.37x37 V775 6.37x37 V A776 6.38x38 A776 6.38x38 A W777 6.39x39 W777 6.39x39 W L778 6.40x40 L778 6.40x40 L I779 6.41x41 I779 6.41x41 I F780 6.42x42 F780 6.42x42 F A781 6.43x43 A781 6.43x43 A D782 6.44x44 D782 6.44x44 D G783 6.45x45 G783 6.45x45 G L784 6.46x46 L784 6.46x46 L L785 6.47x47 L785 6.47x47 L Y786 6.48x48 Y786 6.48x48 Y C787 6.49x49 C787 6.49x49 C P788 6.50x50 P788 6.50x50 P V789 6.51x51 V789 6.51x51 V A790 6.52x52 A790 6.52x52 A F791 6.53x53 F791 6.53x53 F L792 6.54x54 L792 6.54x54 L S793 6.55x55 S793 6.55x55 S F794 6.56x56 F794 6.56x56 F A795 6.57x57 A795 6.57x57 A S796 6.58x58 S796 6.58x58 S M797 6.59x59 M797 6.59x59 M L798 6.60x60 L798 6.60x60 L G799 6.61x61 G799 6.61x61 G P805 7.31x30 P805 7.31x30 P E806 7.32x31 E806 7.32x31 E A807 7.33x32 A807 7.33x32 A V808 7.34x33 V808 7.34x33 V K809 7.35x34 K809 7.35x34 K S810 7.36x35 S810 7.36x35 S V811 7.37x36 V811 7.37x36 V L812 7.38x37 L812 7.38x37 L L813 7.39x38 L813 7.39x38 L V814 7.40x39 V814 7.40x39 V V815 7.41x40 V815 7.41x40 V L816 7.42x41 L816 7.42x41 L P817 7.43x42 P817 7.43x42 P L818 7.44x43 L818 7.44x43 L P819 7.45x45 P819 7.45x45 P A820 7.46x46 A820 7.46x46 A C821 7.47x47 C821 7.47x47 C L822 7.48x48 L822 7.48x48 L N823 7.49x49 N823 7.49x49 N P824 7.50x50 P824 7.50x50 P L825 7.51x51 L825 7.51x51 L L826 7.52x52 L826 7.52x52 L Y827 7.53x53 Y827 7.53x53 Y L828 7.54x54 L828 7.54x54 L L829 7.55x55 L829 7.55x55 L F830 7.56x56 F830 7.56x56 F N831 8.47x47 N831 8.47x47 N P832 8.48x48 P832 8.48x48 P H833 8.49x49 H833 8.49x49 H L838 8.54x54 L838 8.54x54 L R839 8.55x55 R839 8.55x55 R R840 8.56x56 R840 8.56x56 R A845 8.61x61 A845 8.61x61 A F834 8.50x50 F834 8.50x50 F R835 8.51x51 R835 8.51x51 R D836 8.52x52 D836 8.52x52 D D837 8.53x53 D837 8.53x53 D L841 8.57x57 L841 8.57x57 L R842 8.58x58 R842 8.58x58 R P843 8.59x59 P843 8.59x59 P R844 8.60x60 R844 8.60x60 R

Top 100 conformational changes

Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.

Rank Residue 1 Residue 2 Active RRCS Inactive RRCS ΔRRCS Magnitude
1 ASN148 ASN172 0.000 10.623 -10.623 HIGH
2 TRP767 (6.29x29) ALA872 10.584 0.000 +10.584 HIGH
3 ASN172 ASN196 0.000 10.082 -10.082 HIGH
4 HIS308 GLU331 16.118 6.604 +9.514 HIGH
5 ARG165 GLN189 0.000 8.763 -8.763 HIGH
6 ILE150 ASN172 0.000 8.626 -8.626 HIGH
7 GLU560 GLU806 (7.32x31) 8.557 0.000 +8.557 HIGH
8 LEU174 ASN196 0.000 8.491 -8.491 HIGH
9 GLU556 GLY627 0.000 8.388 -8.388 HIGH
10 PHE552 TYR720 0.000 8.247 -8.247 HIGH
11 HIS774 (6.36x36) TYR827 (7.53x53) 0.000 8.243 -8.243 HIGH
12 GLN141 ARG165 0.000 8.053 -8.053 HIGH
13 PHE744 (5.51x51) TYR786 (6.48x48) 0.813 8.705 -7.893 HIGH
14 GLU556 TYR557 0.000 7.842 -7.842 HIGH
15 VAL153 GLU176 7.833 0.000 +7.833 HIGH
16 HIS265 HIS522 7.820 0.000 +7.820 HIGH
17 HIS265 TYR289 12.059 19.649 -7.590 HIGH
18 ASP146 ALA194 7.381 0.000 +7.381 HIGH
19 GLN382 ASP404 2.437 9.810 -7.373 HIGH
20 ASN266 ASP290 3.315 10.467 -7.152 HIGH
21 LEU500 HIS501 8.287 1.259 +7.027 HIGH
22 ALA795 (6.57x57) LEU800 8.113 1.131 +6.982 HIGH
23 SER151 THR175 6.846 0.000 +6.846 HIGH
24 GLU892 THR893 0.592 7.272 -6.680 HIGH
25 ARG144 TRP168 0.000 6.514 -6.514 HIGH
26 CYS555 SER630 0.017 6.502 -6.486 HIGH
27 GLU935 LEU936 0.429 6.779 -6.349 HIGH
28 ASP146 ASP170 0.000 6.330 -6.330 HIGH
29 ARG675 (34.51x51) ASP757 (5.64x64) 2.819 8.970 -6.152 HIGH
30 GLN284 LYS306 3.090 9.093 -6.004 HIGH
31 ILE150 ASN196 5.927 0.000 +5.927 HIGH
32 ARG517 GLN518 0.072 5.945 -5.873 HIGH
33 TRP562 (1.33x33) ARG565 (1.36x36) 0.464 6.302 -5.838 HIGH
34 MET120 GLN122 0.000 5.832 -5.832 HIGH
35 GLY127 THR175 5.820 0.000 +5.820 HIGH
36 TRP135 GLU159 0.000 5.809 -5.809 HIGH
37 LEU174 ARG197 0.000 5.751 -5.751 HIGH
38 ASP72 ARG96 4.600 10.339 -5.740 HIGH
39 ASP170 THR192 0.000 5.631 -5.631 HIGH
40 ASN242 HIS265 11.982 17.569 -5.588 HIGH
41 ARG197 ARG221 0.000 5.586 -5.586 HIGH
42 ILE150 ALA173 0.000 5.571 -5.571 HIGH
43 ALA147 ASP171 0.000 5.557 -5.557 HIGH
44 TYR303 LYS325 2.450 7.936 -5.485 HIGH
45 ASN220 ASN244 3.349 8.779 -5.430 HIGH
46 ASP170 ALA194 0.000 5.384 -5.384 HIGH
47 GLN42 ASP44 5.378 0.000 +5.378 HIGH
48 LEU502 ASP503 0.000 5.332 -5.332 HIGH
49 GLU331 ARG355 12.349 7.025 +5.324 HIGH
50 LEU140 SER163 0.000 5.320 -5.320 HIGH
51 ARG165 LEU188 0.000 5.291 -5.291 HIGH
52 LEU143 TRP168 0.000 5.274 -5.274 HIGH
53 LEU140 LEU164 0.000 5.239 -5.239 HIGH
54 LEU778 (6.40x40) ASN823 (7.49x49) 0.000 5.164 -5.164 HIGH
55 GLU560 LYS809 (7.35x34) 0.236 5.357 -5.120 HIGH
56 ALA315 ARG337 5.575 0.455 +5.120 HIGH
57 HIS287 TYR289 6.291 1.293 +4.999 MED
58 TYR827 (7.53x53) ASN831 (8.47x47) 0.000 4.912 -4.912 MED
59 ARG469 PRO541 0.000 4.878 -4.878 MED
60 LEU140 ALA187 4.869 0.000 +4.869 MED
61 LEU126 LEU149 1.026 5.893 -4.867 MED
62 ALA147 LEU195 4.865 0.000 +4.865 MED
63 LEU703 (4.59x59) VAL708 3.711 8.537 -4.826 MED
64 TYR289 SER311 4.814 0.000 +4.814 MED
65 ARG565 (1.36x36) PHE626 8.580 3.785 +4.795 MED
66 HIS88 LEU89 4.791 0.000 +4.791 MED
67 PHE559 ARG565 (1.36x36) 6.252 1.467 +4.785 MED
68 HIS774 (6.36x36) LEU778 (6.40x40) 0.000 4.727 -4.727 MED
69 SER369 ASP392 3.076 7.785 -4.709 MED
70 GLY56 ASN77 0.426 5.111 -4.686 MED
71 PHE264 PHE288 9.156 4.486 +4.670 MED
72 SER508 LYS509 0.000 4.655 -4.655 MED
73 LEU304 THR327 4.231 8.865 -4.634 MED
74 GLU274 ARG298 1.203 5.800 -4.597 MED
75 SER19 ARG20 0.000 4.588 -4.588 MED
76 TYR751 (5.58x58) ALA776 (6.38x38) 0.000 4.588 -4.588 MED
77 ILE150 ARG197 4.588 0.000 +4.588 MED
78 GLN141 GLN189 4.575 0.000 +4.575 MED
79 LEU145 TRP168 0.000 4.497 -4.497 MED
80 LEU164 LEU188 0.000 4.486 -4.486 MED
81 PRO551 GLU806 (7.32x31) 0.000 4.485 -4.485 MED
82 LEU149 ARG197 4.483 0.000 +4.483 MED
83 HIS774 (6.36x36) LEU826 (7.52x52) 0.000 4.473 -4.473 MED
84 PRO551 LYS809 (7.35x34) 0.000 4.471 -4.471 MED
85 SER151 GLU176 4.464 0.000 +4.464 MED
86 GLU365 ARG385 2.851 7.265 -4.414 MED
87 ASP146 TRP168 0.000 4.397 -4.397 MED
88 LEU140 LEU188 4.386 0.000 +4.386 MED
89 TYR557 PHE626 1.322 5.696 -4.374 MED
90 ARG156 GLU159 0.000 4.337 -4.337 MED
91 GLN141 LEU164 0.000 4.314 -4.314 MED
92 ARG355 GLU377 10.465 14.778 -4.313 MED
93 GLN302 TYR303 8.326 4.036 +4.291 MED
94 ASP240 ASN242 3.072 7.356 -4.284 MED
95 GLU274 GLY297 2.027 6.278 -4.251 MED
96 GLN494 GLU496 4.189 0.000 +4.189 MED
97 SER741 (5.48x48) TYR786 (6.48x48) 9.468 5.318 +4.150 MED
98 TYR243 ASN266 5.988 10.122 -4.134 MED
99 LEU828 (7.54x54) PHE834 (8.50x50) 0.220 4.343 -4.123 MED
100 LEU164 ALA187 0.000 4.083 -4.083 MED

Transmembrane domain analysis

Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.34 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).

Per-segment summary
Segment Range Active-favoring residues Count Inactive-favoring residues Count
TM1 562-565 - 0 562 (-5.8), 565 (-5.8) 2
TM2 - - 0 - 0
TM3 - - 0 - 0
TM4 703-703 - 0 703 (-4.8) 1
TM5 729-757 741 (4.1), 740 (4.0), 729 (3.9), 733 (3.5), 755 (3.5) 5 744 (-7.9), 757 (-6.2), 751 (-4.6) 3
TM6 767-797 767 (10.6), 795 (7.0), 797 (3.5), 772 (3.5) 4 774 (-8.2), 786 (-7.9), 778 (-5.2), 776 (-4.6) 4
TM7 805-828 806 (8.6) 1 827 (-8.2), 823 (-5.2), 809 (-5.1), 826 (-4.5), 828 (-4.1), 805 (-3.2) 6
Intracellular / Extracellular loops & H8
ICL1 - - 0 - 0
ICL2 675-675 - 0 675 (-6.2) 1
ICL3 - - 0 - 0
ECL1 626-631 626 (4.8), 631 (3.0) 2 627 (-8.4), 630 (-6.5), 629 (-3.8) 3
ECL2 708-726 723 (4.0), 726 (4.0), 716 (3.3) 3 720 (-8.2), 708 (-4.8), 710 (-3.2) 3
ECL3 800-800 800 (7.0) 1 - 0
H8 831-834 - 0 831 (-4.9), 834 (-4.1) 2

Interactive visualizations

ΔRRCS distribution

Active vs inactive comparison

Residue-wise changes

TM domain breakdown

Variants of interest

304 variants mapped to contact positions, sorted by |ΔRRCS| impact.

Position Protein change DNA change Allele freq Het / Hom ΔRRCS AM score Pathogenicity Conservation dbSNP
172 p.Asn172Ser c.515A>G 1.40e-04 204 / 0 10.62 0.655 PATHOGENIC 0.97 rs376357186
148 p.Asn148Ser c.443A>G 6.84e-07 1 / 0 10.62 0.650 PATHOGENIC 1.00
172 p.Asn172Thr c.515A>C 1.37e-06 2 / 0 10.62 - nan - rs376357186
872 p.Ala872Pro c.2614G>C 6.84e-07 1 / 0 10.58 0.164 BENIGN 0.64 rs766857242
872 p.Ala872Val c.2615C>T 6.84e-07 1 / 0 10.58 - nan - rs370774159
196 p.Asn196Ser c.587A>G 3.42e-06 5 / 0 10.08 0.786 PATHOGENIC 0.99 rs1470496056
196 p.Asn196Ile c.587A>T 6.84e-07 1 / 0 10.08 - nan -
331 p.Glu331Gly c.992A>G 2.74e-06 4 / 0 9.51 0.411 AMBIGUOUS 0.67 rs373990636
308 p.His308Tyr c.922C>T 6.84e-07 1 / 0 9.51 0.143 BENIGN 0.57
308 p.His308Arg c.923A>G 6.84e-07 1 / 0 9.51 - nan - rs750014816
165 p.Arg165Cys c.493C>T 9.58e-05 140 / 0 8.76 0.376 AMBIGUOUS 0.70 rs148637417
165 p.Arg165His c.494G>A 9.58e-06 14 / 0 8.76 - nan - rs760177736
150 p.Ile150Phe c.448A>T 6.84e-07 1 / 0 8.63 0.445 AMBIGUOUS 0.79 rs1665548299
806 p.Glu806Gln c.2416G>C 6.84e-07 1 / 0 8.56 0.165 BENIGN 0.70 rs764891082
806 p.Glu806Lys c.2416G>A 1.30e-05 19 / 0 8.56 - nan - rs764891082
174 p.Leu174Phe c.520C>T 5.47e-06 8 / 0 8.49 0.411 AMBIGUOUS 0.94 rs371006987
627 p.Gly627Cys c.1879G>T 5.47e-06 8 / 0 8.39 0.564 AMBIGUOUS 0.91 rs1572033542
627 p.Gly627Asp c.1880G>A 1.37e-06 2 / 0 8.39 - nan - rs1156846916
552 p.Phe552Cys c.1655T>G 6.57e-06 1 / 0 8.25 0.874 PATHOGENIC 0.95 rs1410055494
720 p.Tyr720Asp c.2158T>G 6.84e-07 1 / 0 8.25 0.222 BENIGN 0.52
720 p.Tyr720Cys c.2159A>G 2.74e-06 4 / 0 8.25 - nan - rs944612520
774 p.His774Tyr c.2320C>T 9.58e-06 14 / 0 8.24 0.451 AMBIGUOUS 0.76 rs774413388
827 p.Tyr827Phe c.2480A>T 2.74e-06 4 / 0 8.24 0.186 BENIGN 0.98
774 p.His774Gln c.2322C>A 1.37e-06 2 / 0 8.24 - nan -
141 p.Gln141Lys c.421C>A 6.84e-07 1 / 0 8.05 0.226 BENIGN 0.66
744 p.Phe744Ser c.2231T>C 1.37e-06 2 / 0 7.89 0.742 PATHOGENIC 0.89 rs1252671536
786 p.Tyr786His c.2356T>C 2.05e-06 3 / 0 7.89 0.198 BENIGN 0.55 rs1572035289
744 p.Phe744Cys c.2231T>G 2.74e-06 4 / 0 7.89 - nan - rs1252671536
786 p.Tyr786Cys c.2357A>G 2.05e-06 3 / 0 7.89 - nan - rs758924475
557 p.Tyr557Asn c.1669T>A 1.37e-06 2 / 0 7.84 0.073 BENIGN 0.56
557 p.Tyr557Ser c.1670A>C 6.85e-07 1 / 0 7.84 - nan -
176 p.Glu176Gly c.527A>G 6.84e-06 10 / 0 7.83 0.137 BENIGN 0.72 rs1375379204
265 p.His265Asp c.793C>G 8.23e-06 12 / 0 7.82 0.660 PATHOGENIC 0.58 rs756762118
522 p.His522Tyr c.1564C>T 8.21e-06 12 / 0 7.82 0.077 BENIGN 0.55 rs760897338
265 p.His265Arg c.794A>G 2.74e-06 4 / 0 7.82 - nan -
265 p.His265Leu c.794A>T 6.86e-07 1 / 0 7.82 - nan -
522 p.His522Arg c.1565A>G 6.84e-07 1 / 0 7.82 - nan - rs1302643568
289 p.Tyr289Cys c.866A>G 6.84e-07 1 / 0 7.59 0.248 BENIGN 0.60 rs1471415364
146 p.Asp146Gly c.437A>G 3.42e-06 5 / 0 7.38 0.959 PATHOGENIC 0.77
194 p.Ala194Val c.581C>T 1.37e-06 2 / 0 7.38 0.928 PATHOGENIC 0.75 rs1457668577
404 p.Asp404Asn c.1210G>A 6.84e-07 1 / 0 7.37 0.362 AMBIGUOUS 0.53
382 p.Gln382Arg c.1145A>G 6.84e-07 1 / 0 7.37 0.122 BENIGN 0.52
404 p.Asp404Glu c.1212T>A 1.37e-06 2 / 0 7.37 - nan - rs1039616521
290 p.Asp290Tyr c.868G>T 2.05e-06 3 / 0 7.15 0.317 BENIGN 0.61 rs775614276
266 p.Asn266Tyr c.796A>T 6.86e-07 1 / 0 7.15 0.189 BENIGN 0.51
290 p.Asp290Gly c.869A>G 1.37e-06 2 / 0 7.15 - nan - rs762967039
501 p.His501Gln c.1503C>A 1.31e-05 2 / 0 7.03 0.096 BENIGN 0.46 rs142399954
500 p.Leu500Val c.1498C>G 6.84e-07 1 / 0 7.03 0.065 BENIGN 0.38
800 p.Leu800Pro c.2399T>C 6.84e-07 1 / 0 6.98 0.285 BENIGN 0.61
795 p.Ala795Thr c.2383G>A 3.42e-06 5 / 0 6.98 0.125 BENIGN 0.62 rs1255101634
151 p.Ser151Thr c.451T>A 2.87e-05 42 / 0 6.85 0.093 BENIGN 0.65 rs375518249
175 p.Thr175Ala c.523A>G 6.57e-06 1 / 0 6.85 0.077 BENIGN 0.73 rs1665558013
151 p.Ser151Phe c.452C>T 6.84e-07 1 / 0 6.85 - nan - rs867671554
175 p.Thr175Met c.524C>T 2.12e-05 31 / 0 6.85 - nan - rs760539969
144 p.Arg144Ser c.430C>A 4.79e-06 7 / 0 6.51 0.975 PATHOGENIC 0.72 rs775637496
144 p.Arg144Gly c.430C>G 6.85e-07 1 / 0 6.51 - nan - rs775637496
144 p.Arg144Cys c.430C>T 1.10e-05 16 / 0 6.51 - nan - rs775637496
144 p.Arg144His c.431G>A 6.85e-06 10 / 0 6.51 - nan - rs1271102676
144 p.Arg144Leu c.431G>T 6.85e-07 1 / 0 6.51 - nan -
555 p.Cys555Arg c.1663T>C 6.85e-07 1 / 0 6.49 0.942 PATHOGENIC 0.97
170 p.Asp170Val c.509A>T 1.37e-06 2 / 0 6.33 0.992 PATHOGENIC 0.73
675 p.Arg675Gly c.2023C>G 6.57e-06 1 / 0 6.15 0.114 BENIGN 0.46 rs141252120
757 p.Asp757Asn c.2269G>A 6.84e-07 1 / 0 6.15 0.094 BENIGN 0.45
675 p.Arg675Trp c.2023C>T 1.11e-05 16 / 0 6.15 - nan - rs141252120
675 p.Arg675Gln c.2024G>A 2.22e-05 32 / 0 6.15 - nan - rs767586087
675 p.Arg675Pro c.2024G>C 6.94e-07 1 / 0 6.15 - nan -
757 p.Asp757Glu c.2271C>A 6.57e-06 1 / 0 6.15 - nan - rs1253296862
517 p.Arg517Thr c.1550G>C 1.37e-06 2 / 0 5.87 0.087 BENIGN 0.38
518 p.Gln518Glu c.1552C>G 1.37e-06 2 / 0 5.87 0.067 BENIGN 0.45
562 p.Trp562Arg c.1684T>C 1.37e-06 2 / 0 5.84 0.817 PATHOGENIC 0.71
565 p.Arg565Cys c.1693C>T 8.21e-06 12 / 0 5.84 0.580 PATHOGENIC 0.99 rs748192170
565 p.Arg565Leu c.1694G>T 6.84e-07 1 / 0 5.84 - nan - rs771025632
565 p.Arg565His c.1694G>A 4.31e-05 63 / 0 5.84 - nan - rs771025632
122 p.Gln122Arg c.365A>G 6.84e-07 1 / 0 5.83 0.895 PATHOGENIC 0.66
120 p.Met120Val c.358A>G 1.37e-06 2 / 0 5.83 0.621 PATHOGENIC 0.54
120 p.Met120Leu c.358A>T 6.57e-06 1 / 0 5.83 - nan - rs1487885420
127 p.Gly127Arg c.379G>A 1.37e-06 2 / 0 5.82 0.067 BENIGN 0.41 rs1280951302
135 p.Trp135Gly c.403T>G 6.84e-07 1 / 0 5.81 0.065 BENIGN 0.40 rs1463095857
197 p.Arg197Cys c.589C>T 6.16e-06 9 / 0 5.75 0.083 BENIGN 0.53 rs866045411
197 p.Arg197Leu c.590G>T 1.37e-06 2 / 0 5.75 - nan - rs142083498
197 p.Arg197His c.590G>A 1.78e-05 26 / 0 5.75 - nan - rs142083498
96 p.Arg96Cys c.286C>T 7.53e-06 11 / 0 5.74 0.774 PATHOGENIC 0.66 rs949643125
96 p.Arg96Ser c.286C>A 1.37e-06 2 / 0 5.74 - nan -
96 p.Arg96His c.287G>A 8.90e-06 13 / 0 5.74 - nan - rs202048176
192 p.Thr192Ala c.574A>G 6.84e-07 1 / 0 5.63 0.846 PATHOGENIC 0.69
192 p.Thr192Ile c.575C>T 3.42e-06 5 / 0 5.63 - nan -
242 p.Asn242Ser c.725A>G 4.11e-06 6 / 0 5.59 0.189 BENIGN 0.68 rs747780687
221 p.Arg221Cys c.661C>T 1.09e-05 16 / 0 5.59 0.097 BENIGN 0.62 rs754157620
221 p.Arg221Leu c.662G>T 6.57e-06 1 / 0 5.59 - nan - rs372287043
221 p.Arg221His c.662G>A 1.78e-05 26 / 0 5.59 - nan - rs372287043
173 p.Ala173Val c.518C>T 6.84e-07 1 / 0 5.57 0.088 BENIGN 0.49 rs1191214344
171 p.Asp171Asn c.511G>A 3.42e-06 5 / 0 5.56 0.600 PATHOGENIC 0.70 rs1352975816
171 p.Asp171Glu c.513C>G 8.21e-06 12 / 0 5.56 - nan - rs201941100
303 p.Tyr303Cys c.908A>G 6.57e-06 1 / 0 5.49 0.123 BENIGN 0.42 rs1340286770
325 p.Lys325Gln c.973A>C 1.99e-05 29 / 0 5.49 0.106 BENIGN 0.46
325 p.Lys325Arg c.974A>G 6.84e-07 1 / 0 5.49 - nan -
220 p.Asn220His c.658A>C 4.79e-06 7 / 0 5.43 0.947 PATHOGENIC 0.86 rs766622084
220 p.Asn220Lys c.660C>A 1.37e-06 2 / 0 5.43 - nan -
44 p.Asp44Asn c.130G>A 1.42e-06 2 / 0 5.38 0.131 BENIGN 0.69 rs762854585
42 p.Gln42Lys c.124C>A 7.13e-07 1 / 0 5.38 0.091 BENIGN 0.47
42 p.Gln42Pro c.125A>C 1.07e-05 15 / 0 5.38 - nan - rs770874974
42 p.Gln42His c.126G>T 1.42e-06 2 / 0 5.38 - nan - rs775426943
44 p.Asp44Gly c.131A>G 4.27e-06 6 / 0 5.38 - nan - rs1161742084
502 p.Leu502Phe c.1504C>T 1.37e-06 2 / 0 5.33 0.083 BENIGN 0.41
502 p.Leu502Pro c.1505T>C 2.26e-05 33 / 0 5.33 - nan - rs149311642
355 p.Arg355Gly c.1063C>G 1.37e-06 2 / 0 5.32 0.193 BENIGN 0.52 rs1052089261
355 p.Arg355Gln c.1064G>A 3.98e-05 58 / 0 5.32 - nan - rs561614256
355 p.Arg355Leu c.1064G>T 6.87e-07 1 / 0 5.32 - nan -
163 p.Ser163Cys c.488C>G 6.84e-07 1 / 0 5.32 0.069 BENIGN 0.56 rs747408179
164 p.Leu164Phe c.490C>T 4.10e-06 6 / 0 5.24 0.909 PATHOGENIC 0.99 rs376744380
823 p.Asn823Lys c.2469C>A 6.84e-07 1 / 0 5.16 0.968 PATHOGENIC 1.00
778 p.Leu778Pro c.2333T>C 3.42e-06 5 / 0 5.16 0.935 PATHOGENIC 1.00 rs760517633
809 p.Lys809Glu c.2425A>G 6.84e-07 1 / 0 5.12 0.738 PATHOGENIC 0.95 rs1654378387
337 p.Arg337Ser c.1009C>A 3.43e-06 5 / 0 5.12 0.289 BENIGN 0.45 rs762462851
337 p.Arg337Cys c.1009C>T 3.91e-05 57 / 0 5.12 - nan - rs762462851
337 p.Arg337His c.1010G>A 4.64e-04 674 / 1 5.12 - nan - rs111928234
337 p.Arg337Leu c.1010G>T 1.37e-06 2 / 0 5.12 - nan - rs111928234
287 p.His287Arg c.860A>G 4.31e-05 63 / 0 5.00 0.271 BENIGN 0.58 rs760867154
287 p.His287Leu c.860A>T 6.57e-06 1 / 0 5.00 - nan - rs760867154
287 p.His287Gln c.861C>A 6.84e-07 1 / 0 5.00 - nan -
469 p.Arg469Ser c.1407G>T 6.84e-07 1 / 0 4.88 0.534 AMBIGUOUS 0.71
541 p.Pro541Thr c.1621C>A 6.84e-07 1 / 0 4.88 0.078 BENIGN 0.50
469 p.Arg469Ser c.1407G>C 1.37e-06 2 / 0 4.88 - nan - rs141213868
541 p.Pro541Leu c.1622C>T 1.31e-05 2 / 0 4.88 - nan - rs1260923333
541 p.Pro541Arg c.1622C>G 6.84e-07 1 / 0 4.88 - nan - rs1260923333
187 p.Ala187Val c.560C>T 6.84e-07 1 / 0 4.87 0.096 BENIGN 0.54
195 p.Leu195Arg c.584T>G 6.84e-07 1 / 0 4.87 0.624 PATHOGENIC 0.69 rs1279111734
703 p.Leu703Pro c.2108T>C 1.37e-06 2 / 0 4.83 0.485 AMBIGUOUS 0.82
708 p.Val708Glu c.2123T>A 6.86e-07 1 / 0 4.83 0.367 AMBIGUOUS 0.62
311 p.Ser311Ala c.931T>G 6.85e-07 1 / 0 4.81 0.178 BENIGN 0.49
311 p.Ser311Thr c.931T>A 1.37e-06 2 / 0 4.81 - nan -
88 p.His88Tyr c.262C>T 2.05e-06 3 / 0 4.79 0.112 BENIGN 0.47 rs772933524
88 p.His88Pro c.263A>C 4.10e-06 6 / 0 4.79 - nan - rs760295025
88 p.His88Gln c.264C>G 1.37e-06 2 / 0 4.79 - nan - rs1660473333
559 p.Phe559Leu c.1677T>G 1.51e-05 22 / 0 4.79 0.715 PATHOGENIC 0.64 rs749467740
392 p.Asp392Asn c.1174G>A 1.37e-06 2 / 0 4.71 0.083 BENIGN 0.55 rs138466949
56 p.Gly56Arg c.166G>A 1.19e-05 17 / 0 4.69 0.530 AMBIGUOUS 0.76 rs572587382
77 p.Asn77Lys c.231C>A 6.84e-07 1 / 0 4.69 0.473 AMBIGUOUS 0.85 rs373184201
56 p.Gly56Arg c.166G>C 7.03e-07 1 / 0 4.69 - nan - rs572587382
56 p.Gly56Glu c.167G>A 3.52e-06 5 / 0 4.69 - nan - rs553857540
264 p.Phe264Leu c.790T>C 6.58e-06 1 / 0 4.67 0.933 PATHOGENIC 0.78 rs1049267213
288 p.Phe288Leu c.864T>G 1.37e-06 2 / 0 4.67 0.803 PATHOGENIC 0.64 rs771101043
509 p.Lys509Glu c.1525A>G 1.37e-06 2 / 0 4.65 0.106 BENIGN 0.55
509 p.Lys509Asn c.1527A>C 6.84e-07 1 / 0 4.65 - nan - rs1436249569
274 p.Glu274Lys c.820G>A 2.05e-06 3 / 0 4.60 0.207 BENIGN 0.69
274 p.Glu274Gly c.821A>G 6.85e-07 1 / 0 4.60 - nan -
20 p.Arg20Trp c.58C>T 2.26e-05 28 / 0 4.59 0.117 BENIGN 0.33 rs1163318852
19 p.Arg19Trp c.55C>T 2.06e-06 3 / 0 4.59 0.106 BENIGN 0.47 rs764875066
20 p.Arg20Gln c.59G>A 1.62e-06 2 / 0 4.59 - nan - rs1256347480
20 p.Arg20Pro c.59G>C 8.09e-07 1 / 0 4.59 - nan -
20 p.Arg20Leu c.59G>T 1.46e-05 18 / 0 4.59 - nan - rs1256347480
19 p.Arg19Gly c.55C>G 1.37e-06 2 / 0 4.59 - nan -
19 p.Arg19Leu c.56G>T 6.85e-06 10 / 0 4.59 - nan - rs575178889
19 p.Arg19Gln c.56G>A 4.80e-06 7 / 0 4.59 - nan - rs575178889
19 p.Arg19Pro c.56G>C 6.85e-07 1 / 0 4.59 - nan - rs575178889
19 p.Ala19Thr c.55G>A 7.19e-07 1 / 0 4.59 - nan -
19 p.Ala19Ser c.55G>T 2.24e-04 309 / 1 4.59 - nan - rs78418110
19 p.Ala19Val c.56C>T 3.60e-06 5 / 0 4.59 - nan - rs772005735
19 p.Ala19Asp c.56C>A 1.44e-06 2 / 0 4.59 - nan - rs772005735
19 p.Ala19Gly c.56C>G 7.19e-07 1 / 0 4.59 - nan -
776 p.Ala776Ser c.2326G>T 6.84e-07 1 / 0 4.59 0.157 BENIGN 0.96
751 p.Tyr751Cys c.2252A>G 6.84e-07 1 / 0 4.59 0.147 BENIGN 0.94
776 p.Ala776Thr c.2326G>A 6.84e-07 1 / 0 4.59 - nan - rs1391177707
551 p.Pro551Ser c.1651C>T 6.88e-07 1 / 0 4.49 0.231 BENIGN 0.70 rs1417751019
551 p.Pro551His c.1652C>A 6.88e-07 1 / 0 4.49 - nan - rs756414761
551 p.Pro551Leu c.1652C>T 2.06e-06 3 / 0 4.49 - nan - rs756414761
385 p.Arg385Cys c.1153C>T 1.53e-04 223 / 0 4.41 0.142 BENIGN 0.49 rs150875603
385 p.Arg385His c.1154G>A 3.15e-05 46 / 0 4.41 - nan - rs527790135
385 p.Arg385Leu c.1154G>T 2.05e-06 3 / 0 4.41 - nan - rs527790135
302 p.Gln302Arg c.905A>G 6.84e-07 1 / 0 4.29 0.078 BENIGN 0.61 rs1272714714
302 p.Gln302His c.906G>C 6.84e-07 1 / 0 4.29 - nan -
240 p.Asp240Asn c.718G>A 1.37e-06 2 / 0 4.28 0.733 PATHOGENIC 0.74
240 p.Asp240Ala c.719A>C 2.74e-06 4 / 0 4.28 - nan - rs2148245152
297 p.Gly297Ala c.890G>C 6.84e-07 1 / 0 4.25 0.386 AMBIGUOUS 0.66
297 p.Gly297Glu c.890G>A 6.57e-06 1 / 0 4.25 - nan - rs1326942576
494 p.Gln494His c.1482G>T 6.84e-07 1 / 0 4.19 0.125 BENIGN 0.55 rs781032583
496 p.Glu496Lys c.1486G>A 6.84e-07 1 / 0 4.19 0.080 BENIGN 0.54 rs1457925301
741 p.Ser741Pro c.2221T>C 1.37e-06 2 / 0 4.15 0.631 PATHOGENIC 0.50 rs1313093505
741 p.Ser741Phe c.2222C>T 6.57e-06 1 / 0 4.15 - nan - rs1654351337
243 p.Tyr243Cys c.728A>G 6.84e-07 1 / 0 4.13 0.099 BENIGN 0.58
834 p.Phe834Ser c.2501T>C 9.58e-06 14 / 0 4.12 0.259 BENIGN 0.85 rs1405802041
133 p.Ala133Val c.398C>T 6.84e-07 1 / 0 4.03 0.202 BENIGN 0.73 rs1291463656
107 p.Gly107Ala c.320G>C 6.84e-07 1 / 0 4.03 0.091 BENIGN 0.45
313 p.Asn313Asp c.937A>G 8.21e-06 12 / 0 4.00 0.324 BENIGN 0.53 rs371568966
313 p.Asn313Ser c.938A>G 6.84e-07 1 / 0 4.00 - nan -
723 p.Pro723Ser c.2167C>T 6.84e-07 1 / 0 3.98 0.083 BENIGN 0.51 rs748597333
726 p.Gln726Lys c.2176C>A 6.84e-07 1 / 0 3.98 0.077 BENIGN 0.38
726 p.Gln726Arg c.2177A>G 2.05e-06 3 / 0 3.98 - nan - rs772314448
169 p.Leu169Met c.505C>A 6.84e-07 1 / 0 3.98 0.322 BENIGN 0.96
740 p.Asn740Ile c.2219A>T 6.84e-07 1 / 0 3.96 0.709 PATHOGENIC 0.88
363 p.Gln363Glu c.1087C>G 1.37e-06 2 / 0 3.94 0.077 BENIGN 0.42 rs571335333
729 p.Ala729Thr c.2185G>A 4.11e-06 6 / 0 3.93 0.080 BENIGN 0.53 rs1166021003
254 p.Arg254Trp c.760C>T 1.30e-05 19 / 0 3.93 0.113 BENIGN 0.60 rs765602623
254 p.Arg254Gln c.761G>A 1.40e-04 204 / 0 3.93 - nan - rs143648261
218 p.His218Arg c.653A>G 2.74e-06 4 / 0 3.91 0.754 PATHOGENIC 0.64
198 p.Ile198Thr c.593T>C 1.37e-06 2 / 0 3.90 0.935 PATHOGENIC 0.84 rs1490457860
157 p.Ser157Gly c.469A>G 6.84e-07 1 / 0 3.87 0.138 BENIGN 0.62
129 p.Ile129Val c.385A>G 6.84e-07 1 / 0 3.87 0.101 BENIGN 0.67
129 p.Ile129Thr c.386T>C 6.84e-07 1 / 0 3.87 - nan - rs980899902
129 p.Ile129Met c.387C>G 1.57e-05 23 / 0 3.87 - nan - rs745508830
157 p.Ser157Arg c.471C>G 3.42e-06 5 / 0 3.87 - nan - rs1029770577
132 p.Glu132Lys c.394G>A 6.84e-07 1 / 0 3.80 0.088 BENIGN 0.58
132 p.Glu132Asp c.396G>C 1.57e-05 23 / 0 3.80 - nan -
125 p.Gln125His c.375G>C 1.37e-06 2 / 0 3.80 0.145 BENIGN 0.66 rs761890258
101 p.His101Tyr c.301C>T 6.84e-07 1 / 0 3.80 0.090 BENIGN 0.48
101 p.His101Pro c.302A>C 6.57e-06 1 / 0 3.80 - nan - rs1224929850
101 p.His101Arg c.302A>G 3.42e-06 5 / 0 3.80 - nan - rs1224929850
101 p.His101Gln c.303T>A 6.84e-07 1 / 0 3.80 - nan - rs148320351
208 p.Asn208Asp c.622A>G 6.84e-07 1 / 0 3.78 0.264 BENIGN 0.67 rs762550634
183 p.Asn183His c.547A>C 6.84e-06 10 / 0 3.78 0.071 BENIGN 0.47 rs757783383
208 p.Asn208His c.622A>C 6.84e-07 1 / 0 3.78 - nan -
208 p.Asn208Thr c.623A>C 6.84e-07 1 / 0 3.78 - nan - rs1374802627
138 p.Pro138Arg c.413C>G 2.05e-06 3 / 0 3.78 0.089 BENIGN 0.47 rs749850205
138 p.Pro138Gln c.413C>A 3.28e-05 48 / 0 3.78 - nan - rs749850205
138 p.Pro138Leu c.413C>T 4.11e-06 6 / 0 3.78 - nan - rs749850205
299 p.Ser299Leu c.896C>T 3.42e-06 5 / 0 3.73 0.155 BENIGN 0.63 rs761470187
299 p.Ser299Trp c.896C>G 1.37e-06 2 / 0 3.73 - nan - rs761470187
362 p.Asn362Asp c.1084A>G 2.74e-06 4 / 0 3.72 0.926 PATHOGENIC 0.81 rs759748423
362 p.Asn362Thr c.1085A>C 1.37e-06 2 / 0 3.72 - nan - rs551458925
362 p.Asn362Ser c.1085A>G 1.78e-05 26 / 0 3.72 - nan - rs551458925
350 p.Gln350Leu c.1049A>T 1.03e-05 15 / 0 3.71 0.134 BENIGN 0.50 rs769340367
329 p.Ser329Gly c.985A>G 7.53e-06 9 / 1 3.69 0.099 BENIGN 0.63 rs533343519
353 p.Arg353Gly c.1057A>G 6.86e-07 1 / 0 3.69 0.074 BENIGN 0.42
329 p.Ser329Asn c.986G>A 6.84e-07 1 / 0 3.69 - nan - rs1386847288
181 p.Ala181Ser c.541G>T 6.84e-07 1 / 0 3.69 0.144 BENIGN 0.68 rs764787317
155 p.Glu155Lys c.463G>A 2.05e-06 3 / 0 3.69 0.089 BENIGN 0.54 rs760319959
155 p.Glu155Gly c.464A>G 3.42e-06 5 / 0 3.69 - nan - rs753439617
181 p.Ala181Asp c.542C>A 1.37e-06 2 / 0 3.69 - nan - rs917085995
294 p.Gln294Leu c.881A>T 1.37e-06 2 / 0 3.68 0.145 BENIGN 0.51 rs1391715701
372 p.Arg372Met c.1115G>T 6.84e-07 1 / 0 3.65 0.167 BENIGN 0.44
349 p.Gln349Arg c.1046A>G 6.85e-07 1 / 0 3.65 0.077 BENIGN 0.50
372 p.Arg372Thr c.1115G>C 4.79e-06 7 / 0 3.65 - nan -
372 p.Arg372Lys c.1115G>A 6.84e-07 1 / 0 3.65 - nan -
286 p.Ile286Val c.856A>G 6.57e-06 1 / 0 3.65 0.109 BENIGN 0.77 rs370716767
286 p.Ile286Thr c.857T>C 1.37e-06 2 / 0 3.65 - nan - rs1558074911
269 p.Ile269Val c.805A>G 1.37e-06 2 / 0 3.57 0.345 AMBIGUOUS 0.81 rs1334115812
248 p.Glu248Gly c.743A>G 6.16e-06 9 / 0 3.57 0.127 BENIGN 0.62 rs746452395
269 p.Ile269Met c.807C>G 6.85e-07 1 / 0 3.57 - nan -
190 p.Ala190Thr c.568G>A 6.84e-07 1 / 0 3.56 0.739 PATHOGENIC 0.73 rs951279931
142 p.Ser142Ala c.424T>G 6.84e-07 1 / 0 3.56 0.481 AMBIGUOUS 0.73
142 p.Ser142Leu c.425C>T 2.05e-06 3 / 0 3.56 - nan - rs748544384
190 p.Ala190Gly c.569C>G 6.84e-07 1 / 0 3.56 - nan - rs1665563036
523 p.Tyr523His c.1567T>C 6.59e-06 1 / 0 3.55 0.123 BENIGN 0.57 rs1365964654
523 p.Tyr523Phe c.1568A>T 6.84e-07 1 / 0 3.55 - nan - rs776892212
917 p.Cys917Ser c.2749T>A 2.74e-06 4 / 0 3.53 0.085 BENIGN 0.48 rs200800067
916 p.His916Arg c.2747A>G 8.89e-06 13 / 0 3.53 0.071 BENIGN 0.77 rs56400751
917 p.Cys917Tyr c.2750G>A 2.74e-06 4 / 0 3.53 - nan - rs753682169
276 p.Ala276Thr c.826G>A 6.85e-07 1 / 0 3.53 0.347 AMBIGUOUS 0.75
276 p.Ala276Gly c.827C>G 6.85e-07 1 / 0 3.53 - nan - rs2148260251
276 p.Ala276Val c.827C>T 6.85e-07 1 / 0 3.53 - nan -
358 p.Glu358Lys c.1072G>A 2.05e-06 3 / 0 3.53 0.630 PATHOGENIC 0.56 rs760985628
733 p.Thr733Ile c.2198C>T 1.37e-06 2 / 0 3.52 0.175 BENIGN 0.50
797 p.Met797Val c.2389A>G 6.84e-07 1 / 0 3.52 0.063 BENIGN 0.50 rs1211607467
755 p.Tyr755Asp c.2263T>G 2.74e-06 4 / 0 3.51 0.522 AMBIGUOUS 0.92
772 p.Val772Met c.2314G>A 2.74e-06 4 / 0 3.51 0.221 BENIGN 0.60 rs866747971
309 p.Thr309Ile c.926C>T 2.05e-06 3 / 0 3.51 0.251 BENIGN 0.52
102 p.Leu102Phe c.304C>T 4.11e-06 6 / 0 3.47 0.355 AMBIGUOUS 0.82 rs1264040049
412 p.Ser412Phe c.1235C>T 6.84e-07 1 / 0 3.44 0.092 BENIGN 0.42 rs1458992912
87 p.His87Tyr c.259C>T 6.84e-07 1 / 0 3.42 0.086 BENIGN 0.44 rs1660472410
87 p.His87Gln c.261C>G 6.84e-07 1 / 0 3.42 - nan - rs1416725601
87 p.His87Gln c.261C>A 6.84e-07 1 / 0 3.42 - nan -
204 p.Tyr204Asp c.610T>G 5.34e-05 78 / 0 3.40 0.093 BENIGN 0.44 rs376700653
231 p.Glu231Lys c.691G>A 1.23e-05 18 / 0 3.40 0.091 BENIGN 0.52 rs546447981
204 p.Tyr204Asn c.610T>A 1.03e-05 15 / 0 3.40 - nan - rs376700653
204 p.Tyr204Ser c.611A>C 6.57e-06 1 / 0 3.40 - nan - rs1665568438
204 p.Tyr204Cys c.611A>G 2.05e-06 3 / 0 3.40 - nan - rs1665568438
231 p.Glu231Gln c.691G>C 2.74e-06 4 / 0 3.40 - nan - rs546447981
231 p.Glu231Asp c.693G>C 2.05e-06 3 / 0 3.40 - nan - rs144135845
193 p.Leu193Pro c.578T>C 1.37e-06 2 / 0 3.37 0.992 PATHOGENIC 0.95
423 p.Ser423Phe c.1268C>T 6.84e-07 1 / 0 3.36 0.173 BENIGN 0.55
285 p.Thr285Met c.854C>T 4.80e-06 7 / 0 3.30 0.110 BENIGN 0.59 rs866514672
285 p.Thr285Lys c.854C>A 6.86e-07 1 / 0 3.30 - nan -
310 p.Leu310Val c.928C>G 6.84e-07 1 / 0 3.30 0.261 BENIGN 0.87
538 p.Lys538Arg c.1613A>G 4.99e-05 73 / 0 3.28 0.074 BENIGN 0.57 rs548446631
139 p.Ser139Gly c.415A>G 6.84e-07 1 / 0 3.28 0.064 BENIGN 0.58
139 p.Ser139Arg c.417C>G 2.05e-06 3 / 0 3.28 - nan - rs913900036
894 p.Tyr894Phe c.2681A>T 1.37e-06 2 / 0 3.27 0.133 BENIGN 0.69 rs1458078730
894 p.Tyr894Cys c.2681A>G 4.11e-06 6 / 0 3.27 - nan -
99 p.Gly99Arg c.295G>A 6.84e-07 1 / 0 3.27 0.936 PATHOGENIC 0.72
123 p.Asn123Tyr c.367A>T 4.10e-06 6 / 0 3.27 0.793 PATHOGENIC 0.72
99 p.Gly99Ala c.296G>C 6.58e-06 1 / 0 3.27 - nan - rs763246637
99 p.Gly99Glu c.296G>A 2.05e-06 3 / 0 3.27 - nan - rs763246637
123 p.Asn123Lys c.369C>A 6.84e-07 1 / 0 3.27 - nan -
716 p.Leu716Val c.2146C>G 6.85e-07 1 / 0 3.26 0.177 BENIGN 0.72
323 p.Asp323Asn c.967G>A 6.84e-07 1 / 0 3.24 0.096 BENIGN 0.61
323 p.Asp323Tyr c.967G>T 1.57e-05 23 / 0 3.24 - nan - rs757554050
121 p.Leu121Met c.361C>A 6.84e-06 10 / 0 3.24 0.557 AMBIGUOUS 0.93
158 p.Phe158Ser c.473T>C 6.84e-07 1 / 0 3.24 0.952 PATHOGENIC 0.92
185 p.Leu185Val c.553C>G 2.05e-06 3 / 0 3.24 0.200 BENIGN 0.84 rs751966123
185 p.Leu185Pro c.554T>C 1.37e-06 2 / 0 3.24 - nan -
710 p.Glu710Lys c.2128G>A 6.85e-07 1 / 0 3.21 0.110 BENIGN 0.59
710 p.Glu710Gly c.2129A>G 6.85e-07 1 / 0 3.21 - nan - rs1327053372
710 p.Glu710Ala c.2129A>C 6.85e-07 1 / 0 3.21 - nan - rs1327053372
805 p.Pro805Ser c.2413C>T 6.84e-07 1 / 0 3.18 0.125 BENIGN 0.59
805 p.Pro805Ala c.2413C>G 7.53e-06 11 / 0 3.18 - nan - rs201706873
805 p.Pro805Thr c.2413C>A 6.84e-07 1 / 0 3.18 - nan - rs201706873
177 p.Ile177Val c.529A>G 6.57e-06 1 / 0 3.12 0.088 BENIGN 0.70 rs1301067417
314 p.Gly314Asp c.941G>A 6.84e-07 1 / 0 3.08 0.664 PATHOGENIC 0.64 rs758843676
178 p.Pro178Leu c.533C>T 6.84e-07 1 / 0 3.03 0.680 PATHOGENIC 0.81 rs2148163019
459 p.Ala459Val c.1376C>T 6.84e-07 1 / 0 3.01 0.101 BENIGN 0.46
631 p.Glu631Lys c.1891G>A 6.85e-07 1 / 0 3.01 0.070 BENIGN 0.50
200 p.His200Asn c.598C>A 2.05e-06 3 / 0 3.00 0.084 BENIGN 0.58
224 p.His224Arg c.671A>G 3.42e-06 5 / 0 3.00 0.066 BENIGN 0.45 rs779140957
200 p.His200Gln c.600C>A 6.84e-07 1 / 0 3.00 - nan -

Complete RRCS results

Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.34, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.

Res1 AA1 Res2 AA2 Active RRCS Inactive RRCS ΔRRCS |ΔRRCS|
148 ASN 172 ASN 0.000 10.623 -10.623 10.623
767 TRP 872 ALA 10.584 0.000 10.584 10.584
172 ASN 196 ASN 0.000 10.082 -10.082 10.082
308 HIS 331 GLU 16.118 6.604 9.514 9.514
165 ARG 189 GLN 0.000 8.763 -8.763 8.763
150 ILE 172 ASN 0.000 8.626 -8.626 8.626
560 GLU 806 GLU 8.557 0.000 8.557 8.557
174 LEU 196 ASN 0.000 8.491 -8.491 8.491
556 GLU 627 GLY 0.000 8.388 -8.388 8.388
552 PHE 720 TYR 0.000 8.247 -8.247 8.247
774 HIS 827 TYR 0.000 8.243 -8.243 8.243
141 GLN 165 ARG 0.000 8.053 -8.053 8.053
744 PHE 786 TYR 0.813 8.705 -7.893 7.893
556 GLU 557 TYR 0.000 7.842 -7.842 7.842
153 VAL 176 GLU 7.833 0.000 7.833 7.833
265 HIS 522 HIS 7.820 0.000 7.820 7.820
265 HIS 289 TYR 12.059 19.649 -7.590 7.590
146 ASP 194 ALA 7.381 0.000 7.381 7.381
382 GLN 404 ASP 2.437 9.810 -7.373 7.373
266 ASN 290 ASP 3.315 10.467 -7.152 7.152
500 LEU 501 HIS 8.287 1.259 7.027 7.027
795 ALA 800 LEU 8.113 1.131 6.982 6.982
151 SER 175 THR 6.846 0.000 6.846 6.846
892 GLU 893 THR 0.592 7.272 -6.680 6.680
144 ARG 168 TRP 0.000 6.514 -6.514 6.514
555 CYS 630 SER 0.017 6.502 -6.486 6.486
935 GLU 936 LEU 0.429 6.779 -6.349 6.349
146 ASP 170 ASP 0.000 6.330 -6.330 6.330
675 ARG 757 ASP 2.819 8.970 -6.152 6.152
284 GLN 306 LYS 3.090 9.093 -6.004 6.004
150 ILE 196 ASN 5.927 0.000 5.927 5.927
517 ARG 518 GLN 0.072 5.945 -5.873 5.873
562 TRP 565 ARG 0.464 6.302 -5.838 5.838
120 MET 122 GLN 0.000 5.832 -5.832 5.832
127 GLY 175 THR 5.820 0.000 5.820 5.820
135 TRP 159 GLU 0.000 5.809 -5.809 5.809
174 LEU 197 ARG 0.000 5.751 -5.751 5.751
72 ASP 96 ARG 4.600 10.339 -5.740 5.740
170 ASP 192 THR 0.000 5.631 -5.631 5.631
242 ASN 265 HIS 11.982 17.569 -5.588 5.588
197 ARG 221 ARG 0.000 5.586 -5.586 5.586
150 ILE 173 ALA 0.000 5.571 -5.571 5.571
147 ALA 171 ASP 0.000 5.557 -5.557 5.557
303 TYR 325 LYS 2.450 7.936 -5.485 5.485
220 ASN 244 ASN 3.349 8.779 -5.430 5.430
170 ASP 194 ALA 0.000 5.384 -5.384 5.384
42 GLN 44 ASP 5.378 0.000 5.378 5.378
502 LEU 503 ASP 0.000 5.332 -5.332 5.332
331 GLU 355 ARG 12.349 7.025 5.324 5.324
140 LEU 163 SER 0.000 5.320 -5.320 5.320
165 ARG 188 LEU 0.000 5.291 -5.291 5.291
143 LEU 168 TRP 0.000 5.274 -5.274 5.274
140 LEU 164 LEU 0.000 5.239 -5.239 5.239
778 LEU 823 ASN 0.000 5.164 -5.164 5.164
560 GLU 809 LYS 0.236 5.357 -5.120 5.120
315 ALA 337 ARG 5.575 0.455 5.120 5.120
287 HIS 289 TYR 6.291 1.293 4.999 4.999
827 TYR 831 ASN 0.000 4.912 -4.912 4.912
469 ARG 541 PRO 0.000 4.878 -4.878 4.878
140 LEU 187 ALA 4.869 0.000 4.869 4.869
126 LEU 149 LEU 1.026 5.893 -4.867 4.867
147 ALA 195 LEU 4.865 0.000 4.865 4.865
703 LEU 708 VAL 3.711 8.537 -4.826 4.826
289 TYR 311 SER 4.814 0.000 4.814 4.814
565 ARG 626 PHE 8.580 3.785 4.795 4.795
88 HIS 89 LEU 4.791 0.000 4.791 4.791
559 PHE 565 ARG 6.252 1.467 4.785 4.785
774 HIS 778 LEU 0.000 4.727 -4.727 4.727
369 SER 392 ASP 3.076 7.785 -4.709 4.709
56 GLY 77 ASN 0.426 5.111 -4.686 4.686
264 PHE 288 PHE 9.156 4.486 4.670 4.670
508 SER 509 LYS 0.000 4.655 -4.655 4.655
304 LEU 327 THR 4.231 8.865 -4.634 4.634
274 GLU 298 ARG 1.203 5.800 -4.597 4.597
19 SER 20 ARG 0.000 4.588 -4.588 4.588
751 TYR 776 ALA 0.000 4.588 -4.588 4.588
150 ILE 197 ARG 4.588 0.000 4.588 4.588
141 GLN 189 GLN 4.575 0.000 4.575 4.575
145 LEU 168 TRP 0.000 4.497 -4.497 4.497
164 LEU 188 LEU 0.000 4.486 -4.486 4.486
551 PRO 806 GLU 0.000 4.485 -4.485 4.485
149 LEU 197 ARG 4.483 0.000 4.483 4.483
774 HIS 826 LEU 0.000 4.473 -4.473 4.473
551 PRO 809 LYS 0.000 4.471 -4.471 4.471
151 SER 176 GLU 4.464 0.000 4.464 4.464
365 GLU 385 ARG 2.851 7.265 -4.414 4.414
146 ASP 168 TRP 0.000 4.397 -4.397 4.397
140 LEU 188 LEU 4.386 0.000 4.386 4.386
557 TYR 626 PHE 1.322 5.696 -4.374 4.374
156 ARG 159 GLU 0.000 4.337 -4.337 4.337
141 GLN 164 LEU 0.000 4.314 -4.314 4.314
355 ARG 377 GLU 10.465 14.778 -4.313 4.313
302 GLN 303 TYR 8.326 4.036 4.291 4.291
240 ASP 242 ASN 3.072 7.356 -4.284 4.284
274 GLU 297 GLY 2.027 6.278 -4.251 4.251
494 GLN 496 GLU 4.189 0.000 4.189 4.189
741 SER 786 TYR 9.468 5.318 4.150 4.150
243 TYR 266 ASN 5.988 10.122 -4.134 4.134
828 LEU 834 PHE 0.220 4.343 -4.123 4.123
164 LEU 187 ALA 0.000 4.083 -4.083 4.083
141 GLN 166 HIS 0.000 4.081 -4.081 4.081
107 GLY 133 ALA 0.743 4.768 -4.026 4.026
288 PHE 313 ASN 3.998 0.000 3.998 3.998
216 HIS 240 ASP 5.739 1.749 3.990 3.990
723 PRO 726 GLN 3.984 0.000 3.984 3.984
169 LEU 192 THR 0.000 3.982 -3.982 3.982
740 ASN 786 TYR 8.078 4.116 3.962 3.962
363 GLN 385 ARG 0.000 3.945 -3.945 3.945
708 VAL 729 ALA 3.926 0.000 3.926 3.926
254 ARG 275 LYS 3.925 0.000 3.925 3.925
218 HIS 219 ASN 0.000 3.910 -3.910 3.910
198 ILE 221 ARG 2.001 5.902 -3.900 3.900
135 TRP 156 ARG 0.000 3.873 -3.873 3.873
129 ILE 157 SER 0.000 3.868 -3.868 3.868
173 ALA 197 ARG 0.000 3.843 -3.843 3.843
166 HIS 168 TRP 0.000 3.830 -3.830 3.830
556 GLU 629 PHE 0.381 4.197 -3.816 3.816
107 GLY 132 GLU 2.237 6.035 -3.798 3.798
101 HIS 125 GLN 0.248 4.043 -3.796 3.796
127 GLY 149 LEU 0.266 4.058 -3.792 3.792
558 LEU 809 LYS 6.588 2.805 3.783 3.783
183 ASN 208 ASN 9.731 5.948 3.783 3.783
138 PRO 163 SER 0.000 3.777 -3.777 3.777
274 GLU 299 SER 3.970 7.702 -3.732 3.732
340 ILE 362 ASN 1.668 5.388 -3.719 3.719
324 LEU 350 GLN 1.409 5.124 -3.715 3.715
407 TRP 431 ASP 12.948 9.242 3.707 3.707
329 SER 353 ARG 0.698 4.392 -3.694 3.694
155 GLU 181 ALA 0.000 3.693 -3.693 3.693
294 GLN 315 ALA 0.000 3.685 -3.685 3.685
175 THR 198 ILE 0.000 3.676 -3.676 3.676
264 PHE 289 TYR 3.671 0.000 3.671 3.671
150 ILE 174 LEU 0.000 3.665 -3.665 3.665
265 HIS 266 ASN 0.000 3.663 -3.663 3.663
171 ASP 195 LEU 0.000 3.657 -3.657 3.657
349 GLN 372 ARG 5.524 1.877 3.647 3.647
286 ILE 311 SER 3.646 0.000 3.646 3.646
194 ALA 218 HIS 3.768 7.408 -3.641 3.641
243 TYR 265 HIS 2.324 5.948 -3.623 3.623
284 GLN 308 HIS 4.805 1.203 3.602 3.602
248 GLU 269 ILE 0.400 3.966 -3.566 3.566
142 SER 190 ALA 3.562 0.000 3.562 3.562
243 TYR 523 TYR 3.547 0.000 3.547 3.547
165 ARG 190 ALA 0.000 3.545 -3.545 3.545
916 HIS 917 CYS 0.000 3.533 -3.533 3.533
254 ARG 276 ALA 3.527 0.000 3.527 3.527
145 LEU 192 THR 3.526 0.000 3.526 3.526
358 GLU 360 SER 0.428 3.954 -3.526 3.526
733 THR 797 MET 3.524 0.000 3.524 3.524
755 TYR 772 VAL 3.512 0.000 3.512 3.512
286 ILE 309 THR 3.509 0.000 3.509 3.509
126 LEU 150 ILE 0.074 3.580 -3.506 3.506
144 ARG 192 THR 3.476 0.000 3.476 3.476
102 LEU 124 ASN 3.756 7.228 -3.472 3.472
168 TRP 192 THR 0.000 3.471 -3.471 3.471
388 GLU 412 SER 3.720 7.162 -3.441 3.441
141 GLN 188 LEU 3.426 0.000 3.426 3.426
87 HIS 111 SER 2.085 5.503 -3.418 3.418
204 TYR 231 GLU 5.952 2.548 3.405 3.405
148 ASN 196 ASN 3.388 0.000 3.388 3.388
265 HIS 287 HIS 0.686 4.072 -3.386 3.386
145 LEU 193 LEU 3.366 0.000 3.366 3.366
141 GLN 190 ALA 3.361 0.000 3.361 3.361
400 LEU 423 SER 7.775 4.417 3.358 3.358
122 GLN 144 ARG 4.890 8.241 -3.351 3.351
143 LEU 192 THR 3.318 0.000 3.318 3.318
285 THR 309 THR 3.298 0.000 3.298 3.298
286 ILE 310 LEU 3.296 0.000 3.296 3.296
535 GLU 538 LYS 3.283 0.000 3.283 3.283
139 SER 163 SER 0.000 3.275 -3.275 3.275
108 GLN 132 GLU 3.275 0.000 3.275 3.275
893 THR 894 TYR 0.000 3.270 -3.270 3.270
99 GLY 123 ASN 3.644 6.912 -3.268 3.268
218 HIS 240 ASP 3.789 7.054 -3.265 3.265
716 LEU 809 LYS 3.522 0.261 3.261 3.261
302 GLN 323 ASP 3.534 6.778 -3.244 3.244
121 LEU 146 ASP 3.238 0.000 3.238 3.238
158 PHE 185 LEU 0.000 3.236 -3.236 3.236
287 HIS 311 SER 3.226 0.000 3.226 3.226
193 LEU 218 HIS 3.218 0.000 3.218 3.218
216 HIS 218 HIS 5.087 1.873 3.214 3.214
710 GLU 726 GLN 0.000 3.208 -3.208 3.208
145 LEU 194 ALA 3.192 0.000 3.192 3.192
552 PHE 805 PRO 0.000 3.176 -3.176 3.176
142 SER 168 TRP 0.000 3.154 -3.154 3.154
284 GLN 309 THR 3.239 0.095 3.144 3.144
151 SER 177 ILE 3.119 0.000 3.119 3.119
291 ASN 314 GLY 3.082 0.000 3.082 3.082
143 LEU 166 HIS 0.000 3.075 -3.075 3.075
153 VAL 178 PRO 0.155 3.189 -3.035 3.035
459 ALA 631 GLU 3.011 0.000 3.011 3.011
150 ILE 177 ILE 3.004 0.000 3.004 3.004
805 PRO 806 GLU 0.000 3.001 -3.001 3.001
200 HIS 224 HIS 7.013 4.012 3.001 3.001
148 ASN 171 ASP 0.000 2.993 -2.993 2.993
555 CYS 629 PHE 0.000 2.980 -2.980 2.980
143 LEU 190 ALA 2.972 0.000 2.972 2.972
334 THR 358 GLU 7.034 4.076 2.958 2.958
242 ASN 263 GLY 2.749 5.692 -2.943 2.943
386 ILE 408 ASN 5.152 8.090 -2.938 2.938
325 LYS 350 GLN 1.096 4.021 -2.924 2.924
97 LEU 122 GLN 2.923 0.000 2.923 2.923
313 ASN 336 THR 9.477 6.561 2.916 2.916
131 ALA 157 SER 0.000 2.907 -2.907 2.907
97 LEU 121 LEU 4.014 1.137 2.877 2.877
167 LEU 191 MET 0.000 2.867 -2.867 2.867
428 ASP 449 LYS 6.849 9.708 -2.858 2.858
143 LEU 167 LEU 0.000 2.848 -2.848 2.848
246 LEU 267 ASN 5.081 7.911 -2.830 2.830
721 ALA 730 LEU 0.000 2.811 -2.811 2.811
521 ASN 522 HIS 0.277 3.087 -2.811 2.811
653 SER 654 GLU 0.526 3.335 -2.810 2.810
288 PHE 312 LEU 4.268 1.459 2.809 2.809
265 HIS 288 PHE 0.000 2.808 -2.808 2.808
143 LEU 191 MET 2.796 0.000 2.796 2.796
141 GLN 163 SER 0.000 2.780 -2.780 2.780
507 SER 508 SER 0.649 3.429 -2.780 2.780
127 GLY 150 ILE 0.303 3.063 -2.760 2.760
127 GLY 151 SER 0.000 2.757 -2.757 2.757
166 HIS 190 ALA 0.000 2.757 -2.757 2.757
64 LEU 88 HIS 2.753 0.000 2.753 2.753
594 LEU 599 PHE 2.828 0.088 2.741 2.741
744 PHE 782 ASP 2.618 5.346 -2.728 2.728
175 THR 197 ARG 0.000 2.721 -2.721 2.721
142 SER 166 HIS 0.000 2.719 -2.719 2.719
121 LEU 145 LEU 3.848 1.148 2.700 2.700
751 TYR 775 VAL 1.118 3.807 -2.688 2.688
747 VAL 779 ILE 0.000 2.685 -2.685 2.685
477 TYR 633 GLY 0.981 3.661 -2.680 2.680
338 ALA 362 ASN 9.880 7.213 2.667 2.667
359 LEU 381 LEU 3.436 0.771 2.665 2.665
169 LEU 196 ASN 0.000 2.658 -2.658 2.658
98 SER 122 GLN 5.528 8.185 -2.657 2.657
74 SER 98 SER 7.173 9.829 -2.656 2.656
780 PHE 784 LEU 5.501 2.848 2.653 2.653
179 VAL 205 ALA 2.640 5.289 -2.648 2.648
829 LEU 835 ARG 2.643 0.000 2.643 2.643
131 ALA 181 ALA 2.624 0.000 2.624 2.624
193 LEU 217 LEU 3.397 0.783 2.614 2.614
369 SER 371 HIS 1.091 3.701 -2.609 2.609
254 ARG 278 MET 2.606 0.000 2.606 2.606
556 GLU 628 GLN 0.000 2.600 -2.600 2.600
229 SER 230 PHE 1.542 4.132 -2.590 2.590
704 PRO 709 GLY 7.450 4.881 2.569 2.569
771 MET 873 PHE 2.558 0.000 2.558 2.558
597 VAL 666 GLN 0.000 2.539 -2.539 2.539
186 PRO 208 ASN 0.000 2.534 -2.534 2.534
174 LEU 198 ILE 0.000 2.533 -2.533 2.533
145 LEU 172 ASN 0.000 2.532 -2.532 2.532
269 ILE 291 ASN 4.846 7.373 -2.527 2.527
177 ILE 206 PHE 0.000 2.519 -2.519 2.519
782 ASP 819 PRO 0.000 2.519 -2.519 2.519
151 SER 173 ALA 0.000 2.509 -2.509 2.509
145 LEU 196 ASN 2.508 0.000 2.508 2.508
167 LEU 192 THR 0.000 2.495 -2.495 2.495
141 GLN 187 ALA 2.492 0.000 2.492 2.492
919 GLU 920 PRO 3.100 0.608 2.491 2.491
272 ILE 288 PHE 2.872 0.407 2.465 2.465
552 PHE 801 PHE 2.453 0.000 2.453 2.453
167 LEU 190 ALA 0.000 2.447 -2.447 2.447
636 TRP 715 PRO 2.638 5.080 -2.442 2.442
673 CYS 679 LYS 2.283 4.724 -2.441 2.441
718 LEU 720 TYR 2.435 0.000 2.435 2.435
290 ASP 313 ASN 2.427 0.000 2.427 2.427
475 TYR 634 ALA 2.146 4.561 -2.414 2.414
551 PRO 560 GLU 0.000 2.414 -2.414 2.414
614 SER 645 THR 4.144 1.744 2.400 2.400
154 PRO 157 SER 0.000 2.393 -2.393 2.393
399 SER 423 SER 2.878 0.489 2.389 2.389
38 PRO 55 LEU 5.465 3.076 2.389 2.389
16 LEU 17 CYS 0.000 2.382 -2.382 2.382
364 ILE 384 ASN 5.615 7.996 -2.381 2.381
944 THR 945 PRO 3.953 1.586 2.367 2.367
376 LEU 399 SER 7.161 4.795 2.366 2.366
318 ILE 339 GLY 6.700 4.361 2.339 2.339
554 PRO 629 PHE 0.000 2.322 -2.322 2.322
957 GLN 959 SER 0.000 2.322 -2.322 2.322
144 ARG 146 ASP 7.307 9.626 -2.319 2.319
78 LEU 102 LEU 6.296 3.982 2.315 2.315
755 TYR 763 PHE 0.000 2.302 -2.302 2.302
759 PRO 762 ASP 0.000 2.279 -2.279 2.279
597 VAL 771 MET 0.000 2.276 -2.276 2.276
831 ASN 834 PHE 2.690 0.416 2.274 2.274
552 PHE 809 LYS 0.000 2.266 -2.266 2.266
489 PHE 806 GLU 0.000 2.259 -2.259 2.259
501 HIS 502 LEU 0.000 2.257 -2.257 2.257
152 LEU 177 ILE 2.253 0.000 2.253 2.253
74 SER 96 ARG 0.443 2.685 -2.242 2.242
315 ALA 338 ALA 4.532 2.298 2.235 2.235
878 LEU 879 ILE 0.000 2.230 -2.230 2.230
896 PHE 897 PRO 0.351 2.578 -2.227 2.227
434 LEU 453 ASN 5.203 7.426 -2.222 2.222
595 PRO 598 LYS 3.372 1.150 2.222 2.222
250 PRO 264 PHE 2.211 0.000 2.211 2.211
375 LYS 399 SER 3.309 1.113 2.197 2.197
920 PRO 921 GLU 2.548 0.355 2.193 2.193
660 LEU 782 ASP 0.000 2.189 -2.189 2.189
79 THR 103 SER 2.852 0.665 2.187 2.187
240 ASP 263 GLY 3.590 1.408 2.182 2.182
361 HIS 383 HIS 13.427 11.248 2.179 2.179
785 LEU 819 PRO 3.581 1.407 2.174 2.174
204 TYR 207 GLN 1.633 3.803 -2.170 2.170
335 LEU 360 SER 2.374 0.205 2.169 2.169
927 ASN 928 PRO 2.178 0.012 2.166 2.166
811 VAL 816 LEU 0.187 2.348 -2.161 2.161
668 SER 750 ALA 2.391 4.551 -2.160 2.160
484 MET 543 VAL 0.000 2.150 -2.150 2.150
195 LEU 219 ASN 6.622 4.472 2.149 2.149
158 PHE 181 ALA 0.000 2.145 -2.145 2.145
134 LEU 161 LEU 0.000 2.143 -2.143 2.143
708 VAL 728 ALA 2.140 0.000 2.140 2.140
734 VAL 797 MET 3.747 1.618 2.129 2.129
719 PRO 733 THR 1.406 3.519 -2.113 2.113
737 VAL 794 PHE 2.662 0.550 2.112 2.112
199 SER 221 ARG 1.323 3.434 -2.111 2.111
337 ARG 361 HIS 4.747 6.857 -2.110 2.110
128 GLY 150 ILE 0.000 2.109 -2.109 2.109
758 LEU 771 MET 2.108 0.000 2.108 2.108
943 SER 944 THR 3.101 1.016 2.085 2.085
80 GLU 82 GLN 0.000 2.075 -2.075 2.075
837 ASP 840 ARG 0.236 2.310 -2.074 2.074
336 THR 358 GLU 0.143 2.216 -2.072 2.072
217 LEU 242 ASN 2.070 0.000 2.070 2.070
835 ARG 839 ARG 2.070 0.000 2.070 2.070
111 SER 136 GLU 0.000 2.066 -2.066 2.066
187 ALA 211 SER 0.642 2.701 -2.059 2.059
477 TYR 629 PHE 0.744 2.794 -2.050 2.050
121 LEU 148 ASN 4.305 2.274 2.032 2.032
144 ARG 520 GLU 2.030 0.000 2.030 2.030
128 GLY 176 GLU 2.028 0.000 2.028 2.028
291 ASN 313 ASN 2.027 0.000 2.027 2.027
147 ALA 194 ALA 2.026 0.000 2.026 2.026
129 ILE 153 VAL 0.000 2.025 -2.025 2.025
751 TYR 779 ILE 0.793 2.814 -2.021 2.021
42 GLN 48 LEU 1.213 3.229 -2.016 2.016
879 ILE 880 LEU 0.000 2.016 -2.016 2.016
888 PRO 889 PRO 0.504 2.510 -2.006 2.006
328 THR 350 GLN 0.189 2.186 -1.997 1.997
316 MET 337 ARG 3.240 1.248 1.992 1.992
711 TYR 719 PRO 2.527 0.535 1.992 1.992
293 ILE 314 GLY 3.070 1.082 1.988 1.988
335 LEU 359 LEU 5.028 3.043 1.985 1.985
506 GLU 507 SER 0.000 1.985 -1.985 1.985
217 LEU 241 LEU 2.928 0.945 1.983 1.983
758 LEU 766 VAL 0.000 1.979 -1.979 1.979
917 CYS 918 VAL 0.000 1.974 -1.974 1.974
891 LEU 892 GLU 0.241 2.210 -1.969 1.969
129 ILE 177 ILE 1.962 0.000 1.962 1.962
674 VAL 679 LYS 1.420 3.374 -1.954 1.954
167 LEU 169 LEU 0.000 1.952 -1.952 1.952
283 LEU 307 LEU 4.439 2.494 1.945 1.945
138 PRO 187 ALA 1.944 0.000 1.944 1.944
582 VAL 828 LEU 2.190 0.255 1.935 1.935
628 GLN 631 GLU 2.625 4.555 -1.930 1.930
80 GLU 104 HIS 1.907 0.000 1.907 1.907
301 PHE 310 LEU 2.193 4.092 -1.899 1.899
219 ASN 243 TYR 5.559 7.452 -1.893 1.893
242 ASN 264 PHE 2.054 3.946 -1.892 1.892
557 TYR 627 GLY 2.092 3.962 -1.870 1.870
77 ASN 101 HIS 2.403 0.537 1.866 1.866
557 TYR 809 LYS 1.918 0.056 1.863 1.863
596 PRO 666 GLN 0.599 2.459 -1.860 1.860
962 ALA 963 PHE 0.000 1.853 -1.853 1.853
269 ILE 292 PRO 3.788 5.637 -1.849 1.849
631 GLU 632 TYR 0.876 2.719 -1.842 1.842
751 TYR 772 VAL 0.000 1.842 -1.842 1.842
672 SER 753 LYS 1.062 2.904 -1.841 1.841
183 ASN 206 PHE 1.839 0.000 1.839 1.839
586 VAL 587 PHE 0.000 1.833 -1.833 1.833
241 LEU 263 GLY 2.944 4.775 -1.831 1.831
122 GLN 146 ASP 7.508 9.340 -1.831 1.831
638 THR 643 ARG 0.257 2.079 -1.822 1.822
774 HIS 870 LEU 1.816 0.000 1.816 1.816
574 LEU 825 LEU 0.105 1.914 -1.809 1.809
307 LEU 330 LEU 6.131 4.324 1.807 1.807
604 ILE 827 TYR 1.804 0.000 1.804 1.804
311 SER 313 ASN 0.000 1.791 -1.791 1.791
114 TYR 138 PRO 1.784 0.000 1.784 1.784
204 TYR 228 HIS 4.859 6.642 -1.783 1.783
448 LEU 465 PHE 0.896 2.676 -1.779 1.779
436 THR 458 GLN 2.282 0.505 1.777 1.777
53 SER 74 SER 6.215 4.445 1.770 1.770
147 ALA 170 ASP 0.000 1.769 -1.769 1.769
737 VAL 786 TYR 2.588 4.355 -1.768 1.768
35 CYS 41 CYS 4.344 6.109 -1.764 1.764
484 MET 545 CYS 2.118 0.354 1.763 1.763
79 THR 102 LEU 4.256 2.493 1.763 1.763
183 ASN 207 GLN 2.255 0.493 1.762 1.762
275 LYS 278 MET 1.694 3.451 -1.757 1.757
47 MET 67 LEU 0.000 1.756 -1.756 1.756
601 VAL 834 PHE 1.755 0.000 1.755 1.755
301 PHE 327 THR 1.054 2.808 -1.754 1.754
203 ASP 228 HIS 8.660 10.412 -1.752 1.752
165 ARG 166 HIS 0.121 1.871 -1.750 1.750
477 TYR 634 ALA 0.701 2.450 -1.749 1.749
915 SER 916 HIS 3.823 2.074 1.749 1.749
238 THR 261 GLU 6.741 4.993 1.749 1.749
391 ALA 417 ALA 3.178 1.435 1.744 1.744
939 ARG 940 ALA 0.000 1.737 -1.737 1.737
81 LEU 106 PRO 4.122 2.395 1.728 1.728
462 LYS 482 TYR 1.131 2.851 -1.720 1.720
552 PHE 715 PRO 1.212 2.931 -1.719 1.719
135 TRP 184 ASN 1.718 0.000 1.718 1.718
103 SER 125 GLN 1.765 3.481 -1.717 1.717
303 TYR 327 THR 0.000 1.712 -1.712 1.712
73 LEU 96 ARG 3.129 4.837 -1.708 1.708
900 THR 901 LEU 0.000 1.708 -1.708 1.708
660 LEU 779 ILE 0.000 1.696 -1.696 1.696
35 CYS 40 HIS 0.000 1.687 -1.687 1.687
551 PRO 805 PRO 3.726 2.045 1.681 1.681
660 LEU 823 ASN 1.676 0.000 1.676 1.676
519 ALA 520 GLU 0.000 1.673 -1.673 1.673
173 ALA 196 ASN 0.000 1.669 -1.669 1.669
193 LEU 220 ASN 4.515 2.851 1.665 1.665
96 ARG 120 MET 3.482 5.136 -1.653 1.653
129 ILE 176 GLU 1.652 0.000 1.652 1.652
127 GLY 174 LEU 1.651 0.000 1.651 1.651
17 CYS 18 ALA 0.000 1.647 -1.647 1.647
268 ASN 292 PRO 1.702 3.347 -1.645 1.645
409 ALA 433 GLN 0.253 1.898 -1.645 1.645
316 MET 339 GLY 2.444 0.800 1.643 1.643
674 VAL 880 LEU 1.643 0.000 1.643 1.643
171 ASP 194 ALA 0.000 1.640 -1.640 1.640
293 ILE 315 ALA 4.139 2.503 1.636 1.636
33 THR 65 ASP 0.000 1.631 -1.631 1.631
601 VAL 827 TYR 3.587 1.959 1.628 1.628
83 PRO 106 PRO 2.621 0.996 1.625 1.625
484 MET 548 THR 2.002 0.378 1.624 1.624
965 SER 966 HIS 0.187 1.802 -1.615 1.615
348 CYS 372 ARG 3.290 4.899 -1.609 1.609
289 TYR 313 ASN 1.607 0.000 1.607 1.607
302 GLN 325 LYS 4.335 2.734 1.601 1.601
46 ILE 67 LEU 0.000 1.598 -1.598 1.598
129 ILE 158 PHE 0.000 1.592 -1.592 1.592
105 ILE 126 LEU 2.192 0.606 1.587 1.587
20 ARG 21 ARG 0.000 1.583 -1.583 1.583
958 PRO 959 SER 0.000 1.582 -1.582 1.582
146 ASP 172 ASN 0.000 1.582 -1.582 1.582
758 LEU 767 TRP 0.000 1.581 -1.581 1.581
384 ASN 408 ASN 7.834 9.415 -1.580 1.580
585 THR 838 LEU 1.910 0.333 1.577 1.577
176 GLU 198 ILE 0.000 1.577 -1.577 1.577
149 LEU 172 ASN 0.000 1.572 -1.572 1.572
262 LEU 286 ILE 1.795 3.363 -1.568 1.568
875 ASP 876 VAL 0.000 1.566 -1.566 1.566
321 PHE 344 PRO 4.872 3.307 1.564 1.564
164 LEU 185 LEU 0.000 1.562 -1.562 1.562
177 ILE 198 ILE 0.000 1.561 -1.561 1.561
657 VAL 740 ASN 1.991 3.547 -1.557 1.557
101 HIS 124 ASN 0.000 1.551 -1.551 1.551
281 PRO 306 LYS 1.549 0.000 1.549 1.549
552 PHE 808 VAL 0.000 1.546 -1.546 1.546
211 SER 235 ASN 0.194 1.739 -1.545 1.545
168 TRP 170 ASP 0.000 1.536 -1.536 1.536
48 LEU 68 THR 3.796 5.332 -1.536 1.536
371 HIS 396 GLN 1.553 0.018 1.535 1.535
53 SER 72 ASP 1.147 2.682 -1.535 1.535
480 CYS 555 CYS 7.232 5.698 1.533 1.533
719 PRO 732 PHE 0.428 1.955 -1.527 1.527
131 ALA 178 PRO 1.526 0.000 1.526 1.526
253 ILE 280 ASN 4.520 6.045 -1.525 1.525
747 VAL 751 TYR 1.524 0.000 1.524 1.524
143 LEU 188 LEU 1.522 0.000 1.522 1.522
3 SER 4 PRO 0.593 2.112 -1.519 1.519
118 ILE 142 SER 2.654 4.172 -1.518 1.518
241 LEU 264 PHE 2.573 1.055 1.517 1.517
150 ILE 198 ILE 1.517 0.000 1.517 1.517
299 SER 302 GLN 1.019 2.533 -1.513 1.513
818 LEU 822 LEU 0.134 1.643 -1.509 1.509
288 PHE 311 SER 4.541 3.037 1.503 1.503
199 SER 222 ILE 2.379 3.879 -1.500 1.500
906 GLN 907 PRO 1.991 0.495 1.496 1.496
559 PHE 809 LYS 0.104 1.597 -1.493 1.493
336 THR 360 SER 6.116 4.624 1.492 1.492
185 LEU 209 LEU 0.884 2.376 -1.492 1.492
145 LEU 150 ILE 0.148 1.638 -1.490 1.490
333 LEU 335 LEU 1.486 0.000 1.486 1.486
170 ASP 196 ASN 0.000 1.485 -1.485 1.485
732 PHE 736 LEU 3.914 2.430 1.485 1.485
469 ARG 540 HIS 0.000 1.483 -1.483 1.483
748 ALA 779 ILE 1.477 0.000 1.477 1.477
165 ARG 187 ALA 0.000 1.471 -1.471 1.471
200 HIS 202 PRO 0.048 1.517 -1.469 1.469
887 ARG 888 PRO 0.926 2.390 -1.464 1.464
924 HIS 925 PHE 0.000 1.462 -1.462 1.462
338 ALA 340 ILE 1.456 0.000 1.456 1.456
249 PHE 273 PRO 3.162 4.618 -1.455 1.455
321 PHE 347 MET 1.693 3.143 -1.450 1.450
235 ASN 258 ARG 4.021 5.459 -1.438 1.438
21 ARG 22 ALA 0.000 1.437 -1.437 1.437
267 ASN 291 ASN 9.167 10.604 -1.437 1.437
617 LEU 645 THR 1.370 2.803 -1.433 1.433
582 VAL 827 TYR 0.000 1.433 -1.433 1.433
711 TYR 717 CYS 7.543 6.111 1.432 1.432
658 LEU 696 LEU 0.538 1.968 -1.430 1.430
477 TYR 554 PRO 1.009 2.435 -1.426 1.426
41 CYS 48 LEU 0.039 1.464 -1.425 1.425
167 LEU 188 LEU 0.000 1.417 -1.417 1.417
321 PHE 340 ILE 0.295 1.710 -1.415 1.415
125 GLN 148 ASN 0.000 1.413 -1.413 1.413
559 PHE 813 LEU 4.066 2.655 1.412 1.412
356 VAL 378 GLU 3.812 2.400 1.412 1.412
294 GLN 316 MET 0.000 1.408 -1.408 1.408
137 LEU 161 LEU 0.000 1.408 -1.408 1.408
770 ALA 832 PRO 0.000 1.403 -1.403 1.403
505 GLU 506 GLU 0.000 1.402 -1.402 1.402
477 TYR 630 SER 2.616 4.016 -1.400 1.400
307 LEU 329 SER 4.829 3.433 1.396 1.396
302 GLN 327 THR 0.000 1.392 -1.392 1.392
102 LEU 126 LEU 5.335 3.944 1.391 1.391
579 ASN 608 ASN 4.823 6.210 -1.387 1.387
275 LYS 299 SER 4.441 5.819 -1.378 1.378
654 GLU 736 LEU 1.150 2.527 -1.376 1.376
90 ARG 112 GLY 0.000 1.376 -1.376 1.376
331 GLU 353 ARG 3.812 2.439 1.373 1.373
153 VAL 179 VAL 1.373 0.000 1.373 1.373
704 PRO 711 TYR 6.504 5.132 1.372 1.372
442 LEU 445 LEU 0.000 1.370 -1.370 1.370
385 ARG 408 ASN 0.839 2.209 -1.370 1.370
175 THR 199 SER 0.000 1.369 -1.369 1.369
245 LYS 267 ASN 1.044 2.407 -1.363 1.363
313 ASN 334 THR 0.000 1.361 -1.361 1.361
714 SER 716 LEU 0.289 1.649 -1.361 1.361
98 SER 120 MET 0.000 1.360 -1.360 1.360
636 TRP 642 CYS 8.136 9.495 -1.358 1.358
87 HIS 112 GLY 0.193 1.549 -1.356 1.356
153 VAL 177 ILE 1.356 0.000 1.356 1.356
293 ILE 316 MET 1.354 0.000 1.354 1.354
358 GLU 382 GLN 2.945 4.298 -1.354 1.354
212 LEU 235 ASN 3.736 5.089 -1.353 1.353
558 LEU 629 PHE 2.231 3.584 -1.353 1.353
157 SER 158 PHE 1.892 0.541 1.351 1.351
83 PRO 108 GLN 0.537 1.885 -1.348 1.348
451 LYS 472 GLU 1.859 3.205 -1.345 1.345
479 CYS 549 PRO 0.076 1.421 -1.345 1.345
321 PHE 343 LEU 0.000 1.341 -1.341 1.341
155 GLU 184 ASN 0.000 1.332 -1.332 1.332
117 LYS 141 GLN 4.942 6.271 -1.330 1.330
75 MET 99 GLY 2.866 4.194 -1.328 1.328
123 ASN 147 ALA 3.861 5.188 -1.327 1.327
39 CYS 51 ASP 2.242 3.564 -1.322 1.322
69 ALA 92 LEU 3.883 5.205 -1.322 1.322
554 PRO 560 GLU 0.000 1.317 -1.317 1.317
305 PRO 328 THR 1.552 0.236 1.315 1.315
348 CYS 370 LEU 2.058 3.370 -1.313 1.313
169 LEU 193 LEU 0.000 1.312 -1.312 1.312
461 SER 482 TYR 0.871 2.182 -1.311 1.311
411 ARG 433 GLN 5.898 7.207 -1.309 1.309
421 LEU 441 GLY 1.692 0.388 1.305 1.305
435 THR 456 LEU 1.586 2.888 -1.302 1.302
143 LEU 164 LEU 0.000 1.301 -1.301 1.301
153 VAL 154 PRO 1.491 0.192 1.299 1.299
713 ALA 721 ALA 1.297 0.000 1.297 1.297
142 SER 188 LEU 1.297 0.000 1.297 1.297
134 LEU 143 LEU 0.000 1.294 -1.294 1.294
339 GLY 363 GLN 0.660 1.954 -1.294 1.294
284 GLN 307 LEU 4.457 3.163 1.294 1.294
218 HIS 244 ASN 0.018 1.309 -1.291 1.291
254 ARG 279 GLY 1.163 2.451 -1.288 1.288
751 TYR 778 LEU 1.282 0.000 1.282 1.282
337 ARG 362 ASN 1.699 0.419 1.280 1.280
456 LEU 475 TYR 1.801 0.521 1.279 1.279
146 ASP 192 THR 1.279 0.000 1.279 1.279
195 LEU 218 HIS 1.605 2.884 -1.279 1.279
151 SER 174 LEU 0.000 1.276 -1.276 1.276
387 TRP 388 GLU 3.013 4.286 -1.273 1.273
434 LEU 455 ALA 3.903 2.630 1.273 1.273
124 ASN 148 ASN 9.152 10.417 -1.265 1.265
744 PHE 779 ILE 1.262 0.000 1.262 1.262
366 GLU 387 TRP 0.135 1.396 -1.261 1.261
125 GLN 149 LEU 0.000 1.260 -1.260 1.260
50 ALA 70 TYR 4.306 5.565 -1.259 1.259
114 TYR 136 GLU 1.257 0.000 1.257 1.257
262 LEU 285 THR 3.505 2.249 1.256 1.256
166 HIS 188 LEU 0.000 1.253 -1.253 1.253
288 PHE 301 PHE 0.000 1.253 -1.253 1.253
335 LEU 340 ILE 0.759 2.012 -1.253 1.253
503 ASP 504 ASP 0.000 1.251 -1.251 1.251
646 GLY 711 TYR 7.611 8.859 -1.249 1.249
777 TRP 780 PHE 0.000 1.243 -1.243 1.243
579 ASN 824 PRO 5.487 6.729 -1.242 1.242
426 LYS 529 GLU 1.241 0.000 1.241 1.241
767 TRP 773 ARG 0.000 1.241 -1.241 1.241
142 SER 164 LEU 0.000 1.241 -1.241 1.241
660 LEU 778 LEU 0.000 1.238 -1.238 1.238
323 ASP 350 GLN 1.509 2.747 -1.237 1.237
249 PHE 276 ALA 3.306 4.540 -1.234 1.234
32 PRO 33 THR 0.000 1.229 -1.229 1.229
559 PHE 564 ILE 0.523 1.750 -1.228 1.228
584 LEU 841 LEU 0.946 2.174 -1.228 1.228
194 ALA 220 ASN 2.953 1.726 1.227 1.227
249 PHE 253 ILE 0.087 1.310 -1.222 1.222
306 LYS 329 SER 1.765 0.545 1.220 1.220
194 ALA 216 HIS 0.000 1.220 -1.220 1.220
579 ASN 605 ALA 5.903 7.122 -1.219 1.219
270 LYS 294 GLN 4.637 3.419 1.219 1.219
800 LEU 801 PHE 0.000 1.218 -1.218 1.218
117 LYS 139 SER 2.633 1.417 1.216 1.216
553 LYS 713 ALA 0.745 1.960 -1.216 1.216
301 PHE 312 LEU 1.815 0.601 1.214 1.214
485 CYS 549 PRO 0.000 1.211 -1.211 1.211
434 LEU 456 LEU 3.722 2.512 1.210 1.210
108 GLN 111 SER 1.221 0.014 1.207 1.207
158 PHE 167 LEU 0.000 1.206 -1.206 1.206
552 PHE 716 LEU 0.000 1.205 -1.205 1.205
192 THR 216 HIS 5.237 4.035 1.202 1.202
343 LEU 364 ILE 2.003 0.801 1.202 1.202
84 GLY 108 GLN 1.813 3.014 -1.201 1.201
795 ALA 802 PRO 1.193 0.000 1.193 1.193
628 GLN 632 TYR 1.404 0.213 1.190 1.190
437 LEU 458 GLN 1.190 0.000 1.190 1.190
105 ILE 130 PRO 2.707 1.519 1.188 1.188
360 SER 361 HIS 2.533 1.347 1.186 1.186
154 PRO 181 ALA 0.000 1.182 -1.182 1.182
704 PRO 732 PHE 2.677 3.852 -1.175 1.175
363 GLN 384 ASN 0.488 1.662 -1.174 1.174
387 TRP 409 ALA 2.235 3.406 -1.171 1.171
574 LEU 821 CYS 1.774 2.943 -1.169 1.169
720 TYR 722 PRO 0.000 1.167 -1.167 1.167
354 LEU 375 LYS 3.397 4.563 -1.166 1.166
62 GLY 88 HIS 1.164 0.000 1.164 1.164
216 HIS 521 ASN 1.157 0.000 1.157 1.157
277 PHE 283 LEU 0.191 1.347 -1.157 1.157
608 ASN 820 ALA 6.656 7.813 -1.156 1.156
212 LEU 236 LEU 4.347 5.503 -1.156 1.156
358 GLU 380 GLY 3.683 4.835 -1.152 1.152
137 LEU 185 LEU 1.150 0.000 1.150 1.150
103 SER 127 GLY 1.522 0.375 1.147 1.147
206 PHE 231 GLU 1.726 0.583 1.143 1.143
186 PRO 211 SER 2.832 3.974 -1.142 1.142
231 GLU 255 THR 0.241 1.381 -1.139 1.139
418 PHE 438 PRO 1.841 0.703 1.138 1.138
177 ILE 201 ILE 0.000 1.137 -1.137 1.137
520 GLU 521 ASN 0.051 1.187 -1.136 1.136
195 LEU 220 ASN 1.693 0.559 1.135 1.135
292 PRO 314 GLY 1.134 0.000 1.134 1.134
578 CYS 828 LEU 0.786 1.920 -1.134 1.134
371 HIS 372 ARG 5.977 7.110 -1.133 1.133
608 ASN 823 ASN 2.384 1.252 1.131 1.131
755 TYR 771 MET 1.130 0.000 1.130 1.130
151 SER 197 ARG 1.129 0.000 1.129 1.129
129 ILE 178 PRO 1.129 0.000 1.129 1.129
251 VAL 254 ARG 1.122 0.000 1.122 1.122
394 PHE 403 LEU 1.538 2.658 -1.120 1.120
938 LEU 939 ARG 2.031 3.150 -1.118 1.118
386 ILE 409 ALA 4.309 5.427 -1.118 1.118
396 GLN 420 THR 2.188 3.306 -1.117 1.117
27 GLN 28 PRO 0.481 1.597 -1.115 1.115
152 LEU 198 ILE 1.114 0.000 1.114 1.114
321 PHE 335 LEU 1.113 0.000 1.113 1.113
961 LEU 962 ALA 0.000 1.112 -1.112 1.112
552 PHE 714 SER 0.094 1.201 -1.107 1.107
189 GLN 212 LEU 3.990 5.094 -1.104 1.104
206 PHE 215 LEU 0.374 1.477 -1.103 1.103
247 GLN 270 LYS 1.694 0.592 1.102 1.102
124 ASN 126 LEU 1.346 0.245 1.101 1.101
287 HIS 309 THR 1.101 0.000 1.101 1.101
786 TYR 790 ALA 2.783 1.684 1.099 1.099
418 PHE 442 LEU 1.607 2.705 -1.098 1.098
571 ILE 818 LEU 0.067 1.162 -1.095 1.095
560 GLU 810 SER 1.093 0.000 1.093 1.093
305 PRO 326 GLY 2.244 3.337 -1.093 1.093
145 LEU 169 LEU 0.000 1.093 -1.093 1.093
458 GLN 478 GLN 2.869 3.961 -1.092 1.092
158 PHE 161 LEU 0.000 1.091 -1.091 1.091
515 LEU 516 ALA 0.000 1.090 -1.090 1.090
13 CYS 14 ALA 0.000 1.090 -1.090 1.090
792 LEU 803 VAL 0.405 1.494 -1.089 1.089
272 ILE 295 PHE 4.463 3.375 1.089 1.089
218 HIS 242 ASN 5.626 4.537 1.089 1.089
588 ALA 841 LEU 1.911 0.825 1.085 1.085
126 LEU 148 ASN 5.367 6.450 -1.083 1.083
476 ALA 547 PRO 3.876 4.956 -1.080 1.080
479 CYS 484 MET 1.453 0.377 1.076 1.076
327 THR 351 LEU 1.727 0.654 1.074 1.074
320 GLU 340 ILE 0.076 1.148 -1.072 1.072
191 MET 206 PHE 0.226 1.293 -1.067 1.067
449 LYS 472 GLU 8.406 7.346 1.060 1.060
277 PHE 286 ILE 1.538 2.597 -1.059 1.059
561 SER 564 ILE 2.866 1.808 1.058 1.058
264 PHE 287 HIS 4.639 3.581 1.058 1.058
763 PHE 767 TRP 0.000 1.053 -1.053 1.053
162 SER 187 ALA 0.000 1.053 -1.053 1.053
637 GLU 715 PRO 2.444 3.492 -1.048 1.048
34 ALA 65 ASP 0.000 1.044 -1.044 1.044
618 LEU 716 LEU 1.695 2.733 -1.038 1.038
510 ARG 511 PRO 0.307 1.343 -1.036 1.036
105 ILE 121 LEU 0.513 1.549 -1.036 1.036
108 GLN 133 ALA 1.033 0.000 1.033 1.033
83 PRO 107 GLY 1.031 0.000 1.031 1.031
48 LEU 65 ASP 1.628 0.603 1.025 1.025
260 GLN 306 LYS 0.000 1.025 -1.025 1.025
929 GLN 930 PRO 1.465 0.441 1.024 1.024
259 LEU 283 LEU 4.523 5.546 -1.023 1.023
172 ASN 195 LEU 0.000 1.022 -1.022 1.022
737 VAL 793 SER 1.182 2.203 -1.022 1.022
261 GLU 287 HIS 0.000 1.021 -1.021 1.021
711 TYR 718 LEU 1.201 0.183 1.019 1.019
264 PHE 269 ILE 2.138 1.119 1.019 1.019
559 PHE 622 ASP 12.132 11.113 1.019 1.019
100 ASN 124 ASN 7.074 8.088 -1.014 1.014
68 THR 92 LEU 4.003 5.016 -1.013 1.013
118 ILE 120 MET 1.131 0.118 1.013 1.013
354 LEU 376 LEU 4.327 5.335 -1.008 1.008
703 LEU 732 PHE 2.635 1.627 1.008 1.008
298 ARG 320 GLU 5.933 4.930 1.003 1.003
249 PHE 269 ILE 0.527 1.530 -1.003 1.003
34 ALA 63 ASP 0.000 1.002 -1.002 1.002
308 HIS 332 ILE 3.596 2.598 0.998 0.998
26 PRO 27 GLN 0.000 0.997 -0.997 0.997
253 ILE 277 PHE 0.000 0.997 -0.997 0.997
465 PHE 482 TYR 2.466 1.470 0.996 0.996
721 ALA 729 ALA 0.000 0.995 -0.995 0.995
798 LEU 800 LEU 0.908 1.902 -0.995 0.995
131 ALA 135 TRP 0.000 0.989 -0.989 0.989
132 GLU 135 TRP 0.567 1.556 -0.989 0.989
360 SER 384 ASN 0.115 1.101 -0.986 0.986
239 LEU 262 LEU 4.081 3.095 0.986 0.986
260 GLN 283 LEU 3.948 4.933 -0.985 0.985
94 GLU 118 ILE 5.789 6.774 -0.985 0.985
373 CYS 397 LEU 2.443 1.461 0.982 0.982
82 GLN 83 PRO 0.628 1.610 -0.982 0.982
253 ILE 264 PHE 0.982 0.000 0.982 0.982
658 LEU 693 CYS 3.454 4.434 -0.980 0.980
332 ILE 356 VAL 3.262 2.282 0.979 0.979
93 GLU 117 LYS 11.535 12.514 -0.979 0.979
789 VAL 811 VAL 0.000 0.979 -0.979 0.979
270 LYS 292 PRO 2.408 3.386 -0.978 0.978
796 SER 801 PHE 0.977 0.000 0.977 0.977
322 PRO 335 LEU 0.158 1.134 -0.977 0.977
245 LYS 268 ASN 0.643 1.618 -0.975 0.975
557 TYR 565 ARG 1.621 0.650 0.971 0.971
139 SER 187 ALA 0.968 0.000 0.968 0.968
315 ALA 339 GLY 0.968 0.000 0.968 0.968
261 GLU 283 LEU 0.000 0.963 -0.963 0.963
778 LEU 826 LEU 0.410 1.373 -0.962 0.962
298 ARG 322 PRO 0.288 1.249 -0.961 0.961
147 ALA 196 ASN 0.961 0.000 0.961 0.961
79 THR 101 HIS 2.674 3.635 -0.960 0.960
391 ALA 416 GLU 1.426 0.467 0.960 0.960
309 THR 332 ILE 5.129 4.170 0.959 0.959
36 PRO 61 PRO 0.410 1.368 -0.958 0.958
161 LEU 185 LEU 0.000 0.956 -0.956 0.956
249 PHE 250 PRO 2.222 3.178 -0.956 0.956
674 VAL 680 SER 0.000 0.953 -0.953 0.953
883 SER 884 GLU 0.000 0.952 -0.952 0.952
186 PRO 210 THR 0.000 0.950 -0.950 0.950
585 THR 834 PHE 3.053 2.104 0.949 0.949
196 ASN 220 ASN 10.792 9.848 0.944 0.944
403 LEU 427 LEU 4.461 3.521 0.940 0.940
553 LYS 637 GLU 5.374 6.311 -0.937 0.937
154 PRO 202 PRO 0.935 0.000 0.935 0.935
477 TYR 553 LYS 6.354 7.287 -0.933 0.933
714 SER 715 PRO 0.861 1.793 -0.932 0.932
751 TYR 754 LEU 0.175 1.105 -0.930 0.930
281 PRO 305 PRO 0.916 1.845 -0.928 0.928
445 LEU 448 LEU 2.015 1.091 0.924 0.924
281 PRO 303 TYR 0.000 0.923 -0.923 0.923
730 LEU 797 MET 0.923 0.000 0.923 0.923
134 LEU 157 SER 0.000 0.919 -0.919 0.919
188 LEU 212 LEU 4.866 5.784 -0.917 0.917
468 LEU 482 TYR 1.780 0.863 0.917 0.917
178 PRO 182 LEU 0.000 0.917 -0.917 0.917
249 PHE 288 PHE 0.915 0.000 0.915 0.915
330 LEU 351 LEU 1.761 0.849 0.912 0.912
221 ARG 245 LYS 1.750 0.838 0.912 0.912
773 ARG 777 TRP 0.000 0.910 -0.910 0.910
247 GLN 268 ASN 3.764 2.858 0.906 0.906
128 GLY 152 LEU 0.000 0.906 -0.906 0.906
260 GLN 285 THR 2.941 2.038 0.903 0.903
357 LEU 359 LEU 2.002 2.905 -0.903 0.903
461 SER 463 ASP 0.478 1.379 -0.901 0.901
265 HIS 291 ASN 0.707 1.606 -0.899 0.899
392 ASP 395 SER 0.898 0.000 0.898 0.898
70 TYR 96 ARG 7.578 8.474 -0.896 0.896
213 VAL 237 GLU 6.349 5.457 0.892 0.892
480 CYS 630 SER 0.668 1.559 -0.891 0.891
191 MET 216 HIS 3.501 2.610 0.891 0.891
564 ILE 813 LEU 0.272 1.162 -0.890 0.890
804 THR 806 GLU 0.990 1.880 -0.890 0.890
86 PHE 109 ALA 1.729 2.619 -0.890 0.890
257 GLY 282 LEU 1.673 0.786 0.886 0.886
360 SER 382 GLN 7.368 8.254 -0.886 0.886
411 ARG 435 THR 1.594 0.710 0.884 0.884
380 GLY 404 ASP 1.922 1.039 0.883 0.883
70 TYR 94 GLU 7.269 6.387 0.882 0.882
127 GLY 176 GLU 0.881 0.000 0.881 0.881
237 GLU 260 GLN 10.657 11.538 -0.880 0.880
371 HIS 395 SER 4.382 3.503 0.880 0.880
457 SER 635 ARG 0.369 1.248 -0.879 0.879
564 ILE 814 VAL 0.000 0.873 -0.873 0.873
91 PHE 115 SER 1.585 2.458 -0.873 0.873
647 PHE 711 TYR 5.163 6.036 -0.873 0.873
140 LEU 185 LEU 0.872 0.000 0.872 0.872
286 ILE 307 LEU 1.845 0.974 0.871 0.871
98 SER 124 ASN 0.146 1.017 -0.871 0.871
716 LEU 813 LEU 1.735 0.865 0.871 0.871
923 ASN 924 HIS 0.000 0.870 -0.870 0.870
437 LEU 450 LEU 0.404 1.274 -0.870 0.870
134 LEU 181 ALA 0.869 0.000 0.869 0.869
516 ALA 517 ARG 0.000 0.868 -0.868 0.868
259 LEU 280 ASN 0.734 1.602 -0.868 0.868
201 ILE 229 SER 1.117 1.985 -0.867 0.867
833 HIS 836 ASP 0.000 0.865 -0.865 0.865
629 PHE 715 PRO 1.331 2.196 -0.865 0.865
110 PHE 119 LEU 1.278 2.142 -0.865 0.865
148 ASN 150 ILE 1.692 0.828 0.864 0.864
803 VAL 807 ALA 1.000 0.136 0.864 0.864
485 CYS 555 CYS 0.250 1.114 -0.863 0.863
177 ILE 205 ALA 0.000 0.863 -0.863 0.863
153 VAL 158 PHE 0.000 0.862 -0.862 0.862
57 LEU 77 ASN 5.043 5.902 -0.859 0.859
130 PRO 132 GLU 0.859 0.000 0.859 0.859
149 LEU 175 THR 0.855 0.000 0.855 0.855
803 VAL 808 VAL 1.755 0.900 0.855 0.855
567 ALA 814 VAL 0.000 0.852 -0.852 0.852
312 LEU 336 THR 4.182 3.330 0.852 0.852
153 VAL 181 ALA 0.000 0.849 -0.849 0.849
206 PHE 229 SER 2.673 1.825 0.849 0.849
106 PRO 130 PRO 0.848 0.000 0.848 0.848
264 PHE 277 PHE 0.000 0.848 -0.848 0.848
289 TYR 290 ASP 0.000 0.846 -0.846 0.846
753 LYS 757 ASP 2.774 1.928 0.845 0.845
277 PHE 288 PHE 0.845 0.000 0.845 0.845
940 ALA 941 GLU 0.374 1.217 -0.843 0.843
182 LEU 191 MET 0.784 1.625 -0.841 0.841
382 GLN 383 HIS 1.106 0.269 0.837 0.837
84 GLY 111 SER 0.837 0.000 0.837 0.837
785 LEU 818 LEU 2.491 1.655 0.836 0.836
107 GLY 130 PRO 0.836 0.000 0.836 0.836
143 LEU 145 LEU 1.293 2.128 -0.834 0.834
489 PHE 551 PRO 0.832 0.000 0.832 0.832
174 LEU 176 GLU 0.830 0.000 0.830 0.830
244 ASN 267 ASN 9.765 8.935 0.829 0.829
147 ALA 172 ASN 0.000 0.820 -0.820 0.820
722 PRO 730 LEU 0.820 0.000 0.820 0.820
489 PHE 549 PRO 0.817 0.000 0.817 0.817
150 ILE 175 THR 0.816 0.000 0.816 0.816
52 CYS 72 ASP 4.588 5.403 -0.815 0.815
476 ALA 553 LYS 0.000 0.814 -0.814 0.814
227 THR 228 HIS 2.688 1.874 0.814 0.814
356 VAL 376 LEU 0.000 0.814 -0.814 0.814
155 GLU 180 ARG 11.944 11.130 0.813 0.813
557 TYR 622 ASP 0.000 0.812 -0.812 0.812
119 LEU 121 LEU 0.743 1.555 -0.812 0.812
406 SER 407 TRP 2.105 1.298 0.807 0.807
197 ARG 220 ASN 1.058 1.864 -0.807 0.807
82 GLN 106 PRO 0.852 0.046 0.807 0.807
198 ILE 222 ILE 4.534 3.728 0.806 0.806
827 TYR 834 PHE 1.021 0.216 0.806 0.806
410 ILE 432 ASN 8.316 7.513 0.803 0.803
158 PHE 184 ASN 0.000 0.802 -0.802 0.802
654 GLU 739 MET 1.523 2.324 -0.802 0.802
286 ILE 301 PHE 1.158 0.357 0.801 0.801
283 LEU 286 ILE 2.033 1.232 0.801 0.801
220 ASN 243 TYR 0.208 1.008 -0.801 0.801
305 PRO 329 SER 4.340 3.540 0.800 0.800
476 ALA 549 PRO 3.085 2.291 0.795 0.795
559 PHE 618 LEU 1.559 2.352 -0.793 0.793
462 LYS 481 PRO 1.586 0.793 0.792 0.792
446 MET 469 ARG 4.512 5.304 -0.792 0.792
219 ASN 244 ASN 1.250 0.459 0.791 0.791
199 SER 223 GLN 3.250 2.460 0.790 0.790
277 PHE 301 PHE 4.084 3.296 0.789 0.789
758 LEU 759 PRO 1.451 0.662 0.788 0.788
249 PHE 271 ALA 1.529 0.745 0.784 0.784
254 ARG 274 GLU 0.784 0.000 0.784 0.784
250 PRO 253 ILE 1.339 0.556 0.783 0.783
559 PHE 568 VAL 0.637 1.419 -0.782 0.782
318 ILE 340 ILE 3.457 2.676 0.781 0.781
945 PRO 946 ALA 0.779 0.000 0.779 0.779
660 LEU 827 TYR 0.779 0.000 0.779 0.779
460 PHE 481 PRO 1.525 2.302 -0.777 0.777
611 THR 820 ALA 0.372 1.148 -0.776 0.776
426 LYS 447 HIS 2.739 3.512 -0.774 0.774
737 VAL 790 ALA 0.918 0.147 0.771 0.771
357 LEU 376 LEU 0.277 1.047 -0.770 0.770
737 VAL 797 MET 0.768 0.000 0.768 0.768
149 LEU 196 ASN 0.768 0.000 0.768 0.768
33 THR 43 GLU 0.039 0.806 -0.768 0.768
89 LEU 113 LEU 1.081 1.848 -0.767 0.767
129 ILE 152 LEU 0.000 0.765 -0.765 0.765
764 GLU 767 TRP 0.764 0.000 0.764 0.764
909 ALA 910 PRO 1.000 1.762 -0.762 0.762
295 PHE 317 ASP 0.000 0.761 -0.761 0.761
239 LEU 261 GLU 3.329 2.570 0.759 0.759
183 ASN 205 ALA 0.759 0.000 0.759 0.759
556 GLU 625 THR 0.000 0.758 -0.758 0.758
338 ALA 361 HIS 0.472 1.229 -0.757 0.757
192 THR 194 ALA 0.031 0.788 -0.756 0.756
651 LEU 697 ALA 2.314 1.561 0.754 0.754
193 LEU 216 HIS 4.045 3.293 0.751 0.751
230 PHE 241 LEU 0.009 0.755 -0.746 0.746
666 GLN 686 VAL 5.649 4.906 0.743 0.743
149 LEU 173 ALA 0.000 0.742 -0.742 0.742
607 ALA 652 GLY 4.326 3.586 0.740 0.740
145 LEU 177 ILE 0.739 0.000 0.739 0.739
477 TYR 637 GLU 6.953 6.216 0.738 0.738
130 PRO 133 ALA 0.832 0.094 0.737 0.737
276 ALA 300 ALA 1.611 2.348 -0.737 0.737
720 TYR 733 THR 1.665 0.929 0.736 0.736
182 LEU 206 PHE 0.132 0.866 -0.734 0.734
637 GLU 642 CYS 2.117 1.384 0.733 0.733
555 CYS 628 GLN 0.000 0.730 -0.730 0.730
60 VAL 85 LEU 2.789 2.061 0.728 0.728
575 SER 821 CYS 1.674 2.403 -0.728 0.728
359 LEU 382 GLN 0.725 0.000 0.725 0.725
260 GLN 282 LEU 1.916 2.640 -0.724 0.724
382 GLN 408 ASN 0.449 1.168 -0.719 0.719
343 LEU 347 MET 0.719 0.000 0.719 0.719
376 LEU 379 ILE 1.923 1.204 0.719 0.719
270 LYS 295 PHE 2.167 1.450 0.717 0.717
158 PHE 176 GLU 0.716 0.000 0.716 0.716
569 TRP 620 SER 1.682 0.972 0.710 0.710
394 PHE 418 PHE 1.711 1.002 0.709 0.709
304 LEU 326 GLY 2.618 1.910 0.708 0.708
422 HIS 441 GLY 0.708 0.000 0.708 0.708
56 GLY 76 ASN 2.524 3.230 -0.706 0.706
140 LEU 161 LEU 0.000 0.706 -0.706 0.706
379 ILE 404 ASP 3.768 3.066 0.702 0.702
316 MET 338 ALA 0.088 0.786 -0.698 0.698
562 TRP 626 PHE 0.509 1.207 -0.698 0.698
14 ALA 15 ALA 0.000 0.696 -0.696 0.696
659 LEU 693 CYS 0.863 1.559 -0.695 0.695
571 ILE 821 CYS 2.304 1.610 0.694 0.694
324 LEU 327 THR 0.999 0.305 0.694 0.694
552 PHE 812 LEU 0.000 0.694 -0.694 0.694
401 GLN 426 LYS 3.079 3.773 -0.694 0.694
134 LEU 185 LEU 0.694 0.000 0.694 0.694
468 LEU 543 VAL 2.927 3.621 -0.694 0.694
264 PHE 286 ILE 0.000 0.694 -0.694 0.694
670 SER 681 PRO 2.304 2.997 -0.694 0.694
629 PHE 636 TRP 1.054 0.360 0.693 0.693
598 LYS 834 PHE 0.691 0.000 0.691 0.691
114 TYR 139 SER 3.502 2.813 0.689 0.689
598 LYS 837 ASP 3.017 3.705 -0.688 0.688
92 LEU 116 LEU 4.665 5.353 -0.688 0.688
270 LYS 293 ILE 2.465 3.153 -0.687 0.687
242 ASN 522 HIS 0.684 0.000 0.684 0.684
309 THR 330 LEU 1.038 1.722 -0.684 0.684
395 SER 396 GLN 0.112 0.793 -0.682 0.682
262 LEU 264 PHE 2.837 2.155 0.681 0.681
264 PHE 291 ASN 2.356 3.036 -0.679 0.679
239 LEU 263 GLY 2.160 2.838 -0.678 0.678
504 ASP 505 GLU 0.000 0.677 -0.677 0.677
378 GLU 402 ALA 3.055 3.732 -0.676 0.676
206 PHE 233 LEU 3.656 2.980 0.676 0.676
171 ASP 196 ASN 0.000 0.675 -0.675 0.675
394 PHE 405 LEU 0.065 0.740 -0.674 0.674
314 GLY 337 ARG 1.536 2.210 -0.674 0.674
460 PHE 478 GLN 0.130 0.804 -0.674 0.674
174 LEU 193 LEU 0.000 0.673 -0.673 0.673
571 ILE 817 PRO 2.309 1.643 0.665 0.665
936 LEU 937 LEU 2.354 3.015 -0.662 0.662
404 ASP 428 ASP 4.709 4.049 0.660 0.660
341 ARG 365 GLU 0.778 1.437 -0.659 0.659
102 LEU 125 GLN 4.682 5.342 -0.659 0.659
213 VAL 236 LEU 5.142 5.800 -0.658 0.658
586 VAL 598 LYS 1.083 1.741 -0.658 0.658
50 ALA 68 THR 1.229 0.572 0.658 0.658
126 LEU 145 LEU 0.000 0.655 -0.655 0.655
283 LEU 306 LYS 3.591 4.246 -0.654 0.654
345 SER 368 PRO 0.505 1.158 -0.653 0.653
76 ASN 99 GLY 1.289 1.941 -0.653 0.653
381 LEU 386 ILE 0.652 1.304 -0.652 0.652
451 LYS 473 VAL 0.579 1.230 -0.651 0.651
664 ALA 751 TYR 0.620 1.272 -0.651 0.651
79 THR 104 HIS 0.651 0.000 0.651 0.651
25 ALA 26 PRO 0.786 1.436 -0.650 0.650
565 ARG 569 TRP 0.000 0.648 -0.648 0.648
343 LEU 368 PRO 2.497 3.145 -0.648 0.648
430 THR 451 LYS 5.196 4.549 0.648 0.648
565 ARG 622 ASP 7.202 7.849 -0.647 0.647
215 LEU 238 THR 3.570 2.927 0.643 0.643
94 GLU 96 ARG 5.983 6.625 -0.643 0.643
777 TRP 826 LEU 1.950 1.308 0.642 0.642
336 THR 362 ASN 0.303 0.944 -0.641 0.641
558 LEU 618 LEU 1.039 0.399 0.641 0.641
73 LEU 97 LEU 1.876 1.235 0.640 0.640
189 GLN 214 VAL 3.097 2.457 0.640 0.640
207 GLN 208 ASN 0.638 0.000 0.638 0.638
117 LYS 142 SER 3.206 3.844 -0.638 0.638
303 TYR 326 GLY 1.714 2.352 -0.638 0.638
818 LEU 821 CYS 0.000 0.637 -0.637 0.637
569 TRP 619 ALA 5.728 6.364 -0.636 0.636
604 ILE 656 SER 0.217 0.852 -0.635 0.635
419 SER 441 GLY 2.031 2.665 -0.635 0.635
705 LEU 711 TYR 2.045 1.411 0.635 0.635
330 LEU 333 LEU 0.498 1.133 -0.634 0.634
716 LEU 718 LEU 0.633 0.000 0.633 0.633
352 PRO 375 LYS 1.337 0.705 0.632 0.632
726 GLN 729 ALA 0.630 0.000 0.630 0.630
70 TYR 92 LEU 0.999 1.629 -0.629 0.629
386 ILE 389 ILE 0.045 0.674 -0.629 0.629
457 SER 631 GLU 0.627 0.000 0.627 0.627
650 VAL 700 ALA 0.977 0.351 0.627 0.627
721 ALA 733 THR 0.000 0.626 -0.626 0.626
76 ASN 100 ASN 10.062 10.686 -0.624 0.624
394 PHE 420 THR 1.361 0.738 0.623 0.623
394 PHE 417 ALA 1.975 1.357 0.618 0.618

RRCS change distribution

-0.22
Mean ΔRRCS
1.66
Std Dev
-0.07
Median

Magnitude classification

56
High (|Δ| ≥ 5.0)
219
Medium (2.3 ≤ |Δ| < 5.0)
2107
Low (|Δ| < 2.3)

Methods

RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).

Significance threshold. |ΔRRCS| ≥ 2.34, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.

Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.

Structural annotation. TM domain boundaries and generic numbering from GPCRdb.

What is RRCS?

Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.

ΔRRCS (Delta RRCS) shows the difference in contact strength between states:

  • Positive ΔRRCS. Contact is stronger in the active state.
  • Negative ΔRRCS. Contact is stronger in the inactive state.
  • Large |ΔRRCS|. Significant structural rearrangement.

Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.

Pathogenicity predictions

AlphaMissense predicts whether a mutation harms protein function:

  • Pathogenic (score ≥ 0.564): mutation likely damages function.
  • Ambiguous (0.34–0.563): effect uncertain.
  • Benign (< 0.34): mutation likely tolerated.

Conservation & population data

Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.

Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.

Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar