OPN5
847
Total Contact Pairs
91
Significant Changes
14.08
Max Increase
-14.77
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | TRP143 (34.55x55) | HIS148 (4.41x41) | 0.000 | 14.771 | -14.771 | HIGH |
| 2 | ARG131 (3.50x50) | ASP310 (8.47x47) | 14.082 | 0.000 | +14.082 | HIGH |
| 3 | ARG61 (1.60x60) | TYR311 (8.48x48) | 13.139 | 0.000 | +13.139 | HIGH |
| 4 | PHE89 (2.60x59) | PHE101 (23.52x52) | 0.000 | 12.520 | -12.520 | HIGH |
| 5 | TRP187 | SER272 (6.55x55) | 0.000 | 12.102 | -12.102 | HIGH |
| 6 | PHE24 | TRP99 (23.50x50) | 0.000 | 11.004 | -11.004 | HIGH |
| 7 | TYR219 (5.58x58) | MET255 (6.38x38) | 0.000 | 10.574 | -10.574 | HIGH |
| 8 | TRP111 (3.30x30) | TYR174 | 0.000 | 10.358 | -10.358 | HIGH |
| 9 | ARG107 (3.26x26) | LEU171 | 9.673 | 0.000 | +9.673 | HIGH |
| 10 | ARG61 (1.60x60) | HIS335 | 0.000 | 9.314 | -9.314 | HIGH |
| 11 | VAL54 (1.53x53) | GLN307 (7.54x54) | 9.048 | 0.000 | +9.048 | HIGH |
| 12 | TRP103 (3.22x22) | ASP173 | 8.915 | 0.000 | +8.915 | HIGH |
| 13 | SER26 | HIS97 (2.68x67) | 0.000 | 8.862 | -8.862 | HIGH |
| 14 | ARG107 (3.26x26) | ASP173 | 0.000 | 8.747 | -8.747 | HIGH |
| 15 | SER93 (2.64x63) | ARG98 (23.49x49) | 0.000 | 8.493 | -8.493 | HIGH |
| 16 | PHE24 | TRP103 (3.22x22) | 0.000 | 8.405 | -8.405 | HIGH |
| 17 | LEU171 | PHE199 (5.38x39) | 0.000 | 7.682 | -7.682 | HIGH |
| 18 | TRP30 (1.29x29) | GLU31 (1.30x30) | 8.005 | 0.480 | +7.525 | HIGH |
| 19 | ARG131 (3.50x50) | GLU247 (6.30x30) | 0.000 | 7.418 | -7.418 | HIGH |
| 20 | ARG19 | ASP281 | 0.000 | 7.225 | -7.225 | HIGH |
| 21 | GLY110 (3.29x29) | TYR174 | 0.000 | 7.131 | -7.131 | HIGH |
| 22 | PRO167 (4.60x60) | GLY172 | 0.000 | 7.119 | -7.119 | HIGH |
| 23 | TRP111 (3.30x30) | LEU168 (4.61x61) | 9.548 | 2.631 | +6.917 | HIGH |
| 24 | HIS16 | TRP188 | 0.000 | 6.777 | -6.777 | HIGH |
| 25 | VAL175 | THR184 (45.51x51) | 0.000 | 6.775 | -6.775 | HIGH |
| 26 | TYR219 (5.58x58) | ILE257 (6.40x40) | 6.656 | 0.000 | +6.656 | HIGH |
| 27 | GLY172 | ASP186 | 6.558 | 0.000 | +6.558 | HIGH |
| 28 | TRP103 (3.22x22) | ILE104 (3.23x23) | 6.396 | 0.000 | +6.396 | HIGH |
| 29 | LEU185 (45.52x52) | TRP187 | 8.853 | 2.507 | +6.345 | HIGH |
| 30 | TYR109 (3.28x28) | CYS183 (45.50x50) | 0.000 | 6.177 | -6.177 | HIGH |
| 31 | LYS249 (6.32x32) | PHE313 (8.50x50) | 3.546 | 9.614 | -6.068 | HIGH |
| 32 | GLU177 | PHE179 | 0.000 | 6.049 | -6.049 | HIGH |
| 33 | GLU177 | SER182 | 0.000 | 6.025 | -6.025 | HIGH |
| 34 | ASP33 (1.32x32) | CYS94 (2.65x64) | 0.000 | 6.020 | -6.020 | HIGH |
| 35 | PHE261 (6.44x44) | TRP265 (6.48x48) | 4.539 | 10.537 | -5.997 | HIGH |
| 36 | ASP310 (8.47x47) | LEU334 | 0.000 | 5.886 | -5.886 | HIGH |
| 37 | TRP30 (1.29x29) | HIS97 (2.68x67) | 0.000 | 5.845 | -5.845 | HIGH |
| 38 | PRO88 (2.59x58) | TYR109 (3.28x28) | 5.840 | 0.000 | +5.840 | HIGH |
| 39 | ALA190 | GLN197 (5.36x37) | 0.544 | 6.138 | -5.594 | HIGH |
| 40 | ARG131 (3.50x50) | THR251 (6.34x34) | 0.000 | 5.555 | -5.555 | HIGH |
| 41 | THR212 (5.51x51) | PHE261 (6.44x44) | 5.513 | 0.000 | +5.513 | HIGH |
| 42 | TYR174 | SER182 | 5.420 | 0.000 | +5.420 | HIGH |
| 43 | PHE114 (3.33x33) | THR164 (4.57x57) | 2.214 | 7.623 | -5.409 | HIGH |
| 44 | TRP187 | PHE199 (5.38x39) | 5.409 | 0.000 | +5.409 | HIGH |
| 45 | ARG19 | ASP20 | 0.000 | 5.394 | -5.394 | HIGH |
| 46 | SER230 (5.69x69) | GLU247 (6.30x30) | 5.363 | 0.000 | +5.363 | HIGH |
| 47 | SER93 (2.64x63) | TRP99 (23.50x50) | 0.000 | 5.135 | -5.135 | HIGH |
| 48 | LYS63 (12.48x48) | THR338 | 0.000 | 5.072 | -5.072 | HIGH |
| 49 | ILE92 (2.63x62) | HIS97 (2.68x67) | 5.011 | 0.000 | +5.011 | HIGH |
| 50 | LYS147 (4.40x40) | HIS148 (4.41x41) | 0.000 | 4.927 | -4.927 | MED |
| 51 | TRP103 (3.22x22) | ARG107 (3.26x26) | 4.891 | 0.000 | +4.891 | MED |
| 52 | THR164 (4.57x57) | TYR174 | 0.000 | 4.846 | -4.846 | MED |
| 53 | TYR56 (1.55x55) | ARG60 (1.59x59) | 7.978 | 3.207 | +4.772 | MED |
| 54 | ILE304 (7.51x51) | ILE309 (7.56x56) | 4.502 | 0.000 | +4.502 | MED |
| 55 | LEU189 | GLY196 (5.35x36) | 0.000 | 4.498 | -4.498 | MED |
| 56 | LEU204 (5.43x44) | SER272 (6.55x55) | 4.443 | 0.000 | +4.443 | MED |
| 57 | THR90 (2.61x60) | TYR109 (3.28x28) | 0.000 | 4.442 | -4.442 | MED |
| 58 | ASP130 (3.49x49) | ARG131 (3.50x50) | 0.000 | 4.404 | -4.404 | MED |
| 59 | LEU28 | GLN286 (7.33x32) | 4.387 | 0.000 | +4.387 | MED |
| 60 | TYR17 | VAL175 | 0.000 | 4.366 | -4.366 | MED |
| 61 | PRO178 | PHE179 | 4.316 | 0.000 | +4.316 | MED |
| 62 | VAL175 | CYS183 (45.50x50) | 0.000 | 4.304 | -4.304 | MED |
| 63 | MET166 (4.59x59) | LEU171 | 0.000 | 4.287 | -4.287 | MED |
| 64 | GLU177 | THR184 (45.51x51) | 0.000 | 4.248 | -4.248 | MED |
| 65 | MET124 (3.43x43) | PHE261 (6.44x44) | 1.253 | 5.474 | -4.222 | MED |
| 66 | ASP33 (1.32x32) | SER93 (2.64x63) | 4.206 | 0.000 | +4.206 | MED |
| 67 | ARG131 (3.50x50) | TYR219 (5.58x58) | 4.207 | 0.007 | +4.199 | MED |
| 68 | GLY102 (3.21x21) | ASP173 | 4.084 | 0.000 | +4.084 | MED |
| 69 | TRP30 (1.29x29) | LEU34 (1.33x33) | 0.000 | 4.046 | -4.046 | MED |
| 70 | SER26 | ASP33 (1.32x32) | 0.000 | 4.012 | -4.012 | MED |
| 71 | HIS16 | PRO178 | 0.000 | 4.008 | -4.008 | MED |
| 72 | TRP188 | SER275 (6.58x58) | 0.000 | 3.992 | -3.992 | MED |
| 73 | TRP111 (3.30x30) | THR165 (4.58x58) | 0.000 | 3.972 | -3.972 | MED |
| 74 | ILE257 (6.40x40) | ASN302 (7.49x49) | 0.000 | 3.951 | -3.951 | MED |
| 75 | THR72 (2.43x43) | TYR306 (7.53x53) | 0.300 | 4.194 | -3.894 | MED |
| 76 | SER93 (2.64x63) | THR181 | 0.000 | 3.840 | -3.840 | MED |
| 77 | THR41 (1.40x40) | ILE91 (2.62x61) | 0.000 | 3.835 | -3.835 | MED |
| 78 | ILE92 (2.63x62) | TRP99 (23.50x50) | 3.827 | 0.000 | +3.827 | MED |
| 79 | GLN191 | ALA276 (6.59x59) | 0.000 | 3.807 | -3.807 | MED |
| 80 | GLY86 (2.57x56) | TYR109 (3.28x28) | 0.000 | 3.753 | -3.753 | MED |
| 81 | TRP99 (23.50x50) | CYS183 (45.50x50) | 5.496 | 1.744 | +3.752 | MED |
| 82 | TYR17 | ASP186 | 0.000 | 3.710 | -3.710 | MED |
| 83 | PHE179 | VAL289 (7.36x35) | 0.000 | 3.699 | -3.699 | MED |
| 84 | GLU348 | ILE349 | 0.000 | 3.691 | -3.691 | MED |
| 85 | VAL175 | ASP186 | 0.000 | 3.663 | -3.663 | MED |
| 86 | GLY170 (4.63x63) | ASP186 | 3.652 | 0.000 | +3.652 | MED |
| 87 | PHE24 | ARG98 (23.49x49) | 0.000 | 3.561 | -3.561 | MED |
| 88 | TYR109 (3.28x28) | LYS296 (7.43x42) | 0.000 | 3.495 | -3.495 | MED |
| 89 | PRO167 (4.60x60) | TYR174 | 0.000 | 3.485 | -3.485 | MED |
| 90 | TRP187 | ALA276 (6.59x59) | 0.000 | 3.461 | -3.461 | MED |
| 91 | SER229 (5.68x68) | GLU232 (5.71x71) | 0.132 | 3.566 | -3.434 | MED |
| 92 | ASP237 | ARG239 (6.22x22) | 3.396 | 0.000 | +3.396 | LOW |
| 93 | SER29 (1.28x28) | GLU31 (1.30x30) | 0.000 | 3.394 | -3.394 | LOW |
| 94 | LEU8 | GLU12 | 0.368 | 3.755 | -3.387 | LOW |
| 95 | GLN191 | GLN197 (5.36x37) | 3.377 | 0.000 | +3.377 | LOW |
| 96 | ARG131 (3.50x50) | LYS134 (3.53x53) | 0.000 | 3.375 | -3.375 | LOW |
| 97 | SER230 (5.69x69) | HIS244 (6.27x27) | 3.368 | 0.000 | +3.368 | LOW |
| 98 | ARG131 (3.50x50) | TYR306 (7.53x53) | 3.362 | 0.000 | +3.362 | LOW |
| 99 | GLY170 (4.63x63) | TRP187 | 3.345 | 0.000 | +3.345 | LOW |
| 100 | LYS134 (3.53x53) | GLY141 (34.53x53) | 0.000 | 3.337 | -3.337 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 3.41 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 29-61 | 61 (13.1), 54 (9.0), 30 (7.5), 31 (7.5), 56 (4.8), 60 (4.8) | 6 | 33 (-6.0), 34 (-4.0), 41 (-3.8) | 3 |
| TM2 | 69-97 | 88 (5.8), 92 (5.0) | 2 | 89 (-12.5), 97 (-8.9), 93 (-8.5), 94 (-6.0), 90 (-4.4), 72 (-3.9), 91 (-3.8), 86 (-3.8) | 8 |
| TM3 | 102-134 | 131 (14.1), 107 (9.7), 103 (8.9), 104 (6.4), 102 (4.1) | 5 | 111 (-10.4), 110 (-7.1), 109 (-6.2), 114 (-5.4), 130 (-4.4), 124 (-4.2) | 6 |
| TM4 | 147-170 | 168 (6.9), 170 (3.7) | 2 | 148 (-14.8), 167 (-7.1), 164 (-5.4), 147 (-4.9), 166 (-4.3), 165 (-4.0) | 6 |
| TM5 | 196-232 | 212 (5.5), 230 (5.4), 204 (4.4) | 3 | 219 (-10.6), 199 (-7.7), 197 (-5.6), 196 (-4.5), 229 (-3.4), 232 (-3.4) | 6 |
| TM6 | 239-276 | 257 (6.7) | 1 | 272 (-12.1), 255 (-10.6), 247 (-7.4), 249 (-6.1), 261 (-6.0), 265 (-6.0), 251 (-5.6), 275 (-4.0), 276 (-3.8) | 9 |
| TM7 | 286-309 | 307 (9.0), 304 (4.5), 309 (4.5), 286 (4.4) | 4 | 302 (-4.0), 306 (-3.9), 289 (-3.7), 296 (-3.5) | 4 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 63-66 | - | 0 | 63 (-5.1) | 1 |
| ICL2 | 141-143 | - | 0 | 143 (-14.8) | 1 |
| ICL3 | 237-237 | - | 0 | - | 0 |
| ECL1 | 98-101 | - | 0 | 101 (-12.5), 99 (-11.0), 98 (-8.5) | 3 |
| ECL2 | 171-191 | 171 (9.7), 173 (8.9), 186 (6.6), 185 (6.3), 178 (4.3) | 5 | 187 (-12.1), 174 (-10.4), 172 (-7.1), 188 (-6.8), 175 (-6.8), 184 (-6.8), 183 (-6.2), 177 (-6.0), 179 (-6.0), 182 (-6.0), 190 (-5.6), 189 (-4.5), 181 (-3.8), 191 (-3.8) | 14 |
| ECL3 | 281-281 | - | 0 | 281 (-7.2) | 1 |
| H8 | 310-313 | 310 (14.1), 311 (13.1) | 2 | 313 (-6.1) | 1 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
111 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 148 | p.His148Asn | c.442C>A | 2.07e-06 | 3 / 0 | 14.77 | 0.290 | BENIGN | 0.87 | |
| 131 | p.Arg131Gln | c.392G>A | 2.74e-06 | 4 / 0 | 14.08 | 0.927 | PATHOGENIC | 0.88 | rs1349834900 |
| 61 | p.Arg61Gln | c.182G>A | 1.31e-05 | 19 / 0 | 13.14 | 0.151 | BENIGN | 0.76 | rs201533729 |
| 101 | p.Phe101Ser | c.302T>C | 6.84e-07 | 1 / 0 | 12.52 | 0.938 | PATHOGENIC | 0.89 | rs755177267 |
| 272 | p.Ser272Tyr | c.815C>A | 6.84e-07 | 1 / 0 | 12.10 | 0.985 | PATHOGENIC | 0.91 | |
| 255 | p.Met255Lys | c.764T>A | 6.84e-07 | 1 / 0 | 10.57 | 0.976 | PATHOGENIC | 0.68 | |
| 219 | p.Tyr219His | c.655T>C | 6.84e-07 | 1 / 0 | 10.57 | 0.957 | PATHOGENIC | 0.99 | |
| 255 | p.Met255Ile | c.765G>A | 1.37e-06 | 2 / 0 | 10.57 | - | nan | - | rs763362808 |
| 107 | p.Arg107Cys | c.319C>T | 7.53e-06 | 11 / 0 | 9.67 | 0.431 | AMBIGUOUS | 0.53 | rs1219866609 |
| 171 | p.Leu171Met | c.511C>A | 6.84e-07 | 1 / 0 | 9.67 | 0.169 | BENIGN | 0.48 | |
| 107 | p.Arg107His | c.320G>A | 8.89e-06 | 13 / 0 | 9.67 | - | nan | - | rs1303441120 |
| 335 | p.His335Pro | c.1004A>C | 6.85e-07 | 1 / 0 | 9.31 | 0.072 | BENIGN | 0.74 | |
| 54 | p.Val54Gly | c.161T>G | 6.86e-07 | 1 / 0 | 9.05 | 0.877 | PATHOGENIC | 0.98 | |
| 54 | p.Val54Ala | c.161T>C | 6.86e-07 | 1 / 0 | 9.05 | - | nan | - | rs1561888730 |
| 173 | p.Asp173His | c.517G>C | 6.84e-07 | 1 / 0 | 8.91 | 0.199 | BENIGN | 0.51 | |
| 173 | p.Asp173Gly | c.518A>G | 6.84e-07 | 1 / 0 | 8.91 | - | nan | - | |
| 98 | p.Arg98Ser | c.292C>A | 6.84e-07 | 1 / 0 | 8.49 | 0.669 | PATHOGENIC | 0.71 | |
| 98 | p.Arg98Cys | c.292C>T | 4.79e-06 | 7 / 0 | 8.49 | - | nan | - | rs145617365 |
| 98 | p.Arg98His | c.293G>A | 3.42e-06 | 5 / 0 | 8.49 | - | nan | - | rs1773384350 |
| 30 | p.Trp30Arg | c.88T>C | 6.84e-07 | 1 / 0 | 7.52 | 0.160 | BENIGN | 0.44 | |
| 30 | p.Trp30Gly | c.88T>G | 6.84e-07 | 1 / 0 | 7.52 | - | nan | - | |
| 19 | p.Arg19Gly | c.55C>G | 6.16e-06 | 9 / 0 | 7.23 | 0.132 | BENIGN | 0.47 | |
| 19 | p.Arg19Pro | c.56G>C | 6.57e-06 | 1 / 0 | 7.23 | - | nan | - | rs1240730978 |
| 19 | p.Arg19Gln | c.56G>A | 2.74e-06 | 4 / 0 | 7.23 | - | nan | - | rs1240730978 |
| 172 | p.Gly172Val | c.515G>T | 6.57e-06 | 1 / 0 | 7.12 | 0.938 | PATHOGENIC | 0.89 | rs1413712031 |
| 168 | p.Leu168Trp | c.503T>G | 6.84e-07 | 1 / 0 | 6.92 | 0.467 | AMBIGUOUS | 0.65 | |
| 188 | p.Trp188Arg | c.562T>C | 6.84e-07 | 1 / 0 | 6.78 | 0.594 | PATHOGENIC | 0.80 | rs1773513992 |
| 16 | p.His16Tyr | c.46C>T | 1.37e-06 | 2 / 0 | 6.78 | 0.100 | BENIGN | 0.84 | |
| 16 | p.His16Arg | c.47A>G | 2.53e-05 | 37 / 0 | 6.78 | - | nan | - | rs377432555 |
| 184 | p.Thr184Ala | c.550A>G | 6.84e-07 | 1 / 0 | 6.77 | 0.725 | PATHOGENIC | 0.92 | rs1773513415 |
| 175 | p.Val175Ile | c.523G>A | 1.23e-05 | 18 / 0 | 6.77 | 0.139 | BENIGN | 0.64 | rs780695747 |
| 104 | p.Ile104Met | c.312C>G | 6.84e-07 | 1 / 0 | 6.40 | 0.076 | BENIGN | 0.37 | |
| 185 | p.Leu185Val | c.553C>G | 6.84e-07 | 1 / 0 | 6.35 | 0.307 | BENIGN | 0.77 | |
| 109 | p.Tyr109Cys | c.326A>G | 2.74e-06 | 4 / 0 | 6.18 | 0.885 | PATHOGENIC | 0.89 | rs748559697 |
| 313 | p.Phe313Ser | c.938T>C | 5.47e-06 | 8 / 0 | 6.07 | 0.323 | BENIGN | 0.48 | rs1320473532 |
| 249 | p.Lys249Gln | c.745A>C | 6.85e-07 | 1 / 0 | 6.07 | 0.268 | BENIGN | 0.82 | |
| 177 | p.Glu177Ala | c.530A>C | 6.84e-07 | 1 / 0 | 6.05 | 0.944 | PATHOGENIC | 0.95 | |
| 33 | p.Asp33Ala | c.98A>C | 6.84e-07 | 1 / 0 | 6.02 | 0.988 | PATHOGENIC | 0.98 | |
| 94 | p.Cys94Gly | c.280T>G | 6.84e-07 | 1 / 0 | 6.02 | 0.472 | AMBIGUOUS | 0.53 | |
| 261 | p.Phe261Leu | c.781T>C | 6.84e-07 | 1 / 0 | 6.00 | 0.999 | PATHOGENIC | 1.00 | |
| 334 | p.Leu334Gln | c.1001T>A | 7.54e-06 | 11 / 0 | 5.89 | 0.068 | BENIGN | 0.52 | rs774001394 |
| 88 | p.Pro88Ser | c.262C>T | 6.84e-07 | 1 / 0 | 5.84 | 0.896 | PATHOGENIC | 0.93 | rs1189336023 |
| 88 | p.Pro88Thr | c.262C>A | 6.84e-07 | 1 / 0 | 5.84 | - | nan | - | |
| 88 | p.Pro88Leu | c.263C>T | 1.37e-06 | 2 / 0 | 5.84 | - | nan | - | rs758572074 |
| 190 | p.Ala190Pro | c.568G>C | 1.37e-06 | 2 / 0 | 5.59 | 0.496 | AMBIGUOUS | 0.64 | rs1172262178 |
| 190 | p.Ala190Ser | c.568G>T | 6.57e-06 | 1 / 0 | 5.59 | - | nan | - | rs1172262178 |
| 190 | p.Ala190Val | c.569C>T | 6.84e-07 | 1 / 0 | 5.59 | - | nan | - | rs1581735042 |
| 251 | p.Thr251Ala | c.751A>G | 6.86e-07 | 1 / 0 | 5.55 | 0.576 | PATHOGENIC | 0.88 | |
| 212 | p.Thr212Lys | c.635C>A | 6.57e-06 | 1 / 0 | 5.51 | 0.978 | PATHOGENIC | 0.71 | rs773340997 |
| 212 | p.Thr212Met | c.635C>T | 1.18e-04 | 172 / 0 | 5.51 | - | nan | - | rs773340997 |
| 114 | p.Phe114Val | c.340T>G | 6.84e-07 | 1 / 0 | 5.41 | 0.928 | PATHOGENIC | 0.92 | rs778478489 |
| 164 | p.Thr164Ala | c.490A>G | 6.84e-07 | 1 / 0 | 5.41 | 0.106 | BENIGN | 0.80 | |
| 114 | p.Phe114Leu | c.340T>C | 6.84e-07 | 1 / 0 | 5.41 | - | nan | - | rs778478489 |
| 20 | p.Asp20His | c.58G>C | 1.10e-05 | 16 / 0 | 5.39 | 0.136 | BENIGN | 0.51 | rs775797817 |
| 20 | p.Asp20Val | c.59A>T | 9.58e-06 | 14 / 0 | 5.39 | - | nan | - | rs1773107467 |
| 230 | p.Ser230Thr | c.688T>A | 3.42e-06 | 5 / 0 | 5.36 | 0.091 | BENIGN | 0.51 | rs1471692820 |
| 230 | p.Ser230Phe | c.689C>T | 5.47e-06 | 8 / 0 | 5.36 | - | nan | - | rs778780427 |
| 230 | p.Ser230Tyr | c.689C>A | 6.84e-07 | 1 / 0 | 5.36 | - | nan | - | |
| 338 | p.Thr338Ala | c.1012A>G | 6.85e-07 | 1 / 0 | 5.07 | 0.070 | BENIGN | 0.67 | rs756067884 |
| 338 | p.Thr338Ile | c.1013C>T | 6.85e-07 | 1 / 0 | 5.07 | - | nan | - | rs1224100656 |
| 92 | p.Ile92Thr | c.275T>C | 6.84e-07 | 1 / 0 | 5.01 | 0.363 | AMBIGUOUS | 0.61 | |
| 92 | p.Ile92Met | c.276C>G | 6.84e-07 | 1 / 0 | 5.01 | - | nan | - | rs1289920922 |
| 147 | p.Lys147Arg | c.440A>G | 3.46e-06 | 5 / 0 | 4.93 | 0.073 | BENIGN | 0.61 | rs774464271 |
| 60 | p.Arg60Gly | c.178A>G | 2.75e-05 | 40 / 0 | 4.77 | 0.309 | BENIGN | 0.75 | rs140514652 |
| 309 | p.Ile309Thr | c.926T>C | 6.57e-06 | 1 / 0 | 4.50 | 0.195 | BENIGN | 0.71 | rs1295284200 |
| 304 | p.Ile304Leu | c.910A>C | 6.84e-07 | 1 / 0 | 4.50 | 0.150 | BENIGN | 0.90 | rs748306671 |
| 196 | p.Gly196Val | c.587G>T | 6.84e-07 | 1 / 0 | 4.50 | 0.764 | PATHOGENIC | 0.78 | |
| 130 | p.Asp130Asn | c.388G>A | 6.84e-07 | 1 / 0 | 4.40 | 0.891 | PATHOGENIC | 0.71 | rs1322203175 |
| 28 | p.Leu28Pro | c.83T>C | 1.37e-06 | 2 / 0 | 4.39 | 0.975 | PATHOGENIC | 0.98 | |
| 286 | p.Gln286His | c.858G>C | 3.42e-06 | 5 / 0 | 4.39 | 0.209 | BENIGN | 0.48 | rs1239178606 |
| 17 | p.Tyr17Cys | c.50A>G | 1.37e-06 | 2 / 0 | 4.37 | 0.277 | BENIGN | 0.88 | |
| 178 | p.Pro178Ser | c.532C>T | 1.37e-06 | 2 / 0 | 4.32 | 0.842 | PATHOGENIC | 0.95 | rs1773512297 |
| 166 | p.Met166Leu | c.496A>C | 6.84e-07 | 1 / 0 | 4.29 | 0.158 | BENIGN | 0.66 | |
| 166 | p.Met166Val | c.496A>G | 2.05e-06 | 3 / 0 | 4.29 | - | nan | - | rs754199132 |
| 166 | p.Met166Arg | c.497T>G | 6.84e-07 | 1 / 0 | 4.29 | - | nan | - | |
| 166 | p.Met166Ile | c.498G>A | 6.84e-07 | 1 / 0 | 4.29 | - | nan | - | rs143358523 |
| 166 | p.Met166Ile | c.498G>C | 2.05e-06 | 3 / 0 | 4.29 | - | nan | - | rs143358523 |
| 302 | p.Asn302Ser | c.905A>G | 6.84e-07 | 1 / 0 | 3.95 | 0.751 | PATHOGENIC | 0.98 | |
| 306 | p.Tyr306Cys | c.917A>G | 1.37e-06 | 2 / 0 | 3.89 | 0.784 | PATHOGENIC | 0.97 | rs1774054650 |
| 72 | p.Thr72Ala | c.214A>G | 6.85e-07 | 1 / 0 | 3.89 | 0.419 | AMBIGUOUS | 0.84 | |
| 72 | p.Thr72Ile | c.215C>T | 3.42e-06 | 5 / 0 | 3.89 | - | nan | - | rs757212050 |
| 181 | p.Thr181Asn | c.542C>A | 6.84e-07 | 1 / 0 | 3.84 | 0.770 | PATHOGENIC | 0.83 | |
| 91 | p.Ile91Val | c.271A>G | 2.74e-06 | 4 / 0 | 3.83 | 0.127 | BENIGN | 0.71 | rs985983285 |
| 86 | p.Gly86Ser | c.256G>A | 6.84e-07 | 1 / 0 | 3.75 | 0.693 | PATHOGENIC | 0.89 | |
| 289 | p.Val289Leu | c.865G>C | 2.05e-06 | 3 / 0 | 3.70 | 0.481 | AMBIGUOUS | 0.78 | |
| 348 | p.Glu348Lys | c.1042G>A | 2.06e-06 | 3 / 0 | 3.69 | 0.109 | BENIGN | 0.87 | rs1044176414 |
| 170 | p.Gly170Asp | c.509G>A | 6.84e-07 | 1 / 0 | 3.65 | 0.658 | PATHOGENIC | 0.97 | |
| 232 | p.Glu232Asp | c.696A>T | 2.74e-06 | 4 / 0 | 3.43 | 0.142 | BENIGN | 0.68 | rs772178094 |
| 232 | p.Glu232Asp | c.696A>C | 1.37e-06 | 2 / 0 | 3.43 | - | nan | - | |
| 237 | p.Asp237Tyr | c.709G>T | 6.57e-06 | 1 / 0 | 3.40 | 0.609 | PATHOGENIC | 0.71 | rs1287318511 |
| 239 | p.Arg239Trp | c.715C>T | 1.37e-06 | 2 / 0 | 3.40 | 0.369 | AMBIGUOUS | 0.70 | rs1773523930 |
| 239 | p.Arg239Gln | c.716G>A | 2.74e-06 | 4 / 0 | 3.40 | - | nan | - | rs975328159 |
| 29 | p.Ser29Cys | c.86C>G | 6.84e-07 | 1 / 0 | 3.39 | 0.492 | AMBIGUOUS | 0.84 | |
| 12 | p.Glu12Gln | c.34G>C | 2.05e-06 | 3 / 0 | 3.39 | 0.091 | BENIGN | 0.55 | |
| 8 | p.Leu8Pro | c.23T>C | 6.84e-07 | 1 / 0 | 3.39 | 0.070 | BENIGN | 0.41 | rs1773106198 |
| 12 | p.Glu12Gly | c.35A>G | 8.90e-06 | 13 / 0 | 3.39 | - | nan | - | rs779233023 |
| 244 | p.His244Tyr | c.730C>T | 1.37e-06 | 2 / 0 | 3.37 | 0.170 | BENIGN | 0.69 | rs972216916 |
| 141 | p.Gly141Trp | c.421G>T | 6.85e-07 | 1 / 0 | 3.34 | 0.893 | PATHOGENIC | 0.91 | |
| 248 | p.Met248Arg | c.743T>G | 1.37e-06 | 2 / 0 | 3.19 | 0.356 | AMBIGUOUS | 0.64 | |
| 248 | p.Met248Thr | c.743T>C | 6.85e-07 | 1 / 0 | 3.19 | - | nan | - | |
| 69 | p.Glu69Lys | c.205G>A | 6.85e-07 | 1 / 0 | 3.18 | 0.945 | PATHOGENIC | 0.98 | |
| 347 | p.Leu347Pro | c.1040T>C | 6.85e-07 | 1 / 0 | 3.18 | 0.065 | BENIGN | 0.41 | |
| 292 | p.Thr292Ile | c.875C>T | 6.84e-07 | 1 / 0 | 3.16 | 0.856 | PATHOGENIC | 0.84 | |
| 42 | p.Ile42Thr | c.125T>C | 3.42e-06 | 5 / 0 | 3.15 | 0.283 | BENIGN | 0.65 | rs1464761466 |
| 42 | p.Ile42Met | c.126A>G | 6.85e-07 | 1 / 0 | 3.15 | - | nan | - | rs1773108778 |
| 66 | p.Arg66Ile | c.197G>T | 6.85e-07 | 1 / 0 | 3.09 | 0.683 | PATHOGENIC | 0.82 | |
| 246 | p.Leu246Arg | c.737T>G | 1.37e-06 | 2 / 0 | 3.09 | 0.222 | BENIGN | 0.71 | |
| 66 | p.Arg66Lys | c.197G>A | 2.06e-06 | 3 / 0 | 3.09 | - | nan | - | |
| 27 | p.Lys27Glu | c.79A>G | 6.84e-07 | 1 / 0 | 3.06 | 0.369 | AMBIGUOUS | 0.74 | |
| 27 | p.Lys27Gln | c.79A>C | 2.05e-06 | 3 / 0 | 3.06 | - | nan | - | rs916898311 |
| 27 | p.Lys27Arg | c.80A>G | 4.78e-04 | 697 / 1 | 3.06 | - | nan | - | rs149802356 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 3.41, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 143 | TRP | 148 | HIS | 0.000 | 14.771 | -14.771 | 14.771 |
| 131 | ARG | 310 | ASP | 14.082 | 0.000 | 14.082 | 14.082 |
| 61 | ARG | 311 | TYR | 13.139 | 0.000 | 13.139 | 13.139 |
| 89 | PHE | 101 | PHE | 0.000 | 12.520 | -12.520 | 12.520 |
| 187 | TRP | 272 | SER | 0.000 | 12.102 | -12.102 | 12.102 |
| 24 | PHE | 99 | TRP | 0.000 | 11.004 | -11.004 | 11.004 |
| 219 | TYR | 255 | MET | 0.000 | 10.574 | -10.574 | 10.574 |
| 111 | TRP | 174 | TYR | 0.000 | 10.358 | -10.358 | 10.358 |
| 107 | ARG | 171 | LEU | 9.673 | 0.000 | 9.673 | 9.673 |
| 61 | ARG | 335 | HIS | 0.000 | 9.314 | -9.314 | 9.314 |
| 54 | VAL | 307 | GLN | 9.048 | 0.000 | 9.048 | 9.048 |
| 103 | TRP | 173 | ASP | 8.915 | 0.000 | 8.915 | 8.915 |
| 26 | SER | 97 | HIS | 0.000 | 8.862 | -8.862 | 8.862 |
| 107 | ARG | 173 | ASP | 0.000 | 8.747 | -8.747 | 8.747 |
| 93 | SER | 98 | ARG | 0.000 | 8.493 | -8.493 | 8.493 |
| 24 | PHE | 103 | TRP | 0.000 | 8.405 | -8.405 | 8.405 |
| 171 | LEU | 199 | PHE | 0.000 | 7.682 | -7.682 | 7.682 |
| 30 | TRP | 31 | GLU | 8.005 | 0.480 | 7.525 | 7.525 |
| 131 | ARG | 247 | GLU | 0.000 | 7.418 | -7.418 | 7.418 |
| 19 | ARG | 281 | ASP | 0.000 | 7.225 | -7.225 | 7.225 |
| 110 | GLY | 174 | TYR | 0.000 | 7.131 | -7.131 | 7.131 |
| 167 | PRO | 172 | GLY | 0.000 | 7.119 | -7.119 | 7.119 |
| 111 | TRP | 168 | LEU | 9.548 | 2.631 | 6.917 | 6.917 |
| 16 | HIS | 188 | TRP | 0.000 | 6.777 | -6.777 | 6.777 |
| 175 | VAL | 184 | THR | 0.000 | 6.775 | -6.775 | 6.775 |
| 219 | TYR | 257 | ILE | 6.656 | 0.000 | 6.656 | 6.656 |
| 172 | GLY | 186 | ASP | 6.558 | 0.000 | 6.558 | 6.558 |
| 103 | TRP | 104 | ILE | 6.396 | 0.000 | 6.396 | 6.396 |
| 185 | LEU | 187 | TRP | 8.853 | 2.507 | 6.345 | 6.345 |
| 109 | TYR | 183 | CYS | 0.000 | 6.177 | -6.177 | 6.177 |
| 249 | LYS | 313 | PHE | 3.546 | 9.614 | -6.068 | 6.068 |
| 177 | GLU | 179 | PHE | 0.000 | 6.049 | -6.049 | 6.049 |
| 177 | GLU | 182 | SER | 0.000 | 6.025 | -6.025 | 6.025 |
| 33 | ASP | 94 | CYS | 0.000 | 6.020 | -6.020 | 6.020 |
| 261 | PHE | 265 | TRP | 4.539 | 10.537 | -5.997 | 5.997 |
| 310 | ASP | 334 | LEU | 0.000 | 5.886 | -5.886 | 5.886 |
| 30 | TRP | 97 | HIS | 0.000 | 5.845 | -5.845 | 5.845 |
| 88 | PRO | 109 | TYR | 5.840 | 0.000 | 5.840 | 5.840 |
| 190 | ALA | 197 | GLN | 0.544 | 6.138 | -5.594 | 5.594 |
| 131 | ARG | 251 | THR | 0.000 | 5.555 | -5.555 | 5.555 |
| 212 | THR | 261 | PHE | 5.513 | 0.000 | 5.513 | 5.513 |
| 174 | TYR | 182 | SER | 5.420 | 0.000 | 5.420 | 5.420 |
| 114 | PHE | 164 | THR | 2.214 | 7.623 | -5.409 | 5.409 |
| 187 | TRP | 199 | PHE | 5.409 | 0.000 | 5.409 | 5.409 |
| 19 | ARG | 20 | ASP | 0.000 | 5.394 | -5.394 | 5.394 |
| 230 | SER | 247 | GLU | 5.363 | 0.000 | 5.363 | 5.363 |
| 93 | SER | 99 | TRP | 0.000 | 5.135 | -5.135 | 5.135 |
| 63 | LYS | 338 | THR | 0.000 | 5.072 | -5.072 | 5.072 |
| 92 | ILE | 97 | HIS | 5.011 | 0.000 | 5.011 | 5.011 |
| 147 | LYS | 148 | HIS | 0.000 | 4.927 | -4.927 | 4.927 |
| 103 | TRP | 107 | ARG | 4.891 | 0.000 | 4.891 | 4.891 |
| 164 | THR | 174 | TYR | 0.000 | 4.846 | -4.846 | 4.846 |
| 56 | TYR | 60 | ARG | 7.978 | 3.207 | 4.772 | 4.772 |
| 304 | ILE | 309 | ILE | 4.502 | 0.000 | 4.502 | 4.502 |
| 189 | LEU | 196 | GLY | 0.000 | 4.498 | -4.498 | 4.498 |
| 204 | LEU | 272 | SER | 4.443 | 0.000 | 4.443 | 4.443 |
| 90 | THR | 109 | TYR | 0.000 | 4.442 | -4.442 | 4.442 |
| 130 | ASP | 131 | ARG | 0.000 | 4.404 | -4.404 | 4.404 |
| 28 | LEU | 286 | GLN | 4.387 | 0.000 | 4.387 | 4.387 |
| 17 | TYR | 175 | VAL | 0.000 | 4.366 | -4.366 | 4.366 |
| 178 | PRO | 179 | PHE | 4.316 | 0.000 | 4.316 | 4.316 |
| 175 | VAL | 183 | CYS | 0.000 | 4.304 | -4.304 | 4.304 |
| 166 | MET | 171 | LEU | 0.000 | 4.287 | -4.287 | 4.287 |
| 177 | GLU | 184 | THR | 0.000 | 4.248 | -4.248 | 4.248 |
| 124 | MET | 261 | PHE | 1.253 | 5.474 | -4.222 | 4.222 |
| 33 | ASP | 93 | SER | 4.206 | 0.000 | 4.206 | 4.206 |
| 131 | ARG | 219 | TYR | 4.207 | 0.007 | 4.199 | 4.199 |
| 102 | GLY | 173 | ASP | 4.084 | 0.000 | 4.084 | 4.084 |
| 30 | TRP | 34 | LEU | 0.000 | 4.046 | -4.046 | 4.046 |
| 26 | SER | 33 | ASP | 0.000 | 4.012 | -4.012 | 4.012 |
| 16 | HIS | 178 | PRO | 0.000 | 4.008 | -4.008 | 4.008 |
| 188 | TRP | 275 | SER | 0.000 | 3.992 | -3.992 | 3.992 |
| 111 | TRP | 165 | THR | 0.000 | 3.972 | -3.972 | 3.972 |
| 257 | ILE | 302 | ASN | 0.000 | 3.951 | -3.951 | 3.951 |
| 72 | THR | 306 | TYR | 0.300 | 4.194 | -3.894 | 3.894 |
| 93 | SER | 181 | THR | 0.000 | 3.840 | -3.840 | 3.840 |
| 41 | THR | 91 | ILE | 0.000 | 3.835 | -3.835 | 3.835 |
| 92 | ILE | 99 | TRP | 3.827 | 0.000 | 3.827 | 3.827 |
| 191 | GLN | 276 | ALA | 0.000 | 3.807 | -3.807 | 3.807 |
| 86 | GLY | 109 | TYR | 0.000 | 3.753 | -3.753 | 3.753 |
| 99 | TRP | 183 | CYS | 5.496 | 1.744 | 3.752 | 3.752 |
| 17 | TYR | 186 | ASP | 0.000 | 3.710 | -3.710 | 3.710 |
| 179 | PHE | 289 | VAL | 0.000 | 3.699 | -3.699 | 3.699 |
| 348 | GLU | 349 | ILE | 0.000 | 3.691 | -3.691 | 3.691 |
| 175 | VAL | 186 | ASP | 0.000 | 3.663 | -3.663 | 3.663 |
| 170 | GLY | 186 | ASP | 3.652 | 0.000 | 3.652 | 3.652 |
| 24 | PHE | 98 | ARG | 0.000 | 3.561 | -3.561 | 3.561 |
| 109 | TYR | 296 | LYS | 0.000 | 3.495 | -3.495 | 3.495 |
| 167 | PRO | 174 | TYR | 0.000 | 3.485 | -3.485 | 3.485 |
| 187 | TRP | 276 | ALA | 0.000 | 3.461 | -3.461 | 3.461 |
| 229 | SER | 232 | GLU | 0.132 | 3.566 | -3.434 | 3.434 |
| 237 | ASP | 239 | ARG | 3.396 | 0.000 | 3.396 | 3.396 |
| 29 | SER | 31 | GLU | 0.000 | 3.394 | -3.394 | 3.394 |
| 8 | LEU | 12 | GLU | 0.368 | 3.755 | -3.387 | 3.387 |
| 191 | GLN | 197 | GLN | 3.377 | 0.000 | 3.377 | 3.377 |
| 131 | ARG | 134 | LYS | 0.000 | 3.375 | -3.375 | 3.375 |
| 230 | SER | 244 | HIS | 3.368 | 0.000 | 3.368 | 3.368 |
| 131 | ARG | 306 | TYR | 3.362 | 0.000 | 3.362 | 3.362 |
| 170 | GLY | 187 | TRP | 3.345 | 0.000 | 3.345 | 3.345 |
| 134 | LYS | 141 | GLY | 0.000 | 3.337 | -3.337 | 3.337 |
| 114 | PHE | 174 | TYR | 0.000 | 3.335 | -3.335 | 3.335 |
| 90 | THR | 181 | THR | 0.000 | 3.299 | -3.299 | 3.299 |
| 174 | TYR | 184 | THR | 2.024 | 5.320 | -3.296 | 3.296 |
| 173 | ASP | 186 | ASP | 0.287 | 3.561 | -3.275 | 3.275 |
| 107 | ARG | 174 | TYR | 0.000 | 3.236 | -3.236 | 3.236 |
| 40 | LEU | 91 | ILE | 0.000 | 3.224 | -3.224 | 3.224 |
| 244 | HIS | 248 | MET | 0.000 | 3.187 | -3.187 | 3.187 |
| 24 | PHE | 102 | GLY | 0.000 | 3.182 | -3.182 | 3.182 |
| 61 | ARG | 69 | GLU | 3.429 | 0.248 | 3.181 | 3.181 |
| 347 | LEU | 348 | GLU | 0.000 | 3.178 | -3.178 | 3.178 |
| 109 | TYR | 182 | SER | 0.000 | 3.159 | -3.159 | 3.159 |
| 177 | GLU | 292 | THR | 0.000 | 3.159 | -3.159 | 3.159 |
| 38 | PHE | 42 | ILE | 3.149 | 0.000 | 3.149 | 3.149 |
| 187 | TRP | 196 | GLY | 3.093 | 0.000 | 3.093 | 3.093 |
| 66 | ARG | 246 | LEU | 0.000 | 3.091 | -3.091 | 3.091 |
| 124 | MET | 306 | TYR | 3.091 | 0.000 | 3.091 | 3.091 |
| 26 | SER | 179 | PHE | 0.000 | 3.068 | -3.068 | 3.068 |
| 85 | VAL | 109 | TYR | 3.063 | 0.000 | 3.063 | 3.063 |
| 27 | LYS | 179 | PHE | 0.000 | 3.056 | -3.056 | 3.056 |
| 311 | TYR | 315 | CYS | 2.984 | 0.000 | 2.984 | 2.984 |
| 208 | LEU | 265 | TRP | 2.970 | 0.000 | 2.970 | 2.970 |
| 184 | THR | 268 | TYR | 0.000 | 2.970 | -2.970 | 2.970 |
| 326 | LYS | 330 | GLU | 2.943 | 0.000 | 2.943 | 2.943 |
| 72 | THR | 307 | GLN | 2.935 | 0.000 | 2.935 | 2.935 |
| 179 | PHE | 182 | SER | 0.000 | 2.919 | -2.919 | 2.919 |
| 65 | LEU | 146 | ARG | 7.311 | 4.399 | 2.912 | 2.912 |
| 124 | MET | 258 | CYS | 0.000 | 2.901 | -2.901 | 2.901 |
| 99 | TRP | 181 | THR | 5.420 | 2.541 | 2.879 | 2.879 |
| 124 | MET | 302 | ASN | 2.838 | 0.000 | 2.838 | 2.838 |
| 236 | PHE | 240 | ILE | 0.000 | 2.835 | -2.835 | 2.835 |
| 99 | TRP | 180 | GLY | 0.000 | 2.829 | -2.829 | 2.829 |
| 61 | ARG | 334 | LEU | 0.000 | 2.800 | -2.800 | 2.800 |
| 225 | LYS | 229 | SER | 0.441 | 3.222 | -2.780 | 2.780 |
| 190 | ALA | 276 | ALA | 0.000 | 2.777 | -2.777 | 2.777 |
| 37 | GLY | 95 | PHE | 0.000 | 2.777 | -2.777 | 2.777 |
| 135 | ILE | 248 | MET | 0.000 | 2.773 | -2.773 | 2.773 |
| 274 | TRP | 282 | SER | 0.239 | 3.009 | -2.770 | 2.770 |
| 162 | PHE | 163 | TRP | 3.790 | 6.559 | -2.769 | 2.769 |
| 85 | VAL | 108 | TRP | 0.000 | 2.762 | -2.762 | 2.762 |
| 33 | ASP | 181 | THR | 0.000 | 2.751 | -2.751 | 2.751 |
| 226 | VAL | 247 | GLU | 2.736 | 0.000 | 2.736 | 2.736 |
| 22 | ASP | 98 | ARG | 0.000 | 2.676 | -2.676 | 2.676 |
| 197 | GLN | 276 | ALA | 2.651 | 0.000 | 2.651 | 2.651 |
| 297 | SER | 301 | TYR | 0.912 | 3.560 | -2.647 | 2.647 |
| 303 | PRO | 308 | VAL | 2.633 | 0.000 | 2.633 | 2.633 |
| 174 | TYR | 176 | PRO | 2.610 | 0.000 | 2.610 | 2.610 |
| 167 | PRO | 173 | ASP | 0.000 | 2.566 | -2.566 | 2.566 |
| 17 | TYR | 23 | PRO | 0.000 | 2.566 | -2.566 | 2.566 |
| 87 | LYS | 296 | LYS | 0.000 | 2.564 | -2.564 | 2.564 |
| 176 | PRO | 183 | CYS | 0.000 | 2.541 | -2.541 | 2.541 |
| 191 | GLN | 278 | GLY | 0.000 | 2.534 | -2.534 | 2.534 |
| 264 | ALA | 294 | LEU | 4.368 | 6.890 | -2.521 | 2.521 |
| 130 | ASP | 144 | LEU | 0.370 | 2.889 | -2.518 | 2.518 |
| 215 | ILE | 261 | PHE | 2.500 | 0.000 | 2.500 | 2.500 |
| 187 | TRP | 268 | TYR | 0.000 | 2.498 | -2.498 | 2.498 |
| 82 | ILE | 87 | LYS | 0.000 | 2.463 | -2.463 | 2.463 |
| 16 | HIS | 17 | TYR | 0.000 | 2.449 | -2.449 | 2.449 |
| 249 | LYS | 310 | ASP | 0.000 | 2.430 | -2.430 | 2.430 |
| 179 | PHE | 181 | THR | 0.000 | 2.404 | -2.404 | 2.404 |
| 28 | LEU | 33 | ASP | 0.000 | 2.399 | -2.399 | 2.399 |
| 187 | TRP | 190 | ALA | 2.350 | 0.000 | 2.350 | 2.350 |
| 106 | CYS | 176 | PRO | 0.000 | 2.343 | -2.343 | 2.343 |
| 28 | LEU | 97 | HIS | 0.000 | 2.341 | -2.341 | 2.341 |
| 24 | PHE | 180 | GLY | 0.000 | 2.329 | -2.329 | 2.329 |
| 97 | HIS | 182 | SER | 2.271 | 0.000 | 2.271 | 2.271 |
| 174 | TYR | 185 | LEU | 0.000 | 2.248 | -2.248 | 2.248 |
| 99 | TRP | 106 | CYS | 7.796 | 5.557 | 2.239 | 2.239 |
| 153 | LEU | 157 | TRP | 2.265 | 0.041 | 2.224 | 2.224 |
| 63 | LYS | 336 | THR | 0.000 | 2.207 | -2.207 | 2.207 |
| 132 | TYR | 217 | PHE | 0.000 | 2.190 | -2.190 | 2.190 |
| 44 | GLY | 87 | LYS | 0.000 | 2.168 | -2.168 | 2.168 |
| 298 | ALA | 301 | TYR | 2.162 | 0.000 | 2.162 | 2.162 |
| 172 | GLY | 184 | THR | 2.158 | 0.000 | 2.158 | 2.158 |
| 131 | ARG | 250 | LEU | 0.000 | 2.150 | -2.150 | 2.150 |
| 43 | ILE | 87 | LYS | 0.000 | 2.146 | -2.146 | 2.146 |
| 233 | VAL | 244 | HIS | 0.209 | 2.351 | -2.143 | 2.143 |
| 38 | PHE | 95 | PHE | 0.000 | 2.130 | -2.130 | 2.130 |
| 162 | PHE | 166 | MET | 0.000 | 2.128 | -2.128 | 2.128 |
| 173 | ASP | 185 | LEU | 0.000 | 2.120 | -2.120 | 2.120 |
| 168 | LEU | 174 | TYR | 0.000 | 2.113 | -2.113 | 2.113 |
| 27 | LYS | 178 | PRO | 0.000 | 2.107 | -2.107 | 2.107 |
| 89 | PHE | 99 | TRP | 0.015 | 2.106 | -2.091 | 2.091 |
| 265 | TRP | 295 | ALA | 1.960 | 4.043 | -2.082 | 2.082 |
| 94 | CYS | 181 | THR | 0.000 | 2.080 | -2.080 | 2.080 |
| 103 | TRP | 176 | PRO | 0.000 | 2.072 | -2.072 | 2.072 |
| 179 | PHE | 292 | THR | 0.000 | 2.055 | -2.055 | 2.055 |
| 166 | MET | 199 | PHE | 3.210 | 1.167 | 2.042 | 2.042 |
| 305 | ILE | 310 | ASP | 2.037 | 0.000 | 2.037 | 2.037 |
| 99 | TRP | 109 | TYR | 1.995 | 4.017 | -2.022 | 2.022 |
| 190 | ALA | 196 | GLY | 3.718 | 1.703 | 2.015 | 2.015 |
| 22 | ASP | 27 | LYS | 0.000 | 2.011 | -2.011 | 2.011 |
| 69 | GLU | 311 | TYR | 2.011 | 0.000 | 2.011 | 2.011 |
| 92 | ILE | 101 | PHE | 0.000 | 2.004 | -2.004 | 2.004 |
| 128 | SER | 219 | TYR | 3.706 | 5.699 | -1.993 | 1.993 |
| 115 | PHE | 164 | THR | 4.537 | 6.511 | -1.974 | 1.974 |
| 131 | ARG | 257 | ILE | 1.965 | 0.000 | 1.965 | 1.965 |
| 88 | PRO | 99 | TRP | 1.959 | 0.000 | 1.959 | 1.959 |
| 177 | GLU | 178 | PRO | 0.000 | 1.943 | -1.943 | 1.943 |
| 66 | ARG | 311 | TYR | 1.939 | 0.000 | 1.939 | 1.939 |
| 76 | ALA | 307 | GLN | 1.935 | 0.000 | 1.935 | 1.935 |
| 51 | ASN | 76 | ALA | 6.045 | 4.121 | 1.924 | 1.924 |
| 134 | LYS | 247 | GLU | 0.000 | 1.913 | -1.913 | 1.913 |
| 178 | PRO | 188 | TRP | 0.000 | 1.913 | -1.913 | 1.913 |
| 115 | PHE | 116 | PHE | 1.005 | 2.916 | -1.912 | 1.912 |
| 16 | HIS | 176 | PRO | 0.000 | 1.910 | -1.910 | 1.910 |
| 99 | TRP | 182 | SER | 0.576 | 2.478 | -1.902 | 1.902 |
| 50 | GLY | 303 | PRO | 2.262 | 4.163 | -1.901 | 1.901 |
| 83 | SER | 87 | LYS | 0.000 | 1.888 | -1.888 | 1.888 |
| 88 | PRO | 101 | PHE | 1.862 | 0.000 | 1.862 | 1.862 |
| 37 | GLY | 94 | CYS | 0.000 | 1.858 | -1.858 | 1.858 |
| 98 | ARG | 181 | THR | 2.590 | 0.733 | 1.857 | 1.857 |
| 262 | LEU | 266 | ILE | 2.198 | 0.347 | 1.852 | 1.852 |
| 159 | TYR | 163 | TRP | 11.201 | 9.359 | 1.841 | 1.841 |
| 182 | SER | 184 | THR | 1.834 | 0.000 | 1.834 | 1.834 |
| 85 | VAL | 113 | GLY | 1.825 | 0.000 | 1.825 | 1.825 |
| 171 | LEU | 185 | LEU | 1.822 | 0.000 | 1.822 | 1.822 |
| 167 | PRO | 199 | PHE | 0.387 | 2.204 | -1.817 | 1.817 |
| 186 | ASP | 189 | LEU | 0.000 | 1.817 | -1.817 | 1.817 |
| 41 | THR | 90 | THR | 1.815 | 0.000 | 1.815 | 1.815 |
| 349 | ILE | 350 | HIS | 1.796 | 0.000 | 1.796 | 1.796 |
| 115 | PHE | 157 | TRP | 5.727 | 3.952 | 1.774 | 1.774 |
| 208 | LEU | 269 | ALA | 2.639 | 0.867 | 1.773 | 1.773 |
| 29 | SER | 97 | HIS | 0.000 | 1.769 | -1.769 | 1.769 |
| 12 | GLU | 280 | PRO | 0.000 | 1.765 | -1.765 | 1.765 |
| 67 | PRO | 144 | LEU | 2.614 | 0.855 | 1.758 | 1.758 |
| 24 | PHE | 176 | PRO | 0.000 | 1.747 | -1.747 | 1.747 |
| 66 | ARG | 250 | LEU | 0.000 | 1.734 | -1.734 | 1.734 |
| 37 | GLY | 90 | THR | 1.733 | 0.000 | 1.733 | 1.733 |
| 276 | ALA | 277 | PHE | 0.000 | 1.719 | -1.719 | 1.719 |
| 145 | LYS | 148 | HIS | 2.455 | 0.740 | 1.715 | 1.715 |
| 191 | GLN | 280 | PRO | 0.000 | 1.713 | -1.713 | 1.713 |
| 236 | PHE | 241 | HIS | 0.000 | 1.694 | -1.694 | 1.694 |
| 190 | ALA | 200 | ILE | 0.000 | 1.691 | -1.691 | 1.691 |
| 66 | ARG | 318 | THR | 1.685 | 0.000 | 1.685 | 1.685 |
| 66 | ARG | 315 | CYS | 1.679 | 0.000 | 1.679 | 1.679 |
| 256 | LEU | 305 | ILE | 0.319 | 1.994 | -1.675 | 1.675 |
| 106 | CYS | 175 | VAL | 0.000 | 1.670 | -1.670 | 1.670 |
| 30 | TRP | 95 | PHE | 0.000 | 1.653 | -1.653 | 1.653 |
| 177 | GLU | 268 | TYR | 0.000 | 1.648 | -1.648 | 1.648 |
| 182 | SER | 296 | LYS | 0.000 | 1.648 | -1.648 | 1.648 |
| 303 | PRO | 307 | GLN | 2.072 | 0.427 | 1.645 | 1.645 |
| 301 | TYR | 305 | ILE | 1.893 | 0.251 | 1.642 | 1.642 |
| 212 | THR | 262 | LEU | 0.402 | 2.023 | -1.621 | 1.621 |
| 75 | LEU | 302 | ASN | 1.046 | 2.666 | -1.621 | 1.621 |
| 124 | MET | 257 | ILE | 0.000 | 1.616 | -1.616 | 1.616 |
| 135 | ILE | 222 | ILE | 2.017 | 0.401 | 1.616 | 1.616 |
| 233 | VAL | 236 | PHE | 0.000 | 1.611 | -1.611 | 1.611 |
| 28 | LEU | 289 | VAL | 0.000 | 1.604 | -1.604 | 1.604 |
| 184 | THR | 187 | TRP | 0.000 | 1.600 | -1.600 | 1.600 |
| 39 | TYR | 297 | SER | 1.111 | 2.709 | -1.597 | 1.597 |
| 22 | ASP | 24 | PHE | 1.014 | 2.609 | -1.595 | 1.595 |
| 199 | PHE | 203 | ILE | 4.090 | 2.497 | 1.592 | 1.592 |
| 114 | PHE | 207 | CYS | 0.000 | 1.590 | -1.590 | 1.590 |
| 110 | GLY | 171 | LEU | 1.590 | 0.000 | 1.590 | 1.590 |
| 186 | ASP | 188 | TRP | 0.000 | 1.588 | -1.588 | 1.588 |
| 11 | ASP | 19 | ARG | 2.420 | 0.849 | 1.571 | 1.571 |
| 236 | PHE | 244 | HIS | 0.000 | 1.545 | -1.545 | 1.545 |
| 188 | TRP | 280 | PRO | 1.535 | 0.000 | 1.535 | 1.535 |
| 128 | SER | 218 | SER | 2.098 | 3.608 | -1.510 | 1.510 |
| 39 | TYR | 43 | ILE | 4.216 | 2.720 | 1.496 | 1.496 |
| 135 | ILE | 225 | LYS | 0.122 | 1.616 | -1.494 | 1.494 |
| 85 | VAL | 112 | ALA | 1.962 | 0.479 | 1.483 | 1.483 |
| 111 | TRP | 164 | THR | 6.869 | 5.389 | 1.480 | 1.480 |
| 305 | ILE | 306 | TYR | 1.469 | 0.000 | 1.469 | 1.469 |
| 163 | TRP | 206 | PHE | 7.042 | 8.509 | -1.467 | 1.467 |
| 27 | LYS | 30 | TRP | 1.465 | 0.000 | 1.465 | 1.465 |
| 75 | LEU | 123 | THR | 2.196 | 0.742 | 1.453 | 1.453 |
| 226 | VAL | 248 | MET | 0.000 | 1.447 | -1.447 | 1.447 |
| 114 | PHE | 203 | ILE | 0.000 | 1.444 | -1.444 | 1.444 |
| 99 | TRP | 173 | ASP | 1.443 | 0.000 | 1.443 | 1.443 |
| 245 | VAL | 249 | LYS | 1.442 | 0.000 | 1.442 | 1.442 |
| 176 | PRO | 182 | SER | 3.268 | 1.831 | 1.437 | 1.437 |
| 186 | ASP | 200 | ILE | 0.000 | 1.424 | -1.424 | 1.424 |
| 8 | LEU | 13 | ARG | 0.000 | 1.409 | -1.409 | 1.409 |
| 26 | SER | 181 | THR | 0.000 | 1.407 | -1.407 | 1.407 |
| 89 | PHE | 109 | TYR | 2.392 | 0.997 | 1.395 | 1.395 |
| 83 | SER | 88 | PRO | 0.000 | 1.395 | -1.395 | 1.395 |
| 174 | TYR | 181 | THR | 1.391 | 0.000 | 1.391 | 1.391 |
| 167 | PRO | 185 | LEU | 0.000 | 1.382 | -1.382 | 1.382 |
| 253 | VAL | 313 | PHE | 1.374 | 0.000 | 1.374 | 1.374 |
| 37 | GLY | 93 | SER | 1.370 | 0.000 | 1.370 | 1.370 |
| 23 | PRO | 176 | PRO | 0.000 | 1.367 | -1.367 | 1.367 |
| 107 | ARG | 168 | LEU | 1.997 | 0.637 | 1.360 | 1.360 |
| 63 | LYS | 337 | VAL | 0.000 | 1.358 | -1.358 | 1.358 |
| 89 | PHE | 92 | ILE | 1.353 | 0.000 | 1.353 | 1.353 |
| 179 | PHE | 285 | ILE | 0.000 | 1.352 | -1.352 | 1.352 |
| 132 | TYR | 137 | TYR | 2.881 | 4.215 | -1.334 | 1.334 |
| 61 | ARG | 336 | THR | 0.000 | 1.333 | -1.333 | 1.333 |
| 27 | LYS | 285 | ILE | 0.000 | 1.330 | -1.330 | 1.330 |
| 61 | ARG | 65 | LEU | 0.000 | 1.318 | -1.318 | 1.318 |
| 104 | ILE | 108 | TRP | 1.306 | 0.000 | 1.306 | 1.306 |
| 78 | CYS | 116 | PHE | 3.677 | 4.982 | -1.305 | 1.305 |
| 47 | SER | 299 | ALA | 5.506 | 4.205 | 1.301 | 1.301 |
| 93 | SER | 101 | PHE | 0.000 | 1.298 | -1.298 | 1.298 |
| 137 | TYR | 140 | TYR | 1.955 | 0.658 | 1.298 | 1.298 |
| 127 | VAL | 306 | TYR | 1.294 | 0.000 | 1.294 | 1.294 |
| 121 | LEU | 207 | CYS | 2.884 | 1.593 | 1.291 | 1.291 |
| 257 | ILE | 306 | TYR | 1.834 | 3.121 | -1.287 | 1.287 |
| 26 | SER | 98 | ARG | 0.000 | 1.279 | -1.279 | 1.279 |
| 336 | THR | 338 | THR | 0.000 | 1.276 | -1.276 | 1.276 |
| 205 | PHE | 206 | PHE | 3.865 | 5.130 | -1.265 | 1.265 |
| 79 | ASP | 302 | ASN | 4.666 | 3.407 | 1.260 | 1.260 |
| 26 | SER | 28 | LEU | 0.000 | 1.258 | -1.258 | 1.258 |
| 240 | ILE | 243 | SER | 1.256 | 0.000 | 1.256 | 1.256 |
| 171 | LEU | 189 | LEU | 0.000 | 1.246 | -1.246 | 1.246 |
| 110 | GLY | 183 | CYS | 0.000 | 1.233 | -1.233 | 1.233 |
| 253 | VAL | 306 | TYR | 0.000 | 1.233 | -1.233 | 1.233 |
| 177 | GLU | 183 | CYS | 0.000 | 1.223 | -1.223 | 1.223 |
| 294 | LEU | 301 | TYR | 0.000 | 1.223 | -1.223 | 1.223 |
| 292 | THR | 296 | LYS | 0.470 | 1.691 | -1.221 | 1.221 |
| 241 | HIS | 245 | VAL | 0.396 | 1.601 | -1.204 | 1.204 |
| 28 | LEU | 179 | PHE | 0.000 | 1.199 | -1.199 | 1.199 |
| 96 | CYS | 100 | VAL | 0.000 | 1.181 | -1.181 | 1.181 |
| 222 | ILE | 251 | THR | 0.000 | 1.179 | -1.179 | 1.179 |
| 70 | ILE | 150 | TYR | 2.616 | 1.437 | 1.179 | 1.179 |
| 122 | ILE | 211 | PRO | 0.000 | 1.164 | -1.164 | 1.164 |
| 123 | THR | 156 | ILE | 1.596 | 2.754 | -1.158 | 1.158 |
| 219 | TYR | 251 | THR | 0.000 | 1.151 | -1.151 | 1.151 |
| 264 | ALA | 301 | TYR | 2.028 | 0.878 | 1.150 | 1.150 |
| 188 | TRP | 191 | GLN | 0.013 | 1.161 | -1.149 | 1.149 |
| 144 | LEU | 149 | ALA | 1.148 | 0.000 | 1.148 | 1.148 |
| 139 | SER | 140 | TYR | 0.029 | 1.176 | -1.147 | 1.147 |
| 74 | ASN | 157 | TRP | 5.784 | 4.641 | 1.143 | 1.143 |
| 106 | CYS | 173 | ASP | 1.142 | 0.000 | 1.142 | 1.142 |
| 34 | LEU | 95 | PHE | 0.000 | 1.140 | -1.140 | 1.140 |
| 91 | ILE | 101 | PHE | 1.126 | 0.000 | 1.126 | 1.126 |
| 172 | GLY | 189 | LEU | 0.000 | 1.101 | -1.101 | 1.101 |
| 163 | TRP | 202 | ASN | 0.563 | 1.661 | -1.097 | 1.097 |
| 271 | VAL | 283 | ILE | 0.193 | 1.287 | -1.094 | 1.094 |
| 51 | ASN | 303 | PRO | 4.348 | 5.438 | -1.090 | 1.090 |
| 121 | LEU | 208 | LEU | 1.378 | 0.291 | 1.087 | 1.087 |
| 253 | VAL | 309 | ILE | 2.120 | 3.202 | -1.082 | 1.082 |
| 99 | TRP | 101 | PHE | 4.306 | 3.225 | 1.081 | 1.081 |
| 66 | ARG | 335 | HIS | 0.000 | 1.072 | -1.072 | 1.072 |
| 300 | MET | 304 | ILE | 0.000 | 1.060 | -1.060 | 1.060 |
| 301 | TYR | 302 | ASN | 1.170 | 0.116 | 1.054 | 1.054 |
| 90 | THR | 182 | SER | 0.000 | 1.050 | -1.050 | 1.050 |
| 111 | TRP | 171 | LEU | 1.049 | 0.000 | 1.049 | 1.049 |
| 89 | PHE | 108 | TRP | 0.000 | 1.044 | -1.044 | 1.044 |
| 25 | ALA | 180 | GLY | 0.000 | 1.044 | -1.044 | 1.044 |
| 92 | ILE | 98 | ARG | 1.038 | 0.000 | 1.038 | 1.038 |
| 17 | TYR | 281 | ASP | 1.037 | 0.000 | 1.037 | 1.037 |
| 29 | SER | 286 | GLN | 1.037 | 0.000 | 1.037 | 1.037 |
| 260 | GLY | 301 | TYR | 3.720 | 2.686 | 1.034 | 1.034 |
| 80 | LEU | 84 | VAL | 0.001 | 1.035 | -1.034 | 1.034 |
| 106 | CYS | 183 | CYS | 6.552 | 7.573 | -1.021 | 1.021 |
| 233 | VAL | 241 | HIS | 0.000 | 1.019 | -1.019 | 1.019 |
| 219 | TYR | 254 | ALA | 3.792 | 4.805 | -1.013 | 1.013 |
| 121 | LEU | 265 | TRP | 1.006 | 0.000 | 1.006 | 1.006 |
| 226 | VAL | 251 | THR | 0.998 | 0.000 | 0.998 | 0.998 |
| 127 | VAL | 131 | ARG | 1.324 | 0.328 | 0.996 | 0.996 |
| 250 | LEU | 335 | HIS | 0.000 | 0.988 | -0.988 | 0.988 |
| 33 | ASP | 97 | HIS | 4.190 | 5.178 | -0.988 | 0.988 |
| 275 | SER | 283 | ILE | 1.742 | 2.729 | -0.986 | 0.986 |
| 43 | ILE | 300 | MET | 0.383 | 1.368 | -0.984 | 0.984 |
| 44 | GLY | 83 | SER | 1.193 | 0.210 | 0.983 | 0.983 |
| 163 | TRP | 207 | CYS | 1.968 | 2.951 | -0.983 | 0.983 |
| 171 | LEU | 186 | ASP | 0.982 | 0.000 | 0.982 | 0.982 |
| 16 | HIS | 177 | GLU | 0.000 | 0.981 | -0.981 | 0.981 |
| 201 | LEU | 276 | ALA | 0.979 | 0.000 | 0.979 | 0.979 |
| 268 | TYR | 272 | SER | 3.067 | 4.043 | -0.977 | 0.977 |
| 179 | PHE | 288 | SER | 0.000 | 0.968 | -0.968 | 0.968 |
| 300 | MET | 301 | TYR | 0.000 | 0.965 | -0.965 | 0.965 |
| 172 | GLY | 199 | PHE | 0.000 | 0.963 | -0.963 | 0.963 |
| 204 | LEU | 277 | PHE | 0.000 | 0.957 | -0.957 | 0.957 |
| 93 | SER | 100 | VAL | 0.000 | 0.954 | -0.954 | 0.954 |
| 9 | PRO | 12 | GLU | 0.000 | 0.954 | -0.954 | 0.954 |
| 99 | TRP | 105 | GLY | 3.874 | 2.926 | 0.948 | 0.948 |
| 106 | CYS | 171 | LEU | 0.947 | 0.000 | 0.947 | 0.947 |
| 136 | CYS | 222 | ILE | 0.238 | 1.181 | -0.943 | 0.943 |
| 70 | ILE | 146 | ARG | 0.544 | 1.484 | -0.940 | 0.940 |
| 89 | PHE | 110 | GLY | 0.937 | 0.000 | 0.937 | 0.937 |
| 206 | PHE | 211 | PRO | 1.997 | 2.922 | -0.925 | 0.925 |
| 133 | LEU | 141 | GLY | 0.000 | 0.921 | -0.921 | 0.921 |
| 187 | TRP | 200 | ILE | 2.321 | 1.409 | 0.912 | 0.912 |
| 216 | VAL | 262 | LEU | 0.919 | 0.007 | 0.911 | 0.911 |
| 175 | VAL | 176 | PRO | 0.107 | 1.017 | -0.910 | 0.910 |
| 185 | LEU | 203 | ILE | 0.000 | 0.906 | -0.906 | 0.906 |
| 56 | TYR | 57 | MET | 0.259 | 1.163 | -0.904 | 0.904 |
| 74 | ASN | 153 | LEU | 3.811 | 2.914 | 0.897 | 0.897 |
| 71 | MET | 153 | LEU | 0.406 | 1.297 | -0.891 | 0.891 |
| 135 | ILE | 251 | THR | 0.000 | 0.889 | -0.889 | 0.889 |
| 100 | VAL | 101 | PHE | 1.762 | 2.640 | -0.878 | 0.878 |
| 305 | ILE | 309 | ILE | 0.000 | 0.874 | -0.874 | 0.874 |
| 75 | LEU | 306 | TYR | 1.418 | 0.548 | 0.870 | 0.870 |
| 54 | VAL | 306 | TYR | 0.000 | 0.869 | -0.869 | 0.869 |
| 79 | ASP | 120 | SER | 2.990 | 2.124 | 0.866 | 0.866 |
| 54 | VAL | 76 | ALA | 0.000 | 0.863 | -0.863 | 0.863 |
| 163 | TRP | 203 | ILE | 1.076 | 1.932 | -0.856 | 0.856 |
| 121 | LEU | 211 | PRO | 1.076 | 1.930 | -0.854 | 0.854 |
| 185 | LEU | 200 | ILE | 0.000 | 0.847 | -0.847 | 0.847 |
| 106 | CYS | 172 | GLY | 0.843 | 0.000 | 0.843 | 0.843 |
| 202 | ASN | 206 | PHE | 1.079 | 1.922 | -0.843 | 0.843 |
| 174 | TYR | 186 | ASP | 0.958 | 0.115 | 0.843 | 0.843 |
| 243 | SER | 247 | GLU | 0.910 | 0.071 | 0.839 | 0.839 |
| 131 | ARG | 222 | ILE | 0.972 | 1.810 | -0.838 | 0.838 |
| 70 | ILE | 153 | LEU | 0.278 | 1.113 | -0.834 | 0.834 |
| 98 | ARG | 100 | VAL | 0.000 | 0.820 | -0.820 | 0.820 |
| 51 | ASN | 307 | GLN | 0.819 | 0.000 | 0.819 | 0.819 |
| 215 | ILE | 258 | CYS | 0.000 | 0.818 | -0.818 | 0.818 |
| 279 | ARG | 282 | SER | 0.067 | 0.880 | -0.813 | 0.813 |
| 352 | GLU | 353 | TRP | 0.813 | 0.000 | 0.813 | 0.813 |
| 199 | PHE | 200 | ILE | 0.000 | 0.812 | -0.812 | 0.812 |
| 41 | THR | 95 | PHE | 0.000 | 0.811 | -0.811 | 0.811 |
| 244 | HIS | 247 | GLU | 0.807 | 0.000 | 0.807 | 0.807 |
| 106 | CYS | 174 | TYR | 0.000 | 0.805 | -0.805 | 0.805 |
| 126 | ALA | 152 | CYS | 0.000 | 0.802 | -0.802 | 0.802 |
| 97 | HIS | 181 | THR | 0.924 | 0.123 | 0.801 | 0.801 |
| 118 | CYS | 207 | CYS | 1.056 | 0.257 | 0.799 | 0.799 |
| 246 | LEU | 337 | VAL | 0.000 | 0.795 | -0.795 | 0.795 |
| 334 | LEU | 335 | HIS | 0.792 | 0.000 | 0.792 | 0.792 |
| 268 | TYR | 292 | THR | 2.988 | 3.776 | -0.788 | 0.788 |
| 187 | TRP | 275 | SER | 0.000 | 0.784 | -0.784 | 0.784 |
| 29 | SER | 32 | ALA | 0.000 | 0.777 | -0.777 | 0.777 |
| 191 | GLN | 200 | ILE | 0.768 | 0.000 | 0.768 | 0.768 |
| 48 | THR | 83 | SER | 1.490 | 2.256 | -0.766 | 0.766 |
| 187 | TRP | 204 | LEU | 0.000 | 0.766 | -0.766 | 0.766 |
| 152 | CYS | 156 | ILE | 0.000 | 0.765 | -0.765 | 0.765 |
| 55 | LEU | 73 | ILE | 1.059 | 1.821 | -0.763 | 0.763 |
| 265 | TRP | 268 | TYR | 0.279 | 1.041 | -0.762 | 0.762 |
| 68 | ALA | 130 | ASP | 0.748 | 0.000 | 0.748 | 0.748 |
| 40 | LEU | 43 | ILE | 0.000 | 0.747 | -0.747 | 0.747 |
| 128 | SER | 258 | CYS | 0.000 | 0.733 | -0.733 | 0.733 |
| 178 | PRO | 288 | SER | 0.000 | 0.733 | -0.733 | 0.733 |
| 117 | GLY | 261 | PHE | 0.000 | 0.726 | -0.726 | 0.726 |
| 66 | ARG | 314 | ALA | 0.725 | 0.000 | 0.725 | 0.725 |
| 197 | GLN | 277 | PHE | 0.000 | 0.718 | -0.718 | 0.718 |
| 127 | VAL | 254 | ALA | 0.000 | 0.716 | -0.716 | 0.716 |
| 166 | MET | 169 | VAL | 0.000 | 0.715 | -0.715 | 0.715 |
| 208 | LEU | 268 | TYR | 0.715 | 0.000 | 0.715 | 0.715 |
| 22 | ASP | 25 | ALA | 0.424 | 1.127 | -0.703 | 0.703 |
| 66 | ARG | 69 | GLU | 8.794 | 9.495 | -0.701 | 0.701 |
| 68 | ALA | 134 | LYS | 0.701 | 0.000 | 0.701 | 0.701 |
| 223 | ILE | 254 | ALA | 0.700 | 0.000 | 0.700 | 0.700 |
| 121 | LEU | 215 | ILE | 0.166 | 0.864 | -0.698 | 0.698 |
| 223 | ILE | 227 | LYS | 0.000 | 0.694 | -0.694 | 0.694 |
| 264 | ALA | 298 | ALA | 0.191 | 0.880 | -0.689 | 0.689 |
| 262 | LEU | 267 | PRO | 0.685 | 0.003 | 0.682 | 0.682 |
| 114 | PHE | 163 | TRP | 0.000 | 0.682 | -0.682 | 0.682 |
| 284 | PRO | 286 | GLN | 0.091 | 0.773 | -0.682 | 0.682 |
| 78 | CYS | 120 | SER | 2.864 | 3.545 | -0.681 | 0.681 |
| 82 | ILE | 116 | PHE | 4.245 | 4.913 | -0.668 | 0.668 |
| 125 | THR | 211 | PRO | 3.544 | 4.211 | -0.667 | 0.667 |
| 306 | TYR | 311 | TYR | 0.666 | 0.000 | 0.666 | 0.666 |
| 75 | LEU | 257 | ILE | 0.000 | 0.664 | -0.664 | 0.664 |
| 23 | PRO | 103 | TRP | 0.000 | 0.664 | -0.664 | 0.664 |
| 302 | ASN | 306 | TYR | 1.136 | 0.473 | 0.663 | 0.663 |
| 28 | LEU | 285 | ILE | 0.000 | 0.662 | -0.662 | 0.662 |
| 132 | TYR | 221 | LYS | 2.030 | 2.691 | -0.661 | 0.661 |
| 246 | LEU | 313 | PHE | 0.660 | 0.000 | 0.660 | 0.660 |
| 189 | LEU | 197 | GLN | 0.000 | 0.660 | -0.660 | 0.660 |
| 132 | TYR | 218 | SER | 3.582 | 2.923 | 0.659 | 0.659 |
| 25 | ALA | 98 | ARG | 0.000 | 0.655 | -0.655 | 0.655 |
| 223 | ILE | 251 | THR | 0.653 | 0.000 | 0.653 | 0.653 |
| 234 | ALA | 244 | HIS | 0.647 | 0.000 | 0.647 | 0.647 |
| 273 | VAL | 277 | PHE | 1.272 | 0.626 | 0.646 | 0.646 |
| 226 | VAL | 250 | LEU | 0.644 | 0.000 | 0.644 | 0.644 |
| 302 | ASN | 307 | GLN | 0.641 | 0.000 | 0.641 | 0.641 |
| 121 | LEU | 261 | PHE | 1.823 | 2.456 | -0.634 | 0.634 |
| 219 | TYR | 306 | TYR | 0.632 | 0.000 | 0.632 | 0.632 |
| 173 | ASP | 182 | SER | 0.629 | 0.000 | 0.629 | 0.629 |
| 340 | VAL | 342 | LYS | 0.000 | 0.627 | -0.627 | 0.627 |
| 135 | ILE | 250 | LEU | 0.625 | 0.000 | 0.625 | 0.625 |
| 135 | ILE | 247 | GLU | 0.000 | 0.624 | -0.624 | 0.624 |
| 343 | SER | 344 | SER | 0.616 | 0.000 | 0.616 | 0.616 |
| 118 | CYS | 122 | ILE | 1.052 | 0.439 | 0.613 | 0.613 |
| 136 | CYS | 225 | LYS | 1.110 | 1.716 | -0.605 | 0.605 |
| 136 | CYS | 221 | LYS | 0.650 | 1.250 | -0.600 | 0.600 |
| 159 | TYR | 206 | PHE | 4.905 | 5.503 | -0.598 | 0.598 |
| 36 | ALA | 94 | CYS | 0.000 | 0.594 | -0.594 | 0.594 |
| 47 | SER | 300 | MET | 2.029 | 2.612 | -0.583 | 0.583 |
| 247 | GLU | 250 | LEU | 0.000 | 0.582 | -0.582 | 0.582 |
| 74 | ASN | 78 | CYS | 1.122 | 0.546 | 0.577 | 0.577 |
| 81 | GLY | 86 | GLY | 0.000 | 0.575 | -0.575 | 0.575 |
| 223 | ILE | 255 | MET | 0.649 | 1.224 | -0.574 | 0.574 |
| 43 | ILE | 297 | SER | 2.195 | 1.623 | 0.572 | 0.572 |
| 43 | ILE | 293 | LEU | 0.572 | 0.000 | 0.572 | 0.572 |
| 92 | ILE | 100 | VAL | 0.000 | 0.566 | -0.566 | 0.566 |
| 140 | TYR | 142 | VAL | 0.566 | 0.000 | 0.566 | 0.566 |
| 51 | ASN | 299 | ALA | 1.604 | 2.168 | -0.564 | 0.564 |
| 225 | LYS | 232 | GLU | 0.000 | 0.564 | -0.564 | 0.564 |
| 32 | ALA | 286 | GLN | 0.564 | 0.000 | 0.564 | 0.564 |
| 191 | GLN | 277 | PHE | 0.000 | 0.561 | -0.561 | 0.561 |
| 48 | THR | 80 | LEU | 1.690 | 2.251 | -0.561 | 0.561 |
| 118 | CYS | 159 | TYR | 0.159 | 0.719 | -0.560 | 0.560 |
| 178 | PRO | 285 | ILE | 0.000 | 0.560 | -0.560 | 0.560 |
| 114 | PHE | 185 | LEU | 0.596 | 0.037 | 0.559 | 0.559 |
| 120 | SER | 302 | ASN | 0.557 | 0.000 | 0.557 | 0.557 |
| 253 | VAL | 305 | ILE | 0.000 | 0.556 | -0.556 | 0.556 |
| 23 | PRO | 180 | GLY | 0.000 | 0.553 | -0.553 | 0.553 |
| 201 | LEU | 277 | PHE | 2.691 | 2.139 | 0.552 | 0.552 |
| 47 | SER | 79 | ASP | 1.088 | 0.538 | 0.550 | 0.550 |
| 82 | ILE | 117 | GLY | 1.852 | 1.303 | 0.549 | 0.549 |
| 204 | LEU | 273 | VAL | 1.805 | 1.260 | 0.545 | 0.545 |
| 191 | GLN | 275 | SER | 2.367 | 2.908 | -0.541 | 0.541 |
| 55 | LEU | 77 | VAL | 0.641 | 1.181 | -0.540 | 0.540 |
| 133 | LEU | 137 | TYR | 0.548 | 0.011 | 0.537 | 0.537 |
| 85 | VAL | 89 | PHE | 0.535 | 0.000 | 0.535 | 0.535 |
| 170 | GLY | 185 | LEU | 0.531 | 0.000 | 0.531 | 0.531 |
| 54 | VAL | 72 | THR | 0.000 | 0.531 | -0.531 | 0.531 |
| 249 | LYS | 309 | ILE | 0.000 | 0.523 | -0.523 | 0.523 |
| 233 | VAL | 240 | ILE | 0.523 | 0.000 | 0.523 | 0.523 |
| 251 | THR | 255 | MET | 0.516 | 0.000 | 0.516 | 0.516 |
| 228 | SER | 229 | SER | 0.290 | 0.802 | -0.513 | 0.513 |
| 133 | LEU | 144 | LEU | 0.000 | 0.512 | -0.512 | 0.512 |
| 91 | ILE | 100 | VAL | 0.508 | 0.000 | 0.508 | 0.508 |
| 37 | GLY | 91 | ILE | 0.000 | 0.506 | -0.506 | 0.506 |
| 187 | TRP | 188 | TRP | 0.000 | 0.505 | -0.505 | 0.505 |
| 114 | PHE | 118 | CYS | 0.000 | 0.501 | -0.501 | 0.501 |
| 59 | SER | 60 | ARG | 0.060 | 0.561 | -0.501 | 0.501 |
| 24 | PHE | 106 | CYS | 0.000 | 0.493 | -0.493 | 0.493 |
| 55 | LEU | 76 | ALA | 0.954 | 1.444 | -0.489 | 0.489 |
| 36 | ALA | 293 | LEU | 1.255 | 0.768 | 0.487 | 0.487 |
| 51 | ASN | 80 | LEU | 0.916 | 0.432 | 0.485 | 0.485 |
| 271 | VAL | 288 | SER | 1.009 | 0.529 | 0.480 | 0.480 |
| 65 | LEU | 70 | ILE | 0.565 | 1.042 | -0.477 | 0.477 |
| 81 | GLY | 116 | PHE | 6.110 | 6.586 | -0.476 | 0.476 |
| 217 | PHE | 221 | LYS | 4.002 | 3.527 | 0.475 | 0.475 |
| 205 | PHE | 210 | LEU | 3.184 | 3.655 | -0.472 | 0.472 |
| 22 | ASP | 23 | PRO | 1.501 | 1.972 | -0.470 | 0.470 |
| 261 | PHE | 301 | TYR | 0.463 | 0.000 | 0.463 | 0.463 |
| 69 | GLU | 335 | HIS | 0.000 | 0.462 | -0.462 | 0.462 |
| 257 | ILE | 305 | ILE | 1.939 | 2.399 | -0.461 | 0.461 |
| 347 | LEU | 349 | ILE | 0.460 | 0.000 | 0.460 | 0.460 |
| 74 | ASN | 123 | THR | 3.138 | 2.680 | 0.458 | 0.458 |
| 36 | ALA | 289 | VAL | 0.455 | 0.000 | 0.455 | 0.455 |
| 128 | SER | 306 | TYR | 0.455 | 0.000 | 0.455 | 0.455 |
| 82 | ILE | 120 | SER | 0.453 | 0.000 | 0.453 | 0.453 |
| 107 | ARG | 172 | GLY | 0.452 | 0.000 | 0.452 | 0.452 |
| 40 | LEU | 296 | LYS | 1.249 | 0.797 | 0.452 | 0.452 |
| 283 | ILE | 287 | LEU | 1.019 | 0.570 | 0.449 | 0.449 |
| 75 | LEU | 124 | MET | 1.254 | 0.806 | 0.448 | 0.448 |
| 265 | TRP | 298 | ALA | 0.878 | 1.326 | -0.448 | 0.448 |
| 85 | VAL | 116 | PHE | 0.812 | 0.365 | 0.446 | 0.446 |
| 79 | ASP | 82 | ILE | 0.466 | 0.021 | 0.445 | 0.445 |
| 39 | TYR | 40 | LEU | 0.000 | 0.440 | -0.440 | 0.440 |
| 165 | THR | 166 | MET | 0.438 | 0.000 | 0.438 | 0.438 |
| 77 | VAL | 157 | TRP | 0.302 | 0.739 | -0.437 | 0.437 |
| 175 | VAL | 181 | THR | 0.433 | 0.000 | 0.433 | 0.433 |
| 28 | LEU | 32 | ALA | 0.000 | 0.430 | -0.430 | 0.430 |
| 87 | LYS | 91 | ILE | 0.000 | 0.428 | -0.428 | 0.428 |
| 308 | VAL | 312 | LYS | 0.000 | 0.425 | -0.425 | 0.425 |
| 304 | ILE | 308 | VAL | 0.000 | 0.423 | -0.423 | 0.423 |
| 40 | LEU | 94 | CYS | 0.000 | 0.416 | -0.416 | 0.416 |
| 48 | THR | 84 | VAL | 0.000 | 0.415 | -0.415 | 0.415 |
| 98 | ARG | 180 | GLY | 0.000 | 0.413 | -0.413 | 0.413 |
| 145 | LYS | 147 | LYS | 0.000 | 0.413 | -0.413 | 0.413 |
| 261 | PHE | 298 | ALA | 0.000 | 0.409 | -0.409 | 0.409 |
| 12 | GLU | 19 | ARG | 0.408 | 0.000 | 0.408 | 0.408 |
| 47 | SER | 51 | ASN | 1.707 | 1.300 | 0.407 | 0.407 |
| 118 | CYS | 164 | THR | 0.000 | 0.402 | -0.402 | 0.402 |
| 67 | PRO | 145 | LYS | 0.245 | 0.638 | -0.393 | 0.393 |
| 25 | ALA | 97 | HIS | 0.000 | 0.392 | -0.392 | 0.392 |
| 271 | VAL | 287 | LEU | 1.120 | 0.729 | 0.391 | 0.391 |
| 111 | TRP | 115 | PHE | 3.112 | 2.724 | 0.387 | 0.387 |
| 25 | ALA | 179 | PHE | 0.000 | 0.386 | -0.386 | 0.386 |
| 17 | TYR | 103 | TRP | 0.000 | 0.384 | -0.384 | 0.384 |
| 3 | LEU | 5 | HIS | 0.000 | 0.384 | -0.384 | 0.384 |
| 95 | PHE | 98 | ARG | 0.384 | 0.000 | 0.384 | 0.384 |
| 92 | ILE | 96 | CYS | 0.000 | 0.382 | -0.382 | 0.382 |
| 189 | LEU | 199 | PHE | 0.000 | 0.381 | -0.381 | 0.381 |
| 51 | ASN | 79 | ASP | 4.078 | 4.458 | -0.379 | 0.379 |
| 120 | SER | 261 | PHE | 0.000 | 0.379 | -0.379 | 0.379 |
| 119 | GLY | 156 | ILE | 0.684 | 1.063 | -0.379 | 0.379 |
| 90 | THR | 99 | TRP | 0.000 | 0.377 | -0.377 | 0.377 |
| 115 | PHE | 160 | ALA | 3.507 | 3.135 | 0.372 | 0.372 |
| 112 | ALA | 116 | PHE | 0.499 | 0.128 | 0.371 | 0.371 |
| 122 | ILE | 156 | ILE | 1.667 | 2.037 | -0.371 | 0.371 |
| 294 | LEU | 297 | SER | 0.000 | 0.370 | -0.370 | 0.370 |
| 250 | LEU | 317 | GLN | 0.366 | 0.000 | 0.366 | 0.366 |
| 68 | ALA | 250 | LEU | 0.000 | 0.365 | -0.365 | 0.365 |
| 53 | TYR | 54 | VAL | 0.355 | 0.000 | 0.355 | 0.355 |
| 58 | SER | 73 | ILE | 2.412 | 2.766 | -0.354 | 0.354 |
| 10 | GLN | 13 | ARG | 0.000 | 0.345 | -0.345 | 0.345 |
| 237 | ASP | 238 | SER | 0.340 | 0.000 | 0.340 | 0.340 |
| 164 | THR | 165 | THR | 0.000 | 0.339 | -0.339 | 0.339 |
| 15 | PRO | 188 | TRP | 0.000 | 0.332 | -0.332 | 0.332 |
| 190 | ALA | 277 | PHE | 0.000 | 0.331 | -0.331 | 0.331 |
| 252 | LYS | 256 | LEU | 0.000 | 0.330 | -0.330 | 0.330 |
| 79 | ASP | 299 | ALA | 5.709 | 5.381 | 0.328 | 0.328 |
| 204 | LEU | 209 | LEU | 3.977 | 4.303 | -0.326 | 0.326 |
| 132 | TYR | 222 | ILE | 2.771 | 3.097 | -0.326 | 0.326 |
| 256 | LEU | 309 | ILE | 0.547 | 0.872 | -0.325 | 0.325 |
| 215 | ILE | 262 | LEU | 0.000 | 0.320 | -0.320 | 0.320 |
| 120 | SER | 124 | MET | 0.212 | 0.531 | -0.319 | 0.319 |
| 136 | CYS | 137 | TYR | 1.038 | 1.353 | -0.315 | 0.315 |
| 65 | LEU | 73 | ILE | 1.404 | 1.089 | 0.315 | 0.315 |
| 134 | LYS | 144 | LEU | 0.000 | 0.313 | -0.313 | 0.313 |
| 266 | ILE | 270 | VAL | 0.505 | 0.194 | 0.311 | 0.311 |
| 27 | LYS | 180 | GLY | 0.000 | 0.311 | -0.311 | 0.311 |
| 159 | TYR | 207 | CYS | 0.058 | 0.367 | -0.309 | 0.309 |
| 337 | VAL | 339 | THR | 0.309 | 0.000 | 0.309 | 0.309 |
| 50 | GLY | 307 | GLN | 0.308 | 0.000 | 0.308 | 0.308 |
| 252 | LYS | 255 | MET | 0.306 | 0.000 | 0.306 | 0.306 |
| 153 | LEU | 156 | ILE | 0.000 | 0.306 | -0.306 | 0.306 |
| 16 | HIS | 20 | ASP | 0.000 | 0.306 | -0.306 | 0.306 |
| 39 | TYR | 293 | LEU | 3.902 | 4.206 | -0.304 | 0.304 |
| 146 | ARG | 150 | TYR | 2.466 | 2.769 | -0.303 | 0.303 |
| 78 | CYS | 157 | TRP | 1.170 | 0.870 | 0.300 | 0.300 |
| 83 | SER | 299 | ALA | 0.000 | 0.300 | -0.300 | 0.300 |
| 284 | PRO | 287 | LEU | 0.480 | 0.780 | -0.299 | 0.299 |
| 71 | MET | 127 | VAL | 1.148 | 1.447 | -0.298 | 0.298 |
| 166 | MET | 172 | GLY | 0.000 | 0.295 | -0.295 | 0.295 |
| 309 | ILE | 313 | PHE | 1.044 | 1.338 | -0.294 | 0.294 |
| 173 | ASP | 184 | THR | 0.000 | 0.294 | -0.294 | 0.294 |
| 40 | LEU | 93 | SER | 0.290 | 0.000 | 0.290 | 0.290 |
| 67 | PRO | 149 | ALA | 1.338 | 1.049 | 0.289 | 0.289 |
| 144 | LEU | 148 | HIS | 0.734 | 0.446 | 0.288 | 0.288 |
| 340 | VAL | 341 | ARG | 0.288 | 0.000 | 0.288 | 0.288 |
| 107 | ARG | 169 | VAL | 0.283 | 0.000 | 0.283 | 0.283 |
| 89 | PHE | 296 | LYS | 0.283 | 0.000 | 0.283 | 0.283 |
| 167 | PRO | 203 | ILE | 0.281 | 0.000 | 0.281 | 0.281 |
| 40 | LEU | 89 | PHE | 0.279 | 0.000 | 0.279 | 0.279 |
| 14 | LEU | 18 | LEU | 0.978 | 0.700 | 0.278 | 0.278 |
| 283 | ILE | 284 | PRO | 0.896 | 0.622 | 0.274 | 0.274 |
| 68 | ALA | 131 | ARG | 0.000 | 0.263 | -0.263 | 0.263 |
| 124 | MET | 215 | ILE | 1.286 | 1.549 | -0.263 | 0.263 |
| 103 | TRP | 175 | VAL | 0.000 | 0.262 | -0.262 | 0.262 |
| 78 | CYS | 119 | GLY | 1.934 | 1.674 | 0.260 | 0.260 |
| 273 | VAL | 278 | GLY | 0.000 | 0.260 | -0.260 | 0.260 |
| 283 | ILE | 288 | SER | 0.000 | 0.259 | -0.259 | 0.259 |
| 42 | ILE | 46 | LEU | 0.929 | 0.671 | 0.258 | 0.258 |
| 285 | ILE | 289 | VAL | 0.000 | 0.256 | -0.256 | 0.256 |
| 106 | CYS | 184 | THR | 0.255 | 0.000 | 0.255 | 0.255 |
| 264 | ALA | 265 | TRP | 0.473 | 0.220 | 0.253 | 0.253 |
| 288 | SER | 289 | VAL | 0.176 | 0.426 | -0.250 | 0.250 |
| 205 | PHE | 209 | LEU | 0.244 | 0.000 | 0.244 | 0.244 |
| 182 | SER | 292 | THR | 0.000 | 0.244 | -0.244 | 0.244 |
| 129 | LEU | 218 | SER | 1.734 | 1.977 | -0.243 | 0.243 |
| 185 | LEU | 199 | PHE | 0.000 | 0.242 | -0.242 | 0.242 |
| 74 | ASN | 156 | ILE | 0.250 | 0.491 | -0.241 | 0.241 |
| 23 | PRO | 24 | PHE | 0.058 | 0.297 | -0.239 | 0.239 |
| 197 | GLN | 201 | LEU | 0.000 | 0.239 | -0.239 | 0.239 |
| 39 | TYR | 294 | LEU | 0.000 | 0.236 | -0.236 | 0.236 |
| 54 | VAL | 58 | SER | 0.400 | 0.164 | 0.236 | 0.236 |
| 96 | CYS | 98 | ARG | 0.000 | 0.231 | -0.231 | 0.231 |
| 173 | ASP | 175 | VAL | 0.000 | 0.228 | -0.228 | 0.228 |
| 125 | THR | 129 | LEU | 0.226 | 0.000 | 0.226 | 0.226 |
| 121 | LEU | 125 | THR | 0.000 | 0.226 | -0.226 | 0.226 |
| 209 | LEU | 269 | ALA | 0.224 | 0.000 | 0.224 | 0.224 |
| 263 | ILE | 294 | LEU | 0.348 | 0.569 | -0.221 | 0.221 |
| 129 | LEU | 214 | VAL | 1.865 | 2.085 | -0.221 | 0.221 |
| 290 | VAL | 294 | LEU | 0.220 | 0.000 | 0.220 | 0.220 |
| 267 | PRO | 291 | PRO | 3.064 | 3.284 | -0.220 | 0.220 |
| 92 | ILE | 183 | CYS | 0.219 | 0.000 | 0.219 | 0.219 |
| 33 | ASP | 96 | CYS | 0.219 | 0.000 | 0.219 | 0.219 |
| 71 | MET | 152 | CYS | 1.187 | 1.404 | -0.218 | 0.218 |
| 163 | TRP | 199 | PHE | 0.216 | 0.000 | 0.216 | 0.216 |
| 135 | ILE | 226 | VAL | 0.154 | 0.368 | -0.214 | 0.214 |
| 40 | LEU | 87 | LYS | 0.000 | 0.214 | -0.214 | 0.214 |
| 110 | GLY | 184 | THR | 0.000 | 0.211 | -0.211 | 0.211 |
| 306 | TYR | 307 | GLN | 0.206 | 0.000 | 0.206 | 0.206 |
| 40 | LEU | 293 | LEU | 1.827 | 1.624 | 0.204 | 0.204 |
| 208 | LEU | 212 | THR | 0.268 | 0.472 | -0.204 | 0.204 |
| 47 | SER | 87 | LYS | 0.000 | 0.202 | -0.202 | 0.202 |
| 321 | LEU | 324 | THR | 0.202 | 0.000 | 0.202 | 0.202 |
| 128 | SER | 222 | ILE | 0.068 | 0.266 | -0.198 | 0.198 |
| 114 | PHE | 167 | PRO | 0.198 | 0.000 | 0.198 | 0.198 |
| 271 | VAL | 275 | SER | 0.000 | 0.197 | -0.197 | 0.197 |
| 165 | THR | 169 | VAL | 0.000 | 0.197 | -0.197 | 0.197 |
| 333 | ARG | 336 | THR | 0.000 | 0.197 | -0.197 | 0.197 |
| 87 | LYS | 88 | PRO | 0.949 | 0.753 | 0.196 | 0.196 |
| 67 | PRO | 146 | ARG | 0.371 | 0.567 | -0.196 | 0.196 |
| 65 | LEU | 69 | GLU | 1.478 | 1.674 | -0.196 | 0.196 |
| 191 | GLN | 279 | ARG | 0.000 | 0.191 | -0.191 | 0.191 |
| 266 | ILE | 267 | PRO | 1.151 | 1.342 | -0.191 | 0.191 |
| 64 | LYS | 146 | ARG | 6.453 | 6.643 | -0.190 | 0.190 |
| 271 | VAL | 291 | PRO | 0.870 | 0.681 | 0.189 | 0.189 |
| 175 | VAL | 185 | LEU | 0.000 | 0.187 | -0.187 | 0.187 |
| 245 | VAL | 248 | MET | 0.186 | 0.000 | 0.186 | 0.186 |
| 66 | ARG | 247 | GLU | 0.000 | 0.186 | -0.186 | 0.186 |
| 229 | SER | 247 | GLU | 0.181 | 0.000 | 0.181 | 0.181 |
| 82 | ILE | 299 | ALA | 0.181 | 0.000 | 0.181 | 0.181 |
| 131 | ARG | 254 | ALA | 0.000 | 0.179 | -0.179 | 0.179 |
| 219 | TYR | 258 | CYS | 2.579 | 2.402 | 0.177 | 0.177 |
| 58 | SER | 65 | LEU | 0.000 | 0.176 | -0.176 | 0.176 |
| 16 | HIS | 281 | ASP | 0.000 | 0.175 | -0.175 | 0.175 |
| 126 | ALA | 156 | ILE | 0.451 | 0.275 | 0.175 | 0.175 |
| 70 | ILE | 149 | ALA | 0.309 | 0.484 | -0.175 | 0.175 |
| 132 | TYR | 133 | LEU | 0.325 | 0.150 | 0.175 | 0.175 |
| 78 | CYS | 123 | THR | 0.174 | 0.000 | 0.174 | 0.174 |
| 97 | HIS | 183 | CYS | 0.172 | 0.000 | 0.172 | 0.172 |
| 135 | ILE | 136 | CYS | 0.033 | 0.206 | -0.172 | 0.172 |
| 323 | ALA | 324 | THR | 0.000 | 0.172 | -0.172 | 0.172 |
| 132 | TYR | 136 | CYS | 2.853 | 2.687 | 0.165 | 0.165 |
| 206 | PHE | 210 | LEU | 0.267 | 0.432 | -0.164 | 0.164 |
| 335 | HIS | 337 | VAL | 0.164 | 0.000 | 0.164 | 0.164 |
| 25 | ALA | 27 | LYS | 0.000 | 0.162 | -0.162 | 0.162 |
| 171 | LEU | 184 | THR | 0.161 | 0.000 | 0.161 | 0.161 |
| 194 | VAL | 198 | VAL | 0.243 | 0.083 | 0.160 | 0.160 |
| 125 | THR | 215 | ILE | 3.832 | 3.673 | 0.160 | 0.160 |
| 274 | TRP | 283 | ILE | 5.404 | 5.563 | -0.158 | 0.158 |
| 101 | PHE | 106 | CYS | 0.000 | 0.157 | -0.157 | 0.157 |
| 184 | THR | 185 | LEU | 0.000 | 0.155 | -0.155 | 0.155 |
| 114 | PHE | 268 | TYR | 0.154 | 0.000 | 0.154 | 0.154 |
| 249 | LYS | 335 | HIS | 0.000 | 0.152 | -0.152 | 0.152 |
| 200 | ILE | 204 | LEU | 0.793 | 0.641 | 0.152 | 0.152 |
| 246 | LEU | 317 | GLN | 0.149 | 0.000 | 0.149 | 0.149 |
| 66 | ARG | 67 | PRO | 0.949 | 0.801 | 0.148 | 0.148 |
| 235 | HIS | 236 | PHE | 0.146 | 0.000 | 0.146 | 0.146 |
| 17 | TYR | 18 | LEU | 2.552 | 2.407 | 0.145 | 0.145 |
| 150 | TYR | 153 | LEU | 0.139 | 0.281 | -0.141 | 0.141 |
| 285 | ILE | 286 | GLN | 0.000 | 0.141 | -0.141 | 0.141 |
| 190 | ALA | 193 | SER | 0.137 | 0.000 | 0.137 | 0.137 |
| 52 | GLY | 80 | LEU | 0.000 | 0.135 | -0.135 | 0.135 |
| 116 | PHE | 157 | TRP | 1.574 | 1.439 | 0.135 | 0.135 |
| 267 | PRO | 294 | LEU | 0.454 | 0.589 | -0.135 | 0.135 |
| 71 | MET | 123 | THR | 1.567 | 1.700 | -0.133 | 0.133 |
| 172 | GLY | 182 | SER | 0.132 | 0.000 | 0.132 | 0.132 |
| 122 | ILE | 160 | ALA | 0.131 | 0.000 | 0.131 | 0.131 |
| 173 | ASP | 174 | TYR | 0.000 | 0.131 | -0.131 | 0.131 |
| 36 | ALA | 93 | SER | 0.131 | 0.000 | 0.131 | 0.131 |
| 280 | PRO | 281 | ASP | 0.320 | 0.192 | 0.129 | 0.129 |
| 202 | ASN | 207 | CYS | 0.082 | 0.210 | -0.128 | 0.128 |
| 55 | LEU | 80 | LEU | 0.481 | 0.608 | -0.127 | 0.127 |
| 122 | ILE | 159 | TYR | 2.826 | 2.951 | -0.126 | 0.126 |
| 174 | TYR | 180 | GLY | 0.126 | 0.000 | 0.126 | 0.126 |
| 203 | ILE | 207 | CYS | 0.460 | 0.334 | 0.126 | 0.126 |
| 51 | ASN | 302 | ASN | 0.000 | 0.124 | -0.124 | 0.124 |
| 238 | SER | 239 | ARG | 0.122 | 0.000 | 0.122 | 0.122 |
| 346 | VAL | 347 | LEU | 1.827 | 1.949 | -0.122 | 0.122 |
| 285 | ILE | 288 | SER | 0.030 | 0.151 | -0.121 | 0.121 |
| 131 | ARG | 253 | VAL | 0.121 | 0.000 | 0.121 | 0.121 |
| 268 | TYR | 291 | PRO | 3.780 | 3.661 | 0.119 | 0.119 |
| 345 | ALA | 346 | VAL | 0.336 | 0.219 | 0.117 | 0.117 |
| 167 | PRO | 171 | LEU | 0.117 | 0.000 | 0.117 | 0.117 |
| 200 | ILE | 272 | SER | 0.116 | 0.000 | 0.116 | 0.116 |
| 289 | VAL | 293 | LEU | 0.771 | 0.886 | -0.115 | 0.115 |
| 143 | TRP | 144 | LEU | 0.000 | 0.115 | -0.115 | 0.115 |
| 90 | THR | 94 | CYS | 0.134 | 0.248 | -0.114 | 0.114 |
| 261 | PHE | 266 | ILE | 0.114 | 0.000 | 0.114 | 0.114 |
| 298 | ALA | 302 | ASN | 0.111 | 0.000 | 0.111 | 0.111 |
| 82 | ILE | 113 | GLY | 0.000 | 0.109 | -0.109 | 0.109 |
| 215 | ILE | 219 | TYR | 0.986 | 1.094 | -0.108 | 0.108 |
| 268 | TYR | 295 | ALA | 0.983 | 0.879 | 0.104 | 0.104 |
| 217 | PHE | 218 | SER | 0.000 | 0.103 | -0.103 | 0.103 |
| 41 | THR | 45 | ILE | 0.588 | 0.486 | 0.102 | 0.102 |
| 175 | VAL | 182 | SER | 0.000 | 0.101 | -0.101 | 0.101 |
| 253 | VAL | 257 | ILE | 0.644 | 0.544 | 0.101 | 0.101 |
| 105 | GLY | 110 | GLY | 0.101 | 0.000 | 0.101 | 0.101 |
| 175 | VAL | 177 | GLU | 0.100 | 0.000 | 0.100 | 0.100 |
| 133 | LEU | 138 | LEU | 0.476 | 0.574 | -0.098 | 0.098 |
| 80 | LEU | 85 | VAL | 0.000 | 0.097 | -0.097 | 0.097 |
| 79 | ASP | 298 | ALA | 0.096 | 0.000 | 0.096 | 0.096 |
| 103 | TRP | 174 | TYR | 0.000 | 0.095 | -0.095 | 0.095 |
| 94 | CYS | 95 | PHE | 0.095 | 0.000 | 0.095 | 0.095 |
| 67 | PRO | 134 | LYS | 0.000 | 0.095 | -0.095 | 0.095 |
| 133 | LEU | 140 | TYR | 0.000 | 0.094 | -0.094 | 0.094 |
| 111 | TRP | 112 | ALA | 0.569 | 0.477 | 0.092 | 0.092 |
| 14 | LEU | 15 | PRO | 0.678 | 0.770 | -0.092 | 0.092 |
| 282 | SER | 283 | ILE | 0.373 | 0.282 | 0.091 | 0.091 |
| 125 | THR | 214 | VAL | 1.385 | 1.476 | -0.090 | 0.090 |
| 46 | LEU | 300 | MET | 2.444 | 2.534 | -0.090 | 0.090 |
| 200 | ILE | 277 | PHE | 0.000 | 0.089 | -0.089 | 0.089 |
| 187 | TRP | 203 | ILE | 0.000 | 0.087 | -0.087 | 0.087 |
| 115 | PHE | 161 | SER | 4.518 | 4.432 | 0.085 | 0.085 |
| 8 | LEU | 9 | PRO | 1.179 | 1.094 | 0.085 | 0.085 |
| 205 | PHE | 211 | PRO | 0.370 | 0.454 | -0.085 | 0.085 |
| 279 | ARG | 280 | PRO | 0.686 | 0.602 | 0.084 | 0.084 |
| 108 | TRP | 112 | ALA | 0.000 | 0.082 | -0.082 | 0.082 |
| 249 | LYS | 253 | VAL | 0.000 | 0.078 | -0.078 | 0.078 |
| 290 | VAL | 291 | PRO | 1.198 | 1.274 | -0.076 | 0.076 |
| 306 | TYR | 334 | LEU | 0.000 | 0.076 | -0.076 | 0.076 |
| 91 | ILE | 95 | PHE | 1.457 | 1.382 | 0.075 | 0.075 |
| 74 | ASN | 119 | GLY | 0.043 | 0.117 | -0.075 | 0.075 |
| 101 | PHE | 109 | TYR | 0.075 | 0.000 | 0.075 | 0.075 |
| 71 | MET | 156 | ILE | 0.452 | 0.381 | 0.072 | 0.072 |
| 108 | TRP | 111 | TRP | 1.657 | 1.728 | -0.071 | 0.071 |
| 264 | ALA | 295 | ALA | 3.637 | 3.567 | 0.071 | 0.071 |
| 198 | VAL | 202 | ASN | 0.825 | 0.756 | 0.068 | 0.068 |
| 30 | TRP | 96 | CYS | 0.000 | 0.068 | -0.068 | 0.068 |
| 302 | ASN | 303 | PRO | 0.882 | 0.949 | -0.068 | 0.068 |
| 128 | SER | 215 | ILE | 2.580 | 2.645 | -0.065 | 0.065 |
| 240 | ILE | 242 | SER | 0.064 | 0.000 | 0.064 | 0.064 |
| 64 | LYS | 69 | GLU | 0.125 | 0.061 | 0.064 | 0.064 |
| 47 | SER | 52 | GLY | 0.187 | 0.123 | 0.064 | 0.064 |
| 84 | VAL | 85 | VAL | 0.000 | 0.063 | -0.063 | 0.063 |
| 43 | ILE | 48 | THR | 0.062 | 0.000 | 0.062 | 0.062 |
| 119 | GLY | 160 | ALA | 0.847 | 0.791 | 0.057 | 0.057 |
| 75 | LEU | 120 | SER | 3.018 | 3.074 | -0.057 | 0.057 |
| 26 | SER | 180 | GLY | 0.000 | 0.056 | -0.056 | 0.056 |
| 166 | MET | 167 | PRO | 0.877 | 0.822 | 0.055 | 0.055 |
| 47 | SER | 303 | PRO | 0.000 | 0.054 | -0.054 | 0.054 |
| 45 | ILE | 49 | PHE | 1.278 | 1.332 | -0.054 | 0.054 |
| 189 | LEU | 200 | ILE | 0.000 | 0.054 | -0.054 | 0.054 |
| 261 | PHE | 262 | LEU | 0.079 | 0.132 | -0.053 | 0.053 |
| 15 | PRO | 18 | LEU | 0.626 | 0.573 | 0.053 | 0.053 |
| 225 | LYS | 228 | SER | 0.481 | 0.429 | 0.052 | 0.052 |
| 259 | ALA | 263 | ILE | 0.083 | 0.033 | 0.050 | 0.050 |
| 130 | ASP | 134 | LYS | 7.018 | 6.968 | 0.050 | 0.050 |
| 71 | MET | 149 | ALA | 2.051 | 2.003 | 0.049 | 0.049 |
| 53 | TYR | 57 | MET | 5.767 | 5.815 | -0.049 | 0.049 |
| 219 | TYR | 222 | ILE | 0.975 | 1.023 | -0.048 | 0.048 |
| 328 | SER | 329 | LEU | 0.048 | 0.000 | 0.048 | 0.048 |
| 77 | VAL | 116 | PHE | 0.112 | 0.064 | 0.048 | 0.048 |
| 75 | LEU | 79 | ASP | 1.663 | 1.711 | -0.048 | 0.048 |
| 237 | ASP | 240 | ILE | 0.265 | 0.218 | 0.047 | 0.047 |
| 212 | THR | 216 | VAL | 0.179 | 0.225 | -0.045 | 0.045 |
| 264 | ALA | 291 | PRO | 0.349 | 0.304 | 0.045 | 0.045 |
| 121 | LEU | 212 | THR | 0.000 | 0.045 | -0.045 | 0.045 |
| 216 | VAL | 220 | VAL | 0.375 | 0.330 | 0.045 | 0.045 |
| 72 | THR | 127 | VAL | 0.044 | 0.000 | 0.044 | 0.044 |
| 325 | LYS | 329 | LEU | 0.043 | 0.000 | 0.043 | 0.043 |
| 40 | LEU | 90 | THR | 1.676 | 1.719 | -0.043 | 0.043 |
| 165 | THR | 168 | LEU | 0.000 | 0.040 | -0.040 | 0.040 |
| 204 | LEU | 208 | LEU | 0.323 | 0.284 | 0.039 | 0.039 |
| 274 | TRP | 287 | LEU | 0.000 | 0.037 | -0.037 | 0.037 |
| 222 | ILE | 226 | VAL | 0.231 | 0.195 | 0.036 | 0.036 |
| 43 | ILE | 296 | LYS | 1.249 | 1.285 | -0.036 | 0.036 |
| 26 | SER | 27 | LYS | 0.033 | 0.000 | 0.033 | 0.033 |
| 214 | VAL | 218 | SER | 0.335 | 0.305 | 0.030 | 0.030 |
| 15 | PRO | 17 | TYR | 5.328 | 5.299 | 0.029 | 0.029 |
| 203 | ILE | 208 | LEU | 0.556 | 0.586 | -0.029 | 0.029 |
| 118 | CYS | 160 | ALA | 1.350 | 1.379 | -0.028 | 0.028 |
| 11 | ASP | 14 | LEU | 0.000 | 0.028 | -0.028 | 0.028 |
| 210 | LEU | 211 | PRO | 1.319 | 1.291 | 0.027 | 0.027 |
| 45 | ILE | 50 | GLY | 0.000 | 0.025 | -0.025 | 0.025 |
| 106 | CYS | 111 | TRP | 0.025 | 0.000 | 0.025 | 0.025 |
| 246 | LEU | 250 | LEU | 0.000 | 0.025 | -0.025 | 0.025 |
| 47 | SER | 83 | SER | 3.167 | 3.191 | -0.024 | 0.024 |
| 51 | ASN | 75 | LEU | 0.023 | 0.000 | 0.023 | 0.023 |
| 56 | TYR | 59 | SER | 0.077 | 0.099 | -0.022 | 0.022 |
| 160 | ALA | 165 | THR | 0.000 | 0.021 | -0.021 | 0.021 |
| 61 | ARG | 66 | ARG | 0.019 | 0.000 | 0.019 | 0.019 |
| 29 | SER | 30 | TRP | 0.018 | 0.000 | 0.018 | 0.018 |
| 210 | LEU | 214 | VAL | 0.157 | 0.173 | -0.017 | 0.017 |
| 246 | LEU | 335 | HIS | 0.000 | 0.017 | -0.017 | 0.017 |
| 117 | GLY | 265 | TRP | 0.062 | 0.078 | -0.016 | 0.016 |
| 78 | CYS | 79 | ASP | 0.016 | 0.000 | 0.016 | 0.016 |
| 302 | ASN | 305 | ILE | 0.000 | 0.015 | -0.015 | 0.015 |
| 129 | LEU | 132 | TYR | 0.000 | 0.015 | -0.015 | 0.015 |
| 134 | LYS | 135 | ILE | 0.000 | 0.014 | -0.014 | 0.014 |
| 79 | ASP | 303 | PRO | 0.012 | 0.000 | 0.012 | 0.012 |
| 17 | TYR | 176 | PRO | 0.000 | 0.012 | -0.012 | 0.012 |
| 53 | TYR | 56 | TYR | 0.000 | 0.011 | -0.011 | 0.011 |
| 34 | LEU | 93 | SER | 0.010 | 0.000 | 0.010 | 0.010 |
| 71 | MET | 126 | ALA | 0.010 | 0.000 | 0.010 | 0.010 |
| 73 | ILE | 77 | VAL | 0.113 | 0.122 | -0.009 | 0.009 |
| 206 | PHE | 207 | CYS | 0.000 | 0.009 | -0.009 | 0.009 |
| 89 | PHE | 105 | GLY | 0.000 | 0.007 | -0.007 | 0.007 |
| 200 | ILE | 276 | ALA | 0.418 | 0.413 | 0.005 | 0.005 |
| 88 | PRO | 89 | PHE | 0.000 | 0.003 | -0.003 | 0.003 |
| 17 | TYR | 188 | TRP | 0.002 | 0.000 | 0.002 | 0.002 |
| 34 | LEU | 38 | PHE | 0.000 | 0.001 | -0.001 | 0.001 |
| 148 | HIS | 151 | ILE | 0.000 | 0.001 | -0.001 | 0.001 |
| 103 | TRP | 106 | CYS | 0.000 | 0.001 | -0.001 | 0.001 |
| 123 | THR | 127 | VAL | 0.100 | 0.101 | -0.000 | 0.000 |
RRCS change distribution
-0.42
Mean ΔRRCS
2.40
Std Dev
-0.18
Median
Magnitude classification
49
High (|Δ| ≥ 5.0)
42
Medium (3.4 ≤ |Δ| < 5.0)
756
Low (|Δ| < 3.4)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 3.41, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar