OPRK
811
Total Contact Pairs
87
Significant Changes
12.52
Max Increase
-9.41
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | GLN6 | ARG202 | 12.524 | 0.000 | +12.524 | HIGH |
| 2 | ARG202 | ASP204 | 10.555 | 0.970 | +9.585 | HIGH |
| 3 | TYR119 (2.64x64) | TYR313 (7.36x35) | 12.520 | 3.063 | +9.457 | HIGH |
| 4 | ASP266 (6.27x27) | ARG270 (6.31x31) | 1.495 | 10.910 | -9.414 | HIGH |
| 5 | TYR140 (3.34x34) | TRP183 (4.50x50) | 10.748 | 2.177 | +8.571 | HIGH |
| 6 | MET90 (12.50x50) | ASN95 (2.40x40) | 0.035 | 8.113 | -8.078 | HIGH |
| 7 | ALA331 (7.54x54) | PHE337 (8.50x50) | 8.084 | 0.090 | +7.994 | HIGH |
| 8 | TRP33 | ILE54 | 0.000 | 7.847 | -7.847 | HIGH |
| 9 | PHE30 | GLN115 (2.60x60) | 0.000 | 6.923 | -6.923 | HIGH |
| 10 | ARG267 (6.28x28) | ARG271 (6.32x32) | 0.000 | 6.869 | -6.869 | HIGH |
| 11 | TYR246 (5.58x58) | LEU277 (6.38x38) | 0.000 | 6.866 | -6.866 | HIGH |
| 12 | TYR87 (1.60x60) | PHE344 (8.57x57) | 6.861 | 0.000 | +6.861 | HIGH |
| 13 | ARG371 | ASP372 | 6.717 | 0.000 | +6.717 | HIGH |
| 14 | TRP33 | ASN122 (2.67x67) | 0.000 | 6.613 | -6.613 | HIGH |
| 15 | PHE8 | VAL207 | 6.506 | 0.000 | +6.506 | HIGH |
| 16 | TYR66 (1.39x39) | TYR313 (7.36x35) | 6.451 | 0.000 | +6.451 | HIGH |
| 17 | PHE8 | ARG202 | 6.448 | 0.000 | +6.448 | HIGH |
| 18 | PRO31 | TYR313 (7.36x35) | 0.000 | 5.786 | -5.786 | HIGH |
| 19 | TYR140 (3.34x34) | SER186 (4.53x53) | 8.438 | 2.654 | +5.784 | HIGH |
| 20 | LEU370 | ARG371 | 5.780 | 0.000 | +5.780 | HIGH |
| 21 | LEU258 | LYS265 (6.26x26) | 5.672 | 0.000 | +5.672 | HIGH |
| 22 | LEU107 (2.52x52) | ASN141 (3.35x35) | 5.595 | 0.000 | +5.595 | HIGH |
| 23 | GLU264 (6.25x25) | ARG267 (6.28x28) | 5.524 | 0.000 | +5.524 | HIGH |
| 24 | ASP372 | ILE373 | 5.222 | 0.000 | +5.222 | HIGH |
| 25 | ARG156 (3.50x50) | ARG170 (34.57x57) | 0.000 | 5.203 | -5.203 | HIGH |
| 26 | PHE293 (6.54x54) | TYR312 (7.35x34) | 5.083 | 10.283 | -5.200 | HIGH |
| 27 | GLN6 | HIS304 | 5.106 | 0.000 | +5.106 | HIGH |
| 28 | PHE114 (2.59x59) | PHE126 (23.52x52) | 1.820 | 6.751 | -4.931 | MED |
| 29 | PHE8 | GLU209 | 4.880 | 0.000 | +4.880 | MED |
| 30 | ASP155 (3.49x49) | ARG156 (3.50x50) | 0.000 | 4.789 | -4.789 | MED |
| 31 | TYR140 (3.34x34) | SER187 (4.54x54) | 4.183 | 8.909 | -4.726 | MED |
| 32 | TYR66 (1.39x39) | MET112 (2.57x57) | 7.830 | 3.108 | +4.721 | MED |
| 33 | ILE146 (3.40x40) | PHE283 (6.44x44) | 0.680 | 5.387 | -4.707 | MED |
| 34 | SER27 | TYR219 (5.31x32) | 0.000 | 4.642 | -4.642 | MED |
| 35 | ARG156 (3.50x50) | ILE272 (6.33x33) | 0.000 | 4.631 | -4.631 | MED |
| 36 | THR88 (12.48x48) | ASN95 (2.40x40) | 4.597 | 0.000 | +4.597 | MED |
| 37 | LEU259 | LYS265 (6.26x26) | 4.555 | 0.000 | +4.555 | MED |
| 38 | MET81 (1.54x54) | PHE99 (2.44x44) | 2.184 | 6.468 | -4.284 | MED |
| 39 | ALA331 (7.54x54) | LYS338 (8.51x51) | 0.000 | 4.258 | -4.258 | MED |
| 40 | PRO327 (7.50x50) | PHE332 (7.55x55) | 4.214 | 0.000 | +4.214 | MED |
| 41 | SER26 | GLU297 (6.58x58) | 0.000 | 4.201 | -4.201 | MED |
| 42 | ARG156 (3.50x50) | TYR246 (5.58x58) | 4.180 | 0.000 | +4.180 | MED |
| 43 | ASP105 (2.50x50) | ASN141 (3.35x35) | 0.000 | 4.135 | -4.135 | MED |
| 44 | ARG271 (6.32x32) | GLU335 (8.48x48) | 4.636 | 0.574 | +4.062 | MED |
| 45 | PHE231 (5.43x44) | LEU295 (6.56x56) | 4.043 | 0.000 | +4.043 | MED |
| 46 | TYR66 (1.39x39) | TYR119 (2.64x64) | 0.000 | 3.948 | -3.948 | MED |
| 47 | THR111 (2.56x56) | ASP138 (3.32x32) | 5.306 | 1.359 | +3.947 | MED |
| 48 | PHE332 (7.55x55) | LYS338 (8.51x51) | 3.921 | 0.000 | +3.921 | MED |
| 49 | LEU309 (7.32x31) | TYR313 (7.36x35) | 1.981 | 5.812 | -3.831 | MED |
| 50 | ASP334 (8.47x47) | PHE337 (8.50x50) | 0.502 | 4.098 | -3.596 | MED |
| 51 | PHE30 | VAL118 (2.63x63) | 0.000 | 3.579 | -3.579 | MED |
| 52 | TYR66 (1.39x39) | TYR320 (7.43x42) | 0.000 | 3.519 | -3.519 | MED |
| 53 | LEU149 (3.43x43) | TYR330 (7.53x53) | 3.476 | 0.000 | +3.476 | MED |
| 54 | ILE328 (7.51x51) | LEU333 (7.56x56) | 3.472 | 0.000 | +3.472 | MED |
| 55 | TYR97 (2.42x42) | MET151 (3.45x45) | 0.316 | 3.753 | -3.436 | MED |
| 56 | MET376 | ASN377 | 5.952 | 2.530 | +3.421 | MED |
| 57 | LEU333 (7.56x56) | LYS338 (8.51x51) | 3.393 | 0.000 | +3.393 | MED |
| 58 | ARG9 | HIS304 | 3.352 | 0.000 | +3.352 | MED |
| 59 | PHE283 (6.44x44) | TRP287 (6.48x48) | 4.488 | 7.830 | -3.342 | MED |
| 60 | GLU11 | PRO12 | 0.477 | 3.770 | -3.292 | MED |
| 61 | PRO31 | TYR312 (7.35x34) | 0.000 | 3.163 | -3.163 | MED |
| 62 | ALA331 (7.54x54) | PHE341 (8.54x54) | 0.000 | 3.154 | -3.154 | MED |
| 63 | PRO59 (1.32x32) | TYR119 (2.64x64) | 5.135 | 2.031 | +3.104 | MED |
| 64 | ARG252 (5.64x64) | SER255 (5.67x67) | 3.084 | 0.000 | +3.084 | MED |
| 65 | VAL108 (2.53x53) | TYR320 (7.43x42) | 3.809 | 0.734 | +3.075 | MED |
| 66 | THR111 (2.56x56) | TYR320 (7.43x42) | 3.073 | 0.000 | +3.073 | MED |
| 67 | ASN25 | TYR219 (5.31x32) | 0.000 | 3.071 | -3.071 | MED |
| 68 | ILE54 | THR306 (7.29x28) | 3.950 | 0.906 | +3.044 | MED |
| 69 | THR94 | ASP155 (3.49x49) | 0.000 | 2.978 | -2.978 | MED |
| 70 | ILE62 | SER310 | 2.966 | 0.000 | +2.966 | MED |
| 71 | MET249 | THR273 | 0.000 | 2.961 | -2.961 | MED |
| 72 | THR94 | ARG156 (3.50x50) | 0.000 | 2.932 | -2.932 | MED |
| 73 | TYR140 (3.34x34) | ASN141 (3.35x35) | 2.910 | 0.000 | +2.910 | MED |
| 74 | TYR246 (5.58x58) | VAL276 | 3.255 | 6.134 | -2.878 | MED |
| 75 | TYR119 (2.64x64) | SER310 | 2.877 | 0.000 | +2.877 | MED |
| 76 | ARG156 (3.50x50) | TYR330 (7.53x53) | 2.852 | 0.000 | +2.852 | MED |
| 77 | VAL108 (2.53x53) | ASN141 (3.35x35) | 3.318 | 6.138 | -2.819 | MED |
| 78 | VAL296 | SER301 | 6.636 | 3.842 | +2.795 | MED |
| 79 | VAL83 | PHE337 (8.50x50) | 3.865 | 1.075 | +2.790 | MED |
| 80 | PHE8 | VAL205 | 2.775 | 0.000 | +2.775 | MED |
| 81 | TYR369 | LEU370 | 2.730 | 0.000 | +2.730 | MED |
| 82 | SER27 | LEU212 | 0.000 | 2.692 | -2.692 | MED |
| 83 | TRP33 | TYR313 (7.36x35) | 0.000 | 2.672 | -2.672 | MED |
| 84 | ASP105 (2.50x50) | ASN326 | 5.583 | 2.914 | +2.669 | MED |
| 85 | SER27 | SER211 | 0.000 | 2.662 | -2.662 | MED |
| 86 | PHE30 | CYS210 | 0.000 | 2.639 | -2.639 | MED |
| 87 | SER26 | LYS227 | 0.000 | 2.592 | -2.592 | MED |
| 88 | VAL118 (2.63x63) | TYR313 (7.36x35) | 2.555 | 0.000 | +2.555 | LOW |
| 89 | ILE96 | ASN179 | 1.140 | 3.672 | -2.531 | LOW |
| 90 | PHE147 | LEU185 | 1.900 | 4.381 | -2.482 | LOW |
| 91 | ILE84 | LYS89 | 2.480 | 0.000 | +2.480 | LOW |
| 92 | LEU79 | PHE341 (8.54x54) | 1.168 | 3.617 | -2.449 | LOW |
| 93 | ARG9 | THR306 (7.29x28) | 2.434 | 0.000 | +2.434 | LOW |
| 94 | LEU253 | LEU259 | 2.423 | 0.000 | +2.423 | LOW |
| 95 | VAL279 | TYR330 (7.53x53) | 2.496 | 0.098 | +2.398 | LOW |
| 96 | ASP204 | VAL205 | 2.561 | 0.174 | +2.387 | LOW |
| 97 | ASN100 | THR148 | 0.164 | 2.542 | -2.378 | LOW |
| 98 | ILE7 | GLU209 | 2.373 | 0.000 | +2.373 | LOW |
| 99 | TYR157 | CYS245 | 4.622 | 2.254 | +2.367 | LOW |
| 100 | LEU275 | TYR330 (7.53x53) | 0.000 | 2.356 | -2.356 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.56 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 59-87 | 87 (6.9), 66 (6.5), 59 (3.1) | 3 | 81 (-4.3) | 1 |
| TM2 | 95-122 | 119 (9.5), 107 (5.6), 112 (4.7), 111 (3.9), 108 (3.1) | 5 | 95 (-8.1), 115 (-6.9), 122 (-6.6), 114 (-4.9), 99 (-4.3), 105 (-4.1), 118 (-3.6), 97 (-3.4) | 8 |
| TM3 | 138-156 | 140 (8.6), 141 (5.6), 138 (3.9), 149 (3.5) | 4 | 156 (-5.2), 155 (-4.8), 146 (-4.7), 151 (-3.4) | 4 |
| TM4 | 183-187 | 183 (8.6), 186 (5.8) | 2 | 187 (-4.7) | 1 |
| TM5 | 219-255 | 231 (4.0), 252 (3.1), 255 (3.1) | 3 | 246 (-6.9), 219 (-4.6) | 2 |
| TM6 | 264-297 | 265 (5.7), 264 (5.5), 295 (4.0) | 3 | 266 (-9.4), 270 (-9.4), 267 (-6.9), 271 (-6.9), 277 (-6.9), 293 (-5.2), 283 (-4.7), 272 (-4.6), 297 (-4.2), 287 (-3.3) | 10 |
| TM7 | 306-333 | 313 (9.5), 331 (8.0), 327 (4.2), 332 (4.2), 330 (3.5), 328 (3.5), 333 (3.5), 306 (3.0) | 8 | 312 (-5.2), 309 (-3.8), 320 (-3.5) | 3 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 88-90 | 88 (4.6) | 1 | 90 (-8.1) | 1 |
| ICL2 | 170-170 | - | 0 | 170 (-5.2) | 1 |
| ICL3 | 258-259 | 258 (5.7), 259 (4.6) | 2 | - | 0 |
| ECL1 | 126-126 | - | 0 | 126 (-4.9) | 1 |
| ECL2 | 202-209 | 202 (12.5), 204 (9.6), 207 (6.5), 209 (4.9) | 4 | - | 0 |
| ECL3 | 304-304 | 304 (5.1) | 1 | - | 0 |
| H8 | 334-344 | 337 (8.0), 344 (6.9), 335 (4.1) | 3 | 338 (-4.3), 334 (-3.6), 341 (-3.2) | 3 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
122 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 6 | p.Gln6His | c.18G>C | 7.08e-07 | 1 / 0 | 12.52 | 0.126 | BENIGN | 0.62 | |
| 6 | p.Gln6Arg | c.17A>G | 1.84e-05 | 26 / 0 | 12.52 | - | nan | - | rs1368538821 |
| 204 | p.Asp204Gly | c.611A>G | 7.19e-07 | 1 / 0 | 9.59 | 0.078 | BENIGN | 0.28 | |
| 204 | p.Asp204His | c.610G>C | 6.87e-06 | 10 / 0 | 9.59 | - | nan | - | rs200377155 |
| 313 | p.Tyr313Phe | c.938A>T | 6.84e-07 | 1 / 0 | 9.46 | 0.177 | BENIGN | 0.70 | |
| 119 | p.Tyr119Phe | c.356A>T | 2.05e-06 | 3 / 0 | 9.46 | 0.167 | BENIGN | 0.95 | rs148980561 |
| 313 | p.Tyr313Asp | c.937T>G | 1.37e-06 | 2 / 0 | 9.46 | - | nan | - | rs1806798924 |
| 266 | p.Asp266Gly | c.797A>G | 6.84e-07 | 1 / 0 | 9.41 | 0.938 | PATHOGENIC | 1.00 | |
| 270 | p.Arg270His | c.809G>A | 1.16e-05 | 17 / 0 | 9.41 | 0.433 | AMBIGUOUS | 1.00 | rs749949592 |
| 270 | p.Arg270Pro | c.809G>C | 2.74e-06 | 4 / 0 | 9.41 | - | nan | - | rs749949592 |
| 270 | p.Arg270Cys | c.808C>T | 7.52e-06 | 11 / 0 | 9.41 | - | nan | - | rs141228759 |
| 266 | p.Asp266His | c.796G>C | 6.84e-07 | 1 / 0 | 9.41 | - | nan | - | |
| 331 | p.Ala331Thr | c.991G>A | 1.71e-05 | 25 / 0 | 7.99 | 0.824 | PATHOGENIC | 0.89 | rs200397918 |
| 331 | p.Ala331Ser | c.991G>T | 6.84e-07 | 1 / 0 | 7.99 | - | nan | - | rs200397918 |
| 33 | p.Trp33Cys | c.99G>T | 6.86e-07 | 1 / 0 | 7.85 | 0.531 | AMBIGUOUS | 0.36 | rs549074768 |
| 54 | p.Ile54Asn | c.161T>A | 8.90e-06 | 13 / 0 | 7.85 | 0.386 | AMBIGUOUS | 0.53 | rs776043300 |
| 54 | p.Ile54Val | c.160A>G | 2.74e-06 | 4 / 0 | 7.85 | - | nan | - | rs367824593 |
| 33 | p.Trp33Cys | c.99G>C | 6.86e-07 | 1 / 0 | 7.85 | - | nan | - | rs549074768 |
| 30 | p.Phe30Leu | c.90T>A | 2.74e-06 | 4 / 0 | 6.92 | 0.301 | BENIGN | 0.32 | rs1433348238 |
| 30 | p.Phe30Ile | c.88T>A | 6.86e-07 | 1 / 0 | 6.92 | - | nan | - | |
| 30 | p.Phe30Leu | c.88T>C | 6.57e-06 | 1 / 0 | 6.92 | - | nan | - | rs1807373656 |
| 271 | p.Arg271Met | c.812G>T | 6.84e-07 | 1 / 0 | 6.87 | 0.986 | PATHOGENIC | 1.00 | |
| 267 | p.Arg267His | c.800G>A | 6.16e-06 | 9 / 0 | 6.87 | 0.339 | BENIGN | 0.97 | rs200420778 |
| 267 | p.Arg267Leu | c.800G>T | 1.37e-06 | 2 / 0 | 6.87 | - | nan | - | rs200420778 |
| 267 | p.Arg267Cys | c.799C>T | 7.52e-06 | 11 / 0 | 6.87 | - | nan | - | rs762806781 |
| 267 | p.Arg267Ser | c.799C>A | 1.37e-06 | 2 / 0 | 6.87 | - | nan | - | |
| 277 | p.Leu277Pro | c.830T>C | 2.74e-06 | 4 / 0 | 6.87 | 0.992 | PATHOGENIC | 0.93 | rs1243582370 |
| 246 | p.Tyr246Cys | c.737A>G | 2.74e-06 | 4 / 0 | 6.87 | 0.965 | PATHOGENIC | 1.00 | |
| 277 | p.Leu277Val | c.829C>G | 6.84e-07 | 1 / 0 | 6.87 | - | nan | - | |
| 344 | p.Phe344Ile | c.1030T>A | 6.84e-07 | 1 / 0 | 6.86 | 0.489 | AMBIGUOUS | 1.00 | rs1585626392 |
| 371 | p.Arg371Ser | c.1113G>C | 6.84e-07 | 1 / 0 | 6.72 | 0.160 | BENIGN | 0.61 | |
| 372 | p.Asp372Glu | c.1116C>A | 2.05e-06 | 3 / 0 | 6.72 | 0.072 | BENIGN | 0.53 | |
| 372 | p.Asp372Gly | c.1115A>G | 6.84e-07 | 1 / 0 | 6.72 | - | nan | - | |
| 372 | p.Asp372Tyr | c.1114G>T | 6.84e-07 | 1 / 0 | 6.72 | - | nan | - | |
| 372 | p.Asp372His | c.1114G>C | 4.79e-06 | 7 / 0 | 6.72 | - | nan | - | rs202028631 |
| 371 | p.Arg371Lys | c.1112G>A | 4.79e-06 | 7 / 0 | 6.72 | - | nan | - | rs1806793418 |
| 122 | p.Asn122Ser | c.365A>G | 4.10e-06 | 6 / 0 | 6.61 | 0.119 | BENIGN | 0.57 | rs201447402 |
| 8 | p.Phe8Leu | c.24C>G | 1.41e-06 | 2 / 0 | 6.51 | 0.765 | PATHOGENIC | 0.81 | |
| 207 | p.Val207Phe | c.619G>T | 7.13e-07 | 1 / 0 | 6.51 | 0.171 | BENIGN | 0.48 | |
| 8 | p.Phe8Leu | c.24C>A | 7.06e-07 | 1 / 0 | 6.51 | - | nan | - | |
| 8 | p.Phe8Cys | c.23T>G | 1.31e-05 | 2 / 0 | 6.51 | - | nan | - | rs908236938 |
| 66 | p.Tyr66Ser | c.197A>C | 6.85e-07 | 1 / 0 | 6.45 | 0.952 | PATHOGENIC | 1.00 | |
| 66 | p.Tyr66Cys | c.197A>G | 6.85e-07 | 1 / 0 | 6.45 | - | nan | - | |
| 66 | p.Tyr66His | c.196T>C | 6.84e-07 | 1 / 0 | 6.45 | - | nan | - | |
| 31 | p.Pro31Leu | c.92C>T | 2.13e-05 | 31 / 0 | 5.79 | 0.103 | BENIGN | 0.53 | rs201985699 |
| 31 | p.Pro31Ala | c.91C>G | 6.86e-07 | 1 / 0 | 5.79 | - | nan | - | rs941657997 |
| 31 | p.Pro31Ser | c.91C>T | 1.37e-06 | 2 / 0 | 5.79 | - | nan | - | rs941657997 |
| 186 | p.Ser186Leu | c.557C>T | 8.89e-05 | 128 / 1 | 5.78 | 0.980 | PATHOGENIC | 0.98 | rs143457105 |
| 186 | p.Ser186Thr | c.556T>A | 6.84e-07 | 1 / 0 | 5.78 | - | nan | - | |
| 370 | p.Leu370Val | c.1108C>G | 6.57e-06 | 1 / 0 | 5.78 | 0.055 | BENIGN | 0.45 | rs1806793499 |
| 258 | p.Leu258Phe | c.772C>T | 6.84e-07 | 1 / 0 | 5.67 | 0.464 | AMBIGUOUS | 0.79 | |
| 107 | p.Leu107Phe | c.321A>T | 6.84e-07 | 1 / 0 | 5.59 | 0.722 | PATHOGENIC | 0.99 | |
| 141 | p.Asn141Ser | c.422A>G | 6.84e-07 | 1 / 0 | 5.59 | 0.659 | PATHOGENIC | 1.00 | |
| 264 | p.Glu264Gly | c.791A>G | 6.84e-07 | 1 / 0 | 5.52 | 0.697 | PATHOGENIC | 0.97 | rs1563326030 |
| 373 | p.Ile373Met | c.1119C>G | 7.53e-06 | 11 / 0 | 5.22 | 0.060 | BENIGN | 0.65 | rs150426309 |
| 373 | p.Ile373Asn | c.1118T>A | 6.84e-07 | 1 / 0 | 5.22 | - | nan | - | |
| 373 | p.Ile373Phe | c.1117A>T | 6.84e-07 | 1 / 0 | 5.22 | - | nan | - | |
| 373 | p.Ile373Val | c.1117A>G | 3.42e-06 | 5 / 0 | 5.22 | - | nan | - | rs1411845698 |
| 156 | p.Arg156His | c.467G>A | 1.03e-05 | 15 / 0 | 5.20 | 0.994 | PATHOGENIC | 1.00 | rs766490405 |
| 170 | p.Arg170Leu | c.509G>T | 6.84e-07 | 1 / 0 | 5.20 | 0.994 | PATHOGENIC | 0.99 | rs894364145 |
| 170 | p.Arg170His | c.509G>A | 1.98e-05 | 29 / 0 | 5.20 | - | nan | - | rs894364145 |
| 170 | p.Arg170Cys | c.508C>T | 3.56e-05 | 52 / 0 | 5.20 | - | nan | - | rs201421010 |
| 156 | p.Arg156Cys | c.466C>T | 9.44e-05 | 138 / 0 | 5.20 | - | nan | - | rs201247710 |
| 293 | p.Phe293Leu | c.879C>A | 6.84e-07 | 1 / 0 | 5.20 | 0.984 | PATHOGENIC | 0.90 | |
| 293 | p.Phe293Cys | c.878T>G | 6.84e-07 | 1 / 0 | 5.20 | - | nan | - | |
| 293 | p.Phe293Leu | c.877T>C | 4.10e-06 | 6 / 0 | 5.20 | - | nan | - | rs764375986 |
| 304 | p.His304Arg | c.911A>G | 4.10e-06 | 6 / 0 | 5.11 | 0.070 | BENIGN | 0.53 | rs1806799823 |
| 304 | p.His304Tyr | c.910C>T | 4.79e-06 | 7 / 0 | 5.11 | - | nan | - | |
| 126 | p.Phe126Leu | c.378T>G | 2.74e-06 | 4 / 0 | 4.93 | 0.997 | PATHOGENIC | 1.00 | rs1385730017 |
| 126 | p.Phe126Ser | c.377T>C | 6.84e-06 | 10 / 0 | 4.93 | - | nan | - | rs773135770 |
| 155 | p.Asp155Asn | c.463G>A | 2.05e-06 | 3 / 0 | 4.79 | 0.997 | PATHOGENIC | 1.00 | |
| 112 | p.Met112Thr | c.335T>C | 6.84e-07 | 1 / 0 | 4.72 | 0.992 | PATHOGENIC | 0.74 | rs753996474 |
| 112 | p.Met112Val | c.334A>G | 3.42e-06 | 5 / 0 | 4.72 | - | nan | - | rs199939072 |
| 283 | p.Phe283Leu | c.847T>C | 2.05e-06 | 3 / 0 | 4.71 | 1.000 | PATHOGENIC | 1.00 | |
| 27 | p.Ser27Arg | c.81C>G | 1.17e-05 | 17 / 0 | 4.64 | 0.240 | BENIGN | 0.53 | rs766014784 |
| 219 | p.Tyr219Asp | c.655T>G | 6.89e-07 | 1 / 0 | 4.64 | 0.214 | BENIGN | 0.60 | |
| 27 | p.Ser27Asn | c.80G>A | 6.86e-07 | 1 / 0 | 4.64 | - | nan | - | |
| 27 | p.Ser27Gly | c.79A>G | 6.86e-07 | 1 / 0 | 4.64 | - | nan | - | |
| 272 | p.Ile272Leu | c.814A>C | 6.84e-07 | 1 / 0 | 4.63 | 0.878 | PATHOGENIC | 1.00 | rs1329044572 |
| 259 | p.Leu259Pro | c.776T>C | 6.57e-06 | 1 / 0 | 4.55 | 0.924 | PATHOGENIC | 0.97 | rs1806804946 |
| 99 | p.Phe99Leu | c.295T>C | 6.84e-07 | 1 / 0 | 4.28 | 0.967 | PATHOGENIC | 0.97 | |
| 81 | p.Met81Ile | c.243G>A | 2.06e-06 | 3 / 0 | 4.28 | 0.964 | PATHOGENIC | 0.97 | rs1036100225 |
| 81 | p.Met81Thr | c.242T>C | 3.43e-06 | 5 / 0 | 4.28 | - | nan | - | |
| 81 | p.Met81Leu | c.241A>C | 8.23e-06 | 12 / 0 | 4.28 | - | nan | - | rs1395767420 |
| 81 | p.Met81Val | c.241A>G | 6.86e-07 | 1 / 0 | 4.28 | - | nan | - | |
| 327 | p.Pro327Arg | c.980C>G | 1.37e-06 | 2 / 0 | 4.21 | 0.999 | PATHOGENIC | 1.00 | |
| 105 | p.Asp105Glu | c.315T>A | 6.84e-07 | 1 / 0 | 4.14 | 1.000 | PATHOGENIC | 1.00 | |
| 105 | p.Asp105Asn | c.313G>A | 6.84e-07 | 1 / 0 | 4.14 | - | nan | - | rs758708034 |
| 231 | p.Phe231Leu | c.691T>C | 9.58e-06 | 14 / 0 | 4.04 | 0.983 | PATHOGENIC | 1.00 | rs956739608 |
| 111 | p.Thr111Ile | c.332C>T | 6.84e-07 | 1 / 0 | 3.95 | 0.981 | PATHOGENIC | 0.98 | rs1452068387 |
| 111 | p.Thr111Ala | c.331A>G | 6.84e-07 | 1 / 0 | 3.95 | - | nan | - | |
| 309 | p.Leu309Pro | c.926T>C | 6.84e-07 | 1 / 0 | 3.83 | 0.861 | PATHOGENIC | 0.53 | |
| 118 | p.Val118Phe | c.352G>T | 6.84e-07 | 1 / 0 | 3.58 | 0.398 | AMBIGUOUS | 0.46 | |
| 320 | p.Tyr320Cys | c.959A>G | 4.10e-06 | 6 / 0 | 3.52 | 0.986 | PATHOGENIC | 1.00 | rs1422323074 |
| 330 | p.Tyr330Cys | c.989A>G | 4.10e-06 | 6 / 0 | 3.48 | 0.993 | PATHOGENIC | 1.00 | rs1471140960 |
| 333 | p.Leu333Pro | c.998T>C | 3.42e-06 | 5 / 0 | 3.47 | 0.996 | PATHOGENIC | 0.98 | rs756773551 |
| 328 | p.Ile328Thr | c.983T>C | 6.84e-07 | 1 / 0 | 3.47 | 0.959 | PATHOGENIC | 0.77 | |
| 377 | p.Asn377Ser | c.1130A>G | 6.84e-07 | 1 / 0 | 3.42 | 0.072 | BENIGN | 0.93 | |
| 376 | p.Met376Thr | c.1127T>C | 6.84e-06 | 10 / 0 | 3.42 | 0.059 | BENIGN | 0.61 | rs758599432 |
| 376 | p.Met376Val | c.1126A>G | 6.84e-07 | 1 / 0 | 3.42 | - | nan | - | |
| 9 | p.Arg9His | c.26G>A | 2.68e-05 | 38 / 0 | 3.35 | 0.129 | BENIGN | 0.78 | rs762364309 |
| 9 | p.Arg9Cys | c.25C>T | 2.82e-06 | 4 / 0 | 3.35 | - | nan | - | rs770266068 |
| 287 | p.Trp287Cys | c.861G>T | 3.42e-06 | 5 / 0 | 3.34 | 0.999 | PATHOGENIC | 1.00 | rs757975302 |
| 12 | p.Pro12Leu | c.35C>T | 1.20e-05 | 17 / 0 | 3.29 | 0.089 | BENIGN | 0.47 | rs1007918697 |
| 11 | p.Glu11Asp | c.33G>C | 5.63e-06 | 8 / 0 | 3.29 | 0.066 | BENIGN | 0.68 | |
| 12 | p.Pro12Thr | c.34C>A | 7.04e-07 | 1 / 0 | 3.29 | - | nan | - | |
| 12 | p.Pro12Ser | c.34C>T | 7.04e-07 | 1 / 0 | 3.29 | - | nan | - | |
| 11 | p.Glu11Lys | c.31G>A | 3.52e-06 | 5 / 0 | 3.29 | - | nan | - | |
| 341 | p.Phe341Val | c.1021T>G | 6.84e-07 | 1 / 0 | 3.15 | 0.835 | PATHOGENIC | 0.99 | |
| 59 | p.Pro59Leu | c.176C>T | 4.11e-06 | 6 / 0 | 3.10 | 0.606 | PATHOGENIC | 0.59 | rs1807366599 |
| 59 | p.Pro59Arg | c.176C>G | 2.05e-06 | 3 / 0 | 3.10 | - | nan | - | |
| 59 | p.Pro59Ala | c.175C>G | 6.84e-07 | 1 / 0 | 3.10 | - | nan | - | rs1334272052 |
| 252 | p.Arg252Pro | c.755G>C | 2.05e-06 | 3 / 0 | 3.08 | 0.997 | PATHOGENIC | 1.00 | |
| 255 | p.Ser255Arg | c.765C>A | 6.84e-07 | 1 / 0 | 3.08 | 0.667 | PATHOGENIC | 0.94 | |
| 252 | p.Arg252His | c.755G>A | 1.03e-05 | 15 / 0 | 3.08 | - | nan | - | rs200672427 |
| 252 | p.Arg252Cys | c.754C>T | 3.42e-06 | 5 / 0 | 3.08 | - | nan | - | rs772138918 |
| 108 | p.Val108Ala | c.323T>C | 2.05e-06 | 3 / 0 | 3.08 | 0.725 | PATHOGENIC | 0.71 | rs765512539 |
| 108 | p.Val108Ile | c.322G>A | 6.84e-07 | 1 / 0 | 3.08 | - | nan | - | |
| 25 | p.Asn25Lys | c.75C>A | 2.75e-06 | 4 / 0 | 3.07 | 0.137 | BENIGN | 0.56 | rs751224173 |
| 25 | p.Asn25Ser | c.74A>G | 6.87e-06 | 10 / 0 | 3.07 | - | nan | - | rs998755241 |
| 25 | p.Asn25Asp | c.73A>G | 3.44e-06 | 5 / 0 | 3.07 | - | nan | - | rs1032860252 |
| 306 | p.Thr306Pro | c.916A>C | 5.75e-05 | 84 / 0 | 3.04 | 0.082 | BENIGN | 0.69 | rs199586709 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.56, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 6 | GLN | 202 | ARG | 12.524 | 0.000 | 12.524 | 12.524 |
| 202 | ARG | 204 | ASP | 10.555 | 0.970 | 9.585 | 9.585 |
| 119 | TYR | 313 | TYR | 12.520 | 3.063 | 9.457 | 9.457 |
| 266 | ASP | 270 | ARG | 1.495 | 10.910 | -9.414 | 9.414 |
| 140 | TYR | 183 | TRP | 10.748 | 2.177 | 8.571 | 8.571 |
| 90 | MET | 95 | ASN | 0.035 | 8.113 | -8.078 | 8.078 |
| 331 | ALA | 337 | PHE | 8.084 | 0.090 | 7.994 | 7.994 |
| 33 | TRP | 54 | ILE | 0.000 | 7.847 | -7.847 | 7.847 |
| 30 | PHE | 115 | GLN | 0.000 | 6.923 | -6.923 | 6.923 |
| 267 | ARG | 271 | ARG | 0.000 | 6.869 | -6.869 | 6.869 |
| 246 | TYR | 277 | LEU | 0.000 | 6.866 | -6.866 | 6.866 |
| 87 | TYR | 344 | PHE | 6.861 | 0.000 | 6.861 | 6.861 |
| 371 | ARG | 372 | ASP | 6.717 | 0.000 | 6.717 | 6.717 |
| 33 | TRP | 122 | ASN | 0.000 | 6.613 | -6.613 | 6.613 |
| 8 | PHE | 207 | VAL | 6.506 | 0.000 | 6.506 | 6.506 |
| 66 | TYR | 313 | TYR | 6.451 | 0.000 | 6.451 | 6.451 |
| 8 | PHE | 202 | ARG | 6.448 | 0.000 | 6.448 | 6.448 |
| 31 | PRO | 313 | TYR | 0.000 | 5.786 | -5.786 | 5.786 |
| 140 | TYR | 186 | SER | 8.438 | 2.654 | 5.784 | 5.784 |
| 370 | LEU | 371 | ARG | 5.780 | 0.000 | 5.780 | 5.780 |
| 258 | LEU | 265 | LYS | 5.672 | 0.000 | 5.672 | 5.672 |
| 107 | LEU | 141 | ASN | 5.595 | 0.000 | 5.595 | 5.595 |
| 264 | GLU | 267 | ARG | 5.524 | 0.000 | 5.524 | 5.524 |
| 372 | ASP | 373 | ILE | 5.222 | 0.000 | 5.222 | 5.222 |
| 156 | ARG | 170 | ARG | 0.000 | 5.203 | -5.203 | 5.203 |
| 293 | PHE | 312 | TYR | 5.083 | 10.283 | -5.200 | 5.200 |
| 6 | GLN | 304 | HIS | 5.106 | 0.000 | 5.106 | 5.106 |
| 114 | PHE | 126 | PHE | 1.820 | 6.751 | -4.931 | 4.931 |
| 8 | PHE | 209 | GLU | 4.880 | 0.000 | 4.880 | 4.880 |
| 155 | ASP | 156 | ARG | 0.000 | 4.789 | -4.789 | 4.789 |
| 140 | TYR | 187 | SER | 4.183 | 8.909 | -4.726 | 4.726 |
| 66 | TYR | 112 | MET | 7.830 | 3.108 | 4.721 | 4.721 |
| 146 | ILE | 283 | PHE | 0.680 | 5.387 | -4.707 | 4.707 |
| 27 | SER | 219 | TYR | 0.000 | 4.642 | -4.642 | 4.642 |
| 156 | ARG | 272 | ILE | 0.000 | 4.631 | -4.631 | 4.631 |
| 88 | THR | 95 | ASN | 4.597 | 0.000 | 4.597 | 4.597 |
| 259 | LEU | 265 | LYS | 4.555 | 0.000 | 4.555 | 4.555 |
| 81 | MET | 99 | PHE | 2.184 | 6.468 | -4.284 | 4.284 |
| 331 | ALA | 338 | LYS | 0.000 | 4.258 | -4.258 | 4.258 |
| 327 | PRO | 332 | PHE | 4.214 | 0.000 | 4.214 | 4.214 |
| 26 | SER | 297 | GLU | 0.000 | 4.201 | -4.201 | 4.201 |
| 156 | ARG | 246 | TYR | 4.180 | 0.000 | 4.180 | 4.180 |
| 105 | ASP | 141 | ASN | 0.000 | 4.135 | -4.135 | 4.135 |
| 271 | ARG | 335 | GLU | 4.636 | 0.574 | 4.062 | 4.062 |
| 231 | PHE | 295 | LEU | 4.043 | 0.000 | 4.043 | 4.043 |
| 66 | TYR | 119 | TYR | 0.000 | 3.948 | -3.948 | 3.948 |
| 111 | THR | 138 | ASP | 5.306 | 1.359 | 3.947 | 3.947 |
| 332 | PHE | 338 | LYS | 3.921 | 0.000 | 3.921 | 3.921 |
| 309 | LEU | 313 | TYR | 1.981 | 5.812 | -3.831 | 3.831 |
| 334 | ASP | 337 | PHE | 0.502 | 4.098 | -3.596 | 3.596 |
| 30 | PHE | 118 | VAL | 0.000 | 3.579 | -3.579 | 3.579 |
| 66 | TYR | 320 | TYR | 0.000 | 3.519 | -3.519 | 3.519 |
| 149 | LEU | 330 | TYR | 3.476 | 0.000 | 3.476 | 3.476 |
| 328 | ILE | 333 | LEU | 3.472 | 0.000 | 3.472 | 3.472 |
| 97 | TYR | 151 | MET | 0.316 | 3.753 | -3.436 | 3.436 |
| 376 | MET | 377 | ASN | 5.952 | 2.530 | 3.421 | 3.421 |
| 333 | LEU | 338 | LYS | 3.393 | 0.000 | 3.393 | 3.393 |
| 9 | ARG | 304 | HIS | 3.352 | 0.000 | 3.352 | 3.352 |
| 283 | PHE | 287 | TRP | 4.488 | 7.830 | -3.342 | 3.342 |
| 11 | GLU | 12 | PRO | 0.477 | 3.770 | -3.292 | 3.292 |
| 31 | PRO | 312 | TYR | 0.000 | 3.163 | -3.163 | 3.163 |
| 331 | ALA | 341 | PHE | 0.000 | 3.154 | -3.154 | 3.154 |
| 59 | PRO | 119 | TYR | 5.135 | 2.031 | 3.104 | 3.104 |
| 252 | ARG | 255 | SER | 3.084 | 0.000 | 3.084 | 3.084 |
| 108 | VAL | 320 | TYR | 3.809 | 0.734 | 3.075 | 3.075 |
| 111 | THR | 320 | TYR | 3.073 | 0.000 | 3.073 | 3.073 |
| 25 | ASN | 219 | TYR | 0.000 | 3.071 | -3.071 | 3.071 |
| 54 | ILE | 306 | THR | 3.950 | 0.906 | 3.044 | 3.044 |
| 94 | THR | 155 | ASP | 0.000 | 2.978 | -2.978 | 2.978 |
| 62 | ILE | 310 | SER | 2.966 | 0.000 | 2.966 | 2.966 |
| 249 | MET | 273 | THR | 0.000 | 2.961 | -2.961 | 2.961 |
| 94 | THR | 156 | ARG | 0.000 | 2.932 | -2.932 | 2.932 |
| 140 | TYR | 141 | ASN | 2.910 | 0.000 | 2.910 | 2.910 |
| 246 | TYR | 276 | VAL | 3.255 | 6.134 | -2.878 | 2.878 |
| 119 | TYR | 310 | SER | 2.877 | 0.000 | 2.877 | 2.877 |
| 156 | ARG | 330 | TYR | 2.852 | 0.000 | 2.852 | 2.852 |
| 108 | VAL | 141 | ASN | 3.318 | 6.138 | -2.819 | 2.819 |
| 296 | VAL | 301 | SER | 6.636 | 3.842 | 2.795 | 2.795 |
| 83 | VAL | 337 | PHE | 3.865 | 1.075 | 2.790 | 2.790 |
| 8 | PHE | 205 | VAL | 2.775 | 0.000 | 2.775 | 2.775 |
| 369 | TYR | 370 | LEU | 2.730 | 0.000 | 2.730 | 2.730 |
| 27 | SER | 212 | LEU | 0.000 | 2.692 | -2.692 | 2.692 |
| 33 | TRP | 313 | TYR | 0.000 | 2.672 | -2.672 | 2.672 |
| 105 | ASP | 326 | ASN | 5.583 | 2.914 | 2.669 | 2.669 |
| 27 | SER | 211 | SER | 0.000 | 2.662 | -2.662 | 2.662 |
| 30 | PHE | 210 | CYS | 0.000 | 2.639 | -2.639 | 2.639 |
| 26 | SER | 227 | LYS | 0.000 | 2.592 | -2.592 | 2.592 |
| 118 | VAL | 313 | TYR | 2.555 | 0.000 | 2.555 | 2.555 |
| 96 | ILE | 179 | ASN | 1.140 | 3.672 | -2.531 | 2.531 |
| 147 | PHE | 185 | LEU | 1.900 | 4.381 | -2.482 | 2.482 |
| 84 | ILE | 89 | LYS | 2.480 | 0.000 | 2.480 | 2.480 |
| 79 | LEU | 341 | PHE | 1.168 | 3.617 | -2.449 | 2.449 |
| 9 | ARG | 306 | THR | 2.434 | 0.000 | 2.434 | 2.434 |
| 253 | LEU | 259 | LEU | 2.423 | 0.000 | 2.423 | 2.423 |
| 279 | VAL | 330 | TYR | 2.496 | 0.098 | 2.398 | 2.398 |
| 204 | ASP | 205 | VAL | 2.561 | 0.174 | 2.387 | 2.387 |
| 100 | ASN | 148 | THR | 0.164 | 2.542 | -2.378 | 2.378 |
| 7 | ILE | 209 | GLU | 2.373 | 0.000 | 2.373 | 2.373 |
| 157 | TYR | 245 | CYS | 4.622 | 2.254 | 2.367 | 2.367 |
| 275 | LEU | 330 | TYR | 0.000 | 2.356 | -2.356 | 2.356 |
| 77 | ASN | 106 | ALA | 4.010 | 1.676 | 2.334 | 2.334 |
| 90 | MET | 337 | PHE | 0.000 | 2.325 | -2.325 | 2.325 |
| 214 | PHE | 219 | TYR | 7.147 | 4.862 | 2.285 | 2.285 |
| 98 | ILE | 330 | TYR | 0.940 | 3.191 | -2.251 | 2.251 |
| 115 | GLN | 313 | TYR | 2.248 | 0.000 | 2.248 | 2.248 |
| 250 | ILE | 273 | THR | 2.232 | 0.000 | 2.232 | 2.232 |
| 149 | LEU | 326 | ASN | 2.205 | 0.000 | 2.205 | 2.205 |
| 8 | PHE | 122 | ASN | 2.201 | 0.000 | 2.201 | 2.201 |
| 330 | TYR | 337 | PHE | 0.000 | 2.183 | -2.183 | 2.183 |
| 287 | TRP | 322 | ASN | 4.331 | 2.156 | 2.175 | 2.175 |
| 139 | TYR | 193 | ALA | 0.000 | 2.155 | -2.155 | 2.155 |
| 160 | VAL | 269 | LEU | 0.000 | 2.141 | -2.141 | 2.141 |
| 322 | ASN | 326 | ASN | 2.201 | 0.067 | 2.134 | 2.134 |
| 341 | PHE | 345 | CYS | 2.122 | 0.000 | 2.122 | 2.122 |
| 140 | TYR | 190 | GLY | 0.753 | 2.870 | -2.116 | 2.116 |
| 259 | LEU | 266 | ASP | 2.109 | 0.000 | 2.109 | 2.109 |
| 89 | LYS | 95 | ASN | 2.089 | 0.000 | 2.089 | 2.089 |
| 128 | ASP | 132 | LYS | 3.753 | 5.805 | -2.052 | 2.052 |
| 202 | ARG | 209 | GLU | 0.664 | 2.689 | -2.024 | 2.024 |
| 152 | MET | 330 | TYR | 2.107 | 0.100 | 2.007 | 2.007 |
| 293 | PHE | 311 | SER | 2.004 | 0.000 | 2.004 | 2.004 |
| 214 | PHE | 222 | TRP | 2.130 | 4.128 | -1.998 | 1.998 |
| 86 | ARG | 87 | TYR | 2.720 | 0.725 | 1.995 | 1.995 |
| 114 | PHE | 134 | VAL | 2.600 | 0.609 | 1.991 | 1.991 |
| 105 | ASP | 145 | SER | 3.291 | 1.311 | 1.979 | 1.979 |
| 77 | ASN | 105 | ASP | 5.382 | 3.404 | 1.978 | 1.978 |
| 246 | TYR | 273 | THR | 0.000 | 1.949 | -1.949 | 1.949 |
| 169 | PHE | 174 | LYS | 4.812 | 2.864 | 1.947 | 1.947 |
| 142 | MET | 291 | HIS | 0.000 | 1.917 | -1.917 | 1.917 |
| 141 | ASN | 145 | SER | 0.000 | 1.908 | -1.908 | 1.908 |
| 66 | TYR | 317 | ALA | 3.441 | 1.536 | 1.906 | 1.906 |
| 365 | GLN | 366 | ASP | 1.877 | 0.000 | 1.877 | 1.877 |
| 136 | SER | 140 | TYR | 0.000 | 1.872 | -1.872 | 1.872 |
| 54 | ILE | 307 | ALA | 1.836 | 0.000 | 1.836 | 1.836 |
| 114 | PHE | 130 | LEU | 1.430 | 3.248 | -1.818 | 1.818 |
| 28 | ALA | 211 | SER | 0.000 | 1.813 | -1.813 | 1.813 |
| 79 | LEU | 344 | PHE | 0.055 | 1.861 | -1.806 | 1.806 |
| 108 | VAL | 137 | ILE | 0.000 | 1.799 | -1.799 | 1.799 |
| 115 | GLN | 134 | VAL | 0.000 | 1.792 | -1.792 | 1.792 |
| 29 | TRP | 139 | TYR | 0.000 | 1.788 | -1.788 | 1.788 |
| 63 | THR | 116 | SER | 0.895 | 2.677 | -1.782 | 1.782 |
| 76 | GLY | 327 | PRO | 2.450 | 4.225 | -1.775 | 1.775 |
| 268 | ASN | 272 | ILE | 0.000 | 1.773 | -1.773 | 1.773 |
| 62 | ILE | 313 | TYR | 0.133 | 1.906 | -1.773 | 1.773 |
| 139 | TYR | 212 | LEU | 0.663 | 2.431 | -1.768 | 1.768 |
| 73 | GLY | 109 | THR | 0.824 | 2.588 | -1.764 | 1.764 |
| 286 | CYS | 318 | LEU | 6.118 | 7.879 | -1.761 | 1.761 |
| 235 | PHE | 287 | TRP | 1.736 | 0.000 | 1.736 | 1.736 |
| 52 | ALA | 306 | THR | 0.000 | 1.729 | -1.729 | 1.729 |
| 143 | PHE | 189 | VAL | 2.651 | 4.369 | -1.718 | 1.718 |
| 82 | PHE | 344 | PHE | 1.718 | 0.000 | 1.718 | 1.718 |
| 96 | ILE | 175 | ALA | 0.571 | 2.279 | -1.709 | 1.709 |
| 159 | ALA | 170 | ARG | 0.723 | 2.425 | -1.702 | 1.702 |
| 83 | VAL | 88 | THR | 1.698 | 0.000 | 1.698 | 1.698 |
| 84 | ILE | 88 | THR | 1.697 | 0.000 | 1.697 | 1.697 |
| 101 | LEU | 149 | LEU | 2.276 | 0.611 | 1.665 | 1.665 |
| 4 | PRO | 5 | ILE | 0.000 | 1.665 | -1.665 | 1.665 |
| 69 | VAL | 112 | MET | 2.615 | 0.952 | 1.663 | 1.663 |
| 283 | PHE | 322 | ASN | 2.272 | 3.916 | -1.645 | 1.645 |
| 136 | SER | 190 | GLY | 3.446 | 1.805 | 1.641 | 1.641 |
| 25 | ASN | 209 | GLU | 0.000 | 1.640 | -1.640 | 1.640 |
| 124 | TRP | 130 | LEU | 1.671 | 3.301 | -1.629 | 1.629 |
| 83 | VAL | 340 | CYS | 0.000 | 1.601 | -1.601 | 1.601 |
| 290 | ILE | 315 | CYS | 3.888 | 5.482 | -1.594 | 1.594 |
| 286 | CYS | 322 | ASN | 3.084 | 1.496 | 1.587 | 1.587 |
| 97 | TYR | 175 | ALA | 2.025 | 3.592 | -1.567 | 1.567 |
| 151 | MET | 169 | PHE | 0.095 | 1.648 | -1.553 | 1.553 |
| 368 | ALA | 369 | TYR | 1.533 | 0.000 | 1.533 | 1.533 |
| 74 | LEU | 109 | THR | 1.344 | 2.876 | -1.532 | 1.532 |
| 242 | ILE | 280 | VAL | 0.570 | 2.092 | -1.522 | 1.522 |
| 287 | TRP | 291 | HIS | 2.147 | 0.626 | 1.522 | 1.522 |
| 149 | LEU | 283 | PHE | 0.978 | 2.480 | -1.502 | 1.502 |
| 373 | ILE | 374 | ASP | 1.498 | 0.000 | 1.498 | 1.498 |
| 146 | ILE | 238 | PRO | 1.456 | 2.951 | -1.495 | 1.495 |
| 246 | TYR | 249 | MET | 1.509 | 2.998 | -1.489 | 1.489 |
| 279 | VAL | 329 | LEU | 0.075 | 1.559 | -1.484 | 1.484 |
| 54 | ILE | 309 | LEU | 0.000 | 1.483 | -1.483 | 1.483 |
| 90 | MET | 96 | ILE | 1.471 | 0.000 | 1.471 | 1.471 |
| 140 | TYR | 144 | THR | 1.551 | 0.087 | 1.465 | 1.465 |
| 117 | THR | 126 | PHE | 2.137 | 3.594 | -1.456 | 1.456 |
| 80 | VAL | 331 | ALA | 1.447 | 0.000 | 1.447 | 1.447 |
| 124 | TRP | 126 | PHE | 6.300 | 4.870 | 1.430 | 1.430 |
| 72 | VAL | 324 | SER | 0.387 | 1.801 | -1.414 | 1.414 |
| 231 | PHE | 235 | PHE | 3.148 | 1.742 | 1.406 | 1.406 |
| 289 | PRO | 315 | CYS | 1.891 | 3.296 | -1.405 | 1.405 |
| 104 | ALA | 141 | ASN | 2.907 | 4.310 | -1.403 | 1.403 |
| 146 | ILE | 287 | TRP | 1.396 | 0.000 | 1.396 | 1.396 |
| 303 | SER | 305 | SER | 0.679 | 2.073 | -1.394 | 1.394 |
| 66 | TYR | 115 | GLN | 0.633 | 2.025 | -1.392 | 1.392 |
| 27 | SER | 223 | ASP | 0.000 | 1.376 | -1.376 | 1.376 |
| 168 | ASP | 174 | LYS | 5.698 | 4.332 | 1.365 | 1.365 |
| 118 | VAL | 123 | SER | 1.737 | 3.100 | -1.363 | 1.363 |
| 140 | TYR | 191 | ILE | 0.000 | 1.345 | -1.345 | 1.345 |
| 70 | PHE | 109 | THR | 2.270 | 3.602 | -1.332 | 1.332 |
| 136 | SER | 193 | ALA | 1.543 | 0.218 | 1.324 | 1.324 |
| 155 | ASP | 170 | ARG | 8.203 | 6.888 | 1.315 | 1.315 |
| 93 | ALA | 170 | ARG | 1.189 | 2.491 | -1.302 | 1.302 |
| 142 | MET | 234 | ALA | 0.130 | 1.427 | -1.297 | 1.297 |
| 205 | VAL | 207 | VAL | 0.539 | 1.818 | -1.279 | 1.279 |
| 314 | PHE | 318 | LEU | 1.363 | 0.085 | 1.278 | 1.278 |
| 123 | SER | 208 | ILE | 4.023 | 5.298 | -1.275 | 1.275 |
| 121 | MET | 125 | PRO | 1.266 | 2.528 | -1.262 | 1.262 |
| 22 | LEU | 23 | PRO | 1.645 | 0.391 | 1.255 | 1.255 |
| 328 | ILE | 332 | PHE | 0.118 | 1.367 | -1.249 | 1.249 |
| 239 | VAL | 283 | PHE | 1.247 | 0.000 | 1.247 | 1.247 |
| 279 | VAL | 326 | ASN | 0.000 | 1.220 | -1.220 | 1.220 |
| 108 | VAL | 142 | MET | 1.213 | 0.000 | 1.213 | 1.213 |
| 100 | ASN | 144 | THR | 0.000 | 1.212 | -1.212 | 1.212 |
| 143 | PHE | 186 | SER | 2.001 | 3.206 | -1.205 | 1.205 |
| 212 | LEU | 219 | TYR | 1.306 | 0.104 | 1.201 | 1.201 |
| 149 | LEU | 279 | VAL | 0.000 | 1.200 | -1.200 | 1.200 |
| 87 | TYR | 340 | CYS | 0.526 | 1.716 | -1.190 | 1.190 |
| 343 | ASP | 350 | MET | 0.000 | 1.185 | -1.185 | 1.185 |
| 379 | PRO | 380 | VAL | 1.252 | 0.079 | 1.173 | 1.173 |
| 84 | ILE | 90 | MET | 0.231 | 1.402 | -1.172 | 1.172 |
| 287 | TRP | 319 | GLY | 0.336 | 1.506 | -1.170 | 1.170 |
| 161 | CYS | 252 | ARG | 1.304 | 2.471 | -1.167 | 1.167 |
| 285 | VAL | 318 | LEU | 0.087 | 1.253 | -1.166 | 1.166 |
| 97 | TYR | 148 | THR | 1.132 | 2.295 | -1.163 | 1.163 |
| 150 | THR | 242 | ILE | 1.295 | 2.454 | -1.160 | 1.160 |
| 5 | ILE | 297 | GLU | 1.157 | 0.000 | 1.157 | 1.157 |
| 111 | THR | 137 | ILE | 0.751 | 1.908 | -1.157 | 1.157 |
| 103 | LEU | 183 | TRP | 1.784 | 0.627 | 1.157 | 1.157 |
| 290 | ILE | 312 | TYR | 1.156 | 0.000 | 1.156 | 1.156 |
| 152 | MET | 276 | VAL | 0.000 | 1.155 | -1.155 | 1.155 |
| 63 | THR | 120 | LEU | 2.624 | 3.769 | -1.145 | 1.145 |
| 62 | ILE | 66 | TYR | 1.350 | 2.491 | -1.141 | 1.141 |
| 221 | TRP | 225 | PHE | 0.083 | 1.223 | -1.140 | 1.140 |
| 332 | PHE | 337 | PHE | 1.139 | 0.000 | 1.139 | 1.139 |
| 55 | SER | 57 | ALA | 0.000 | 1.117 | -1.117 | 1.117 |
| 44 | SER | 45 | GLU | 1.625 | 0.509 | 1.116 | 1.116 |
| 137 | ILE | 141 | ASN | 1.114 | 0.000 | 1.114 | 1.114 |
| 114 | PHE | 124 | TRP | 1.976 | 0.870 | 1.107 | 1.107 |
| 84 | ILE | 95 | ASN | 0.843 | 1.946 | -1.104 | 1.104 |
| 252 | ARG | 256 | VAL | 0.784 | 1.884 | -1.101 | 1.101 |
| 128 | ASP | 199 | THR | 7.063 | 5.963 | 1.099 | 1.099 |
| 97 | TYR | 179 | ASN | 4.641 | 3.543 | 1.098 | 1.098 |
| 153 | SER | 245 | CYS | 2.488 | 1.391 | 1.097 | 1.097 |
| 253 | LEU | 269 | LEU | 1.083 | 0.000 | 1.083 | 1.083 |
| 286 | CYS | 319 | GLY | 1.304 | 2.385 | -1.081 | 1.081 |
| 45 | GLU | 46 | ASP | 1.079 | 0.000 | 1.079 | 1.079 |
| 107 | LEU | 137 | ILE | 0.589 | 1.666 | -1.078 | 1.078 |
| 69 | VAL | 321 | THR | 2.999 | 1.931 | 1.068 | 1.068 |
| 132 | LYS | 197 | GLY | 5.649 | 4.582 | 1.067 | 1.067 |
| 101 | LEU | 148 | THR | 1.791 | 0.730 | 1.061 | 1.061 |
| 199 | THR | 213 | GLN | 1.560 | 0.506 | 1.054 | 1.054 |
| 345 | CYS | 346 | PHE | 0.000 | 1.035 | -1.035 | 1.035 |
| 141 | ASN | 323 | SER | 0.000 | 1.029 | -1.029 | 1.029 |
| 312 | TYR | 316 | ILE | 3.360 | 4.384 | -1.024 | 1.024 |
| 32 | GLY | 122 | ASN | 0.000 | 1.023 | -1.023 | 1.023 |
| 29 | TRP | 316 | ILE | 0.000 | 1.020 | -1.020 | 1.020 |
| 212 | LEU | 226 | MET | 1.018 | 0.000 | 1.018 | 1.018 |
| 89 | LYS | 91 | LYS | 1.015 | 0.000 | 1.015 | 1.015 |
| 142 | MET | 230 | VAL | 0.412 | 1.427 | -1.014 | 1.014 |
| 138 | ASP | 320 | TYR | 4.118 | 5.131 | -1.013 | 1.013 |
| 142 | MET | 143 | PHE | 1.239 | 0.227 | 1.012 | 1.012 |
| 264 | GLU | 268 | ASN | 1.010 | 0.000 | 1.010 | 1.010 |
| 79 | LEU | 332 | PHE | 1.009 | 0.000 | 1.009 | 1.009 |
| 111 | THR | 134 | VAL | 1.201 | 2.208 | -1.007 | 1.007 |
| 66 | TYR | 316 | ILE | 2.558 | 1.555 | 1.003 | 1.003 |
| 77 | ASN | 323 | SER | 1.515 | 2.500 | -0.985 | 0.985 |
| 104 | ALA | 145 | SER | 1.374 | 0.399 | 0.975 | 0.975 |
| 327 | PRO | 341 | PHE | 0.000 | 0.973 | -0.973 | 0.973 |
| 366 | ASP | 367 | PRO | 2.642 | 1.678 | 0.965 | 0.965 |
| 83 | VAL | 90 | MET | 0.000 | 0.962 | -0.962 | 0.962 |
| 69 | VAL | 324 | SER | 4.430 | 5.388 | -0.958 | 0.958 |
| 153 | SER | 276 | VAL | 0.000 | 0.955 | -0.955 | 0.955 |
| 87 | TYR | 90 | MET | 0.000 | 0.951 | -0.951 | 0.951 |
| 119 | TYR | 316 | ILE | 0.000 | 0.942 | -0.942 | 0.942 |
| 126 | PHE | 130 | LEU | 1.735 | 2.675 | -0.940 | 0.940 |
| 282 | VAL | 329 | LEU | 1.406 | 0.470 | 0.936 | 0.936 |
| 143 | PHE | 230 | VAL | 1.443 | 0.520 | 0.922 | 0.922 |
| 290 | ILE | 319 | GLY | 0.000 | 0.922 | -0.922 | 0.922 |
| 88 | THR | 340 | CYS | 0.913 | 0.000 | 0.913 | 0.913 |
| 124 | TRP | 131 | CYS | 5.772 | 6.684 | -0.911 | 0.911 |
| 196 | LEU | 226 | MET | 0.000 | 0.905 | -0.905 | 0.905 |
| 101 | LEU | 326 | ASN | 1.156 | 2.061 | -0.905 | 0.905 |
| 338 | LYS | 342 | ARG | 0.000 | 0.904 | -0.904 | 0.904 |
| 290 | ILE | 316 | ILE | 1.452 | 2.353 | -0.901 | 0.901 |
| 37 | ASP | 38 | SER | 0.899 | 0.000 | 0.899 | 0.899 |
| 256 | VAL | 258 | LEU | 0.891 | 0.000 | 0.891 | 0.891 |
| 282 | VAL | 325 | LEU | 0.591 | 1.478 | -0.887 | 0.887 |
| 278 | VAL | 333 | LEU | 0.000 | 0.881 | -0.881 | 0.881 |
| 96 | ILE | 172 | PRO | 1.986 | 2.867 | -0.880 | 0.880 |
| 160 | VAL | 252 | ARG | 2.141 | 1.261 | 0.880 | 0.880 |
| 69 | VAL | 109 | THR | 0.000 | 0.877 | -0.877 | 0.877 |
| 29 | TRP | 290 | ILE | 0.000 | 0.877 | -0.877 | 0.877 |
| 34 | ALA | 202 | ARG | 0.000 | 0.876 | -0.876 | 0.876 |
| 100 | ASN | 183 | TRP | 3.356 | 4.232 | -0.875 | 0.875 |
| 100 | ASN | 179 | ASN | 6.625 | 7.493 | -0.868 | 0.868 |
| 211 | SER | 213 | GLN | 0.986 | 1.850 | -0.864 | 0.864 |
| 156 | ARG | 276 | VAL | 0.000 | 0.864 | -0.864 | 0.864 |
| 144 | THR | 183 | TRP | 1.733 | 2.594 | -0.861 | 0.861 |
| 85 | ILE | 99 | PHE | 1.006 | 1.865 | -0.859 | 0.859 |
| 93 | ALA | 171 | THR | 0.306 | 1.164 | -0.858 | 0.858 |
| 5 | ILE | 298 | ALA | 0.857 | 0.000 | 0.857 | 0.857 |
| 101 | LEU | 105 | ASP | 2.781 | 1.934 | 0.847 | 0.847 |
| 227 | LYS | 298 | ALA | 0.843 | 0.000 | 0.843 | 0.843 |
| 33 | TRP | 309 | LEU | 0.000 | 0.842 | -0.842 | 0.842 |
| 214 | PHE | 226 | MET | 1.253 | 2.087 | -0.833 | 0.833 |
| 83 | VAL | 87 | TYR | 0.182 | 1.006 | -0.824 | 0.824 |
| 215 | PRO | 222 | TRP | 0.000 | 0.810 | -0.810 | 0.810 |
| 332 | PHE | 341 | PHE | 0.799 | 0.000 | 0.799 | 0.799 |
| 249 | MET | 276 | VAL | 0.793 | 0.000 | 0.793 | 0.793 |
| 125 | PRO | 126 | PHE | 3.885 | 4.677 | -0.792 | 0.792 |
| 96 | ILE | 100 | ASN | 0.791 | 0.000 | 0.791 | 0.791 |
| 271 | ARG | 338 | LYS | 0.791 | 0.000 | 0.791 | 0.791 |
| 201 | VAL | 207 | VAL | 1.430 | 2.219 | -0.789 | 0.789 |
| 31 | PRO | 309 | LEU | 0.000 | 0.783 | -0.783 | 0.783 |
| 101 | LEU | 145 | SER | 2.268 | 3.046 | -0.778 | 0.778 |
| 29 | TRP | 30 | PHE | 1.067 | 0.289 | 0.777 | 0.777 |
| 143 | PHE | 147 | PHE | 3.349 | 2.573 | 0.776 | 0.776 |
| 29 | TRP | 119 | TYR | 0.000 | 0.775 | -0.775 | 0.775 |
| 58 | ILE | 119 | TYR | 0.775 | 0.000 | 0.775 | 0.775 |
| 111 | THR | 112 | MET | 0.000 | 0.774 | -0.774 | 0.774 |
| 151 | MET | 182 | ILE | 1.015 | 0.241 | 0.774 | 0.774 |
| 158 | ILE | 166 | ALA | 1.757 | 2.527 | -0.770 | 0.770 |
| 108 | VAL | 138 | ASP | 0.644 | 1.413 | -0.769 | 0.769 |
| 35 | GLU | 36 | PRO | 1.546 | 0.786 | 0.760 | 0.760 |
| 202 | ARG | 205 | VAL | 1.241 | 2.000 | -0.759 | 0.759 |
| 223 | ASP | 227 | LYS | 6.800 | 7.547 | -0.747 | 0.747 |
| 278 | VAL | 329 | LEU | 0.582 | 1.324 | -0.743 | 0.743 |
| 101 | LEU | 152 | MET | 0.773 | 0.035 | 0.738 | 0.738 |
| 235 | PHE | 239 | VAL | 1.775 | 1.040 | 0.735 | 0.735 |
| 329 | LEU | 330 | TYR | 0.728 | 0.000 | 0.728 | 0.728 |
| 346 | PHE | 347 | PRO | 0.824 | 0.106 | 0.718 | 0.718 |
| 136 | SER | 194 | ILE | 2.923 | 3.638 | -0.716 | 0.716 |
| 200 | LYS | 213 | GLN | 4.450 | 3.737 | 0.713 | 0.713 |
| 226 | MET | 230 | VAL | 0.711 | 0.000 | 0.711 | 0.711 |
| 84 | ILE | 337 | PHE | 0.205 | 0.906 | -0.702 | 0.702 |
| 144 | THR | 182 | ILE | 1.038 | 1.733 | -0.695 | 0.695 |
| 70 | PHE | 110 | THR | 0.031 | 0.725 | -0.694 | 0.694 |
| 115 | GLN | 138 | ASP | 0.457 | 1.141 | -0.684 | 0.684 |
| 124 | TRP | 210 | CYS | 5.476 | 4.797 | 0.679 | 0.679 |
| 146 | ILE | 234 | ALA | 3.627 | 2.950 | 0.678 | 0.678 |
| 326 | ASN | 330 | TYR | 1.560 | 0.883 | 0.677 | 0.677 |
| 118 | VAL | 124 | TRP | 1.210 | 1.885 | -0.675 | 0.675 |
| 72 | VAL | 328 | ILE | 0.000 | 0.670 | -0.670 | 0.670 |
| 28 | ALA | 312 | TYR | 0.000 | 0.668 | -0.668 | 0.668 |
| 235 | PHE | 291 | HIS | 4.142 | 4.799 | -0.657 | 0.657 |
| 132 | LYS | 195 | VAL | 0.653 | 0.000 | 0.653 | 0.653 |
| 341 | PHE | 344 | PHE | 0.652 | 0.000 | 0.652 | 0.652 |
| 117 | THR | 125 | PRO | 0.000 | 0.649 | -0.649 | 0.649 |
| 166 | ALA | 170 | ARG | 0.000 | 0.649 | -0.649 | 0.649 |
| 27 | SER | 28 | ALA | 0.649 | 0.000 | 0.649 | 0.649 |
| 293 | PHE | 308 | ALA | 1.614 | 2.257 | -0.643 | 0.643 |
| 246 | TYR | 280 | VAL | 0.914 | 0.276 | 0.637 | 0.637 |
| 153 | SER | 241 | ILE | 0.634 | 0.000 | 0.634 | 0.634 |
| 142 | MET | 146 | ILE | 0.631 | 0.000 | 0.631 | 0.631 |
| 254 | LYS | 269 | LEU | 0.631 | 0.000 | 0.631 | 0.631 |
| 77 | ASN | 102 | ALA | 6.761 | 6.130 | 0.630 | 0.630 |
| 151 | MET | 154 | VAL | 0.717 | 1.347 | -0.630 | 0.630 |
| 212 | LEU | 214 | PHE | 0.681 | 1.310 | -0.629 | 0.629 |
| 169 | PHE | 178 | ILE | 1.531 | 0.902 | 0.629 | 0.629 |
| 339 | ARG | 343 | ASP | 0.000 | 0.626 | -0.626 | 0.626 |
| 312 | TYR | 313 | TYR | 0.871 | 0.245 | 0.625 | 0.625 |
| 145 | SER | 326 | ASN | 0.624 | 0.000 | 0.624 | 0.624 |
| 97 | TYR | 178 | ILE | 2.996 | 3.619 | -0.623 | 0.623 |
| 171 | THR | 174 | LYS | 2.169 | 2.789 | -0.620 | 0.620 |
| 234 | ALA | 291 | HIS | 0.640 | 0.020 | 0.620 | 0.620 |
| 80 | VAL | 330 | TYR | 0.000 | 0.616 | -0.616 | 0.616 |
| 214 | PHE | 223 | ASP | 4.769 | 5.377 | -0.608 | 0.608 |
| 73 | GLY | 324 | SER | 4.309 | 3.703 | 0.607 | 0.607 |
| 344 | PHE | 348 | LEU | 0.595 | 0.000 | 0.595 | 0.595 |
| 84 | ILE | 98 | ILE | 1.549 | 0.969 | 0.580 | 0.580 |
| 235 | PHE | 288 | THR | 4.357 | 4.932 | -0.575 | 0.575 |
| 275 | LEU | 333 | LEU | 1.214 | 1.789 | -0.575 | 0.575 |
| 30 | PHE | 31 | PRO | 0.751 | 0.180 | 0.571 | 0.571 |
| 257 | ARG | 270 | ARG | 0.000 | 0.569 | -0.569 | 0.569 |
| 356 | SER | 357 | THR | 0.565 | 0.000 | 0.565 | 0.565 |
| 158 | ILE | 169 | PHE | 3.904 | 3.340 | 0.564 | 0.564 |
| 108 | VAL | 323 | SER | 1.008 | 1.571 | -0.563 | 0.563 |
| 24 | PRO | 304 | HIS | 0.000 | 0.562 | -0.562 | 0.562 |
| 313 | TYR | 316 | ILE | 0.560 | 0.000 | 0.560 | 0.560 |
| 95 | ASN | 98 | ILE | 0.000 | 0.560 | -0.560 | 0.560 |
| 153 | SER | 280 | VAL | 0.000 | 0.558 | -0.558 | 0.558 |
| 337 | PHE | 341 | PHE | 0.429 | 0.984 | -0.556 | 0.556 |
| 85 | ILE | 91 | LYS | 0.000 | 0.551 | -0.551 | 0.551 |
| 94 | THR | 98 | ILE | 0.695 | 0.144 | 0.550 | 0.550 |
| 10 | GLY | 306 | THR | 0.550 | 0.000 | 0.550 | 0.550 |
| 80 | VAL | 337 | PHE | 1.420 | 1.966 | -0.546 | 0.546 |
| 342 | ARG | 346 | PHE | 0.000 | 0.546 | -0.546 | 0.546 |
| 105 | ASP | 323 | SER | 8.833 | 8.294 | 0.539 | 0.539 |
| 58 | ILE | 313 | TYR | 0.000 | 0.539 | -0.539 | 0.539 |
| 346 | PHE | 350 | MET | 0.539 | 0.000 | 0.539 | 0.539 |
| 187 | SER | 191 | ILE | 0.041 | 0.577 | -0.535 | 0.535 |
| 94 | THR | 170 | ARG | 1.971 | 1.437 | 0.534 | 0.534 |
| 223 | ASP | 226 | MET | 0.534 | 0.000 | 0.534 | 0.534 |
| 7 | ILE | 202 | ARG | 0.533 | 0.000 | 0.533 | 0.533 |
| 146 | ILE | 147 | PHE | 0.074 | 0.603 | -0.529 | 0.529 |
| 70 | PHE | 113 | PRO | 1.958 | 2.485 | -0.527 | 0.527 |
| 50 | GLU | 51 | PRO | 1.061 | 0.536 | 0.525 | 0.525 |
| 119 | TYR | 120 | LEU | 0.523 | 0.000 | 0.523 | 0.523 |
| 290 | ILE | 294 | ILE | 1.307 | 0.794 | 0.513 | 0.513 |
| 33 | TRP | 59 | PRO | 0.000 | 0.509 | -0.509 | 0.509 |
| 246 | TYR | 279 | VAL | 0.503 | 0.000 | 0.503 | 0.503 |
| 157 | TYR | 248 | LEU | 2.691 | 3.194 | -0.503 | 0.503 |
| 262 | SER | 265 | LYS | 0.686 | 0.184 | 0.502 | 0.502 |
| 74 | LEU | 110 | THR | 0.015 | 0.515 | -0.500 | 0.500 |
| 80 | VAL | 327 | PRO | 0.905 | 0.406 | 0.499 | 0.499 |
| 124 | TRP | 134 | VAL | 0.703 | 1.195 | -0.493 | 0.493 |
| 131 | CYS | 210 | CYS | 6.539 | 7.028 | -0.488 | 0.488 |
| 38 | SER | 39 | ASN | 0.488 | 0.000 | 0.488 | 0.488 |
| 275 | LEU | 329 | LEU | 0.265 | 0.749 | -0.484 | 0.484 |
| 249 | MET | 250 | ILE | 0.484 | 0.000 | 0.484 | 0.484 |
| 153 | SER | 246 | TYR | 2.497 | 2.013 | 0.484 | 0.484 |
| 335 | GLU | 338 | LYS | 1.558 | 1.077 | 0.481 | 0.481 |
| 101 | LEU | 330 | TYR | 1.201 | 0.721 | 0.481 | 0.481 |
| 243 | ILE | 280 | VAL | 0.480 | 0.000 | 0.480 | 0.480 |
| 70 | PHE | 112 | MET | 1.674 | 1.197 | 0.477 | 0.477 |
| 25 | ASN | 26 | SER | 0.462 | 0.000 | 0.462 | 0.462 |
| 148 | THR | 182 | ILE | 1.448 | 1.907 | -0.459 | 0.459 |
| 82 | PHE | 86 | ARG | 0.000 | 0.458 | -0.458 | 0.458 |
| 218 | ASP | 222 | TRP | 1.077 | 1.530 | -0.453 | 0.453 |
| 14 | PRO | 15 | THR | 0.000 | 0.451 | -0.451 | 0.451 |
| 286 | CYS | 321 | THR | 0.448 | 0.000 | 0.448 | 0.448 |
| 123 | SER | 207 | VAL | 2.295 | 1.849 | 0.446 | 0.446 |
| 93 | ALA | 175 | ALA | 1.761 | 2.205 | -0.444 | 0.444 |
| 90 | MET | 336 | ASN | 0.000 | 0.444 | -0.444 | 0.444 |
| 260 | SER | 266 | ASP | 0.440 | 0.000 | 0.440 | 0.440 |
| 132 | LYS | 194 | ILE | 2.382 | 2.820 | -0.438 | 0.438 |
| 233 | PHE | 237 | ILE | 1.344 | 0.906 | 0.438 | 0.438 |
| 28 | ALA | 210 | CYS | 0.000 | 0.431 | -0.431 | 0.431 |
| 157 | TYR | 161 | CYS | 3.610 | 3.181 | 0.429 | 0.429 |
| 303 | SER | 308 | ALA | 1.005 | 1.434 | -0.428 | 0.428 |
| 267 | ARG | 270 | ARG | 0.537 | 0.110 | 0.427 | 0.427 |
| 155 | ASP | 169 | PHE | 0.473 | 0.046 | 0.426 | 0.426 |
| 115 | GLN | 320 | TYR | 1.845 | 2.268 | -0.424 | 0.424 |
| 149 | LEU | 322 | ASN | 0.422 | 0.000 | 0.422 | 0.422 |
| 145 | SER | 149 | LEU | 0.421 | 0.000 | 0.421 | 0.421 |
| 143 | PHE | 234 | ALA | 1.732 | 2.149 | -0.417 | 0.417 |
| 115 | GLN | 124 | TRP | 0.000 | 0.413 | -0.413 | 0.413 |
| 65 | VAL | 321 | THR | 0.000 | 0.409 | -0.409 | 0.409 |
| 169 | PHE | 170 | ARG | 0.000 | 0.404 | -0.404 | 0.404 |
| 246 | TYR | 330 | TYR | 0.402 | 0.000 | 0.402 | 0.402 |
| 109 | THR | 323 | SER | 0.104 | 0.505 | -0.401 | 0.401 |
| 286 | CYS | 325 | LEU | 0.000 | 0.398 | -0.398 | 0.398 |
| 130 | LEU | 134 | VAL | 0.701 | 0.303 | 0.398 | 0.398 |
| 224 | LEU | 228 | ILE | 1.238 | 1.635 | -0.397 | 0.397 |
| 70 | PHE | 74 | LEU | 1.024 | 1.421 | -0.396 | 0.396 |
| 344 | PHE | 345 | CYS | 0.395 | 0.000 | 0.395 | 0.395 |
| 148 | THR | 179 | ASN | 0.394 | 0.000 | 0.394 | 0.394 |
| 159 | ALA | 269 | LEU | 0.000 | 0.392 | -0.392 | 0.392 |
| 237 | ILE | 241 | ILE | 0.969 | 0.580 | 0.389 | 0.389 |
| 250 | ILE | 254 | LYS | 0.476 | 0.852 | -0.376 | 0.376 |
| 29 | TRP | 312 | TYR | 0.000 | 0.375 | -0.375 | 0.375 |
| 91 | LYS | 172 | PRO | 1.145 | 0.770 | 0.375 | 0.375 |
| 153 | SER | 242 | ILE | 2.810 | 2.437 | 0.373 | 0.373 |
| 146 | ILE | 242 | ILE | 0.000 | 0.372 | -0.372 | 0.372 |
| 108 | VAL | 111 | THR | 0.000 | 0.371 | -0.371 | 0.371 |
| 231 | PHE | 236 | VAL | 5.274 | 5.642 | -0.368 | 0.368 |
| 156 | ARG | 269 | LEU | 0.000 | 0.364 | -0.364 | 0.364 |
| 84 | ILE | 99 | PHE | 2.774 | 2.412 | 0.362 | 0.362 |
| 139 | TYR | 226 | MET | 0.359 | 0.000 | 0.359 | 0.359 |
| 33 | TRP | 202 | ARG | 0.000 | 0.357 | -0.357 | 0.357 |
| 261 | GLY | 266 | ASP | 0.355 | 0.000 | 0.355 | 0.355 |
| 141 | ASN | 183 | TRP | 0.354 | 0.000 | 0.354 | 0.354 |
| 122 | ASN | 207 | VAL | 2.785 | 3.132 | -0.347 | 0.347 |
| 5 | ILE | 304 | HIS | 0.347 | 0.000 | 0.347 | 0.347 |
| 29 | TRP | 287 | TRP | 0.000 | 0.346 | -0.346 | 0.346 |
| 83 | VAL | 341 | PHE | 0.343 | 0.000 | 0.343 | 0.343 |
| 98 | ILE | 334 | ASP | 0.343 | 0.000 | 0.343 | 0.343 |
| 117 | THR | 121 | MET | 1.408 | 1.751 | -0.343 | 0.343 |
| 2 | ASP | 3 | SER | 0.336 | 0.000 | 0.336 | 0.336 |
| 296 | VAL | 302 | THR | 1.492 | 1.828 | -0.336 | 0.336 |
| 139 | TYR | 143 | PHE | 0.236 | 0.572 | -0.336 | 0.336 |
| 3 | SER | 4 | PRO | 0.595 | 0.931 | -0.335 | 0.335 |
| 161 | CYS | 248 | LEU | 1.281 | 0.949 | 0.332 | 0.332 |
| 135 | ILE | 211 | SER | 2.407 | 2.739 | -0.331 | 0.331 |
| 112 | MET | 317 | ALA | 0.329 | 0.000 | 0.329 | 0.329 |
| 98 | ILE | 331 | ALA | 0.328 | 0.000 | 0.328 | 0.328 |
| 21 | CYS | 22 | LEU | 0.326 | 0.000 | 0.326 | 0.326 |
| 153 | SER | 154 | VAL | 0.324 | 0.000 | 0.324 | 0.324 |
| 146 | ILE | 150 | THR | 0.182 | 0.506 | -0.324 | 0.324 |
| 104 | ALA | 144 | THR | 1.175 | 0.852 | 0.324 | 0.324 |
| 173 | LEU | 177 | ILE | 0.771 | 0.447 | 0.323 | 0.323 |
| 160 | VAL | 161 | CYS | 0.051 | 0.374 | -0.323 | 0.323 |
| 250 | ILE | 276 | VAL | 0.322 | 0.000 | 0.322 | 0.322 |
| 293 | PHE | 302 | THR | 0.010 | 0.331 | -0.321 | 0.321 |
| 103 | LEU | 107 | LEU | 0.724 | 0.405 | 0.319 | 0.319 |
| 326 | ASN | 331 | ALA | 0.318 | 0.000 | 0.318 | 0.318 |
| 222 | TRP | 225 | PHE | 0.875 | 0.558 | 0.317 | 0.317 |
| 131 | CYS | 198 | GLY | 2.202 | 2.517 | -0.315 | 0.315 |
| 295 | LEU | 299 | LEU | 0.000 | 0.314 | -0.314 | 0.314 |
| 306 | THR | 310 | SER | 0.000 | 0.314 | -0.314 | 0.314 |
| 158 | ILE | 165 | LYS | 0.038 | 0.350 | -0.312 | 0.312 |
| 366 | ASP | 368 | ALA | 0.000 | 0.311 | -0.311 | 0.311 |
| 200 | LYS | 216 | ASP | 0.992 | 0.683 | 0.309 | 0.309 |
| 156 | ARG | 273 | THR | 0.000 | 0.308 | -0.308 | 0.308 |
| 269 | LEU | 273 | THR | 0.428 | 0.121 | 0.307 | 0.307 |
| 92 | THR | 94 | THR | 0.614 | 0.308 | 0.306 | 0.306 |
| 253 | LEU | 272 | ILE | 0.306 | 0.000 | 0.306 | 0.306 |
| 157 | TYR | 162 | HIS | 4.424 | 4.727 | -0.303 | 0.303 |
| 289 | PRO | 318 | LEU | 0.589 | 0.288 | 0.302 | 0.302 |
| 135 | ILE | 197 | GLY | 0.099 | 0.400 | -0.302 | 0.302 |
| 100 | ASN | 182 | ILE | 0.000 | 0.301 | -0.301 | 0.301 |
| 144 | THR | 186 | SER | 5.245 | 4.945 | 0.300 | 0.300 |
| 58 | ILE | 310 | SER | 1.224 | 1.522 | -0.298 | 0.298 |
| 96 | ILE | 176 | LYS | 0.929 | 1.227 | -0.298 | 0.298 |
| 250 | ILE | 272 | ILE | 0.297 | 0.000 | 0.297 | 0.297 |
| 199 | THR | 208 | ILE | 0.908 | 1.203 | -0.295 | 0.295 |
| 238 | PRO | 283 | PHE | 0.287 | 0.000 | 0.287 | 0.287 |
| 286 | CYS | 315 | CYS | 0.132 | 0.418 | -0.286 | 0.286 |
| 79 | LEU | 82 | PHE | 0.000 | 0.284 | -0.284 | 0.284 |
| 79 | LEU | 83 | VAL | 0.231 | 0.513 | -0.281 | 0.281 |
| 97 | TYR | 155 | ASP | 1.016 | 0.736 | 0.280 | 0.280 |
| 201 | VAL | 206 | ASP | 0.000 | 0.276 | -0.276 | 0.276 |
| 84 | ILE | 91 | LYS | 0.000 | 0.275 | -0.275 | 0.275 |
| 143 | PHE | 233 | PHE | 0.654 | 0.928 | -0.273 | 0.273 |
| 112 | MET | 320 | TYR | 5.594 | 5.323 | 0.271 | 0.271 |
| 292 | ILE | 296 | VAL | 0.544 | 0.274 | 0.270 | 0.270 |
| 198 | GLY | 213 | GLN | 3.316 | 3.583 | -0.268 | 0.268 |
| 71 | VAL | 75 | VAL | 0.277 | 0.011 | 0.265 | 0.265 |
| 151 | MET | 178 | ILE | 1.491 | 1.756 | -0.265 | 0.265 |
| 20 | ALA | 21 | CYS | 0.264 | 0.000 | 0.264 | 0.264 |
| 305 | SER | 308 | ALA | 1.049 | 0.787 | 0.262 | 0.262 |
| 236 | VAL | 240 | LEU | 0.509 | 0.771 | -0.262 | 0.262 |
| 69 | VAL | 74 | LEU | 0.000 | 0.261 | -0.261 | 0.261 |
| 139 | TYR | 230 | VAL | 0.247 | 0.508 | -0.260 | 0.260 |
| 109 | THR | 324 | SER | 0.606 | 0.347 | 0.260 | 0.260 |
| 111 | THR | 115 | GLN | 0.000 | 0.259 | -0.259 | 0.259 |
| 325 | LEU | 329 | LEU | 0.259 | 0.000 | 0.259 | 0.259 |
| 196 | LEU | 212 | LEU | 2.681 | 2.939 | -0.258 | 0.258 |
| 55 | SER | 56 | PRO | 1.211 | 1.469 | -0.258 | 0.258 |
| 6 | GLN | 204 | ASP | 0.257 | 0.000 | 0.257 | 0.257 |
| 330 | TYR | 338 | LYS | 0.000 | 0.255 | -0.255 | 0.255 |
| 28 | ALA | 30 | PHE | 0.000 | 0.253 | -0.253 | 0.253 |
| 196 | LEU | 214 | PHE | 0.667 | 0.415 | 0.252 | 0.252 |
| 156 | ARG | 159 | ALA | 0.000 | 0.249 | -0.249 | 0.249 |
| 154 | VAL | 245 | CYS | 1.212 | 1.461 | -0.249 | 0.249 |
| 62 | ILE | 119 | TYR | 3.965 | 3.716 | 0.249 | 0.249 |
| 81 | MET | 102 | ALA | 1.177 | 1.422 | -0.245 | 0.245 |
| 329 | LEU | 334 | ASP | 0.000 | 0.245 | -0.245 | 0.245 |
| 32 | GLY | 202 | ARG | 0.000 | 0.244 | -0.244 | 0.244 |
| 108 | VAL | 112 | MET | 0.000 | 0.242 | -0.242 | 0.242 |
| 30 | PHE | 119 | TYR | 0.000 | 0.241 | -0.241 | 0.241 |
| 7 | ILE | 8 | PHE | 0.000 | 0.239 | -0.239 | 0.239 |
| 299 | LEU | 301 | SER | 0.000 | 0.238 | -0.238 | 0.238 |
| 197 | GLY | 211 | SER | 1.436 | 1.673 | -0.236 | 0.236 |
| 94 | THR | 334 | ASP | 0.235 | 0.000 | 0.235 | 0.235 |
| 80 | VAL | 332 | PHE | 0.235 | 0.000 | 0.235 | 0.235 |
| 128 | ASP | 198 | GLY | 2.289 | 2.056 | 0.234 | 0.234 |
| 239 | VAL | 284 | VAL | 0.226 | 0.459 | -0.232 | 0.232 |
| 132 | LYS | 193 | ALA | 0.228 | 0.000 | 0.228 | 0.228 |
| 30 | PHE | 124 | TRP | 0.000 | 0.226 | -0.226 | 0.226 |
| 150 | THR | 238 | PRO | 2.264 | 2.489 | -0.225 | 0.225 |
| 207 | VAL | 209 | GLU | 0.000 | 0.223 | -0.223 | 0.223 |
| 255 | SER | 256 | VAL | 0.223 | 0.000 | 0.223 | 0.223 |
| 25 | ASN | 27 | SER | 0.000 | 0.223 | -0.223 | 0.223 |
| 107 | LEU | 183 | TRP | 0.154 | 0.376 | -0.222 | 0.222 |
| 74 | LEU | 106 | ALA | 0.000 | 0.221 | -0.221 | 0.221 |
| 225 | PHE | 229 | CYS | 2.628 | 2.848 | -0.220 | 0.220 |
| 273 | THR | 277 | LEU | 0.220 | 0.000 | 0.220 | 0.220 |
| 227 | LYS | 294 | ILE | 1.758 | 1.978 | -0.219 | 0.219 |
| 271 | ARG | 333 | LEU | 0.219 | 0.000 | 0.219 | 0.219 |
| 161 | CYS | 162 | HIS | 1.200 | 1.419 | -0.218 | 0.218 |
| 219 | TYR | 223 | ASP | 0.463 | 0.245 | 0.218 | 0.218 |
| 235 | PHE | 284 | VAL | 0.003 | 0.220 | -0.217 | 0.217 |
| 124 | TRP | 208 | ILE | 6.286 | 6.503 | -0.216 | 0.216 |
| 294 | ILE | 312 | TYR | 0.216 | 0.000 | 0.216 | 0.216 |
| 78 | SER | 81 | MET | 0.065 | 0.280 | -0.215 | 0.215 |
| 185 | LEU | 188 | SER | 0.000 | 0.214 | -0.214 | 0.214 |
| 329 | LEU | 333 | LEU | 0.186 | 0.399 | -0.214 | 0.214 |
| 116 | SER | 120 | LEU | 0.213 | 0.000 | 0.213 | 0.213 |
| 147 | PHE | 233 | PHE | 1.175 | 0.962 | 0.213 | 0.213 |
| 378 | LYS | 379 | PRO | 0.076 | 0.283 | -0.207 | 0.207 |
| 200 | LYS | 209 | GLU | 6.119 | 6.325 | -0.206 | 0.206 |
| 171 | THR | 173 | LEU | 0.265 | 0.062 | 0.202 | 0.202 |
| 202 | ARG | 207 | VAL | 4.130 | 3.928 | 0.202 | 0.202 |
| 154 | VAL | 241 | ILE | 0.602 | 0.400 | 0.202 | 0.202 |
| 93 | ALA | 97 | TYR | 0.201 | 0.000 | 0.201 | 0.201 |
| 250 | ILE | 253 | LEU | 0.201 | 0.000 | 0.201 | 0.201 |
| 188 | SER | 189 | VAL | 0.371 | 0.571 | -0.200 | 0.200 |
| 286 | CYS | 287 | TRP | 0.080 | 0.276 | -0.196 | 0.196 |
| 139 | TYR | 190 | GLY | 0.000 | 0.195 | -0.195 | 0.195 |
| 76 | GLY | 341 | PHE | 0.000 | 0.194 | -0.194 | 0.194 |
| 80 | VAL | 341 | PHE | 0.000 | 0.194 | -0.194 | 0.194 |
| 254 | LYS | 260 | SER | 0.194 | 0.000 | 0.194 | 0.194 |
| 81 | MET | 103 | LEU | 2.086 | 2.280 | -0.194 | 0.194 |
| 297 | GLU | 312 | TYR | 0.193 | 0.000 | 0.193 | 0.193 |
| 249 | MET | 272 | ILE | 0.192 | 0.000 | 0.192 | 0.192 |
| 68 | VAL | 73 | GLY | 0.000 | 0.192 | -0.192 | 0.192 |
| 77 | ASN | 327 | PRO | 5.385 | 5.576 | -0.191 | 0.191 |
| 149 | LEU | 152 | MET | 0.000 | 0.191 | -0.191 | 0.191 |
| 69 | VAL | 317 | ALA | 0.190 | 0.000 | 0.190 | 0.190 |
| 117 | THR | 123 | SER | 0.080 | 0.267 | -0.187 | 0.187 |
| 32 | GLY | 209 | GLU | 0.000 | 0.186 | -0.186 | 0.186 |
| 16 | CYS | 17 | ALA | 0.000 | 0.186 | -0.186 | 0.186 |
| 232 | ILE | 237 | ILE | 5.295 | 5.481 | -0.186 | 0.186 |
| 65 | VAL | 66 | TYR | 0.000 | 0.182 | -0.182 | 0.182 |
| 58 | ILE | 62 | ILE | 0.730 | 0.910 | -0.180 | 0.180 |
| 112 | MET | 115 | GLN | 0.000 | 0.175 | -0.175 | 0.175 |
| 157 | TYR | 249 | MET | 0.137 | 0.309 | -0.173 | 0.173 |
| 135 | ILE | 198 | GLY | 0.000 | 0.172 | -0.172 | 0.172 |
| 110 | THR | 111 | THR | 0.171 | 0.000 | 0.171 | 0.171 |
| 94 | THR | 272 | ILE | 0.000 | 0.170 | -0.170 | 0.170 |
| 130 | LEU | 133 | ILE | 0.000 | 0.170 | -0.170 | 0.170 |
| 198 | GLY | 211 | SER | 5.665 | 5.495 | 0.169 | 0.169 |
| 305 | SER | 307 | ALA | 0.608 | 0.439 | 0.168 | 0.168 |
| 139 | TYR | 142 | MET | 0.168 | 0.000 | 0.168 | 0.168 |
| 58 | ILE | 59 | PRO | 1.118 | 1.285 | -0.167 | 0.167 |
| 99 | PHE | 103 | LEU | 0.171 | 0.004 | 0.167 | 0.167 |
| 184 | LEU | 187 | SER | 0.166 | 0.000 | 0.166 | 0.166 |
| 7 | ILE | 297 | GLU | 0.165 | 0.000 | 0.165 | 0.165 |
| 141 | ASN | 287 | TRP | 0.000 | 0.165 | -0.165 | 0.165 |
| 33 | TRP | 58 | ILE | 0.000 | 0.164 | -0.164 | 0.164 |
| 149 | LEU | 242 | ILE | 0.102 | 0.264 | -0.162 | 0.162 |
| 8 | PHE | 304 | HIS | 0.162 | 0.000 | 0.162 | 0.162 |
| 135 | ILE | 193 | ALA | 0.734 | 0.895 | -0.161 | 0.161 |
| 72 | VAL | 77 | ASN | 0.000 | 0.160 | -0.160 | 0.160 |
| 74 | LEU | 78 | SER | 0.373 | 0.533 | -0.160 | 0.160 |
| 80 | VAL | 84 | ILE | 0.743 | 0.583 | 0.160 | 0.160 |
| 73 | GLY | 323 | SER | 0.000 | 0.159 | -0.159 | 0.159 |
| 17 | ALA | 18 | PRO | 0.745 | 0.586 | 0.159 | 0.159 |
| 293 | PHE | 297 | GLU | 1.035 | 1.192 | -0.157 | 0.157 |
| 87 | TYR | 343 | ASP | 0.157 | 0.000 | 0.157 | 0.157 |
| 325 | LEU | 328 | ILE | 0.311 | 0.155 | 0.156 | 0.156 |
| 326 | ASN | 329 | LEU | 0.000 | 0.155 | -0.155 | 0.155 |
| 148 | THR | 152 | MET | 0.375 | 0.529 | -0.154 | 0.154 |
| 66 | TYR | 116 | SER | 3.160 | 3.314 | -0.154 | 0.154 |
| 198 | GLY | 209 | GLU | 0.513 | 0.665 | -0.152 | 0.152 |
| 68 | VAL | 72 | VAL | 0.305 | 0.456 | -0.151 | 0.151 |
| 54 | ILE | 58 | ILE | 1.416 | 1.266 | 0.150 | 0.150 |
| 234 | ALA | 283 | PHE | 0.322 | 0.471 | -0.150 | 0.150 |
| 230 | VAL | 235 | PHE | 0.420 | 0.569 | -0.149 | 0.149 |
| 147 | PHE | 186 | SER | 0.678 | 0.827 | -0.149 | 0.149 |
| 152 | MET | 156 | ARG | 0.149 | 0.000 | 0.149 | 0.149 |
| 160 | VAL | 273 | THR | 0.000 | 0.148 | -0.148 | 0.148 |
| 224 | LEU | 298 | ALA | 0.690 | 0.835 | -0.145 | 0.145 |
| 248 | LEU | 251 | LEU | 0.142 | 0.000 | 0.142 | 0.142 |
| 135 | ILE | 212 | LEU | 0.880 | 1.020 | -0.139 | 0.139 |
| 160 | VAL | 249 | MET | 2.773 | 2.635 | 0.139 | 0.139 |
| 334 | ASP | 335 | GLU | 0.139 | 0.000 | 0.139 | 0.139 |
| 27 | SER | 214 | PHE | 0.000 | 0.137 | -0.137 | 0.137 |
| 230 | VAL | 291 | HIS | 0.391 | 0.526 | -0.134 | 0.134 |
| 358 | SER | 359 | ARG | 0.134 | 0.000 | 0.134 | 0.134 |
| 282 | VAL | 322 | ASN | 1.048 | 1.182 | -0.134 | 0.134 |
| 63 | THR | 67 | SER | 0.103 | 0.236 | -0.132 | 0.132 |
| 144 | THR | 148 | THR | 0.280 | 0.411 | -0.131 | 0.131 |
| 98 | ILE | 337 | PHE | 0.000 | 0.129 | -0.129 | 0.129 |
| 197 | GLY | 212 | LEU | 1.463 | 1.335 | 0.128 | 0.128 |
| 192 | SER | 197 | GLY | 0.149 | 0.021 | 0.128 | 0.128 |
| 249 | MET | 253 | LEU | 0.413 | 0.540 | -0.127 | 0.127 |
| 179 | ASN | 182 | ILE | 0.290 | 0.417 | -0.127 | 0.127 |
| 241 | ILE | 245 | CYS | 0.543 | 0.417 | 0.126 | 0.126 |
| 274 | ARG | 278 | VAL | 0.000 | 0.126 | -0.126 | 0.126 |
| 77 | ASN | 326 | ASN | 0.000 | 0.124 | -0.124 | 0.124 |
| 276 | VAL | 280 | VAL | 0.014 | 0.136 | -0.122 | 0.122 |
| 178 | ILE | 182 | ILE | 0.416 | 0.538 | -0.122 | 0.122 |
| 284 | VAL | 288 | THR | 1.082 | 1.203 | -0.120 | 0.120 |
| 159 | ALA | 166 | ALA | 0.911 | 1.031 | -0.120 | 0.120 |
| 73 | GLY | 78 | SER | 0.000 | 0.118 | -0.118 | 0.118 |
| 108 | VAL | 109 | THR | 0.000 | 0.118 | -0.118 | 0.118 |
| 69 | VAL | 320 | TYR | 1.685 | 1.569 | 0.116 | 0.116 |
| 122 | ASN | 309 | LEU | 0.115 | 0.000 | 0.115 | 0.115 |
| 308 | ALA | 311 | SER | 0.114 | 0.000 | 0.114 | 0.114 |
| 209 | GLU | 211 | SER | 0.113 | 0.000 | 0.113 | 0.113 |
| 182 | ILE | 186 | SER | 0.195 | 0.308 | -0.112 | 0.112 |
| 127 | GLY | 199 | THR | 0.761 | 0.873 | -0.111 | 0.111 |
| 262 | SER | 264 | GLU | 0.108 | 0.000 | 0.108 | 0.108 |
| 278 | VAL | 282 | VAL | 0.255 | 0.149 | 0.106 | 0.106 |
| 91 | LYS | 96 | ILE | 0.000 | 0.106 | -0.106 | 0.106 |
| 225 | PHE | 226 | MET | 0.000 | 0.104 | -0.104 | 0.104 |
| 124 | TRP | 199 | THR | 1.363 | 1.466 | -0.103 | 0.103 |
| 293 | PHE | 315 | CYS | 0.101 | 0.000 | 0.101 | 0.101 |
| 229 | CYS | 234 | ALA | 0.025 | 0.126 | -0.101 | 0.101 |
| 142 | MET | 287 | TRP | 2.948 | 3.045 | -0.097 | 0.097 |
| 77 | ASN | 109 | THR | 0.096 | 0.000 | 0.096 | 0.096 |
| 187 | SER | 192 | SER | 0.000 | 0.096 | -0.096 | 0.096 |
| 26 | SER | 219 | TYR | 0.000 | 0.095 | -0.095 | 0.095 |
| 156 | ARG | 249 | MET | 1.206 | 1.300 | -0.094 | 0.094 |
| 120 | LEU | 121 | MET | 0.000 | 0.093 | -0.093 | 0.093 |
| 135 | ILE | 210 | CYS | 1.906 | 1.817 | 0.089 | 0.089 |
| 199 | THR | 209 | GLU | 3.320 | 3.231 | 0.088 | 0.088 |
| 263 | ARG | 270 | ARG | 0.340 | 0.428 | -0.088 | 0.088 |
| 332 | PHE | 333 | LEU | 0.000 | 0.088 | -0.088 | 0.088 |
| 98 | ILE | 152 | MET | 0.576 | 0.664 | -0.088 | 0.088 |
| 275 | LEU | 279 | VAL | 0.148 | 0.060 | 0.088 | 0.088 |
| 81 | MET | 106 | ALA | 0.560 | 0.474 | 0.086 | 0.086 |
| 280 | VAL | 284 | VAL | 0.227 | 0.142 | 0.085 | 0.085 |
| 134 | VAL | 138 | ASP | 0.000 | 0.085 | -0.085 | 0.085 |
| 117 | THR | 122 | ASN | 0.197 | 0.112 | 0.085 | 0.085 |
| 179 | ASN | 183 | TRP | 0.084 | 0.000 | 0.084 | 0.084 |
| 41 | SER | 42 | ALA | 0.000 | 0.083 | -0.083 | 0.083 |
| 233 | PHE | 238 | PRO | 2.864 | 2.947 | -0.083 | 0.083 |
| 228 | ILE | 232 | ILE | 0.790 | 0.873 | -0.083 | 0.083 |
| 361 | ARG | 365 | GLN | 0.000 | 0.082 | -0.082 | 0.082 |
| 110 | THR | 137 | ILE | 0.081 | 0.000 | 0.081 | 0.081 |
| 151 | MET | 155 | ASP | 0.000 | 0.081 | -0.081 | 0.081 |
| 321 | THR | 325 | LEU | 1.049 | 0.969 | 0.079 | 0.079 |
| 258 | LEU | 259 | LEU | 0.000 | 0.079 | -0.079 | 0.079 |
| 105 | ASP | 327 | PRO | 0.079 | 0.000 | 0.079 | 0.079 |
| 198 | GLY | 210 | CYS | 1.062 | 1.140 | -0.077 | 0.077 |
| 232 | ILE | 238 | PRO | 0.428 | 0.505 | -0.077 | 0.077 |
| 326 | ASN | 327 | PRO | 0.878 | 0.953 | -0.075 | 0.075 |
| 237 | ILE | 238 | PRO | 1.334 | 1.408 | -0.075 | 0.075 |
| 28 | ALA | 29 | TRP | 0.075 | 0.000 | 0.075 | 0.075 |
| 180 | ILE | 184 | LEU | 0.605 | 0.532 | 0.074 | 0.074 |
| 235 | PHE | 236 | VAL | 0.160 | 0.233 | -0.072 | 0.072 |
| 70 | PHE | 75 | VAL | 0.000 | 0.071 | -0.071 | 0.071 |
| 290 | ILE | 291 | HIS | 0.071 | 0.000 | 0.071 | 0.071 |
| 359 | ARG | 360 | VAL | 0.069 | 0.000 | 0.069 | 0.069 |
| 147 | PHE | 182 | ILE | 2.101 | 2.170 | -0.069 | 0.069 |
| 132 | LYS | 198 | GLY | 0.809 | 0.740 | 0.069 | 0.069 |
| 247 | THR | 251 | LEU | 0.406 | 0.339 | 0.067 | 0.067 |
| 360 | VAL | 363 | THR | 0.000 | 0.067 | -0.067 | 0.067 |
| 231 | PHE | 232 | ILE | 0.131 | 0.065 | 0.065 | 0.065 |
| 192 | SER | 196 | LEU | 0.000 | 0.065 | -0.065 | 0.065 |
| 59 | PRO | 120 | LEU | 0.322 | 0.387 | -0.065 | 0.065 |
| 61 | ILE | 65 | VAL | 0.008 | 0.072 | -0.065 | 0.065 |
| 115 | GLN | 316 | ILE | 0.064 | 0.000 | 0.064 | 0.064 |
| 67 | SER | 116 | SER | 0.000 | 0.063 | -0.063 | 0.063 |
| 283 | PHE | 288 | THR | 0.000 | 0.063 | -0.063 | 0.063 |
| 199 | THR | 210 | CYS | 0.091 | 0.030 | 0.061 | 0.061 |
| 57 | ALA | 61 | ILE | 0.303 | 0.243 | 0.060 | 0.060 |
| 53 | HIS | 306 | THR | 0.000 | 0.059 | -0.059 | 0.059 |
| 243 | ILE | 247 | THR | 0.476 | 0.417 | 0.059 | 0.059 |
| 65 | VAL | 317 | ALA | 0.352 | 0.294 | 0.058 | 0.058 |
| 140 | TYR | 145 | SER | 0.000 | 0.058 | -0.058 | 0.058 |
| 201 | VAL | 208 | ILE | 0.152 | 0.210 | -0.058 | 0.058 |
| 55 | SER | 58 | ILE | 0.000 | 0.058 | -0.058 | 0.058 |
| 358 | SER | 362 | ASN | 0.000 | 0.057 | -0.057 | 0.057 |
| 147 | PHE | 238 | PRO | 0.000 | 0.056 | -0.056 | 0.056 |
| 80 | VAL | 98 | ILE | 0.737 | 0.792 | -0.055 | 0.055 |
| 239 | VAL | 243 | ILE | 1.004 | 0.949 | 0.055 | 0.055 |
| 196 | LEU | 211 | SER | 0.353 | 0.408 | -0.055 | 0.055 |
| 131 | CYS | 135 | ILE | 0.908 | 0.854 | 0.054 | 0.054 |
| 200 | LYS | 208 | ILE | 1.702 | 1.650 | 0.051 | 0.051 |
| 162 | HIS | 165 | LYS | 0.930 | 0.980 | -0.051 | 0.051 |
| 124 | TRP | 125 | PRO | 0.272 | 0.322 | -0.050 | 0.050 |
| 154 | VAL | 158 | ILE | 0.805 | 0.755 | 0.050 | 0.050 |
| 129 | VAL | 133 | ILE | 0.507 | 0.458 | 0.049 | 0.049 |
| 70 | PHE | 71 | VAL | 0.394 | 0.345 | 0.049 | 0.049 |
| 63 | THR | 119 | TYR | 0.044 | 0.093 | -0.048 | 0.048 |
| 128 | ASP | 197 | GLY | 0.000 | 0.048 | -0.048 | 0.048 |
| 119 | TYR | 309 | LEU | 0.047 | 0.000 | 0.047 | 0.047 |
| 115 | GLN | 119 | TYR | 0.000 | 0.046 | -0.046 | 0.046 |
| 135 | ILE | 139 | TYR | 0.968 | 1.014 | -0.046 | 0.046 |
| 71 | VAL | 76 | GLY | 0.029 | 0.074 | -0.045 | 0.045 |
| 146 | ILE | 149 | LEU | 0.000 | 0.045 | -0.045 | 0.045 |
| 226 | MET | 227 | LYS | 0.044 | 0.000 | 0.044 | 0.044 |
| 93 | ALA | 172 | PRO | 0.030 | 0.073 | -0.043 | 0.043 |
| 288 | THR | 289 | PRO | 1.064 | 1.104 | -0.040 | 0.040 |
| 158 | ILE | 163 | PRO | 0.612 | 0.652 | -0.040 | 0.040 |
| 272 | ILE | 276 | VAL | 0.140 | 0.180 | -0.039 | 0.039 |
| 244 | VAL | 248 | LEU | 0.732 | 0.693 | 0.039 | 0.039 |
| 137 | ILE | 138 | ASP | 0.000 | 0.038 | -0.038 | 0.038 |
| 242 | ILE | 246 | TYR | 1.378 | 1.340 | 0.038 | 0.038 |
| 160 | VAL | 253 | LEU | 1.412 | 1.374 | 0.038 | 0.038 |
| 197 | GLY | 213 | GLN | 0.032 | 0.070 | -0.037 | 0.037 |
| 65 | VAL | 69 | VAL | 0.369 | 0.332 | 0.037 | 0.037 |
| 145 | SER | 283 | PHE | 0.000 | 0.036 | -0.036 | 0.036 |
| 253 | LEU | 256 | VAL | 0.000 | 0.036 | -0.036 | 0.036 |
| 167 | LEU | 168 | ASP | 0.000 | 0.036 | -0.036 | 0.036 |
| 230 | VAL | 234 | ALA | 0.261 | 0.226 | 0.035 | 0.035 |
| 191 | ILE | 195 | VAL | 0.081 | 0.114 | -0.033 | 0.033 |
| 99 | PHE | 100 | ASN | 0.033 | 0.000 | 0.033 | 0.033 |
| 200 | LYS | 207 | VAL | 0.585 | 0.618 | -0.033 | 0.033 |
| 94 | THR | 95 | ASN | 0.100 | 0.068 | 0.033 | 0.033 |
| 15 | THR | 16 | CYS | 0.000 | 0.032 | -0.032 | 0.032 |
| 23 | PRO | 24 | PRO | 0.826 | 0.795 | 0.032 | 0.032 |
| 221 | TRP | 222 | TRP | 8.063 | 8.033 | 0.031 | 0.031 |
| 171 | THR | 172 | PRO | 0.827 | 0.858 | -0.030 | 0.030 |
| 131 | CYS | 199 | THR | 1.265 | 1.296 | -0.030 | 0.030 |
| 109 | THR | 320 | TYR | 0.030 | 0.000 | 0.030 | 0.030 |
| 9 | ARG | 309 | LEU | 0.029 | 0.000 | 0.029 | 0.029 |
| 150 | THR | 241 | ILE | 1.693 | 1.665 | 0.028 | 0.028 |
| 193 | ALA | 212 | LEU | 1.365 | 1.392 | -0.028 | 0.028 |
| 309 | LEU | 312 | TYR | 0.000 | 0.027 | -0.027 | 0.027 |
| 161 | CYS | 249 | MET | 0.845 | 0.870 | -0.025 | 0.025 |
| 288 | THR | 292 | ILE | 1.218 | 1.193 | 0.025 | 0.025 |
| 354 | ARG | 357 | THR | 0.000 | 0.025 | -0.025 | 0.025 |
| 90 | MET | 99 | PHE | 0.025 | 0.000 | 0.025 | 0.025 |
| 231 | PHE | 291 | HIS | 2.803 | 2.828 | -0.024 | 0.024 |
| 92 | THR | 95 | ASN | 4.160 | 4.184 | -0.024 | 0.024 |
| 139 | TYR | 189 | VAL | 0.960 | 0.936 | 0.024 | 0.024 |
| 88 | THR | 91 | LYS | 0.000 | 0.024 | -0.024 | 0.024 |
| 334 | ASP | 336 | ASN | 3.505 | 3.482 | 0.023 | 0.023 |
| 242 | ILE | 283 | PHE | 0.023 | 0.000 | 0.023 | 0.023 |
| 218 | ASP | 221 | TRP | 0.000 | 0.023 | -0.023 | 0.023 |
| 282 | VAL | 286 | CYS | 0.396 | 0.418 | -0.022 | 0.022 |
| 82 | PHE | 83 | VAL | 0.076 | 0.099 | -0.022 | 0.022 |
| 228 | ILE | 295 | LEU | 0.022 | 0.000 | 0.022 | 0.022 |
| 196 | LEU | 213 | GLN | 7.395 | 7.416 | -0.021 | 0.021 |
| 112 | MET | 113 | PRO | 0.807 | 0.787 | 0.020 | 0.020 |
| 141 | ASN | 146 | ILE | 0.000 | 0.019 | -0.019 | 0.019 |
| 297 | GLU | 302 | THR | 3.449 | 3.469 | -0.019 | 0.019 |
| 316 | ILE | 320 | TYR | 1.655 | 1.673 | -0.019 | 0.019 |
| 284 | VAL | 289 | PRO | 0.241 | 0.223 | 0.018 | 0.018 |
| 104 | ALA | 183 | TRP | 0.000 | 0.018 | -0.018 | 0.018 |
| 302 | THR | 308 | ALA | 0.000 | 0.018 | -0.018 | 0.018 |
| 213 | GLN | 219 | TYR | 0.017 | 0.000 | 0.017 | 0.017 |
| 283 | PHE | 284 | VAL | 0.000 | 0.017 | -0.017 | 0.017 |
| 133 | ILE | 137 | ILE | 0.882 | 0.866 | 0.016 | 0.016 |
| 131 | CYS | 211 | SER | 0.450 | 0.466 | -0.016 | 0.016 |
| 157 | TYR | 158 | ILE | 0.398 | 0.383 | 0.015 | 0.015 |
| 158 | ILE | 162 | HIS | 0.107 | 0.092 | 0.015 | 0.015 |
| 162 | HIS | 163 | PRO | 0.094 | 0.108 | -0.014 | 0.014 |
| 287 | TRP | 290 | ILE | 0.468 | 0.480 | -0.013 | 0.013 |
| 97 | TYR | 152 | MET | 2.337 | 2.325 | 0.012 | 0.012 |
| 80 | VAL | 102 | ALA | 0.897 | 0.885 | 0.012 | 0.012 |
| 229 | CYS | 233 | PHE | 0.112 | 0.120 | -0.008 | 0.008 |
| 124 | TRP | 209 | GLU | 0.109 | 0.102 | 0.007 | 0.007 |
| 214 | PHE | 215 | PRO | 0.874 | 0.867 | 0.007 | 0.007 |
| 177 | ILE | 181 | CYS | 0.187 | 0.182 | 0.005 | 0.005 |
| 253 | LEU | 257 | ARG | 0.000 | 0.004 | -0.004 | 0.004 |
| 93 | ALA | 155 | ASP | 0.004 | 0.000 | 0.004 | 0.004 |
| 77 | ASN | 101 | LEU | 0.003 | 0.000 | 0.003 | 0.003 |
| 82 | PHE | 87 | TYR | 0.003 | 0.000 | 0.003 | 0.003 |
| 322 | ASN | 323 | SER | 0.000 | 0.001 | -0.001 | 0.001 |
| 91 | LYS | 92 | THR | 0.001 | 0.000 | 0.001 | 0.001 |
RRCS change distribution
-0.01
Mean ΔRRCS
1.84
Std Dev
-0.06
Median
Magnitude classification
27
High (|Δ| ≥ 5.0)
60
Medium (2.6 ≤ |Δ| < 5.0)
724
Low (|Δ| < 2.6)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.56, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar