OPRM
819
Total Contact Pairs
94
Significant Changes
13.90
Max Increase
-9.02
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | TYR98 (1.60x60) | PHE352 (8.57x57) | 13.902 | 0.000 | +13.902 | HIGH |
| 2 | LEU34 | GLU312 | 9.811 | 0.000 | +9.811 | HIGH |
| 3 | HIS36 | THR62 | 0.000 | 9.025 | -9.025 | HIGH |
| 4 | ARG167 (3.50x50) | THR281 (6.34x34) | 0.000 | 8.873 | -8.873 | HIGH |
| 5 | TYR254 (5.58x58) | LEU285 (6.38x38) | 0.000 | 8.863 | -8.863 | HIGH |
| 6 | SER27 | GLU231 (5.35x36) | 8.536 | 0.000 | +8.536 | HIGH |
| 7 | TYR77 (1.39x39) | HIS321 (7.36x35) | 8.227 | 0.000 | +8.227 | HIGH |
| 8 | TYR151 (3.34x34) | TRP194 (4.50x50) | 9.929 | 2.441 | +7.488 | HIGH |
| 9 | ARG167 (3.50x50) | LEU277 (6.30x30) | 0.000 | 7.255 | -7.255 | HIGH |
| 10 | HIS387 | GLN388 | 0.000 | 6.633 | -6.633 | HIGH |
| 11 | MET101 (12.50x50) | ASN106 (2.40x40) | 0.160 | 6.295 | -6.135 | HIGH |
| 12 | HIS36 | GLN214 | 6.033 | 0.000 | +6.033 | HIGH |
| 13 | GLU390 | ASN391 | 0.000 | 5.935 | -5.935 | HIGH |
| 14 | LEU118 (2.52x52) | ASN152 (3.35x35) | 5.736 | 0.000 | +5.736 | HIGH |
| 15 | ARG167 (3.50x50) | ILE280 (6.33x33) | 0.000 | 5.543 | -5.543 | HIGH |
| 16 | SER27 | THR227 (5.31x32) | 0.023 | 5.534 | -5.510 | HIGH |
| 17 | TRP31 | VAL302 (6.55x55) | 0.000 | 5.491 | -5.491 | HIGH |
| 18 | ASP274 (6.27x27) | ARG278 (6.31x31) | 1.415 | 6.884 | -5.468 | HIGH |
| 19 | ARG167 (3.50x50) | TYR254 (5.58x58) | 5.468 | 0.000 | +5.468 | HIGH |
| 20 | ALA339 (7.54x54) | PHE345 (8.50x50) | 5.426 | 0.069 | +5.356 | HIGH |
| 21 | LEU37 | GLN214 | 5.266 | 0.000 | +5.266 | HIGH |
| 22 | PRO28 | LYS235 (5.39x40) | 5.062 | 0.000 | +5.062 | HIGH |
| 23 | LEU341 (7.56x56) | LYS346 (8.51x51) | 4.935 | 0.000 | +4.935 | MED |
| 24 | VAL32 | ASP218 | 4.914 | 0.000 | +4.914 | MED |
| 25 | SER164 (3.47x47) | TYR254 (5.58x58) | 6.540 | 1.647 | +4.893 | MED |
| 26 | GLY29 | LEU221 (45.52x52) | 0.416 | 5.201 | -4.785 | MED |
| 27 | PRO28 | LEU34 | 0.000 | 4.630 | -4.630 | MED |
| 28 | GLU395 | THR396 | 0.000 | 4.572 | -4.572 | MED |
| 29 | PRO28 | GLU231 (5.35x36) | 7.315 | 2.765 | +4.550 | MED |
| 30 | ARG347 (8.52x52) | GLU351 (8.56x56) | 0.000 | 4.465 | -4.465 | MED |
| 31 | LEU123 (2.57x57) | TYR328 (7.43x42) | 7.643 | 3.230 | +4.413 | MED |
| 32 | THR385 | ASN386 | 0.044 | 4.456 | -4.411 | MED |
| 33 | MET101 (12.50x50) | PHE345 (8.50x50) | 0.000 | 4.322 | -4.322 | MED |
| 34 | MET266 | LYS273 (6.26x26) | 4.219 | 0.000 | +4.219 | MED |
| 35 | TYR108 (2.42x42) | ASN190 (4.46x46) | 6.913 | 2.711 | +4.202 | MED |
| 36 | PRO335 (7.50x50) | PHE340 (7.55x55) | 4.193 | 0.000 | +4.193 | MED |
| 37 | ILE73 (1.35x35) | TYR130 (2.64x64) | 4.644 | 0.555 | +4.089 | MED |
| 38 | ILE169 (3.52x52) | PHE180 (34.56x56) | 4.074 | 0.000 | +4.074 | MED |
| 39 | MET92 (1.54x54) | PHE110 (2.44x44) | 2.850 | 6.788 | -3.939 | MED |
| 40 | LEU267 | ASP274 (6.27x27) | 1.691 | 5.623 | -3.932 | MED |
| 41 | TRP31 | TYR150 (3.33x33) | 0.000 | 3.927 | -3.927 | MED |
| 42 | TRP31 | ASN129 (2.63x63) | 3.920 | 0.000 | +3.920 | MED |
| 43 | LEU90 (1.52x52) | PHE349 (8.54x54) | 0.000 | 3.897 | -3.897 | MED |
| 44 | VAL32 | TYR130 (2.64x64) | 0.000 | 3.882 | -3.882 | MED |
| 45 | THR155 (3.38x38) | ASN193 (4.49x49) | 0.000 | 3.874 | -3.874 | MED |
| 46 | PHE125 (2.59x59) | PHE137 (23.52x52) | 2.916 | 6.764 | -3.848 | MED |
| 47 | VAL336 (7.51x51) | LEU341 (7.56x56) | 3.750 | 0.000 | +3.750 | MED |
| 48 | PHE158 (3.41x41) | ASN193 (4.49x49) | 2.251 | 5.953 | -3.702 | MED |
| 49 | PHE223 | GLU231 (5.35x36) | 8.093 | 4.405 | +3.689 | MED |
| 50 | TYR301 (6.54x54) | TRP320 (7.35x34) | 4.223 | 7.870 | -3.647 | MED |
| 51 | TYR151 (3.34x34) | SER197 (4.53x53) | 7.159 | 3.554 | +3.606 | MED |
| 52 | THR162 (3.45x45) | ASN193 (4.49x49) | 3.593 | 0.000 | +3.593 | MED |
| 53 | TYR151 (3.34x34) | SER198 (4.54x54) | 3.712 | 7.268 | -3.556 | MED |
| 54 | ASP116 (2.50x50) | SER156 (3.39x39) | 3.633 | 0.105 | +3.528 | MED |
| 55 | LEU267 | LYS273 (6.26x26) | 3.516 | 0.000 | +3.516 | MED |
| 56 | HIS36 | GLY63 | 0.000 | 3.464 | -3.464 | MED |
| 57 | TYR168 (3.51x51) | MET257 (5.61x61) | 0.148 | 3.572 | -3.424 | MED |
| 58 | TYR77 (1.39x39) | LEU123 (2.57x57) | 1.042 | 4.460 | -3.419 | MED |
| 59 | ILE109 (2.43x43) | TYR338 (7.53x53) | 1.223 | 4.585 | -3.362 | MED |
| 60 | ASP166 (3.49x49) | ARG181 (34.57x57) | 7.733 | 11.093 | -3.360 | MED |
| 61 | ASP383 | ARG384 | 0.000 | 3.345 | -3.345 | MED |
| 62 | LEU90 (1.52x52) | PHE352 (8.57x57) | 0.000 | 3.318 | -3.318 | MED |
| 63 | ALA339 (7.54x54) | LYS346 (8.51x51) | 0.000 | 3.316 | -3.316 | MED |
| 64 | THR99 (12.48x48) | ASN106 (2.40x40) | 3.263 | 0.000 | +3.263 | MED |
| 65 | TYR150 (3.33x33) | VAL204 (4.60x60) | 1.285 | 4.524 | -3.239 | MED |
| 66 | PHE340 (7.55x55) | LYS346 (8.51x51) | 3.203 | 0.000 | +3.203 | MED |
| 67 | LYS211 | THR222 | 3.144 | 0.000 | +3.144 | MED |
| 68 | TYR168 (3.51x51) | CYS253 (5.57x57) | 4.409 | 1.268 | +3.141 | MED |
| 69 | ARG167 (3.50x50) | TYR338 (7.53x53) | 3.121 | 0.000 | +3.121 | MED |
| 70 | LEU34 | LYS305 (6.58x58) | 0.000 | 3.102 | -3.102 | MED |
| 71 | THR50 | ASP51 | 3.833 | 0.817 | +3.016 | MED |
| 72 | TYR151 (3.34x34) | GLY201 | 0.604 | 3.602 | -2.998 | MED |
| 73 | LEU160 | TYR338 (7.53x53) | 2.991 | 0.000 | +2.991 | MED |
| 74 | SER35 | GLY63 | 1.661 | 4.646 | -2.984 | MED |
| 75 | PHE154 | ILE200 | 2.461 | 5.428 | -2.967 | MED |
| 76 | GLU272 | ASN276 | 0.556 | 3.512 | -2.956 | MED |
| 77 | SER224 | TRP230 | 4.762 | 7.710 | -2.948 | MED |
| 78 | PHE322 | LEU326 | 2.933 | 0.000 | +2.933 | MED |
| 79 | PHE180 (34.56x56) | ASN185 | 6.926 | 4.008 | +2.917 | MED |
| 80 | PHE291 | ASN330 | 1.382 | 4.189 | -2.807 | MED |
| 81 | ILE298 | CYS323 | 4.584 | 1.782 | +2.802 | MED |
| 82 | ILE157 | TRP295 | 2.798 | 0.000 | +2.798 | MED |
| 83 | TYR77 (1.39x39) | ILE324 | 3.817 | 1.070 | +2.747 | MED |
| 84 | THR159 | ASN193 (4.49x49) | 0.519 | 3.244 | -2.725 | MED |
| 85 | TYR254 (5.58x58) | MET257 (5.61x61) | 1.043 | 3.757 | -2.715 | MED |
| 86 | TRP295 | GLY327 | 1.904 | 4.611 | -2.706 | MED |
| 87 | ASN185 | ILE189 | 2.694 | 0.000 | +2.694 | MED |
| 88 | THR182 | ASN185 | 1.145 | 3.833 | -2.688 | MED |
| 89 | ILE250 | PHE291 | 2.662 | 0.000 | +2.662 | MED |
| 90 | VAL96 | LYS102 | 0.000 | 2.649 | -2.649 | MED |
| 91 | TYR98 (1.60x60) | GLU351 (8.56x56) | 0.000 | 2.647 | -2.647 | MED |
| 92 | THR122 | ASP149 | 3.310 | 0.730 | +2.580 | MED |
| 93 | ASN111 | THR159 | 0.242 | 2.818 | -2.575 | MED |
| 94 | GLU343 | LYS346 (8.51x51) | 3.890 | 1.367 | +2.523 | MED |
| 95 | ASN33 | SER35 | 2.486 | 0.000 | +2.486 | LOW |
| 96 | GLU272 | ARG275 | 6.393 | 3.940 | +2.452 | LOW |
| 97 | ILE95 | LYS100 | 2.412 | 0.000 | +2.412 | LOW |
| 98 | THR155 (3.38x38) | TRP194 (4.50x50) | 6.366 | 3.966 | +2.400 | LOW |
| 99 | SER30 | ARG213 | 2.397 | 0.000 | +2.397 | LOW |
| 100 | TRP135 | CYS219 | 6.068 | 3.671 | +2.397 | LOW |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.52 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 73-98 | 98 (13.9), 77 (8.2), 73 (4.1) | 3 | 92 (-3.9), 90 (-3.9) | 2 |
| TM2 | 106-130 | 118 (5.7), 123 (4.4), 108 (4.2), 130 (4.1), 129 (3.9), 116 (3.5) | 6 | 106 (-6.1), 110 (-3.9), 125 (-3.8), 109 (-3.4) | 4 |
| TM3 | 150-169 | 151 (7.5), 152 (5.7), 164 (4.9), 169 (4.1), 162 (3.6), 156 (3.5) | 6 | 167 (-8.9), 150 (-3.9), 155 (-3.9), 158 (-3.7), 168 (-3.4), 166 (-3.4) | 6 |
| TM4 | 190-204 | 194 (7.5), 190 (4.2), 197 (3.6) | 3 | 193 (-3.9), 198 (-3.6), 204 (-3.2) | 3 |
| TM5 | 227-257 | 231 (8.5), 235 (5.1), 253 (3.1) | 3 | 254 (-8.9), 227 (-5.5), 257 (-3.4) | 3 |
| TM6 | 273-305 | 273 (4.2) | 1 | 281 (-8.9), 285 (-8.9), 277 (-7.3), 280 (-5.5), 302 (-5.5), 274 (-5.5), 278 (-5.5), 301 (-3.6), 305 (-3.1) | 9 |
| TM7 | 320-341 | 321 (8.2), 339 (5.4), 341 (4.9), 328 (4.4), 335 (4.2), 340 (4.2), 336 (3.8) | 7 | 320 (-3.6), 338 (-3.4) | 2 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 99-101 | 99 (3.3) | 1 | 101 (-6.1) | 1 |
| ICL2 | 180-181 | 180 (4.1) | 1 | 181 (-3.4) | 1 |
| ICL3 | 266-267 | 266 (4.2) | 1 | 267 (-3.9) | 1 |
| ECL1 | 137-137 | - | 0 | 137 (-3.8) | 1 |
| ECL2 | 211-223 | 214 (6.0), 218 (4.9), 223 (3.7), 211 (3.1), 222 (3.1) | 5 | 221 (-4.8) | 1 |
| ECL3 | 312-312 | 312 (9.8) | 1 | - | 0 |
| H8 | 345-352 | 352 (13.9), 345 (5.4), 346 (4.9) | 3 | 347 (-4.5), 351 (-4.5), 349 (-3.9) | 3 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
199 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 352 | p.Phe352Leu | c.1054T>C | 6.84e-07 | 1 / 0 | 13.90 | 0.973 | PATHOGENIC | 0.94 | |
| 98 | p.Tyr98Cys | c.293A>G | 3.09e-05 | 45 / 0 | 13.90 | 0.858 | PATHOGENIC | 1.00 | rs373741336 |
| 34 | p.Glu34Lys | c.100G>A | 7.15e-07 | 1 / 0 | 9.81 | 0.169 | BENIGN | 0.34 | |
| 34 | p.Glu34Val | c.101A>T | 7.15e-07 | 1 / 0 | 9.81 | - | nan | - | |
| 34 | p.Glu34Asp | c.102A>C | 1.36e-05 | 19 / 0 | 9.81 | - | nan | - | |
| 34 | p.Glu34Asp | c.102A>T | 7.15e-07 | 1 / 0 | 9.81 | - | nan | - | |
| 34 | p.Lys34Arg | c.101A>G | 7.14e-07 | 1 / 0 | 9.81 | - | nan | - | rs1251854747 |
| 34 | p.Lys34Asn | c.102G>C | 7.14e-07 | 1 / 0 | 9.81 | - | nan | - | rs1484361892 |
| 36 | p.Arg36Cys | c.106C>T | 1.36e-05 | 19 / 0 | 9.02 | 0.205 | BENIGN | 0.36 | rs200293056 |
| 62 | p.Thr62Ala | c.184A>G | 1.37e-06 | 2 / 0 | 9.02 | 0.058 | BENIGN | 0.38 | rs201013311 |
| 36 | p.Arg36Gly | c.106C>G | 1.29e-05 | 18 / 0 | 9.02 | - | nan | - | rs200293056 |
| 36 | p.Arg36Leu | c.107G>T | 2.86e-06 | 4 / 0 | 9.02 | - | nan | - | rs577434238 |
| 36 | p.Arg36His | c.107G>A | 1.43e-06 | 2 / 0 | 9.02 | - | nan | - | rs577434238 |
| 36 | p.Ala36Val | c.107C>T | 7.14e-07 | 1 / 0 | 9.02 | - | nan | - | rs1779567081 |
| 36 | p.Ala36Glu | c.107C>A | 7.14e-07 | 1 / 0 | 9.02 | - | nan | - | |
| 62 | p.Thr62Pro | c.184A>C | 3.57e-05 | 52 / 0 | 9.02 | - | nan | - | rs201013311 |
| 62 | p.Thr62Asn | c.185C>A | 2.06e-06 | 3 / 0 | 9.02 | - | nan | - | rs1297476429 |
| 36 | p.His36Tyr | c.106C>T | 4.38e-05 | 62 / 1 | 9.02 | - | nan | - | rs199953844 |
| 36 | p.His36Asn | c.106C>A | 1.37e-06 | 2 / 0 | 9.02 | - | nan | - | rs199953844 |
| 62 | p.Thr62Ser | c.185C>G | 2.06e-06 | 3 / 0 | 9.02 | - | nan | - | rs771201043 |
| 167 | p.Arg167Pro | c.500G>C | 6.58e-06 | 1 / 0 | 8.87 | 1.000 | PATHOGENIC | 1.00 | rs766402253 |
| 167 | p.Arg167Gln | c.500G>A | 6.84e-06 | 10 / 0 | 8.87 | - | nan | - | rs766402253 |
| 254 | p.Tyr254His | c.760T>C | 1.37e-06 | 2 / 0 | 8.86 | 0.994 | PATHOGENIC | 1.00 | rs1290858635 |
| 254 | p.Tyr254Asp | c.760T>G | 6.84e-07 | 1 / 0 | 8.86 | - | nan | - | |
| 254 | p.Tyr254Cys | c.761A>G | 3.42e-06 | 5 / 0 | 8.86 | - | nan | - | rs758020420 |
| 27 | p.Pro27Ala | c.79C>G | 7.15e-07 | 1 / 0 | 8.54 | 0.072 | BENIGN | 0.53 | |
| 27 | p.Pro27Ser | c.79C>T | 1.43e-06 | 2 / 0 | 8.54 | - | nan | - | |
| 27 | p.Pro27Thr | c.79C>A | 3.57e-06 | 5 / 0 | 8.54 | - | nan | - | rs755233900 |
| 27 | p.Gln27Lys | c.79C>A | 4.29e-06 | 6 / 0 | 8.54 | - | nan | - | rs1328682380 |
| 27 | p.Gln27Arg | c.80A>G | 1.43e-06 | 2 / 0 | 8.54 | - | nan | - | rs1033909721 |
| 27 | p.Ser27Ile | c.80G>T | 2.74e-06 | 4 / 0 | 8.54 | - | nan | - | rs780726314 |
| 27 | p.Ser27Arg | c.81C>A | 6.84e-07 | 1 / 0 | 8.54 | - | nan | - | |
| 77 | p.Tyr77Cys | c.230A>G | 1.38e-06 | 2 / 0 | 8.23 | 0.976 | PATHOGENIC | 0.99 | rs937906502 |
| 321 | p.His321Tyr | c.961C>T | 6.84e-07 | 1 / 0 | 8.23 | 0.510 | AMBIGUOUS | 0.75 | |
| 77 | p.Tyr77Ser | c.230A>C | 2.55e-05 | 37 / 0 | 8.23 | - | nan | - | rs937906502 |
| 321 | p.His321Asn | c.961C>A | 6.84e-07 | 1 / 0 | 8.23 | - | nan | - | |
| 321 | p.His321Pro | c.962A>C | 6.84e-07 | 1 / 0 | 8.23 | - | nan | - | |
| 321 | p.His321Gln | c.963C>A | 6.84e-07 | 1 / 0 | 8.23 | - | nan | - | |
| 194 | p.Trp194Cys | c.582G>T | 2.05e-06 | 3 / 0 | 7.49 | 0.998 | PATHOGENIC | 1.00 | rs201858274 |
| 151 | p.Tyr151Cys | c.452A>G | 1.37e-06 | 2 / 0 | 7.49 | 0.865 | PATHOGENIC | 1.00 | |
| 277 | p.Leu277Pro | c.830T>C | 6.16e-06 | 9 / 0 | 7.26 | 0.998 | PATHOGENIC | 0.94 | rs763655185 |
| 277 | p.Leu277Arg | c.830T>G | 6.84e-07 | 1 / 0 | 7.26 | - | nan | - | |
| 388 | p.Gln388His | c.1164G>C | 1.37e-06 | 2 / 0 | 6.63 | 0.120 | BENIGN | 0.81 | |
| 387 | p.His387Tyr | c.1159C>T | 6.86e-07 | 1 / 0 | 6.63 | 0.089 | BENIGN | 0.61 | |
| 214 | p.Gln214Arg | c.641A>G | 6.89e-07 | 1 / 0 | 6.03 | 0.073 | BENIGN | 0.42 | |
| 390 | p.Arg390Cys | c.1168C>T | 3.41e-04 | 492 / 2 | 5.94 | 0.497 | AMBIGUOUS | 0.57 | rs79668187 |
| 391 | p.Ser391Gly | c.1171A>G | 2.06e-06 | 3 / 0 | 5.94 | 0.140 | BENIGN | 0.49 | rs1792197377 |
| 391 | p.Ser391Thr | c.1172G>C | 6.88e-07 | 1 / 0 | 5.94 | - | nan | - | rs762824513 |
| 390 | p.Leu390Pro | c.1169T>C | 6.85e-07 | 1 / 0 | 5.94 | - | nan | - | |
| 391 | p.Pro391Leu | c.1172C>T | 6.85e-07 | 1 / 0 | 5.94 | - | nan | - | |
| 390 | p.Glu390Lys | c.1168G>A | 1.77e-06 | 1 / 0 | 5.94 | - | nan | - | rs1326523267 |
| 390 | p.Glu390Gly | c.1169A>G | 2.65e-05 | 15 / 0 | 5.94 | - | nan | - | rs758348717 |
| 391 | p.Leu391Val | c.1171T>G | 1.77e-06 | 1 / 0 | 5.94 | - | nan | - | |
| 391 | p.Leu391Phe | c.1173G>C | 1.77e-06 | 1 / 0 | 5.94 | - | nan | - | rs1193804794 |
| 390 | p.Pro390Ser | c.1168C>T | 1.77e-06 | 1 / 0 | 5.94 | - | nan | - | |
| 390 | p.Ile390Thr | c.1169T>C | 1.80e-05 | 23 / 0 | 5.94 | - | nan | - | rs780125425 |
| 391 | p.Asn391Asp | c.1171A>G | 6.57e-06 | 1 / 0 | 5.94 | - | nan | - | rs1797127592 |
| 390 | p.Pro390Leu | c.1169C>T | 6.84e-07 | 1 / 0 | 5.94 | - | nan | - | rs373281207 |
| 390 | p.Pro390Arg | c.1169C>G | 9.58e-06 | 14 / 0 | 5.94 | - | nan | - | rs373281207 |
| 152 | p.Asn152Asp | c.454A>G | 3.14e-04 | 453 / 3 | 5.74 | 0.991 | PATHOGENIC | 1.00 | rs17174801 |
| 280 | p.Ile280Val | c.838A>G | 6.84e-07 | 1 / 0 | 5.54 | 0.816 | PATHOGENIC | 1.00 | |
| 227 | p.Thr227Ala | c.679A>G | 1.71e-05 | 25 / 0 | 5.51 | 0.054 | BENIGN | 0.41 | rs201874618 |
| 302 | p.Val302Ile | c.904G>A | 3.15e-05 | 46 / 0 | 5.49 | 0.154 | BENIGN | 0.81 | rs187512719 |
| 31 | p.Pro31Leu | c.92C>T | 1.43e-06 | 2 / 0 | 5.49 | 0.117 | BENIGN | 0.53 | |
| 31 | p.Gln31Glu | c.91C>G | 2.86e-06 | 4 / 0 | 5.49 | - | nan | - | |
| 31 | p.Trp31Arg | c.91T>A | 1.37e-06 | 2 / 0 | 5.49 | - | nan | - | rs1423291779 |
| 302 | p.Val302Ala | c.905T>C | 6.84e-07 | 1 / 0 | 5.49 | - | nan | - | rs202213165 |
| 274 | p.Asp274Asn | c.820G>A | 2.83e-04 | 414 / 0 | 5.47 | 0.952 | PATHOGENIC | 0.99 | rs17174829 |
| 278 | p.Arg278Gln | c.833G>A | 1.09e-05 | 16 / 0 | 5.47 | 0.488 | AMBIGUOUS | 1.00 | rs201847839 |
| 274 | p.Asp274Gly | c.821A>G | 6.84e-07 | 1 / 0 | 5.47 | - | nan | - | |
| 274 | p.Asp274Glu | c.822C>G | 6.84e-07 | 1 / 0 | 5.47 | - | nan | - | |
| 278 | p.Arg278Leu | c.833G>T | 6.84e-07 | 1 / 0 | 5.47 | - | nan | - | rs201847839 |
| 339 | p.Ala339Glu | c.1016C>A | 6.84e-07 | 1 / 0 | 5.36 | 0.999 | PATHOGENIC | 0.85 | |
| 37 | p.Met37Val | c.109A>G | 2.14e-06 | 3 / 0 | 5.27 | 0.067 | BENIGN | 0.42 | rs1779528860 |
| 37 | p.Met37Leu | c.109A>T | 7.15e-07 | 1 / 0 | 5.27 | - | nan | - | |
| 37 | p.Met37Leu | c.109A>C | 6.58e-06 | 1 / 0 | 5.27 | - | nan | - | rs1779528860 |
| 37 | p.Met37Lys | c.110T>A | 7.15e-07 | 1 / 0 | 5.27 | - | nan | - | rs201734461 |
| 37 | p.Met37Thr | c.110T>C | 4.14e-05 | 58 / 0 | 5.27 | - | nan | - | rs201734461 |
| 37 | p.Met37Arg | c.110T>G | 1.43e-06 | 2 / 0 | 5.27 | - | nan | - | |
| 37 | p.Met37Ile | c.111G>A | 7.15e-07 | 1 / 0 | 5.27 | - | nan | - | |
| 37 | p.Met37Ile | c.111G>C | 2.86e-06 | 4 / 0 | 5.27 | - | nan | - | rs758842824 |
| 37 | p.Ala37Thr | c.109G>A | 6.56e-06 | 1 / 0 | 5.27 | - | nan | - | rs571366137 |
| 37 | p.Ala37Ser | c.109G>T | 1.43e-06 | 2 / 0 | 5.27 | - | nan | - | rs571366137 |
| 37 | p.Ala37Val | c.110C>T | 1.43e-06 | 2 / 0 | 5.27 | - | nan | - | |
| 37 | p.Leu37Ser | c.110T>C | 6.84e-07 | 1 / 0 | 5.27 | - | nan | - | |
| 37 | p.Leu37Phe | c.111A>C | 6.57e-06 | 1 / 0 | 5.27 | - | nan | - | rs1779622178 |
| 235 | p.Lys235Met | c.704A>T | 2.05e-06 | 3 / 0 | 5.06 | 0.931 | PATHOGENIC | 0.99 | rs767947264 |
| 28 | p.Pro28Ser | c.82C>T | 2.14e-06 | 3 / 0 | 5.06 | 0.069 | BENIGN | 0.47 | rs1779523625 |
| 28 | p.Pro28Ala | c.82C>G | 7.15e-07 | 1 / 0 | 5.06 | - | nan | - | |
| 28 | p.Pro28Leu | c.83C>T | 6.57e-06 | 1 / 0 | 5.06 | - | nan | - | rs929536552 |
| 28 | p.Pro28Ala | c.82C>G | 1.37e-06 | 2 / 0 | 5.06 | - | nan | - | rs1207812281 |
| 235 | p.Lys235Arg | c.704A>G | 2.05e-06 | 3 / 0 | 5.06 | - | nan | - | rs767947264 |
| 235 | p.Lys235Asn | c.705G>T | 6.84e-07 | 1 / 0 | 5.06 | - | nan | - | rs750834795 |
| 341 | p.Leu341Pro | c.1022T>C | 6.84e-07 | 1 / 0 | 4.94 | 0.998 | PATHOGENIC | 0.97 | |
| 346 | p.Lys346Glu | c.1036A>G | 4.10e-06 | 6 / 0 | 4.94 | 0.985 | PATHOGENIC | 1.00 | rs771106503 |
| 32 | p.Ala32Gly | c.95C>G | 6.57e-06 | 1 / 0 | 4.91 | 0.067 | BENIGN | 0.41 | rs1049355494 |
| 32 | p.Arg32Trp | c.94C>T | 7.14e-07 | 1 / 0 | 4.91 | - | nan | - | |
| 32 | p.Arg32Gln | c.95G>A | 7.14e-07 | 1 / 0 | 4.91 | - | nan | - | |
| 32 | p.Val32Leu | c.94G>C | 4.79e-06 | 7 / 0 | 4.91 | - | nan | - | rs1160067850 |
| 32 | p.Val32Ala | c.95T>C | 1.37e-06 | 2 / 0 | 4.91 | - | nan | - | |
| 164 | p.Ser164Arg | c.492T>G | 6.84e-07 | 1 / 0 | 4.89 | 1.000 | PATHOGENIC | 1.00 | |
| 29 | p.Leu29Val | c.85C>G | 7.15e-07 | 1 / 0 | 4.78 | 0.098 | BENIGN | 0.58 | |
| 29 | p.Gly29Cys | c.85G>T | 1.37e-06 | 2 / 0 | 4.78 | - | nan | - | rs775097209 |
| 395 | p.Leu395Pro | c.1184T>C | 6.84e-07 | 1 / 0 | 4.57 | 0.183 | BENIGN | 0.57 | |
| 396 | p.Ser396Tyr | c.1187C>A | 6.84e-07 | 1 / 0 | 4.57 | 0.145 | BENIGN | 0.58 | |
| 395 | p.Cys395Arg | c.1183T>C | 1.77e-06 | 1 / 0 | 4.57 | - | nan | - | |
| 395 | p.Cys395Tyr | c.1184G>A | 1.77e-06 | 1 / 0 | 4.57 | - | nan | - | rs1431508236 |
| 396 | p.His396Asn | c.1186C>A | 3.36e-05 | 19 / 0 | 4.57 | - | nan | - | rs1373802399 |
| 395 | p.Val395Ile | c.1183G>A | 1.97e-05 | 3 / 0 | 4.57 | - | nan | - | rs1414361004 |
| 395 | p.Val395Ala | c.1184T>C | 6.57e-06 | 1 / 0 | 4.57 | - | nan | - | rs1795813900 |
| 396 | p.Ala396Thr | c.1186G>A | 6.58e-06 | 1 / 0 | 4.57 | - | nan | - | rs1355692530 |
| 396 | p.Ala396Val | c.1187C>T | 6.57e-06 | 1 / 0 | 4.57 | - | nan | - | rs1357614491 |
| 396 | p.Asp396Tyr | c.1186G>T | 7.85e-06 | 4 / 0 | 4.57 | - | nan | - | |
| 396 | p.Ser396Leu | c.1187C>T | 7.47e-07 | 1 / 0 | 4.57 | - | nan | - | |
| 395 | p.Glu395Val | c.1184A>T | 6.84e-07 | 1 / 0 | 4.57 | - | nan | - | |
| 396 | p.Thr396Ala | c.1186A>G | 2.05e-06 | 3 / 0 | 4.57 | - | nan | - | rs201921259 |
| 396 | p.Thr396Ser | c.1187C>G | 6.84e-07 | 1 / 0 | 4.57 | - | nan | - | rs200398791 |
| 396 | p.Thr396Ile | c.1187C>T | 6.84e-06 | 10 / 0 | 4.57 | - | nan | - | rs200398791 |
| 395 | p.Met395Thr | c.1184T>C | 1.37e-06 | 2 / 0 | 4.57 | - | nan | - | |
| 395 | p.Met395Ile | c.1185G>T | 6.84e-07 | 1 / 0 | 4.57 | - | nan | - | |
| 396 | p.Ala396Pro | c.1186G>C | 1.37e-06 | 2 / 0 | 4.57 | - | nan | - | |
| 396 | p.Ala396Thr | c.1186G>A | 6.84e-07 | 1 / 0 | 4.57 | - | nan | - | |
| 351 | p.Glu351Lys | c.1051G>A | 6.84e-07 | 1 / 0 | 4.46 | 0.710 | PATHOGENIC | 0.77 | rs1259264846 |
| 347 | p.Arg347Gly | c.1039C>G | 6.57e-06 | 1 / 0 | 4.46 | 0.592 | PATHOGENIC | 0.98 | rs200512398 |
| 347 | p.Arg347Gln | c.1040G>A | 1.04e-04 | 152 / 0 | 4.46 | - | nan | - | rs77013544 |
| 386 | p.Asn386Asp | c.1156A>G | 1.37e-06 | 2 / 0 | 4.41 | 0.123 | BENIGN | 0.80 | rs2128487104 |
| 385 | p.Thr385Asn | c.1154C>A | 6.85e-07 | 1 / 0 | 4.41 | 0.087 | BENIGN | 0.62 | rs1347406881 |
| 386 | p.Asn386Lys | c.1158T>G | 6.86e-07 | 1 / 0 | 4.41 | - | nan | - | rs776230437 |
| 266 | p.Met266Val | c.796A>G | 1.37e-06 | 2 / 0 | 4.22 | 0.258 | BENIGN | 0.77 | rs1792047615 |
| 266 | p.Met266Thr | c.797T>C | 6.84e-07 | 1 / 0 | 4.22 | - | nan | - | |
| 190 | p.Asn190Ser | c.569A>G | 1.37e-06 | 2 / 0 | 4.20 | 0.157 | BENIGN | 1.00 | |
| 190 | p.Asn190Lys | c.570T>G | 6.84e-07 | 1 / 0 | 4.20 | - | nan | - | |
| 190 | p.Asn190Lys | c.570T>A | 8.21e-05 | 120 / 0 | 4.20 | - | nan | - | rs34074916 |
| 335 | p.Pro335Arg | c.1004C>G | 6.57e-06 | 1 / 0 | 4.19 | 1.000 | PATHOGENIC | 1.00 | rs1412224107 |
| 340 | p.Phe340Leu | c.1020T>G | 6.16e-06 | 9 / 0 | 4.19 | 0.981 | PATHOGENIC | 0.88 | rs1792129299 |
| 73 | p.Ile73Val | c.217A>G | 2.06e-06 | 3 / 0 | 4.09 | 0.172 | BENIGN | 0.98 | |
| 73 | p.Ile73Thr | c.218T>C | 6.88e-07 | 1 / 0 | 4.09 | - | nan | - | rs1779658672 |
| 180 | p.Phe180Ser | c.539T>C | 1.85e-05 | 27 / 0 | 4.07 | 0.950 | PATHOGENIC | 0.98 | rs769509205 |
| 169 | p.Ile169Leu | c.505A>C | 6.84e-07 | 1 / 0 | 4.07 | 0.259 | BENIGN | 0.81 | |
| 169 | p.Ile169Val | c.505A>G | 6.57e-06 | 1 / 0 | 4.07 | - | nan | - | rs1791691188 |
| 169 | p.Ile169Thr | c.506T>C | 2.05e-06 | 3 / 0 | 4.07 | - | nan | - | |
| 169 | p.Ile169Met | c.507T>G | 6.57e-06 | 1 / 0 | 4.07 | - | nan | - | rs1791692517 |
| 92 | p.Met92Arg | c.275T>G | 1.40e-06 | 2 / 0 | 3.94 | 0.997 | PATHOGENIC | 0.99 | rs747290680 |
| 92 | p.Met92Lys | c.275T>A | 6.98e-07 | 1 / 0 | 3.94 | - | nan | - | |
| 267 | p.Leu267Pro | c.800T>C | 1.37e-06 | 2 / 0 | 3.93 | 0.947 | PATHOGENIC | 0.99 | rs761129137 |
| 267 | p.Leu267His | c.800T>A | 1.37e-06 | 0 / 1 | 3.93 | - | nan | - | rs761129137 |
| 150 | p.Tyr150Asp | c.448T>G | 6.84e-07 | 1 / 0 | 3.93 | 0.988 | PATHOGENIC | 1.00 | |
| 129 | p.Asn129Tyr | c.385A>T | 6.84e-07 | 1 / 0 | 3.92 | 0.597 | PATHOGENIC | 0.57 | |
| 349 | p.Phe349Cys | c.1046T>G | 6.84e-07 | 1 / 0 | 3.90 | 0.964 | PATHOGENIC | 0.99 | |
| 155 | p.Thr155Ile | c.464C>T | 1.55e-04 | 226 / 0 | 3.87 | 0.946 | PATHOGENIC | 0.95 | rs202022370 |
| 193 | p.Asn193Asp | c.577A>G | 6.84e-07 | 1 / 0 | 3.87 | 0.730 | PATHOGENIC | 0.59 | rs755039601 |
| 193 | p.Asn193Ser | c.578A>G | 5.47e-06 | 8 / 0 | 3.87 | - | nan | - | |
| 193 | p.Asn193Lys | c.579C>A | 6.84e-07 | 1 / 0 | 3.87 | - | nan | - | rs1185829859 |
| 137 | p.Phe137Leu | c.409T>C | 6.84e-07 | 1 / 0 | 3.85 | 0.996 | PATHOGENIC | 1.00 | rs1210840287 |
| 125 | p.Phe125Leu | c.375C>G | 5.47e-05 | 80 / 0 | 3.85 | 0.992 | PATHOGENIC | 1.00 | rs77806090 |
| 137 | p.Phe137Ser | c.410T>C | 2.05e-06 | 3 / 0 | 3.85 | - | nan | - | rs1276028790 |
| 137 | p.Phe137Cys | c.410T>G | 6.84e-07 | 1 / 0 | 3.85 | - | nan | - | |
| 158 | p.Phe158Ser | c.473T>C | 6.84e-07 | 1 / 0 | 3.70 | 0.975 | PATHOGENIC | 0.99 | |
| 223 | p.Phe223Ser | c.668T>C | 3.42e-06 | 5 / 0 | 3.69 | 0.987 | PATHOGENIC | 0.97 | rs770684457 |
| 320 | p.Trp320Leu | c.959G>T | 6.84e-07 | 1 / 0 | 3.65 | 0.728 | PATHOGENIC | 0.67 | |
| 301 | p.Tyr301Cys | c.902A>G | 6.84e-07 | 1 / 0 | 3.65 | 0.555 | AMBIGUOUS | 0.86 | |
| 197 | p.Ser197Phe | c.590C>T | 4.10e-06 | 6 / 0 | 3.61 | 0.998 | PATHOGENIC | 0.95 | |
| 197 | p.Ser197Tyr | c.590C>A | 6.84e-07 | 1 / 0 | 3.61 | - | nan | - | |
| 162 | p.Thr162Pro | c.484A>C | 6.84e-07 | 1 / 0 | 3.59 | 0.953 | PATHOGENIC | 0.67 | |
| 162 | p.Thr162Ser | c.485C>G | 6.84e-07 | 1 / 0 | 3.59 | - | nan | - | rs1345025227 |
| 198 | p.Ser198Leu | c.593C>T | 6.84e-07 | 1 / 0 | 3.56 | 0.812 | PATHOGENIC | 1.00 | |
| 156 | p.Ser156Asn | c.467G>A | 1.37e-06 | 2 / 0 | 3.53 | 0.994 | PATHOGENIC | 1.00 | |
| 63 | p.Gly63Ser | c.187G>A | 1.31e-05 | 2 / 0 | 3.46 | 0.076 | BENIGN | 0.54 | rs777180052 |
| 63 | p.Gly63Val | c.188G>T | 3.98e-05 | 58 / 0 | 3.46 | - | nan | - | rs9282817 |
| 63 | p.Gly63Asp | c.188G>A | 5.49e-06 | 8 / 0 | 3.46 | - | nan | - | rs9282817 |
| 257 | p.Met257Lys | c.770T>A | 6.57e-06 | 1 / 0 | 3.42 | 0.999 | PATHOGENIC | 1.00 | rs1792035857 |
| 168 | p.Tyr168His | c.502T>C | 6.84e-07 | 1 / 0 | 3.42 | 0.995 | PATHOGENIC | 1.00 | |
| 168 | p.Tyr168Cys | c.503A>G | 1.16e-05 | 17 / 0 | 3.42 | - | nan | - | rs199749405 |
| 257 | p.Met257Ile | c.771G>C | 1.09e-05 | 16 / 0 | 3.42 | - | nan | - | rs201750403 |
| 257 | p.Met257Ile | c.771G>T | 5.20e-05 | 76 / 0 | 3.42 | - | nan | - | rs201750403 |
| 257 | p.Met257Ile | c.771G>A | 1.37e-06 | 2 / 0 | 3.42 | - | nan | - | rs201750403 |
| 338 | p.Tyr338Cys | c.1013A>G | 1.37e-05 | 20 / 0 | 3.36 | 0.995 | PATHOGENIC | 1.00 | rs201429844 |
| 109 | p.Ile109Phe | c.325A>T | 2.05e-06 | 3 / 0 | 3.36 | 0.992 | PATHOGENIC | 1.00 | |
| 181 | p.Arg181Cys | c.541C>T | 1.83e-03 | 2659 / 6 | 3.36 | 0.987 | PATHOGENIC | 0.99 | rs79910351 |
| 181 | p.Arg181His | c.542G>A | 2.80e-05 | 41 / 0 | 3.36 | - | nan | - | rs748807412 |
| 384 | p.Arg384Gly | c.1150A>G | 2.74e-06 | 4 / 0 | 3.35 | 0.176 | BENIGN | 0.69 | rs1210793358 |
| 383 | p.Asp383Asn | c.1147G>A | 1.37e-06 | 2 / 0 | 3.35 | 0.111 | BENIGN | 0.73 | rs746718852 |
| 383 | p.Asp383Gly | c.1148A>G | 6.85e-07 | 1 / 0 | 3.35 | - | nan | - | |
| 99 | p.Thr99Ala | c.295A>G | 4.12e-06 | 6 / 0 | 3.26 | 0.564 | AMBIGUOUS | 1.00 | rs774733136 |
| 99 | p.Thr99Asn | c.296C>A | 2.06e-06 | 3 / 0 | 3.26 | - | nan | - | |
| 204 | p.Val204Ile | c.610G>A | 2.74e-06 | 4 / 0 | 3.24 | 0.218 | BENIGN | 0.66 | |
| 222 | p.Thr222Ile | c.665C>T | 6.84e-07 | 1 / 0 | 3.14 | 0.159 | BENIGN | 0.44 | rs777753483 |
| 253 | p.Cys253Ser | c.757T>A | 6.84e-07 | 1 / 0 | 3.14 | 0.922 | PATHOGENIC | 1.00 | |
| 253 | p.Cys253Ser | c.758G>C | 1.37e-06 | 2 / 0 | 3.14 | - | nan | - | rs752365239 |
| 253 | p.Cys253Tyr | c.758G>A | 1.37e-06 | 2 / 0 | 3.14 | - | nan | - | rs752365239 |
| 305 | p.Lys305Arg | c.914A>G | 1.37e-06 | 2 / 0 | 3.10 | 0.111 | BENIGN | 0.59 | rs200318741 |
| 50 | p.Ala50Pro | c.148G>C | 1.40e-06 | 2 / 0 | 3.02 | 0.114 | BENIGN | 0.43 | |
| 51 | p.Thr51Ala | c.151A>G | 6.57e-06 | 1 / 0 | 3.02 | 0.085 | BENIGN | 0.36 | rs535843430 |
| 50 | p.Ala50Val | c.149C>T | 1.40e-06 | 2 / 0 | 3.02 | - | nan | - | rs9282815 |
| 50 | p.Ala50Asp | c.149C>A | 7.67e-04 | 1051 / 23 | 3.02 | - | nan | - | rs9282815 |
| 51 | p.Thr51Ile | c.152C>T | 2.09e-06 | 3 / 0 | 3.02 | - | nan | - | rs370868117 |
| 50 | p.Thr50Ala | c.148A>G | 6.84e-07 | 1 / 0 | 3.02 | - | nan | - | |
| 51 | p.Asp51Tyr | c.151G>T | 6.84e-07 | 1 / 0 | 3.02 | - | nan | - | |
| 51 | p.Asp51Asn | c.151G>A | 7.53e-06 | 11 / 0 | 3.02 | - | nan | - | rs1042753 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.52, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 98 | TYR | 352 | PHE | 13.902 | 0.000 | 13.902 | 13.902 |
| 34 | LEU | 312 | GLU | 9.811 | 0.000 | 9.811 | 9.811 |
| 36 | HIS | 62 | THR | 0.000 | 9.025 | -9.025 | 9.025 |
| 167 | ARG | 281 | THR | 0.000 | 8.873 | -8.873 | 8.873 |
| 254 | TYR | 285 | LEU | 0.000 | 8.863 | -8.863 | 8.863 |
| 27 | SER | 231 | GLU | 8.536 | 0.000 | 8.536 | 8.536 |
| 77 | TYR | 321 | HIS | 8.227 | 0.000 | 8.227 | 8.227 |
| 151 | TYR | 194 | TRP | 9.929 | 2.441 | 7.488 | 7.488 |
| 167 | ARG | 277 | LEU | 0.000 | 7.255 | -7.255 | 7.255 |
| 387 | HIS | 388 | GLN | 0.000 | 6.633 | -6.633 | 6.633 |
| 101 | MET | 106 | ASN | 0.160 | 6.295 | -6.135 | 6.135 |
| 36 | HIS | 214 | GLN | 6.033 | 0.000 | 6.033 | 6.033 |
| 390 | GLU | 391 | ASN | 0.000 | 5.935 | -5.935 | 5.935 |
| 118 | LEU | 152 | ASN | 5.736 | 0.000 | 5.736 | 5.736 |
| 167 | ARG | 280 | ILE | 0.000 | 5.543 | -5.543 | 5.543 |
| 27 | SER | 227 | THR | 0.023 | 5.534 | -5.510 | 5.510 |
| 31 | TRP | 302 | VAL | 0.000 | 5.491 | -5.491 | 5.491 |
| 274 | ASP | 278 | ARG | 1.415 | 6.884 | -5.468 | 5.468 |
| 167 | ARG | 254 | TYR | 5.468 | 0.000 | 5.468 | 5.468 |
| 339 | ALA | 345 | PHE | 5.426 | 0.069 | 5.356 | 5.356 |
| 37 | LEU | 214 | GLN | 5.266 | 0.000 | 5.266 | 5.266 |
| 28 | PRO | 235 | LYS | 5.062 | 0.000 | 5.062 | 5.062 |
| 341 | LEU | 346 | LYS | 4.935 | 0.000 | 4.935 | 4.935 |
| 32 | VAL | 218 | ASP | 4.914 | 0.000 | 4.914 | 4.914 |
| 164 | SER | 254 | TYR | 6.540 | 1.647 | 4.893 | 4.893 |
| 29 | GLY | 221 | LEU | 0.416 | 5.201 | -4.785 | 4.785 |
| 28 | PRO | 34 | LEU | 0.000 | 4.630 | -4.630 | 4.630 |
| 395 | GLU | 396 | THR | 0.000 | 4.572 | -4.572 | 4.572 |
| 28 | PRO | 231 | GLU | 7.315 | 2.765 | 4.550 | 4.550 |
| 347 | ARG | 351 | GLU | 0.000 | 4.465 | -4.465 | 4.465 |
| 123 | LEU | 328 | TYR | 7.643 | 3.230 | 4.413 | 4.413 |
| 385 | THR | 386 | ASN | 0.044 | 4.456 | -4.411 | 4.411 |
| 101 | MET | 345 | PHE | 0.000 | 4.322 | -4.322 | 4.322 |
| 266 | MET | 273 | LYS | 4.219 | 0.000 | 4.219 | 4.219 |
| 108 | TYR | 190 | ASN | 6.913 | 2.711 | 4.202 | 4.202 |
| 335 | PRO | 340 | PHE | 4.193 | 0.000 | 4.193 | 4.193 |
| 73 | ILE | 130 | TYR | 4.644 | 0.555 | 4.089 | 4.089 |
| 169 | ILE | 180 | PHE | 4.074 | 0.000 | 4.074 | 4.074 |
| 92 | MET | 110 | PHE | 2.850 | 6.788 | -3.939 | 3.939 |
| 267 | LEU | 274 | ASP | 1.691 | 5.623 | -3.932 | 3.932 |
| 31 | TRP | 150 | TYR | 0.000 | 3.927 | -3.927 | 3.927 |
| 31 | TRP | 129 | ASN | 3.920 | 0.000 | 3.920 | 3.920 |
| 90 | LEU | 349 | PHE | 0.000 | 3.897 | -3.897 | 3.897 |
| 32 | VAL | 130 | TYR | 0.000 | 3.882 | -3.882 | 3.882 |
| 155 | THR | 193 | ASN | 0.000 | 3.874 | -3.874 | 3.874 |
| 125 | PHE | 137 | PHE | 2.916 | 6.764 | -3.848 | 3.848 |
| 336 | VAL | 341 | LEU | 3.750 | 0.000 | 3.750 | 3.750 |
| 158 | PHE | 193 | ASN | 2.251 | 5.953 | -3.702 | 3.702 |
| 223 | PHE | 231 | GLU | 8.093 | 4.405 | 3.689 | 3.689 |
| 301 | TYR | 320 | TRP | 4.223 | 7.870 | -3.647 | 3.647 |
| 151 | TYR | 197 | SER | 7.159 | 3.554 | 3.606 | 3.606 |
| 162 | THR | 193 | ASN | 3.593 | 0.000 | 3.593 | 3.593 |
| 151 | TYR | 198 | SER | 3.712 | 7.268 | -3.556 | 3.556 |
| 116 | ASP | 156 | SER | 3.633 | 0.105 | 3.528 | 3.528 |
| 267 | LEU | 273 | LYS | 3.516 | 0.000 | 3.516 | 3.516 |
| 36 | HIS | 63 | GLY | 0.000 | 3.464 | -3.464 | 3.464 |
| 168 | TYR | 257 | MET | 0.148 | 3.572 | -3.424 | 3.424 |
| 77 | TYR | 123 | LEU | 1.042 | 4.460 | -3.419 | 3.419 |
| 109 | ILE | 338 | TYR | 1.223 | 4.585 | -3.362 | 3.362 |
| 166 | ASP | 181 | ARG | 7.733 | 11.093 | -3.360 | 3.360 |
| 383 | ASP | 384 | ARG | 0.000 | 3.345 | -3.345 | 3.345 |
| 90 | LEU | 352 | PHE | 0.000 | 3.318 | -3.318 | 3.318 |
| 339 | ALA | 346 | LYS | 0.000 | 3.316 | -3.316 | 3.316 |
| 99 | THR | 106 | ASN | 3.263 | 0.000 | 3.263 | 3.263 |
| 150 | TYR | 204 | VAL | 1.285 | 4.524 | -3.239 | 3.239 |
| 340 | PHE | 346 | LYS | 3.203 | 0.000 | 3.203 | 3.203 |
| 211 | LYS | 222 | THR | 3.144 | 0.000 | 3.144 | 3.144 |
| 168 | TYR | 253 | CYS | 4.409 | 1.268 | 3.141 | 3.141 |
| 167 | ARG | 338 | TYR | 3.121 | 0.000 | 3.121 | 3.121 |
| 34 | LEU | 305 | LYS | 0.000 | 3.102 | -3.102 | 3.102 |
| 50 | THR | 51 | ASP | 3.833 | 0.817 | 3.016 | 3.016 |
| 151 | TYR | 201 | GLY | 0.604 | 3.602 | -2.998 | 2.998 |
| 160 | LEU | 338 | TYR | 2.991 | 0.000 | 2.991 | 2.991 |
| 35 | SER | 63 | GLY | 1.661 | 4.646 | -2.984 | 2.984 |
| 154 | PHE | 200 | ILE | 2.461 | 5.428 | -2.967 | 2.967 |
| 272 | GLU | 276 | ASN | 0.556 | 3.512 | -2.956 | 2.956 |
| 224 | SER | 230 | TRP | 4.762 | 7.710 | -2.948 | 2.948 |
| 322 | PHE | 326 | LEU | 2.933 | 0.000 | 2.933 | 2.933 |
| 180 | PHE | 185 | ASN | 6.926 | 4.008 | 2.917 | 2.917 |
| 291 | PHE | 330 | ASN | 1.382 | 4.189 | -2.807 | 2.807 |
| 298 | ILE | 323 | CYS | 4.584 | 1.782 | 2.802 | 2.802 |
| 157 | ILE | 295 | TRP | 2.798 | 0.000 | 2.798 | 2.798 |
| 77 | TYR | 324 | ILE | 3.817 | 1.070 | 2.747 | 2.747 |
| 159 | THR | 193 | ASN | 0.519 | 3.244 | -2.725 | 2.725 |
| 254 | TYR | 257 | MET | 1.043 | 3.757 | -2.715 | 2.715 |
| 295 | TRP | 327 | GLY | 1.904 | 4.611 | -2.706 | 2.706 |
| 185 | ASN | 189 | ILE | 2.694 | 0.000 | 2.694 | 2.694 |
| 182 | THR | 185 | ASN | 1.145 | 3.833 | -2.688 | 2.688 |
| 250 | ILE | 291 | PHE | 2.662 | 0.000 | 2.662 | 2.662 |
| 96 | VAL | 102 | LYS | 0.000 | 2.649 | -2.649 | 2.649 |
| 98 | TYR | 351 | GLU | 0.000 | 2.647 | -2.647 | 2.647 |
| 122 | THR | 149 | ASP | 3.310 | 0.730 | 2.580 | 2.580 |
| 111 | ASN | 159 | THR | 0.242 | 2.818 | -2.575 | 2.575 |
| 343 | GLU | 346 | LYS | 3.890 | 1.367 | 2.523 | 2.523 |
| 33 | ASN | 35 | SER | 2.486 | 0.000 | 2.486 | 2.486 |
| 272 | GLU | 275 | ARG | 6.393 | 3.940 | 2.452 | 2.452 |
| 95 | ILE | 100 | LYS | 2.412 | 0.000 | 2.412 | 2.412 |
| 155 | THR | 194 | TRP | 6.366 | 3.966 | 2.400 | 2.400 |
| 30 | SER | 213 | ARG | 2.397 | 0.000 | 2.397 | 2.397 |
| 135 | TRP | 219 | CYS | 6.068 | 3.671 | 2.397 | 2.397 |
| 171 | VAL | 260 | ARG | 2.673 | 0.286 | 2.388 | 2.388 |
| 74 | MET | 127 | SER | 3.940 | 1.553 | 2.386 | 2.386 |
| 268 | SER | 273 | LYS | 0.207 | 2.581 | -2.373 | 2.373 |
| 160 | LEU | 291 | PHE | 1.069 | 3.442 | -2.373 | 2.373 |
| 107 | ILE | 186 | ALA | 0.199 | 2.556 | -2.358 | 2.358 |
| 295 | TRP | 299 | HIS | 3.143 | 0.786 | 2.356 | 2.356 |
| 209 | THR | 222 | THR | 4.529 | 2.174 | 2.355 | 2.355 |
| 153 | MET | 295 | TRP | 2.512 | 0.160 | 2.352 | 2.352 |
| 93 | TYR | 97 | ARG | 0.479 | 2.808 | -2.328 | 2.328 |
| 301 | TYR | 319 | SER | 1.770 | 4.088 | -2.318 | 2.318 |
| 339 | ALA | 349 | PHE | 0.000 | 2.303 | -2.303 | 2.303 |
| 338 | TYR | 345 | PHE | 0.000 | 2.285 | -2.285 | 2.285 |
| 97 | ARG | 98 | TYR | 3.078 | 0.807 | 2.271 | 2.271 |
| 129 | ASN | 134 | THR | 3.616 | 5.886 | -2.270 | 2.270 |
| 147 | SER | 151 | TYR | 0.000 | 2.269 | -2.269 | 2.269 |
| 166 | ASP | 180 | PHE | 2.264 | 0.000 | 2.264 | 2.264 |
| 291 | PHE | 295 | TRP | 4.224 | 6.474 | -2.250 | 2.250 |
| 151 | TYR | 202 | LEU | 0.000 | 2.241 | -2.241 | 2.241 |
| 154 | PHE | 242 | ALA | 1.562 | 3.769 | -2.207 | 2.207 |
| 155 | THR | 197 | SER | 5.535 | 3.335 | 2.201 | 2.201 |
| 88 | ASN | 117 | ALA | 3.679 | 1.489 | 2.190 | 2.190 |
| 243 | PHE | 296 | THR | 5.866 | 3.683 | 2.183 | 2.183 |
| 207 | MET | 222 | THR | 9.666 | 7.483 | 2.183 | 2.183 |
| 295 | TRP | 330 | ASN | 3.989 | 1.816 | 2.173 | 2.173 |
| 94 | VAL | 348 | CYS | 0.000 | 2.168 | -2.168 | 2.168 |
| 150 | TYR | 234 | LEU | 0.000 | 2.151 | -2.151 | 2.151 |
| 31 | TRP | 219 | CYS | 2.140 | 0.000 | 2.140 | 2.140 |
| 108 | TYR | 189 | ILE | 1.030 | 3.154 | -2.124 | 2.124 |
| 168 | TYR | 173 | HIS | 4.145 | 2.025 | 2.120 | 2.120 |
| 163 | MET | 338 | TYR | 2.104 | 0.000 | 2.104 | 2.104 |
| 136 | PRO | 137 | PHE | 2.431 | 4.525 | -2.095 | 2.095 |
| 135 | TRP | 137 | PHE | 7.530 | 5.442 | 2.088 | 2.088 |
| 170 | ALA | 181 | ARG | 2.479 | 4.543 | -2.064 | 2.064 |
| 30 | SER | 219 | CYS | 0.000 | 2.053 | -2.053 | 2.053 |
| 125 | PHE | 145 | VAL | 2.021 | 0.000 | 2.021 | 2.021 |
| 163 | MET | 284 | VAL | 0.000 | 1.998 | -1.998 | 1.998 |
| 26 | PRO | 37 | LEU | 0.000 | 1.982 | -1.982 | 1.982 |
| 116 | ASP | 334 | ASN | 5.085 | 3.118 | 1.967 | 1.967 |
| 212 | TYR | 217 | ILE | 0.150 | 2.115 | -1.965 | 1.965 |
| 160 | LEU | 334 | ASN | 1.960 | 0.000 | 1.960 | 1.960 |
| 77 | TYR | 325 | ALA | 0.192 | 2.151 | -1.959 | 1.959 |
| 380 | ASN | 381 | THR | 2.323 | 0.365 | 1.958 | 1.958 |
| 340 | PHE | 349 | PHE | 1.938 | 0.000 | 1.938 | 1.938 |
| 107 | ILE | 190 | ASN | 1.536 | 3.456 | -1.919 | 1.919 |
| 391 | ASN | 392 | LEU | 0.000 | 1.916 | -1.916 | 1.916 |
| 330 | ASN | 334 | ASN | 2.390 | 0.476 | 1.914 | 1.914 |
| 239 | PHE | 303 | ILE | 1.680 | 3.546 | -1.867 | 1.867 |
| 279 | ARG | 343 | GLU | 3.258 | 1.392 | 1.866 | 1.866 |
| 88 | ASN | 116 | ASP | 5.734 | 3.892 | 1.842 | 1.842 |
| 153 | MET | 299 | HIS | 0.000 | 1.831 | -1.831 | 1.831 |
| 384 | ARG | 385 | THR | 0.000 | 1.819 | -1.819 | 1.819 |
| 33 | ASN | 218 | ASP | 0.000 | 1.811 | -1.811 | 1.811 |
| 151 | TYR | 152 | ASN | 1.804 | 0.000 | 1.804 | 1.804 |
| 2 | ASP | 3 | SER | 0.223 | 2.026 | -1.802 | 1.802 |
| 119 | ALA | 328 | TYR | 1.895 | 0.105 | 1.790 | 1.790 |
| 95 | ILE | 99 | THR | 1.790 | 0.000 | 1.790 | 1.790 |
| 161 | CYS | 246 | PRO | 2.162 | 0.376 | 1.786 | 1.786 |
| 356 | THR | 358 | SER | 1.756 | 0.000 | 1.756 | 1.756 |
| 287 | VAL | 338 | TYR | 2.599 | 0.871 | 1.728 | 1.728 |
| 180 | PHE | 189 | ILE | 1.725 | 0.000 | 1.725 | 1.725 |
| 157 | ILE | 291 | PHE | 0.777 | 2.471 | -1.694 | 1.694 |
| 170 | ALA | 277 | LEU | 0.000 | 1.685 | -1.685 | 1.685 |
| 101 | MET | 107 | ILE | 1.675 | 0.000 | 1.675 | 1.675 |
| 158 | PHE | 196 | LEU | 0.698 | 2.369 | -1.671 | 1.671 |
| 242 | ALA | 299 | HIS | 1.913 | 0.244 | 1.668 | 1.668 |
| 167 | ARG | 284 | VAL | 0.000 | 1.658 | -1.658 | 1.658 |
| 94 | VAL | 101 | MET | 0.000 | 1.640 | -1.640 | 1.640 |
| 239 | PHE | 299 | HIS | 2.840 | 1.204 | 1.636 | 1.636 |
| 95 | ILE | 102 | LYS | 0.000 | 1.615 | -1.615 | 1.615 |
| 77 | TYR | 328 | TYR | 0.000 | 1.613 | -1.613 | 1.613 |
| 107 | ILE | 187 | LYS | 0.771 | 2.382 | -1.611 | 1.611 |
| 247 | VAL | 291 | PHE | 1.583 | 0.000 | 1.583 | 1.583 |
| 225 | HIS | 226 | PRO | 1.568 | 0.000 | 1.568 | 1.568 |
| 31 | TRP | 320 | TRP | 0.000 | 1.552 | -1.552 | 1.552 |
| 112 | LEU | 160 | LEU | 1.978 | 0.429 | 1.549 | 1.549 |
| 152 | ASN | 156 | SER | 0.000 | 1.546 | -1.546 | 1.546 |
| 65 | PRO | 130 | TYR | 1.655 | 0.119 | 1.536 | 1.536 |
| 101 | MET | 344 | ASN | 0.000 | 1.523 | -1.523 | 1.523 |
| 101 | MET | 110 | PHE | 1.523 | 0.000 | 1.523 | 1.523 |
| 111 | ASN | 190 | ASN | 5.724 | 7.247 | -1.522 | 1.522 |
| 153 | MET | 238 | VAL | 0.621 | 2.125 | -1.503 | 1.503 |
| 152 | ASN | 194 | TRP | 1.501 | 0.000 | 1.501 | 1.501 |
| 156 | SER | 291 | PHE | 0.000 | 1.496 | -1.496 | 1.496 |
| 91 | VAL | 339 | ALA | 1.488 | 0.000 | 1.488 | 1.488 |
| 286 | VAL | 341 | LEU | 0.000 | 1.482 | -1.482 | 1.482 |
| 112 | LEU | 116 | ASP | 2.137 | 0.662 | 1.474 | 1.474 |
| 342 | ASP | 345 | PHE | 0.919 | 2.373 | -1.453 | 1.453 |
| 243 | PHE | 295 | TRP | 1.453 | 0.000 | 1.453 | 1.453 |
| 246 | PRO | 291 | PHE | 1.448 | 0.000 | 1.448 | 1.448 |
| 73 | ILE | 77 | TYR | 1.280 | 2.727 | -1.446 | 1.446 |
| 258 | ILE | 284 | VAL | 1.439 | 0.000 | 1.439 | 1.439 |
| 69 | THR | 314 | THR | 1.434 | 0.000 | 1.434 | 1.434 |
| 160 | LEU | 288 | VAL | 0.000 | 1.398 | -1.398 | 1.398 |
| 108 | TYR | 163 | MET | 1.787 | 3.183 | -1.397 | 1.397 |
| 125 | PHE | 141 | LEU | 1.273 | 2.664 | -1.392 | 1.392 |
| 77 | TYR | 127 | SER | 1.968 | 0.577 | 1.391 | 1.391 |
| 129 | ASN | 135 | TRP | 3.571 | 4.950 | -1.378 | 1.378 |
| 108 | TYR | 159 | THR | 0.901 | 2.275 | -1.374 | 1.374 |
| 98 | TYR | 348 | CYS | 0.000 | 1.365 | -1.365 | 1.365 |
| 254 | TYR | 288 | VAL | 1.350 | 0.000 | 1.350 | 1.350 |
| 87 | GLY | 335 | PRO | 2.905 | 4.254 | -1.349 | 1.349 |
| 261 | LEU | 277 | LEU | 1.347 | 0.000 | 1.347 | 1.347 |
| 30 | SER | 218 | ASP | 1.345 | 0.000 | 1.345 | 1.345 |
| 148 | ILE | 152 | ASN | 1.340 | 0.000 | 1.340 | 1.340 |
| 95 | ILE | 106 | ASN | 0.740 | 2.065 | -1.325 | 1.325 |
| 116 | ASP | 331 | SER | 11.299 | 12.616 | -1.317 | 1.317 |
| 283 | MET | 342 | ASP | 0.000 | 1.303 | -1.303 | 1.303 |
| 283 | MET | 341 | LEU | 0.689 | 1.964 | -1.274 | 1.274 |
| 94 | VAL | 99 | THR | 1.271 | 0.000 | 1.271 | 1.271 |
| 122 | THR | 126 | GLN | 0.462 | 1.732 | -1.270 | 1.270 |
| 279 | ARG | 341 | LEU | 0.000 | 1.265 | -1.265 | 1.265 |
| 49 | ARG | 50 | THR | 0.000 | 1.255 | -1.255 | 1.255 |
| 216 | SER | 218 | ASP | 1.904 | 0.650 | 1.254 | 1.254 |
| 276 | ASN | 279 | ARG | 0.000 | 1.249 | -1.249 | 1.249 |
| 91 | VAL | 338 | TYR | 0.000 | 1.245 | -1.245 | 1.245 |
| 398 | PRO | 399 | LEU | 0.000 | 1.240 | -1.240 | 1.240 |
| 279 | ARG | 346 | LYS | 1.236 | 0.000 | 1.236 | 1.236 |
| 143 | LYS | 205 | MET | 5.031 | 6.265 | -1.234 | 1.234 |
| 91 | VAL | 340 | PHE | 1.233 | 0.000 | 1.233 | 1.233 |
| 29 | GLY | 220 | THR | 4.201 | 2.973 | 1.229 | 1.229 |
| 112 | LEU | 159 | THR | 1.801 | 0.578 | 1.224 | 1.224 |
| 171 | VAL | 267 | LEU | 0.000 | 1.206 | -1.206 | 1.206 |
| 243 | PHE | 247 | VAL | 1.598 | 0.393 | 1.204 | 1.204 |
| 126 | GLN | 328 | TYR | 4.796 | 6.000 | -1.204 | 1.204 |
| 32 | VAL | 133 | GLY | 1.201 | 0.000 | 1.201 | 1.201 |
| 261 | LEU | 278 | ARG | 0.000 | 1.199 | -1.199 | 1.199 |
| 254 | TYR | 281 | THR | 0.000 | 1.190 | -1.190 | 1.190 |
| 161 | CYS | 250 | ILE | 0.644 | 1.832 | -1.188 | 1.188 |
| 116 | ASP | 152 | ASN | 0.000 | 1.188 | -1.188 | 1.188 |
| 135 | TRP | 217 | ILE | 6.990 | 5.805 | 1.185 | 1.185 |
| 229 | TYR | 230 | TRP | 3.936 | 5.104 | -1.168 | 1.168 |
| 171 | VAL | 277 | LEU | 0.000 | 1.142 | -1.142 | 1.142 |
| 198 | SER | 202 | LEU | 1.856 | 0.716 | 1.140 | 1.140 |
| 381 | THR | 382 | VAL | 1.367 | 0.228 | 1.138 | 1.138 |
| 240 | ILE | 245 | MET | 4.156 | 3.018 | 1.137 | 1.137 |
| 161 | CYS | 249 | ILE | 0.905 | 2.038 | -1.134 | 1.134 |
| 154 | PHE | 241 | PHE | 1.615 | 0.487 | 1.129 | 1.129 |
| 382 | VAL | 383 | ASP | 2.116 | 0.992 | 1.125 | 1.125 |
| 164 | SER | 253 | CYS | 2.597 | 1.473 | 1.123 | 1.123 |
| 151 | TYR | 155 | THR | 1.244 | 0.125 | 1.119 | 1.119 |
| 134 | THR | 216 | SER | 2.985 | 1.881 | 1.104 | 1.104 |
| 132 | MET | 136 | PRO | 1.495 | 0.392 | 1.103 | 1.103 |
| 207 | MET | 223 | PHE | 1.309 | 0.215 | 1.095 | 1.095 |
| 301 | TYR | 316 | GLN | 5.753 | 6.820 | -1.067 | 1.067 |
| 266 | MET | 271 | LYS | 0.000 | 1.066 | -1.066 | 1.066 |
| 243 | PHE | 299 | HIS | 5.770 | 6.826 | -1.056 | 1.056 |
| 91 | VAL | 349 | PHE | 0.000 | 1.054 | -1.054 | 1.054 |
| 167 | ARG | 181 | ARG | 0.026 | 1.070 | -1.044 | 1.044 |
| 150 | TYR | 221 | LEU | 0.589 | 1.630 | -1.042 | 1.042 |
| 30 | SER | 220 | THR | 2.927 | 3.967 | -1.040 | 1.040 |
| 119 | ALA | 148 | ILE | 0.000 | 1.040 | -1.040 | 1.040 |
| 105 | THR | 280 | ILE | 0.000 | 1.040 | -1.040 | 1.040 |
| 258 | ILE | 281 | THR | 1.038 | 0.000 | 1.038 | 1.038 |
| 375 | HIS | 376 | PRO | 1.227 | 0.192 | 1.035 | 1.035 |
| 171 | VAL | 261 | LEU | 1.453 | 0.423 | 1.030 | 1.030 |
| 122 | THR | 328 | TYR | 1.024 | 0.000 | 1.024 | 1.024 |
| 260 | ARG | 263 | SER | 1.348 | 0.330 | 1.018 | 1.018 |
| 267 | LEU | 278 | ARG | 0.000 | 1.010 | -1.010 | 1.010 |
| 90 | LEU | 340 | PHE | 1.003 | 0.000 | 1.003 | 1.003 |
| 76 | LEU | 325 | ALA | 1.664 | 0.661 | 1.003 | 1.003 |
| 111 | ASN | 193 | ASN | 0.000 | 1.001 | -1.001 | 1.001 |
| 160 | LEU | 250 | ILE | 0.324 | 1.317 | -0.993 | 0.993 |
| 10 | ALA | 11 | SER | 0.000 | 0.980 | -0.980 | 0.980 |
| 37 | LEU | 213 | ARG | 0.000 | 0.978 | -0.978 | 0.978 |
| 356 | THR | 359 | ASN | 0.163 | 1.140 | -0.977 | 0.977 |
| 337 | LEU | 338 | TYR | 0.968 | 0.000 | 0.968 | 0.968 |
| 95 | ILE | 110 | PHE | 3.262 | 2.302 | 0.960 | 0.960 |
| 171 | VAL | 257 | MET | 2.431 | 1.478 | 0.953 | 0.953 |
| 396 | THR | 397 | ALA | 0.000 | 0.953 | -0.953 | 0.953 |
| 260 | ARG | 264 | VAL | 1.015 | 1.966 | -0.951 | 0.951 |
| 135 | TRP | 141 | LEU | 1.003 | 1.947 | -0.945 | 0.945 |
| 263 | SER | 264 | VAL | 0.000 | 0.931 | -0.931 | 0.931 |
| 239 | PHE | 243 | PHE | 1.909 | 0.984 | 0.925 | 0.925 |
| 204 | VAL | 221 | LEU | 1.279 | 2.198 | -0.920 | 0.920 |
| 126 | GLN | 145 | VAL | 0.000 | 0.913 | -0.913 | 0.913 |
| 223 | PHE | 227 | THR | 0.592 | 1.479 | -0.887 | 0.887 |
| 218 | ASP | 220 | THR | 0.047 | 0.933 | -0.886 | 0.886 |
| 157 | ILE | 158 | PHE | 0.000 | 0.878 | -0.878 | 0.878 |
| 139 | THR | 209 | THR | 0.316 | 1.187 | -0.871 | 0.871 |
| 106 | ASN | 345 | PHE | 0.780 | 1.647 | -0.867 | 0.867 |
| 152 | ASN | 295 | TRP | 0.000 | 0.866 | -0.866 | 0.866 |
| 115 | ALA | 194 | TRP | 0.866 | 0.000 | 0.866 | 0.866 |
| 98 | TYR | 101 | MET | 0.000 | 0.863 | -0.863 | 0.863 |
| 74 | MET | 131 | LEU | 1.263 | 0.404 | 0.859 | 0.859 |
| 317 | THR | 321 | HIS | 0.710 | 1.566 | -0.856 | 0.856 |
| 235 | LYS | 302 | VAL | 0.320 | 1.175 | -0.855 | 0.855 |
| 245 | MET | 249 | ILE | 0.000 | 0.855 | -0.855 | 0.855 |
| 115 | ALA | 156 | SER | 1.385 | 0.532 | 0.853 | 0.853 |
| 88 | ASN | 113 | ALA | 5.406 | 6.257 | -0.851 | 0.851 |
| 386 | ASN | 387 | HIS | 0.000 | 0.849 | -0.849 | 0.849 |
| 115 | ALA | 152 | ASN | 4.267 | 3.422 | 0.846 | 0.846 |
| 157 | ILE | 246 | PRO | 1.612 | 2.456 | -0.843 | 0.843 |
| 80 | VAL | 329 | THR | 1.058 | 1.897 | -0.839 | 0.839 |
| 109 | ILE | 283 | MET | 0.000 | 0.838 | -0.838 | 0.838 |
| 91 | VAL | 345 | PHE | 0.202 | 1.031 | -0.830 | 0.830 |
| 83 | VAL | 332 | CYS | 0.000 | 0.816 | -0.816 | 0.816 |
| 296 | THR | 300 | ILE | 1.220 | 0.411 | 0.808 | 0.808 |
| 85 | LEU | 120 | THR | 2.860 | 3.665 | -0.804 | 0.804 |
| 94 | VAL | 349 | PHE | 1.599 | 0.796 | 0.804 | 0.804 |
| 193 | ASN | 197 | SER | 0.000 | 0.799 | -0.799 | 0.799 |
| 37 | LEU | 38 | ASP | 0.000 | 0.795 | -0.795 | 0.795 |
| 254 | TYR | 284 | VAL | 3.609 | 2.821 | 0.788 | 0.788 |
| 118 | LEU | 148 | ILE | 1.284 | 2.071 | -0.788 | 0.788 |
| 345 | PHE | 349 | PHE | 0.442 | 1.226 | -0.784 | 0.784 |
| 95 | ILE | 109 | ILE | 1.345 | 0.564 | 0.781 | 0.781 |
| 114 | LEU | 194 | TRP | 1.494 | 0.723 | 0.771 | 0.771 |
| 147 | SER | 204 | VAL | 0.935 | 0.165 | 0.770 | 0.770 |
| 36 | HIS | 213 | ARG | 0.000 | 0.763 | -0.763 | 0.763 |
| 107 | ILE | 111 | ASN | 0.761 | 0.000 | 0.761 | 0.761 |
| 165 | VAL | 253 | CYS | 0.614 | 1.375 | -0.760 | 0.760 |
| 125 | PHE | 135 | TRP | 2.626 | 1.867 | 0.759 | 0.759 |
| 105 | THR | 166 | ASP | 0.454 | 1.213 | -0.758 | 0.758 |
| 40 | ASN | 41 | LEU | 0.522 | 1.277 | -0.755 | 0.755 |
| 394 | ALA | 395 | GLU | 0.000 | 0.754 | -0.754 | 0.754 |
| 310 | ILE | 311 | PRO | 0.597 | 1.350 | -0.753 | 0.753 |
| 94 | VAL | 345 | PHE | 1.267 | 0.514 | 0.753 | 0.753 |
| 287 | VAL | 334 | ASN | 0.000 | 0.750 | -0.750 | 0.750 |
| 213 | ARG | 218 | ASP | 5.878 | 5.129 | 0.749 | 0.749 |
| 36 | HIS | 312 | GLU | 0.000 | 0.747 | -0.747 | 0.747 |
| 76 | LEU | 322 | PHE | 0.740 | 0.000 | 0.740 | 0.740 |
| 158 | PHE | 246 | PRO | 0.000 | 0.735 | -0.735 | 0.735 |
| 342 | ASP | 344 | ASN | 3.908 | 3.173 | 0.735 | 0.735 |
| 350 | ARG | 354 | ILE | 0.491 | 1.225 | -0.734 | 0.734 |
| 379 | ALA | 380 | ASN | 0.730 | 0.000 | 0.730 | 0.730 |
| 254 | TYR | 287 | VAL | 0.727 | 0.000 | 0.727 | 0.727 |
| 156 | SER | 334 | ASN | 0.722 | 0.000 | 0.722 | 0.722 |
| 112 | LEU | 156 | SER | 2.125 | 2.844 | -0.718 | 0.718 |
| 102 | LYS | 183 | PRO | 1.005 | 1.722 | -0.717 | 0.717 |
| 65 | PRO | 70 | ALA | 0.754 | 0.044 | 0.711 | 0.711 |
| 269 | GLY | 274 | ASP | 0.708 | 0.000 | 0.708 | 0.708 |
| 261 | LEU | 267 | LEU | 2.517 | 1.817 | 0.700 | 0.700 |
| 119 | ALA | 152 | ASN | 1.854 | 2.554 | -0.700 | 0.700 |
| 138 | GLY | 210 | THR | 0.657 | 1.355 | -0.698 | 0.698 |
| 176 | LYS | 180 | PHE | 0.000 | 0.694 | -0.694 | 0.694 |
| 93 | TYR | 352 | PHE | 0.000 | 0.693 | -0.693 | 0.693 |
| 211 | LYS | 218 | ASP | 6.741 | 6.050 | 0.691 | 0.691 |
| 158 | PHE | 241 | PHE | 0.934 | 1.621 | -0.687 | 0.687 |
| 298 | ILE | 299 | HIS | 0.687 | 0.000 | 0.687 | 0.687 |
| 268 | SER | 274 | ASP | 1.348 | 0.663 | 0.686 | 0.686 |
| 160 | LEU | 287 | VAL | 0.000 | 0.682 | -0.682 | 0.682 |
| 335 | PRO | 349 | PHE | 0.000 | 0.677 | -0.677 | 0.677 |
| 301 | TYR | 310 | ILE | 1.115 | 0.439 | 0.676 | 0.676 |
| 236 | ILE | 240 | ILE | 0.882 | 0.208 | 0.674 | 0.674 |
| 154 | PHE | 238 | VAL | 1.511 | 0.841 | 0.670 | 0.670 |
| 105 | THR | 181 | ARG | 1.398 | 0.732 | 0.665 | 0.665 |
| 399 | LEU | 400 | PRO | 0.868 | 1.527 | -0.659 | 0.659 |
| 254 | TYR | 338 | TYR | 0.655 | 0.000 | 0.655 | 0.655 |
| 226 | PRO | 228 | TRP | 1.718 | 2.372 | -0.654 | 0.654 |
| 231 | GLU | 235 | LYS | 5.339 | 4.686 | 0.653 | 0.653 |
| 133 | GLY | 216 | SER | 1.734 | 1.081 | 0.652 | 0.652 |
| 111 | ASN | 194 | TRP | 3.674 | 4.320 | -0.645 | 0.645 |
| 153 | MET | 242 | ALA | 0.310 | 0.944 | -0.635 | 0.635 |
| 6 | ALA | 7 | PRO | 0.310 | 0.940 | -0.630 | 0.630 |
| 130 | TYR | 317 | THR | 0.627 | 0.000 | 0.627 | 0.627 |
| 290 | VAL | 330 | ASN | 1.341 | 1.962 | -0.621 | 0.621 |
| 158 | PHE | 197 | SER | 1.656 | 1.037 | 0.619 | 0.619 |
| 73 | ILE | 321 | HIS | 2.753 | 2.135 | 0.618 | 0.618 |
| 81 | CYS | 120 | THR | 2.780 | 2.164 | 0.616 | 0.616 |
| 329 | THR | 333 | LEU | 0.911 | 0.298 | 0.613 | 0.613 |
| 85 | LEU | 117 | ALA | 0.869 | 1.481 | -0.612 | 0.612 |
| 88 | ASN | 331 | SER | 1.931 | 2.540 | -0.608 | 0.608 |
| 264 | VAL | 266 | MET | 0.608 | 0.000 | 0.608 | 0.608 |
| 169 | ILE | 177 | ALA | 2.245 | 1.639 | 0.605 | 0.605 |
| 109 | ILE | 339 | ALA | 0.604 | 0.000 | 0.604 | 0.604 |
| 112 | LEU | 334 | ASN | 2.613 | 2.010 | 0.603 | 0.603 |
| 122 | THR | 145 | VAL | 1.413 | 2.012 | -0.599 | 0.599 |
| 239 | PHE | 244 | ILE | 6.034 | 6.631 | -0.597 | 0.597 |
| 174 | PRO | 267 | LEU | 0.000 | 0.594 | -0.594 | 0.594 |
| 114 | LEU | 118 | LEU | 0.818 | 0.226 | 0.592 | 0.592 |
| 225 | HIS | 227 | THR | 0.000 | 0.591 | -0.591 | 0.591 |
| 67 | MET | 71 | ILE | 0.591 | 0.000 | 0.591 | 0.591 |
| 80 | VAL | 325 | ALA | 0.584 | 0.000 | 0.584 | 0.584 |
| 160 | LEU | 330 | ASN | 0.582 | 0.000 | 0.582 | 0.582 |
| 238 | VAL | 299 | HIS | 0.845 | 0.266 | 0.580 | 0.580 |
| 170 | ALA | 177 | ALA | 1.136 | 0.562 | 0.574 | 0.574 |
| 153 | MET | 157 | ILE | 0.572 | 0.000 | 0.572 | 0.572 |
| 142 | CYS | 209 | THR | 1.192 | 1.763 | -0.571 | 0.571 |
| 240 | ILE | 241 | PHE | 0.173 | 0.739 | -0.566 | 0.566 |
| 277 | LEU | 281 | THR | 0.560 | 0.000 | 0.560 | 0.560 |
| 106 | ASN | 109 | ILE | 0.066 | 0.621 | -0.556 | 0.556 |
| 257 | MET | 261 | LEU | 0.570 | 0.015 | 0.555 | 0.555 |
| 135 | TRP | 210 | THR | 0.664 | 1.217 | -0.553 | 0.553 |
| 104 | ALA | 183 | PRO | 0.968 | 0.415 | 0.553 | 0.553 |
| 92 | MET | 114 | LEU | 1.836 | 2.389 | -0.553 | 0.553 |
| 298 | ILE | 320 | TRP | 0.000 | 0.553 | -0.553 | 0.553 |
| 122 | THR | 148 | ILE | 1.140 | 1.691 | -0.551 | 0.551 |
| 261 | LEU | 280 | ILE | 0.546 | 0.000 | 0.546 | 0.546 |
| 95 | ILE | 101 | MET | 1.419 | 0.877 | 0.542 | 0.542 |
| 349 | PHE | 353 | CYS | 0.540 | 0.000 | 0.540 | 0.540 |
| 167 | ARG | 257 | MET | 1.502 | 2.040 | -0.538 | 0.538 |
| 310 | ILE | 316 | GLN | 1.464 | 0.932 | 0.532 | 0.532 |
| 134 | THR | 217 | ILE | 6.207 | 6.729 | -0.522 | 0.522 |
| 245 | MET | 248 | LEU | 0.521 | 0.000 | 0.521 | 0.521 |
| 120 | THR | 331 | SER | 0.139 | 0.658 | -0.520 | 0.520 |
| 397 | ALA | 398 | PRO | 0.458 | 0.974 | -0.516 | 0.516 |
| 213 | ARG | 214 | GLN | 0.516 | 0.000 | 0.516 | 0.516 |
| 33 | ASN | 63 | GLY | 0.512 | 0.000 | 0.512 | 0.512 |
| 315 | PHE | 319 | SER | 0.000 | 0.509 | -0.509 | 0.509 |
| 239 | PHE | 300 | ILE | 0.000 | 0.508 | -0.508 | 0.508 |
| 108 | TYR | 186 | ALA | 4.618 | 5.124 | -0.506 | 0.506 |
| 142 | CYS | 219 | CYS | 6.652 | 7.157 | -0.506 | 0.506 |
| 143 | LYS | 206 | PHE | 2.312 | 2.812 | -0.500 | 0.500 |
| 270 | SER | 273 | LYS | 0.725 | 1.225 | -0.500 | 0.500 |
| 88 | ASN | 120 | THR | 0.496 | 0.000 | 0.496 | 0.496 |
| 101 | MET | 348 | CYS | 0.000 | 0.495 | -0.495 | 0.495 |
| 351 | GLU | 352 | PHE | 0.494 | 0.000 | 0.494 | 0.494 |
| 225 | HIS | 230 | TRP | 0.754 | 0.269 | 0.485 | 0.485 |
| 154 | PHE | 158 | PHE | 2.397 | 1.913 | 0.484 | 0.484 |
| 211 | LYS | 216 | SER | 0.886 | 0.404 | 0.482 | 0.482 |
| 244 | ILE | 245 | MET | 0.477 | 0.000 | 0.477 | 0.477 |
| 213 | ARG | 216 | SER | 0.000 | 0.475 | -0.475 | 0.475 |
| 164 | SER | 249 | ILE | 0.474 | 0.000 | 0.474 | 0.474 |
| 103 | THR | 106 | ASN | 4.443 | 3.969 | 0.474 | 0.474 |
| 226 | PRO | 230 | TRP | 0.473 | 0.000 | 0.473 | 0.473 |
| 104 | ALA | 182 | THR | 1.001 | 0.528 | 0.473 | 0.473 |
| 11 | SER | 12 | ASN | 0.000 | 0.472 | -0.472 | 0.472 |
| 162 | THR | 189 | ILE | 0.980 | 1.451 | -0.472 | 0.472 |
| 164 | SER | 288 | VAL | 0.000 | 0.464 | -0.464 | 0.464 |
| 209 | THR | 220 | THR | 6.144 | 6.607 | -0.462 | 0.462 |
| 95 | ILE | 345 | PHE | 2.151 | 1.690 | 0.461 | 0.461 |
| 227 | THR | 231 | GLU | 0.136 | 0.586 | -0.451 | 0.451 |
| 202 | LEU | 205 | MET | 0.000 | 0.445 | -0.445 | 0.445 |
| 112 | LEU | 287 | VAL | 0.000 | 0.442 | -0.442 | 0.442 |
| 283 | MET | 338 | TYR | 0.000 | 0.441 | -0.441 | 0.441 |
| 207 | MET | 221 | LEU | 2.330 | 2.771 | -0.441 | 0.441 |
| 172 | CYS | 256 | LEU | 0.756 | 0.316 | 0.440 | 0.440 |
| 80 | VAL | 120 | THR | 0.273 | 0.706 | -0.433 | 0.433 |
| 84 | GLY | 332 | CYS | 2.842 | 2.411 | 0.432 | 0.432 |
| 266 | MET | 274 | ASP | 0.000 | 0.430 | -0.430 | 0.430 |
| 143 | LYS | 209 | THR | 0.423 | 0.000 | 0.423 | 0.423 |
| 262 | LYS | 277 | LEU | 0.422 | 0.000 | 0.422 | 0.422 |
| 112 | LEU | 163 | MET | 0.419 | 0.000 | 0.419 | 0.419 |
| 179 | ASP | 180 | PHE | 0.000 | 0.419 | -0.419 | 0.419 |
| 86 | PHE | 90 | LEU | 0.898 | 0.483 | 0.416 | 0.416 |
| 177 | ALA | 181 | ARG | 0.539 | 0.953 | -0.414 | 0.414 |
| 287 | VAL | 337 | LEU | 0.226 | 0.639 | -0.413 | 0.413 |
| 189 | ILE | 193 | ASN | 0.412 | 0.000 | 0.412 | 0.412 |
| 334 | ASN | 338 | TYR | 1.705 | 2.117 | -0.412 | 0.412 |
| 244 | ILE | 248 | LEU | 0.274 | 0.685 | -0.411 | 0.411 |
| 251 | THR | 288 | VAL | 0.407 | 0.000 | 0.407 | 0.407 |
| 118 | LEU | 194 | TRP | 0.194 | 0.598 | -0.404 | 0.404 |
| 334 | ASN | 337 | LEU | 0.000 | 0.402 | -0.402 | 0.402 |
| 190 | ASN | 193 | ASN | 0.400 | 0.000 | 0.400 | 0.400 |
| 73 | ILE | 318 | VAL | 0.399 | 0.000 | 0.399 | 0.399 |
| 281 | THR | 285 | LEU | 0.395 | 0.000 | 0.395 | 0.395 |
| 77 | TYR | 126 | GLN | 0.443 | 0.835 | -0.392 | 0.392 |
| 81 | CYS | 123 | LEU | 1.573 | 1.181 | 0.392 | 0.392 |
| 152 | ASN | 331 | SER | 0.000 | 0.391 | -0.391 | 0.391 |
| 210 | THR | 217 | ILE | 1.212 | 0.821 | 0.391 | 0.391 |
| 146 | ILE | 204 | VAL | 1.751 | 1.362 | 0.389 | 0.389 |
| 171 | VAL | 281 | THR | 0.000 | 0.388 | -0.388 | 0.388 |
| 164 | SER | 284 | VAL | 0.000 | 0.388 | -0.388 | 0.388 |
| 126 | GLN | 324 | ILE | 0.387 | 0.000 | 0.387 | 0.387 |
| 141 | LEU | 145 | VAL | 0.687 | 0.302 | 0.385 | 0.385 |
| 19 | TYR | 20 | SER | 0.384 | 0.000 | 0.384 | 0.384 |
| 229 | TYR | 233 | LEU | 0.643 | 0.260 | 0.383 | 0.383 |
| 290 | VAL | 337 | LEU | 1.554 | 1.175 | 0.379 | 0.379 |
| 36 | HIS | 61 | PRO | 0.000 | 0.379 | -0.379 | 0.379 |
| 128 | VAL | 137 | PHE | 2.225 | 1.847 | 0.378 | 0.378 |
| 85 | LEU | 121 | SER | 0.586 | 0.959 | -0.373 | 0.373 |
| 294 | CYS | 327 | GLY | 1.272 | 1.642 | -0.370 | 0.370 |
| 265 | ARG | 278 | ARG | 0.000 | 0.365 | -0.365 | 0.365 |
| 120 | THR | 123 | LEU | 0.088 | 0.450 | -0.362 | 0.362 |
| 150 | TYR | 153 | MET | 0.000 | 0.359 | -0.359 | 0.359 |
| 313 | THR | 316 | GLN | 1.131 | 0.773 | 0.359 | 0.359 |
| 164 | SER | 250 | ILE | 3.090 | 2.732 | 0.358 | 0.358 |
| 334 | ASN | 339 | ALA | 0.357 | 0.000 | 0.357 | 0.357 |
| 242 | ALA | 291 | PHE | 0.357 | 0.000 | 0.357 | 0.357 |
| 304 | ILE | 310 | ILE | 0.000 | 0.355 | -0.355 | 0.355 |
| 221 | LEU | 223 | PHE | 1.634 | 1.280 | 0.354 | 0.354 |
| 329 | THR | 332 | CYS | 0.000 | 0.354 | -0.354 | 0.354 |
| 94 | VAL | 98 | TYR | 0.429 | 0.777 | -0.348 | 0.348 |
| 35 | SER | 36 | HIS | 0.347 | 0.000 | 0.347 | 0.347 |
| 122 | THR | 123 | LEU | 0.347 | 0.000 | 0.347 | 0.347 |
| 147 | SER | 205 | MET | 4.427 | 4.091 | 0.336 | 0.336 |
| 293 | VAL | 326 | LEU | 0.000 | 0.336 | -0.336 | 0.336 |
| 221 | LEU | 234 | LEU | 0.706 | 0.371 | 0.334 | 0.334 |
| 146 | ILE | 208 | ALA | 0.858 | 1.187 | -0.329 | 0.329 |
| 349 | PHE | 354 | ILE | 0.326 | 0.000 | 0.326 | 0.326 |
| 232 | ASN | 235 | LYS | 1.550 | 1.224 | 0.326 | 0.326 |
| 145 | VAL | 149 | ASP | 0.000 | 0.322 | -0.322 | 0.322 |
| 200 | ILE | 204 | VAL | 0.759 | 0.437 | 0.322 | 0.322 |
| 69 | THR | 318 | VAL | 0.771 | 0.450 | 0.321 | 0.321 |
| 247 | VAL | 292 | ILE | 0.257 | 0.575 | -0.318 | 0.318 |
| 149 | ASP | 328 | TYR | 4.762 | 4.446 | 0.316 | 0.316 |
| 109 | ILE | 342 | ASP | 0.316 | 0.000 | 0.316 | 0.316 |
| 172 | CYS | 260 | ARG | 1.532 | 1.218 | 0.314 | 0.314 |
| 305 | LYS | 316 | GLN | 0.623 | 0.312 | 0.311 | 0.311 |
| 245 | MET | 246 | PRO | 0.877 | 1.187 | -0.311 | 0.311 |
| 65 | PRO | 317 | THR | 0.000 | 0.309 | -0.309 | 0.309 |
| 305 | LYS | 320 | TRP | 0.410 | 0.717 | -0.307 | 0.307 |
| 211 | LYS | 220 | THR | 0.192 | 0.499 | -0.307 | 0.307 |
| 105 | THR | 109 | ILE | 0.497 | 0.191 | 0.306 | 0.306 |
| 275 | ARG | 278 | ARG | 0.305 | 0.000 | 0.305 | 0.305 |
| 100 | LYS | 102 | LYS | 0.304 | 0.000 | 0.304 | 0.304 |
| 156 | SER | 331 | SER | 0.302 | 0.000 | 0.302 | 0.302 |
| 305 | LYS | 310 | ILE | 0.457 | 0.758 | -0.301 | 0.301 |
| 294 | CYS | 295 | TRP | 0.024 | 0.325 | -0.301 | 0.301 |
| 230 | TRP | 233 | LEU | 1.165 | 0.868 | 0.297 | 0.297 |
| 150 | TYR | 238 | VAL | 0.465 | 0.762 | -0.296 | 0.296 |
| 163 | MET | 254 | TYR | 0.291 | 0.000 | 0.291 | 0.291 |
| 271 | LYS | 278 | ARG | 0.291 | 0.000 | 0.291 | 0.291 |
| 155 | THR | 159 | THR | 0.289 | 0.000 | 0.289 | 0.289 |
| 29 | GLY | 231 | GLU | 1.479 | 1.191 | 0.288 | 0.288 |
| 316 | GLN | 320 | TRP | 0.408 | 0.695 | -0.288 | 0.288 |
| 182 | THR | 184 | ARG | 0.293 | 0.580 | -0.288 | 0.288 |
| 30 | SER | 32 | VAL | 0.047 | 0.334 | -0.287 | 0.287 |
| 165 | VAL | 169 | ILE | 0.959 | 0.673 | 0.286 | 0.286 |
| 108 | TYR | 180 | PHE | 0.284 | 0.000 | 0.284 | 0.284 |
| 107 | ILE | 183 | PRO | 1.393 | 1.110 | 0.283 | 0.283 |
| 32 | VAL | 33 | ASN | 0.278 | 0.000 | 0.278 | 0.278 |
| 139 | THR | 143 | LYS | 0.187 | 0.464 | -0.277 | 0.277 |
| 290 | VAL | 294 | CYS | 0.539 | 0.264 | 0.275 | 0.275 |
| 223 | PHE | 234 | LEU | 1.436 | 1.162 | 0.274 | 0.274 |
| 33 | ASN | 65 | PRO | 0.272 | 0.000 | 0.272 | 0.272 |
| 154 | PHE | 193 | ASN | 0.000 | 0.272 | -0.272 | 0.272 |
| 70 | ALA | 130 | TYR | 0.603 | 0.875 | -0.272 | 0.272 |
| 104 | ALA | 166 | ASP | 0.000 | 0.272 | -0.272 | 0.272 |
| 150 | TYR | 200 | ILE | 0.000 | 0.270 | -0.270 | 0.270 |
| 198 | SER | 203 | PRO | 0.359 | 0.627 | -0.268 | 0.268 |
| 31 | TRP | 235 | LYS | 0.000 | 0.267 | -0.267 | 0.267 |
| 146 | ILE | 221 | LEU | 0.764 | 1.031 | -0.266 | 0.266 |
| 159 | THR | 163 | MET | 0.324 | 0.590 | -0.266 | 0.266 |
| 257 | MET | 281 | THR | 0.000 | 0.265 | -0.265 | 0.265 |
| 235 | LYS | 303 | ILE | 0.082 | 0.346 | -0.264 | 0.264 |
| 241 | PHE | 245 | MET | 0.040 | 0.304 | -0.264 | 0.264 |
| 77 | TYR | 130 | TYR | 0.000 | 0.262 | -0.262 | 0.262 |
| 333 | LEU | 337 | LEU | 0.262 | 0.000 | 0.262 | 0.262 |
| 119 | ALA | 331 | SER | 0.000 | 0.260 | -0.260 | 0.260 |
| 294 | CYS | 333 | LEU | 0.000 | 0.259 | -0.259 | 0.259 |
| 169 | ILE | 176 | LYS | 0.258 | 0.000 | 0.258 | 0.258 |
| 387 | HIS | 390 | GLU | 0.256 | 0.000 | 0.256 | 0.256 |
| 105 | THR | 167 | ARG | 0.000 | 0.253 | -0.253 | 0.253 |
| 85 | LEU | 89 | PHE | 0.654 | 0.907 | -0.252 | 0.252 |
| 165 | VAL | 249 | ILE | 0.421 | 0.170 | 0.251 | 0.251 |
| 74 | MET | 130 | TYR | 0.250 | 0.000 | 0.250 | 0.250 |
| 167 | ARG | 170 | ALA | 0.000 | 0.249 | -0.249 | 0.249 |
| 264 | VAL | 267 | LEU | 0.000 | 0.249 | -0.249 | 0.249 |
| 297 | PRO | 326 | LEU | 0.505 | 0.257 | 0.248 | 0.248 |
| 81 | CYS | 124 | PRO | 1.274 | 1.026 | 0.247 | 0.247 |
| 168 | TYR | 172 | CYS | 3.027 | 3.272 | -0.244 | 0.244 |
| 241 | PHE | 246 | PRO | 3.004 | 2.760 | 0.244 | 0.244 |
| 67 | MET | 131 | LEU | 0.000 | 0.243 | -0.243 | 0.243 |
| 280 | ILE | 400 | PRO | 0.242 | 0.000 | 0.242 | 0.242 |
| 139 | THR | 210 | THR | 6.373 | 6.132 | 0.241 | 0.241 |
| 32 | VAL | 216 | SER | 0.240 | 0.000 | 0.240 | 0.240 |
| 301 | TYR | 305 | LYS | 0.302 | 0.061 | 0.240 | 0.240 |
| 171 | VAL | 172 | CYS | 0.091 | 0.331 | -0.240 | 0.240 |
| 68 | ILE | 72 | THR | 0.388 | 0.148 | 0.240 | 0.240 |
| 182 | THR | 183 | PRO | 0.648 | 0.888 | -0.240 | 0.240 |
| 84 | GLY | 331 | SER | 0.000 | 0.239 | -0.239 | 0.239 |
| 27 | SER | 28 | PRO | 0.286 | 0.523 | -0.237 | 0.237 |
| 204 | VAL | 207 | MET | 0.237 | 0.000 | 0.237 | 0.237 |
| 108 | TYR | 162 | THR | 2.233 | 2.470 | -0.237 | 0.237 |
| 105 | THR | 284 | VAL | 0.000 | 0.235 | -0.235 | 0.235 |
| 126 | GLN | 149 | ASP | 2.335 | 2.570 | -0.235 | 0.235 |
| 172 | CYS | 173 | HIS | 1.426 | 1.192 | 0.233 | 0.233 |
| 235 | LYS | 306 | ALA | 0.568 | 0.801 | -0.233 | 0.233 |
| 146 | ILE | 150 | TYR | 0.857 | 0.629 | 0.228 | 0.228 |
| 258 | ILE | 285 | LEU | 0.225 | 0.000 | 0.225 | 0.225 |
| 69 | THR | 73 | ILE | 0.537 | 0.760 | -0.223 | 0.223 |
| 247 | VAL | 251 | THR | 0.495 | 0.272 | 0.223 | 0.223 |
| 157 | ILE | 250 | ILE | 0.000 | 0.221 | -0.221 | 0.221 |
| 65 | PRO | 321 | HIS | 0.000 | 0.219 | -0.219 | 0.219 |
| 166 | ASP | 167 | ARG | 0.000 | 0.217 | -0.217 | 0.217 |
| 164 | SER | 257 | MET | 0.000 | 0.217 | -0.217 | 0.217 |
| 372 | THR | 373 | ARG | 0.213 | 0.000 | 0.213 | 0.213 |
| 209 | THR | 210 | THR | 0.000 | 0.213 | -0.213 | 0.213 |
| 203 | PRO | 207 | MET | 0.431 | 0.221 | 0.210 | 0.210 |
| 135 | TRP | 145 | VAL | 0.802 | 0.592 | 0.210 | 0.210 |
| 153 | MET | 154 | PHE | 1.275 | 1.483 | -0.209 | 0.209 |
| 354 | ILE | 355 | PRO | 0.420 | 0.215 | 0.206 | 0.206 |
| 103 | THR | 105 | THR | 0.114 | 0.318 | -0.204 | 0.204 |
| 314 | THR | 318 | VAL | 0.000 | 0.199 | -0.199 | 0.199 |
| 74 | MET | 78 | SER | 0.000 | 0.198 | -0.198 | 0.198 |
| 180 | PHE | 181 | ARG | 0.197 | 0.000 | 0.197 | 0.197 |
| 147 | SER | 201 | GLY | 2.718 | 2.521 | 0.196 | 0.196 |
| 155 | THR | 156 | SER | 0.000 | 0.195 | -0.195 | 0.195 |
| 91 | VAL | 95 | ILE | 0.822 | 0.628 | 0.195 | 0.195 |
| 73 | ILE | 317 | THR | 0.195 | 0.000 | 0.195 | 0.195 |
| 108 | TYR | 166 | ASP | 1.521 | 1.327 | 0.194 | 0.194 |
| 41 | LEU | 42 | SER | 0.193 | 0.000 | 0.193 | 0.193 |
| 239 | PHE | 240 | ILE | 0.081 | 0.272 | -0.191 | 0.191 |
| 66 | SER | 69 | THR | 2.376 | 2.185 | 0.190 | 0.190 |
| 144 | ILE | 148 | ILE | 1.012 | 0.824 | 0.188 | 0.188 |
| 295 | TRP | 298 | ILE | 0.487 | 0.674 | -0.188 | 0.188 |
| 157 | ILE | 242 | ALA | 3.043 | 3.227 | -0.184 | 0.184 |
| 169 | ILE | 181 | ARG | 0.000 | 0.183 | -0.183 | 0.183 |
| 267 | LEU | 277 | LEU | 0.881 | 0.699 | 0.182 | 0.182 |
| 297 | PRO | 323 | CYS | 1.340 | 1.160 | 0.181 | 0.181 |
| 111 | ASN | 155 | THR | 0.000 | 0.179 | -0.179 | 0.179 |
| 159 | THR | 190 | ASN | 0.179 | 0.000 | 0.179 | 0.179 |
| 92 | MET | 113 | ALA | 1.330 | 1.508 | -0.178 | 0.178 |
| 99 | THR | 100 | LYS | 0.000 | 0.178 | -0.178 | 0.178 |
| 286 | VAL | 337 | LEU | 0.533 | 0.356 | 0.177 | 0.177 |
| 243 | PHE | 244 | ILE | 1.284 | 1.107 | 0.176 | 0.176 |
| 348 | CYS | 352 | PHE | 0.175 | 0.000 | 0.175 | 0.175 |
| 358 | SER | 359 | ASN | 0.174 | 0.000 | 0.174 | 0.174 |
| 337 | LEU | 341 | LEU | 0.168 | 0.342 | -0.174 | 0.174 |
| 76 | LEU | 321 | HIS | 0.174 | 0.000 | 0.174 | 0.174 |
| 105 | THR | 283 | MET | 0.000 | 0.173 | -0.173 | 0.173 |
| 27 | SER | 211 | LYS | 0.000 | 0.173 | -0.173 | 0.173 |
| 302 | VAL | 320 | TRP | 1.117 | 1.289 | -0.172 | 0.172 |
| 250 | ILE | 288 | VAL | 0.670 | 0.841 | -0.172 | 0.172 |
| 292 | ILE | 297 | PRO | 0.218 | 0.047 | 0.171 | 0.171 |
| 105 | THR | 163 | MET | 0.000 | 0.170 | -0.170 | 0.170 |
| 172 | CYS | 257 | MET | 0.628 | 0.458 | 0.170 | 0.170 |
| 280 | ILE | 283 | MET | 0.000 | 0.169 | -0.169 | 0.169 |
| 70 | ALA | 131 | LEU | 0.000 | 0.169 | -0.169 | 0.169 |
| 211 | LYS | 217 | ILE | 1.685 | 1.854 | -0.169 | 0.169 |
| 34 | LEU | 37 | LEU | 0.168 | 0.000 | 0.168 | 0.168 |
| 251 | THR | 292 | ILE | 0.168 | 0.000 | 0.168 | 0.168 |
| 43 | ASP | 45 | CYS | 0.000 | 0.167 | -0.167 | 0.167 |
| 294 | CYS | 330 | ASN | 3.086 | 2.921 | 0.165 | 0.165 |
| 65 | PRO | 69 | THR | 0.600 | 0.764 | -0.164 | 0.164 |
| 31 | TRP | 32 | VAL | 0.000 | 0.161 | -0.161 | 0.161 |
| 109 | ILE | 345 | PHE | 0.965 | 0.805 | 0.161 | 0.161 |
| 146 | ILE | 220 | THR | 1.523 | 1.684 | -0.160 | 0.160 |
| 286 | VAL | 290 | VAL | 0.368 | 0.208 | 0.160 | 0.160 |
| 146 | ILE | 219 | CYS | 2.089 | 1.930 | 0.159 | 0.159 |
| 128 | VAL | 132 | MET | 1.092 | 1.250 | -0.159 | 0.159 |
| 321 | HIS | 324 | ILE | 0.158 | 0.000 | 0.158 | 0.158 |
| 80 | VAL | 85 | LEU | 0.000 | 0.158 | -0.158 | 0.158 |
| 30 | SER | 221 | LEU | 0.000 | 0.157 | -0.157 | 0.157 |
| 80 | VAL | 123 | LEU | 1.073 | 1.229 | -0.155 | 0.155 |
| 294 | CYS | 323 | CYS | 0.000 | 0.152 | -0.152 | 0.152 |
| 169 | ILE | 174 | PRO | 0.553 | 0.401 | 0.152 | 0.152 |
| 375 | HIS | 377 | SER | 0.000 | 0.151 | -0.151 | 0.151 |
| 87 | GLY | 340 | PHE | 0.150 | 0.000 | 0.150 | 0.150 |
| 135 | TRP | 218 | ASP | 0.021 | 0.171 | -0.150 | 0.150 |
| 84 | GLY | 120 | THR | 0.955 | 0.806 | 0.149 | 0.149 |
| 160 | LEU | 163 | MET | 0.000 | 0.149 | -0.149 | 0.149 |
| 29 | GLY | 223 | PHE | 0.000 | 0.149 | -0.149 | 0.149 |
| 185 | ASN | 188 | ILE | 0.000 | 0.148 | -0.148 | 0.148 |
| 284 | VAL | 288 | VAL | 0.060 | 0.208 | -0.147 | 0.147 |
| 157 | ILE | 247 | VAL | 0.000 | 0.147 | -0.147 | 0.147 |
| 169 | ILE | 173 | HIS | 0.145 | 0.000 | 0.145 | 0.145 |
| 233 | LEU | 237 | CYS | 0.555 | 0.699 | -0.145 | 0.145 |
| 157 | ILE | 161 | CYS | 0.144 | 0.000 | 0.144 | 0.144 |
| 226 | PRO | 229 | TYR | 0.587 | 0.443 | 0.143 | 0.143 |
| 130 | TYR | 324 | ILE | 0.000 | 0.143 | -0.143 | 0.143 |
| 208 | ALA | 221 | LEU | 1.885 | 1.743 | 0.142 | 0.142 |
| 240 | ILE | 244 | ILE | 0.000 | 0.142 | -0.142 | 0.142 |
| 110 | PHE | 114 | LEU | 0.161 | 0.020 | 0.141 | 0.141 |
| 303 | ILE | 307 | LEU | 0.909 | 0.768 | 0.141 | 0.141 |
| 142 | CYS | 146 | ILE | 0.606 | 0.466 | 0.141 | 0.141 |
| 115 | ALA | 155 | THR | 1.180 | 1.040 | 0.140 | 0.140 |
| 223 | PHE | 230 | TRP | 3.211 | 3.070 | 0.140 | 0.140 |
| 324 | ILE | 328 | TYR | 1.228 | 1.365 | -0.137 | 0.137 |
| 237 | CYS | 242 | ALA | 0.127 | 0.263 | -0.136 | 0.136 |
| 153 | MET | 291 | PHE | 0.000 | 0.135 | -0.135 | 0.135 |
| 16 | ALA | 17 | LEU | 0.134 | 0.000 | 0.134 | 0.134 |
| 290 | VAL | 333 | LEU | 0.640 | 0.507 | 0.134 | 0.134 |
| 69 | THR | 130 | TYR | 0.133 | 0.000 | 0.133 | 0.133 |
| 31 | TRP | 126 | GLN | 0.132 | 0.000 | 0.132 | 0.132 |
| 238 | VAL | 243 | PHE | 0.507 | 0.639 | -0.132 | 0.132 |
| 232 | ASN | 306 | ALA | 0.376 | 0.507 | -0.132 | 0.132 |
| 168 | TYR | 256 | LEU | 2.595 | 2.727 | -0.131 | 0.131 |
| 89 | PHE | 92 | MET | 0.128 | 0.000 | 0.128 | 0.128 |
| 80 | VAL | 332 | CYS | 2.887 | 2.759 | 0.128 | 0.128 |
| 86 | PHE | 352 | PHE | 0.000 | 0.128 | -0.128 | 0.128 |
| 294 | CYS | 329 | THR | 0.127 | 0.000 | 0.127 | 0.127 |
| 150 | TYR | 154 | PHE | 0.000 | 0.125 | -0.125 | 0.125 |
| 270 | SER | 272 | GLU | 0.435 | 0.560 | -0.125 | 0.125 |
| 137 | PHE | 141 | LEU | 2.350 | 2.473 | -0.123 | 0.123 |
| 339 | ALA | 340 | PHE | 0.141 | 0.019 | 0.122 | 0.122 |
| 140 | ILE | 144 | ILE | 0.414 | 0.534 | -0.120 | 0.120 |
| 151 | TYR | 156 | SER | 0.000 | 0.119 | -0.119 | 0.119 |
| 127 | SER | 128 | VAL | 0.000 | 0.117 | -0.117 | 0.117 |
| 163 | MET | 167 | ARG | 0.115 | 0.000 | 0.115 | 0.115 |
| 21 | SER | 22 | CYS | 0.115 | 0.000 | 0.115 | 0.115 |
| 331 | SER | 334 | ASN | 0.114 | 0.000 | 0.114 | 0.114 |
| 80 | VAL | 328 | TYR | 1.364 | 1.251 | 0.113 | 0.113 |
| 319 | SER | 323 | CYS | 0.112 | 0.000 | 0.112 | 0.112 |
| 159 | THR | 162 | THR | 0.000 | 0.109 | -0.109 | 0.109 |
| 388 | GLN | 389 | LEU | 0.000 | 0.108 | -0.108 | 0.108 |
| 311 | PRO | 313 | THR | 0.000 | 0.108 | -0.108 | 0.108 |
| 186 | ALA | 190 | ASN | 0.108 | 0.000 | 0.108 | 0.108 |
| 143 | LYS | 208 | ALA | 6.435 | 6.539 | -0.104 | 0.104 |
| 130 | TYR | 321 | HIS | 5.654 | 5.551 | 0.104 | 0.104 |
| 60 | PRO | 61 | PRO | 0.565 | 0.669 | -0.104 | 0.104 |
| 184 | ARG | 188 | ILE | 0.313 | 0.210 | 0.103 | 0.103 |
| 29 | GLY | 219 | CYS | 0.102 | 0.000 | 0.102 | 0.102 |
| 31 | TRP | 221 | LEU | 0.000 | 0.101 | -0.101 | 0.101 |
| 336 | VAL | 340 | PHE | 0.966 | 1.065 | -0.100 | 0.100 |
| 132 | MET | 134 | THR | 0.523 | 0.623 | -0.099 | 0.099 |
| 311 | PRO | 316 | GLN | 0.859 | 0.956 | -0.097 | 0.097 |
| 283 | MET | 287 | VAL | 0.000 | 0.097 | -0.097 | 0.097 |
| 96 | VAL | 110 | PHE | 0.785 | 0.881 | -0.096 | 0.096 |
| 178 | LEU | 179 | ASP | 0.000 | 0.096 | -0.096 | 0.096 |
| 152 | ASN | 155 | THR | 0.095 | 0.000 | 0.095 | 0.095 |
| 79 | ILE | 84 | GLY | 0.000 | 0.095 | -0.095 | 0.095 |
| 103 | THR | 183 | PRO | 0.008 | 0.102 | -0.094 | 0.094 |
| 91 | VAL | 335 | PRO | 1.204 | 1.110 | 0.093 | 0.093 |
| 208 | ALA | 220 | THR | 1.941 | 2.033 | -0.092 | 0.092 |
| 209 | THR | 211 | LYS | 0.092 | 0.000 | 0.092 | 0.092 |
| 142 | CYS | 208 | ALA | 0.168 | 0.077 | 0.091 | 0.091 |
| 105 | THR | 342 | ASP | 0.089 | 0.000 | 0.089 | 0.089 |
| 143 | LYS | 207 | MET | 0.000 | 0.089 | -0.089 | 0.089 |
| 123 | LEU | 126 | GLN | 0.004 | 0.093 | -0.088 | 0.088 |
| 88 | ASN | 335 | PRO | 4.048 | 4.134 | -0.086 | 0.086 |
| 320 | TRP | 321 | HIS | 1.445 | 1.359 | 0.085 | 0.085 |
| 228 | TRP | 229 | TYR | 2.179 | 2.094 | 0.085 | 0.085 |
| 121 | SER | 122 | THR | 0.164 | 0.249 | -0.085 | 0.085 |
| 282 | ARG | 286 | VAL | 0.000 | 0.085 | -0.085 | 0.085 |
| 151 | TYR | 205 | MET | 0.000 | 0.084 | -0.084 | 0.084 |
| 258 | ILE | 262 | LYS | 0.876 | 0.960 | -0.084 | 0.084 |
| 184 | ARG | 185 | ASN | 0.000 | 0.081 | -0.081 | 0.081 |
| 228 | TRP | 232 | ASN | 0.113 | 0.192 | -0.080 | 0.080 |
| 79 | ILE | 83 | VAL | 0.144 | 0.223 | -0.079 | 0.079 |
| 104 | ALA | 186 | ALA | 1.869 | 1.944 | -0.076 | 0.076 |
| 104 | ALA | 181 | ARG | 1.061 | 1.137 | -0.076 | 0.076 |
| 210 | THR | 219 | CYS | 0.075 | 0.000 | 0.075 | 0.075 |
| 90 | LEU | 93 | TYR | 0.000 | 0.074 | -0.074 | 0.074 |
| 256 | LEU | 259 | LEU | 0.225 | 0.152 | 0.073 | 0.073 |
| 43 | ASP | 44 | PRO | 0.753 | 0.682 | 0.072 | 0.072 |
| 279 | ARG | 282 | ARG | 0.222 | 0.293 | -0.071 | 0.071 |
| 25 | ALA | 26 | PRO | 0.574 | 0.644 | -0.070 | 0.070 |
| 210 | THR | 218 | ASP | 2.699 | 2.629 | 0.069 | 0.069 |
| 296 | THR | 297 | PRO | 1.093 | 1.025 | 0.068 | 0.068 |
| 301 | TYR | 323 | CYS | 0.481 | 0.549 | -0.068 | 0.068 |
| 340 | PHE | 341 | LEU | 0.000 | 0.066 | -0.066 | 0.066 |
| 109 | ILE | 163 | MET | 0.560 | 0.626 | -0.066 | 0.066 |
| 342 | ASP | 343 | GLU | 0.065 | 0.000 | 0.065 | 0.065 |
| 188 | ILE | 192 | CYS | 0.200 | 0.265 | -0.065 | 0.065 |
| 374 | ASP | 375 | HIS | 0.063 | 0.000 | 0.063 | 0.063 |
| 51 | ASP | 52 | LEU | 1.211 | 1.148 | 0.063 | 0.063 |
| 99 | THR | 348 | CYS | 0.063 | 0.000 | 0.063 | 0.063 |
| 173 | HIS | 176 | LYS | 0.267 | 0.329 | -0.061 | 0.061 |
| 59 | CYS | 60 | PRO | 0.504 | 0.445 | 0.059 | 0.059 |
| 207 | MET | 220 | THR | 0.432 | 0.374 | 0.058 | 0.058 |
| 291 | PHE | 292 | ILE | 0.058 | 0.000 | 0.058 | 0.058 |
| 204 | VAL | 234 | LEU | 0.000 | 0.058 | -0.058 | 0.058 |
| 89 | PHE | 117 | ALA | 0.057 | 0.000 | 0.057 | 0.057 |
| 135 | TRP | 142 | CYS | 5.433 | 5.378 | 0.055 | 0.055 |
| 23 | SER | 24 | PRO | 0.398 | 0.344 | 0.054 | 0.054 |
| 121 | SER | 148 | ILE | 0.052 | 0.000 | 0.052 | 0.052 |
| 81 | CYS | 85 | LEU | 1.025 | 0.973 | 0.052 | 0.052 |
| 191 | VAL | 195 | ILE | 0.774 | 0.723 | 0.051 | 0.051 |
| 264 | VAL | 278 | ARG | 0.000 | 0.050 | -0.050 | 0.050 |
| 71 | ILE | 131 | LEU | 0.000 | 0.049 | -0.049 | 0.049 |
| 237 | CYS | 241 | PHE | 0.427 | 0.379 | 0.049 | 0.049 |
| 35 | SER | 312 | GLU | 0.341 | 0.295 | 0.046 | 0.046 |
| 338 | TYR | 346 | LYS | 0.000 | 0.046 | -0.046 | 0.046 |
| 123 | LEU | 124 | PRO | 0.837 | 0.791 | 0.046 | 0.046 |
| 238 | VAL | 242 | ALA | 0.218 | 0.173 | 0.045 | 0.045 |
| 105 | THR | 106 | ASN | 0.000 | 0.045 | -0.045 | 0.045 |
| 313 | THR | 315 | PHE | 0.465 | 0.509 | -0.044 | 0.044 |
| 91 | VAL | 109 | ILE | 0.659 | 0.618 | 0.041 | 0.041 |
| 35 | SER | 64 | SER | 0.000 | 0.041 | -0.041 | 0.041 |
| 157 | ILE | 160 | LEU | 0.000 | 0.040 | -0.040 | 0.040 |
| 209 | THR | 219 | CYS | 1.077 | 1.114 | -0.037 | 0.037 |
| 92 | MET | 117 | ALA | 0.040 | 0.003 | 0.037 | 0.037 |
| 128 | VAL | 134 | THR | 0.104 | 0.067 | 0.037 | 0.037 |
| 31 | TRP | 149 | ASP | 0.037 | 0.000 | 0.037 | 0.037 |
| 142 | CYS | 220 | THR | 0.428 | 0.465 | -0.037 | 0.037 |
| 76 | LEU | 80 | VAL | 0.103 | 0.140 | -0.036 | 0.036 |
| 252 | VAL | 256 | LEU | 0.634 | 0.670 | -0.036 | 0.036 |
| 129 | ASN | 217 | ILE | 0.000 | 0.035 | -0.035 | 0.035 |
| 220 | THR | 222 | THR | 0.028 | 0.063 | -0.034 | 0.034 |
| 104 | ALA | 108 | TYR | 0.033 | 0.000 | 0.033 | 0.033 |
| 90 | LEU | 94 | VAL | 0.170 | 0.203 | -0.033 | 0.033 |
| 283 | MET | 284 | VAL | 0.000 | 0.031 | -0.031 | 0.031 |
| 294 | CYS | 326 | LEU | 4.948 | 4.979 | -0.031 | 0.031 |
| 234 | LEU | 238 | VAL | 0.465 | 0.434 | 0.031 | 0.031 |
| 72 | THR | 73 | ILE | 0.000 | 0.030 | -0.030 | 0.030 |
| 93 | TYR | 98 | TYR | 0.030 | 0.000 | 0.030 | 0.030 |
| 307 | LEU | 308 | VAL | 0.271 | 0.301 | -0.029 | 0.029 |
| 64 | SER | 65 | PRO | 0.581 | 0.609 | -0.028 | 0.028 |
| 167 | ARG | 171 | VAL | 0.000 | 0.027 | -0.027 | 0.027 |
| 337 | LEU | 342 | ASP | 0.000 | 0.027 | -0.027 | 0.027 |
| 69 | THR | 72 | THR | 0.000 | 0.026 | -0.026 | 0.026 |
| 320 | TRP | 324 | ILE | 3.090 | 3.064 | 0.026 | 0.026 |
| 250 | ILE | 255 | GLY | 0.025 | 0.000 | 0.025 | 0.025 |
| 116 | ASP | 330 | ASN | 0.000 | 0.025 | -0.025 | 0.025 |
| 76 | LEU | 77 | TYR | 0.000 | 0.025 | -0.025 | 0.025 |
| 156 | SER | 160 | LEU | 0.024 | 0.000 | 0.024 | 0.024 |
| 179 | ASP | 185 | ASN | 0.423 | 0.446 | -0.024 | 0.024 |
| 246 | PRO | 250 | ILE | 0.023 | 0.000 | 0.023 | 0.023 |
| 61 | PRO | 64 | SER | 0.000 | 0.022 | -0.022 | 0.022 |
| 200 | ILE | 234 | LEU | 0.784 | 0.763 | 0.021 | 0.021 |
| 298 | ILE | 302 | VAL | 0.378 | 0.400 | -0.021 | 0.021 |
| 112 | LEU | 338 | TYR | 1.293 | 1.274 | 0.020 | 0.020 |
| 249 | ILE | 253 | CYS | 0.325 | 0.306 | 0.019 | 0.019 |
| 202 | LEU | 203 | PRO | 0.890 | 0.872 | 0.018 | 0.018 |
| 292 | ILE | 296 | THR | 1.036 | 1.018 | 0.018 | 0.018 |
| 165 | VAL | 180 | PHE | 0.017 | 0.000 | 0.017 | 0.017 |
| 316 | GLN | 317 | THR | 0.623 | 0.640 | -0.017 | 0.017 |
| 91 | VAL | 113 | ALA | 0.686 | 0.703 | -0.017 | 0.017 |
| 56 | ASP | 58 | LEU | 0.340 | 0.355 | -0.015 | 0.015 |
| 288 | VAL | 292 | ILE | 0.664 | 0.649 | 0.015 | 0.015 |
| 128 | VAL | 133 | GLY | 0.059 | 0.044 | 0.014 | 0.014 |
| 334 | ASN | 335 | PRO | 0.914 | 0.901 | 0.013 | 0.013 |
| 298 | ILE | 324 | ILE | 1.486 | 1.474 | 0.012 | 0.012 |
| 32 | VAL | 129 | ASN | 0.225 | 0.237 | -0.012 | 0.012 |
| 300 | ILE | 304 | ILE | 1.021 | 1.009 | 0.012 | 0.012 |
| 280 | ILE | 284 | VAL | 0.130 | 0.119 | 0.011 | 0.011 |
| 31 | TRP | 324 | ILE | 0.734 | 0.724 | 0.010 | 0.010 |
| 209 | THR | 218 | ASP | 0.951 | 0.960 | -0.009 | 0.009 |
| 17 | LEU | 18 | ALA | 0.000 | 0.008 | -0.008 | 0.008 |
| 135 | TRP | 136 | PRO | 0.298 | 0.291 | 0.008 | 0.008 |
| 173 | HIS | 174 | PRO | 0.103 | 0.096 | 0.007 | 0.007 |
| 119 | ALA | 149 | ASP | 0.006 | 0.000 | 0.006 | 0.006 |
| 37 | LEU | 312 | GLU | 0.000 | 0.006 | -0.006 | 0.006 |
| 93 | TYR | 94 | VAL | 0.165 | 0.159 | 0.006 | 0.006 |
| 142 | CYS | 210 | THR | 0.898 | 0.893 | 0.005 | 0.005 |
| 248 | LEU | 253 | CYS | 0.003 | 0.000 | 0.003 | 0.003 |
| 246 | PRO | 251 | THR | 0.003 | 0.000 | 0.003 | 0.003 |
| 66 | SER | 68 | ILE | 0.338 | 0.335 | 0.003 | 0.003 |
| 154 | PHE | 197 | SER | 2.359 | 2.357 | 0.002 | 0.002 |
| 240 | ILE | 246 | PRO | 0.501 | 0.499 | 0.002 | 0.002 |
| 124 | PRO | 127 | SER | 0.000 | 0.002 | -0.002 | 0.002 |
| 27 | SER | 213 | ARG | 0.002 | 0.000 | 0.002 | 0.002 |
| 168 | TYR | 169 | ILE | 0.295 | 0.297 | -0.001 | 0.001 |
| 128 | VAL | 136 | PRO | 0.115 | 0.116 | -0.001 | 0.001 |
| 141 | LEU | 144 | ILE | 0.090 | 0.088 | 0.001 | 0.001 |
| 126 | GLN | 135 | TRP | 0.000 | 0.001 | -0.001 | 0.001 |
| 250 | ILE | 254 | TYR | 1.069 | 1.068 | 0.001 | 0.001 |
| 162 | THR | 163 | MET | 0.000 | 0.001 | -0.001 | 0.001 |
RRCS change distribution
-0.03
Mean ΔRRCS
1.81
Std Dev
-0.02
Median
Magnitude classification
22
High (|Δ| ≥ 5.0)
72
Medium (2.5 ≤ |Δ| < 5.0)
725
Low (|Δ| < 2.5)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.52, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar