OPSD
928
Total Contact Pairs
119
Significant Changes
9.14
Max Increase
-13.67
Max Decrease
Interactive snake plot
GPCRdb-style topology. Click the view buttons to recolor residues by different data layers. Toggle contact links to draw significant residue-residue contacts as arcs. Click loop labels (ICL/ECL) to expand or collapse loop regions.
Color convention: blue = active-favoring, red = inactive-favoring.
Top 100 conformational changes
Residue pairs with the largest RRCS changes between active and inactive states. GPCRdb numbering in parentheses. Highlighted rows exceed the significance threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | TYR306 (7.53x53) | PHE313 (8.50x50) | 0.000 | 13.672 | -13.672 | HIGH |
| 2 | TYR268 (6.51x51) | PRO291 (7.38x37) | 11.720 | 2.578 | +9.143 | HIGH |
| 3 | GLU134 (3.49x49) | ARG135 (3.50x50) | 0.000 | 8.266 | -8.266 | HIGH |
| 4 | LEU76 (2.43x43) | TYR306 (7.53x53) | 1.558 | 9.658 | -8.100 | HIGH |
| 5 | TYR306 (7.53x53) | ASN310 (8.47x47) | 0.000 | 8.065 | -8.065 | HIGH |
| 6 | THR97 (2.64x63) | PHE103 (23.50x50) | 1.369 | 8.518 | -7.149 | HIGH |
| 7 | GLU249 (6.32x32) | ARG252 (6.35x35) | 8.225 | 1.103 | +7.122 | HIGH |
| 8 | LEU68 (12.50x50) | ASN73 (2.40x40) | 4.605 | 11.604 | -6.998 | HIGH |
| 9 | MET257 (6.40x40) | TYR306 (7.53x53) | 6.964 | 0.000 | +6.964 | HIGH |
| 10 | ARG135 (3.50x50) | VAL250 (6.33x33) | 0.000 | 6.100 | -6.100 | HIGH |
| 11 | LEU131 (3.46x46) | ARG135 (3.50x50) | 6.215 | 0.281 | +5.934 | HIGH |
| 12 | LEU128 (3.43x43) | TYR306 (7.53x53) | 5.817 | 0.000 | +5.817 | HIGH |
| 13 | LEU40 (1.35x35) | PHE293 (7.40x39) | 0.000 | 5.727 | -5.727 | HIGH |
| 14 | LYS311 (8.48x48) | GLU332 | 5.464 | 0.000 | +5.464 | HIGH |
| 15 | GLU239 | GLN244 (6.27x27) | 0.000 | 5.373 | -5.373 | HIGH |
| 16 | LYS231 (5.66x66) | GLU247 (6.30x30) | 5.279 | 0.000 | +5.279 | HIGH |
| 17 | PHE261 (6.44x44) | TRP265 (6.48x48) | 2.171 | 7.262 | -5.091 | HIGH |
| 18 | VAL204 (5.39x40) | PHE276 (6.59x59) | 0.186 | 5.256 | -5.070 | HIGH |
| 19 | THR94 (2.61x60) | GLU113 (3.28x28) | 0.477 | 5.499 | -5.022 | HIGH |
| 20 | GLU122 (3.37x37) | HIS211 (5.46x461) | 3.616 | 8.589 | -4.973 | MED |
| 21 | GLY89 (2.56x551) | PHE116 (3.31x31) | 0.267 | 4.985 | -4.718 | MED |
| 22 | LEU47 (1.42x42) | PHE91 (2.58x57) | 5.779 | 1.179 | +4.600 | MED |
| 23 | PHE208 (5.43x44) | PHE273 (6.56x56) | 1.231 | 5.768 | -4.537 | MED |
| 24 | GLU5 | THR193 | 0.000 | 4.523 | -4.523 | MED |
| 25 | TYR136 (3.51x51) | PRO142 (34.50x50) | 5.207 | 0.698 | +4.510 | MED |
| 26 | THR97 (2.64x63) | CYS185 | 7.063 | 2.575 | +4.488 | MED |
| 27 | TYR268 (6.51x51) | ALA292 (7.39x38) | 6.323 | 1.955 | +4.367 | MED |
| 28 | GLU181 | GLY188 (45.51x51) | 0.865 | 5.222 | -4.357 | MED |
| 29 | LEU68 (12.50x50) | GLN312 (8.49x49) | 5.907 | 1.609 | +4.298 | MED |
| 30 | THR62 (1.57x57) | ARG69 (12.51x51) | 4.751 | 0.502 | +4.249 | MED |
| 31 | ALA82 (2.49x49) | GLY120 (3.35x35) | 4.494 | 0.297 | +4.197 | MED |
| 32 | ARG69 (12.51x51) | TYR74 (2.41x41) | 0.074 | 4.170 | -4.095 | MED |
| 33 | TYR43 (1.38x38) | PHE293 (7.40x39) | 9.726 | 5.680 | +4.046 | MED |
| 34 | VAL304 (7.51x51) | MET309 (7.56x56) | 4.032 | 0.000 | +4.032 | MED |
| 35 | GLU181 | MET288 (7.35x34) | 0.000 | 3.989 | -3.989 | MED |
| 36 | LEU125 (3.40x40) | TRP265 (6.48x48) | 3.977 | 0.000 | +3.977 | MED |
| 37 | TYR191 | ALA272 (6.55x55) | 2.198 | 6.153 | -3.954 | MED |
| 38 | LEU125 (3.40x40) | PHE261 (6.44x44) | 1.306 | 5.256 | -3.950 | MED |
| 39 | TYR192 | GLN279 | 0.000 | 3.924 | -3.924 | MED |
| 40 | LEU131 (3.46x46) | VAL254 (6.37x37) | 0.000 | 3.896 | -3.896 | MED |
| 41 | GLU249 (6.32x32) | LYS311 (8.48x48) | 0.000 | 3.873 | -3.873 | MED |
| 42 | SER343 | GLN344 | 3.747 | 0.000 | +3.747 | MED |
| 43 | TYR191 | GLN279 | 0.000 | 3.675 | -3.675 | MED |
| 44 | LEU72 (2.39x39) | PHE148 (34.56x56) | 3.666 | 0.000 | +3.666 | MED |
| 45 | TYR10 | TYR192 | 1.627 | 5.246 | -3.619 | MED |
| 46 | GLN237 (5.72x72) | THR243 (6.26x26) | 3.607 | 0.000 | +3.607 | MED |
| 47 | ASN315 (8.52x52) | ASN326 | 0.000 | 3.600 | -3.600 | MED |
| 48 | ASN2 | SER281 | 0.233 | 3.807 | -3.573 | MED |
| 49 | PHE212 (5.47x47) | ALA269 (6.52x52) | 4.351 | 0.832 | +3.519 | MED |
| 50 | LYS66 (12.48x48) | ARG69 (12.51x51) | 3.490 | 0.000 | +3.490 | MED |
| 51 | THR58 (1.53x53) | ILE307 (7.54x54) | 3.640 | 0.154 | +3.486 | MED |
| 52 | LEU68 (12.50x50) | PHE313 (8.50x50) | 4.687 | 1.218 | +3.469 | MED |
| 53 | ALA233 (5.68x68) | GLN244 (6.27x27) | 0.000 | 3.467 | -3.467 | MED |
| 54 | VAL271 (6.54x54) | PHE287 (7.34x33) | 1.806 | 5.263 | -3.457 | MED |
| 55 | TYR274 (6.57x57) | PHE283 | 3.393 | 0.000 | +3.393 | MED |
| 56 | TYR136 (3.51x51) | CYS222 (5.57x57) | 4.201 | 0.819 | +3.381 | MED |
| 57 | ALA234 (5.69x69) | GLN244 (6.27x27) | 4.259 | 0.913 | +3.346 | MED |
| 58 | TYR191 | TYR192 | 3.643 | 0.299 | +3.344 | MED |
| 59 | PHE85 (2.52x52) | PHE116 (3.31x31) | 2.761 | 6.060 | -3.300 | MED |
| 60 | ARG135 (3.50x50) | TYR223 (5.58x58) | 3.354 | 0.057 | +3.297 | MED |
| 61 | VAL230 (5.65x65) | GLU247 (6.30x30) | 3.261 | 0.000 | +3.261 | MED |
| 62 | ARG177 | LYS195 | 8.307 | 5.138 | +3.169 | MED |
| 63 | MET253 (6.36x36) | MET309 (7.56x56) | 2.184 | 5.334 | -3.150 | MED |
| 64 | MET253 (6.36x36) | TYR306 (7.53x53) | 0.000 | 3.100 | -3.100 | MED |
| 65 | GLU134 (3.49x49) | PHE148 (34.56x56) | 5.086 | 1.992 | +3.094 | MED |
| 66 | GLU113 (3.28x28) | LYS296 (7.43x42) | 0.013 | 3.097 | -3.084 | MED |
| 67 | ILE75 (2.42x42) | SER127 (3.42x42) | 5.475 | 2.398 | +3.076 | MED |
| 68 | ILE307 (7.54x54) | PHE313 (8.50x50) | 4.503 | 1.435 | +3.068 | MED |
| 69 | TYR191 | PHE276 (6.59x59) | 0.000 | 3.047 | -3.047 | MED |
| 70 | TRP175 | PHE203 (5.38x39) | 12.439 | 9.401 | +3.038 | MED |
| 71 | SER93 (2.60x59) | GLY109 (3.24x24) | 0.000 | 3.014 | -3.014 | MED |
| 72 | ASN73 (2.40x40) | PHE313 (8.50x50) | 3.151 | 0.138 | +3.013 | MED |
| 73 | LEU183 | THR289 | 1.151 | 4.132 | -2.981 | MED |
| 74 | ILE219 | PHE261 (6.44x44) | 2.971 | 0.000 | +2.971 | MED |
| 75 | PRO71 | PHE148 (34.56x56) | 1.672 | 4.624 | -2.951 | MED |
| 76 | LEU194 | GLU201 | 0.000 | 2.948 | -2.948 | MED |
| 77 | ILE189 | TYR191 | 0.116 | 3.061 | -2.945 | MED |
| 78 | PRO303 | MET308 | 2.933 | 0.000 | +2.933 | MED |
| 79 | ASN73 (2.40x40) | TYR306 (7.53x53) | 0.000 | 2.903 | -2.903 | MED |
| 80 | TYR96 | HIS100 | 5.762 | 8.657 | -2.894 | MED |
| 81 | CYS264 | TRP265 (6.48x48) | 5.867 | 2.977 | +2.889 | MED |
| 82 | PRO12 | PHE283 | 1.085 | 3.972 | -2.887 | MED |
| 83 | TYR223 (5.58x58) | MET257 (6.40x40) | 2.861 | 0.000 | +2.861 | MED |
| 84 | ILE275 | PHE283 | 4.856 | 2.023 | +2.832 | MED |
| 85 | MET308 | ARG314 | 3.624 | 0.792 | +2.832 | MED |
| 86 | GLU181 | TYR268 (6.51x51) | 2.160 | 4.964 | -2.804 | MED |
| 87 | PHE13 | TYR30 | 4.433 | 1.639 | +2.793 | MED |
| 88 | ARG69 (12.51x51) | GLU150 | 0.000 | 2.742 | -2.742 | MED |
| 89 | LYS67 | GLU332 | 0.000 | 2.732 | -2.732 | MED |
| 90 | SER176 | VAL198 | 6.725 | 4.007 | +2.718 | MED |
| 91 | PHE293 (7.40x39) | PHE294 | 2.704 | 0.000 | +2.704 | MED |
| 92 | ASN2 | GLY280 | 0.518 | 3.211 | -2.694 | MED |
| 93 | PRO267 | PHE294 | 2.690 | 0.000 | +2.690 | MED |
| 94 | TYR191 | MET207 | 0.000 | 2.670 | -2.670 | MED |
| 95 | ALA260 | TYR301 | 2.113 | 4.780 | -2.666 | MED |
| 96 | PRO71 | GLU150 | 2.634 | 0.000 | +2.634 | MED |
| 97 | LYS67 | GLN312 (8.49x49) | 4.286 | 1.651 | +2.634 | MED |
| 98 | PHE103 (23.50x50) | SER186 | 1.290 | 3.920 | -2.630 | MED |
| 99 | PHE203 (5.38x39) | MET207 | 2.864 | 0.276 | +2.588 | MED |
| 100 | GLN238 | GLN244 (6.27x27) | 2.562 | 0.000 | +2.562 | MED |
Transmembrane domain analysis
Active-favoring residues form stronger contacts in the active state (positive ΔRRCS). Inactive-favoring residues form stronger contacts in the inactive state (negative ΔRRCS). Only residues with |ΔRRCS| ≥ 2.35 are shown (per-receptor significance threshold = max(mean(|Δ|) + σ, 0.2)).
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 40-62 | 47 (4.6), 62 (4.2), 43 (4.0), 58 (3.5) | 4 | 40 (-5.7) | 1 |
| TM2 | 72-97 | 91 (4.6), 82 (4.2), 72 (3.7), 75 (3.1) | 4 | 76 (-8.1), 97 (-7.1), 73 (-7.0), 94 (-5.0), 89 (-4.7), 74 (-4.1), 85 (-3.3), 93 (-3.0) | 8 |
| TM3 | 109-136 | 131 (5.9), 128 (5.8), 136 (4.5), 120 (4.2), 125 (4.0), 127 (3.1) | 6 | 134 (-8.3), 135 (-8.3), 113 (-5.0), 122 (-5.0), 116 (-4.7), 109 (-3.0) | 6 |
| TM4 | - | - | 0 | - | 0 |
| TM5 | 203-237 | 231 (5.3), 237 (3.6), 212 (3.5), 222 (3.4), 234 (3.3), 223 (3.3), 230 (3.3), 203 (3.0) | 8 | 204 (-5.1), 211 (-5.0), 208 (-4.5), 233 (-3.5) | 4 |
| TM6 | 243-276 | 268 (9.1), 249 (7.1), 252 (7.1), 257 (7.0), 247 (5.3), 243 (3.6), 269 (3.5), 274 (3.4) | 8 | 250 (-6.1), 244 (-5.4), 261 (-5.1), 265 (-5.1), 276 (-5.1), 273 (-4.5), 272 (-4.0), 254 (-3.9), 271 (-3.5), 253 (-3.2) | 10 |
| TM7 | 287-309 | 291 (9.1), 292 (4.4), 304 (4.0), 309 (4.0), 307 (3.5) | 5 | 306 (-13.7), 293 (-5.7), 288 (-4.0), 287 (-3.5), 296 (-3.1) | 5 |
| Intracellular / Extracellular loops & H8 | |||||
| ICL1 | 66-69 | 69 (4.2), 66 (3.5) | 2 | 68 (-7.0) | 1 |
| ICL2 | 142-148 | 142 (4.5), 148 (3.7) | 2 | - | 0 |
| ICL3 | 239-239 | - | 0 | 239 (-5.4) | 1 |
| ECL1 | 103-103 | - | 0 | 103 (-7.1) | 1 |
| ECL2 | 175-195 | 185 (4.5), 177 (3.2), 195 (3.2), 175 (3.0) | 4 | 193 (-4.5), 181 (-4.4), 188 (-4.4), 191 (-4.0), 192 (-3.9) | 5 |
| ECL3 | 279-283 | 283 (3.4) | 1 | 279 (-3.9), 281 (-3.6) | 2 |
| H8 | 310-315 | 311 (5.5), 312 (4.3) | 2 | 313 (-13.7), 310 (-8.1), 315 (-3.6) | 3 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Variants of interest
104 variants mapped to contact positions, sorted by |ΔRRCS| impact.
| Position | Protein change | DNA change | Allele freq | Het / Hom | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 306 | p.Tyr306Cys | c.917A>G | 2.05e-06 | 3 / 0 | 13.67 | 0.976 | PATHOGENIC | 0.99 | |
| 306 | p.Tyr306Phe | c.917A>T | 6.84e-07 | 1 / 0 | 13.67 | - | nan | - | |
| 134 | p.Glu134Lys | c.400G>A | 4.79e-06 | 7 / 0 | 8.27 | 0.994 | PATHOGENIC | 0.95 | rs766196737 |
| 135 | p.Arg135Trp | c.403C>T | 1.37e-06 | 2 / 0 | 8.27 | 0.994 | PATHOGENIC | 0.96 | rs104893775 |
| 135 | p.Arg135Gln | c.404G>A | 6.16e-06 | 9 / 0 | 8.27 | - | nan | - | rs104893774 |
| 103 | p.Phe103Leu | c.307T>C | 6.84e-07 | 1 / 0 | 7.15 | 0.996 | PATHOGENIC | 0.89 | |
| 97 | p.Thr97Asn | c.290C>A | 6.57e-06 | 1 / 0 | 7.15 | 0.711 | PATHOGENIC | 0.54 | rs1341056779 |
| 97 | p.Thr97Ile | c.290C>T | 6.57e-06 | 1 / 0 | 7.15 | - | nan | - | rs1341056779 |
| 103 | p.Phe103Tyr | c.308T>A | 2.05e-06 | 3 / 0 | 7.15 | - | nan | - | |
| 249 | p.Glu249Lys | c.745G>A | 1.37e-06 | 2 / 0 | 7.12 | 0.927 | PATHOGENIC | 0.96 | rs104893783 |
| 252 | p.Arg252Cys | c.754C>T | 5.47e-06 | 8 / 0 | 7.12 | 0.631 | PATHOGENIC | 0.92 | rs752805805 |
| 252 | p.Arg252Leu | c.755G>T | 2.05e-06 | 3 / 0 | 7.12 | - | nan | - | |
| 252 | p.Arg252His | c.755G>A | 1.50e-05 | 22 / 0 | 7.12 | - | nan | - | rs765438313 |
| 252 | p.Arg252Pro | c.755G>C | 8.96e-05 | 131 / 0 | 7.12 | - | nan | - | rs765438313 |
| 73 | p.Asn73Lys | c.219C>A | 6.91e-05 | 101 / 0 | 7.00 | 0.996 | PATHOGENIC | 0.97 | rs374902462 |
| 68 | p.Leu68Arg | c.203T>G | 9.44e-05 | 138 / 0 | 7.00 | 0.984 | PATHOGENIC | 0.96 | rs137883686 |
| 68 | p.Leu68Pro | c.203T>C | 6.84e-07 | 1 / 0 | 7.00 | - | nan | - | |
| 257 | p.Met257Val | c.769A>G | 6.84e-07 | 1 / 0 | 6.96 | 0.931 | PATHOGENIC | 0.97 | rs1238756481 |
| 250 | p.Val250Ala | c.749T>C | 1.57e-05 | 23 / 0 | 6.10 | 0.984 | PATHOGENIC | 0.97 | rs765519035 |
| 250 | p.Val250Gly | c.749T>G | 1.37e-05 | 20 / 0 | 6.10 | - | nan | - | rs765519035 |
| 40 | p.Leu40Val | c.118C>G | 6.84e-07 | 1 / 0 | 5.73 | 0.249 | BENIGN | 0.58 | |
| 332 | p.Glu332Lys | c.994G>A | 2.74e-06 | 2 / 1 | 5.46 | 0.398 | AMBIGUOUS | 0.74 | |
| 332 | p.Glu332Val | c.995A>T | 6.84e-07 | 1 / 0 | 5.46 | - | nan | - | rs773295145 |
| 244 | p.Gln244His | c.732G>C | 6.84e-07 | 1 / 0 | 5.37 | 0.918 | PATHOGENIC | 0.98 | rs148222991 |
| 261 | p.Phe261Leu | c.783C>A | 1.16e-05 | 17 / 0 | 5.09 | 0.999 | PATHOGENIC | 0.95 | rs199583468 |
| 276 | p.Phe276Val | c.826T>G | 2.74e-05 | 40 / 0 | 5.07 | 0.887 | PATHOGENIC | 0.61 | rs766943400 |
| 204 | p.Val204Leu | c.610G>C | 6.84e-07 | 1 / 0 | 5.07 | 0.806 | PATHOGENIC | 0.81 | |
| 122 | p.Glu122Lys | c.364G>A | 6.57e-06 | 1 / 0 | 4.97 | 0.886 | PATHOGENIC | 0.47 | rs774865494 |
| 122 | p.Glu122Gly | c.365A>G | 1.37e-06 | 2 / 0 | 4.97 | - | nan | - | rs762059468 |
| 116 | p.Phe116Tyr | c.347T>A | 3.42e-06 | 5 / 0 | 4.72 | 0.606 | PATHOGENIC | 0.55 | rs148801522 |
| 89 | p.Gly89Ala | c.266G>C | 6.57e-06 | 1 / 0 | 4.72 | 0.194 | BENIGN | 0.45 | rs104893772 |
| 208 | p.Phe208Leu | c.624C>G | 1.37e-06 | 2 / 0 | 4.54 | 0.980 | PATHOGENIC | 0.92 | rs113751838 |
| 193 | p.Thr193Lys | c.578C>A | 1.37e-06 | 2 / 0 | 4.52 | 0.848 | PATHOGENIC | 0.96 | rs373974298 |
| 5 | p.Glu5Gly | c.14A>G | 3.42e-06 | 5 / 0 | 4.52 | 0.368 | AMBIGUOUS | 0.93 | rs144270441 |
| 193 | p.Thr193Met | c.578C>T | 2.26e-05 | 33 / 0 | 4.52 | - | nan | - | rs373974298 |
| 142 | p.Pro142Leu | c.425C>T | 6.84e-07 | 1 / 0 | 4.51 | 0.979 | PATHOGENIC | 0.98 | |
| 185 | p.Cys185Arg | c.553T>C | 2.74e-06 | 4 / 0 | 4.49 | 0.980 | PATHOGENIC | 0.80 | rs1236550448 |
| 185 | p.Cys185Phe | c.554G>T | 6.84e-07 | 1 / 0 | 4.49 | - | nan | - | |
| 292 | p.Ala292Thr | c.874G>A | 6.84e-07 | 1 / 0 | 4.37 | 0.742 | PATHOGENIC | 0.74 | rs2084792892 |
| 188 | p.Gly188Glu | c.563G>A | 2.05e-06 | 3 / 0 | 4.36 | 0.993 | PATHOGENIC | 0.95 | rs1424131846 |
| 181 | p.Glu181Gln | c.541G>C | 4.10e-06 | 6 / 0 | 4.36 | 0.930 | PATHOGENIC | 0.99 | rs775557680 |
| 69 | p.Arg69Cys | c.205C>T | 3.76e-05 | 55 / 0 | 4.25 | 0.852 | PATHOGENIC | 0.93 | rs761101263 |
| 62 | p.Thr62Ala | c.184A>G | 6.84e-07 | 1 / 0 | 4.25 | 0.714 | PATHOGENIC | 0.89 | rs759425622 |
| 62 | p.Thr62Asn | c.185C>A | 2.12e-05 | 31 / 0 | 4.25 | - | nan | - | rs769464362 |
| 69 | p.Arg69His | c.206G>A | 2.12e-05 | 31 / 0 | 4.25 | - | nan | - | rs118173887 |
| 69 | p.Arg69Leu | c.206G>T | 6.84e-07 | 1 / 0 | 4.25 | - | nan | - | |
| 120 | p.Gly120Ser | c.358G>A | 1.37e-06 | 2 / 0 | 4.20 | 0.833 | PATHOGENIC | 0.77 | |
| 120 | p.Gly120Cys | c.358G>T | 6.85e-07 | 1 / 0 | 4.20 | - | nan | - | rs1356947962 |
| 120 | p.Gly120Ala | c.359G>C | 4.11e-06 | 6 / 0 | 4.20 | - | nan | - | rs768251138 |
| 120 | p.Gly120Asp | c.359G>A | 2.06e-06 | 3 / 0 | 4.20 | - | nan | - | rs768251138 |
| 74 | p.Tyr74His | c.220T>C | 4.79e-06 | 7 / 0 | 4.10 | 0.893 | PATHOGENIC | 0.92 | rs758491851 |
| 74 | p.Tyr74Cys | c.221A>G | 6.84e-07 | 1 / 0 | 4.10 | - | nan | - | |
| 43 | p.Tyr43Cys | c.128A>G | 3.35e-05 | 49 / 0 | 4.05 | 0.613 | PATHOGENIC | 0.75 | rs748429090 |
| 304 | p.Val304Ala | c.911T>C | 6.84e-07 | 1 / 0 | 4.03 | 0.589 | PATHOGENIC | 0.70 | |
| 309 | p.Met309Leu | c.925A>T | 2.74e-06 | 4 / 0 | 4.03 | 0.276 | BENIGN | 0.75 | rs146391463 |
| 309 | p.Met309Thr | c.926T>C | 6.84e-07 | 1 / 0 | 4.03 | - | nan | - | rs759818475 |
| 309 | p.Met309Lys | c.926T>A | 6.84e-07 | 1 / 0 | 4.03 | - | nan | - | rs759818475 |
| 288 | p.Met288Arg | c.863T>G | 6.84e-07 | 1 / 0 | 3.99 | 0.910 | PATHOGENIC | 0.61 | |
| 288 | p.Met288Thr | c.863T>C | 6.84e-07 | 1 / 0 | 3.99 | - | nan | - | |
| 125 | p.Leu125Pro | c.374T>C | 6.84e-07 | 1 / 0 | 3.98 | 0.995 | PATHOGENIC | 0.78 | rs1399039412 |
| 272 | p.Ala272Thr | c.814G>A | 2.74e-06 | 4 / 0 | 3.95 | 0.732 | PATHOGENIC | 0.90 | rs2084789744 |
| 191 | p.Tyr191Phe | c.572A>T | 6.84e-07 | 1 / 0 | 3.95 | 0.380 | AMBIGUOUS | 0.69 | |
| 272 | p.Ala272Val | c.815C>T | 6.84e-07 | 1 / 0 | 3.95 | - | nan | - | |
| 192 | p.Tyr192Asn | c.574T>A | 6.84e-07 | 1 / 0 | 3.92 | 0.831 | PATHOGENIC | 0.96 | |
| 279 | p.Gln279Glu | c.835C>G | 6.84e-07 | 1 / 0 | 3.92 | 0.114 | BENIGN | 0.60 | |
| 279 | p.Gln279Pro | c.836A>C | 6.84e-07 | 1 / 0 | 3.92 | - | nan | - | rs2084790946 |
| 254 | p.Val254Ala | c.761T>C | 1.37e-06 | 2 / 0 | 3.90 | 0.951 | PATHOGENIC | 0.73 | |
| 343 | p.Ser343Arg | c.1029C>G | 6.84e-07 | 1 / 0 | 3.75 | 0.810 | PATHOGENIC | 0.88 | rs1486594657 |
| 344 | p.Gln344Lys | c.1030C>A | 1.37e-06 | 2 / 0 | 3.75 | 0.129 | BENIGN | 0.51 | |
| 344 | p.Gln344His | c.1032G>C | 2.74e-06 | 4 / 0 | 3.75 | - | nan | - | rs749753555 |
| 148 | p.Phe148Leu | c.444C>G | 6.84e-07 | 1 / 0 | 3.67 | 0.991 | PATHOGENIC | 0.97 | |
| 72 | p.Leu72Phe | c.214C>T | 2.05e-06 | 1 / 1 | 3.67 | 0.966 | PATHOGENIC | 0.97 | |
| 148 | p.Phe148Leu | c.444C>A | 8.21e-06 | 12 / 0 | 3.67 | - | nan | - | |
| 237 | p.Gln237Glu | c.709C>G | 6.84e-07 | 1 / 0 | 3.61 | 0.387 | AMBIGUOUS | 0.94 | |
| 237 | p.Gln237Leu | c.710A>T | 8.21e-06 | 12 / 0 | 3.61 | - | nan | - | rs774809893 |
| 237 | p.Gln237His | c.711G>T | 4.10e-06 | 6 / 0 | 3.61 | - | nan | - | rs374550929 |
| 326 | p.Asn326Ser | c.977A>G | 2.05e-06 | 3 / 0 | 3.60 | 0.173 | BENIGN | 0.36 | rs1264835715 |
| 315 | p.Asn315His | c.943A>C | 6.84e-07 | 1 / 0 | 3.60 | 0.135 | BENIGN | 0.52 | |
| 281 | p.Ser281Phe | c.842C>T | 6.84e-07 | 1 / 0 | 3.57 | 0.482 | AMBIGUOUS | 0.44 | |
| 2 | p.Asn2Asp | c.4A>G | 4.79e-06 | 7 / 0 | 3.57 | 0.212 | BENIGN | 0.76 | |
| 2 | p.Asn2Ser | c.5A>G | 6.84e-07 | 1 / 0 | 3.57 | - | nan | - | rs2084755497 |
| 269 | p.Ala269Thr | c.805G>A | 2.74e-06 | 4 / 0 | 3.52 | 0.583 | PATHOGENIC | 0.89 | rs200894277 |
| 66 | p.Lys66Gln | c.196A>C | 6.84e-07 | 1 / 0 | 3.49 | 0.441 | AMBIGUOUS | 0.96 | |
| 58 | p.Thr58Lys | c.173C>A | 6.84e-07 | 1 / 0 | 3.49 | 0.994 | PATHOGENIC | 0.79 | |
| 307 | p.Ile307Val | c.919A>G | 2.05e-06 | 3 / 0 | 3.49 | 0.150 | BENIGN | 0.65 | |
| 58 | p.Thr58Arg | c.173C>G | 6.84e-07 | 1 / 0 | 3.49 | - | nan | - | rs28933394 |
| 58 | p.Thr58Met | c.173C>T | 1.94e-04 | 283 / 0 | 3.49 | - | nan | - | rs28933394 |
| 307 | p.Ile307Phe | c.919A>T | 1.24e-04 | 175 / 3 | 3.49 | - | nan | - | rs771322615 |
| 307 | p.Ile307Met | c.921C>G | 6.84e-07 | 1 / 0 | 3.49 | - | nan | - | rs1238542520 |
| 233 | p.Ala233Val | c.698C>T | 6.84e-07 | 1 / 0 | 3.47 | 0.390 | AMBIGUOUS | 0.79 | |
| 287 | p.Phe287Leu | c.859T>C | 6.84e-07 | 1 / 0 | 3.46 | 0.606 | PATHOGENIC | 0.54 | |
| 271 | p.Val271Met | c.811G>A | 1.78e-05 | 26 / 0 | 3.46 | 0.425 | AMBIGUOUS | 0.55 | rs201008735 |
| 274 | p.Tyr274Phe | c.821A>T | 6.84e-07 | 1 / 0 | 3.39 | 0.071 | BENIGN | 0.55 | |
| 234 | p.Ala234Ser | c.700G>T | 6.57e-06 | 1 / 0 | 3.35 | 0.353 | AMBIGUOUS | 0.92 | rs547981493 |
| 234 | p.Ala234Thr | c.700G>A | 8.21e-06 | 12 / 0 | 3.35 | - | nan | - | rs547981493 |
| 230 | p.Val230Leu | c.688G>C | 6.84e-07 | 1 / 0 | 3.26 | 0.737 | PATHOGENIC | 0.72 | |
| 230 | p.Val230Ile | c.688G>A | 1.51e-05 | 22 / 0 | 3.26 | - | nan | - | rs780188527 |
| 177 | p.Arg177Lys | c.530G>A | 6.57e-06 | 1 / 0 | 3.17 | 0.469 | AMBIGUOUS | 0.90 | rs776654836 |
| 253 | p.Met253Val | c.757A>G | 6.84e-07 | 1 / 0 | 3.15 | 0.977 | PATHOGENIC | 0.97 | rs1207948458 |
| 253 | p.Met253Thr | c.758T>C | 2.05e-06 | 3 / 0 | 3.15 | - | nan | - | rs1191932068 |
| 253 | p.Met253Ile | c.759G>T | 2.94e-05 | 43 / 0 | 3.15 | - | nan | - | rs756658659 |
| 75 | p.Ile75Val | c.223A>G | 3.42e-06 | 5 / 0 | 3.08 | 0.346 | AMBIGUOUS | 0.95 | rs367633279 |
| 175 | p.Trp175Leu | c.524G>T | 2.74e-06 | 4 / 0 | 3.04 | 0.961 | PATHOGENIC | 0.98 | rs760894205 |
| 109 | p.Gly109Arg | c.325G>A | 6.57e-06 | 1 / 0 | 3.01 | 0.969 | PATHOGENIC | 0.53 | rs1415160298 |
Complete RRCS results
Top 1000 contact pairs by |ΔRRCS|. Significance threshold: |ΔRRCS| ≥ 2.35, computed as max(mean(|Δ|) + σ, 0.2). Highlighted rows indicate significant changes.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 306 | TYR | 313 | PHE | 0.000 | 13.672 | -13.672 | 13.672 |
| 268 | TYR | 291 | PRO | 11.720 | 2.578 | 9.143 | 9.143 |
| 134 | GLU | 135 | ARG | 0.000 | 8.266 | -8.266 | 8.266 |
| 76 | LEU | 306 | TYR | 1.558 | 9.658 | -8.100 | 8.100 |
| 306 | TYR | 310 | ASN | 0.000 | 8.065 | -8.065 | 8.065 |
| 97 | THR | 103 | PHE | 1.369 | 8.518 | -7.149 | 7.149 |
| 249 | GLU | 252 | ARG | 8.225 | 1.103 | 7.122 | 7.122 |
| 68 | LEU | 73 | ASN | 4.605 | 11.604 | -6.998 | 6.998 |
| 257 | MET | 306 | TYR | 6.964 | 0.000 | 6.964 | 6.964 |
| 135 | ARG | 250 | VAL | 0.000 | 6.100 | -6.100 | 6.100 |
| 131 | LEU | 135 | ARG | 6.215 | 0.281 | 5.934 | 5.934 |
| 128 | LEU | 306 | TYR | 5.817 | 0.000 | 5.817 | 5.817 |
| 40 | LEU | 293 | PHE | 0.000 | 5.727 | -5.727 | 5.727 |
| 311 | LYS | 332 | GLU | 5.464 | 0.000 | 5.464 | 5.464 |
| 239 | GLU | 244 | GLN | 0.000 | 5.373 | -5.373 | 5.373 |
| 231 | LYS | 247 | GLU | 5.279 | 0.000 | 5.279 | 5.279 |
| 261 | PHE | 265 | TRP | 2.171 | 7.262 | -5.091 | 5.091 |
| 204 | VAL | 276 | PHE | 0.186 | 5.256 | -5.070 | 5.070 |
| 94 | THR | 113 | GLU | 0.477 | 5.499 | -5.022 | 5.022 |
| 122 | GLU | 211 | HIS | 3.616 | 8.589 | -4.973 | 4.973 |
| 89 | GLY | 116 | PHE | 0.267 | 4.985 | -4.718 | 4.718 |
| 47 | LEU | 91 | PHE | 5.779 | 1.179 | 4.600 | 4.600 |
| 208 | PHE | 273 | PHE | 1.231 | 5.768 | -4.537 | 4.537 |
| 5 | GLU | 193 | THR | 0.000 | 4.523 | -4.523 | 4.523 |
| 136 | TYR | 142 | PRO | 5.207 | 0.698 | 4.510 | 4.510 |
| 97 | THR | 185 | CYS | 7.063 | 2.575 | 4.488 | 4.488 |
| 268 | TYR | 292 | ALA | 6.323 | 1.955 | 4.367 | 4.367 |
| 181 | GLU | 188 | GLY | 0.865 | 5.222 | -4.357 | 4.357 |
| 68 | LEU | 312 | GLN | 5.907 | 1.609 | 4.298 | 4.298 |
| 62 | THR | 69 | ARG | 4.751 | 0.502 | 4.249 | 4.249 |
| 82 | ALA | 120 | GLY | 4.494 | 0.297 | 4.197 | 4.197 |
| 69 | ARG | 74 | TYR | 0.074 | 4.170 | -4.095 | 4.095 |
| 43 | TYR | 293 | PHE | 9.726 | 5.680 | 4.046 | 4.046 |
| 304 | VAL | 309 | MET | 4.032 | 0.000 | 4.032 | 4.032 |
| 181 | GLU | 288 | MET | 0.000 | 3.989 | -3.989 | 3.989 |
| 125 | LEU | 265 | TRP | 3.977 | 0.000 | 3.977 | 3.977 |
| 191 | TYR | 272 | ALA | 2.198 | 6.153 | -3.954 | 3.954 |
| 125 | LEU | 261 | PHE | 1.306 | 5.256 | -3.950 | 3.950 |
| 192 | TYR | 279 | GLN | 0.000 | 3.924 | -3.924 | 3.924 |
| 131 | LEU | 254 | VAL | 0.000 | 3.896 | -3.896 | 3.896 |
| 249 | GLU | 311 | LYS | 0.000 | 3.873 | -3.873 | 3.873 |
| 343 | SER | 344 | GLN | 3.747 | 0.000 | 3.747 | 3.747 |
| 191 | TYR | 279 | GLN | 0.000 | 3.675 | -3.675 | 3.675 |
| 72 | LEU | 148 | PHE | 3.666 | 0.000 | 3.666 | 3.666 |
| 10 | TYR | 192 | TYR | 1.627 | 5.246 | -3.619 | 3.619 |
| 237 | GLN | 243 | THR | 3.607 | 0.000 | 3.607 | 3.607 |
| 315 | ASN | 326 | ASN | 0.000 | 3.600 | -3.600 | 3.600 |
| 2 | ASN | 281 | SER | 0.233 | 3.807 | -3.573 | 3.573 |
| 212 | PHE | 269 | ALA | 4.351 | 0.832 | 3.519 | 3.519 |
| 66 | LYS | 69 | ARG | 3.490 | 0.000 | 3.490 | 3.490 |
| 58 | THR | 307 | ILE | 3.640 | 0.154 | 3.486 | 3.486 |
| 68 | LEU | 313 | PHE | 4.687 | 1.218 | 3.469 | 3.469 |
| 233 | ALA | 244 | GLN | 0.000 | 3.467 | -3.467 | 3.467 |
| 271 | VAL | 287 | PHE | 1.806 | 5.263 | -3.457 | 3.457 |
| 274 | TYR | 283 | PHE | 3.393 | 0.000 | 3.393 | 3.393 |
| 136 | TYR | 222 | CYS | 4.201 | 0.819 | 3.381 | 3.381 |
| 234 | ALA | 244 | GLN | 4.259 | 0.913 | 3.346 | 3.346 |
| 191 | TYR | 192 | TYR | 3.643 | 0.299 | 3.344 | 3.344 |
| 85 | PHE | 116 | PHE | 2.761 | 6.060 | -3.300 | 3.300 |
| 135 | ARG | 223 | TYR | 3.354 | 0.057 | 3.297 | 3.297 |
| 230 | VAL | 247 | GLU | 3.261 | 0.000 | 3.261 | 3.261 |
| 177 | ARG | 195 | LYS | 8.307 | 5.138 | 3.169 | 3.169 |
| 253 | MET | 309 | MET | 2.184 | 5.334 | -3.150 | 3.150 |
| 253 | MET | 306 | TYR | 0.000 | 3.100 | -3.100 | 3.100 |
| 134 | GLU | 148 | PHE | 5.086 | 1.992 | 3.094 | 3.094 |
| 113 | GLU | 296 | LYS | 0.013 | 3.097 | -3.084 | 3.084 |
| 75 | ILE | 127 | SER | 5.475 | 2.398 | 3.076 | 3.076 |
| 307 | ILE | 313 | PHE | 4.503 | 1.435 | 3.068 | 3.068 |
| 191 | TYR | 276 | PHE | 0.000 | 3.047 | -3.047 | 3.047 |
| 175 | TRP | 203 | PHE | 12.439 | 9.401 | 3.038 | 3.038 |
| 93 | SER | 109 | GLY | 0.000 | 3.014 | -3.014 | 3.014 |
| 73 | ASN | 313 | PHE | 3.151 | 0.138 | 3.013 | 3.013 |
| 183 | LEU | 289 | THR | 1.151 | 4.132 | -2.981 | 2.981 |
| 219 | ILE | 261 | PHE | 2.971 | 0.000 | 2.971 | 2.971 |
| 71 | PRO | 148 | PHE | 1.672 | 4.624 | -2.951 | 2.951 |
| 194 | LEU | 201 | GLU | 0.000 | 2.948 | -2.948 | 2.948 |
| 189 | ILE | 191 | TYR | 0.116 | 3.061 | -2.945 | 2.945 |
| 303 | PRO | 308 | MET | 2.933 | 0.000 | 2.933 | 2.933 |
| 73 | ASN | 306 | TYR | 0.000 | 2.903 | -2.903 | 2.903 |
| 96 | TYR | 100 | HIS | 5.762 | 8.657 | -2.894 | 2.894 |
| 264 | CYS | 265 | TRP | 5.867 | 2.977 | 2.889 | 2.889 |
| 12 | PRO | 283 | PHE | 1.085 | 3.972 | -2.887 | 2.887 |
| 223 | TYR | 257 | MET | 2.861 | 0.000 | 2.861 | 2.861 |
| 275 | ILE | 283 | PHE | 4.856 | 2.023 | 2.832 | 2.832 |
| 308 | MET | 314 | ARG | 3.624 | 0.792 | 2.832 | 2.832 |
| 181 | GLU | 268 | TYR | 2.160 | 4.964 | -2.804 | 2.804 |
| 13 | PHE | 30 | TYR | 4.433 | 1.639 | 2.793 | 2.793 |
| 69 | ARG | 150 | GLU | 0.000 | 2.742 | -2.742 | 2.742 |
| 67 | LYS | 332 | GLU | 0.000 | 2.732 | -2.732 | 2.732 |
| 176 | SER | 198 | VAL | 6.725 | 4.007 | 2.718 | 2.718 |
| 293 | PHE | 294 | PHE | 2.704 | 0.000 | 2.704 | 2.704 |
| 2 | ASN | 280 | GLY | 0.518 | 3.211 | -2.694 | 2.694 |
| 267 | PRO | 294 | PHE | 2.690 | 0.000 | 2.690 | 2.690 |
| 191 | TYR | 207 | MET | 0.000 | 2.670 | -2.670 | 2.670 |
| 260 | ALA | 301 | TYR | 2.113 | 4.780 | -2.666 | 2.666 |
| 71 | PRO | 150 | GLU | 2.634 | 0.000 | 2.634 | 2.634 |
| 67 | LYS | 312 | GLN | 4.286 | 1.651 | 2.634 | 2.634 |
| 103 | PHE | 186 | SER | 1.290 | 3.920 | -2.630 | 2.630 |
| 203 | PHE | 207 | MET | 2.864 | 0.276 | 2.588 | 2.588 |
| 238 | GLN | 244 | GLN | 2.562 | 0.000 | 2.562 | 2.562 |
| 60 | TYR | 64 | GLN | 2.841 | 0.282 | 2.560 | 2.560 |
| 261 | PHE | 301 | TYR | 0.000 | 2.532 | -2.532 | 2.532 |
| 252 | ARG | 309 | MET | 0.873 | 3.399 | -2.526 | 2.526 |
| 9 | PHE | 179 | ILE | 1.028 | 3.547 | -2.519 | 2.519 |
| 294 | PHE | 301 | TYR | 2.509 | 0.000 | 2.509 | 2.509 |
| 89 | GLY | 113 | GLU | 2.506 | 0.000 | 2.506 | 2.506 |
| 10 | TYR | 283 | PHE | 0.000 | 2.504 | -2.504 | 2.504 |
| 2 | ASN | 282 | ASN | 7.706 | 5.222 | 2.484 | 2.484 |
| 179 | ILE | 192 | TYR | 3.331 | 0.883 | 2.449 | 2.449 |
| 136 | TYR | 221 | PHE | 2.441 | 0.000 | 2.441 | 2.441 |
| 307 | ILE | 314 | ARG | 0.426 | 2.859 | -2.433 | 2.433 |
| 122 | GLU | 167 | CYS | 4.533 | 2.100 | 2.433 | 2.433 |
| 87 | VAL | 92 | THR | 4.456 | 2.023 | 2.432 | 2.432 |
| 128 | LEU | 261 | PHE | 0.009 | 2.410 | -2.401 | 2.401 |
| 72 | LEU | 306 | TYR | 0.000 | 2.391 | -2.391 | 2.391 |
| 191 | TYR | 288 | MET | 2.805 | 0.429 | 2.376 | 2.376 |
| 240 | SER | 243 | THR | 3.438 | 1.068 | 2.370 | 2.370 |
| 177 | ARG | 179 | ILE | 3.186 | 0.818 | 2.368 | 2.368 |
| 135 | ARG | 257 | MET | 2.352 | 0.000 | 2.352 | 2.352 |
| 135 | ARG | 247 | GLU | 0.000 | 2.345 | -2.345 | 2.345 |
| 271 | VAL | 288 | MET | 0.236 | 2.577 | -2.342 | 2.342 |
| 76 | LEU | 307 | ILE | 2.299 | 0.000 | 2.299 | 2.299 |
| 195 | LYS | 200 | ASN | 5.080 | 2.825 | 2.255 | 2.255 |
| 44 | MET | 293 | PHE | 0.000 | 2.250 | -2.250 | 2.250 |
| 75 | ILE | 131 | LEU | 2.248 | 0.000 | 2.248 | 2.248 |
| 220 | PHE | 258 | VAL | 2.242 | 0.000 | 2.242 | 2.242 |
| 207 | MET | 211 | HIS | 2.573 | 0.337 | 2.236 | 2.236 |
| 192 | TYR | 283 | PHE | 0.000 | 2.235 | -2.235 | 2.235 |
| 283 | PHE | 287 | PHE | 3.366 | 1.164 | 2.202 | 2.202 |
| 93 | SER | 105 | PHE | 2.179 | 0.000 | 2.179 | 2.179 |
| 71 | PRO | 149 | GLY | 2.177 | 0.010 | 2.167 | 2.167 |
| 305 | ILE | 306 | TYR | 2.154 | 0.000 | 2.154 | 2.154 |
| 43 | TYR | 47 | LEU | 3.239 | 5.393 | -2.154 | 2.154 |
| 176 | SER | 190 | ASP | 3.159 | 1.013 | 2.146 | 2.146 |
| 319 | THR | 326 | ASN | 0.075 | 2.217 | -2.142 | 2.142 |
| 103 | PHE | 105 | PHE | 2.130 | 0.000 | 2.130 | 2.130 |
| 86 | MET | 116 | PHE | 0.000 | 2.121 | -2.121 | 2.121 |
| 268 | TYR | 288 | MET | 0.000 | 2.110 | -2.110 | 2.110 |
| 90 | GLY | 116 | PHE | 0.000 | 2.089 | -2.089 | 2.089 |
| 135 | ARG | 226 | LEU | 1.461 | 3.543 | -2.082 | 2.082 |
| 256 | ILE | 309 | MET | 0.403 | 2.476 | -2.073 | 2.073 |
| 86 | MET | 121 | GLY | 2.295 | 0.264 | 2.031 | 2.031 |
| 337 | VAL | 341 | GLU | 0.000 | 2.024 | -2.024 | 2.024 |
| 191 | TYR | 275 | ILE | 0.636 | 2.652 | -2.016 | 2.016 |
| 58 | THR | 313 | PHE | 1.152 | 3.152 | -2.001 | 2.001 |
| 183 | LEU | 285 | PRO | 1.602 | 3.577 | -1.975 | 1.975 |
| 227 | VAL | 254 | VAL | 1.970 | 0.000 | 1.970 | 1.970 |
| 58 | THR | 317 | MET | 2.745 | 0.795 | 1.950 | 1.950 |
| 63 | VAL | 69 | ARG | 3.529 | 1.579 | 1.950 | 1.950 |
| 147 | ARG | 342 | THR | 0.000 | 1.934 | -1.934 | 1.934 |
| 75 | ILE | 134 | GLU | 1.888 | 0.000 | 1.888 | 1.888 |
| 234 | ALA | 243 | THR | 1.879 | 0.000 | 1.879 | 1.879 |
| 274 | TYR | 278 | HIS | 7.238 | 5.379 | 1.860 | 1.860 |
| 94 | THR | 186 | SER | 1.851 | 0.000 | 1.851 | 1.851 |
| 103 | PHE | 180 | PRO | 0.148 | 1.997 | -1.849 | 1.849 |
| 83 | ASP | 302 | ASN | 0.320 | 2.144 | -1.824 | 1.824 |
| 274 | TYR | 287 | PHE | 0.000 | 1.821 | -1.821 | 1.821 |
| 82 | ALA | 124 | ALA | 1.819 | 0.000 | 1.819 | 1.819 |
| 62 | THR | 77 | LEU | 3.089 | 1.279 | 1.810 | 1.810 |
| 307 | ILE | 317 | MET | 1.014 | 2.814 | -1.800 | 1.800 |
| 181 | GLU | 192 | TYR | 1.686 | 3.477 | -1.792 | 1.792 |
| 8 | ASN | 177 | ARG | 1.079 | 2.843 | -1.764 | 1.764 |
| 247 | GLU | 251 | THR | 1.763 | 0.000 | 1.763 | 1.763 |
| 22 | SER | 25 | GLU | 1.819 | 3.582 | -1.763 | 1.763 |
| 125 | LEU | 215 | PRO | 0.685 | 2.444 | -1.759 | 1.759 |
| 212 | PHE | 265 | TRP | 1.759 | 0.000 | 1.759 | 1.759 |
| 216 | MET | 261 | PHE | 2.571 | 0.832 | 1.740 | 1.740 |
| 313 | PHE | 317 | MET | 0.000 | 1.728 | -1.728 | 1.728 |
| 130 | VAL | 134 | GLU | 1.722 | 0.000 | 1.722 | 1.722 |
| 25 | GLU | 26 | TYR | 1.510 | 3.231 | -1.722 | 1.722 |
| 10 | TYR | 193 | THR | 2.485 | 0.765 | 1.720 | 1.720 |
| 227 | VAL | 231 | LYS | 1.718 | 0.000 | 1.718 | 1.718 |
| 237 | GLN | 244 | GLN | 1.715 | 0.000 | 1.715 | 1.715 |
| 30 | TYR | 31 | LEU | 1.578 | 3.282 | -1.704 | 1.704 |
| 131 | LEU | 306 | TYR | 1.698 | 0.000 | 1.698 | 1.698 |
| 264 | CYS | 295 | ALA | 2.959 | 4.656 | -1.696 | 1.696 |
| 104 | VAL | 105 | PHE | 1.682 | 0.000 | 1.682 | 1.682 |
| 29 | TYR | 37 | PHE | 3.215 | 4.869 | -1.654 | 1.654 |
| 44 | MET | 91 | PHE | 2.681 | 4.324 | -1.643 | 1.643 |
| 94 | THR | 185 | CYS | 1.403 | 3.046 | -1.643 | 1.643 |
| 340 | THR | 341 | GLU | 1.641 | 0.000 | 1.641 | 1.641 |
| 272 | ALA | 288 | MET | 0.000 | 1.641 | -1.641 | 1.641 |
| 71 | PRO | 153 | ALA | 2.874 | 1.235 | 1.640 | 1.640 |
| 37 | PHE | 101 | GLY | 4.425 | 2.787 | 1.638 | 1.638 |
| 136 | TYR | 226 | LEU | 0.105 | 1.739 | -1.634 | 1.634 |
| 79 | LEU | 83 | ASP | 1.642 | 0.013 | 1.629 | 1.629 |
| 61 | VAL | 313 | PHE | 0.302 | 1.931 | -1.629 | 1.629 |
| 177 | ARG | 190 | ASP | 9.832 | 8.207 | 1.625 | 1.625 |
| 180 | PRO | 192 | TYR | 1.602 | 0.000 | 1.602 | 1.602 |
| 174 | GLY | 198 | VAL | 4.696 | 3.099 | 1.597 | 1.597 |
| 193 | THR | 279 | GLN | 0.000 | 1.594 | -1.594 | 1.594 |
| 78 | ASN | 127 | SER | 2.758 | 1.180 | 1.579 | 1.579 |
| 86 | MET | 91 | PHE | 8.578 | 7.000 | 1.578 | 1.578 |
| 298 | ALA | 302 | ASN | 1.634 | 0.061 | 1.572 | 1.572 |
| 2 | ASN | 13 | PHE | 4.198 | 2.646 | 1.553 | 1.553 |
| 12 | PRO | 284 | GLY | 0.259 | 1.810 | -1.551 | 1.551 |
| 205 | ILE | 276 | PHE | 2.175 | 0.626 | 1.548 | 1.548 |
| 223 | TYR | 226 | LEU | 0.295 | 1.832 | -1.538 | 1.538 |
| 36 | GLN | 286 | ILE | 1.905 | 0.369 | 1.536 | 1.536 |
| 231 | LYS | 251 | THR | 1.534 | 0.000 | 1.534 | 1.534 |
| 148 | PHE | 152 | HIS | 2.322 | 3.848 | -1.526 | 1.526 |
| 97 | THR | 102 | TYR | 6.115 | 7.641 | -1.526 | 1.526 |
| 128 | LEU | 257 | MET | 0.000 | 1.524 | -1.524 | 1.524 |
| 194 | LEU | 279 | GLN | 5.355 | 3.849 | 1.506 | 1.506 |
| 249 | GLU | 309 | MET | 0.000 | 1.506 | -1.506 | 1.506 |
| 283 | PHE | 288 | MET | 1.501 | 0.000 | 1.501 | 1.501 |
| 48 | ILE | 92 | THR | 2.140 | 0.651 | 1.489 | 1.489 |
| 185 | CYS | 293 | PHE | 0.000 | 1.474 | -1.474 | 1.474 |
| 48 | ILE | 87 | VAL | 0.133 | 1.591 | -1.458 | 1.458 |
| 52 | PHE | 88 | LEU | 0.000 | 1.450 | -1.450 | 1.450 |
| 301 | TYR | 302 | ASN | 2.508 | 3.954 | -1.446 | 1.446 |
| 223 | TYR | 254 | VAL | 2.813 | 4.226 | -1.413 | 1.413 |
| 97 | THR | 105 | PHE | 1.410 | 0.000 | 1.410 | 1.410 |
| 128 | LEU | 219 | ILE | 0.613 | 2.008 | -1.394 | 1.394 |
| 139 | VAL | 226 | LEU | 0.654 | 2.048 | -1.393 | 1.393 |
| 102 | TYR | 104 | VAL | 3.872 | 2.484 | 1.389 | 1.389 |
| 74 | TYR | 150 | GLU | 2.096 | 3.484 | -1.388 | 1.388 |
| 167 | CYS | 211 | HIS | 4.059 | 5.440 | -1.380 | 1.380 |
| 186 | SER | 293 | PHE | 0.000 | 1.371 | -1.371 | 1.371 |
| 286 | ILE | 290 | ILE | 0.000 | 1.350 | -1.350 | 1.350 |
| 9 | PHE | 22 | SER | 3.554 | 4.903 | -1.348 | 1.348 |
| 72 | LEU | 76 | LEU | 0.000 | 1.344 | -1.344 | 1.344 |
| 265 | TRP | 295 | ALA | 0.137 | 1.473 | -1.336 | 1.336 |
| 122 | GLU | 125 | LEU | 1.800 | 0.477 | 1.323 | 1.323 |
| 113 | GLU | 187 | CYS | 7.198 | 5.876 | 1.322 | 1.322 |
| 192 | TYR | 288 | MET | 3.217 | 1.900 | 1.317 | 1.317 |
| 24 | PHE | 102 | TYR | 3.082 | 1.767 | 1.316 | 1.316 |
| 140 | CYS | 226 | LEU | 1.678 | 0.363 | 1.315 | 1.315 |
| 137 | VAL | 143 | MET | 1.609 | 0.302 | 1.307 | 1.307 |
| 62 | THR | 68 | LEU | 3.173 | 1.869 | 1.304 | 1.304 |
| 204 | VAL | 208 | PHE | 0.000 | 1.297 | -1.297 | 1.297 |
| 31 | LEU | 285 | PRO | 2.783 | 1.495 | 1.288 | 1.288 |
| 268 | TYR | 295 | ALA | 1.355 | 0.068 | 1.287 | 1.287 |
| 318 | LEU | 326 | ASN | 0.272 | 1.550 | -1.278 | 1.278 |
| 186 | SER | 296 | LYS | 2.026 | 0.764 | 1.262 | 1.262 |
| 208 | PHE | 213 | THR | 5.957 | 4.695 | 1.262 | 1.262 |
| 302 | ASN | 306 | TYR | 1.249 | 0.000 | 1.249 | 1.249 |
| 43 | TYR | 294 | PHE | 0.000 | 1.236 | -1.236 | 1.236 |
| 208 | PHE | 212 | PHE | 1.417 | 0.187 | 1.230 | 1.230 |
| 103 | PHE | 110 | CYS | 5.140 | 3.914 | 1.226 | 1.226 |
| 86 | MET | 296 | LYS | 1.223 | 0.000 | 1.223 | 1.223 |
| 79 | LEU | 306 | TYR | 1.221 | 0.000 | 1.221 | 1.221 |
| 23 | PRO | 28 | GLN | 3.899 | 5.119 | -1.220 | 1.220 |
| 247 | GLU | 248 | LYS | 1.218 | 0.000 | 1.218 | 1.218 |
| 89 | GLY | 112 | LEU | 0.000 | 1.216 | -1.216 | 1.216 |
| 182 | GLY | 289 | THR | 0.923 | 2.133 | -1.210 | 1.210 |
| 52 | PHE | 56 | PHE | 1.209 | 0.000 | 1.209 | 1.209 |
| 94 | THR | 293 | PHE | 0.000 | 1.207 | -1.207 | 1.207 |
| 54 | ILE | 308 | MET | 1.205 | 0.000 | 1.205 | 1.205 |
| 68 | LEU | 316 | CYS | 2.054 | 0.852 | 1.203 | 1.203 |
| 234 | ALA | 247 | GLU | 1.200 | 0.000 | 1.200 | 1.200 |
| 35 | TRP | 39 | MET | 1.100 | 2.298 | -1.198 | 1.198 |
| 249 | GLU | 253 | MET | 1.195 | 0.000 | 1.195 | 1.195 |
| 181 | GLU | 189 | ILE | 0.000 | 1.194 | -1.194 | 1.194 |
| 167 | CYS | 207 | MET | 2.489 | 1.298 | 1.191 | 1.191 |
| 133 | ILE | 222 | CYS | 1.912 | 0.725 | 1.187 | 1.187 |
| 10 | TYR | 280 | GLY | 0.000 | 1.178 | -1.178 | 1.178 |
| 29 | TYR | 100 | HIS | 1.726 | 2.903 | -1.178 | 1.178 |
| 10 | TYR | 179 | ILE | 0.654 | 1.828 | -1.173 | 1.173 |
| 240 | SER | 242 | THR | 0.609 | 1.777 | -1.168 | 1.168 |
| 102 | TYR | 184 | GLN | 1.270 | 0.104 | 1.166 | 1.166 |
| 311 | LYS | 315 | ASN | 1.164 | 0.000 | 1.164 | 1.164 |
| 134 | GLU | 138 | VAL | 0.000 | 1.162 | -1.162 | 1.162 |
| 190 | ASP | 193 | THR | 6.249 | 5.087 | 1.162 | 1.162 |
| 56 | PHE | 84 | LEU | 0.471 | 1.632 | -1.161 | 1.161 |
| 27 | PRO | 29 | TYR | 3.509 | 2.373 | 1.136 | 1.136 |
| 35 | TRP | 36 | GLN | 6.320 | 5.193 | 1.127 | 1.127 |
| 103 | PHE | 113 | GLU | 1.953 | 0.827 | 1.126 | 1.126 |
| 61 | VAL | 68 | LEU | 2.255 | 1.146 | 1.109 | 1.109 |
| 118 | THR | 189 | ILE | 1.112 | 0.007 | 1.105 | 1.105 |
| 71 | PRO | 134 | GLU | 0.000 | 1.103 | -1.103 | 1.103 |
| 102 | TYR | 185 | CYS | 1.101 | 0.000 | 1.101 | 1.101 |
| 267 | PRO | 291 | PRO | 3.109 | 2.009 | 1.100 | 1.100 |
| 339 | LYS | 340 | THR | 1.097 | 0.000 | 1.097 | 1.097 |
| 75 | ILE | 130 | VAL | 2.212 | 1.115 | 1.097 | 1.097 |
| 146 | PHE | 152 | HIS | 5.017 | 3.922 | 1.095 | 1.095 |
| 86 | MET | 295 | ALA | 1.094 | 0.000 | 1.094 | 1.094 |
| 44 | MET | 296 | LYS | 0.140 | 1.229 | -1.089 | 1.089 |
| 192 | TYR | 275 | ILE | 2.835 | 3.922 | -1.087 | 1.087 |
| 126 | TRP | 211 | HIS | 4.009 | 2.928 | 1.081 | 1.081 |
| 45 | PHE | 95 | LEU | 0.533 | 1.612 | -1.080 | 1.080 |
| 76 | LEU | 313 | PHE | 1.075 | 0.000 | 1.075 | 1.075 |
| 2 | ASN | 12 | PRO | 1.159 | 0.086 | 1.074 | 1.074 |
| 83 | ASP | 303 | PRO | 1.973 | 0.913 | 1.060 | 1.060 |
| 181 | GLU | 187 | CYS | 0.263 | 1.320 | -1.057 | 1.057 |
| 115 | PHE | 178 | TYR | 6.111 | 7.162 | -1.052 | 1.052 |
| 8 | ASN | 179 | ILE | 2.630 | 1.582 | 1.048 | 1.048 |
| 192 | TYR | 193 | THR | 1.387 | 0.353 | 1.034 | 1.034 |
| 298 | ALA | 301 | TYR | 2.976 | 1.946 | 1.031 | 1.031 |
| 212 | PHE | 266 | VAL | 1.068 | 0.047 | 1.021 | 1.021 |
| 226 | LEU | 250 | VAL | 1.017 | 0.000 | 1.017 | 1.017 |
| 125 | LEU | 216 | MET | 0.000 | 1.014 | -1.014 | 1.014 |
| 103 | PHE | 109 | GLY | 3.295 | 2.282 | 1.013 | 1.013 |
| 122 | GLU | 126 | TRP | 1.398 | 2.410 | -1.013 | 1.013 |
| 215 | PRO | 261 | PHE | 1.012 | 0.000 | 1.012 | 1.012 |
| 24 | PHE | 103 | PHE | 4.793 | 3.787 | 1.007 | 1.007 |
| 50 | LEU | 300 | ILE | 2.184 | 1.184 | 0.999 | 0.999 |
| 78 | ASN | 157 | VAL | 2.114 | 3.112 | -0.998 | 0.998 |
| 290 | ILE | 294 | PHE | 0.997 | 0.000 | 0.997 | 0.997 |
| 7 | PRO | 177 | ARG | 1.594 | 2.582 | -0.988 | 0.988 |
| 125 | LEU | 126 | TRP | 0.982 | 0.000 | 0.982 | 0.982 |
| 85 | PHE | 120 | GLY | 0.970 | 0.000 | 0.970 | 0.970 |
| 113 | GLU | 186 | SER | 3.111 | 4.069 | -0.958 | 0.958 |
| 27 | PRO | 101 | GLY | 2.744 | 1.786 | 0.958 | 0.958 |
| 20 | VAL | 30 | TYR | 7.748 | 6.792 | 0.956 | 0.956 |
| 73 | ASN | 312 | GLN | 0.952 | 0.000 | 0.952 | 0.952 |
| 32 | ALA | 37 | PHE | 3.305 | 2.354 | 0.951 | 0.951 |
| 101 | GLY | 185 | CYS | 0.947 | 0.000 | 0.947 | 0.947 |
| 41 | ALA | 98 | SER | 3.501 | 2.558 | 0.943 | 0.943 |
| 40 | LEU | 94 | THR | 0.940 | 0.000 | 0.940 | 0.940 |
| 29 | TYR | 34 | PRO | 3.261 | 2.327 | 0.934 | 0.934 |
| 140 | CYS | 225 | GLN | 1.762 | 0.830 | 0.932 | 0.932 |
| 223 | TYR | 258 | VAL | 0.392 | 1.321 | -0.929 | 0.929 |
| 175 | TRP | 206 | TYR | 2.873 | 1.946 | 0.927 | 0.927 |
| 128 | LEU | 258 | VAL | 0.000 | 0.921 | -0.921 | 0.921 |
| 219 | ILE | 258 | VAL | 0.253 | 1.172 | -0.919 | 0.919 |
| 191 | TYR | 204 | VAL | 2.678 | 1.762 | 0.916 | 0.916 |
| 143 | MET | 146 | PHE | 5.321 | 4.408 | 0.912 | 0.912 |
| 206 | TYR | 210 | VAL | 3.863 | 2.960 | 0.903 | 0.903 |
| 318 | LEU | 327 | PRO | 1.151 | 0.248 | 0.903 | 0.903 |
| 72 | LEU | 250 | VAL | 0.000 | 0.900 | -0.900 | 0.900 |
| 19 | VAL | 30 | TYR | 4.197 | 3.301 | 0.896 | 0.896 |
| 43 | TYR | 297 | SER | 2.310 | 1.427 | 0.883 | 0.883 |
| 78 | ASN | 123 | ILE | 2.669 | 1.787 | 0.882 | 0.882 |
| 309 | MET | 314 | ARG | 0.882 | 0.000 | 0.882 | 0.882 |
| 17 | THR | 19 | VAL | 2.830 | 1.950 | 0.880 | 0.880 |
| 298 | ALA | 303 | PRO | 0.879 | 0.000 | 0.879 | 0.879 |
| 191 | TYR | 268 | TYR | 2.736 | 3.604 | -0.868 | 0.868 |
| 138 | VAL | 148 | PHE | 0.861 | 0.000 | 0.861 | 0.861 |
| 189 | ILE | 207 | MET | 0.563 | 1.417 | -0.854 | 0.854 |
| 32 | ALA | 183 | LEU | 0.926 | 1.780 | -0.854 | 0.854 |
| 289 | THR | 293 | PHE | 0.000 | 0.851 | -0.851 | 0.851 |
| 87 | VAL | 91 | PHE | 1.778 | 0.929 | 0.849 | 0.849 |
| 138 | VAL | 247 | GLU | 0.000 | 0.847 | -0.847 | 0.847 |
| 177 | ARG | 193 | THR | 1.484 | 2.329 | -0.844 | 0.844 |
| 171 | PRO | 203 | PHE | 1.776 | 2.620 | -0.844 | 0.844 |
| 233 | ALA | 243 | THR | 0.843 | 0.000 | 0.843 | 0.843 |
| 147 | ARG | 152 | HIS | 1.959 | 1.121 | 0.838 | 0.838 |
| 12 | PRO | 285 | PRO | 4.268 | 3.433 | 0.835 | 0.835 |
| 171 | PRO | 177 | ARG | 4.786 | 3.957 | 0.829 | 0.829 |
| 8 | ASN | 107 | PRO | 0.824 | 0.000 | 0.824 | 0.824 |
| 317 | MET | 321 | ILE | 0.051 | 0.872 | -0.821 | 0.821 |
| 179 | ILE | 188 | GLY | 5.330 | 6.150 | -0.820 | 0.820 |
| 72 | LEU | 253 | MET | 0.000 | 0.819 | -0.819 | 0.819 |
| 163 | MET | 211 | HIS | 2.458 | 3.276 | -0.819 | 0.819 |
| 3 | GLY | 13 | PHE | 4.523 | 3.708 | 0.815 | 0.815 |
| 201 | GLU | 276 | PHE | 2.246 | 1.433 | 0.813 | 0.813 |
| 243 | THR | 341 | GLU | 0.000 | 0.813 | -0.813 | 0.813 |
| 230 | VAL | 250 | VAL | 0.811 | 0.000 | 0.811 | 0.811 |
| 62 | THR | 73 | ASN | 0.000 | 0.810 | -0.810 | 0.810 |
| 83 | ASP | 298 | ALA | 0.304 | 1.113 | -0.809 | 0.809 |
| 95 | LEU | 99 | LEU | 0.167 | 0.976 | -0.809 | 0.809 |
| 166 | ALA | 206 | TYR | 4.525 | 3.716 | 0.809 | 0.809 |
| 40 | LEU | 289 | THR | 0.000 | 0.785 | -0.785 | 0.785 |
| 76 | LEU | 131 | LEU | 0.781 | 0.000 | 0.781 | 0.781 |
| 55 | ASN | 84 | LEU | 1.130 | 1.909 | -0.779 | 0.779 |
| 129 | VAL | 218 | ILE | 1.630 | 0.851 | 0.779 | 0.779 |
| 133 | ILE | 218 | ILE | 1.259 | 0.482 | 0.777 | 0.777 |
| 11 | VAL | 28 | GLN | 1.368 | 0.598 | 0.771 | 0.771 |
| 114 | GLY | 178 | TYR | 8.438 | 7.667 | 0.770 | 0.770 |
| 96 | TYR | 105 | PHE | 3.269 | 4.037 | -0.767 | 0.767 |
| 264 | CYS | 294 | PHE | 1.385 | 2.150 | -0.765 | 0.765 |
| 85 | PHE | 161 | TRP | 0.718 | 1.483 | -0.765 | 0.765 |
| 28 | GLN | 31 | LEU | 2.322 | 1.564 | 0.758 | 0.758 |
| 61 | VAL | 317 | MET | 2.008 | 2.763 | -0.755 | 0.755 |
| 128 | LEU | 302 | ASN | 0.754 | 0.000 | 0.754 | 0.754 |
| 183 | LEU | 286 | ILE | 0.294 | 1.045 | -0.750 | 0.750 |
| 265 | TRP | 301 | TYR | 0.000 | 0.746 | -0.746 | 0.746 |
| 227 | VAL | 251 | THR | 0.740 | 0.000 | 0.740 | 0.740 |
| 276 | PHE | 279 | GLN | 0.000 | 0.740 | -0.740 | 0.740 |
| 242 | THR | 341 | GLU | 0.000 | 0.738 | -0.738 | 0.738 |
| 216 | MET | 262 | LEU | 0.019 | 0.746 | -0.728 | 0.728 |
| 237 | GLN | 239 | GLU | 0.727 | 0.000 | 0.727 | 0.727 |
| 13 | PHE | 31 | LEU | 1.374 | 2.100 | -0.726 | 0.726 |
| 121 | GLY | 261 | PHE | 0.000 | 0.725 | -0.725 | 0.725 |
| 21 | ARG | 30 | TYR | 5.602 | 4.881 | 0.721 | 0.721 |
| 41 | ALA | 99 | LEU | 0.960 | 1.681 | -0.721 | 0.721 |
| 182 | GLY | 285 | PRO | 6.312 | 7.032 | -0.720 | 0.720 |
| 97 | THR | 104 | VAL | 0.715 | 0.000 | 0.715 | 0.715 |
| 51 | GLY | 300 | ILE | 0.696 | 1.399 | -0.702 | 0.702 |
| 10 | TYR | 184 | GLN | 2.631 | 1.930 | 0.700 | 0.700 |
| 74 | TYR | 154 | ILE | 0.566 | 1.265 | -0.699 | 0.699 |
| 131 | LEU | 134 | GLU | 0.000 | 0.695 | -0.695 | 0.695 |
| 346 | ALA | 347 | PRO | 1.142 | 0.447 | 0.695 | 0.695 |
| 208 | PHE | 272 | ALA | 0.000 | 0.693 | -0.693 | 0.693 |
| 332 | GLU | 336 | THR | 0.000 | 0.682 | -0.682 | 0.682 |
| 1 | MET | 14 | SER | 2.726 | 2.044 | 0.682 | 0.682 |
| 150 | GLU | 154 | ILE | 0.680 | 0.000 | 0.680 | 0.680 |
| 263 | ILE | 294 | PHE | 3.792 | 3.114 | 0.678 | 0.678 |
| 24 | PHE | 107 | PRO | 4.050 | 4.728 | -0.678 | 0.678 |
| 344 | GLN | 345 | VAL | 0.677 | 0.000 | 0.677 | 0.677 |
| 223 | TYR | 255 | ILE | 0.000 | 0.676 | -0.676 | 0.676 |
| 181 | GLU | 186 | SER | 5.755 | 5.084 | 0.670 | 0.670 |
| 171 | PRO | 189 | ILE | 0.303 | 0.968 | -0.665 | 0.665 |
| 271 | VAL | 291 | PRO | 1.342 | 0.678 | 0.664 | 0.664 |
| 181 | GLU | 292 | ALA | 0.799 | 0.136 | 0.663 | 0.663 |
| 179 | ILE | 189 | ILE | 0.000 | 0.662 | -0.662 | 0.662 |
| 97 | THR | 184 | GLN | 0.000 | 0.662 | -0.662 | 0.662 |
| 275 | ILE | 287 | PHE | 0.000 | 0.662 | -0.662 | 0.662 |
| 45 | PHE | 49 | VAL | 2.918 | 2.257 | 0.661 | 0.661 |
| 179 | ILE | 190 | ASP | 3.806 | 3.146 | 0.659 | 0.659 |
| 209 | VAL | 214 | ILE | 3.975 | 4.634 | -0.658 | 0.658 |
| 75 | ILE | 157 | VAL | 0.974 | 0.317 | 0.656 | 0.656 |
| 58 | THR | 303 | PRO | 0.000 | 0.655 | -0.655 | 0.655 |
| 125 | LEU | 219 | ILE | 0.000 | 0.652 | -0.652 | 0.652 |
| 176 | SER | 200 | ASN | 4.100 | 3.448 | 0.652 | 0.652 |
| 130 | VAL | 156 | GLY | 2.534 | 1.884 | 0.650 | 0.650 |
| 175 | TRP | 202 | SER | 4.684 | 4.035 | 0.649 | 0.649 |
| 167 | CYS | 189 | ILE | 0.643 | 0.000 | 0.643 | 0.643 |
| 75 | ILE | 160 | THR | 0.641 | 0.000 | 0.641 | 0.641 |
| 190 | ASP | 204 | VAL | 0.174 | 0.814 | -0.640 | 0.640 |
| 287 | PHE | 288 | MET | 0.635 | 0.000 | 0.635 | 0.635 |
| 11 | VAL | 31 | LEU | 0.648 | 1.283 | -0.635 | 0.635 |
| 24 | PHE | 110 | CYS | 1.669 | 1.039 | 0.630 | 0.630 |
| 79 | LEU | 128 | LEU | 0.624 | 0.000 | 0.624 | 0.624 |
| 326 | ASN | 327 | PRO | 1.246 | 1.870 | -0.624 | 0.624 |
| 26 | TYR | 102 | TYR | 9.254 | 8.630 | 0.624 | 0.624 |
| 253 | MET | 257 | MET | 0.428 | 1.051 | -0.623 | 0.623 |
| 253 | MET | 305 | ILE | 0.918 | 0.295 | 0.623 | 0.623 |
| 43 | TYR | 44 | MET | 1.299 | 0.679 | 0.620 | 0.620 |
| 167 | CYS | 203 | PHE | 1.440 | 2.060 | -0.620 | 0.620 |
| 98 | SER | 293 | PHE | 0.000 | 0.615 | -0.615 | 0.615 |
| 206 | TYR | 211 | HIS | 6.940 | 6.326 | 0.614 | 0.614 |
| 57 | LEU | 317 | MET | 2.824 | 2.213 | 0.612 | 0.612 |
| 137 | VAL | 146 | PHE | 2.176 | 1.565 | 0.611 | 0.611 |
| 129 | VAL | 219 | ILE | 1.886 | 2.494 | -0.608 | 0.608 |
| 73 | ASN | 76 | LEU | 0.604 | 0.000 | 0.604 | 0.604 |
| 216 | MET | 220 | PHE | 1.315 | 0.713 | 0.603 | 0.603 |
| 75 | ILE | 78 | ASN | 0.592 | 0.000 | 0.592 | 0.592 |
| 55 | ASN | 80 | ALA | 5.008 | 4.419 | 0.590 | 0.590 |
| 55 | ASN | 299 | ALA | 1.981 | 2.569 | -0.588 | 0.588 |
| 132 | ALA | 223 | TYR | 4.540 | 3.953 | 0.587 | 0.587 |
| 191 | TYR | 271 | VAL | 0.581 | 0.000 | 0.581 | 0.581 |
| 177 | ARG | 198 | VAL | 0.578 | 0.000 | 0.578 | 0.578 |
| 216 | MET | 219 | ILE | 0.000 | 0.576 | -0.576 | 0.576 |
| 90 | GLY | 112 | LEU | 0.000 | 0.575 | -0.575 | 0.575 |
| 9 | PHE | 23 | PRO | 6.458 | 5.884 | 0.575 | 0.575 |
| 168 | ALA | 178 | TYR | 5.181 | 4.610 | 0.571 | 0.571 |
| 55 | ASN | 303 | PRO | 3.255 | 2.685 | 0.570 | 0.570 |
| 122 | GLU | 207 | MET | 0.565 | 0.000 | 0.565 | 0.565 |
| 160 | THR | 161 | TRP | 1.293 | 0.733 | 0.560 | 0.560 |
| 135 | ARG | 254 | VAL | 0.000 | 0.553 | -0.553 | 0.553 |
| 336 | THR | 340 | THR | 0.000 | 0.553 | -0.553 | 0.553 |
| 74 | TYR | 153 | ALA | 1.576 | 2.127 | -0.551 | 0.551 |
| 86 | MET | 299 | ALA | 0.550 | 0.000 | 0.550 | 0.550 |
| 81 | VAL | 161 | TRP | 0.000 | 0.550 | -0.550 | 0.550 |
| 191 | TYR | 208 | PHE | 0.000 | 0.550 | -0.550 | 0.550 |
| 189 | ILE | 203 | PHE | 2.069 | 2.616 | -0.546 | 0.546 |
| 110 | CYS | 178 | TYR | 1.750 | 2.296 | -0.546 | 0.546 |
| 6 | GLY | 195 | LYS | 0.546 | 0.000 | 0.546 | 0.546 |
| 118 | THR | 168 | ALA | 1.410 | 1.951 | -0.541 | 0.541 |
| 113 | GLU | 117 | ALA | 0.538 | 0.000 | 0.538 | 0.538 |
| 22 | SER | 28 | GLN | 1.531 | 2.068 | -0.537 | 0.537 |
| 195 | LYS | 198 | VAL | 1.043 | 1.575 | -0.532 | 0.532 |
| 100 | HIS | 104 | VAL | 2.934 | 2.407 | 0.526 | 0.526 |
| 72 | LEU | 138 | VAL | 0.525 | 0.000 | 0.525 | 0.525 |
| 31 | LEU | 32 | ALA | 0.525 | 0.000 | 0.525 | 0.525 |
| 32 | ALA | 36 | GLN | 1.460 | 1.985 | -0.525 | 0.525 |
| 126 | TRP | 160 | THR | 4.184 | 3.660 | 0.524 | 0.524 |
| 144 | SER | 145 | ASN | 2.012 | 2.532 | -0.519 | 0.519 |
| 40 | LEU | 98 | SER | 2.222 | 1.705 | 0.517 | 0.517 |
| 114 | GLY | 187 | CYS | 1.880 | 2.395 | -0.515 | 0.515 |
| 315 | ASN | 328 | LEU | 0.512 | 0.001 | 0.510 | 0.510 |
| 56 | PHE | 60 | TYR | 0.508 | 0.000 | 0.508 | 0.508 |
| 79 | LEU | 257 | MET | 0.000 | 0.508 | -0.508 | 0.508 |
| 72 | LEU | 310 | ASN | 0.000 | 0.506 | -0.506 | 0.506 |
| 123 | ILE | 160 | THR | 1.796 | 1.292 | 0.504 | 0.504 |
| 126 | TRP | 159 | PHE | 2.388 | 2.888 | -0.500 | 0.500 |
| 304 | VAL | 308 | MET | 0.664 | 0.165 | 0.499 | 0.499 |
| 119 | LEU | 164 | ALA | 2.230 | 1.732 | 0.499 | 0.499 |
| 40 | LEU | 44 | MET | 0.497 | 0.000 | 0.497 | 0.497 |
| 265 | TRP | 268 | TYR | 0.065 | 0.562 | -0.497 | 0.497 |
| 52 | PHE | 84 | LEU | 1.264 | 1.759 | -0.496 | 0.496 |
| 181 | GLU | 191 | TYR | 0.120 | 0.614 | -0.494 | 0.494 |
| 179 | ILE | 180 | PRO | 0.905 | 1.399 | -0.494 | 0.494 |
| 24 | PHE | 106 | GLY | 4.496 | 4.990 | -0.494 | 0.494 |
| 9 | PHE | 177 | ARG | 0.549 | 0.056 | 0.493 | 0.493 |
| 126 | TRP | 163 | MET | 10.752 | 10.261 | 0.492 | 0.492 |
| 99 | LEU | 100 | HIS | 0.000 | 0.491 | -0.491 | 0.491 |
| 90 | GLY | 117 | ALA | 0.489 | 0.000 | 0.489 | 0.489 |
| 55 | ASN | 83 | ASP | 6.092 | 5.603 | 0.489 | 0.489 |
| 278 | HIS | 281 | SER | 0.820 | 1.308 | -0.489 | 0.489 |
| 65 | HIS | 319 | THR | 0.831 | 0.343 | 0.488 | 0.488 |
| 3 | GLY | 14 | SER | 0.598 | 0.113 | 0.485 | 0.485 |
| 135 | ARG | 306 | TYR | 0.485 | 0.000 | 0.485 | 0.485 |
| 48 | ILE | 53 | PRO | 0.897 | 0.418 | 0.479 | 0.479 |
| 78 | ASN | 161 | TRP | 3.356 | 3.834 | -0.478 | 0.478 |
| 86 | MET | 117 | ALA | 0.336 | 0.812 | -0.476 | 0.476 |
| 206 | TYR | 207 | MET | 0.475 | 0.000 | 0.475 | 0.475 |
| 83 | ASP | 124 | ALA | 0.474 | 0.000 | 0.474 | 0.474 |
| 305 | ILE | 309 | MET | 0.146 | 0.617 | -0.471 | 0.471 |
| 11 | VAL | 23 | PRO | 0.784 | 0.313 | 0.471 | 0.471 |
| 44 | MET | 94 | THR | 3.446 | 2.978 | 0.468 | 0.468 |
| 210 | VAL | 211 | HIS | 2.167 | 2.633 | -0.467 | 0.467 |
| 54 | ILE | 317 | MET | 0.465 | 0.000 | 0.465 | 0.465 |
| 43 | TYR | 46 | LEU | 0.461 | 0.000 | 0.461 | 0.461 |
| 64 | GLN | 69 | ARG | 0.459 | 0.000 | 0.459 | 0.459 |
| 23 | PRO | 103 | PHE | 4.609 | 4.157 | 0.452 | 0.452 |
| 242 | THR | 243 | THR | 0.000 | 0.452 | -0.452 | 0.452 |
| 28 | GLN | 30 | TYR | 6.821 | 6.370 | 0.451 | 0.451 |
| 91 | PHE | 296 | LYS | 5.918 | 5.471 | 0.447 | 0.447 |
| 319 | THR | 324 | GLY | 4.083 | 4.528 | -0.446 | 0.446 |
| 21 | ARG | 26 | TYR | 3.008 | 2.564 | 0.444 | 0.444 |
| 297 | SER | 301 | TYR | 1.335 | 0.893 | 0.442 | 0.442 |
| 273 | PHE | 277 | THR | 2.008 | 1.570 | 0.438 | 0.438 |
| 76 | LEU | 310 | ASN | 0.438 | 0.000 | 0.438 | 0.438 |
| 186 | SER | 292 | ALA | 0.000 | 0.437 | -0.437 | 0.437 |
| 141 | LYS | 239 | GLU | 0.000 | 0.436 | -0.436 | 0.436 |
| 115 | PHE | 168 | ALA | 3.815 | 4.250 | -0.435 | 0.435 |
| 293 | PHE | 297 | SER | 0.434 | 0.000 | 0.434 | 0.434 |
| 115 | PHE | 116 | PHE | 3.553 | 3.120 | 0.433 | 0.433 |
| 230 | VAL | 246 | ALA | 0.432 | 0.000 | 0.432 | 0.432 |
| 326 | ASN | 330 | ASP | 0.225 | 0.655 | -0.430 | 0.430 |
| 75 | ILE | 156 | GLY | 0.421 | 0.000 | 0.421 | 0.421 |
| 181 | GLU | 296 | LYS | 0.420 | 0.000 | 0.420 | 0.420 |
| 65 | HIS | 320 | THR | 2.063 | 2.480 | -0.418 | 0.418 |
| 341 | GLU | 342 | THR | 0.418 | 0.000 | 0.418 | 0.418 |
| 83 | ASP | 299 | ALA | 5.846 | 5.430 | 0.417 | 0.417 |
| 47 | LEU | 300 | ILE | 2.054 | 2.469 | -0.415 | 0.415 |
| 90 | GLY | 113 | GLU | 1.731 | 2.145 | -0.414 | 0.414 |
| 139 | VAL | 230 | VAL | 0.220 | 0.632 | -0.413 | 0.413 |
| 326 | ASN | 328 | LEU | 1.641 | 1.230 | 0.411 | 0.411 |
| 96 | TYR | 104 | VAL | 1.219 | 1.628 | -0.409 | 0.409 |
| 134 | GLU | 153 | ALA | 0.409 | 0.000 | 0.409 | 0.409 |
| 103 | PHE | 184 | GLN | 2.638 | 3.047 | -0.409 | 0.409 |
| 4 | THR | 13 | PHE | 3.543 | 3.951 | -0.408 | 0.408 |
| 77 | LEU | 313 | PHE | 0.407 | 0.000 | 0.407 | 0.407 |
| 175 | TRP | 199 | ASN | 2.575 | 2.170 | 0.405 | 0.405 |
| 189 | ILE | 204 | VAL | 0.000 | 0.405 | -0.405 | 0.405 |
| 136 | TYR | 225 | GLN | 2.108 | 1.703 | 0.405 | 0.405 |
| 63 | VAL | 77 | LEU | 0.000 | 0.405 | -0.405 | 0.405 |
| 124 | ALA | 261 | PHE | 0.000 | 0.404 | -0.404 | 0.404 |
| 31 | LEU | 37 | PHE | 0.403 | 0.000 | 0.403 | 0.403 |
| 119 | LEU | 168 | ALA | 1.450 | 1.852 | -0.401 | 0.401 |
| 12 | PRO | 184 | GLN | 1.776 | 1.379 | 0.397 | 0.397 |
| 76 | LEU | 79 | LEU | 0.000 | 0.397 | -0.397 | 0.397 |
| 118 | THR | 178 | TYR | 4.042 | 3.647 | 0.395 | 0.395 |
| 9 | PHE | 180 | PRO | 0.527 | 0.132 | 0.395 | 0.395 |
| 72 | LEU | 134 | GLU | 0.394 | 0.000 | 0.394 | 0.394 |
| 220 | PHE | 262 | LEU | 0.972 | 0.582 | 0.390 | 0.390 |
| 265 | TRP | 298 | ALA | 0.000 | 0.389 | -0.389 | 0.389 |
| 126 | TRP | 215 | PRO | 2.218 | 2.605 | -0.388 | 0.388 |
| 93 | SER | 113 | GLU | 1.913 | 1.528 | 0.385 | 0.385 |
| 236 | GLN | 238 | GLN | 0.000 | 0.385 | -0.385 | 0.385 |
| 59 | LEU | 77 | LEU | 1.426 | 1.809 | -0.382 | 0.382 |
| 318 | LEU | 325 | LYS | 0.929 | 0.547 | 0.382 | 0.382 |
| 266 | VAL | 270 | SER | 1.008 | 0.626 | 0.382 | 0.382 |
| 65 | HIS | 68 | LEU | 0.682 | 1.061 | -0.379 | 0.379 |
| 175 | TRP | 198 | VAL | 2.571 | 2.192 | 0.379 | 0.379 |
| 171 | PRO | 178 | TYR | 4.066 | 3.687 | 0.379 | 0.379 |
| 232 | GLU | 236 | GLN | 2.168 | 2.544 | -0.376 | 0.376 |
| 301 | TYR | 305 | ILE | 0.325 | 0.700 | -0.376 | 0.376 |
| 281 | SER | 283 | PHE | 1.923 | 1.548 | 0.374 | 0.374 |
| 130 | VAL | 160 | THR | 0.867 | 0.494 | 0.374 | 0.374 |
| 21 | ARG | 28 | GLN | 3.202 | 3.574 | -0.371 | 0.371 |
| 287 | PHE | 290 | ILE | 0.369 | 0.000 | 0.369 | 0.369 |
| 33 | GLU | 35 | TRP | 3.409 | 3.777 | -0.368 | 0.368 |
| 193 | THR | 200 | ASN | 4.165 | 3.798 | 0.367 | 0.367 |
| 300 | ILE | 304 | VAL | 0.103 | 0.470 | -0.367 | 0.367 |
| 139 | VAL | 247 | GLU | 0.000 | 0.366 | -0.366 | 0.366 |
| 23 | PRO | 180 | PRO | 1.189 | 0.825 | 0.364 | 0.364 |
| 294 | PHE | 297 | SER | 0.000 | 0.363 | -0.363 | 0.363 |
| 58 | THR | 77 | LEU | 0.363 | 0.000 | 0.363 | 0.363 |
| 12 | PRO | 182 | GLY | 1.147 | 1.508 | -0.361 | 0.361 |
| 79 | LEU | 302 | ASN | 0.690 | 0.329 | 0.361 | 0.361 |
| 117 | ALA | 265 | TRP | 0.000 | 0.358 | -0.358 | 0.358 |
| 24 | PHE | 180 | PRO | 3.421 | 3.062 | 0.358 | 0.358 |
| 314 | ARG | 315 | ASN | 0.479 | 0.122 | 0.357 | 0.357 |
| 87 | VAL | 88 | LEU | 0.354 | 0.000 | 0.354 | 0.354 |
| 10 | TYR | 281 | SER | 0.000 | 0.351 | -0.351 | 0.351 |
| 163 | MET | 210 | VAL | 0.588 | 0.237 | 0.350 | 0.350 |
| 254 | VAL | 257 | MET | 0.411 | 0.065 | 0.346 | 0.346 |
| 44 | MET | 47 | LEU | 1.066 | 0.722 | 0.344 | 0.344 |
| 112 | LEU | 116 | PHE | 0.311 | 0.654 | -0.343 | 0.343 |
| 117 | ALA | 296 | LYS | 0.000 | 0.342 | -0.342 | 0.342 |
| 72 | LEU | 131 | LEU | 0.000 | 0.340 | -0.340 | 0.340 |
| 178 | TYR | 189 | ILE | 2.418 | 2.078 | 0.340 | 0.340 |
| 72 | LEU | 135 | ARG | 0.000 | 0.338 | -0.338 | 0.338 |
| 28 | GLN | 102 | TYR | 0.622 | 0.288 | 0.334 | 0.334 |
| 28 | GLN | 101 | GLY | 3.963 | 4.295 | -0.332 | 0.332 |
| 126 | TRP | 129 | VAL | 1.899 | 1.568 | 0.331 | 0.331 |
| 75 | ILE | 79 | LEU | 0.000 | 0.331 | -0.331 | 0.331 |
| 332 | GLU | 335 | ALA | 0.000 | 0.331 | -0.331 | 0.331 |
| 255 | ILE | 259 | ILE | 0.969 | 0.641 | 0.328 | 0.328 |
| 210 | VAL | 215 | PRO | 2.313 | 2.640 | -0.327 | 0.327 |
| 127 | SER | 160 | THR | 2.750 | 3.075 | -0.325 | 0.325 |
| 119 | LEU | 161 | TRP | 0.000 | 0.324 | -0.324 | 0.324 |
| 70 | THR | 71 | PRO | 0.826 | 1.148 | -0.322 | 0.322 |
| 179 | ILE | 187 | CYS | 4.363 | 4.683 | -0.320 | 0.320 |
| 178 | TYR | 188 | GLY | 5.047 | 5.366 | -0.319 | 0.319 |
| 207 | MET | 208 | PHE | 0.000 | 0.319 | -0.319 | 0.319 |
| 139 | VAL | 229 | THR | 0.547 | 0.865 | -0.319 | 0.319 |
| 132 | ALA | 226 | LEU | 0.000 | 0.318 | -0.318 | 0.318 |
| 124 | ALA | 302 | ASN | 0.000 | 0.317 | -0.317 | 0.317 |
| 237 | GLN | 240 | SER | 0.316 | 0.000 | 0.316 | 0.316 |
| 8 | ASN | 180 | PRO | 0.558 | 0.243 | 0.315 | 0.315 |
| 303 | PRO | 307 | ILE | 0.476 | 0.163 | 0.313 | 0.313 |
| 263 | ILE | 301 | TYR | 0.311 | 0.000 | 0.311 | 0.311 |
| 257 | MET | 305 | ILE | 0.604 | 0.914 | -0.311 | 0.311 |
| 31 | LEU | 183 | LEU | 1.594 | 1.904 | -0.310 | 0.310 |
| 262 | LEU | 266 | VAL | 1.466 | 1.157 | 0.309 | 0.309 |
| 264 | CYS | 298 | ALA | 0.771 | 1.078 | -0.307 | 0.307 |
| 286 | ILE | 289 | THR | 0.304 | 0.000 | 0.304 | 0.304 |
| 214 | ILE | 218 | ILE | 0.924 | 0.623 | 0.301 | 0.301 |
| 93 | SER | 103 | PHE | 0.250 | 0.549 | -0.300 | 0.300 |
| 9 | PHE | 24 | PHE | 1.165 | 0.867 | 0.298 | 0.298 |
| 170 | PRO | 175 | TRP | 8.264 | 7.966 | 0.298 | 0.298 |
| 223 | TYR | 306 | TYR | 0.297 | 0.000 | 0.297 | 0.297 |
| 31 | LEU | 182 | GLY | 0.069 | 0.366 | -0.297 | 0.297 |
| 131 | LEU | 257 | MET | 0.000 | 0.297 | -0.297 | 0.297 |
| 37 | PHE | 98 | SER | 3.354 | 3.061 | 0.293 | 0.293 |
| 7 | PRO | 8 | ASN | 0.585 | 0.292 | 0.293 | 0.293 |
| 44 | MET | 95 | LEU | 2.034 | 1.743 | 0.291 | 0.291 |
| 221 | PHE | 225 | GLN | 2.280 | 1.989 | 0.291 | 0.291 |
| 29 | TYR | 99 | LEU | 0.158 | 0.448 | -0.291 | 0.291 |
| 182 | GLY | 192 | TYR | 0.000 | 0.291 | -0.291 | 0.291 |
| 51 | GLY | 299 | ALA | 0.599 | 0.309 | 0.290 | 0.290 |
| 64 | GLN | 65 | HIS | 0.857 | 0.569 | 0.288 | 0.288 |
| 6 | GLY | 177 | ARG | 0.286 | 0.000 | 0.286 | 0.286 |
| 274 | TYR | 281 | SER | 0.000 | 0.280 | -0.280 | 0.280 |
| 275 | ILE | 288 | MET | 0.782 | 0.503 | 0.279 | 0.279 |
| 52 | PHE | 87 | VAL | 1.086 | 1.365 | -0.278 | 0.278 |
| 252 | ARG | 256 | ILE | 0.607 | 0.333 | 0.275 | 0.275 |
| 118 | THR | 167 | CYS | 0.688 | 0.414 | 0.274 | 0.274 |
| 271 | VAL | 275 | ILE | 0.946 | 0.674 | 0.272 | 0.272 |
| 126 | TRP | 214 | ILE | 0.270 | 0.000 | 0.270 | 0.270 |
| 261 | PHE | 262 | LEU | 0.270 | 0.000 | 0.270 | 0.270 |
| 191 | TYR | 291 | PRO | 0.270 | 0.000 | 0.270 | 0.270 |
| 302 | ASN | 307 | ILE | 0.269 | 0.000 | 0.269 | 0.269 |
| 59 | LEU | 63 | VAL | 0.000 | 0.268 | -0.268 | 0.268 |
| 126 | TRP | 210 | VAL | 1.864 | 1.597 | 0.267 | 0.267 |
| 61 | VAL | 65 | HIS | 0.374 | 0.640 | -0.266 | 0.266 |
| 228 | PHE | 232 | GLU | 1.896 | 1.630 | 0.265 | 0.265 |
| 182 | GLY | 288 | MET | 1.140 | 0.878 | 0.262 | 0.262 |
| 8 | ASN | 24 | PHE | 2.252 | 2.514 | -0.262 | 0.262 |
| 290 | ILE | 291 | PRO | 1.145 | 1.406 | -0.261 | 0.261 |
| 87 | VAL | 299 | ALA | 0.000 | 0.260 | -0.260 | 0.260 |
| 57 | LEU | 320 | THR | 0.259 | 0.000 | 0.259 | 0.259 |
| 98 | SER | 185 | CYS | 2.632 | 2.373 | 0.259 | 0.259 |
| 11 | VAL | 184 | GLN | 1.523 | 1.264 | 0.259 | 0.259 |
| 115 | PHE | 169 | ALA | 0.719 | 0.976 | -0.258 | 0.258 |
| 252 | ARG | 253 | MET | 0.255 | 0.000 | 0.255 | 0.255 |
| 47 | LEU | 296 | LYS | 1.815 | 2.070 | -0.255 | 0.255 |
| 188 | GLY | 268 | TYR | 0.000 | 0.253 | -0.253 | 0.253 |
| 94 | THR | 296 | LYS | 0.647 | 0.899 | -0.252 | 0.252 |
| 57 | LEU | 61 | VAL | 1.040 | 0.790 | 0.250 | 0.250 |
| 61 | VAL | 62 | THR | 0.248 | 0.000 | 0.248 | 0.248 |
| 322 | CYS | 325 | LYS | 0.244 | 0.000 | 0.244 | 0.244 |
| 212 | PHE | 213 | THR | 0.528 | 0.284 | 0.244 | 0.244 |
| 59 | LEU | 81 | VAL | 0.754 | 0.510 | 0.244 | 0.244 |
| 76 | LEU | 253 | MET | 0.000 | 0.243 | -0.243 | 0.243 |
| 54 | ILE | 307 | ILE | 0.000 | 0.243 | -0.243 | 0.243 |
| 253 | MET | 256 | ILE | 0.243 | 0.000 | 0.243 | 0.243 |
| 37 | PHE | 183 | LEU | 2.166 | 2.408 | -0.241 | 0.241 |
| 315 | ASN | 331 | ASP | 0.000 | 0.241 | -0.241 | 0.241 |
| 23 | PRO | 184 | GLN | 3.058 | 2.818 | 0.241 | 0.241 |
| 308 | MET | 317 | MET | 0.239 | 0.000 | 0.239 | 0.239 |
| 226 | LEU | 230 | VAL | 0.237 | 0.000 | 0.237 | 0.237 |
| 242 | THR | 337 | VAL | 0.000 | 0.236 | -0.236 | 0.236 |
| 310 | ASN | 312 | GLN | 0.871 | 1.107 | -0.235 | 0.235 |
| 26 | TYR | 27 | PRO | 0.999 | 0.763 | 0.235 | 0.235 |
| 10 | TYR | 12 | PRO | 0.376 | 0.141 | 0.235 | 0.235 |
| 254 | VAL | 258 | VAL | 0.233 | 0.000 | 0.233 | 0.233 |
| 148 | PHE | 153 | ALA | 3.589 | 3.357 | 0.231 | 0.231 |
| 61 | VAL | 316 | CYS | 1.115 | 1.345 | -0.230 | 0.230 |
| 125 | LEU | 212 | PHE | 0.000 | 0.229 | -0.229 | 0.229 |
| 7 | PRO | 195 | LYS | 1.486 | 1.713 | -0.227 | 0.227 |
| 27 | PRO | 100 | HIS | 1.847 | 1.620 | 0.227 | 0.227 |
| 288 | MET | 291 | PRO | 0.000 | 0.226 | -0.226 | 0.226 |
| 278 | HIS | 283 | PHE | 0.081 | 0.302 | -0.220 | 0.220 |
| 33 | GLU | 34 | PRO | 1.529 | 1.308 | 0.220 | 0.220 |
| 226 | LEU | 254 | VAL | 0.220 | 0.000 | 0.220 | 0.220 |
| 88 | LEU | 92 | THR | 0.220 | 0.000 | 0.220 | 0.220 |
| 130 | VAL | 159 | PHE | 0.951 | 0.732 | 0.219 | 0.219 |
| 103 | PHE | 187 | CYS | 3.249 | 3.468 | -0.219 | 0.219 |
| 302 | ASN | 303 | PRO | 0.926 | 1.144 | -0.219 | 0.219 |
| 62 | THR | 313 | PHE | 1.261 | 1.478 | -0.218 | 0.218 |
| 61 | VAL | 320 | THR | 1.428 | 1.644 | -0.217 | 0.217 |
| 135 | ARG | 251 | THR | 0.000 | 0.216 | -0.216 | 0.216 |
| 94 | THR | 97 | THR | 0.214 | 0.000 | 0.214 | 0.214 |
| 51 | GLY | 87 | VAL | 0.806 | 0.593 | 0.213 | 0.213 |
| 25 | GLU | 102 | TYR | 6.000 | 6.213 | -0.213 | 0.213 |
| 103 | PHE | 185 | CYS | 2.309 | 2.521 | -0.212 | 0.212 |
| 176 | SER | 203 | PHE | 5.013 | 4.801 | 0.212 | 0.212 |
| 70 | THR | 72 | LEU | 0.239 | 0.450 | -0.210 | 0.210 |
| 11 | VAL | 21 | ARG | 0.484 | 0.275 | 0.209 | 0.209 |
| 70 | THR | 73 | ASN | 2.984 | 3.191 | -0.207 | 0.207 |
| 3 | GLY | 11 | VAL | 2.136 | 1.931 | 0.205 | 0.205 |
| 172 | LEU | 178 | TYR | 1.894 | 1.689 | 0.205 | 0.205 |
| 195 | LYS | 197 | GLU | 2.801 | 2.597 | 0.204 | 0.204 |
| 264 | CYS | 297 | SER | 0.000 | 0.200 | -0.200 | 0.200 |
| 57 | LEU | 60 | TYR | 0.199 | 0.000 | 0.199 | 0.199 |
| 94 | THR | 98 | SER | 0.000 | 0.199 | -0.199 | 0.199 |
| 123 | ILE | 161 | TRP | 2.939 | 3.138 | -0.198 | 0.198 |
| 79 | LEU | 123 | ILE | 0.000 | 0.196 | -0.196 | 0.196 |
| 122 | GLU | 265 | TRP | 0.192 | 0.000 | 0.192 | 0.192 |
| 264 | CYS | 301 | TYR | 3.988 | 3.797 | 0.191 | 0.191 |
| 33 | GLU | 36 | GLN | 1.729 | 1.538 | 0.190 | 0.190 |
| 258 | VAL | 262 | LEU | 0.384 | 0.573 | -0.189 | 0.189 |
| 3 | GLY | 10 | TYR | 3.514 | 3.702 | -0.188 | 0.188 |
| 47 | LEU | 52 | PHE | 0.343 | 0.157 | 0.186 | 0.186 |
| 221 | PHE | 222 | CYS | 0.388 | 0.204 | 0.184 | 0.184 |
| 177 | ARG | 200 | ASN | 0.515 | 0.698 | -0.183 | 0.183 |
| 314 | ARG | 318 | LEU | 0.406 | 0.224 | 0.181 | 0.181 |
| 174 | GLY | 197 | GLU | 0.195 | 0.016 | 0.179 | 0.179 |
| 189 | ILE | 268 | TYR | 0.000 | 0.178 | -0.178 | 0.178 |
| 176 | SER | 189 | ILE | 0.804 | 0.982 | -0.178 | 0.178 |
| 46 | LEU | 300 | ILE | 0.177 | 0.000 | 0.177 | 0.177 |
| 177 | ARG | 189 | ILE | 1.319 | 1.142 | 0.177 | 0.177 |
| 122 | GLU | 164 | ALA | 2.729 | 2.906 | -0.177 | 0.177 |
| 47 | LEU | 297 | SER | 0.677 | 0.502 | 0.175 | 0.175 |
| 166 | ALA | 211 | HIS | 0.726 | 0.551 | 0.174 | 0.174 |
| 37 | PHE | 185 | CYS | 1.466 | 1.640 | -0.174 | 0.174 |
| 74 | TYR | 157 | VAL | 1.115 | 1.289 | -0.174 | 0.174 |
| 81 | VAL | 85 | PHE | 1.032 | 1.206 | -0.174 | 0.174 |
| 171 | PRO | 176 | SER | 4.042 | 3.871 | 0.171 | 0.171 |
| 212 | PHE | 216 | MET | 0.381 | 0.213 | 0.168 | 0.168 |
| 4 | THR | 14 | SER | 0.821 | 0.989 | -0.168 | 0.168 |
| 15 | ASN | 20 | VAL | 9.122 | 8.955 | 0.167 | 0.167 |
| 277 | THR | 278 | HIS | 3.359 | 3.194 | 0.165 | 0.165 |
| 159 | PHE | 163 | MET | 3.663 | 3.828 | -0.165 | 0.165 |
| 58 | THR | 80 | ALA | 1.037 | 0.873 | 0.164 | 0.164 |
| 129 | VAL | 133 | ILE | 0.369 | 0.532 | -0.163 | 0.163 |
| 118 | THR | 122 | GLU | 0.395 | 0.234 | 0.161 | 0.161 |
| 23 | PRO | 102 | TYR | 4.015 | 3.856 | 0.158 | 0.158 |
| 8 | ASN | 178 | TYR | 0.157 | 0.000 | 0.157 | 0.157 |
| 76 | LEU | 257 | MET | 0.000 | 0.157 | -0.157 | 0.157 |
| 4 | THR | 9 | PHE | 1.058 | 1.215 | -0.157 | 0.157 |
| 7 | PRO | 9 | PHE | 0.256 | 0.099 | 0.157 | 0.157 |
| 259 | ILE | 263 | ILE | 1.042 | 0.886 | 0.155 | 0.155 |
| 2 | ASN | 10 | TYR | 0.259 | 0.106 | 0.153 | 0.153 |
| 209 | VAL | 215 | PRO | 0.018 | 0.171 | -0.153 | 0.153 |
| 170 | PRO | 203 | PHE | 1.261 | 1.414 | -0.152 | 0.152 |
| 59 | LEU | 80 | ALA | 0.602 | 0.450 | 0.152 | 0.152 |
| 11 | VAL | 13 | PHE | 0.400 | 0.551 | -0.152 | 0.152 |
| 132 | ALA | 222 | CYS | 3.109 | 2.957 | 0.152 | 0.152 |
| 195 | LYS | 196 | PRO | 0.316 | 0.168 | 0.148 | 0.148 |
| 13 | PHE | 20 | VAL | 1.490 | 1.342 | 0.147 | 0.147 |
| 177 | ARG | 188 | GLY | 0.810 | 0.957 | -0.147 | 0.147 |
| 29 | TYR | 101 | GLY | 1.617 | 1.762 | -0.144 | 0.144 |
| 91 | PHE | 299 | ALA | 1.344 | 1.200 | 0.144 | 0.144 |
| 199 | ASN | 202 | SER | 0.960 | 1.099 | -0.138 | 0.138 |
| 288 | MET | 292 | ALA | 0.000 | 0.138 | -0.138 | 0.138 |
| 49 | VAL | 50 | LEU | 0.000 | 0.138 | -0.138 | 0.138 |
| 22 | SER | 23 | PRO | 1.255 | 1.117 | 0.137 | 0.137 |
| 79 | LEU | 127 | SER | 1.605 | 1.469 | 0.136 | 0.136 |
| 3 | GLY | 12 | PRO | 0.428 | 0.292 | 0.136 | 0.136 |
| 180 | PRO | 187 | CYS | 3.298 | 3.433 | -0.135 | 0.135 |
| 253 | MET | 310 | ASN | 0.000 | 0.134 | -0.134 | 0.134 |
| 4 | THR | 11 | VAL | 6.618 | 6.751 | -0.132 | 0.132 |
| 204 | VAL | 272 | ALA | 0.132 | 0.000 | 0.132 | 0.132 |
| 4 | THR | 20 | VAL | 3.159 | 3.290 | -0.131 | 0.131 |
| 60 | TYR | 320 | THR | 1.217 | 1.347 | -0.130 | 0.130 |
| 140 | CYS | 142 | PRO | 0.162 | 0.032 | 0.130 | 0.130 |
| 233 | ALA | 238 | GLN | 0.000 | 0.129 | -0.129 | 0.129 |
| 322 | CYS | 327 | PRO | 1.458 | 1.329 | 0.129 | 0.129 |
| 142 | PRO | 143 | MET | 0.129 | 0.000 | 0.129 | 0.129 |
| 218 | ILE | 222 | CYS | 0.446 | 0.318 | 0.128 | 0.128 |
| 190 | ASP | 192 | TYR | 0.964 | 1.091 | -0.127 | 0.127 |
| 116 | PHE | 119 | LEU | 0.128 | 0.254 | -0.126 | 0.126 |
| 136 | TYR | 137 | VAL | 0.341 | 0.214 | 0.126 | 0.126 |
| 75 | ILE | 76 | LEU | 0.123 | 0.000 | 0.123 | 0.123 |
| 165 | LEU | 170 | PRO | 0.943 | 1.065 | -0.122 | 0.122 |
| 40 | LEU | 185 | CYS | 0.768 | 0.650 | 0.118 | 0.118 |
| 129 | VAL | 215 | PRO | 2.126 | 2.011 | 0.115 | 0.115 |
| 48 | ILE | 91 | PHE | 2.517 | 2.631 | -0.114 | 0.114 |
| 11 | VAL | 30 | TYR | 1.487 | 1.601 | -0.114 | 0.114 |
| 261 | PHE | 266 | VAL | 0.072 | 0.185 | -0.114 | 0.114 |
| 121 | GLY | 265 | TRP | 2.077 | 1.964 | 0.113 | 0.113 |
| 134 | GLU | 156 | GLY | 0.113 | 0.000 | 0.113 | 0.113 |
| 128 | LEU | 254 | VAL | 0.000 | 0.112 | -0.112 | 0.112 |
| 181 | GLU | 289 | THR | 0.000 | 0.112 | -0.112 | 0.112 |
| 115 | PHE | 172 | LEU | 2.126 | 2.236 | -0.111 | 0.111 |
| 31 | LEU | 184 | GLN | 0.527 | 0.637 | -0.110 | 0.110 |
| 262 | LEU | 267 | PRO | 0.859 | 0.750 | 0.109 | 0.109 |
| 178 | TYR | 187 | CYS | 0.000 | 0.109 | -0.109 | 0.109 |
| 22 | SER | 24 | PHE | 1.635 | 1.528 | 0.107 | 0.107 |
| 183 | LEU | 185 | CYS | 0.000 | 0.107 | -0.107 | 0.107 |
| 179 | ILE | 193 | THR | 0.107 | 0.000 | 0.107 | 0.107 |
| 58 | THR | 76 | LEU | 0.054 | 0.160 | -0.106 | 0.106 |
| 219 | ILE | 224 | GLY | 0.106 | 0.000 | 0.106 | 0.106 |
| 193 | THR | 195 | LYS | 0.389 | 0.494 | -0.105 | 0.105 |
| 276 | PHE | 277 | THR | 0.112 | 0.216 | -0.104 | 0.104 |
| 210 | VAL | 214 | ILE | 0.104 | 0.000 | 0.104 | 0.104 |
| 190 | ASP | 200 | ASN | 8.666 | 8.563 | 0.103 | 0.103 |
| 140 | CYS | 229 | THR | 2.548 | 2.446 | 0.102 | 0.102 |
| 36 | GLN | 183 | LEU | 0.101 | 0.000 | 0.101 | 0.101 |
| 2 | ASN | 14 | SER | 3.112 | 3.011 | 0.101 | 0.101 |
| 336 | THR | 337 | VAL | 0.101 | 0.000 | 0.101 | 0.101 |
| 108 | THR | 112 | LEU | 0.031 | 0.132 | -0.101 | 0.101 |
| 196 | PRO | 197 | GLU | 0.960 | 1.060 | -0.100 | 0.100 |
| 123 | ILE | 164 | ALA | 2.338 | 2.242 | 0.097 | 0.097 |
| 136 | TYR | 140 | CYS | 2.406 | 2.502 | -0.097 | 0.097 |
| 85 | PHE | 90 | GLY | 0.592 | 0.688 | -0.096 | 0.096 |
| 100 | HIS | 102 | TYR | 0.894 | 0.798 | 0.096 | 0.096 |
| 203 | PHE | 206 | TYR | 0.968 | 1.064 | -0.096 | 0.096 |
| 111 | ASN | 178 | TYR | 3.779 | 3.683 | 0.095 | 0.095 |
| 8 | ASN | 195 | LYS | 0.000 | 0.095 | -0.095 | 0.095 |
| 274 | TYR | 275 | ILE | 0.000 | 0.095 | -0.095 | 0.095 |
| 79 | LEU | 124 | ALA | 1.764 | 1.859 | -0.095 | 0.095 |
| 12 | PRO | 31 | LEU | 0.094 | 0.000 | 0.094 | 0.094 |
| 40 | LEU | 183 | LEU | 0.788 | 0.695 | 0.093 | 0.093 |
| 119 | LEU | 165 | LEU | 1.327 | 1.420 | -0.093 | 0.093 |
| 139 | VAL | 140 | CYS | 0.093 | 0.000 | 0.093 | 0.093 |
| 13 | PHE | 19 | VAL | 0.444 | 0.536 | -0.093 | 0.093 |
| 314 | ARG | 328 | LEU | 0.092 | 0.000 | 0.092 | 0.092 |
| 58 | THR | 62 | THR | 0.000 | 0.092 | -0.092 | 0.092 |
| 251 | THR | 255 | ILE | 0.516 | 0.425 | 0.091 | 0.091 |
| 43 | TYR | 296 | LYS | 0.000 | 0.091 | -0.091 | 0.091 |
| 83 | ASP | 86 | MET | 0.428 | 0.519 | -0.091 | 0.091 |
| 167 | CYS | 178 | TYR | 0.002 | 0.092 | -0.090 | 0.090 |
| 14 | SER | 16 | ALA | 0.707 | 0.797 | -0.090 | 0.090 |
| 93 | SER | 97 | THR | 0.262 | 0.352 | -0.090 | 0.090 |
| 110 | CYS | 180 | PRO | 1.696 | 1.783 | -0.087 | 0.087 |
| 192 | TYR | 280 | GLY | 0.000 | 0.087 | -0.087 | 0.087 |
| 334 | SER | 337 | VAL | 0.087 | 0.000 | 0.087 | 0.087 |
| 268 | TYR | 272 | ALA | 0.000 | 0.086 | -0.086 | 0.086 |
| 293 | PHE | 296 | LYS | 0.000 | 0.085 | -0.085 | 0.085 |
| 256 | ILE | 305 | ILE | 1.523 | 1.439 | 0.084 | 0.084 |
| 240 | SER | 341 | GLU | 0.000 | 0.084 | -0.084 | 0.084 |
| 54 | ILE | 58 | THR | 0.000 | 0.082 | -0.082 | 0.082 |
| 19 | VAL | 20 | VAL | 0.095 | 0.176 | -0.081 | 0.081 |
| 292 | ALA | 296 | LYS | 0.080 | 0.000 | 0.080 | 0.080 |
| 26 | TYR | 101 | GLY | 0.000 | 0.079 | -0.079 | 0.079 |
| 110 | CYS | 187 | CYS | 7.366 | 7.443 | -0.077 | 0.077 |
| 5 | GLU | 10 | TYR | 1.162 | 1.239 | -0.077 | 0.077 |
| 146 | PHE | 148 | PHE | 0.681 | 0.605 | 0.076 | 0.076 |
| 136 | TYR | 141 | LYS | 0.635 | 0.559 | 0.076 | 0.076 |
| 28 | GLN | 183 | LEU | 0.520 | 0.595 | -0.075 | 0.075 |
| 205 | ILE | 209 | VAL | 0.162 | 0.236 | -0.074 | 0.074 |
| 110 | CYS | 179 | ILE | 1.976 | 1.904 | 0.072 | 0.072 |
| 54 | ILE | 303 | PRO | 1.417 | 1.488 | -0.071 | 0.071 |
| 50 | LEU | 54 | ILE | 0.000 | 0.070 | -0.070 | 0.070 |
| 123 | ILE | 127 | SER | 0.421 | 0.491 | -0.070 | 0.070 |
| 212 | PHE | 261 | PHE | 0.070 | 0.000 | 0.070 | 0.070 |
| 286 | ILE | 291 | PRO | 0.000 | 0.069 | -0.069 | 0.069 |
| 119 | LEU | 123 | ILE | 1.165 | 1.097 | 0.068 | 0.068 |
| 4 | THR | 15 | ASN | 3.591 | 3.658 | -0.067 | 0.067 |
| 238 | GLN | 239 | GLU | 0.065 | 0.000 | 0.065 | 0.065 |
| 139 | VAL | 251 | THR | 0.000 | 0.064 | -0.064 | 0.064 |
| 134 | GLU | 152 | HIS | 0.063 | 0.000 | 0.063 | 0.063 |
| 308 | MET | 309 | MET | 0.000 | 0.063 | -0.063 | 0.063 |
| 54 | ILE | 304 | VAL | 0.204 | 0.142 | 0.062 | 0.062 |
| 59 | LEU | 84 | LEU | 0.667 | 0.605 | 0.062 | 0.062 |
| 27 | PRO | 102 | TYR | 6.672 | 6.610 | 0.062 | 0.062 |
| 208 | PHE | 269 | ALA | 2.253 | 2.314 | -0.061 | 0.061 |
| 115 | PHE | 119 | LEU | 0.871 | 0.932 | -0.061 | 0.061 |
| 201 | GLU | 205 | ILE | 0.061 | 0.000 | 0.061 | 0.061 |
| 78 | ASN | 160 | THR | 3.020 | 2.959 | 0.061 | 0.061 |
| 305 | ILE | 310 | ASN | 0.060 | 0.000 | 0.060 | 0.060 |
| 219 | ILE | 223 | TYR | 1.138 | 1.198 | -0.060 | 0.060 |
| 115 | PHE | 165 | LEU | 0.590 | 0.531 | 0.060 | 0.060 |
| 157 | VAL | 161 | TRP | 0.830 | 0.772 | 0.058 | 0.058 |
| 167 | CYS | 206 | TYR | 0.180 | 0.123 | 0.057 | 0.057 |
| 84 | LEU | 89 | GLY | 0.153 | 0.099 | 0.055 | 0.055 |
| 52 | PHE | 57 | LEU | 0.051 | 0.000 | 0.051 | 0.051 |
| 91 | PHE | 94 | THR | 0.000 | 0.050 | -0.050 | 0.050 |
| 28 | GLN | 184 | GLN | 1.421 | 1.371 | 0.050 | 0.050 |
| 11 | VAL | 12 | PRO | 0.985 | 1.035 | -0.050 | 0.050 |
| 67 | LYS | 73 | ASN | 0.049 | 0.000 | 0.049 | 0.049 |
| 125 | LEU | 211 | HIS | 1.788 | 1.740 | 0.049 | 0.049 |
| 137 | VAL | 142 | PRO | 2.646 | 2.598 | 0.048 | 0.048 |
| 135 | ARG | 140 | CYS | 0.264 | 0.217 | 0.047 | 0.047 |
| 133 | ILE | 137 | VAL | 0.257 | 0.210 | 0.047 | 0.047 |
| 4 | THR | 10 | TYR | 2.529 | 2.576 | -0.046 | 0.046 |
| 321 | ILE | 322 | CYS | 0.118 | 0.073 | 0.045 | 0.045 |
| 65 | HIS | 316 | CYS | 10.656 | 10.701 | -0.045 | 0.045 |
| 126 | TRP | 164 | ALA | 0.250 | 0.294 | -0.044 | 0.044 |
| 132 | ALA | 219 | ILE | 0.528 | 0.572 | -0.044 | 0.044 |
| 54 | ILE | 300 | ILE | 0.249 | 0.207 | 0.043 | 0.043 |
| 82 | ALA | 123 | ILE | 2.039 | 1.996 | 0.043 | 0.043 |
| 23 | PRO | 24 | PHE | 0.103 | 0.143 | -0.040 | 0.040 |
| 190 | ASP | 195 | LYS | 0.040 | 0.000 | 0.040 | 0.040 |
| 46 | LEU | 51 | GLY | 0.040 | 0.000 | 0.040 | 0.040 |
| 170 | PRO | 176 | SER | 0.109 | 0.069 | 0.040 | 0.040 |
| 169 | ALA | 170 | PRO | 0.746 | 0.706 | 0.040 | 0.040 |
| 85 | PHE | 119 | LEU | 0.039 | 0.000 | 0.039 | 0.039 |
| 44 | MET | 98 | SER | 0.000 | 0.036 | -0.036 | 0.036 |
| 292 | ALA | 297 | SER | 0.034 | 0.000 | 0.034 | 0.034 |
| 24 | PHE | 25 | GLU | 0.034 | 0.000 | 0.034 | 0.034 |
| 207 | MET | 212 | PHE | 1.832 | 1.799 | 0.033 | 0.033 |
| 227 | VAL | 255 | ILE | 0.000 | 0.031 | -0.031 | 0.031 |
| 55 | ASN | 79 | LEU | 0.000 | 0.030 | -0.030 | 0.030 |
| 209 | VAL | 210 | VAL | 0.169 | 0.139 | 0.030 | 0.030 |
| 13 | PHE | 17 | THR | 0.030 | 0.000 | 0.030 | 0.030 |
| 208 | PHE | 209 | VAL | 0.029 | 0.000 | 0.029 | 0.029 |
| 86 | MET | 120 | GLY | 2.126 | 2.098 | 0.029 | 0.029 |
| 46 | LEU | 50 | LEU | 1.401 | 1.429 | -0.028 | 0.028 |
| 170 | PRO | 171 | PRO | 1.974 | 1.946 | 0.028 | 0.028 |
| 10 | TYR | 180 | PRO | 0.372 | 0.399 | -0.028 | 0.028 |
| 264 | CYS | 291 | PRO | 0.007 | 0.034 | -0.027 | 0.027 |
| 214 | ILE | 215 | PRO | 1.501 | 1.476 | 0.025 | 0.025 |
| 339 | LYS | 343 | SER | 0.000 | 0.025 | -0.025 | 0.025 |
| 14 | SER | 20 | VAL | 1.092 | 1.066 | 0.025 | 0.025 |
| 311 | LYS | 314 | ARG | 0.642 | 0.617 | 0.025 | 0.025 |
| 9 | PHE | 11 | VAL | 1.059 | 1.083 | -0.024 | 0.024 |
| 63 | VAL | 64 | GLN | 0.024 | 0.000 | 0.024 | 0.024 |
| 213 | THR | 217 | ILE | 0.690 | 0.666 | 0.024 | 0.024 |
| 318 | LEU | 328 | LEU | 1.570 | 1.547 | 0.024 | 0.024 |
| 48 | ILE | 95 | LEU | 1.002 | 1.026 | -0.023 | 0.023 |
| 128 | LEU | 223 | TYR | 0.134 | 0.157 | -0.023 | 0.023 |
| 176 | SER | 199 | ASN | 0.000 | 0.022 | -0.022 | 0.022 |
| 113 | GLU | 118 | THR | 0.021 | 0.000 | 0.021 | 0.021 |
| 28 | GLN | 37 | PHE | 3.215 | 3.235 | -0.020 | 0.020 |
| 57 | LEU | 321 | ILE | 1.148 | 1.128 | 0.020 | 0.020 |
| 180 | PRO | 186 | SER | 2.631 | 2.649 | -0.018 | 0.018 |
| 228 | PHE | 229 | THR | 0.000 | 0.018 | -0.018 | 0.018 |
| 47 | LEU | 87 | VAL | 0.016 | 0.000 | 0.016 | 0.016 |
| 202 | SER | 203 | PHE | 0.000 | 0.014 | -0.014 | 0.014 |
| 285 | PRO | 286 | ILE | 0.000 | 0.014 | -0.014 | 0.014 |
| 260 | ALA | 305 | ILE | 0.857 | 0.843 | 0.014 | 0.014 |
| 266 | VAL | 267 | PRO | 0.962 | 0.974 | -0.012 | 0.012 |
| 114 | GLY | 188 | GLY | 0.000 | 0.011 | -0.011 | 0.011 |
| 310 | ASN | 313 | PHE | 2.139 | 2.149 | -0.010 | 0.010 |
| 319 | THR | 325 | LYS | 1.346 | 1.336 | 0.010 | 0.010 |
| 180 | PRO | 184 | GLN | 1.874 | 1.865 | 0.009 | 0.009 |
| 72 | LEU | 73 | ASN | 0.000 | 0.009 | -0.009 | 0.009 |
| 226 | LEU | 251 | THR | 0.000 | 0.009 | -0.009 | 0.009 |
| 110 | CYS | 115 | PHE | 0.032 | 0.038 | -0.007 | 0.007 |
| 198 | VAL | 200 | ASN | 2.254 | 2.248 | 0.006 | 0.006 |
| 41 | ALA | 95 | LEU | 2.625 | 2.620 | 0.005 | 0.005 |
| 250 | VAL | 254 | VAL | 0.155 | 0.159 | -0.004 | 0.004 |
| 52 | PHE | 53 | PRO | 1.666 | 1.669 | -0.004 | 0.004 |
| 141 | LYS | 142 | PRO | 0.096 | 0.092 | 0.003 | 0.003 |
| 179 | ILE | 186 | SER | 0.323 | 0.320 | 0.003 | 0.003 |
| 111 | ASN | 172 | LEU | 2.688 | 2.690 | -0.003 | 0.003 |
| 11 | VAL | 20 | VAL | 1.299 | 1.302 | -0.002 | 0.002 |
| 131 | LEU | 223 | TYR | 0.704 | 0.705 | -0.001 | 0.001 |
RRCS change distribution
0.04
Mean ΔRRCS
1.68
Std Dev
0.05
Median
Magnitude classification
19
High (|Δ| ≥ 5.0)
100
Medium (2.3 ≤ |Δ| < 5.0)
809
Low (|Δ| < 2.3)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) were calculated for each conformational state based on inter-atomic distances. Changes (ΔRRCS) were computed by comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022).
Significance threshold. |ΔRRCS| ≥ 2.35, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Significant structural rearrangement.
Residues with large RRCS changes are critical for protein function. Mutations at these positions may disrupt the protein's ability to change shape properly.
Pathogenicity predictions
AlphaMissense predicts whether a mutation harms protein function:
- Pathogenic (score ≥ 0.564): mutation likely damages function.
- Ambiguous (0.34–0.563): effect uncertain.
- Benign (< 0.34): mutation likely tolerated.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). High conservation suggests the position is critical for function.
Allele frequency. How often a variant appears in the population. Rare variants (low frequency) may be more likely to be harmful.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar