PAR2
776
Total Contact Pairs
77
Above-threshold changes
12.88
Max Increase
-11.21
Max Decrease
Interactive snake plot
GPCRdb-style topology. Use the view buttons to recolor residues by data layer. Toggle contact links to overlay above-threshold residue-residue contacts. Click ICL or ECL labels to expand or collapse loop regions.
Red: stronger in active. Blue: stronger in inactive.
|ΔRRCS|
0.00
–
0.00
Largest active-inactive contact-score changes
Residue pairs ranked by |ΔRRCS| between the active and inactive models. GPCRdb generic numbers are shown in parentheses when available. Highlighted rows exceed the receptor-specific ΔRRCS threshold.
| Rank | Residue 1 | Residue 2 | Active RRCS | Inactive RRCS | ΔRRCS | Magnitude |
|---|---|---|---|---|---|---|
| 1 | ARG36 | GLN319 | 12.881 | 0.000 | +12.881 | HIGH |
| 2 | VAL236 (5.32x33) | TYR311 (6.59x59) | 0.065 | 11.274 | -11.209 | HIGH |
| 3 | PHE243 (5.39x40) | TYR311 (6.59x59) | 11.159 | 0.027 | +11.132 | HIGH |
| 4 | TYR345 (7.54x54) | ARG352 (8.51x51) | 0.000 | 9.822 | -9.822 | HIGH |
| 5 | TYR296 (6.44x45) | PHE300 (6.48x48) | 0.727 | 10.000 | -9.274 | HIGH |
| 6 | PHE128 (2.57x57) | THR334 (7.43x42) | 2.793 | 11.273 | -8.480 | HIGH |
| 7 | ARG36 | ASP62 | 7.200 | 0.000 | +7.200 | HIGH |
| 8 | LEU307 (6.55x55) | TYR326 (7.35x34) | 7.097 | 0.000 | +7.097 | HIGH |
| 9 | HIS310 (6.58x58) | SER320 | 7.080 | 0.000 | +7.080 | HIGH |
| 10 | TYR82 (1.39x39) | PRO129 (2.58x58) | 0.000 | 7.058 | -7.058 | HIGH |
| 11 | MET114 (2.43x43) | TYR345 (7.54x54) | 6.792 | 0.000 | +6.792 | HIGH |
| 12 | PHE300 (6.48x48) | SER333 (7.42x41) | 2.526 | 9.139 | -6.613 | HIGH |
| 13 | ARG103 (1.60x60) | ALA358 (8.57x57) | 6.604 | 0.000 | +6.604 | HIGH |
| 14 | LYS41 | SER60 | 0.903 | 7.127 | -6.224 | HIGH |
| 15 | SER37 | GLN319 | 6.178 | 0.000 | +6.178 | HIGH |
| 16 | ILE163 (3.40x40) | PHE300 (6.48x48) | 5.786 | 0.000 | +5.786 | HIGH |
| 17 | LEU130 (2.59x59) | TYR143 (23.52x52) | 5.994 | 0.209 | +5.785 | HIGH |
| 18 | ALA255 (5.51x51) | TYR296 (6.44x45) | 5.780 | 0.000 | +5.780 | HIGH |
| 19 | PRO341 (7.50x50) | PHE346 (7.55x55) | 5.775 | 0.000 | +5.775 | HIGH |
| 20 | TYR344 (7.53x53) | PHE351 (8.50x50) | 0.000 | 5.672 | -5.672 | HIGH |
| 21 | HIS135 (2.64x64) | TYR323 (7.32x31) | 0.000 | 5.575 | -5.575 | HIGH |
| 22 | PHE100 (1.57x57) | MET114 (2.43x43) | 0.000 | 5.539 | -5.539 | HIGH |
| 23 | ARG103 (1.60x60) | ASN357 (8.56x56) | 5.425 | 0.000 | +5.425 | HIGH |
| 24 | TRP98 (1.55x55) | ARG103 (1.60x60) | 2.420 | 7.792 | -5.373 | HIGH |
| 25 | LEU313 (6.61x61) | GLN319 | 5.347 | 0.000 | +5.347 | HIGH |
| 26 | TYR296 (6.44x45) | ASN336 (7.45x45) | 0.000 | 5.031 | -5.031 | HIGH |
| 27 | MET159 (3.36x36) | PHE300 (6.48x48) | 0.665 | 5.658 | -4.993 | MED |
| 28 | LEU69 | ASN139 | 4.987 | 0.000 | +4.987 | MED |
| 29 | TYR134 (2.63x63) | ASN139 | 16.835 | 11.930 | +4.905 | MED |
| 30 | MET159 (3.36x36) | TYR296 (6.44x45) | 0.000 | 4.882 | -4.882 | MED |
| 31 | PHE128 (2.57x57) | ILE132 (2.61x61) | 0.161 | 4.885 | -4.724 | MED |
| 32 | TYR345 (7.54x54) | PHE351 (8.50x50) | 7.188 | 2.624 | +4.564 | MED |
| 33 | TYR82 (1.39x39) | PHE128 (2.57x57) | 5.007 | 0.491 | +4.516 | MED |
| 34 | GLY40 | PHE59 | 4.453 | 0.000 | +4.453 | MED |
| 35 | ASN336 (7.45x45) | ASP340 (7.49x49) | 4.746 | 0.377 | +4.369 | MED |
| 36 | LYS131 (2.60x60) | PHE155 (3.32x32) | 6.118 | 1.809 | +4.309 | MED |
| 37 | ILE163 (3.40x40) | TYR296 (6.44x45) | 2.174 | 6.464 | -4.290 | MED |
| 38 | PHE251 (5.47x47) | TYR296 (6.44x45) | 6.020 | 1.755 | +4.264 | MED |
| 39 | HIS310 (6.58x58) | TYR323 (7.32x31) | 4.190 | 0.000 | +4.190 | MED |
| 40 | THR225 | HIS227 (45.51x51) | 0.378 | 4.495 | -4.118 | MED |
| 41 | TYR156 (3.33x33) | LEU307 (6.55x55) | 0.000 | 4.002 | -4.002 | MED |
| 42 | MET166 (3.43x43) | TYR344 (7.53x53) | 4.491 | 0.505 | +3.986 | MED |
| 43 | PHE86 (1.43x43) | PRO129 (2.58x58) | 3.954 | 0.018 | +3.936 | MED |
| 44 | TRP127 (2.56x56) | PHE154 (3.31x31) | 6.240 | 10.154 | -3.914 | MED |
| 45 | THR258 (5.54x54) | LEU293 (6.41x42) | 0.000 | 3.873 | -3.873 | MED |
| 46 | SER37 | GLY318 | 3.798 | 0.000 | +3.798 | MED |
| 47 | TRP175 (3.52x52) | LYS187 (4.38x38) | 8.736 | 4.963 | +3.773 | MED |
| 48 | MET114 (2.43x43) | TYR344 (7.53x53) | 0.791 | 4.544 | -3.754 | MED |
| 49 | LYS131 (2.60x60) | LEU330 (7.39x38) | 0.000 | 3.738 | -3.738 | MED |
| 50 | VAL68 | THR74 (1.31x31) | 3.731 | 0.000 | +3.731 | MED |
| 51 | ARG173 (3.50x50) | TYR344 (7.53x53) | 3.728 | 0.000 | +3.728 | MED |
| 52 | CYS361 (8.60x60) | ARG365 | 0.000 | 3.631 | -3.631 | MED |
| 53 | TYR262 (5.58x58) | VAL292 (6.40x41) | 3.615 | 0.000 | +3.615 | MED |
| 54 | THR83 (1.40x40) | ILE132 (2.61x61) | 3.521 | 0.000 | +3.521 | MED |
| 55 | ALA96 (1.53x53) | TYR345 (7.54x54) | 3.505 | 0.000 | +3.505 | MED |
| 56 | ASP43 | SER60 | 0.935 | 4.307 | -3.372 | MED |
| 57 | ASN149 (3.26x26) | TYR210 (4.61x62) | 4.621 | 7.898 | -3.276 | MED |
| 58 | ALA118 (2.47x47) | TYR345 (7.54x54) | 3.216 | 0.000 | +3.216 | MED |
| 59 | LEU288 (6.36x37) | VAL347 (7.56x56) | 0.896 | 4.093 | -3.196 | MED |
| 60 | MET274 | ARG282 (6.30x31) | 0.799 | 3.978 | -3.178 | MED |
| 61 | LYS131 (2.60x60) | LEU151 (3.28x28) | 0.931 | 4.101 | -3.170 | MED |
| 62 | LYS213 | ASP228 (45.52x52) | 6.415 | 9.574 | -3.159 | MED |
| 63 | HIS183 (34.53x53) | LYS187 (4.38x38) | 0.000 | 3.126 | -3.126 | MED |
| 64 | LEU269 (5.65x65) | ARG282 (6.30x31) | 4.627 | 1.516 | +3.111 | MED |
| 65 | ASP121 (2.50x50) | SER162 (3.39x39) | 3.881 | 0.771 | +3.110 | MED |
| 66 | GLU276 (6.24x25) | LYS280 (6.28x29) | 2.251 | 5.293 | -3.041 | MED |
| 67 | VAL99 | PHE351 (8.50x50) | 5.084 | 2.098 | +2.985 | MED |
| 68 | HIS135 (2.64x64) | ASN139 | 3.083 | 0.136 | +2.947 | MED |
| 69 | ARG173 (3.50x50) | LEU288 (6.36x37) | 2.904 | 0.000 | +2.904 | MED |
| 70 | LEU78 | HIS135 (2.64x64) | 2.939 | 0.042 | +2.897 | MED |
| 71 | TYR156 (3.33x33) | TYR326 (7.35x34) | 3.456 | 0.631 | +2.825 | MED |
| 72 | PHE100 (1.57x57) | ALA115 | 5.116 | 2.293 | +2.823 | MED |
| 73 | TYR82 (1.39x39) | ILE132 (2.61x61) | 3.107 | 0.356 | +2.752 | MED |
| 74 | VAL292 (6.40x41) | ASP340 (7.49x49) | 0.000 | 2.721 | -2.721 | MED |
| 75 | MET274 | GLU279 | 0.162 | 2.802 | -2.640 | MED |
| 76 | TYR134 (2.63x63) | ASN140 | 4.405 | 1.773 | +2.632 | MED |
| 77 | GLU279 | ARG282 (6.30x31) | 2.619 | 0.000 | +2.619 | MED |
| 78 | THR395 | SER396 | 0.000 | 2.562 | -2.562 | LOW |
| 79 | PHE100 (1.57x57) | THR104 | 2.594 | 0.034 | +2.561 | LOW |
| 80 | LEU78 | TYR82 (1.39x39) | 2.554 | 0.000 | +2.554 | LOW |
| 81 | MET159 (3.36x36) | ASN304 | 0.000 | 2.547 | -2.547 | LOW |
| 82 | TYR134 (2.63x63) | HIS135 (2.64x64) | 3.331 | 0.794 | +2.537 | LOW |
| 83 | ILE314 | GLN319 | 2.503 | 0.000 | +2.503 | LOW |
| 84 | TYR156 (3.33x33) | LEU330 (7.39x38) | 2.560 | 0.063 | +2.497 | LOW |
| 85 | SER3 | SER5 | 0.000 | 2.485 | -2.485 | LOW |
| 86 | LEU288 (6.36x37) | TYR344 (7.53x53) | 0.000 | 2.459 | -2.459 | LOW |
| 87 | VAL85 | PHE128 (2.57x57) | 2.842 | 0.389 | +2.453 | LOW |
| 88 | TYR134 (2.63x63) | THR225 | 2.448 | 0.000 | +2.448 | LOW |
| 89 | TYR160 | LEU246 | 0.932 | 3.379 | -2.447 | LOW |
| 90 | VAL61 | ILE218 | 2.425 | 0.000 | +2.425 | LOW |
| 91 | SER32 | SER33 | 0.000 | 2.413 | -2.413 | LOW |
| 92 | PHE86 (1.43x43) | VAL125 | 3.245 | 0.834 | +2.411 | LOW |
| 93 | TYR82 (1.39x39) | PHE86 (1.43x43) | 0.000 | 2.399 | -2.399 | LOW |
| 94 | TRP127 (2.56x56) | LEU151 (3.28x28) | 2.718 | 0.344 | +2.374 | LOW |
| 95 | CYS299 | LEU332 | 5.738 | 3.366 | +2.372 | LOW |
| 96 | TYR160 | VAL250 | 3.664 | 6.032 | -2.368 | LOW |
| 97 | ILE152 | LYS213 | 4.192 | 1.841 | +2.351 | LOW |
| 98 | THR74 (1.31x31) | ILE136 | 0.000 | 2.331 | -2.331 | LOW |
| 99 | HIS108 | HIS183 (34.53x53) | 4.133 | 1.834 | +2.299 | LOW |
| 100 | MET95 | PHE346 (7.55x55) | 2.290 | 0.000 | +2.290 | LOW |
Transmembrane domain analysis
Residues are grouped by segment according to whether their contact pairs are stronger in the active model (positive ΔRRCS) or the inactive model (negative ΔRRCS). Only residues linked to contact-pair changes above the receptor-specific ΔRRCS threshold (|ΔRRCS| ≥ 2.60, computed as max(mean(|Δ|) + σ, 0.2)) are shown.
| Segment | Range | Active-favoring residues | Count | Inactive-favoring residues | Count |
|---|---|---|---|---|---|
| TM1 | 74-103 | 103 (+8.7+6.6), 74 (+8.7+3.7), 86 (+5.2+3.9), 82 (+5.2-7.1), 83 (+2.8+3.5), 96 (+1.2+3.5) | 6 | 98 (-3.1-5.4), 100 (-2.1-5.5) | 2 |
| TM2 | 114-135 | 134 (+11.5+4.9), 135 (+9.2-5.6), 121 (+6.8+3.1), 130 (+6.0+5.8), 118 (+3.9+3.2), 132 (+0.9-4.7) | 6 | 128 (-3.7-8.5), 129 (-3.4-7.1), 127 (-3.4-3.9), 131 (-1.9+4.3), 114 (-1.5+6.8) | 5 |
| TM3 | 149-175 | 173 (+5.0+3.7), 155 (+4.6+4.3), 166 (+4.5+4.0), 175 (+3.2+3.8), 162 (+3.2+3.1), 156 (+2.7-4.0) | 6 | 159 (-13.0-5.0), 154 (-4.2-3.9), 149 (-3.5-3.3), 151 (-2.8-3.2), 163 (-0.5+5.8) | 5 |
| TM4 | 187-210 | 187 (+2.8+3.8) | 1 | 210 (-9.4-3.3) | 1 |
| TM5 | 236-269 | 243 (+14.0+11.1), 251 (+7.2+4.3), 255 (+3.8+5.8), 262 (+1.8+3.6), 269 (+0.4+3.1) | 5 | 258 (-7.2-3.9), 236 (-5.5-11.2) | 2 |
| TM6 | 276-313 | 310 (+12.4+7.1), 313 (+8.1+5.3), 307 (+4.6+7.1), 282 (+3.9-3.2), 292 (+1.6+3.6), 311 (+0.4-11.2) | 6 | 296 (-11.2-9.3), 300 (-9.9-9.3), 293 (-5.4-3.9), 288 (-4.1-3.2), 280 (-3.2-3.0), 276 (-3.2-3.0) | 6 |
| TM7 | 323-347 | 326 (+13.5+7.1), 345 (+10.0-9.8), 346 (+9.6+5.8), 340 (+8.7+4.4), 341 (+2.9+5.8), 336 (+2.4-5.0) | 6 | 334 (-5.5-8.5), 333 (-4.7-6.6), 347 (-2.8-3.2), 323 (-2.2-5.6), 330 (-2.1-3.7), 344 (-1.3-5.7) | 6 |
Interactive visualizations
ΔRRCS distribution
Active vs inactive comparison
Residue-wise changes
TM domain breakdown
Contact-site missense variants
105 gnomAD missense variants located at contact-forming residues, sorted by the ΔRRCS magnitude of the corresponding position.
| Position | Protein change | DNA change | Allele freq | Het count | ΔRRCS | AM score | Pathogenicity | Conservation | dbSNP |
|---|---|---|---|---|---|---|---|---|---|
| 319 | p.Gln319His | c.957G>C | 9.58e-06 | 14 | 12.88 | 0.129 | BENIGN | 0.37 | rs1186516213 |
| 236 | p.Val236Leu | c.706G>C | 6.22e-05 | 91 | 11.21 | 0.169 | BENIGN | 0.41 | rs375707707 |
| 236 | p.Val236Met | c.706G>A | 2.74e-06 | 4 | 11.21 | - | - | - | rs375707707 |
| 236 | p.Val236Ala | c.707T>C | 6.84e-07 | 1 | 11.21 | - | - | - | - |
| 243 | p.Phe243Ser | c.728T>C | 6.84e-07 | 1 | 11.13 | 0.895 | PATHOGENIC | 0.84 | - |
| 345 | p.Tyr345Asn | c.1033T>A | 6.84e-07 | 1 | 9.82 | 0.748 | PATHOGENIC | 0.97 | - |
| 352 | p.Arg352Lys | c.1055G>A | 1.03e-05 | 15 | 9.82 | 0.186 | BENIGN | 0.87 | rs765152103 |
| 345 | p.Tyr345His | c.1033T>C | 4.45e-05 | 65 | 9.82 | - | - | - | rs766276267 |
| 352 | p.Arg352Ser | c.1056G>C | 6.84e-07 | 1 | 9.82 | - | - | - | rs1378304707 |
| 300 | p.Phe300Leu | c.898T>C | 2.74e-06 | 4 | 9.27 | 0.995 | PATHOGENIC | 0.93 | rs1233110593 |
| 296 | p.Tyr296His | c.886T>C | 6.84e-07 | 1 | 9.27 | 0.830 | PATHOGENIC | 0.81 | rs1750394394 |
| 128 | p.Phe128Ile | c.382T>A | 1.37e-06 | 2 | 8.48 | 0.253 | BENIGN | 0.62 | - |
| 334 | p.Thr334Ala | c.1000A>G | 6.84e-07 | 1 | 8.48 | 0.113 | BENIGN | 0.61 | rs1278446886 |
| 334 | p.Thr334Ile | c.1001C>T | 2.05e-06 | 3 | 8.48 | - | - | - | - |
| 326 | p.Tyr326His | c.976T>C | 6.84e-07 | 1 | 7.10 | 0.849 | PATHOGENIC | 0.99 | rs1359132042 |
| 326 | p.Tyr326Cys | c.977A>G | 6.84e-07 | 1 | 7.10 | - | - | - | - |
| 310 | p.His310Pro | c.929A>C | 1.37e-06 | 2 | 7.08 | 0.904 | PATHOGENIC | 0.92 | rs754875227 |
| 320 | p.Ser320Asn | c.959G>A | 1.37e-06 | 2 | 7.08 | 0.340 | AMBIGUOUS | 0.55 | rs1486445755 |
| 310 | p.His310Arg | c.929A>G | 8.89e-06 | 13 | 7.08 | - | - | - | rs754875227 |
| 129 | p.Pro129Arg | c.386C>G | 6.84e-07 | 1 | 7.06 | 0.964 | PATHOGENIC | 0.98 | - |
| 82 | p.Tyr82Cys | c.245A>G | 2.74e-06 | 4 | 7.06 | 0.308 | BENIGN | 1.00 | rs1402378873 |
| 114 | p.Met114Val | c.340A>G | 1.37e-06 | 2 | 6.79 | 0.436 | AMBIGUOUS | 0.86 | rs1393875630 |
| 114 | p.Met114Leu | c.340A>T | 6.84e-07 | 1 | 6.79 | - | - | - | - |
| 333 | p.Ser333Cys | c.998C>G | 6.58e-06 | 1 | 6.61 | 0.334 | BENIGN | 0.68 | rs1750398347 |
| 333 | p.Ser333Phe | c.998C>T | 6.84e-07 | 1 | 6.61 | - | - | - | - |
| 358 | p.Ala358Ser | c.1072G>T | 6.84e-07 | 1 | 6.60 | 0.123 | BENIGN | 0.56 | - |
| 103 | p.Arg103Gln | c.308G>A | 3.97e-05 | 58 | 6.60 | 0.118 | BENIGN | 0.84 | rs185549069 |
| 103 | p.Arg103Pro | c.308G>C | 1.37e-06 | 2 | 6.60 | - | - | - | rs185549069 |
| 358 | p.Ala358Thr | c.1072G>A | 2.67e-05 | 39 | 6.60 | - | - | - | rs563654389 |
| 60 | p.Ser60Tyr | c.179C>A | 6.84e-07 | 1 | 6.22 | 0.098 | BENIGN | 0.41 | - |
| 60 | p.Ser60Phe | c.179C>T | 6.84e-07 | 1 | 6.22 | - | - | - | - |
| 37 | p.Ser37Asn | c.110G>A | 2.05e-06 | 3 | 6.18 | 0.490 | AMBIGUOUS | 0.77 | - |
| 130 | p.Leu130Trp | c.389T>G | 1.37e-06 | 2 | 5.79 | 0.426 | AMBIGUOUS | 0.74 | rs910420444 |
| 341 | p.Pro341Arg | c.1022C>G | 1.64e-05 | 24 | 5.78 | 0.959 | PATHOGENIC | 0.99 | rs764534865 |
| 346 | p.Phe346Ile | c.1036T>A | 6.84e-07 | 1 | 5.78 | 0.452 | AMBIGUOUS | 0.82 | rs767669676 |
| 135 | p.His135Arg | c.404A>G | 6.84e-06 | 10 | 5.58 | 0.820 | PATHOGENIC | 0.90 | rs148584357 |
| 323 | p.Tyr323Asn | c.967T>A | 6.84e-07 | 1 | 5.58 | 0.747 | PATHOGENIC | 0.99 | rs771965396 |
| 323 | p.Tyr323Cys | c.968A>G | 6.84e-07 | 1 | 5.58 | - | - | - | rs1220668965 |
| 357 | p.Asn357Asp | c.1069A>G | 2.74e-06 | 4 | 5.42 | 0.188 | BENIGN | 0.68 | rs1750400755 |
| 98 | p.Trp98Arg | c.292T>C | 1.03e-05 | 15 | 5.37 | 0.894 | PATHOGENIC | 0.75 | rs1003568019 |
| 98 | p.Trp98Gly | c.292T>G | 2.05e-06 | 3 | 5.37 | - | - | - | rs1003568019 |
| 313 | p.Leu313Val | c.937C>G | 1.32e-05 | 2 | 5.35 | 0.140 | BENIGN | 0.53 | rs905528105 |
| 313 | p.Leu313Gln | c.938T>A | 6.84e-07 | 1 | 5.35 | - | - | - | - |
| 313 | p.Leu313Pro | c.938T>C | 6.84e-07 | 1 | 5.35 | - | - | - | - |
| 159 | p.Met159Val | c.475A>G | 4.79e-06 | 7 | 4.99 | 0.498 | AMBIGUOUS | 0.96 | rs762545643 |
| 159 | p.Met159Thr | c.476T>C | 6.84e-07 | 1 | 4.99 | - | - | - | - |
| 159 | p.Met159Ile | c.477G>T | 1.18e-04 | 170 | 4.99 | - | - | - | rs115885685 |
| 159 | p.Met159Ile | c.477G>A | 1.06e-03 | 1551 | 4.99 | - | - | - | rs115885685 |
| 69 | p.Leu69Ile | c.205C>A | 1.37e-06 | 2 | 4.99 | 0.284 | BENIGN | 0.95 | rs147135859 |
| 69 | p.Leu69Arg | c.206T>G | 6.57e-06 | 1 | 4.99 | - | - | - | rs1471895947 |
| 69 | p.Leu69Pro | c.206T>C | 6.84e-07 | 1 | 4.99 | - | - | - | - |
| 134 | p.Tyr134Cys | c.401A>G | 9.58e-06 | 14 | 4.91 | 0.861 | PATHOGENIC | 0.99 | rs762020675 |
| 134 | p.Tyr134Phe | c.401A>T | 6.84e-07 | 1 | 4.91 | - | - | - | - |
| 40 | p.Gly40Asp | c.119G>A | 8.90e-06 | 13 | 4.45 | 0.720 | PATHOGENIC | 0.71 | rs143373085 |
| 340 | p.Asp340Asn | c.1018G>A | 2.74e-06 | 4 | 4.37 | 0.849 | PATHOGENIC | 0.99 | rs1176513304 |
| 340 | p.Asp340Glu | c.1020C>A | 6.84e-07 | 1 | 4.37 | - | - | - | rs763346141 |
| 155 | p.Phe155Val | c.463T>G | 6.84e-07 | 1 | 4.31 | 0.672 | PATHOGENIC | 0.96 | - |
| 155 | p.Phe155Leu | c.465C>G | 6.84e-07 | 1 | 4.31 | - | - | - | rs1186871864 |
| 227 | p.His227Arg | c.680A>G | 2.05e-06 | 3 | 4.12 | 0.801 | PATHOGENIC | 0.84 | - |
| 225 | p.Thr225Ile | c.674C>T | 6.59e-06 | 1 | 4.12 | 0.764 | PATHOGENIC | 0.94 | rs371819764 |
| 156 | p.Tyr156Cys | c.467A>G | 6.84e-07 | 1 | 4.00 | 0.650 | PATHOGENIC | 0.93 | rs1475152609 |
| 156 | p.Tyr156Phe | c.467A>T | 1.37e-06 | 2 | 4.00 | - | - | - | - |
| 166 | p.Met166Leu | c.496A>T | 6.84e-07 | 1 | 3.99 | 0.199 | BENIGN | 0.68 | - |
| 166 | p.Met166Val | c.496A>G | 6.84e-07 | 1 | 3.99 | - | - | - | rs1750381162 |
| 166 | p.Met166Ile | c.498G>T | 6.84e-07 | 1 | 3.99 | - | - | - | rs1052875957 |
| 166 | p.Met166Ile | c.498G>A | 6.84e-07 | 1 | 3.99 | - | - | - | rs1052875957 |
| 154 | p.Phe154Val | c.460T>G | 2.05e-06 | 3 | 3.91 | 0.368 | AMBIGUOUS | 0.63 | rs1226839415 |
| 293 | p.Leu293Pro | c.878T>C | 1.37e-06 | 2 | 3.87 | 0.890 | PATHOGENIC | 0.95 | rs1454241071 |
| 258 | p.Thr258Ala | c.772A>G | 3.42e-06 | 5 | 3.87 | 0.271 | BENIGN | 0.58 | - |
| 258 | p.Thr258Ile | c.773C>T | 6.84e-07 | 1 | 3.87 | - | - | - | rs1750389066 |
| 318 | p.Gly318Ser | c.952G>A | 6.60e-06 | 1 | 3.80 | 0.090 | BENIGN | 0.36 | rs1360640710 |
| 318 | p.Gly318Asp | c.953G>A | 6.84e-07 | 1 | 3.80 | - | - | - | rs755911067 |
| 175 | p.Trp175Arg | c.523T>C | 2.05e-06 | 3 | 3.77 | 0.355 | AMBIGUOUS | 0.57 | rs1159550519 |
| 187 | p.Lys187Asn | c.561G>C | 5.47e-06 | 8 | 3.77 | 0.140 | BENIGN | 0.47 | rs1011311806 |
| 330 | p.Leu330Phe | c.988C>T | 6.84e-07 | 1 | 3.74 | 0.678 | PATHOGENIC | 0.92 | rs1750397962 |
| 74 | p.Thr74Ala | c.220A>G | 6.84e-07 | 1 | 3.73 | 0.263 | BENIGN | 0.74 | rs781567981 |
| 68 | p.Val68Ile | c.202G>A | 5.47e-06 | 8 | 3.73 | 0.059 | BENIGN | 0.49 | rs757902001 |
| 74 | p.Thr74Asn | c.221C>A | 2.05e-06 | 3 | 3.73 | - | - | - | rs746271767 |
| 74 | p.Thr74Ile | c.221C>T | 6.84e-07 | 1 | 3.73 | - | - | - | - |
| 173 | p.Arg173Lys | c.518G>A | 6.84e-07 | 1 | 3.73 | 0.590 | PATHOGENIC | 0.97 | - |
| 365 | p.Arg365Cys | c.1093C>T | 1.03e-05 | 15 | 3.63 | 0.187 | BENIGN | 0.70 | rs1416971894 |
| 365 | p.Arg365Leu | c.1094G>T | 3.42e-06 | 5 | 3.63 | - | - | - | rs149001132 |
| 365 | p.Arg365His | c.1094G>A | 1.92e-05 | 28 | 3.63 | - | - | - | rs149001132 |
| 262 | p.Tyr262Cys | c.785A>G | 2.05e-06 | 3 | 3.62 | 0.333 | BENIGN | 0.97 | rs181651370 |
| 292 | p.Val292Ile | c.874G>A | 6.84e-07 | 1 | 3.62 | 0.140 | BENIGN | 0.96 | rs1340682362 |
| 292 | p.Val292Gly | c.875T>G | 6.84e-07 | 1 | 3.62 | - | - | - | - |
| 96 | p.Ala96Ser | c.286G>T | 6.84e-07 | 1 | 3.50 | 0.291 | BENIGN | 0.85 | - |
| 96 | p.Ala96Val | c.287C>T | 6.84e-07 | 1 | 3.50 | - | - | - | - |
| 43 | p.Asp43Val | c.128A>T | 1.37e-06 | 2 | 3.37 | 0.089 | BENIGN | 0.39 | - |
| 118 | p.Ala118Thr | c.352G>A | 6.84e-07 | 1 | 3.22 | 0.523 | AMBIGUOUS | 0.86 | rs1449513991 |
| 288 | p.Leu288Phe | c.862C>T | 9.58e-06 | 14 | 3.20 | 0.447 | AMBIGUOUS | 0.78 | rs765886275 |
| 282 | p.Arg282Met | c.845G>T | 4.10e-06 | 6 | 3.18 | 0.319 | BENIGN | 0.65 | rs187106934 |
| 274 | p.Met274Val | c.820A>G | 1.37e-06 | 2 | 3.18 | 0.054 | BENIGN | 0.33 | rs1215678275 |
| 274 | p.Met274Thr | c.821T>C | 1.37e-06 | 2 | 3.18 | - | - | - | rs1489493022 |
| 274 | p.Met274Ile | c.822G>A | 6.84e-07 | 1 | 3.18 | - | - | - | rs747974393 |
| 282 | p.Arg282Lys | c.845G>A | 7.52e-06 | 11 | 3.18 | - | - | - | rs187106934 |
| 151 | p.Leu151Arg | c.452T>G | 3.28e-05 | 5 | 3.17 | 0.769 | PATHOGENIC | 0.70 | rs1442301178 |
| 228 | p.Asp228His | c.682G>C | 6.84e-07 | 1 | 3.16 | 0.975 | PATHOGENIC | 0.95 | - |
| 213 | p.Lys213Glu | c.637A>G | 1.37e-06 | 2 | 3.16 | 0.115 | BENIGN | 0.52 | - |
| 183 | p.His183Pro | c.548A>C | 1.37e-06 | 2 | 3.13 | 0.087 | BENIGN | 0.47 | - |
| 269 | p.Leu269Pro | c.806T>C | 6.58e-06 | 1 | 3.11 | 0.874 | PATHOGENIC | 0.99 | rs1750390588 |
| 162 | p.Ser162Tyr | c.485C>A | 6.84e-07 | 1 | 3.11 | 0.978 | PATHOGENIC | 0.97 | - |
| 121 | p.Asp121Asn | c.361G>A | 2.05e-06 | 3 | 3.11 | 0.903 | PATHOGENIC | 1.00 | rs770126870 |
| 162 | p.Ser162Phe | c.485C>T | 6.84e-07 | 1 | 3.11 | - | - | - | rs1750380999 |
| 280 | p.Lys280Arg | c.839A>G | 6.84e-07 | 1 | 3.04 | 0.077 | BENIGN | 0.64 | rs1750392428 |
RRCS results
Top 1000 contact pairs ranked by |ΔRRCS|. Rows above the receptor-specific ΔRRCS threshold (|ΔRRCS| ≥ 2.60, computed as max(mean(|Δ|) + σ, 0.2)) are highlighted.
| Res1 | AA1 | Res2 | AA2 | Active RRCS | Inactive RRCS | ΔRRCS | |ΔRRCS| |
|---|---|---|---|---|---|---|---|
| 36 | ARG | 319 | GLN | 12.881 | 0.000 | 12.881 | 12.881 |
| 236 | VAL | 311 | TYR | 0.065 | 11.274 | -11.209 | 11.209 |
| 243 | PHE | 311 | TYR | 11.159 | 0.027 | 11.132 | 11.132 |
| 345 | TYR | 352 | ARG | 0.000 | 9.822 | -9.822 | 9.822 |
| 296 | TYR | 300 | PHE | 0.727 | 10.000 | -9.274 | 9.274 |
| 128 | PHE | 334 | THR | 2.793 | 11.273 | -8.480 | 8.480 |
| 36 | ARG | 62 | ASP | 7.200 | 0.000 | 7.200 | 7.200 |
| 307 | LEU | 326 | TYR | 7.097 | 0.000 | 7.097 | 7.097 |
| 310 | HIS | 320 | SER | 7.080 | 0.000 | 7.080 | 7.080 |
| 82 | TYR | 129 | PRO | 0.000 | 7.058 | -7.058 | 7.058 |
| 114 | MET | 345 | TYR | 6.792 | 0.000 | 6.792 | 6.792 |
| 300 | PHE | 333 | SER | 2.526 | 9.139 | -6.613 | 6.613 |
| 103 | ARG | 358 | ALA | 6.604 | 0.000 | 6.604 | 6.604 |
| 41 | LYS | 60 | SER | 0.903 | 7.127 | -6.224 | 6.224 |
| 37 | SER | 319 | GLN | 6.178 | 0.000 | 6.178 | 6.178 |
| 163 | ILE | 300 | PHE | 5.786 | 0.000 | 5.786 | 5.786 |
| 130 | LEU | 143 | TYR | 5.994 | 0.209 | 5.785 | 5.785 |
| 255 | ALA | 296 | TYR | 5.780 | 0.000 | 5.780 | 5.780 |
| 341 | PRO | 346 | PHE | 5.775 | 0.000 | 5.775 | 5.775 |
| 344 | TYR | 351 | PHE | 0.000 | 5.672 | -5.672 | 5.672 |
| 135 | HIS | 323 | TYR | 0.000 | 5.575 | -5.575 | 5.575 |
| 100 | PHE | 114 | MET | 0.000 | 5.539 | -5.539 | 5.539 |
| 103 | ARG | 357 | ASN | 5.425 | 0.000 | 5.425 | 5.425 |
| 98 | TRP | 103 | ARG | 2.420 | 7.792 | -5.373 | 5.373 |
| 313 | LEU | 319 | GLN | 5.347 | 0.000 | 5.347 | 5.347 |
| 296 | TYR | 336 | ASN | 0.000 | 5.031 | -5.031 | 5.031 |
| 159 | MET | 300 | PHE | 0.665 | 5.658 | -4.993 | 4.993 |
| 69 | LEU | 139 | ASN | 4.987 | 0.000 | 4.987 | 4.987 |
| 134 | TYR | 139 | ASN | 16.835 | 11.930 | 4.905 | 4.905 |
| 159 | MET | 296 | TYR | 0.000 | 4.882 | -4.882 | 4.882 |
| 128 | PHE | 132 | ILE | 0.161 | 4.885 | -4.724 | 4.724 |
| 345 | TYR | 351 | PHE | 7.188 | 2.624 | 4.564 | 4.564 |
| 82 | TYR | 128 | PHE | 5.007 | 0.491 | 4.516 | 4.516 |
| 40 | GLY | 59 | PHE | 4.453 | 0.000 | 4.453 | 4.453 |
| 336 | ASN | 340 | ASP | 4.746 | 0.377 | 4.369 | 4.369 |
| 131 | LYS | 155 | PHE | 6.118 | 1.809 | 4.309 | 4.309 |
| 163 | ILE | 296 | TYR | 2.174 | 6.464 | -4.290 | 4.290 |
| 251 | PHE | 296 | TYR | 6.020 | 1.755 | 4.264 | 4.264 |
| 310 | HIS | 323 | TYR | 4.190 | 0.000 | 4.190 | 4.190 |
| 225 | THR | 227 | HIS | 0.378 | 4.495 | -4.118 | 4.118 |
| 156 | TYR | 307 | LEU | 0.000 | 4.002 | -4.002 | 4.002 |
| 166 | MET | 344 | TYR | 4.491 | 0.505 | 3.986 | 3.986 |
| 86 | PHE | 129 | PRO | 3.954 | 0.018 | 3.936 | 3.936 |
| 127 | TRP | 154 | PHE | 6.240 | 10.154 | -3.914 | 3.914 |
| 258 | THR | 293 | LEU | 0.000 | 3.873 | -3.873 | 3.873 |
| 37 | SER | 318 | GLY | 3.798 | 0.000 | 3.798 | 3.798 |
| 175 | TRP | 187 | LYS | 8.736 | 4.963 | 3.773 | 3.773 |
| 114 | MET | 344 | TYR | 0.791 | 4.544 | -3.754 | 3.754 |
| 131 | LYS | 330 | LEU | 0.000 | 3.738 | -3.738 | 3.738 |
| 68 | VAL | 74 | THR | 3.731 | 0.000 | 3.731 | 3.731 |
| 173 | ARG | 344 | TYR | 3.728 | 0.000 | 3.728 | 3.728 |
| 361 | CYS | 365 | ARG | 0.000 | 3.631 | -3.631 | 3.631 |
| 262 | TYR | 292 | VAL | 3.615 | 0.000 | 3.615 | 3.615 |
| 83 | THR | 132 | ILE | 3.521 | 0.000 | 3.521 | 3.521 |
| 96 | ALA | 345 | TYR | 3.505 | 0.000 | 3.505 | 3.505 |
| 43 | ASP | 60 | SER | 0.935 | 4.307 | -3.372 | 3.372 |
| 149 | ASN | 210 | TYR | 4.621 | 7.898 | -3.276 | 3.276 |
| 118 | ALA | 345 | TYR | 3.216 | 0.000 | 3.216 | 3.216 |
| 288 | LEU | 347 | VAL | 0.896 | 4.093 | -3.196 | 3.196 |
| 274 | MET | 282 | ARG | 0.799 | 3.978 | -3.178 | 3.178 |
| 131 | LYS | 151 | LEU | 0.931 | 4.101 | -3.170 | 3.170 |
| 213 | LYS | 228 | ASP | 6.415 | 9.574 | -3.159 | 3.159 |
| 183 | HIS | 187 | LYS | 0.000 | 3.126 | -3.126 | 3.126 |
| 269 | LEU | 282 | ARG | 4.627 | 1.516 | 3.111 | 3.111 |
| 121 | ASP | 162 | SER | 3.881 | 0.771 | 3.110 | 3.110 |
| 276 | GLU | 280 | LYS | 2.251 | 5.293 | -3.041 | 3.041 |
| 99 | VAL | 351 | PHE | 5.084 | 2.098 | 2.985 | 2.985 |
| 135 | HIS | 139 | ASN | 3.083 | 0.136 | 2.947 | 2.947 |
| 173 | ARG | 288 | LEU | 2.904 | 0.000 | 2.904 | 2.904 |
| 78 | LEU | 135 | HIS | 2.939 | 0.042 | 2.897 | 2.897 |
| 156 | TYR | 326 | TYR | 3.456 | 0.631 | 2.825 | 2.825 |
| 100 | PHE | 115 | ALA | 5.116 | 2.293 | 2.823 | 2.823 |
| 82 | TYR | 132 | ILE | 3.107 | 0.356 | 2.752 | 2.752 |
| 292 | VAL | 340 | ASP | 0.000 | 2.721 | -2.721 | 2.721 |
| 274 | MET | 279 | GLU | 0.162 | 2.802 | -2.640 | 2.640 |
| 134 | TYR | 140 | ASN | 4.405 | 1.773 | 2.632 | 2.632 |
| 279 | GLU | 282 | ARG | 2.619 | 0.000 | 2.619 | 2.619 |
| 395 | THR | 396 | SER | 0.000 | 2.562 | -2.562 | 2.562 |
| 100 | PHE | 104 | THR | 2.594 | 0.034 | 2.561 | 2.561 |
| 78 | LEU | 82 | TYR | 2.554 | 0.000 | 2.554 | 2.554 |
| 159 | MET | 304 | ASN | 0.000 | 2.547 | -2.547 | 2.547 |
| 134 | TYR | 135 | HIS | 3.331 | 0.794 | 2.537 | 2.537 |
| 314 | ILE | 319 | GLN | 2.503 | 0.000 | 2.503 | 2.503 |
| 156 | TYR | 330 | LEU | 2.560 | 0.063 | 2.497 | 2.497 |
| 3 | SER | 5 | SER | 0.000 | 2.485 | -2.485 | 2.485 |
| 288 | LEU | 344 | TYR | 0.000 | 2.459 | -2.459 | 2.459 |
| 85 | VAL | 128 | PHE | 2.842 | 0.389 | 2.453 | 2.453 |
| 134 | TYR | 225 | THR | 2.448 | 0.000 | 2.448 | 2.448 |
| 160 | TYR | 246 | LEU | 0.932 | 3.379 | -2.447 | 2.447 |
| 61 | VAL | 218 | ILE | 2.425 | 0.000 | 2.425 | 2.425 |
| 32 | SER | 33 | SER | 0.000 | 2.413 | -2.413 | 2.413 |
| 86 | PHE | 125 | VAL | 3.245 | 0.834 | 2.411 | 2.411 |
| 82 | TYR | 86 | PHE | 0.000 | 2.399 | -2.399 | 2.399 |
| 127 | TRP | 151 | LEU | 2.718 | 0.344 | 2.374 | 2.374 |
| 299 | CYS | 332 | LEU | 5.738 | 3.366 | 2.372 | 2.372 |
| 160 | TYR | 250 | VAL | 3.664 | 6.032 | -2.368 | 2.368 |
| 152 | ILE | 213 | LYS | 4.192 | 1.841 | 2.351 | 2.351 |
| 74 | THR | 136 | ILE | 0.000 | 2.331 | -2.331 | 2.331 |
| 108 | HIS | 183 | HIS | 4.133 | 1.834 | 2.299 | 2.299 |
| 95 | MET | 346 | PHE | 2.290 | 0.000 | 2.290 | 2.290 |
| 300 | PHE | 336 | ASN | 5.550 | 3.265 | 2.286 | 2.286 |
| 169 | LEU | 344 | TYR | 2.277 | 0.000 | 2.277 | 2.277 |
| 38 | LEU | 65 | SER | 3.383 | 1.160 | 2.223 | 2.223 |
| 182 | GLY | 187 | LYS | 6.833 | 4.630 | 2.202 | 2.202 |
| 169 | LEU | 289 | ILE | 0.000 | 2.195 | -2.195 | 2.195 |
| 242 | TYR | 243 | PHE | 2.610 | 0.420 | 2.190 | 2.190 |
| 262 | TYR | 290 | VAL | 0.000 | 2.183 | -2.183 | 2.183 |
| 266 | ILE | 270 | ARG | 2.174 | 0.000 | 2.174 | 2.174 |
| 166 | MET | 340 | ASP | 2.550 | 0.381 | 2.168 | 2.168 |
| 303 | SER | 326 | TYR | 2.167 | 0.000 | 2.167 | 2.167 |
| 174 | TYR | 264 | LEU | 3.688 | 1.574 | 2.114 | 2.114 |
| 95 | MET | 355 | ALA | 0.281 | 2.391 | -2.110 | 2.110 |
| 82 | TYR | 135 | HIS | 2.107 | 0.000 | 2.107 | 2.107 |
| 213 | LYS | 226 | CYS | 4.272 | 2.168 | 2.104 | 2.104 |
| 113 | TYR | 168 | CYS | 3.533 | 5.608 | -2.075 | 2.075 |
| 92 | SER | 341 | PRO | 3.968 | 6.028 | -2.060 | 2.060 |
| 213 | LYS | 227 | HIS | 6.555 | 4.497 | 2.058 | 2.058 |
| 74 | THR | 139 | ASN | 2.055 | 0.000 | 2.055 | 2.055 |
| 75 | THR | 135 | HIS | 2.042 | 0.000 | 2.042 | 2.042 |
| 240 | PHE | 315 | LYS | 2.025 | 0.000 | 2.025 | 2.025 |
| 254 | PRO | 296 | TYR | 2.022 | 0.000 | 2.022 | 2.022 |
| 206 | THR | 210 | TYR | 1.962 | 3.965 | -2.003 | 2.003 |
| 123 | LEU | 154 | PHE | 3.941 | 1.948 | 1.993 | 1.993 |
| 230 | LEU | 236 | VAL | 1.989 | 0.001 | 1.988 | 1.988 |
| 251 | PHE | 301 | THR | 5.059 | 3.105 | 1.954 | 1.954 |
| 240 | PHE | 311 | TYR | 2.803 | 4.751 | -1.948 | 1.948 |
| 69 | LEU | 74 | THR | 1.944 | 0.000 | 1.944 | 1.944 |
| 306 | LEU | 325 | LEU | 3.457 | 1.527 | 1.930 | 1.930 |
| 139 | ASN | 323 | TYR | 0.000 | 1.929 | -1.929 | 1.929 |
| 98 | TRP | 102 | PHE | 4.822 | 2.929 | 1.893 | 1.893 |
| 121 | ASP | 340 | ASP | 3.669 | 1.778 | 1.891 | 1.891 |
| 154 | PHE | 210 | TYR | 3.296 | 5.185 | -1.889 | 1.889 |
| 236 | VAL | 314 | ILE | 1.886 | 0.000 | 1.886 | 1.886 |
| 346 | PHE | 351 | PHE | 1.884 | 0.000 | 1.884 | 1.884 |
| 392 | THR | 393 | VAL | 2.184 | 0.303 | 1.882 | 1.882 |
| 93 | ASN | 122 | LEU | 1.626 | 3.500 | -1.874 | 1.874 |
| 161 | CYS | 202 | ILE | 3.022 | 1.162 | 1.859 | 1.859 |
| 161 | CYS | 199 | TRP | 3.232 | 5.083 | -1.850 | 1.850 |
| 251 | PHE | 300 | PHE | 4.108 | 2.259 | 1.849 | 1.849 |
| 74 | THR | 135 | HIS | 3.261 | 1.420 | 1.841 | 1.841 |
| 212 | VAL | 239 | MET | 2.413 | 0.580 | 1.833 | 1.833 |
| 390 | SER | 391 | THR | 0.424 | 2.246 | -1.821 | 1.821 |
| 342 | PHE | 346 | PHE | 2.474 | 0.662 | 1.812 | 1.812 |
| 236 | VAL | 315 | LYS | 1.798 | 0.000 | 1.798 | 1.798 |
| 159 | MET | 160 | TYR | 1.860 | 3.643 | -1.783 | 1.783 |
| 100 | PHE | 351 | PHE | 0.000 | 1.773 | -1.773 | 1.773 |
| 342 | PHE | 347 | VAL | 1.771 | 0.000 | 1.771 | 1.771 |
| 292 | VAL | 344 | TYR | 2.614 | 0.852 | 1.761 | 1.761 |
| 299 | CYS | 333 | SER | 5.577 | 3.826 | 1.751 | 1.751 |
| 295 | MET | 340 | ASP | 1.749 | 0.000 | 1.749 | 1.749 |
| 99 | VAL | 354 | HIS | 0.245 | 1.985 | -1.740 | 1.740 |
| 166 | MET | 336 | ASN | 1.733 | 0.000 | 1.733 | 1.733 |
| 130 | LEU | 151 | LEU | 0.591 | 2.306 | -1.715 | 1.715 |
| 48 | VAL | 49 | THR | 0.000 | 1.688 | -1.688 | 1.688 |
| 346 | PHE | 352 | ARG | 2.224 | 3.896 | -1.672 | 1.672 |
| 340 | ASP | 345 | TYR | 1.668 | 0.000 | 1.668 | 1.668 |
| 125 | VAL | 128 | PHE | 1.664 | 0.000 | 1.664 | 1.664 |
| 216 | ILE | 229 | VAL | 1.835 | 0.173 | 1.663 | 1.663 |
| 262 | TYR | 289 | ILE | 7.993 | 6.333 | 1.660 | 1.660 |
| 174 | TYR | 261 | ALA | 2.004 | 0.349 | 1.655 | 1.655 |
| 117 | LEU | 166 | MET | 0.943 | 2.595 | -1.652 | 1.652 |
| 82 | TYR | 131 | LYS | 1.648 | 0.000 | 1.648 | 1.648 |
| 141 | TRP | 226 | CYS | 2.893 | 1.248 | 1.645 | 1.645 |
| 113 | TYR | 169 | LEU | 2.344 | 0.725 | 1.619 | 1.619 |
| 306 | LEU | 322 | VAL | 1.615 | 0.000 | 1.615 | 1.615 |
| 93 | ASN | 118 | ALA | 2.925 | 1.320 | 1.605 | 1.605 |
| 141 | TRP | 148 | CYS | 6.231 | 7.826 | -1.595 | 1.595 |
| 150 | VAL | 210 | TYR | 2.673 | 4.261 | -1.588 | 1.588 |
| 340 | ASP | 344 | TYR | 2.158 | 3.737 | -1.579 | 1.579 |
| 59 | PHE | 219 | PRO | 1.576 | 0.000 | 1.576 | 1.576 |
| 307 | LEU | 311 | TYR | 1.572 | 0.000 | 1.572 | 1.572 |
| 313 | LEU | 318 | GLY | 1.567 | 0.000 | 1.567 | 1.567 |
| 113 | TYR | 165 | PHE | 1.694 | 3.248 | -1.553 | 1.553 |
| 134 | TYR | 226 | CYS | 1.444 | 2.997 | -1.553 | 1.553 |
| 251 | PHE | 304 | ASN | 7.028 | 5.479 | 1.549 | 1.549 |
| 79 | PRO | 135 | HIS | 1.501 | 0.000 | 1.501 | 1.501 |
| 78 | LEU | 132 | ILE | 0.000 | 1.488 | -1.488 | 1.488 |
| 214 | GLN | 229 | VAL | 3.846 | 5.331 | -1.485 | 1.485 |
| 288 | LEU | 343 | VAL | 1.328 | 2.800 | -1.472 | 1.472 |
| 167 | THR | 254 | PRO | 4.801 | 3.335 | 1.466 | 1.466 |
| 103 | ARG | 354 | HIS | 4.854 | 3.391 | 1.463 | 1.463 |
| 96 | ALA | 351 | PHE | 1.455 | 2.910 | -1.454 | 1.454 |
| 295 | MET | 339 | ILE | 1.907 | 0.465 | 1.442 | 1.442 |
| 161 | CYS | 165 | PHE | 0.498 | 1.920 | -1.422 | 1.422 |
| 97 | LEU | 115 | ALA | 0.532 | 1.948 | -1.416 | 1.416 |
| 230 | LEU | 234 | LEU | 0.000 | 1.391 | -1.391 | 1.391 |
| 79 | PRO | 132 | ILE | 1.368 | 0.000 | 1.368 | 1.368 |
| 166 | MET | 292 | VAL | 0.210 | 1.570 | -1.360 | 1.360 |
| 73 | LEU | 78 | LEU | 3.025 | 4.374 | -1.349 | 1.349 |
| 88 | VAL | 342 | PHE | 0.425 | 1.768 | -1.343 | 1.343 |
| 141 | TRP | 147 | LEU | 3.108 | 4.430 | -1.322 | 1.322 |
| 41 | LYS | 58 | VAL | 1.575 | 0.262 | 1.314 | 1.314 |
| 166 | MET | 258 | THR | 0.139 | 1.438 | -1.299 | 1.299 |
| 170 | SER | 265 | MET | 0.841 | 2.124 | -1.284 | 1.284 |
| 35 | GLY | 319 | GLN | 1.284 | 0.000 | 1.284 | 1.284 |
| 141 | TRP | 224 | THR | 4.856 | 6.113 | -1.257 | 1.257 |
| 117 | LEU | 340 | ASP | 2.638 | 1.385 | 1.253 | 1.253 |
| 152 | ILE | 156 | TYR | 2.599 | 1.355 | 1.244 | 1.244 |
| 274 | MET | 278 | SER | 2.579 | 1.338 | 1.241 | 1.241 |
| 166 | MET | 295 | MET | 1.230 | 0.000 | 1.230 | 1.230 |
| 88 | VAL | 338 | CYS | 1.340 | 0.112 | 1.228 | 1.228 |
| 393 | VAL | 394 | LYS | 1.225 | 0.000 | 1.225 | 1.225 |
| 116 | ASN | 165 | PHE | 7.651 | 8.867 | -1.216 | 1.216 |
| 140 | ASN | 223 | ILE | 3.644 | 4.846 | -1.202 | 1.202 |
| 100 | PHE | 344 | TYR | 0.000 | 1.198 | -1.198 | 1.198 |
| 212 | VAL | 228 | ASP | 3.266 | 4.435 | -1.169 | 1.169 |
| 320 | SER | 322 | VAL | 1.164 | 0.000 | 1.164 | 1.164 |
| 100 | PHE | 101 | LEU | 1.163 | 0.000 | 1.163 | 1.163 |
| 85 | VAL | 334 | THR | 2.414 | 1.251 | 1.163 | 1.163 |
| 127 | TRP | 150 | VAL | 0.056 | 1.218 | -1.162 | 1.162 |
| 349 | HIS | 353 | ASP | 4.653 | 5.814 | -1.161 | 1.161 |
| 319 | GLN | 322 | VAL | 0.000 | 1.142 | -1.142 | 1.142 |
| 176 | VAL | 183 | HIS | 1.920 | 3.057 | -1.138 | 1.138 |
| 145 | GLU | 214 | GLN | 1.169 | 0.034 | 1.136 | 1.136 |
| 173 | ARG | 265 | MET | 1.392 | 2.516 | -1.124 | 1.124 |
| 156 | TYR | 209 | LEU | 1.568 | 0.457 | 1.111 | 1.111 |
| 297 | LEU | 301 | THR | 1.211 | 0.103 | 1.108 | 1.108 |
| 217 | PHE | 223 | ILE | 3.711 | 2.619 | 1.092 | 1.092 |
| 113 | TYR | 172 | GLN | 1.347 | 0.256 | 1.090 | 1.090 |
| 69 | LEU | 321 | HIS | 0.000 | 1.089 | -1.089 | 1.089 |
| 326 | TYR | 330 | LEU | 6.820 | 5.740 | 1.080 | 1.080 |
| 208 | PRO | 242 | TYR | 4.772 | 5.851 | -1.078 | 1.078 |
| 148 | CYS | 213 | LYS | 1.014 | 2.068 | -1.054 | 1.054 |
| 85 | VAL | 125 | VAL | 0.647 | 1.693 | -1.046 | 1.046 |
| 130 | LEU | 141 | TRP | 1.579 | 0.541 | 1.038 | 1.038 |
| 43 | ASP | 58 | VAL | 1.695 | 0.658 | 1.036 | 1.036 |
| 138 | GLY | 223 | ILE | 1.036 | 0.000 | 1.036 | 1.036 |
| 90 | LEU | 122 | LEU | 1.307 | 2.342 | -1.034 | 1.034 |
| 104 | THR | 111 | VAL | 1.135 | 2.169 | -1.033 | 1.033 |
| 344 | TYR | 345 | TYR | 1.031 | 0.000 | 1.031 | 1.031 |
| 117 | LEU | 165 | PHE | 2.543 | 1.517 | 1.025 | 1.025 |
| 159 | MET | 333 | SER | 1.016 | 0.000 | 1.016 | 1.016 |
| 170 | SER | 258 | THR | 1.910 | 2.919 | -1.009 | 1.009 |
| 269 | LEU | 286 | ILE | 0.405 | 1.406 | -1.001 | 1.001 |
| 313 | LEU | 320 | SER | 0.996 | 0.000 | 0.996 | 0.996 |
| 240 | PHE | 312 | PHE | 4.727 | 3.736 | 0.991 | 0.991 |
| 230 | LEU | 239 | MET | 1.875 | 2.862 | -0.988 | 0.988 |
| 269 | LEU | 274 | MET | 0.000 | 0.980 | -0.980 | 0.980 |
| 163 | ILE | 255 | ALA | 0.000 | 0.977 | -0.977 | 0.977 |
| 128 | PHE | 155 | PHE | 0.977 | 0.000 | 0.977 | 0.977 |
| 306 | LEU | 326 | TYR | 2.302 | 1.331 | 0.971 | 0.971 |
| 167 | THR | 258 | THR | 2.875 | 3.844 | -0.969 | 0.969 |
| 97 | LEU | 101 | LEU | 0.938 | 1.900 | -0.961 | 0.961 |
| 110 | ALA | 172 | GLN | 1.129 | 0.169 | 0.961 | 0.961 |
| 282 | ARG | 286 | ILE | 0.955 | 0.000 | 0.955 | 0.955 |
| 216 | ILE | 225 | THR | 7.219 | 8.171 | -0.952 | 0.952 |
| 265 | MET | 289 | ILE | 0.943 | 0.000 | 0.943 | 0.943 |
| 352 | ARG | 356 | LYS | 0.820 | 1.752 | -0.932 | 0.932 |
| 131 | LYS | 326 | TYR | 0.000 | 0.923 | -0.923 | 0.923 |
| 165 | PHE | 195 | SER | 2.752 | 3.672 | -0.919 | 0.919 |
| 78 | LEU | 331 | CYS | 1.018 | 0.104 | 0.913 | 0.913 |
| 303 | SER | 304 | ASN | 0.907 | 0.000 | 0.907 | 0.907 |
| 14 | ILE | 77 | PHE | 0.907 | 0.000 | 0.907 | 0.907 |
| 90 | LEU | 126 | ILE | 0.241 | 1.147 | -0.906 | 0.906 |
| 255 | ALA | 297 | LEU | 0.000 | 0.905 | -0.905 | 0.905 |
| 206 | THR | 242 | TYR | 0.472 | 1.376 | -0.905 | 0.905 |
| 114 | MET | 169 | LEU | 2.237 | 1.336 | 0.901 | 0.901 |
| 251 | PHE | 297 | LEU | 0.000 | 0.900 | -0.900 | 0.900 |
| 149 | ASN | 213 | LYS | 4.757 | 5.654 | -0.898 | 0.898 |
| 153 | GLY | 209 | LEU | 0.638 | 1.532 | -0.894 | 0.894 |
| 391 | THR | 392 | THR | 1.853 | 2.747 | -0.894 | 0.894 |
| 117 | LEU | 121 | ASP | 1.629 | 0.739 | 0.891 | 0.891 |
| 70 | THR | 75 | THR | 0.889 | 0.000 | 0.889 | 0.889 |
| 61 | VAL | 321 | HIS | 0.000 | 0.887 | -0.887 | 0.887 |
| 303 | SER | 329 | ALA | 3.660 | 4.540 | -0.881 | 0.881 |
| 82 | TYR | 334 | THR | 0.875 | 0.000 | 0.875 | 0.875 |
| 243 | PHE | 246 | LEU | 1.116 | 0.245 | 0.871 | 0.871 |
| 155 | PHE | 334 | THR | 1.651 | 0.788 | 0.862 | 0.862 |
| 345 | TYR | 355 | ALA | 0.000 | 0.861 | -0.861 | 0.861 |
| 152 | ILE | 209 | LEU | 1.049 | 0.193 | 0.856 | 0.856 |
| 310 | HIS | 311 | TYR | 0.854 | 0.000 | 0.854 | 0.854 |
| 150 | VAL | 154 | PHE | 0.036 | 0.885 | -0.848 | 0.848 |
| 90 | LEU | 125 | VAL | 1.774 | 0.934 | 0.840 | 0.840 |
| 130 | LEU | 147 | LEU | 2.139 | 1.300 | 0.840 | 0.840 |
| 265 | MET | 286 | ILE | 0.000 | 0.835 | -0.835 | 0.835 |
| 284 | ARG | 347 | VAL | 0.000 | 0.834 | -0.834 | 0.834 |
| 107 | LYS | 188 | ALA | 1.827 | 0.992 | 0.834 | 0.834 |
| 313 | LEU | 317 | GLN | 0.830 | 0.000 | 0.830 | 0.830 |
| 348 | SER | 351 | PHE | 0.542 | 1.365 | -0.823 | 0.823 |
| 275 | ASP | 277 | ASN | 0.000 | 0.822 | -0.822 | 0.822 |
| 72 | LYS | 77 | PHE | 1.582 | 0.762 | 0.819 | 0.819 |
| 155 | PHE | 156 | TYR | 0.518 | 1.331 | -0.813 | 0.813 |
| 42 | VAL | 59 | PHE | 2.131 | 1.319 | 0.812 | 0.812 |
| 123 | LEU | 158 | ASN | 3.958 | 3.157 | 0.800 | 0.800 |
| 320 | SER | 321 | HIS | 0.000 | 0.786 | -0.786 | 0.786 |
| 121 | ASP | 337 | SER | 10.201 | 9.417 | 0.784 | 0.784 |
| 316 | SER | 317 | GLN | 0.784 | 0.000 | 0.784 | 0.784 |
| 42 | VAL | 58 | VAL | 1.021 | 0.238 | 0.783 | 0.783 |
| 66 | ALA | 221 | LEU | 0.783 | 0.000 | 0.783 | 0.783 |
| 237 | GLY | 315 | LYS | 0.769 | 0.000 | 0.769 | 0.769 |
| 319 | GLN | 321 | HIS | 0.765 | 0.000 | 0.765 | 0.765 |
| 343 | VAL | 344 | TYR | 0.749 | 0.000 | 0.749 | 0.749 |
| 345 | TYR | 356 | LYS | 0.000 | 0.749 | -0.749 | 0.749 |
| 139 | ASN | 223 | ILE | 1.473 | 0.724 | 0.749 | 0.749 |
| 41 | LYS | 59 | PHE | 2.077 | 1.340 | 0.737 | 0.737 |
| 297 | LEU | 302 | PRO | 0.781 | 0.046 | 0.735 | 0.735 |
| 140 | ASN | 224 | THR | 6.317 | 5.584 | 0.733 | 0.733 |
| 5 | SER | 8 | TRP | 0.724 | 0.000 | 0.724 | 0.724 |
| 299 | CYS | 336 | ASN | 2.706 | 3.426 | -0.720 | 0.720 |
| 97 | LEU | 118 | ALA | 0.230 | 0.948 | -0.718 | 0.718 |
| 124 | SER | 158 | ASN | 4.192 | 3.480 | 0.712 | 0.712 |
| 175 | TRP | 179 | ASN | 1.972 | 2.682 | -0.709 | 0.709 |
| 62 | ASP | 64 | PHE | 0.468 | 1.177 | -0.709 | 0.709 |
| 113 | TYR | 191 | ALA | 5.262 | 4.556 | 0.707 | 0.707 |
| 161 | CYS | 198 | ILE | 0.074 | 0.772 | -0.697 | 0.697 |
| 74 | THR | 78 | LEU | 1.047 | 0.350 | 0.697 | 0.697 |
| 228 | ASP | 311 | TYR | 0.695 | 0.000 | 0.695 | 0.695 |
| 239 | MET | 311 | TYR | 1.297 | 1.989 | -0.692 | 0.692 |
| 82 | TYR | 331 | CYS | 0.691 | 0.000 | 0.691 | 0.691 |
| 298 | ILE | 332 | LEU | 0.689 | 0.000 | 0.689 | 0.689 |
| 217 | PHE | 224 | THR | 2.263 | 1.582 | 0.681 | 0.681 |
| 57 | THR | 59 | PHE | 1.263 | 0.584 | 0.679 | 0.679 |
| 314 | ILE | 320 | SER | 0.678 | 0.000 | 0.678 | 0.678 |
| 341 | PRO | 351 | PHE | 0.000 | 0.678 | -0.678 | 0.678 |
| 115 | ALA | 345 | TYR | 0.676 | 0.000 | 0.676 | 0.676 |
| 86 | PHE | 128 | PHE | 0.675 | 0.000 | 0.675 | 0.675 |
| 244 | LEU | 248 | ILE | 1.057 | 1.732 | -0.675 | 0.675 |
| 296 | TYR | 301 | THR | 0.669 | 0.008 | 0.661 | 0.661 |
| 234 | LEU | 239 | MET | 1.844 | 1.184 | 0.661 | 0.661 |
| 323 | TYR | 326 | TYR | 0.648 | 0.000 | 0.648 | 0.648 |
| 212 | VAL | 229 | VAL | 5.867 | 6.512 | -0.645 | 0.645 |
| 234 | LEU | 238 | ASP | 0.907 | 1.548 | -0.640 | 0.640 |
| 244 | LEU | 308 | VAL | 0.853 | 0.213 | 0.640 | 0.640 |
| 266 | ILE | 286 | ILE | 0.000 | 0.638 | -0.638 | 0.638 |
| 153 | GLY | 206 | THR | 1.691 | 2.327 | -0.636 | 0.636 |
| 85 | VAL | 338 | CYS | 3.816 | 3.180 | 0.636 | 0.636 |
| 108 | HIS | 111 | VAL | 0.886 | 0.252 | 0.634 | 0.634 |
| 145 | GLU | 149 | ASN | 1.250 | 0.617 | 0.634 | 0.634 |
| 110 | ALA | 169 | LEU | 1.451 | 2.084 | -0.633 | 0.633 |
| 163 | ILE | 254 | PRO | 0.365 | 0.998 | -0.633 | 0.633 |
| 40 | GLY | 60 | SER | 0.371 | 1.003 | -0.632 | 0.632 |
| 178 | VAL | 268 | MET | 2.521 | 1.889 | 0.632 | 0.632 |
| 116 | ASN | 195 | SER | 2.658 | 3.287 | -0.629 | 0.629 |
| 166 | MET | 300 | PHE | 0.629 | 0.000 | 0.629 | 0.629 |
| 173 | ARG | 289 | ILE | 0.000 | 0.626 | -0.626 | 0.626 |
| 124 | SER | 337 | SER | 0.440 | 1.061 | -0.621 | 0.621 |
| 162 | SER | 296 | TYR | 0.000 | 0.620 | -0.620 | 0.620 |
| 212 | VAL | 230 | LEU | 0.057 | 0.676 | -0.619 | 0.619 |
| 117 | LEU | 169 | LEU | 0.618 | 0.000 | 0.618 | 0.618 |
| 246 | LEU | 251 | PHE | 0.723 | 1.339 | -0.616 | 0.616 |
| 303 | SER | 330 | LEU | 1.009 | 1.622 | -0.612 | 0.612 |
| 295 | MET | 298 | ILE | 0.000 | 0.611 | -0.611 | 0.611 |
| 109 | PRO | 188 | ALA | 0.971 | 0.362 | 0.609 | 0.609 |
| 42 | VAL | 57 | THR | 0.627 | 0.020 | 0.607 | 0.607 |
| 160 | TYR | 251 | PHE | 0.000 | 0.603 | -0.603 | 0.603 |
| 86 | PHE | 90 | LEU | 1.706 | 1.105 | 0.602 | 0.602 |
| 73 | LEU | 328 | VAL | 0.743 | 0.142 | 0.601 | 0.601 |
| 163 | ILE | 293 | LEU | 0.000 | 0.600 | -0.600 | 0.600 |
| 8 | TRP | 298 | ILE | 0.600 | 0.000 | 0.600 | 0.600 |
| 141 | TRP | 143 | TYR | 2.621 | 2.022 | 0.598 | 0.598 |
| 275 | ASP | 278 | SER | 0.224 | 0.818 | -0.594 | 0.594 |
| 295 | MET | 343 | VAL | 0.593 | 0.000 | 0.593 | 0.593 |
| 149 | ASN | 209 | LEU | 0.097 | 0.685 | -0.588 | 0.588 |
| 231 | PRO | 234 | LEU | 1.112 | 0.525 | 0.587 | 0.587 |
| 59 | PHE | 216 | ILE | 0.586 | 0.000 | 0.586 | 0.586 |
| 387 | SER | 388 | SER | 1.687 | 1.101 | 0.585 | 0.585 |
| 214 | GLN | 226 | CYS | 1.135 | 1.720 | -0.585 | 0.585 |
| 73 | LEU | 77 | PHE | 1.201 | 1.777 | -0.576 | 0.576 |
| 134 | TYR | 141 | TRP | 5.471 | 4.896 | 0.575 | 0.575 |
| 305 | LEU | 309 | VAL | 0.107 | 0.681 | -0.574 | 0.574 |
| 272 | SER | 282 | ARG | 0.571 | 0.000 | 0.571 | 0.571 |
| 97 | LEU | 119 | LEU | 0.228 | 0.795 | -0.567 | 0.567 |
| 170 | SER | 261 | ALA | 0.559 | 1.125 | -0.566 | 0.566 |
| 128 | PHE | 330 | LEU | 0.000 | 0.563 | -0.563 | 0.563 |
| 173 | ARG | 292 | VAL | 0.556 | 0.000 | 0.556 | 0.556 |
| 302 | PRO | 329 | ALA | 1.902 | 1.347 | 0.555 | 0.555 |
| 166 | MET | 289 | ILE | 0.000 | 0.555 | -0.555 | 0.555 |
| 184 | SER | 186 | LYS | 1.638 | 2.193 | -0.554 | 0.554 |
| 93 | ASN | 337 | SER | 2.783 | 3.338 | -0.554 | 0.554 |
| 132 | ILE | 136 | ILE | 1.036 | 1.589 | -0.553 | 0.553 |
| 69 | LEU | 138 | GLY | 0.550 | 0.000 | 0.550 | 0.550 |
| 240 | PHE | 308 | VAL | 1.308 | 0.777 | 0.531 | 0.531 |
| 223 | ILE | 225 | THR | 0.055 | 0.583 | -0.527 | 0.527 |
| 126 | ILE | 127 | TRP | 0.000 | 0.527 | -0.527 | 0.527 |
| 69 | LEU | 221 | LEU | 0.526 | 0.000 | 0.526 | 0.526 |
| 120 | ALA | 158 | ASN | 3.515 | 2.996 | 0.519 | 0.519 |
| 64 | PHE | 67 | SER | 0.624 | 0.108 | 0.516 | 0.516 |
| 148 | CYS | 215 | THR | 1.072 | 1.584 | -0.512 | 0.512 |
| 82 | TYR | 83 | THR | 0.000 | 0.512 | -0.512 | 0.512 |
| 139 | ASN | 224 | THR | 0.884 | 1.392 | -0.508 | 0.508 |
| 110 | ALA | 173 | ARG | 0.000 | 0.508 | -0.508 | 0.508 |
| 66 | ALA | 320 | SER | 0.000 | 0.505 | -0.505 | 0.505 |
| 218 | ILE | 221 | LEU | 1.038 | 0.536 | 0.502 | 0.502 |
| 345 | TYR | 346 | PHE | 0.000 | 0.499 | -0.499 | 0.499 |
| 360 | LEU | 364 | VAL | 0.000 | 0.495 | -0.495 | 0.495 |
| 73 | LEU | 324 | ALA | 0.170 | 0.664 | -0.494 | 0.494 |
| 364 | VAL | 368 | LYS | 0.172 | 0.665 | -0.494 | 0.494 |
| 389 | SER | 390 | SER | 1.056 | 1.549 | -0.493 | 0.493 |
| 212 | VAL | 227 | HIS | 0.406 | 0.896 | -0.490 | 0.490 |
| 174 | TYR | 178 | VAL | 3.958 | 3.471 | 0.487 | 0.487 |
| 217 | PHE | 222 | ASN | 2.708 | 2.222 | 0.486 | 0.486 |
| 216 | ILE | 227 | HIS | 1.141 | 1.624 | -0.483 | 0.483 |
| 120 | ALA | 162 | SER | 1.750 | 1.273 | 0.477 | 0.477 |
| 148 | CYS | 226 | CYS | 6.581 | 6.104 | 0.477 | 0.477 |
| 170 | SER | 171 | VAL | 0.000 | 0.473 | -0.473 | 0.473 |
| 388 | SER | 389 | SER | 1.179 | 0.706 | 0.473 | 0.473 |
| 154 | PHE | 158 | ASN | 5.515 | 5.043 | 0.472 | 0.472 |
| 221 | LEU | 223 | ILE | 0.878 | 1.350 | -0.472 | 0.472 |
| 357 | ASN | 360 | LEU | 0.470 | 0.000 | 0.470 | 0.470 |
| 269 | LEU | 279 | GLU | 0.000 | 0.467 | -0.467 | 0.467 |
| 160 | TYR | 304 | ASN | 0.983 | 1.449 | -0.466 | 0.466 |
| 218 | ILE | 225 | THR | 1.545 | 2.010 | -0.465 | 0.465 |
| 245 | SER | 250 | VAL | 0.085 | 0.549 | -0.464 | 0.464 |
| 155 | PHE | 330 | LEU | 0.059 | 0.521 | -0.462 | 0.462 |
| 38 | LEU | 227 | HIS | 0.460 | 0.000 | 0.460 | 0.460 |
| 103 | ARG | 361 | CYS | 0.453 | 0.000 | 0.453 | 0.453 |
| 165 | PHE | 199 | TRP | 2.918 | 2.467 | 0.451 | 0.451 |
| 81 | VAL | 335 | LEU | 0.000 | 0.450 | -0.450 | 0.450 |
| 117 | LEU | 344 | TYR | 1.193 | 1.642 | -0.448 | 0.448 |
| 292 | VAL | 343 | VAL | 0.826 | 1.273 | -0.448 | 0.448 |
| 165 | PHE | 198 | ILE | 2.997 | 2.551 | 0.446 | 0.446 |
| 323 | TYR | 327 | ILE | 3.348 | 2.904 | 0.444 | 0.444 |
| 120 | ALA | 161 | CYS | 0.717 | 0.275 | 0.443 | 0.443 |
| 363 | SER | 364 | VAL | 0.226 | 0.668 | -0.443 | 0.443 |
| 230 | LEU | 231 | PRO | 0.410 | 0.851 | -0.441 | 0.441 |
| 153 | GLY | 210 | TYR | 7.645 | 8.082 | -0.437 | 0.437 |
| 93 | ASN | 125 | VAL | 0.042 | 0.477 | -0.435 | 0.435 |
| 170 | SER | 262 | TYR | 4.679 | 5.111 | -0.433 | 0.433 |
| 291 | THR | 343 | VAL | 0.171 | 0.603 | -0.431 | 0.431 |
| 177 | ILE | 268 | MET | 1.438 | 1.861 | -0.423 | 0.423 |
| 101 | LEU | 115 | ALA | 0.000 | 0.420 | -0.420 | 0.420 |
| 149 | ASN | 214 | GLN | 1.004 | 0.585 | 0.419 | 0.419 |
| 240 | PHE | 241 | ASN | 1.344 | 0.926 | 0.418 | 0.418 |
| 172 | GLN | 176 | VAL | 0.858 | 0.440 | 0.418 | 0.418 |
| 8 | TRP | 295 | MET | 0.000 | 0.416 | -0.416 | 0.416 |
| 152 | ILE | 228 | ASP | 0.414 | 0.000 | 0.414 | 0.414 |
| 205 | VAL | 242 | TYR | 2.810 | 3.223 | -0.413 | 0.413 |
| 135 | HIS | 326 | TYR | 0.000 | 0.412 | -0.412 | 0.412 |
| 309 | VAL | 313 | LEU | 0.878 | 1.289 | -0.411 | 0.411 |
| 96 | ALA | 100 | PHE | 0.000 | 0.411 | -0.411 | 0.411 |
| 74 | THR | 75 | THR | 0.408 | 0.000 | 0.408 | 0.408 |
| 214 | GLN | 227 | HIS | 5.318 | 5.721 | -0.404 | 0.404 |
| 77 | PHE | 81 | VAL | 2.046 | 2.441 | -0.394 | 0.394 |
| 309 | VAL | 322 | VAL | 0.392 | 0.000 | 0.392 | 0.392 |
| 125 | VAL | 337 | SER | 0.315 | 0.707 | -0.392 | 0.392 |
| 142 | ILE | 143 | TYR | 4.326 | 3.937 | 0.389 | 0.389 |
| 112 | ILE | 191 | ALA | 0.880 | 1.263 | -0.383 | 0.383 |
| 143 | TYR | 147 | LEU | 1.700 | 1.317 | 0.383 | 0.383 |
| 299 | CYS | 300 | PHE | 0.515 | 0.133 | 0.383 | 0.383 |
| 353 | ASP | 356 | LYS | 0.428 | 0.050 | 0.377 | 0.377 |
| 109 | PRO | 172 | GLN | 2.299 | 2.674 | -0.375 | 0.375 |
| 303 | SER | 333 | SER | 2.512 | 2.883 | -0.370 | 0.370 |
| 302 | PRO | 332 | LEU | 0.370 | 0.000 | 0.370 | 0.370 |
| 174 | TYR | 265 | MET | 5.259 | 4.891 | 0.368 | 0.368 |
| 166 | MET | 262 | TYR | 0.000 | 0.367 | -0.367 | 0.367 |
| 155 | PHE | 333 | SER | 0.000 | 0.364 | -0.364 | 0.364 |
| 37 | SER | 38 | LEU | 0.363 | 0.000 | 0.363 | 0.363 |
| 266 | ILE | 289 | ILE | 0.362 | 0.000 | 0.362 | 0.362 |
| 92 | SER | 342 | PHE | 0.360 | 0.000 | 0.360 | 0.360 |
| 253 | PHE | 257 | LEU | 3.167 | 3.527 | -0.360 | 0.360 |
| 75 | THR | 76 | VAL | 0.504 | 0.863 | -0.359 | 0.359 |
| 163 | ILE | 250 | VAL | 1.548 | 1.189 | 0.359 | 0.359 |
| 95 | MET | 351 | PHE | 0.847 | 0.492 | 0.355 | 0.355 |
| 106 | LYS | 111 | VAL | 0.000 | 0.351 | -0.351 | 0.351 |
| 61 | VAL | 65 | SER | 1.064 | 0.714 | 0.350 | 0.350 |
| 172 | GLN | 175 | TRP | 0.350 | 0.000 | 0.350 | 0.350 |
| 141 | TRP | 225 | THR | 0.504 | 0.158 | 0.346 | 0.346 |
| 259 | ALA | 293 | LEU | 0.470 | 0.815 | -0.345 | 0.345 |
| 128 | PHE | 131 | LYS | 0.342 | 0.000 | 0.342 | 0.342 |
| 141 | TRP | 215 | THR | 1.447 | 1.108 | 0.339 | 0.339 |
| 117 | LEU | 345 | TYR | 0.335 | 0.000 | 0.335 | 0.335 |
| 207 | ILE | 211 | VAL | 0.000 | 0.335 | -0.335 | 0.335 |
| 89 | GLY | 125 | VAL | 0.830 | 1.162 | -0.332 | 0.332 |
| 262 | TYR | 286 | ILE | 0.000 | 0.330 | -0.330 | 0.330 |
| 124 | SER | 159 | MET | 0.517 | 0.187 | 0.329 | 0.329 |
| 269 | LEU | 283 | LYS | 0.000 | 0.329 | -0.329 | 0.329 |
| 101 | LEU | 102 | PHE | 1.028 | 1.356 | -0.328 | 0.328 |
| 160 | TYR | 163 | ILE | 0.326 | 0.000 | 0.326 | 0.326 |
| 218 | ILE | 223 | ILE | 5.342 | 5.668 | -0.326 | 0.326 |
| 99 | VAL | 104 | THR | 1.994 | 2.319 | -0.325 | 0.325 |
| 96 | ALA | 341 | PRO | 0.000 | 0.324 | -0.324 | 0.324 |
| 98 | TRP | 358 | ALA | 1.518 | 1.194 | 0.324 | 0.324 |
| 157 | GLY | 206 | THR | 1.512 | 1.190 | 0.322 | 0.322 |
| 243 | PHE | 307 | LEU | 3.062 | 3.384 | -0.321 | 0.321 |
| 74 | THR | 79 | PRO | 1.644 | 1.323 | 0.321 | 0.321 |
| 310 | HIS | 314 | ILE | 3.277 | 2.958 | 0.319 | 0.319 |
| 135 | HIS | 330 | LEU | 0.000 | 0.319 | -0.319 | 0.319 |
| 47 | HIS | 48 | VAL | 0.000 | 0.318 | -0.318 | 0.318 |
| 75 | THR | 138 | GLY | 0.315 | 0.000 | 0.315 | 0.315 |
| 286 | ILE | 290 | VAL | 0.181 | 0.489 | -0.308 | 0.308 |
| 313 | LEU | 322 | VAL | 0.809 | 1.116 | -0.307 | 0.307 |
| 360 | LEU | 363 | SER | 0.426 | 0.727 | -0.301 | 0.301 |
| 248 | ILE | 253 | PHE | 2.978 | 3.278 | -0.300 | 0.300 |
| 217 | PHE | 219 | PRO | 1.606 | 1.903 | -0.298 | 0.298 |
| 351 | PHE | 355 | ALA | 0.106 | 0.402 | -0.296 | 0.296 |
| 108 | HIS | 109 | PRO | 3.402 | 3.697 | -0.295 | 0.295 |
| 59 | PHE | 217 | PHE | 0.295 | 0.000 | 0.295 | 0.295 |
| 69 | LEU | 75 | THR | 0.294 | 0.000 | 0.294 | 0.294 |
| 70 | THR | 221 | LEU | 0.289 | 0.000 | 0.289 | 0.289 |
| 272 | SER | 274 | MET | 2.161 | 1.873 | 0.288 | 0.288 |
| 295 | MET | 299 | CYS | 0.287 | 0.000 | 0.287 | 0.287 |
| 293 | LEU | 297 | LEU | 0.376 | 0.662 | -0.286 | 0.286 |
| 128 | PHE | 129 | PRO | 0.699 | 0.983 | -0.284 | 0.284 |
| 39 | ILE | 60 | SER | 0.281 | 0.000 | 0.281 | 0.281 |
| 89 | GLY | 338 | CYS | 2.070 | 1.789 | 0.280 | 0.280 |
| 67 | SER | 72 | LYS | 0.000 | 0.277 | -0.277 | 0.277 |
| 128 | PHE | 331 | CYS | 0.000 | 0.276 | -0.276 | 0.276 |
| 37 | SER | 320 | SER | 0.275 | 0.000 | 0.275 | 0.275 |
| 247 | ALA | 308 | VAL | 0.799 | 0.524 | 0.275 | 0.275 |
| 295 | MET | 344 | TYR | 0.272 | 0.000 | 0.272 | 0.272 |
| 347 | VAL | 352 | ARG | 0.000 | 0.272 | -0.272 | 0.272 |
| 243 | PHE | 308 | VAL | 0.573 | 0.304 | 0.269 | 0.269 |
| 360 | LEU | 365 | ARG | 0.000 | 0.263 | -0.263 | 0.263 |
| 167 | THR | 257 | LEU | 0.729 | 0.467 | 0.263 | 0.263 |
| 174 | TYR | 268 | MET | 1.476 | 1.214 | 0.262 | 0.262 |
| 227 | HIS | 228 | ASP | 0.261 | 0.000 | 0.261 | 0.261 |
| 209 | LEU | 242 | TYR | 3.761 | 3.500 | 0.261 | 0.261 |
| 141 | TRP | 151 | LEU | 1.470 | 1.726 | -0.256 | 0.256 |
| 173 | ARG | 262 | TYR | 0.256 | 0.000 | 0.256 | 0.256 |
| 98 | TRP | 99 | VAL | 0.998 | 0.743 | 0.255 | 0.255 |
| 163 | ILE | 251 | PHE | 0.027 | 0.280 | -0.253 | 0.253 |
| 332 | LEU | 335 | LEU | 0.253 | 0.000 | 0.253 | 0.253 |
| 202 | ILE | 250 | VAL | 0.257 | 0.509 | -0.252 | 0.252 |
| 39 | ILE | 318 | GLY | 0.251 | 0.000 | 0.251 | 0.251 |
| 160 | TYR | 296 | TYR | 0.000 | 0.251 | -0.251 | 0.251 |
| 131 | LYS | 135 | HIS | 0.006 | 0.253 | -0.247 | 0.247 |
| 69 | LEU | 218 | ILE | 0.247 | 0.000 | 0.247 | 0.247 |
| 127 | TRP | 147 | LEU | 1.164 | 1.410 | -0.245 | 0.245 |
| 84 | ILE | 89 | GLY | 0.099 | 0.344 | -0.245 | 0.245 |
| 348 | SER | 350 | ASP | 0.571 | 0.328 | 0.243 | 0.243 |
| 68 | VAL | 324 | ALA | 0.240 | 0.000 | 0.240 | 0.240 |
| 98 | TRP | 354 | HIS | 0.000 | 0.234 | -0.234 | 0.234 |
| 94 | GLY | 122 | LEU | 0.497 | 0.729 | -0.232 | 0.232 |
| 184 | SER | 187 | LYS | 0.232 | 0.000 | 0.232 | 0.232 |
| 140 | ASN | 142 | ILE | 0.625 | 0.854 | -0.228 | 0.228 |
| 263 | VAL | 267 | ARG | 0.607 | 0.833 | -0.226 | 0.226 |
| 203 | LEU | 210 | TYR | 0.000 | 0.224 | -0.224 | 0.224 |
| 79 | PRO | 136 | ILE | 1.082 | 0.858 | 0.224 | 0.224 |
| 343 | VAL | 347 | VAL | 0.000 | 0.223 | -0.223 | 0.223 |
| 117 | LEU | 162 | SER | 3.309 | 3.088 | 0.221 | 0.221 |
| 157 | GLY | 202 | ILE | 2.803 | 3.024 | -0.221 | 0.221 |
| 327 | ILE | 331 | CYS | 0.000 | 0.219 | -0.219 | 0.219 |
| 177 | ILE | 269 | LEU | 0.000 | 0.219 | -0.219 | 0.219 |
| 216 | ILE | 224 | THR | 2.890 | 2.672 | 0.219 | 0.219 |
| 160 | TYR | 307 | LEU | 0.237 | 0.019 | 0.218 | 0.218 |
| 209 | LEU | 246 | LEU | 0.000 | 0.217 | -0.217 | 0.217 |
| 133 | ALA | 143 | TYR | 1.550 | 1.766 | -0.215 | 0.215 |
| 269 | LEU | 289 | ILE | 0.215 | 0.000 | 0.215 | 0.215 |
| 99 | VAL | 355 | ALA | 0.000 | 0.215 | -0.215 | 0.215 |
| 120 | ALA | 199 | TRP | 1.745 | 1.535 | 0.210 | 0.210 |
| 177 | ILE | 282 | ARG | 0.000 | 0.209 | -0.209 | 0.209 |
| 386 | TYR | 387 | SER | 3.847 | 3.638 | 0.208 | 0.208 |
| 81 | VAL | 331 | CYS | 0.665 | 0.458 | 0.207 | 0.207 |
| 137 | HIS | 142 | ILE | 0.644 | 0.438 | 0.206 | 0.206 |
| 38 | LEU | 320 | SER | 0.203 | 0.000 | 0.203 | 0.203 |
| 100 | PHE | 111 | VAL | 3.179 | 2.977 | 0.202 | 0.202 |
| 367 | VAL | 371 | GLN | 0.201 | 0.000 | 0.201 | 0.201 |
| 169 | LEU | 262 | TYR | 0.000 | 0.201 | -0.201 | 0.201 |
| 328 | VAL | 332 | LEU | 0.000 | 0.200 | -0.200 | 0.200 |
| 116 | ASN | 199 | TRP | 2.840 | 2.641 | 0.199 | 0.199 |
| 113 | TYR | 195 | SER | 1.372 | 1.177 | 0.196 | 0.196 |
| 262 | TYR | 293 | LEU | 0.673 | 0.869 | -0.196 | 0.196 |
| 43 | ASP | 45 | THR | 0.193 | 0.000 | 0.193 | 0.193 |
| 312 | PHE | 316 | SER | 0.193 | 0.000 | 0.193 | 0.193 |
| 172 | GLN | 187 | LYS | 0.000 | 0.188 | -0.188 | 0.188 |
| 83 | THR | 87 | VAL | 0.279 | 0.466 | -0.187 | 0.187 |
| 77 | PHE | 78 | LEU | 0.000 | 0.186 | -0.186 | 0.186 |
| 177 | ILE | 286 | ILE | 0.000 | 0.186 | -0.186 | 0.186 |
| 331 | CYS | 334 | THR | 0.181 | 0.000 | 0.181 | 0.181 |
| 240 | PHE | 244 | LEU | 0.966 | 1.145 | -0.179 | 0.179 |
| 167 | THR | 296 | TYR | 0.179 | 0.000 | 0.179 | 0.179 |
| 100 | PHE | 118 | ALA | 0.000 | 0.176 | -0.176 | 0.176 |
| 204 | LEU | 207 | ILE | 0.343 | 0.518 | -0.175 | 0.175 |
| 202 | ILE | 206 | THR | 0.370 | 0.196 | 0.174 | 0.174 |
| 216 | ILE | 223 | ILE | 0.620 | 0.446 | 0.173 | 0.173 |
| 230 | LEU | 235 | LEU | 0.444 | 0.271 | 0.173 | 0.173 |
| 84 | ILE | 88 | VAL | 0.114 | 0.287 | -0.173 | 0.173 |
| 64 | PHE | 68 | VAL | 2.304 | 2.475 | -0.171 | 0.171 |
| 164 | LEU | 201 | LEU | 0.170 | 0.000 | 0.170 | 0.170 |
| 241 | ASN | 315 | LYS | 0.169 | 0.000 | 0.169 | 0.169 |
| 148 | CYS | 149 | ASN | 0.860 | 0.691 | 0.169 | 0.169 |
| 206 | THR | 209 | LEU | 0.493 | 0.326 | 0.167 | 0.167 |
| 175 | TRP | 182 | GLY | 0.000 | 0.166 | -0.166 | 0.166 |
| 108 | HIS | 172 | GLN | 0.123 | 0.289 | -0.166 | 0.166 |
| 86 | PHE | 91 | PRO | 0.475 | 0.641 | -0.166 | 0.166 |
| 280 | LYS | 284 | ARG | 0.000 | 0.165 | -0.165 | 0.165 |
| 85 | VAL | 90 | LEU | 0.312 | 0.477 | -0.165 | 0.165 |
| 295 | MET | 336 | ASN | 2.908 | 3.071 | -0.163 | 0.163 |
| 366 | THR | 370 | MET | 1.022 | 0.859 | 0.163 | 0.163 |
| 350 | ASP | 354 | HIS | 0.163 | 0.000 | 0.163 | 0.163 |
| 37 | SER | 39 | ILE | 0.160 | 0.000 | 0.160 | 0.160 |
| 169 | LEU | 173 | ARG | 0.000 | 0.159 | -0.159 | 0.159 |
| 123 | LEU | 199 | TRP | 0.544 | 0.701 | -0.158 | 0.158 |
| 62 | ASP | 63 | GLU | 0.186 | 0.029 | 0.157 | 0.157 |
| 312 | PHE | 313 | LEU | 0.157 | 0.000 | 0.157 | 0.157 |
| 166 | MET | 296 | TYR | 0.154 | 0.000 | 0.154 | 0.154 |
| 167 | THR | 170 | SER | 0.000 | 0.154 | -0.154 | 0.154 |
| 85 | VAL | 335 | LEU | 1.589 | 1.435 | 0.154 | 0.154 |
| 205 | VAL | 250 | VAL | 0.144 | 0.298 | -0.154 | 0.154 |
| 97 | LEU | 100 | PHE | 0.153 | 0.000 | 0.153 | 0.153 |
| 177 | ILE | 265 | MET | 1.393 | 1.543 | -0.150 | 0.150 |
| 107 | LYS | 112 | ILE | 0.000 | 0.149 | -0.149 | 0.149 |
| 247 | ALA | 304 | ASN | 0.080 | 0.228 | -0.147 | 0.147 |
| 61 | VAL | 66 | ALA | 0.478 | 0.331 | 0.147 | 0.147 |
| 275 | ASP | 276 | GLU | 0.000 | 0.147 | -0.147 | 0.147 |
| 168 | CYS | 194 | ILE | 0.393 | 0.538 | -0.145 | 0.145 |
| 343 | VAL | 348 | SER | 0.000 | 0.145 | -0.145 | 0.145 |
| 218 | ILE | 220 | ALA | 0.291 | 0.147 | 0.144 | 0.144 |
| 135 | HIS | 327 | ILE | 0.000 | 0.144 | -0.144 | 0.144 |
| 253 | PHE | 254 | PRO | 1.882 | 1.742 | 0.140 | 0.140 |
| 113 | TYR | 194 | ILE | 3.678 | 3.538 | 0.140 | 0.140 |
| 170 | SER | 257 | LEU | 0.000 | 0.139 | -0.139 | 0.139 |
| 192 | ILE | 196 | LEU | 0.352 | 0.213 | 0.139 | 0.139 |
| 97 | LEU | 122 | LEU | 0.416 | 0.279 | 0.138 | 0.138 |
| 148 | CYS | 214 | GLN | 1.580 | 1.444 | 0.137 | 0.137 |
| 287 | LYS | 291 | THR | 0.165 | 0.298 | -0.133 | 0.133 |
| 156 | TYR | 159 | MET | 1.017 | 1.149 | -0.132 | 0.132 |
| 311 | TYR | 314 | ILE | 0.252 | 0.121 | 0.131 | 0.131 |
| 137 | HIS | 140 | ASN | 0.261 | 0.391 | -0.130 | 0.130 |
| 131 | LYS | 156 | TYR | 0.000 | 0.128 | -0.128 | 0.128 |
| 248 | ILE | 252 | LEU | 0.285 | 0.157 | 0.128 | 0.128 |
| 250 | VAL | 296 | TYR | 0.128 | 0.000 | 0.128 | 0.128 |
| 100 | PHE | 112 | ILE | 0.127 | 0.000 | 0.127 | 0.127 |
| 78 | LEU | 327 | ILE | 1.773 | 1.900 | -0.127 | 0.127 |
| 127 | TRP | 130 | LEU | 1.012 | 0.887 | 0.124 | 0.124 |
| 163 | ILE | 166 | MET | 0.000 | 0.124 | -0.124 | 0.124 |
| 89 | GLY | 337 | SER | 0.122 | 0.000 | 0.122 | 0.122 |
| 119 | LEU | 123 | LEU | 0.874 | 0.754 | 0.121 | 0.121 |
| 110 | ALA | 114 | MET | 0.121 | 0.000 | 0.121 | 0.121 |
| 16 | LEU | 19 | SER | 0.398 | 0.519 | -0.121 | 0.121 |
| 109 | PRO | 113 | TYR | 0.043 | 0.162 | -0.119 | 0.119 |
| 86 | PHE | 87 | VAL | 0.119 | 0.000 | 0.119 | 0.119 |
| 201 | LEU | 205 | VAL | 0.536 | 0.418 | 0.118 | 0.118 |
| 237 | GLY | 311 | TYR | 0.000 | 0.116 | -0.116 | 0.116 |
| 89 | GLY | 122 | LEU | 0.000 | 0.116 | -0.116 | 0.116 |
| 123 | LEU | 126 | ILE | 0.115 | 0.000 | 0.115 | 0.115 |
| 72 | LYS | 76 | VAL | 0.114 | 0.000 | 0.114 | 0.114 |
| 93 | ASN | 121 | ASP | 3.489 | 3.375 | 0.114 | 0.114 |
| 133 | ALA | 137 | HIS | 0.157 | 0.271 | -0.114 | 0.114 |
| 341 | PRO | 345 | TYR | 0.112 | 0.000 | 0.112 | 0.112 |
| 164 | LEU | 202 | ILE | 1.348 | 1.236 | 0.111 | 0.111 |
| 214 | GLN | 225 | THR | 0.678 | 0.789 | -0.111 | 0.111 |
| 109 | PRO | 187 | LYS | 2.355 | 2.459 | -0.104 | 0.104 |
| 256 | PHE | 260 | SER | 0.104 | 0.000 | 0.104 | 0.104 |
| 294 | ALA | 298 | ILE | 0.103 | 0.000 | 0.103 | 0.103 |
| 239 | MET | 243 | PHE | 1.208 | 1.310 | -0.102 | 0.102 |
| 109 | PRO | 191 | ALA | 1.697 | 1.595 | 0.102 | 0.102 |
| 288 | LEU | 292 | VAL | 0.099 | 0.000 | 0.099 | 0.099 |
| 261 | ALA | 265 | MET | 0.285 | 0.187 | 0.098 | 0.098 |
| 170 | SER | 292 | VAL | 0.097 | 0.000 | 0.097 | 0.097 |
| 341 | PRO | 342 | PHE | 0.097 | 0.000 | 0.097 | 0.097 |
| 145 | GLU | 215 | THR | 4.631 | 4.727 | -0.096 | 0.096 |
| 156 | TYR | 206 | THR | 0.155 | 0.062 | 0.092 | 0.092 |
| 242 | TYR | 245 | SER | 0.092 | 0.000 | 0.092 | 0.092 |
| 336 | ASN | 339 | ILE | 0.000 | 0.091 | -0.091 | 0.091 |
| 3 | SER | 4 | PRO | 0.763 | 0.672 | 0.091 | 0.091 |
| 269 | LEU | 285 | ALA | 0.090 | 0.000 | 0.090 | 0.090 |
| 215 | THR | 224 | THR | 0.492 | 0.580 | -0.088 | 0.088 |
| 372 | VAL | 375 | THR | 0.094 | 0.006 | 0.088 | 0.088 |
| 322 | VAL | 325 | LEU | 0.087 | 0.000 | 0.087 | 0.087 |
| 102 | PHE | 103 | ARG | 0.086 | 0.000 | 0.086 | 0.086 |
| 90 | LEU | 91 | PRO | 1.121 | 1.036 | 0.085 | 0.085 |
| 68 | VAL | 72 | LYS | 0.000 | 0.085 | -0.085 | 0.085 |
| 93 | ASN | 341 | PRO | 4.466 | 4.381 | 0.085 | 0.085 |
| 235 | LEU | 238 | ASP | 0.841 | 0.926 | -0.085 | 0.085 |
| 67 | SER | 68 | VAL | 0.084 | 0.000 | 0.084 | 0.084 |
| 310 | HIS | 322 | VAL | 0.000 | 0.083 | -0.083 | 0.083 |
| 151 | LEU | 152 | ILE | 0.000 | 0.082 | -0.082 | 0.082 |
| 340 | ASP | 341 | PRO | 0.914 | 0.995 | -0.081 | 0.081 |
| 170 | SER | 344 | TYR | 0.081 | 0.000 | 0.081 | 0.081 |
| 156 | TYR | 303 | SER | 0.000 | 0.080 | -0.080 | 0.080 |
| 189 | ASN | 192 | ILE | 0.103 | 0.022 | 0.080 | 0.080 |
| 64 | PHE | 321 | HIS | 0.079 | 0.000 | 0.079 | 0.079 |
| 96 | ALA | 344 | TYR | 0.000 | 0.079 | -0.079 | 0.079 |
| 171 | VAL | 261 | ALA | 0.078 | 0.000 | 0.078 | 0.078 |
| 339 | ILE | 343 | VAL | 0.605 | 0.682 | -0.077 | 0.077 |
| 207 | ILE | 208 | PRO | 1.277 | 1.200 | 0.077 | 0.077 |
| 160 | TYR | 202 | ILE | 1.734 | 1.810 | -0.076 | 0.076 |
| 164 | LEU | 250 | VAL | 0.076 | 0.000 | 0.076 | 0.076 |
| 333 | SER | 334 | THR | 0.000 | 0.076 | -0.076 | 0.076 |
| 356 | LYS | 360 | LEU | 0.000 | 0.075 | -0.075 | 0.075 |
| 160 | TYR | 247 | ALA | 0.000 | 0.075 | -0.075 | 0.075 |
| 148 | CYS | 227 | HIS | 0.074 | 0.000 | 0.074 | 0.074 |
| 119 | LEU | 199 | TRP | 0.327 | 0.253 | 0.074 | 0.074 |
| 216 | ILE | 218 | ILE | 0.000 | 0.074 | -0.074 | 0.074 |
| 112 | ILE | 188 | ALA | 1.501 | 1.574 | -0.073 | 0.073 |
| 173 | ARG | 343 | VAL | 0.072 | 0.000 | 0.072 | 0.072 |
| 370 | MET | 374 | LEU | 0.071 | 0.000 | 0.071 | 0.071 |
| 92 | SER | 93 | ASN | 0.532 | 0.461 | 0.070 | 0.070 |
| 178 | VAL | 179 | ASN | 1.928 | 1.859 | 0.069 | 0.069 |
| 294 | ALA | 295 | MET | 0.000 | 0.068 | -0.068 | 0.068 |
| 156 | TYR | 160 | TYR | 2.135 | 2.067 | 0.068 | 0.068 |
| 247 | ALA | 252 | LEU | 4.326 | 4.259 | 0.068 | 0.068 |
| 163 | ILE | 258 | THR | 0.000 | 0.067 | -0.067 | 0.067 |
| 215 | THR | 225 | THR | 2.499 | 2.565 | -0.066 | 0.066 |
| 139 | ASN | 225 | THR | 2.100 | 2.034 | 0.066 | 0.066 |
| 19 | SER | 20 | LEU | 0.124 | 0.059 | 0.066 | 0.066 |
| 242 | TYR | 246 | LEU | 4.810 | 4.875 | -0.064 | 0.064 |
| 246 | LEU | 250 | VAL | 0.321 | 0.383 | -0.063 | 0.063 |
| 258 | THR | 262 | TYR | 0.496 | 0.435 | 0.061 | 0.061 |
| 173 | ARG | 285 | ALA | 0.000 | 0.061 | -0.061 | 0.061 |
| 95 | MET | 99 | VAL | 0.062 | 0.122 | -0.061 | 0.061 |
| 313 | LEU | 316 | SER | 0.000 | 0.060 | -0.060 | 0.060 |
| 163 | ILE | 167 | THR | 0.000 | 0.059 | -0.059 | 0.059 |
| 80 | ILE | 84 | ILE | 0.551 | 0.493 | 0.059 | 0.059 |
| 158 | ASN | 199 | TRP | 1.571 | 1.629 | -0.058 | 0.058 |
| 255 | ALA | 258 | THR | 0.012 | 0.070 | -0.058 | 0.058 |
| 301 | THR | 302 | PRO | 1.084 | 1.026 | 0.058 | 0.058 |
| 92 | SER | 338 | CYS | 0.283 | 0.340 | -0.057 | 0.057 |
| 255 | ALA | 293 | LEU | 0.000 | 0.056 | -0.056 | 0.056 |
| 38 | LEU | 323 | TYR | 0.055 | 0.000 | 0.055 | 0.055 |
| 209 | LEU | 243 | PHE | 1.182 | 1.237 | -0.054 | 0.054 |
| 316 | SER | 319 | GLN | 0.000 | 0.053 | -0.053 | 0.053 |
| 216 | ILE | 228 | ASP | 0.053 | 0.000 | 0.053 | 0.053 |
| 160 | TYR | 206 | THR | 0.000 | 0.052 | -0.052 | 0.052 |
| 238 | ASP | 241 | ASN | 0.077 | 0.026 | 0.052 | 0.052 |
| 83 | THR | 88 | VAL | 0.000 | 0.051 | -0.051 | 0.051 |
| 163 | ILE | 304 | ASN | 0.050 | 0.000 | 0.050 | 0.050 |
| 76 | VAL | 80 | ILE | 0.523 | 0.572 | -0.049 | 0.049 |
| 95 | MET | 358 | ALA | 0.000 | 0.048 | -0.048 | 0.048 |
| 198 | ILE | 202 | ILE | 0.071 | 0.119 | -0.048 | 0.048 |
| 213 | LYS | 229 | VAL | 0.048 | 0.000 | 0.048 | 0.048 |
| 124 | SER | 155 | PHE | 0.048 | 0.000 | 0.048 | 0.048 |
| 78 | LEU | 79 | PRO | 0.964 | 0.917 | 0.048 | 0.048 |
| 66 | ALA | 71 | GLY | 0.063 | 0.108 | -0.046 | 0.046 |
| 262 | TYR | 265 | MET | 2.417 | 2.462 | -0.045 | 0.045 |
| 84 | ILE | 338 | CYS | 0.044 | 0.000 | 0.044 | 0.044 |
| 190 | ILE | 194 | ILE | 0.831 | 0.788 | 0.043 | 0.043 |
| 231 | PRO | 233 | GLN | 0.042 | 0.000 | 0.042 | 0.042 |
| 69 | LEU | 225 | THR | 0.042 | 0.000 | 0.042 | 0.042 |
| 124 | SER | 334 | THR | 0.000 | 0.041 | -0.041 | 0.041 |
| 302 | PRO | 306 | LEU | 0.040 | 0.000 | 0.040 | 0.040 |
| 248 | ILE | 254 | PRO | 0.127 | 0.166 | -0.039 | 0.039 |
| 167 | THR | 171 | VAL | 0.052 | 0.091 | -0.039 | 0.039 |
| 194 | ILE | 198 | ILE | 0.666 | 0.705 | -0.039 | 0.039 |
| 215 | THR | 226 | CYS | 0.054 | 0.091 | -0.038 | 0.038 |
| 299 | CYS | 329 | ALA | 0.260 | 0.296 | -0.036 | 0.036 |
| 122 | LEU | 126 | ILE | 0.372 | 0.337 | 0.034 | 0.034 |
| 249 | GLY | 254 | PRO | 2.077 | 2.112 | -0.034 | 0.034 |
| 295 | MET | 300 | PHE | 0.034 | 0.000 | 0.034 | 0.034 |
| 99 | VAL | 103 | ARG | 0.150 | 0.117 | 0.033 | 0.033 |
| 144 | GLY | 215 | THR | 0.488 | 0.456 | 0.033 | 0.033 |
| 168 | CYS | 198 | ILE | 0.838 | 0.805 | 0.033 | 0.033 |
| 279 | GLU | 283 | LYS | 5.371 | 5.339 | 0.032 | 0.032 |
| 362 | ARG | 366 | THR | 0.031 | 0.000 | 0.031 | 0.031 |
| 129 | PRO | 130 | LEU | 0.000 | 0.028 | -0.028 | 0.028 |
| 62 | ASP | 65 | SER | 0.483 | 0.455 | 0.028 | 0.028 |
| 61 | VAL | 69 | LEU | 0.027 | 0.000 | 0.027 | 0.027 |
| 218 | ILE | 219 | PRO | 0.420 | 0.393 | 0.027 | 0.027 |
| 125 | VAL | 338 | CYS | 0.000 | 0.025 | -0.025 | 0.025 |
| 335 | LEU | 339 | ILE | 0.025 | 0.000 | 0.025 | 0.025 |
| 41 | LYS | 43 | ASP | 0.024 | 0.000 | 0.024 | 0.024 |
| 108 | HIS | 110 | ALA | 1.569 | 1.545 | 0.024 | 0.024 |
| 96 | ALA | 118 | ALA | 0.406 | 0.430 | -0.023 | 0.023 |
| 88 | VAL | 92 | SER | 0.000 | 0.022 | -0.022 | 0.022 |
| 306 | LEU | 329 | ALA | 0.805 | 0.825 | -0.020 | 0.020 |
| 251 | PHE | 252 | LEU | 1.529 | 1.549 | -0.020 | 0.020 |
| 265 | MET | 268 | MET | 0.020 | 0.000 | 0.020 | 0.020 |
| 268 | MET | 271 | SER | 0.006 | 0.026 | -0.019 | 0.019 |
| 370 | MET | 373 | SER | 0.039 | 0.058 | -0.019 | 0.019 |
| 299 | CYS | 339 | ILE | 0.207 | 0.189 | 0.018 | 0.018 |
| 114 | MET | 117 | LEU | 0.000 | 0.018 | -0.018 | 0.018 |
| 235 | LEU | 311 | TYR | 0.000 | 0.018 | -0.018 | 0.018 |
| 244 | LEU | 249 | GLY | 0.000 | 0.018 | -0.018 | 0.018 |
| 152 | ILE | 157 | GLY | 0.017 | 0.000 | 0.017 | 0.017 |
| 373 | SER | 376 | SER | 0.013 | 0.000 | 0.013 | 0.013 |
| 112 | ILE | 192 | ILE | 0.888 | 0.876 | 0.012 | 0.012 |
| 205 | VAL | 246 | LEU | 1.287 | 1.298 | -0.011 | 0.011 |
| 179 | ASN | 180 | PRO | 0.126 | 0.138 | -0.011 | 0.011 |
| 376 | SER | 377 | LYS | 0.019 | 0.008 | 0.011 | 0.011 |
| 291 | THR | 295 | MET | 0.000 | 0.010 | -0.010 | 0.010 |
| 81 | VAL | 85 | VAL | 0.241 | 0.231 | 0.010 | 0.010 |
| 188 | ALA | 189 | ASN | 0.000 | 0.008 | -0.008 | 0.008 |
| 300 | PHE | 304 | ASN | 0.465 | 0.457 | 0.008 | 0.008 |
| 89 | GLY | 94 | GLY | 0.100 | 0.093 | 0.008 | 0.008 |
| 164 | LEU | 198 | ILE | 1.446 | 1.454 | -0.007 | 0.007 |
| 68 | VAL | 73 | LEU | 0.000 | 0.007 | -0.007 | 0.007 |
| 68 | VAL | 139 | ASN | 0.007 | 0.000 | 0.007 | 0.007 |
| 5 | SER | 7 | ALA | 0.007 | 0.000 | 0.007 | 0.007 |
| 385 | SER | 386 | TYR | 0.000 | 0.005 | -0.005 | 0.005 |
| 112 | ILE | 195 | SER | 0.637 | 0.641 | -0.004 | 0.004 |
| 112 | ILE | 116 | ASN | 0.626 | 0.630 | -0.003 | 0.003 |
| 164 | LEU | 254 | PRO | 0.801 | 0.804 | -0.003 | 0.003 |
| 58 | VAL | 219 | PRO | 0.003 | 0.000 | 0.003 | 0.003 |
| 262 | TYR | 344 | TYR | 0.001 | 0.000 | 0.001 | 0.001 |
| 257 | LEU | 260 | SER | 0.000 | 0.000 | -0.000 | 0.000 |
RRCS change distribution
0.14
Mean ΔRRCS
1.87
Std Dev
0.03
Median
Magnitude classification
26
High (|Δ| ≥ 5.0)
51
Medium (2.6 ≤ |Δ| < 5.0)
699
Low (|Δ| < 2.6)
Methods
RRCS analysis. Residue-Residue Contact Scores (RRCS) quantify pairwise residue contact strength from inter-atomic distances; comparing active and inactive structures predicted by AlphaFold multistate (del Alamo et al., 2022) gives a per-pair ΔRRCS.
Receptor-specific ΔRRCS threshold. |ΔRRCS| ≥ 2.60, computed as max(mean(|Δ|) + σ, 0.2). The 0.2 floor ensures receptors with very small overall change still surface their largest contacts.
Variant data. Population frequencies from gnomAD v4; pathogenicity predictions from AlphaMissense; conservation from ProtVar / UniProt. The Het count column shows heterozygote allele counts; homozygote counts are uniformly zero across these rare missense variants in the current gnomAD v4 snapshot and are omitted.
Structural annotation. TM domain boundaries and generic numbering from GPCRdb.
What is RRCS?
Residue-Residue Contact Score (RRCS) measures how strongly two amino acids interact in a protein structure. When a protein changes shape (from inactive to active), these contact strengths change.
ΔRRCS (Delta RRCS) shows the difference in contact strength between states:
- Positive ΔRRCS. Contact is stronger in the active state.
- Negative ΔRRCS. Contact is stronger in the inactive state.
- Large |ΔRRCS|. Notable contact-score difference between the active and inactive models.
Residues with large ΔRRCS values mark positions whose contact environment differs between the active and inactive models. These positions may be useful candidates for structural interpretation or follow-up variant analysis, but they should not be interpreted as functional proof on their own.
Pathogenicity predictions
AlphaMissense scores estimate the likelihood that a missense substitution disrupts function, based on structural and evolutionary features. The published score thresholds bin each variant as:
- Pathogenic (score ≥ 0.564): consistent with disruptive substitutions in known disease genes.
- Ambiguous (0.34–0.563): score does not clearly favor either class.
- Benign (< 0.34): consistent with tolerated substitutions.
Conservation & population data
Conservation score. How well-preserved a position is across species (0 = variable, 1 = conserved). Highly conserved positions are often functionally important, but conservation alone is not proof of function.
Allele frequency. Population frequency of the variant in gnomAD v4. Rare variants are common across the genome and many are undersampled; rarity alone is not evidence of pathogenicity.
Sources: AlphaFold multistate · RRCS · gnomAD v4 · AlphaMissense · GPCRdb · UniProt / ProtVar